{"id":7128,"date":"2019-04-02T21:36:31","date_gmt":"2019-04-02T14:36:31","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=7128"},"modified":"2025-01-08T23:02:22","modified_gmt":"2025-01-08T16:02:22","slug":"fluticasone-propionat-flixonase","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/fluticasone-propionat-flixonase\/","title":{"rendered":"Fluticasone propionat &#8211; Flixonase"},"content":{"rendered":"<p><strong>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: <\/strong><\/p>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <a href=\"https:\/\/pharmog.com\/wp\/fluticason-propionat\/\">Fluticasone propionate<\/a><\/strong><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u1ed1c Corticosteroids d\u00f9ng \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p.<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): D07AC17, R01AD08, R03BA05.<\/p>\n<p><strong><em>Brand name:<\/em><\/strong> FLIXONASE<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: GlaxoSmithKline<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng: <\/strong><\/p>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>H\u1ed7n d\u1ecbch x\u1ecbt m\u0169i: 0.05% (kl\/kl) x h\u1ed9p 1 chai 60 li\u1ec1u x\u1ecbt.<\/p>\n<p>M\u1ed7i li\u1ec1u: Fluticasone propionate 50mcg.<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>FLIXONASE<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i li\u1ec1u x\u1ecbt m\u0169i c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Fluticasone propionate<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>50 mcg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"343\" height=\"622\" class=\"wp-image-7129\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/04\/word-image-189.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/04\/word-image-189.png 343w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/04\/word-image-189-165x300.png 165w\" sizes=\"auto, (max-width: 343px) 100vw, 343px\" \/><\/p>\n<p><strong>3. Video by Pharmog:<\/strong><\/p>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<p><strong>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng: <\/strong><\/p>\n<p><strong>4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>Thu\u1ed1c x\u1ecbt m\u0169i FLIXONASE \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong ph\u00f2ng v\u00e0 \u0111i\u1ec1u tr\u1ecb vi\u00eam m\u0169i d\u1ecb \u1ee9ng theo m\u00f9a k\u1ec3 c\u1ea3 vi\u00eam m\u0169i d\u1ecb \u1ee9ng do ph\u1ea5n hoa (s\u1ed1t c\u1ecf kh\u00f4) v\u00e0 vi\u00eam m\u0169i d\u1ecb \u1ee9ng quanh n\u0103m. \u1ede nh\u1eefng b\u1ec7nh nh\u00e2n vi\u00eam m\u0169i d\u1ecb \u1ee9ng, thu\u1ed1c x\u1ecbt m\u0169i FLIXONASE c\u0169ng \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 ki\u1ec3m so\u00e1t tri\u1ec7u ch\u1ee9ng \u0111au v\u00e0 n\u1eb7ng v\u00f9ng xoang \u0111i k\u00e8m. Fluticasone propionate c\u00f3 ho\u1ea1t t\u00ednh ch\u1ed1ng vi\u00eam m\u1ea1nh nh\u01b0ng khi s\u1eed d\u1ee5ng t\u1ea1i ch\u1ed7 tr\u00ean ni\u00eam m\u1ea1c m\u0169i th\u00ec kh\u00f4ng quan s\u00e1t th\u1ea5y t\u00e1c d\u1ee5ng to\u00e0n th\u00e2n.<\/p>\n<p><strong>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/strong><\/p>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p>B\u00ecnh x\u1ecbt c\u00f3 1 n\u1eafp ch\u1ed1ng b\u1ee5i \u0111\u1ec3 b\u1ea3o v\u1ec7 v\u00f2i x\u1ecbt v\u00e0 gi\u1eef cho v\u00f2i x\u1ecbt s\u1ea1ch. H\u00e3y nh\u1edb l\u1ea5y n\u1eafp ch\u1ed1ng b\u1ee5i n\u00e0y ra tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng b\u00ecnh x\u1ecbt. B\u00ecnh x\u1ecbt m\u1edbi (ho\u1eb7c b\u00ecnh x\u1ecbt \u0111\u00e3 kh\u00f4ng s\u1eed d\u1ee5ng trong v\u00e0i ng\u00e0y) c\u00f3 th\u1ec3 kh\u00f4ng ho\u1ea1t \u0111\u1ed9ng ngay l\u1ea7n \u0111\u1ea7u ti\u00ean, v\u00ec th\u1ebf, c\u1ea7n chu\u1ea9n b\u1ecb b\u00ecnh x\u1ecbt theo h\u01b0\u1edbng d\u1eabn trong m\u1ee5c &#8220;Chu\u1ea9n b\u1ecb b\u00ecnh x\u1ecbt&#8221;.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"572\" height=\"469\" class=\"wp-image-7130\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/04\/word-image-190.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/04\/word-image-190.png 572w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/04\/word-image-190-300x246.png 300w\" sizes=\"auto, (max-width: 572px) 100vw, 572px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"571\" height=\"541\" class=\"wp-image-7131\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/04\/word-image-191.