{"id":6880,"date":"2019-04-02T16:02:03","date_gmt":"2019-04-02T09:02:03","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=6880"},"modified":"2025-01-08T23:02:29","modified_gmt":"2025-01-08T16:02:29","slug":"domperidone-motilium","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/domperidone-motilium\/","title":{"rendered":"Domperidone &#8211; Motilium\/Motilium-M"},"content":{"rendered":"<p><strong>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: <\/strong><\/p>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <a href=\"https:\/\/pharmog.com\/wp\/domperidone\/\">Domperidone<\/a><\/strong><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u1ed1c ch\u1ed1ng n\u00f4n nh\u00f3m \u0111\u1ed1i kh\u00e1ng dopamin.<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): A03FA03.<\/p>\n<p><strong><em>Brand name<\/em><\/strong>, MOTILIUM, MOTILIUM-M<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: Janssen Pharmaceutica NV<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>2. D\u1ea1ng b\u00e0o ch\u1ebf H\u00e0m l\u01b0\u1ee3ng: <\/strong><\/p>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>Vi\u00ean n\u00e9n: 10 mg.<\/p>\n<p>H\u1ed7n d\u1ecbch u\u1ed1ng: 1 mg\/1 ml.<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>MOTILIUM-M 10MG<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean n\u00e9n bao phim c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Domperidone<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>10 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-6881\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/04\/word-image-140.png\" width=\"594\" height=\"424\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/04\/word-image-140.png 870w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/04\/word-image-140-300x214.png 300w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/04\/word-image-140-768x548.png 768w\" sizes=\"auto, (max-width: 594px) 100vw, 594px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>MOTILIUM<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i ml h\u1ed7n d\u1ecbch c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Domperidone<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>1 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-21488 size-full\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/04\/Motilium.jpg\" alt=\"\" width=\"376\" height=\"395\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/04\/Motilium.jpg 376w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/04\/Motilium-286x300.jpg 286w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/04\/Motilium-152x160.jpg 152w\" sizes=\"auto, (max-width: 376px) 100vw, 376px\" \/><\/p>\n<p><strong>3. Video by Pharmog:<\/strong><\/p>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<p><strong>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng: <\/strong><\/p>\n<p><strong>4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>MOTILIUM \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng n\u00f4n v\u00e0 bu\u1ed3n n\u00f4n.<\/p>\n<p><strong>4.2. Li\u1ec1u d\u00f9ng C\u00e1ch d\u00f9ng:<\/strong><\/p>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p>MOTILIUM ch\u1ec9 n\u00ean s\u1eed d\u1ee5ng li\u1ec1u th\u1ea5p nh\u1ea5t c\u00f3 hi\u1ec7u qu\u1ea3 trong th\u1eddi gian ng\u1eafn nh\u1ea5t \u0111\u1ec3 ki\u1ec3m so\u00e1t n\u00f4n v\u00e0 bu\u1ed3n n\u00f4n.<\/p>\n<p>N\u00ean u\u1ed1ng MOTILIUM tr\u01b0\u1edbc b\u1eefa \u0103n. N\u1ebfu u\u1ed1ng sau b\u1eefa \u0103n, thu\u1ed1c c\u00f3 th\u1ec3 b\u1ecb ch\u1eadm h\u1ea5p thu. B\u1ec7nh nh\u00e2n n\u00ean u\u1ed1ng thu\u1ed1c v\u00e0o th\u1eddi gian c\u1ed1 \u0111\u1ecbnh. N\u1ebfu b\u1ecb qu\u00ean 1 li\u1ec1u, c\u00f3 th\u1ec3 b\u1ecf qua li\u1ec1u \u0111\u00f3 v\u00e0 ti\u1ebfp t\u1ee5c d\u00f9ng thu\u1ed1c theo l\u1ecbch tr\u00ecnh nh\u01b0 c\u0169. Kh\u00f4ng n\u00ean t\u0103ng li\u1ec1u g\u1ea5p \u0111\u00f4i \u0111\u1ec3 b\u00f9 cho li\u1ec1u \u0111\u00e3 qu\u00ean.<\/p>\n<p>Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb t\u1ed1i \u0111a kh\u00f4ng n\u00ean v\u01b0\u1ee3t qu\u00e1 m\u1ed9t tu\u1ea7n.