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/04\/word-image-191.png 571w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/04\/word-image-191-300x284.png 300w\" sizes=\"auto, (max-width: 571px) 100vw, 571px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"569\" height=\"227\" class=\"wp-image-7132\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/04\/word-image-192.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/04\/word-image-192.png 569w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/04\/word-image-192-300x120.png 300w\" sizes=\"auto, (max-width: 569px) 100vw, 569px\" \/><\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p>C\u1ea7n s\u1eed d\u1ee5ng th\u01b0\u1eddng xuy\u00ean \u0111\u1ec3 c\u00f3 \u0111\u01b0\u1ee3c hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb m\u1ed9t c\u00e1ch \u0111\u1ea7y \u0111\u1ee7. B\u1ec7nh nh\u00e2n c\u1ea7n \u0111\u01b0\u1ee3c gi\u1ea3i th\u00edch r\u1eb1ng c\u00f3 th\u1ec3 hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c kh\u00f4ng xu\u1ea5t hi\u1ec7n ngay do t\u00e1c d\u1ee5ng m\u1ea1nh nh\u1ea5t ch\u1ec9 c\u00f3 th\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c sau t\u1eeb 3 \u0111\u1ebfn 4 ng\u00e0y \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>Thu\u1ed1c x\u1ecbt m\u0169i FLIXONASE ch\u1ec9 d\u00f9ng qua \u0111\u01b0\u1eddng m\u0169i.<\/p>\n<p>\u0110\u1ec3 ph\u00f2ng ng\u1eeba v\u00e0 \u0111i\u1ec1u tr\u1ecb vi\u00eam m\u0169i d\u1ecb \u1ee9ng theo m\u00f9a v\u00e0 vi\u00eam m\u0169i d\u1ecb \u1ee9ng quanh n\u0103m:<\/p>\n<p><em>Ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb tr\u00ean 12 tu\u1ed5i:<\/em> X\u1ecbt hai nh\u00e1t v\u00e0o m\u1ed7i b\u00ean m\u0169i, m\u1ed9t l\u1ea7n m\u1ed7i ng\u00e0y, t\u1ed1t nh\u1ea5t l\u00e0 v\u00e0o bu\u1ed5i s\u00e1ng. Trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p c\u1ea7n thi\u1ebft c\u00f3 th\u1ec3 x\u1ecbt hai nh\u00e1t v\u00e0o m\u1ed7i b\u00ean m\u0169i, hai l\u1ea7n m\u1ed7i ng\u00e0y n\u1ebfu c\u1ea7n. Li\u1ec1u t\u1ed1i \u0111a m\u1ed7i ng\u00e0y kh\u00f4ng n\u00ean v\u01b0\u1ee3t qu\u00e1 4 nh\u00e1t x\u1ecbt cho m\u1ed7i b\u00ean m\u0169i.<\/p>\n<p><em>Tr\u1ebb t\u1eeb 4 \u0111\u1ebfn 11 tu\u1ed5i:<\/em> X\u1ecbt m\u1ed9t nh\u00e1t v\u00e0o m\u1ed7i b\u00ean m\u0169i, m\u1ed9t l\u1ea7n m\u1ed7i ng\u00e0y, t\u1ed1t nh\u1ea5t l\u00e0 v\u00e0o bu\u1ed5i s\u00e1ng. Trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p c\u1ea7n thi\u1ebft c\u00f3 th\u1ec3 x\u1ecbt m\u1ed9t nh\u00e1t v\u00e0o m\u1ed7i b\u00ean m\u0169i, hai l\u1ea7n m\u1ed7i ng\u00e0y. Li\u1ec1u t\u1ed1i \u0111a m\u1ed7i ng\u00e0y kh\u00f4ng n\u00ean v\u01b0\u1ee3t qu\u00e1 2 nh\u00e1t x\u1ecbt cho m\u1ed7i b\u00ean m\u0169i.<\/p>\n<p><em>Ng\u01b0\u1eddi cao tu\u1ed5i:<\/em> D\u00f9ng li\u1ec1u b\u00ecnh th\u01b0\u1eddng nh\u01b0 ng\u01b0\u1eddi l\u1edbn.<\/p>\n<p><strong>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh d\u00f9ng thu\u1ed1c x\u1ecbt m\u0169i FLIXONASE \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n qu\u00e1 m\u1eabn v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p><strong>4.4 Th\u1eadn tr\u1ecdng:<\/strong><\/p>\n<p>Nhi\u1ec5m khu\u1ea9n t\u1ea1i ch\u1ed7: Nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng m\u0169i c\u1ea7n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb th\u00edch h\u1ee3p, nh\u01b0ng \u0111\u00f3 kh\u00f4ng ph\u1ea3i l\u00e0 ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh \u0111\u1eb7c hi\u1ec7u trong \u0111i\u1ec1u tr\u1ecb v\u1edbi fluticasone propionate d\u1ea1ng x\u1ecbt m\u0169i.<\/p>\n<p>C\u1ea7n th\u1eadn tr\u1ecdng cho nh\u1eefng tr\u01b0\u1eddng h\u1ee3p ng\u1eebng \u0111i\u1ec1u tr\u1ecb b\u1eb1ng steroid to\u00e0n th\u00e2n v\u00e0 chuy\u1ec3n sang d\u00f9ng fluticasone propionate d\u1ea1ng x\u1ecbt m\u0169i, \u0111\u1eb7c bi\u1ec7t n\u1ebfu c\u00f3 l\u00fd do \u0111\u1ec3 nghi ng\u1edd r\u1eb1ng ch\u1ee9c n\u0103ng th\u01b0\u1ee3ng th\u1eadn b\u1ecb suy gi\u1ea3m.<\/p>\n<p>\u0110\u00e3 c\u00f3 b\u00e1o c\u00e1o v\u1ec1 t\u00e1c d\u1ee5ng to\u00e0n th\u00e2n khi d\u00f9ng corticosteroid x\u1ecbt qua \u0111\u01b0\u1eddng m\u0169i, \u0111\u1eb7c bi\u1ec7t khi d\u00f9ng li\u1ec1u cao trong th\u1eddi gian d\u00e0i. C\u00e1c t\u00e1c d\u1ee5ng n\u00e0y \u00edt x\u1ea3y ra h\u01a1n nhi\u1ec1u so v\u1edbi khi d\u00f9ng corticosteroid \u0111\u01b0\u1eddng u\u1ed1ng v\u00e0 c\u00f3 th\u1ec3 kh\u00e1c nhau \u1edf c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng b\u1ec7nh nh\u00e2n v\u00e0 c\u00e1c ch\u1ebf ph\u1ea9m corticosteroid.<\/p>\n<p>\u0110\u00e3 quan s\u00e1t th\u1ea5y gi\u1ea3m t\u1ed1c \u0111\u1ed9 t\u0103ng tr\u01b0\u1edfng \u1edf tr\u1ebb em \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi corticosteroid x\u1ecbt m\u0169i. Do \u0111\u00f3, n\u00ean duy tr\u00ec li\u1ec1u th\u1ea5p nh\u1ea5t cho tr\u1ebb em m\u00e0 v\u1eabn ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c tri\u1ec7u ch\u1ee9ng \u0111\u1ea7y \u0111\u1ee7.<\/p>\n<p>Trong qu\u00e1 tr\u00ecnh s\u1eed d\u1ee5ng thu\u1ed1c tr\u00ean th\u1ecb tr\u01b0\u1eddng \u0111\u00e3 c\u00f3 b\u00e1o c\u00e1o v\u1ec1 t\u01b0\u01a1ng t\u00e1c thu\u1ed1c c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n d\u00f9ng fluticasone propionate v\u00e0 ritonavir d\u1eabn \u0111\u1ebfn t\u00e1c d\u1ee5ng to\u00e0n th\u00e2n c\u1ee7a corticosteroid bao g\u1ed3m h\u1ed9i ch\u1ee9ng Cushing v\u00e0 suy th\u01b0\u1ee3ng th\u1eadn. Do \u0111\u00f3 n\u00ean tr\u00e1nh d\u00f9ng \u0111\u1ed3ng th\u1eddi fluticasone propionate v\u00e0 ritonavir tr\u1eeb khi l\u1ee3i \u00edch \u0111i\u1ec1u tr\u1ecb v\u01b0\u1ee3t tr\u1ed9i so v\u1edbi nguy c\u01a1 t\u00e1c d\u1ee5ng ph\u1ee5 to\u00e0n th\u00e2n c\u1ee7a corticosteroid (xem m\u1ee5c T\u01b0\u01a1ng t\u00e1c).<\/p>\n<p>Hi\u1ec7u qu\u1ea3 t\u1ed1i \u0111a c\u1ee7a thu\u1ed1c x\u1ecbt m\u0169i FLIXONASE c\u00f3 th\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c sau khi \u0111i\u1ec1u tr\u1ecb nhi\u1ec1u ng\u00e0y.<\/p>\n<p>M\u1eb7c d\u00f9 thu\u1ed1c x\u1ecbt m\u0169i FLIXONASE c\u00f3 th\u1ec3 ki\u1ec3m so\u00e1t h\u1ea7u h\u1ebft c\u00e1c tr\u01b0\u1eddng h\u1ee3p vi\u00eam m\u0169i d\u1ecb \u1ee9ng theo m\u00f9a, vi\u1ec7c ti\u1ebfp x\u00fac v\u1edbi d\u1ecb nguy\u00ean m\u00f9a h\u00e8 v\u1edbi s\u1ed1 l\u01b0\u1ee3ng l\u1edbn, b\u1ea5t th\u01b0\u1eddng c\u00f3 khi c\u1ea7n \u0111\u1ebfn nh\u1eefng \u0111i\u1ec1u tr\u1ecb b\u1ed5 sung th\u00edch h\u1ee3p.<\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>Fluticasone propionate h\u1ea7u nh\u01b0 kh\u00f4ng g\u00e2y \u1ea3nh hu\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/strong><\/p>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: B3<\/p>\n<p>US FDA pregnancy category: NA<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>C\u0169ng gi\u1ed1ng nh\u01b0 c\u00e1c thu\u1ed1c kh\u00e1c, ch\u1ec9 n\u00ean s\u1eed d\u1ee5ng fluticasone propionate x\u1ecbt m\u0169i trong thai k\u1ef3 v\u00e0 trong th\u1eddi gian cho con b\u00fa khi l\u1ee3i \u00edch mong \u0111\u1ee3i cho ng\u01b0\u1eddi m\u1eb9 v\u01b0\u1ee3t tr\u1ed9i so v\u1edbi c\u00e1c nguy c\u01a1 c\u00f3 th\u1ec3 g\u1eb7p ph\u1ea3i li\u00ean quan \u0111\u1ebfn thu\u1ed1c ho\u1eb7c b\u1ea5t c\u1ee9 \u0111i\u1ec1u tr\u1ecb thay th\u1ebf n\u00e0o.<\/p>\n<p>Ch\u01b0a c\u00f3 \u0111\u1ee7 b\u1eb1ng ch\u1ee9ng v\u1ec1 t\u00ednh an to\u00e0n khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef mang thai. Trong c\u00e1c nghi\u00ean c\u1ee9u tr\u00ean sinh s\u1ea3n \u1edf \u0111\u1ed9ng v\u1eadt, t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n \u0111i\u1ec3n h\u00ecnh c\u1ee7a c\u00e1c corticosteroid m\u1ea1nh ch\u1ec9 quan s\u00e1t th\u1ea5y trong tr\u01b0\u1eddng h\u1ee3p s\u1eed d\u1ee5ng \u0111\u01b0\u1eddng to\u00e0n th\u00e2n v\u1edbi li\u1ec1u cao; c\u00f2n khi d\u00f9ng tr\u1ef1c ti\u1ebfp qua \u0111\u01b0\u1eddng m\u0169i s\u1ebd \u0111\u1ea3m b\u1ea3o s\u1ef1 ph\u01a1i nhi\u1ec5m to\u00e0n th\u00e2n l\u00e0 t\u1ed1i thi\u1ec3u.<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>Vi\u1ec7c b\u00e0i ti\u1ebft fluticasone propionate v\u00e0o s\u1eefa ng\u01b0\u1eddi m\u1eb9 ch\u01b0a \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u. Sau khi ti\u00eam d\u01b0\u1edbi da cho chu\u1ed9t th\u00ed nghi\u1ec7m \u0111ang cho con b\u00fa, khi \u0111\u1ea1t \u0111\u1ebfn n\u1ed3ng \u0111\u1ed9 \u0111o \u0111\u01b0\u1ee3c trong huy\u1ebft t\u01b0\u01a1ng, \u0111\u00e3 c\u00f3 b\u1eb1ng ch\u1ee9ng cho th\u1ea5y fluticasone propionate hi\u1ec7n di\u1ec7n trong s\u1eefa m\u1eb9. Tuy nhi\u00ean n\u1ed3ng \u0111\u1ed9 huy\u1ebft t\u01b0\u01a1ng l\u00e0 th\u1ea5p \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng fluticasone propionate x\u1ecbt m\u0169i v\u1edbi li\u1ec1u khuy\u1ebfn c\u00e1o.<\/p>\n<p><strong>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/strong><\/p>\n<p>C\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n \u0111\u01b0\u1ee3c li\u1ec7t k\u00ea d\u01b0\u1edbi \u0111\u00e2y theo h\u1ec7 th\u1ed1ng c\u01a1 quan trong c\u01a1 th\u1ec3 v\u00e0 theo t\u1ea7n su\u1ea5t. T\u1ea7n su\u1ea5t \u0111\u01b0\u1ee3c \u0111\u1ecbnh ngh\u0129a nh\u01b0 sau: r\u1ea5t ph\u1ed5 bi\u1ebfn (\u2265 1\/10), ph\u1ed5 bi\u1ebfn (\u2265 1\/100 v\u00e0 &lt; 1\/10), kh\u00f4ng ph\u1ed5 bi\u1ebfn (\u2265 1\/1000 v\u00e0 &lt; 1\/100), hi\u1ebfm (\u2265 1\/10000 v\u00e0 &lt; 1\/1000) v\u00e0 r\u1ea5t hi\u1ebfm (&lt; 1\/10000) bao g\u1ed3m c\u00e1c b\u00e1o c\u00e1o ri\u00eang bi\u1ec7t. C\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n