<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p><em>Ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb v\u1ecb th\u00e0nh ni\u00ean (t\u1eeb 12 tu\u1ed5i tr\u1edf l\u00ean v\u00e0 c\u00e2n n\u1eb7ng t\u1eeb 35 kg tr\u1edf l\u00ean)<\/em><\/p>\n<p>10mg l\u00ean \u0111\u1ebfn 3 l\u1ea7n 1 ng\u00e0y v\u1edbi li\u1ec1u t\u1ed1i \u0111a l\u00e0 30mg m\u1ed7i ng\u00e0y.<\/p>\n<p><em>Tr\u1ebb s\u01a1 sinh, tr\u1ebb nh\u1ecf, tr\u1ebb em (d\u01b0\u1edbi 12 tu\u1ed5i) v\u00e0 tr\u1ebb v\u1ecb th\u00e0nh ni\u00ean c\u00e2n n\u1eb7ng d\u01b0\u1edbi 35 kg<\/em><\/p>\n<p>Do c\u1ea7n d\u00f9ng li\u1ec1u ch\u00ednh x\u00e1c n\u00ean c\u00e1c d\u1ea1ng thu\u1ed1c vi\u00ean n\u00e9n kh\u00f4ng th\u00edch h\u1ee3p cho tr\u1ebb nh\u1ecf v\u00e0 tr\u1ebb v\u1ecb th\u00e0nh ni\u00ean c\u00e2n n\u1eb7ng d\u01b0\u1edbi 35 kg. N\u00ean d\u00f9ng d\u1ea1ng h\u1ed7n d\u1ecbch u\u1ed1ng cho nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y.<\/p>\n<p><em>B\u1ec7nh nh\u00e2n suy gan<\/em><\/p>\n<p>MOTILIUM ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh v\u1edbi b\u1ec7nh nh\u00e2n suy gan trung b\u00ecnh v\u00e0 n\u1eb7ng (xem\u00a0<em>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh).<\/em>\u00a0Kh\u00f4ng c\u1ea7n hi\u1ec7u ch\u1ec9nh li\u1ec1u \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n suy gan nh\u1eb9.<\/p>\n<p><em>B\u1ec7nh nh\u00e2n suy th\u1eadn<\/em><\/p>\n<p>Do th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a Domperidon b\u1ecb k\u00e9o d\u00e0i \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng n\u00ean n\u1ebfu d\u00f9ng nh\u1eafc l\u1ea1i s\u1ed1 l\u1ea7n \u0111\u01b0a thu\u1ed1c c\u1ee7a MOTILIUM c\u1ea7n gi\u1ea3m xu\u1ed1ng c\u00f2n 1 \u0111\u1ebfn 2 l\u1ea7n\/ng\u00e0y v\u00e0 hi\u1ec7u ch\u1ec9nh li\u1ec1u t\u00f9y thu\u1ed9c v\u00e0o m\u1ee9c \u0111\u1ed9 suy th\u1eadn.<\/p>\n<p><strong>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>Domperidon c\u1ea7n ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p sau:<\/p>\n<p>\u0110\u00e3 bi\u1ebft qu\u00e1 m\u1eabn v\u1edbi Domperidon ho\u1eb7c b\u1ea5t c\u1ee9 t\u00e1 d\u01b0\u1ee3c n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p>U tuy\u1ebfn y\u00ean ti\u1ebft prolactin (prolactinoma).<\/p>\n<p>Khi vi\u1ec7c k\u00edch th\u00edch v\u1eadn \u0111\u1ed9ng d\u1ea1 d\u00e0y c\u00f3 th\u1ec3 g\u00e2y nguy hi\u1ec3m nh\u01b0 \u0111ang b\u1ecb xu\u1ea5t huy\u1ebft ti\u00eau h\u00f3a, t\u1eafc ru\u1ed9t c\u01a1 h\u1ecdc ho\u1eb7c th\u1ee7ng ti\u00eau h\u00f3a.<\/p>\n<p>B\u1ec7nh nh\u00e2n suy gan trung b\u00ecnh hay n\u1eb7ng (xem\u00a0<em>\u0110\u1eb7c t\u00ednh D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc).<\/em><\/p>\n<p>B\u1ec7nh nh\u00e2n c\u00f3 th\u1eddi gian d\u1eabn truy\u1ec1n xung \u0111\u1ed9ng tim k\u00e9o d\u00e0i, \u0111\u1eb7c bi\u1ec7t l\u00e0 kho\u1ea3ng QT, b\u1ec7nh nh\u00e2n c\u00f3 r\u1ed1i lo\u1ea1n \u0111i\u1ec7n gi\u1ea3i r\u00f5 r\u1ec7t ho\u1eb7c b\u1ec7nh nh\u00e2n \u0111ang c\u00f3 b\u1ec7nh tim m\u1ea1ch nh\u01b0 suy tim sung huy\u1ebft, (xem\u00a0<em>C\u1ea3nh b\u00e1o v\u00e0 th\u1eadn tr\u1ecdng).<\/em><\/p>\n<p>D\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c k\u00e9o d\u00e0i kho\u1ea3ng QT (xem\u00a0<em>T\u01b0\u01a1ng t\u00e1c v\u1edbi<\/em>\u00a0c\u00e1c\u00a0<em>thu\u1ed1c kh\u00e1c v\u00e0 c\u00e1c lo\u1ea1i t\u01b0\u01a1ng t\u00e1c kh\u00e1c).<\/em><\/p>\n<p>D\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf CYP3A4 m\u1ea1nh (kh\u00f4ng ph\u1ee5 thu\u1ed9c t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i kho\u1ea3ng QT) (xem\u00a0<em>T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c v\u00e0<\/em>\u00a0c\u00e1c\u00a0<em>lo\u1ea1i t\u01b0\u01a1ng t\u00e1c kh\u00e1c).<\/em><\/p>\n<p><strong>4.4 Th\u1eadn tr\u1ecdng:<\/strong><\/p>\n<p><em>Suy th\u1eadn<\/em><\/p>\n<p>Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a Domperidon b\u1ecb k\u00e9o d\u00e0i \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng. Trong tr\u01b0\u1eddng h\u1ee3p d\u00f9ng nh\u1eafc l\u1ea1i, t\u1ea7n su\u1ea5t \u0111\u01b0a Domperidon c\u1ea7n gi\u1ea3m xu\u1ed1ng c\u00f2n 1 \u0111\u1ebfn 2 l\u1ea7n\/ng\u00e0y t\u00f9y thu\u1ed9c m\u1ee9c \u0111\u1ed9 suy th\u1eadn, v\u00e0 c\u00f3 th\u1ec3 hi\u1ec7u ch\u1ec9nh li\u1ec1u n\u1ebfu c\u1ea7n.