r\u1ea5t ph\u1ed5 bi\u1ebfn, ph\u1ed5 bi\u1ebfn v\u00e0 kh\u00f4ng ph\u1ed5 bi\u1ebfn nh\u00ecn chung \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh t\u1eeb c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng. C\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n hi\u1ebfm v\u00e0 r\u1ea5t hi\u1ebfm th\u01b0\u1eddng \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbng t\u1eeb c\u00e1c b\u00e1o c\u00e1o t\u1ef1 ph\u00e1t. Trong khi ph\u00e2n lo\u1ea1i t\u1ea7n su\u1ea5t t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n, c\u00e1c t\u1ef7 l\u1ec7 \u0111\u1ed1i ch\u1ee9ng t\u1eeb nh\u1eefng nh\u00f3m s\u1eed d\u1ee5ng gi\u1ea3 d\u01b0\u1ee3c kh\u00f4ng \u0111\u01b0\u1ee3c t\u00ednh \u0111\u1ebfn v\u00ec c\u00e1c t\u1ef7 l\u1ec7 n\u00e0y th\u01b0\u1eddng t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi c\u00e1c t\u1ef7 l\u1ec7 c\u1ee7a nh\u1eefng nh\u00f3m \u0111ang s\u1eed d\u1ee5ng thu\u1ed1c \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>R\u1ed1i lo\u1ea1n h\u1ec7 mi\u1ec5n d\u1ecbch: R\u1ea5t hi\u1ebfm: Ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn, ph\u1ea3n \u1ee9ng ph\u1ea3n v\u1ec7, co th\u1eaft ph\u1ebf qu\u1ea3n, ban tr\u00ean da, ph\u00f9 m\u1eb7t ho\u1eb7c l\u01b0\u1ee1i.<\/p>\n<p>R\u1ed1i lo\u1ea1n h\u1ec7 th\u1ea7n kinh: Ph\u1ed5 bi\u1ebfn: \u0110au \u0111\u1ea7u, m\u00f9i v\u00e0 v\u1ecb g\u00e2y kh\u00f3 ch\u1ecbu.<\/p>\n<p>C\u0169ng nh\u01b0 c\u00e1c thu\u1ed1c x\u1ecbt m\u0169i kh\u00e1c, \u0111\u00e3 c\u00f3 b\u00e1o c\u00e1o v\u1ec1 m\u00f9i v\u00e0 v\u1ecb g\u00e2y kh\u00f3 ch\u1ecbu v\u00e0 \u0111au \u0111\u1ea7u.<\/p>\n<p>R\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c: R\u1ea5t hi\u1ebfm: T\u0103ng nh\u00e3n \u00e1p, t\u0103ng \u00e1p l\u1ef1c n\u1ed9i nh\u00e3n, \u0111\u1ee5c th\u1ee7y tinh th\u1ec3.<\/p>\n<p>R\u1ea5t \u00edt c\u00f3 b\u00e1o c\u00e1o t\u1ef1 ph\u00e1t \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh sau khi \u0111i\u1ec1u tr\u1ecb l\u00e2u d\u00e0i. Tuy nhi\u00ean c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng k\u00e9o d\u00e0i m\u1ed9t n\u0103m \u0111\u00e3 cho th\u1ea5y fluticasone propionate x\u1ecbt m\u0169i kh\u00f4ng li\u00ean quan \u0111\u1ebfn vi\u1ec7c t\u0103ng t\u1ef7 l\u1ec7 m\u1eafc c\u00e1c bi\u1ebfn c\u1ed1 v\u1ec1 m\u1eaft bao g\u1ed3m \u0111\u1ee5c th\u1ee7y tinh th\u1ec3, t\u0103ng \u00e1p l\u1ef1c n\u1ed9i nh\u00e3n ho\u1eb7c t\u0103ng nh\u00e3n \u00e1p.<\/p>\n<p>R\u1ed1i lo\u1ea1n h\u00f4 h\u1ea5p, l\u1ed3ng ng\u1ef1c v\u00e0 trung th\u1ea5t:<\/p>\n<p>R\u1ea5t ph\u1ed5 bi\u1ebfn: Ch\u1ea3y m\u00e1u cam.<\/p>\n<p>Ph\u1ed5 bi\u1ebfn: Kh\u00f4 m\u0169i, k\u00edch th\u00edch m\u0169i, kh\u00f4 h\u1ecdng v\u00e0 k\u00edch th\u00edch h\u1ecdng.<\/p>\n<p>C\u0169ng gi\u1ed1ng nh\u01b0 c\u00e1c thu\u1ed1c d\u00f9ng trong m\u0169i kh\u00e1c, kh\u00f4 v\u00e0 k\u00edch th\u00edch m\u0169i v\u00e0 h\u1ecdng v\u00e0 ch\u1ea3y m\u00e1u cam \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o.<\/p>\n<p>R\u1ea5t hi\u1ebfm: Th\u1ee7ng v\u00e1ch ng\u0103n m\u0169i.<\/p>\n<p>\u0110\u00e3 c\u00f3 b\u00e1o c\u00e1o v\u1ec1 hi\u1ec7n t\u01b0\u1ee3ng th\u1ee7ng v\u00e1ch ng\u0103n m\u0169i sau khi s\u1eed d\u1ee5ng corticosteroid d\u1ea1ng x\u1ecbt m\u0169i.<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<p><strong>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/strong><\/p>\n<p>Ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c. V\u1edbi c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i nh\u1eb9, th\u01b0\u1eddng ch\u1ec9 c\u1ea7n ng\u1eebng thu\u1ed1c. Tr\u01b0\u1eddng h\u1ee3p m\u1eabn c\u1ea3m n\u1eb7ng ho\u1eb7c ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, c\u1ea7n ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 (gi\u1eef tho\u00e1ng kh\u00ed v\u00e0 d\u00f9ng epinephrin, th\u1edf oxygen, d\u00f9ng kh\u00e1ng histamin, corticoid&#8230;).<\/p>\n<p><strong>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/strong><\/p>\n<p>\u1ede nh\u1eefng \u0111i\u1ec1u ki\u1ec7n b\u00ecnh th\u01b0\u1eddng, n\u1ed3ng \u0111\u1ed9 fluticasone propionate trong huy\u1ebft t\u01b0\u01a1ng r\u1ea5t th\u1ea5p sau khi d\u00f9ng thu\u1ed1c qua \u0111\u01b0\u1eddng m\u0169i, do chuy\u1ec3n h\u00f3a l\u1ea7n \u0111\u1ea7u qu\u00e1 m\u1ee9c v\u00e0 \u0111\u1ed9 thanh th\u1ea3i to\u00e0n th\u00e2n qua cytochrome P450 3A4 \u1edf ru\u1ed9t v\u00e0 gan l\u1edbn. T\u01b0\u01a1ng t\u00e1c thu\u1ed1c do v\u1eady kh\u00f3 x\u1ea3y ra c\u00f3 \u00fd ngh\u0129a tr\u00ean l\u00e2m s\u00e0ng gi\u1eefa fluticasone propionate v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c.<\/p>\n<p>M\u1ed9t nghi\u00ean c\u1ee9u v\u1ec1 t\u01b0\u01a1ng t\u00e1c thu\u1ed1c \u1edf nh\u1eefng \u0111\u1ed1i t\u01b0\u1ee3ng kh\u1ecfe m\u1ea1nh cho th\u1ea5y ritonavir (m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf cytochrome P450 3A4 r\u1ea5t m\u1ea1nh) c\u00f3 th\u1ec3 l\u00e0m t\u0103ng cao n\u1ed3ng \u0111\u1ed9 fluticasone propionate trong huy\u1ebft t\u01b0\u01a1ng, d\u1eabn \u0111\u1ebfn gi\u1ea3m r\u00f5 r\u1ec7t n\u1ed3ng \u0111\u1ed9 cortisol trong huy\u1ebft thanh. Trong qu\u00e1 tr\u00ecnh s\u1eed d\u1ee5ng thu\u1ed1c tr\u00ean th\u1ecb tr\u01b0\u1eddng, \u0111\u00e3 c\u00f3 b\u00e1o c\u00e1o v\u1ec1 t\u01b0\u01a1ng t\u00e1c thu\u1ed1c c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n d\u00f9ng k\u1ebft h\u1ee3p fluticasone propionate d\u1ea1ng x\u1ecbt m\u0169i ho\u1eb7c d\u1ea1ng h\u00edt v\u1edbi ritonavir d\u1eabn \u0111\u1ebfn c\u00e1c t\u00e1c d\u1ee5ng to\u00e0n th\u00e2n c\u1ee7a corticosteroid bao g\u1ed3m h\u1ed9i ch\u1ee9ng Cushing v\u00e0 suy th\u01b0\u1ee3ng th\u1eadn. B\u1edfi v\u1eady, n\u00ean tr\u00e1nh s\u1eed d\u1ee5ng fluticasone propionate v\u00e0 ritonavir \u0111\u1ed3ng th\u1eddi tr\u1eeb phi l\u1ee3i \u00edch \u0111i\u1ec1u tr\u1ecb v\u01b0\u1ee3t tr\u1ed9i so v\u1edbi nguy c\u01a1 t\u00e1c d\u1ee5ng ph\u1ee5 to\u00e0n th\u00e2n c\u1ee7a corticosteroid.<\/p>\n<p>C\u00e1c nghi\u00ean c\u1ee9u ch\u1ec9 ra r\u1eb1ng c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf cytochrome P450 3A4 kh\u00e1c l\u00e0m t\u0103ng s\u1ef1 ph\u01a1i nhi\u1ec5m to\u00e0n th\u00e2n v\u1edbi fluticasone kh\u00f4ng \u0111\u00e1ng k\u1ec3 (nh\u01b0 erythromycin) v\u00e0 nh\u1eb9 (nh\u01b0 ketoconazole) m\u00e0 kh\u00f4ng l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 n\u1ed3ng \u0111\u1ed9 cortisol trong huy\u1ebft thanh. Tuy nhi\u00ean, c\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng ph\u1ed1i h\u1ee3p c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf m\u1ea1nh cytochrome P450 3A4 (v\u00ed d\u1ee5 ketoconazole) v\u00ec c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m t\u0103ng s\u1ef1 ph\u01a1i nhi\u1ec5m to\u00e0n th\u00e2n v\u1edbi fluticasone propionate.<\/p>\n<p><strong>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/strong><\/p>\n<p>Kh\u00f4ng c\u00f3 s\u1eb5n d\u1eef li\u1ec7u v\u1ec1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a hi\u1ec7n t\u01b0\u1ee3ng qu\u00e1 li\u1ec1u c\u1ea5p t\u00ednh ho\u1eb7c m\u1ea1n t\u00ednh khi d\u00f9ng fluticasone propionate d\u1ea1ng x\u1ecbt m\u0169i tr\u00ean b\u1ec7nh nh\u00e2n. Tr\u00ean ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n kh\u1ecfe m\u1ea1nh, ch\u01b0a th\u1ea5y c\u00f3 \u1ea3nh h\u01b0\u1edfng tr\u00ean ch\u1ee9c n\u0103ng tr\u1ee5c d\u01b0\u1edbi \u0111\u1ed3i-tuy\u1ebfn y\u00ean-th\u01b0\u1ee3ng th\u1eadn khi d\u00f9ng 2 mg fluticasone propionate d\u1ea1ng x\u1ecbt m\u0169i, 2 l\u1ea7n m\u1ed7i ng\u00e0y trong 7 ng\u00e0y.<\/p>\n<p>D\u00f9ng nh\u1eefng li\u1ec1u cao h\u01a1n li\u1ec1u \u0111\u1ec1 ngh\u1ecb trong m\u1ed9t kho\u1ea3ng th\u1eddi gian d\u00e0i c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn \u1ee9c ch\u1ebf t\u1ea1m th\u1eddi ch\u1ee9c n\u0103ng th\u01b0\u1ee3ng th\u1eadn.<\/p>\n<p>V\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y, n\u00ean ti\u1ebfp t\u1ee5c d\u00f9ng fluticasone propionate \u1edf li\u1ec1u \u0111i\u1ec1u tr\u1ecb c\u00f3 hi\u1ec7u qu\u1ea3 \u0111\u1ec3 ki\u1ec3m so\u00e1t tri\u1ec7u ch\u1ee9ng; ch\u1ee9c n\u0103ng th\u01b0\u1ee3ng th\u1eadn s\u1ebd h\u1ed3i ph\u1ee5c trong v\u00e0i ng\u00e0y v\u00e0 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c theo d\u00f5i b\u1eb1ng c\u00e1ch \u0111\u1ecbnh l\u01b0\u1ee3ng cortisol huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/strong><\/p>\n<p><strong>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/strong><\/p>\n<p>Fluticasone propionate c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng vi\u00eam m\u1ea1nh nh\u01b0ng khi s\u1eed d\u1ee5ng t\u1ea1i ch\u1ed7 tr\u00ean ni\u00eam m\u1ea1c m\u0169i kh\u00f4ng th\u1ea5y c\u00f3 t\u00e1c d\u1ee5ng to\u00e0n th\u00e2n.<\/p>\n<p>Fluticasone propionate \u00edt ho\u1eb7c kh\u00f4ng \u1ee9c ch\u1ebf tr\u1ee5c d\u01b0\u1edbi \u0111\u1ed3i-tuy\u1ebfn y\u00ean-th\u01b0\u1ee3ng th\u1eadn khi d\u00f9ng theo \u0111\u01b0\u1eddng x\u1ecbt m\u0169i.<\/p>\n<p>Sau khi x\u1ecbt m\u0169i fluticasone propionate (200 microgam\/ng\u00e0y), kh\u00f4ng th\u1ea5y c\u00f3 thay \u0111\u1ed5i \u0111\u00e1ng k\u1ec3 AUC cortisol huy\u1ebft thanh 24 gi\u1edd so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c (t\u1ec9 l\u1ec7 1.01; 90% kho\u1ea3ng tin c\u1eady (CI) 0.9-1.14).<\/p>\n<p>Fluticasone propionate l\u00e0 m\u1ed9t corticosteroid t\u1ed5ng h\u1ee3p c\u00f3 nguy\u00ean t\u1eed fluor g\u1eafn v\u00e0o khung steroid. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a c\u00e1c corticosteroid d\u00f9ng t\u1ea1i ch\u1ed7 l\u00e0 s\u1ef1 ph\u1ed1i h\u1ee3p 3 t\u00ednh ch\u1ea5t quan tr\u1ecdng ch\u1ed1ng vi\u00eam, ch\u1ed1ng ng\u1ee9a v\u00e0 t\u00e1c d\u1ee5ng co m\u1ea1ch. T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c m\u1ed9t ph\u1ea7n do li\u00ean k\u1ebft v\u1edbi th\u1ee5 th\u1ec3 steroid. C\u00e1c corticosteroid gi\u1ea3m vi\u00eam b\u1eb1ng c\u00e1ch l\u00e0m \u1ed5n \u0111\u1ecbnh m\u00e0ng lysosom c\u1ee7a b\u1ea1ch c\u1ea7u, \u1ee9c ch\u1ebf t\u1eadp trung \u0111\u1ea1i th\u1ef1c b\u00e0o trong c\u00e1c v\u00f9ng b\u1ecb vi\u00eam, gi\u1ea3m s\u1ef1 b\u00e1m d\u00ednh c\u1ee7a b\u1ea1ch c\u1ea7u v\u1edbi n\u1ed9i m\u00f4 mao m\u1ea1ch, gi\u1ea3m t\u00ednh th\u1ea5m th\u00e0nh mao m\u1ea1ch, gi\u1ea3m c\u00e1c th\u00e0nh ph\u1ea7n b\u1ed5 th\u1ec3, \u0111\u1ed1i kh\u00e1ng t\u00e1c d\u1ee5ng c\u1ee7a histamin v\u00e0 gi\u1ea3i ph\u00f3ng kinin t\u1eeb c\u00e1c c\u01a1 ch\u1ea5t, gi\u1ea3m t\u0103ng sinh c\u00e1c nguy\u00ean b\u00e0o s\u1ee3i, gi\u1ea3m l\u1eafng \u0111\u1ecdng collagen v\u00e0 sau \u0111\u00f3 gi\u1ea3m t\u1ea1o th\u00e0nh s\u1eb9o \u1edf m\u00f4.<\/p>\n<p>C\u00e1c corticosteroid, \u0111\u1eb7c bi\u1ec7t l\u00e0 c\u00e1c corticosteroid c\u00f3 fluor c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng ph\u00e2n b\u00e0o \u1edf nguy\u00ean b\u00e0o s\u1ee3i da v\u00e0 bi\u1ec3u b\u00ec.<\/p>\n<p>Fluticasone propionate l\u00e0 corticosteroid d\u00f9ng t\u1ea1i ch\u1ed7 c\u00f3 \u0111\u1ed9 thanh th\u1ea3i qua gan b\u01b0\u1edbc \u0111\u1ea7u r\u1ea5t l\u1edbn, d\u1eabn \u0111\u1ebfn sinh kh\u1ea3 d\u1ee5ng to\u00e0n th\u00e2n r\u1ea5t th\u1ea5p. \u0110i\u1ec1u \u0111\u00f3 l\u00e0m gi\u1ea3m nguy c\u01a1 t\u00e1c d\u1ee5ng ph\u1ee5 to\u00e0n th\u00e2n sau khi d\u00f9ng thu\u1ed1c theo \u0111\u01b0\u1eddng h\u00edt, ngay c\u1ea3 khi h\u00edt v\u1edbi li\u1ec1u r\u1ea5t cao.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb vi\u00eam m\u0169i d\u1ecb \u1ee9ng quanh n\u0103m ho\u1eb7c theo m\u00f9a:<\/p>\n<p>T\u00e1c d\u1ee5ng c\u1ee7a fluticasone propionate trong \u0111i\u1ec1u tr\u1ecb vi\u00eam m\u0169i d\u1ecb \u1ee9ng l\u00e0 do thu\u1ed1c l\u00e0m gi\u1ea3m gi\u1ea3i ph\u00f3ng c\u00e1c ch\u1ea5t trung gian g\u00e2y vi\u00eam, c\u00e1c ch\u1ea5t \u0111\u00f3 t\u1ea1o ra c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u01b0 ng\u1ee9a, h\u1eaft h\u01a1i, ch\u1ea3y n\u01b0\u1edbc m\u0169i v\u00e0 ph\u00f9.<\/p>\n<p>Ng\u01b0\u1eddi b\u1ec7nh ph\u1ea3i s\u1eed d\u1ee5ng thu\u1ed1c theo kho\u1ea3ng c\u00e1ch \u0111\u1ec1u \u0111\u1eb7n nh\u01b0 h\u01b0\u1edbng d\u1eabn v\u00ec hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb t\u00f9y thu\u1ed9c v\u00e0o vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c \u0111\u1ec1u \u0111\u1eb7n.<\/p>\n<p>C\u00e1c tri\u1ec7u ch\u1ee9ng th\u01b0\u1eddng nh\u1eb9 b\u1edbt trong v\u00f2ng 12-48 gi\u1edd sau khi b\u1eaft \u0111\u1ea7u d\u00f9ng thu\u1ed1c, tuy nhi\u00ean \u1edf m\u1ed9t s\u1ed1 ng\u01b0\u1eddi b\u1ec7nh ph\u1ea3i t\u1edbi 2-4 ng\u00e0y sau m\u1edbi \u0111\u1ea1t \u0111\u01b0\u1ee3c hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb t\u1ed1i \u0111a.<\/p>\n<p>C\u00f3 th\u1ec3 c\u1ea7n ph\u1ea3i \u0111i\u1ec1u tr\u1ecb th\u00eam b\u1eb1ng u\u1ed1ng c\u00e1c thu\u1ed1c kh\u00e1ng histamine v\u00e0\/ho\u1eb7c d\u00f9ng t\u1ea1i ch\u1ed7 thu\u1ed1c ch\u1ed1ng ng\u1ea1t m\u0169i cho \u0111\u1ebfn khi \u0111\u1ea1t \u0111\u01b0\u1ee3c \u0111\u00e1p \u1ee9ng l\u00e2m s\u00e0ng.<\/p>\n<p>\u1ede m\u1ed9t s\u1ed1 ng\u01b0\u1eddi b\u1ecb vi\u00eam m\u0169i d\u1ecb \u1ee9ng quanh n\u0103m ho\u1eb7c theo m\u00f9a, \u0111\u1eb7c bi\u1ec7t nh\u1eefng ng\u01b0\u1eddi \u0111ang c\u00f3 b\u1ec7nh hen, c\u00f3 th\u1ec3 c\u1ea7n ph\u1ea3i \u0111i\u1ec1u tr\u1ecb \u0111\u1ed3ng th\u1eddi li\u00ean t\u1ee5c v\u1edbi corticosteroid theo \u0111\u01b0\u1eddng u\u1ed1ng ho\u1eb7c h\u00edt qua v\u00f9ng mi\u1ec7ng, thu\u1ed1c gi\u00e3n ph\u1ebf qu\u1ea3n, kh\u00e1ng histamin, ch\u1ed1ng ng\u1ea1t m\u0169i \u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c hi\u1ec7u qu\u1ea3 t\u1ed1i \u0111a.<\/p>\n<p>C\u00f3 th\u1ec3 x\u1ea3y ra gi\u1ea3m nhanh t\u00e1c d\u1ee5ng ch\u1ed1ng vi\u00eam c\u1ee7a c\u00e1c corticosteroid khi d\u00f9ng nh\u1eafc l\u1ea1i m\u1eb7c d\u00f9 ch\u01b0a \u0111\u01b0\u1ee3c bi\u1ebft r\u00f5 t\u1ea7m quan tr\u1ecdng tr\u00ean l\u00e2m s\u00e0ng.<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>Fluticason propionat l\u00e0 m\u1ed9t corticosteroid t\u1ed5ng h\u1ee3p c\u00f3 nguy\u00ean t\u1eed fluor g\u1eafn v\u00e0o khung steroid. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a c\u00e1c corticosteroid d\u00f9ng t\u1ea1i ch\u1ed7 l\u00e0 s\u1ef1 ph\u1ed1i h\u1ee3p 3 t\u00ednh ch\u1ea5t quan tr\u1ecdng: ch\u1ed1ng vi\u00eam, ch\u1ed1ng ng\u1ee9a v\u00e0 t\u00e1c d\u1ee5ng co m\u1ea1ch. T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c m\u1ed9t ph\u1ea7n do li\u00ean k\u1ebft v\u1edbi th\u1ee5 th\u1ec3 steroid. C\u00e1c corticosteroid gi\u1ea3m vi\u00eam b\u1eb1ng c\u00e1ch l\u00e0m \u1ed5n \u0111\u1ecbnh m\u00e0ng lysosom c\u1ee7a b\u1ea1ch c\u1ea7u, \u1ee9c ch\u1ebf t\u1eadp trung \u0111\u1ea1i th\u1ef1c b\u00e0o trong c\u00e1c v\u00f9ng b\u1ecb vi\u00eam, gi\u1ea3m s\u1ef1 b\u00e1m d\u00ednh c\u1ee7a b\u1ea1ch c\u1ea7u v\u1edbi n\u1ed9i m\u00f4 mao m\u1ea1ch, gi\u1ea3m t\u00ednh th\u1ea5m th\u00e0nh mao m\u1ea1ch, gi\u1ea3m c\u00e1c th\u00e0nh ph\u1ea7n b\u1ed5 th\u1ec3, \u0111\u1ed1i kh\u00e1ng t\u00e1c d\u1ee5ng c\u1ee7a histamin v\u00e0 s\u1ef1 gi\u1ea3i ph\u00f3ng kinin t\u1eeb c\u00e1c c\u01a1 ch\u1ea5t, gi\u1ea3m t\u0103ng sinh c\u00e1c nguy\u00ean b\u00e0o s\u1ee3i, gi\u1ea3m l\u1eafng \u0111\u1ecdng colagen v\u00e0 sau \u0111\u00f3 gi\u1ea3m t\u1ea1o th\u00e0nh s\u1eb9o \u1edf m\u00f4.<\/p>\n<p>C\u00e1c corticosteroid, \u0111\u1eb7c bi\u1ec7t l\u00e0 c\u00e1c corticosteroid c\u00f3 fluor c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng ph\u00e2n b\u00e0o \u1edf nguy\u00ean b\u00e0o s\u1ee3i da v\u00e0 bi\u1ec3u b\u00ec.<\/p>\n<p>Fluticason propionat l\u00e0 corticosteroid d\u00f9ng t\u1ea1i ch\u1ed7 c\u00f3 \u0111\u1ed9 thanh th\u1ea3i qua gan b\u01b0\u1edbc \u0111\u1ea7u r\u1ea5t l\u1edbn, d\u1eabn \u0111\u1ebfn sinh kh\u1ea3 d\u1ee5ng to\u00e0n th\u00e2n r\u1ea5t th\u1ea5p. \u0110i\u1ec1u \u0111\u00f3 l\u00e0m gi\u1ea3m nguy c\u01a1 t\u00e1c d\u1ee5ng ph\u1ee5 to\u00e0n th\u00e2n sau khi d\u00f9ng thu\u1ed1c theo \u0111\u01b0\u1eddng h\u00edt, ngay c\u1ea3 khi h\u00edt v\u1edbi li\u1ec1u r\u1ea5t cao.<\/p>\n<p><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/p>\n<p><strong>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/strong><\/p>\n<p><em>H\u1ea5p thu:<\/em> Sau khi x\u1ecbt m\u0169i v\u1edbi fluticasone propionate (200microgram\/ng\u00e0y), \u1edf h\u1ea7u h\u1ebft c\u00e1c b\u1ec7nh nh\u00e2n n\u1ed3ng \u0111\u1ed9 t\u1ed1i \u0111a trong huy\u1ebft t\u01b0\u01a1ng \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh l\u00e0 kh\u00f4ng \u0111\u1ecbnh l\u01b0\u1ee3ng \u0111\u01b0\u1ee3c (d\u01b0\u1edbi 0.01nanogram\/mL). Cmax cao nh\u1ea5t \u0111\u00e3 quan s\u00e1t \u0111\u01b0\u1ee3c l\u00e0 0.017nanogram\/mL. H\u1ea5p thu tr\u1ef1c ti\u1ebfp t\u1eeb m\u0169i l\u00e0 kh\u00f4ng \u0111\u00e1ng k\u1ec3 do \u0111\u1ed9 h\u00f2a tan trong n\u01b0\u1edbc th\u1ea5p v\u00e0 ph\u1ea7n l\u1edbn li\u1ec1u thu\u1ed1c th\u01b0\u1eddng b\u1ecb nu\u1ed1t. Sinh kh\u1ea3 d\u1ee5ng tuy\u1ec7t \u0111\u1ed1i \u0111\u01b0\u1eddng u\u1ed1ng l\u00e0 kh\u00f4ng \u0111\u00e1ng k\u1ec3 (d\u01b0\u1edbi 1%) do c\u00f3 m\u1ed9t s\u1ef1 k\u1ebft h\u1ee3p gi\u1eefa h\u1ea5p thu kh\u00f4ng ho\u00e0n to\u00e0n qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a v\u00e0 chuy\u1ec3n h\u00f3a l\u1ea7n \u0111\u1ea7u m\u1ea1nh. H\u1ea5p thu to\u00e0n th\u00e2n c\u00f3 \u0111\u01b0\u1ee3c t\u1eeb h\u1ea5p thu t\u1ea1i m\u0169i v\u00e0 h\u1ea5p thu qua \u0111\u01b0\u1eddng u\u1ed1ng c\u1ee7a l\u01b0\u1ee3ng thu\u1ed1c nu\u1ed1t v\u00e0o do v\u1eady \u0111\u1ec1u kh\u00f4ng \u0111\u00e1ng k\u1ec3.<\/p>\n<p><em>Ph\u00e2n b\u1ed1:<\/em> Fluticasone propionate c\u00f3 th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 l\u1edbn \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh (x\u1ea5p x\u1ec9 318L). Li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng \u1edf m\u1ee9c cao trung b\u00ecnh (91%).<\/p>\n<p><em>Chuy\u1ec3n h\u00f3a:<\/em> Fluticasone propionate nhanh ch\u00f3ng \u0111\u01b0\u1ee3c lo\u1ea1i kh\u1ecfi tu\u1ea7n h\u00f2a to\u00e0n th\u00e2n, ch\u1ee7 y\u1ebfu qua chuy\u1ec3n h\u00f3a t\u1ea1i gan th\u00e0nh ch\u1ea5t chuy\u1ec3n h\u00f3a kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh carboxylic acid, v\u00e0 qua CYP3A4 &#8211; m\u1ed9t men c\u1ee7a h\u1ec7 cytochrome P450. L\u01b0\u1ee3ng fluticasone propionate nu\u1ed1t v\u00e0o c\u0169ng \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a l\u1ea7n \u0111\u1ea7u m\u1ea1nh. N\u00ean ch\u00fa \u00fd khi s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf m\u1ea1nh CYP3A4 nh\u01b0 ketoconazole v\u00e0 ritonavir do c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m t\u0103ng ph\u01a1i nhi\u1ec5m to\u00e0n th\u00e2n v\u1edbi fluticasone propionate.