<\/p>\n<p><em>T\u00e1c d\u1ee5ng tr\u00ean tim m\u1ea1ch<\/em><\/p>\n<p>Domperidon l\u00e0m k\u00e9o d\u00e0i kho\u1ea3ng QT tr\u00ean \u0111i\u1ec7n t\u00e2m \u0111\u1ed3. Trong qu\u00e1 tr\u00ecnh gi\u00e1m s\u00e1t h\u1eadu m\u00e3i, c\u00f3 r\u1ea5t \u00edt b\u00e1o c\u00e1o v\u1ec1 k\u00e9o d\u00e0i kho\u1ea3ng QT v\u00e0 xo\u1eafn \u0111\u1ec9nh li\u00ean quan \u0111\u1ebfn s\u1eed d\u1ee5ng Domperidon. C\u00e1c b\u00e1o c\u00e1o n\u00e0y c\u00f3 c\u00e1c y\u1ebfu t\u1ed1 g\u00e2y nhi\u1ec5u nh\u01b0 r\u1ed1i lo\u1ea1n \u0111i\u1ec7n gi\u1ea3i hay c\u00e1c thu\u1ed1c d\u00f9ng \u0111\u1ed3ng th\u1eddi, (xem\u00a0<em>T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n).<\/em><\/p>\n<p>C\u00e1c nghi\u00ean c\u1ee9u d\u1ecbch t\u1ec3 cho th\u1ea5y Domperidon c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 lo\u1ea1n nh\u1ecbp th\u1ea5t nghi\u00eam tr\u1ecdng ho\u1eb7c \u0111\u1ed9t t\u1eed do tim m\u1ea1ch (xem\u00a0<em>T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n).\u00a0<\/em>Nguy c\u01a1 n\u00e0y cao h\u01a1n \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n tr\u00ean 60 tu\u1ed5i, b\u1ec7nh nh\u00e2n d\u00f9ng li\u1ec1u h\u00e0ng ng\u00e0y l\u1edbn h\u01a1n 30mg v\u00e0 b\u1ec7nh nh\u00e2n d\u00f9ng \u0111\u1ed3ng th\u1eddi thu\u1ed1c k\u00e9o d\u00e0i kho\u1ea3ng QT ho\u1eb7c thu\u1ed1c \u1ee9c ch\u1ebf CYP3A4.<\/p>\n<p><em>S\u1eed d\u1ee5ng Domperidon v\u1edbi li\u1ec1u th\u1ea5p nh\u1ea5t c\u00f3 hi\u1ec7u qu\u1ea3 \u1edf ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em.<\/em><\/p>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh Domperidon cho nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 th\u1eddi gian d\u1eabn truy\u1ec1n xung \u0111\u1ed9ng tim k\u00e9o d\u00e0i, \u0111\u1eb7c bi\u1ec7t l\u00e0 kho\u1ea3ng QT, b\u1ec7nh nh\u00e2n c\u00f3 r\u1ed1i lo\u1ea1n \u0111i\u1ec7n gi\u1ea3i r\u00f5 r\u1ec7t (h\u1ea1 kali m\u00e1u, t\u0103ng kali m\u00e1u, h\u1ea1 magnesi m\u00e1u), nh\u1ecbp tim ch\u1eadm ho\u1eb7c b\u1ec7nh nh\u00e2n \u0111ang m\u1eafc b\u1ec7nh tim m\u1ea1ch nh\u01b0 suy tim sung huy\u1ebft do nguy c\u01a1 gia t\u0103ng r\u1ed1i lo\u1ea1n nh\u1ecbp th\u1ea5t (xem\u00a0<em>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh).<\/em>\u00a0R\u1ed1i lo\u1ea1n \u0111i\u1ec7n gi\u1ea3i (h\u1ea1 kali m\u00e1u, t\u0103ng kali m\u00e1u, h\u1ea1 magnesi m\u00e1u) ho\u1eb7c nh\u1ecbp tim ch\u1eadm \u0111\u00e3 \u0111\u01b0\u1ee3c bi\u1ebft l\u00e0 y\u1ebfu t\u1ed1 l\u00e0m t\u0103ng nguy c\u01a1 lo\u1ea1n nh\u1ecbp tim.<\/p>\n<p>C\u1ea7n ng\u1eebng \u0111i\u1ec1u tr\u1ecb v\u1edbi Domperidon v\u00e0 trao \u0111\u1ed5i l\u1ea1i v\u1edbi c\u00e1n b\u1ed9 y t\u1ebf n\u1ebfu c\u00f3 b\u1ea5t k\u1ef3 tri\u1ec7u ch\u1ee9ng hay d\u1ea5u hi\u1ec7u n\u00e0o c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn lo\u1ea1n nh\u1ecbp tim.<\/p>\n<p>Khuy\u00ean b\u1ec7nh nh\u00e2n nhanh ch\u00f3ng b\u00e1o c\u00e1o b\u1ea5t k\u1ef3 c\u00e1c tri\u1ec7u ch\u1ee9ng n\u00e0o tr\u00ean tim m\u1ea1ch.<\/p>\n<p><em>Tr\u1ebb em<\/em><\/p>\n<p>M\u1eb7c d\u00f9 t\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean th\u1ea7n kinh l\u00e0 hi\u1ebfm g\u1eb7p (xem\u00a0<em>T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n),<\/em>\u00a0nguy c\u01a1 g\u1eb7p t\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean th\u1ea7n kinh cao h\u01a1n \u1edf tr\u1ebb nh\u1ecf do ch\u1ee9c n\u0103ng chuy\u1ec3n h\u00f3a v\u00e0 h\u00e0ng r\u00e0o m\u00e1u n\u00e3o ch\u01b0a ph\u00e1t tri\u1ec3n \u0111\u1ea7y \u0111\u1ee7 trong nh\u1eefng th\u00e1ng \u0111\u1ea7u \u0111\u1eddi. Do \u0111\u00f3, khuy\u1ebfn c\u00e1o c\u1ea7n x\u00e1c \u0111\u1ecbnh li\u1ec1u ch\u00ednh x\u00e1c v\u00e0 theo d\u00f5i ch\u1eb7t ch\u1ebd khi d\u00f9ng cho tr\u1ebb s\u01a1 sinh, tr\u1ebb nh\u1ecf v\u00e0 tr\u1ebb em (xem\u00a0<em>Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch d\u00f9ng).