<\/p>\n<p><em>Th\u1ea3i tr\u1eeb:<\/em> Th\u1ea3i tr\u1eeb c\u1ee7a fluticasone propionate khi d\u00f9ng theo \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch l\u00e0 tuy\u1ebfn t\u00ednh trong kho\u1ea3ng li\u1ec1u t\u1eeb 250 cho \u0111\u1ebfn 1000microgram v\u00e0 \u0111\u01b0\u1ee3c \u0111\u1eb7c tr\u01b0ng b\u1edfi thanh th\u1ea3i trong huy\u1ebft t\u01b0\u01a1ng cao (CL=1.1L\/ph\u00fat). N\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng gi\u1ea3m kho\u1ea3ng 98% sau 3 \u0111\u1ebfn 4 gi\u1edd v\u00e0 sau th\u1eddi gian b\u00e1n h\u1ee7y 7.8 gi\u1edd, n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng ch\u1ec9 c\u00f2n th\u1ea5p. Thanh th\u1ea3i qua th\u1eadn c\u1ee7a fluticasone propionate l\u00e0 kh\u00f4ng \u0111\u00e1ng k\u1ec3 (d\u01b0\u1edbi 0.2%) v\u00e0 d\u01b0\u1edbi 5% d\u01b0\u1edbi d\u1ea1ng ch\u1ea5t chuy\u1ec3n h\u00f3a carboxylic acid. \u0110\u01b0\u1eddng th\u1ea3i tr\u1eeb ch\u00ednh l\u00e0 b\u00e0i ti\u1ebft fluticasone propionate v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a n\u00f3 theo \u0111\u01b0\u1eddng m\u1eadt.<\/p>\n<p><strong>5.3 Gi\u1ea3i th\u00edch: <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong>5.4 Thay th\u1ebf thu\u1ed1c : <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng <\/em><\/strong><strong><em>ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/strong><\/p>\n<p><strong>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/strong><\/p>\n<p>T\u00e1 d\u01b0\u1ee3c: Dextrose (d\u1ea1ng khan), Microcrystalline cellulose v\u00e0 carboxymethylcellulose sodium (Avicel RC591), Phenylethyl alcohol, Benzalkonium chloride, Polysorbate 80, Acid hydrochloric lo\u00e3ng, N\u01b0\u1edbc tinh khi\u1ebft.<\/p>\n<p><strong>6.2. T\u01b0\u01a1ng k\u1ef5 :<\/strong><\/p>\n<p>Kh\u00f4ng \u00e1p d\u1ee5ng.<\/p>\n<p><strong>6.3. B\u1ea3o qu\u1ea3n: <\/strong><\/p>\n<p>N\u01a1i kh\u00f4, tr\u00e1nh \u00e1nh s\u00e1ng, nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30\u00b0C.<\/p>\n<p><strong>6.4. Th\u00f4ng tin kh\u00e1c :<\/strong><\/p>\n<p><em>An to\u00e0n ti\u1ec1n l\u00e2m s\u00e0ng <\/em><\/p>\n<p>Ch\u1ec9 th\u1ea5y xu\u1ea5t hi\u1ec7n \u0111\u1ed9c t\u00ednh \u0111i\u1ec3n h\u00ecnh c\u1ee7a corticosteroid m\u1ea1nh, v\u00e0 ch\u1ec9 xu\u1ea5t hi\u1ec7n khi d\u00f9ng nh\u1eefng li\u1ec1u v\u01b0\u1ee3t qu\u00e1 li\u1ec1u \u0111i\u1ec1u tr\u1ecb \u0111\u1ec1 ngh\u1ecb. Kh\u00f4ng c\u00f3 \u1ea3nh h\u01b0\u1edfng n\u00e0o m\u1edbi \u0111\u01b0\u1ee3c ghi nh\u1eadn trong c\u00e1c th\u1eed nghi\u1ec7m \u0111\u1ed9c t\u00ednh li\u1ec1u l\u1eb7p l\u1ea1i, c\u00e1c nghi\u00ean c\u1ee9u \u0111\u1ed9c t\u00ednh tr\u00ean h\u1ec7 sinh s\u1ea3n ho\u1eb7c c\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 kh\u1ea3 n\u0103ng g\u00e2y qu\u00e1i thai.<\/p>\n<p>Fluticasone propionate kh\u00f4ng g\u00e2y \u0111\u1ed9t bi\u1ebfn gen tr\u00ean c\u1ea3 invitro v\u00e0 invivo v\u00e0 kh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y ung th\u01b0 \u1edf lo\u00e0i g\u1eb7m nh\u1ea5m. Fluticasone propionate kh\u00f4ng g\u00e2y k\u00edch \u1ee9ng v\u00e0 kh\u00f4ng g\u00e2y nh\u1ea1y c\u1ea3m \u1edf \u0111\u1ed9ng v\u1eadt th\u00ed nghi\u1ec7m.<\/p>\n<p><strong>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/strong><\/p>\n<p>D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n<p>Ho\u1eb7c HDSD Thu\u1ed1c.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Fluticasone propionate Ph\u00e2n lo\u1ea1i: Thu\u1ed1c Corticosteroids d\u00f9ng \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p. Nh\u00f3m ph\u00e1p l\u00fd: Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine) M\u00e3 ATC (Anatomical Therapeutic Chemical): D07AC17, R01AD08, R03BA05. Brand name: FLIXONASE H\u00e3ng s\u1ea3n xu\u1ea5t : GlaxoSmithKline 2. D\u1ea1ng b\u00e0o ch\u1ebf [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":11293,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[370],"tags":[772],"class_list":["post-7128","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc-goc","tag-fluticasone-propionate"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/7128","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=7128"}],"version-history":[{"count":4,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/7128\/revisions"}],"predecessor-version":[{"id":52162,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/7128\/revisions\/52162"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/11293"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=7128"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=7128"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=7128"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}