<\/em><\/p>\n<p>Qu\u00e1 li\u1ec1u c\u00f3 th\u1ec3 g\u00e2y c\u00e1c tri\u1ec7u ch\u1ee9ng ngo\u1ea1i th\u00e1p \u1edf tr\u1ebb em, nh\u01b0ng c\u0169ng n\u00ean xem x\u00e9t \u0111\u1ebfn c\u00e1c nguy\u00ean nh\u00e2n kh\u00e1c.<\/p>\n<p><em>Ch\u00fa \u00fd khi s\u1eed d\u1ee5ng<\/em><\/p>\n<p>Vi\u00ean n\u00e9n bao phim c\u00f3 ch\u1ee9a lactose do \u0111\u00f3 c\u00f3 th\u1ec3 kh\u00f4ng ph\u00f9 h\u1ee3p cho b\u1ec7nh nh\u00e2n kh\u00f4ng dung n\u1ea1p v\u1edbi lactose, kh\u00f4ng dung n\u1ea1p v\u1edbi galactose do thi\u1ebfu men chuy\u1ec3n h\u00f3a galactose hay k\u00e9m h\u1ea5p thu glucose\/galactose.<\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>MOTILIUM kh\u00f4ng \u1ea3nh h\u01b0\u1edfng ho\u1eb7c \u1ea3nh h\u01b0\u1edfng kh\u00f4ng \u0111\u00e1ng k\u1ec3 l\u00ean kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/strong><\/p>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: B2<\/p>\n<p>US FDA pregnancy category: NA<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>C\u00f3 \u00edt d\u1eef li\u1ec7u sau khi \u0111\u01b0a thu\u1ed1c ra th\u1ecb tr\u01b0\u1eddng v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng Domperidon \u1edf ph\u1ee5 n\u1eef c\u00f3 thai. M\u1ed9t nghi\u00ean c\u1ee9u \u1edf chu\u1ed9t cho th\u1ea5y \u0111\u1ed9c t\u00ednh tr\u00ean h\u1ec7 sinh s\u1ea3n \u1edf li\u1ec1u \u0111\u1ed9c cao \u1edf chu\u1ed9t m\u1eb9. Nguy c\u01a1 ti\u1ec1m t\u00e0ng \u1edf ng\u01b0\u1eddi ch\u01b0a \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn. V\u00ec v\u1eady, ch\u1ec9 n\u00ean d\u00f9ng MOTILIUM trong thai k\u1ef3 khi \u0111\u00e1nh gi\u00e1 v\u00e0 ti\u00ean l\u01b0\u1ee3ng \u0111\u01b0\u1ee3c l\u1ee3i \u00edch \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>Domperidon b\u00e0i ti\u1ebft qua s\u1eefa m\u1eb9 v\u00e0 tr\u1ebb b\u00fa m\u1eb9 nh\u1eadn \u0111\u01b0\u1ee3c \u00edt h\u01a1n 0.1% li\u1ec1u theo c\u00e2n n\u1eb7ng c\u1ee7a m\u1eb9. C\u00e1c t\u00e1c d\u1ee5ng b\u1ea5t l\u1ee3i, \u0111\u1eb7c bi\u1ec7t l\u00e0 t\u00e1c d\u1ee5ng tr\u00ean tim m\u1ea1ch v\u1eabn c\u00f3 th\u1ec3 x\u1ea3y ra sau khi tr\u1ebb b\u00fa s\u1eefa m\u1eb9. C\u1ea7n c\u00e2n nh\u1eafc l\u1ee3i \u00edch c\u1ee7a vi\u1ec7c cho tr\u1ebb b\u00fa s\u1eefa m\u1eb9 v\u00e0 l\u1ee3i \u00edch c\u1ee7a vi\u1ec7c \u0111i\u1ec1u tr\u1ecb cho m\u1eb9 \u0111\u1ec3 quy\u1ebft \u0111\u1ecbnh ng\u1eebng cho con b\u00fa hay ng\u1eebng\/tr\u00e1nh \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Domperidon. C\u1ea7n th\u1eadn tr\u1ecdng trong tr\u01b0\u1eddng h\u1ee3p c\u00f3 y\u1ebfu t\u1ed1 nguy c\u01a1 l\u00e0m k\u00e9o d\u00e0i kho\u1ea3ng QT \u1edf tr\u1ebb b\u00fa m\u1eb9.<\/p>\n<p><strong>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/strong><\/p>\n<p>T\u00ednh an to\u00e0n c\u1ee7a Domperidon \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u00e0 c\u00e1c kinh nghi\u1ec7m h\u1eadu m\u00e3i. C\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng tr\u00ean 1275 b\u1ec7nh nh\u00e2n b\u1ecb ch\u1ee9ng kh\u00f3 ti\u00eau, tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y th\u1ef1c qu\u1ea3n (GERD), h\u1ed9i ch\u1ee9ng ru\u1ed9t k\u00edch th\u00edch (IBS), bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n ho\u1eb7c c\u00e1c t\u00ecnh tr\u1ea1ng b\u1ec7nh l\u00fd li\u00ean quan kh\u00e1c trong 31 nghi\u00ean c\u1ee9u m\u00f9 \u0111\u00f4i, c\u00f3 \u0111\u1ed1i ch\u1ee9ng gi\u1ea3 d\u01b0\u1ee3c. T\u1ea5t c\u1ea3 c\u00e1c b\u1ec7nh nh\u00e2n t\u1eeb 15 tu\u1ed5i tr\u1edf l\u00ean v\u00e0 \u0111\u01b0\u1ee3c u\u1ed1ng \u00edt nh\u1ea5t 1 li\u1ec1u MOTILIUM (Domperidon base). Li\u1ec1u trung b\u00ecnh h\u1eb1ng ng\u00e0y l\u00e0 30mg (kho\u1ea3ng li\u1ec1u t\u1eeb 10 \u0111\u1ebfn 80mg), v\u00e0 th\u1eddi gian \u0111i\u1ec1u tr\u1ecb trung b\u00ecnh l\u00e0 28 ng\u00e0y (t\u1eeb 1 \u0111\u1ebfn 28 ng\u00e0y). C\u00e1c nghi\u00ean c\u1ee9u n\u00e0y lo\u1ea1i tr\u1eeb c\u00e1c b\u1ec7nh nh\u00e2n b\u1ecb li\u1ec7t d\u1ea1 d\u00e0y do ti\u1ec3u \u0111\u01b0\u1eddng ho\u1eb7c c\u00f3 c\u00e1c tri\u1ec7u ch\u1ee9ng th\u1ee9 ph\u00e1t sau h\u00f3a tr\u1ecb li\u1ec7u ho\u1eb7c b\u1ecb h\u1ed9i ch\u1ee9ng Parkinson.<\/p>\n<p>C\u00e1c thu\u1eadt ng\u1eef v\u00e0 t\u1ea7n su\u1ea5t sau \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng: R\u1ea5t th\u01b0\u1eddng g\u1eb7p (\u2265 1\/10); th\u01b0\u1eddng g\u1eb7p (\u2265 1\/100 \u0111\u1ebfn &lt; 1\/10); \u00edt g\u1eb7p (\u2265 1\/1.000 \u0111\u1ebfn &lt; 1\/100); hi\u1ebfm (\u2265 1\/10.000 \u0111\u1ebfn &lt; 1\/1.000); r\u1ea5t hi\u1ebfm (&lt; 1\/10.000). N\u1ebfu kh\u00f4ng \u01b0\u1edbc t\u00ednh t\u1eeb c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng th\u00ec \u0111\u01b0\u1ee3c coi l\u00e0 \u201cCh\u01b0a r\u00f5\u201d.<\/p>\n<table>\n<tbody>\n<tr>\n<td rowspan=\"2\"><strong>H\u1ec7 th\u1ed1ng c\u01a1 quan<\/strong><\/td>\n<td colspan=\"3\"><strong>T\u1ea7n su\u1ea5t ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>Th\u01b0\u1eddng g\u1eb7p<\/strong><\/td>\n<td><strong>\u00cdt g\u1eb7p<\/strong><\/td>\n<td><strong>Ch\u01b0a r\u00f5<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>R\u1ed1i lo\u1ea1n h\u1ec7 mi\u1ec5n d\u1ecbch<\/strong><\/td>\n<td><\/td>\n<td><\/td>\n<td>Ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn (bao g\u1ed3m s\u1ed1c ph\u1ea3n v\u1ec7)<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"4\"><strong>R\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n<\/strong><\/td>\n<td rowspan=\"4\"><\/td>\n<td>M\u1ea5t ham mu\u1ed1n t\u00ednh d\u1ee5c<\/td>\n<td rowspan=\"4\"><\/td>\n<\/tr>\n<tr>\n<td>Lo l\u1eafng<\/td>\n<\/tr>\n<tr>\n<td>K\u00edch \u0111\u1ed9ng<\/td>\n<\/tr>\n<tr>\n<td>C\u0103ng th\u1eb3ng<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"3\"><strong>R\u1ed1i lo\u1ea1n h\u1ec7 th\u1ea7n kinh<\/strong><\/td>\n<td rowspan=\"3\"><\/td>\n<td>L\u01a1 m\u01a1<\/td>\n<td rowspan=\"3\">Co gi\u1eadt<\/td>\n<\/tr>\n<tr>\n<td>\u0110au \u0111\u1ea7u<\/td>\n<\/tr>\n<tr>\n<td>R\u1ed1i lo\u1ea1n ngo\u1ea1i th\u00e1p<\/td>\n<\/tr>\n<tr>\n<td><strong>R\u1ed1i lo\u1ea1n m\u1eaft<\/strong><\/td>\n<td><\/td>\n<td><\/td>\n<td>C\u01a1n v\u1eadn nh\u00e3n<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"4\"><strong>R\u1ed1i lo\u1ea1n tim m\u1ea1ch (xem C\u1ea3nh b\u00e1o v\u00e0 Th\u1eadn tr\u1ecdng)<\/strong><\/td>\n<td rowspan=\"4\"><\/td>\n<td rowspan=\"4\"><\/td>\n<td>Lo\u1ea1n nh\u1ecbp th\u1ea5t<\/td>\n<\/tr>\n<tr>\n<td>\u0110\u1ed9t t\u1eed do tim<\/td>\n<\/tr>\n<tr>\n<td>K\u00e9o d\u00e0i kho\u1ea3ng QT<\/td>\n<\/tr>\n<tr>\n<td>Xo\u1eafn \u0111\u1ec9nh (xem C\u1ea3nh b\u00e1o v\u00e0 Th\u1eadn tr\u1ecdng)<\/td>\n<\/tr>\n<tr>\n<td><strong>R\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a<\/strong><\/td>\n<td>Kh\u00f4 mi\u1ec7ng<\/td>\n<td>Ti\u00eau ch\u1ea3y<\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td rowspan=\"3\"><strong>R\u1ed1i lo\u1ea1n da v\u00e0 m\u00f4 d\u01b0\u1edbi da<\/strong><\/td>\n<td rowspan=\"3\"><\/td>\n<td>Ph\u00e1t ban<\/td>\n<td rowspan=\"3\">Ph\u00f9 m\u1ea1ch<\/td>\n<\/tr>\n<tr>\n<td>Ng\u1ee9a<\/td>\n<\/tr>\n<tr>\n<td>M\u00e0y \u0111ay<\/td>\n<\/tr>\n<tr>\n<td><strong>R\u1ed1i lo\u1ea1n th\u1eadn v\u00e0 ti\u1ebft ni\u1ec7u<\/strong><\/td>\n<td><\/td>\n<td><\/td>\n<td>B\u00ed ti\u1ec3u<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"3\"><strong>R\u1ed1i lo\u1ea1n h\u1ec7 sinh s\u1ea3n v\u00e0 v\u00fa<\/strong><\/td>\n<td rowspan=\"3\"><\/td>\n<td>Ti\u1ebft s\u1eefa<\/td>\n<td>V\u00fa to \u1edf nam gi\u1edbi<\/td>\n<\/tr>\n<tr>\n<td>\u0110au v\u00fa<\/td>\n<td>M\u1ea5t kinh<\/td>\n<\/tr>\n<tr>\n<td>V\u00fa t\u0103ng nh\u1ea1y c\u1ea3m \u0111au<\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td><strong>R\u1ed1i lo\u1ea1n to\u00e0n th\u00e2n v\u00e0 r\u1ed1i lo\u1ea1n t\u1ea1i n\u01a1i d\u00f9ng thu\u1ed1c<\/strong><\/td>\n<td><\/td>\n<td>Suy nh\u01b0\u1ee3c<\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\"><strong>C\u00e1c ch\u1ec9 s\u1ed1 kh\u00e1c<\/strong><\/td>\n<td rowspan=\"2\"><\/td>\n<td rowspan=\"2\"><\/td>\n<td>K\u1ebft qu\u1ea3 b\u1ea5t th\u01b0\u1eddng trong ki\u1ec3m tra ch\u1ee9c n\u0103ng gan<\/td>\n<\/tr>\n<tr>\n<td>T\u0103ng prolactin m\u00e1u<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Trong 45 th\u1eed nqhi\u1ec7m s\u1eed d\u1ee5ng Domperidon \u1edf m\u1ee9c li\u1ec1u cao h\u01a1n, kho\u1ea3ng th\u1eddi gian \u0111i\u1ec1u tr\u1ecb d\u00e0i h\u01a1n v\u00e0 cho c\u00e1c ch\u1ec9 \u0111\u1ecbnh kh\u00e1c nh\u01b0 li\u1ec7t d\u1ea1 d\u00e0y do ti\u1ec3u \u0111\u01b0\u1eddng, t\u1ea7n su\u1ea5t c\u1ee7a c\u00e1c bi\u1ebfn c\u1ed1 ngo\u1ea1i \u00fd (ngo\u1ea1i tr\u1eeb kh\u00f4 mi\u1ec7ng) l\u00e0 cao h\u01a1n. \u0110i\u1ec1u n\u00e0y l\u00e0 r\u1ea5t r\u00f5 r\u00e0ng \u0111\u1ed1i v\u1edbi c\u00e1c bi\u1ebfn c\u1ed1 d\u01b0\u1ee3c h\u1ecdc c\u00f3 th\u1ec3 d\u1ef1 \u0111o\u00e1n tr\u01b0\u1edbc li\u00ean quan \u0111\u1ebfn t\u0103ng prolactin. Ngo\u00e0i nh\u1eefng ph\u1ea3n \u1ee9ng \u0111\u01b0\u1ee3c li\u1ec7t k\u00ea \u1edf tr\u00ean, b\u1ed3n ch\u1ed3n, ti\u1ebft d\u1ecbch \u1edf v\u00fa, v\u00fa to, c\u0103ng v\u00fa, tr\u1ea7m c\u1ea3m, t\u0103ng m\u1eabn c\u1ea3m, r\u1ed1i lo\u1ea1n ti\u1ebft s\u1eefa, v\u00e0 kinh nguy\u1ec7t kh\u00f4ng \u0111\u1ec1u c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn.<\/p>\n<p>R\u1ed1i lo\u1ea1n ngo\u1ea1i th\u00e1p x\u1ea3y ra ch\u1ee7 y\u1ebfu tr\u00ean tr\u1ebb s\u01a1 sinh v\u00e0 tr\u1ebb nh\u1ecf. C\u00e1c t\u00e1c d\u1ee5ng c\u00f3 li\u00ean quan \u0111\u1ebfn h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng nh\u01b0 co gi\u1eadt v\u00e0 lo \u00e2u c\u0169ng \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o ch\u1ee7 y\u1ebfu \u1edf tr\u1ebb s\u01a1 sinh v\u00e0 tr\u1ebb nh\u1ecf.<\/p>\n<p><em>B\u00e1o c\u00e1o ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i<\/em><\/p>\n<p>B\u00e1o c\u00e1o ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i sau khi thu\u1ed1c \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p l\u01b0u h\u00e0nh r\u1ea5t quan tr\u1ecdng \u0111\u1ec3 ti\u1ebfp t\u1ee5c gi\u00e1m s\u00e1t c\u00e2n b\u1eb1ng l\u1ee3i \u00edch\/ nguy c\u01a1 c\u1ee7a thu\u1ed1c. C\u00e1n b\u1ed9 y t\u1ebf c\u1ea7n b\u00e1o c\u00e1o t\u1ea5t c\u1ea3 ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i v\u1ec1 Trung t\u00e2m Qu\u1ed1c gia ho\u1eb7c Trung t\u00e2m khu v\u1ef1c v\u1ec1 Th\u00f4ng tin thu\u1ed1c v\u00e0 theo d\u00f5i ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c.<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<p><strong>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/strong><\/p>\n<p>Ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c. V\u1edbi c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i nh\u1eb9, th\u01b0\u1eddng ch\u1ec9 c\u1ea7n ng\u1eebng thu\u1ed1c. Tr\u01b0\u1eddng h\u1ee3p m\u1eabn c\u1ea3m n\u1eb7ng ho\u1eb7c ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, c\u1ea7n ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 (gi\u1eef tho\u00e1ng kh\u00ed v\u00e0 d\u00f9ng epinephrin, th\u1edf oxygen, d\u00f9ng kh\u00e1ng histamin, corticoid&#8230;).<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/strong><\/p>\n<p>Khi c\u00e1c thu\u1ed1c kh\u00e1ng acid ho\u1eb7c kh\u00e1ng ti\u1ebft \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi, kh\u00f4ng n\u00ean d\u00f9ng c\u00f9ng l\u00fac v\u1edbi c\u00e1c ch\u1ebf ph\u1ea9m \u0111\u01b0\u1eddng u\u1ed1ng c\u1ee7a Domperidon ,ngh\u0129a l\u00e0 c\u00e1c thu\u1ed1c n\u00e0y n\u00ean d\u00f9ng sau b\u1eefa \u0103n v\u00e0 kh\u00f4ng n\u00ean d\u00f9ng tr\u01b0\u1edbc b\u1eefa \u0103n.<\/p>\n<p>Con \u0111\u01b0\u1eddng chuy\u1ec3n h\u00f3a ch\u00ednh c\u1ee7a Domperidon l\u00e0 qua CYP3A4. C\u00e1c d\u1eef ki\u1ec7n nghi\u00ean c\u1ee9u\u00a0<em>in vitro<\/em>\u00a0cho th\u1ea5y c\u00e1c thu\u1ed1c s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi m\u00e0 g\u00e2y \u1ee9c ch\u1ebf m\u1ea1nh men n\u00e0y c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 Domperidon trong huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<p>T\u0103ng nguy c\u01a1 k\u00e9o d\u00e0i kho\u1ea3ng QT do t\u01b0\u01a1ng t\u00e1c d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc v\u00e0\/ho\u1eb7c d\u01b0\u1ee3c l\u1ef1c h\u1ecdc.<\/p>\n<p><em>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c sau<\/em><\/p>\n<p>C\u00e1c thu\u1ed1c l\u00e0m k\u00e9o d\u00e0i kho\u1ea3ng QT (nguy c\u01a1 xo\u1eafn \u0111\u1ec9nh).<\/p>\n<p>Thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp tim nh\u00f3m IA (v\u00ed d\u1ee5: Disopyramid, Hydroquinidin, Quinidin).<\/p>\n<p>Thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp tim nh\u00f3m III (v\u00ed d\u1ee5: Amiodaron, Dofetilid, Dronedaron, Ibutilid, Sotalol).<\/p>\n<p>M\u1ed9t s\u1ed1 thu\u1ed1c ch\u1ed1ng lo\u1ea1n th\u1ea7n (v\u00ed d\u1ee5: Haloperidol, Pimozid, Sertindol).<\/p>\n<p>M\u1ed9t s\u1ed1 thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m (v\u00ed d\u1ee5: Citalopram, Escitalopram).<\/p>\n<p>M\u1ed9t s\u1ed1 thu\u1ed1c kh\u00e1ng sinh (v\u00ed d\u1ee5: Erythromycin, Levofloxacin, Moxifloxacin, Spiramycin).<\/p>\n<p>M\u1ed9t s\u1ed1 thu\u1ed1c ch\u1ed1ng n\u1ea5m (v\u00ed d\u1ee5: Fluconazol, Pentamidin).<\/p>\n<p>M\u1ed9t s\u1ed1 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb s\u1ed1t r\u00e9t (d\u1eb7c bi\u1ec7t l\u00e0 Halofantrin, Lumefantrin).<\/p>\n<p>M\u1ed9t s\u1ed1 thu\u1ed1c d\u1ea1 d\u00e0y ru\u1ed9t (v\u00ed d\u1ee5: Cisaprid, Dolasetron, Prucaloprid).<\/p>\n<p>M\u1ed9t s\u1ed1 kh\u00e1ng histamin (v\u00ed d\u1ee5: Mequitazin, Mizolastin).<\/p>\n<p>M\u1ed9t s\u1ed1 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb ung th\u01b0 (v\u00ed d\u1ee5: Toremifen, Vandetanib, Vincamin).<\/p>\n<p>M\u1ed9t s\u1ed1 thu\u1ed1c kh\u00e1c (v\u00ed d\u1ee5: Bepridil, Diphemanil, Methadon).<\/p>\n<p>Ch\u1ea5t \u1ee9c ch\u1ebf CYP3A4 m\u1ea1nh (kh\u00f4ng ph\u1ee5 thu\u1ed9c t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i kho\u1ea3ng QT), v\u00ed d\u1ee5:<\/p>\n<p>Thu\u1ed1c \u1ee9c ch\u1ebf protease (v\u00ed d\u1ee5: Ritonavir, Saquinavir, Telaprevir).<\/p>\n<p>Thu\u1ed1c ch\u1ed1ng n\u1ea5m to\u00e0n th\u00e2n nh\u00f3m azol (v\u00ed d\u1ee5: Itraconazol, Ketoconazol, Posaconazol, Voriconazol).<\/p>\n<p>M\u1ed9t s\u1ed1 thu\u1ed1c nh\u00f3m macrolid (Erythromycin, Clarithromycin v\u00e0 Telithromycin).<\/p>\n<p><em>Kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c sau<\/em><\/p>\n<p>Thu\u1ed1c \u1ee9c ch\u1ebf CYP3A4 trung b\u00ecnh, v\u00ed d\u1ee5: Diltiazem, Verapamil v\u00e0 m\u1ed9t s\u1ed1 thu\u1ed1c nh\u00f3m macrolid.<\/p>\n<p><em>S\u1eed d\u1ee5ng th\u1eadn tr\u1ecdng khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c sau<\/em><\/p>\n<p>Thu\u1ed1c ch\u1eadm nh\u1ecbp tim, thu\u1ed1c l\u00e0m gi\u1ea3m kali m\u00e1u v\u00e0 m\u1ed9t s\u1ed1 thu\u1ed1c macrolid sau g\u00f3p ph\u1ea7n l\u00e0m k\u00e9o d\u00e0i kho\u1ea3ng QT: Azithromycin v\u00e0 Roxithromycin (ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh Clathromycin do l\u00e0 thu\u1ed1c \u1ee9c ch\u1ebf CYP3A4 m\u1ea1nh).<\/p>\n<p>Danh s\u00e1ch c\u00e1c ch\u1ea5t \u1edf tr\u00ean l\u00e0 c\u00e1c thu\u1ed1c \u0111\u1ea1i di\u1ec7n v\u00e0 kh\u00f4ng \u0111\u1ea7y \u0111\u1ee7.<\/p>\n<p><strong>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/strong><\/p>\n<p><em>Tri\u1ec7u ch\u1ee9ng<\/em><\/p>\n<p>Qu\u00e1 li\u1ec1u \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o ch\u1ee7 y\u1ebfu \u1edf tr\u1ebb nh\u0169 nhi v\u00e0 tr\u1ebb em. Tri\u1ec7u ch\u1ee9ng qu\u00e1 li\u1ec1u bao g\u1ed3m k\u00edch \u0111\u1ed9ng, r\u1ed1i lo\u1ea1n nh\u1eadn th\u1ee9c, co gi\u1eadt, m\u1ea5t \u0111\u1ecbnh h\u01b0\u1edbng, ng\u1ee7 g\u00e0 v\u00e0 ph\u1ea3n \u1ee9ng ngo\u1ea1i th\u00e1p.<\/p>\n<p><em>\u0110i\u1ec1u tr\u1ecb<\/em><\/p>\n<p>Kh\u00f4ng c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u cho Domperidon. Trong tr\u01b0\u1eddng h\u1ee3p qu\u00e1 li\u1ec1u, c\u1ea7n th\u1ef1c hi\u1ec7n c\u00e1c bi\u1ec7n ph\u00e1p \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng ngay l\u1eadp t\u1ee9c. N\u00ean theo d\u00f5i \u0111i\u1ec7n t\u00e2m \u0111\u1ed3 do kh\u1ea3 n\u0103ng g\u00e2y k\u00e9o d\u00e0i kho\u1ea3ng QT. R\u1eeda d\u1ea1 d\u00e0y c\u0169ng nh\u01b0 d\u00f9ng than ho\u1ea1t c\u00f3 th\u1ec3 h\u1eefu d\u1ee5ng. \u0110\u1ec1 ngh\u1ecb theo d\u00f5i s\u00e1t v\u00e0 \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 cho c\u00e1c b\u1ec7nh nh\u00e2n. C\u00e1c thu\u1ed1c kh\u00e1ng ti\u1ebft cholin ho\u1eb7c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb Parkinson c\u00f3 th\u1ec3 gi\u00fap \u00edch trong vi\u1ec7c ki\u1ec3m so\u00e1t c\u00e1c ph\u1ea3n \u1ee9ng ngo\u1ea1i th\u00e1p.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong> 5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/strong><\/p>\n<p><strong>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/strong><\/p>\n<p>Nh\u00f3m li\u1ec7u ph\u00e1p: t\u0103ng nhu \u0111\u1ed9ng, m\u00e3 ATC: A03FA03<\/p>\n<p>Domperidon l\u00e0 ch\u1ea5t \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 dopamin v\u1edbi \u0111\u1eb7c t\u00ednh ch\u1ed1ng n\u00f4n. Domperidon kh\u00f4ng d\u1ec5 d\u00e0ng qua \u0111\u01b0\u1ee3c h\u00e0ng r\u00e0o m\u00e1u n\u00e3o. \u1ede ng\u01b0\u1eddi s\u1eed d\u1ee5ng Domperidon, \u0111\u1eb7c bi\u1ec7t l\u00e0 ng\u01b0\u1eddi l\u1edbn, t\u00e1c d\u1ee5ng ph\u1ee5 ngo\u1ea1i th\u00e1p r\u1ea5t hi\u1ebfm g\u1eb7p, nh\u01b0ng Domperidon th\u00fac \u0111\u1ea9y s\u1ef1 ti\u1ebft prolactin t\u1ea1i tuy\u1ebfn y\u00ean. T\u00e1c \u0111\u1ed9ng ch\u1ed1ng n\u00f4n c\u00f3 th\u1ec3 do s\u1ef1 ph\u1ed1i h\u1ee3p c\u1ee7a t\u00e1c \u0111\u1ed9ng ngo\u1ea1i bi\u00ean (t\u0103ng v\u1eadn \u0111\u1ed9ng d\u1ea1 d\u00e0y) v\u00e0 vi\u1ec7c kh\u00e1ng th\u1ee5 th\u1ec3 dopamin t\u1ea1i v\u00f9ng c\u1ea3m \u1ee9ng h\u00f3a th\u1ee5 th\u1ec3 CTZ (chemoreceptor trigger zone) n\u1eb1m \u1edf ngo\u00e0i h\u00e0ng r\u00e0o m\u00e1u n\u00e3o \u1edf v\u00f9ng ki\u1ec3m so\u00e1t n\u00f4n c\u1ee7a h\u00e0nh tu\u1ef7. Nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y n\u1ed3ng \u0111\u1ed9 th\u1ea5p trong n\u00e3o, ch\u1ec9 r\u00f5 t\u00e1c d\u1ee5ng c\u1ee7a Domperidon ch\u1ee7 y\u1ebfu tr\u00ean c\u00e1c th\u1ee5 th\u1ec3 dopamin ngo\u1ea1i bi\u00ean.<\/p>\n<p>Nghi\u00ean c\u1ee9u \u1edf ng\u01b0\u1eddi cho th\u1ea5y u\u1ed1ng Domperidon l\u00e0m gia t\u0103ng tr\u01b0\u01a1ng l\u1ef1c \u1edf th\u1ef1c qu\u1ea3n d\u01b0\u1edbi, c\u1ea3i thi\u1ec7n v\u1eadn \u0111\u1ed9ng v\u00f9ng hang v\u1ecb t\u00e1 tr\u00e0ng v\u00e0 th\u00fac \u0111\u1ea9y nhanh qu\u00e1 tr\u00ecnh l\u00e0m r\u1ed7ng d\u1ea1 d\u00e0y. Thu\u1ed1c kh\u00f4ng \u1ea3nh h\u01b0\u1edbng l\u00ean s\u1ef1 ti\u1ebft c\u1ee7a d\u1ea1 d\u00e0y.<\/p>\n<p>Theo h\u01b0\u1edbng d\u1eabn c\u1ee7a ICH-E14, m\u1ed9t nghi\u00ean c\u1ee9u k\u1ef9 l\u01b0\u1ee1ng v\u1ec1 kho\u1ea3ng QT \u0111\u00e3 d\u01b0\u1ee3c th\u1ef1c hi\u1ec7n. Nghi\u00ean c\u1ee9u n\u00e0y l\u00e0 th\u1eed nghi\u1ec7m ki\u1ec3m tr\u1ee9ng khoa h\u1ecdc bao g\u1ed3m thu\u1ed1c so s\u00e1nh c\u00f3 ho\u1ea1t t\u00ednh v\u00e0 gi\u1ea3 d\u01b0\u1ee3c th\u1ef1c hi\u1ec7n tr\u00ean ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh l\u00ean \u0111\u1ebfn 80mg Domperidon m\u1ed9t ng\u00e0y, (10 ho\u1eb7c 20mg 4 l\u1ea7n m\u1ed7i ng\u00e0y). Nghi\u00ean c\u1ee9u n\u00e0y cho th\u1ea5y m\u1ed9t s\u1ef1 kh\u00e1c bi\u1ec7t t\u1ed1i \u0111a v\u1ec1 s\u1ef1 thay \u0111\u1ed5i so v\u1edbi ban \u0111\u1ea7u c\u1ee7a kho\u1ea3ng QT gi\u1eefa Domperidon v\u00e0 gi\u1ea3 d\u01b0\u1ee3c t\u00ednh theo gi\u00e1 tr\u1ecb trung b\u00ecnh b\u00ecnh ph\u01b0\u01a1ng nh\u1ecf nh\u1ea5t l\u00e0 3.4 mili gi\u00e2y cho m\u1ee9c li\u1ec1u 20mg Domperidon 4 l\u1ea7n m\u1ed7i ng\u00e0y t\u1ea1i ng\u00e0y th\u1ee9 4, v\u00e0 kho\u1ea3ng tin c\u1eady 90% hai b\u00ean (1.0 \u0111\u1ebfn 5.9 mili gi\u00e2y) \u0111\u00e3 kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 10 mili gi\u00e2y. Kh\u00f4ng c\u00f3 \u1ea3nh h\u01b0\u1edfng l\u00ean kho\u1ea3ng QT li\u00ean quan v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y trong nghi\u00ean c\u1ee9u n\u00e0y khi m\u00e0 Domperidon \u0111\u01b0\u1ee3c d\u00f9ng l\u00ean \u0111\u1ebfn 80mg\/ng\u00e0y (ngh\u0129a l\u00e0 h\u01a1n 2 l\u1ea7n m\u1ee9c li\u1ec1u t\u1ed1i \u0111a \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o). Tuy nhi\u00ean, 2 nghi\u00ean c\u1ee9u t\u01b0\u01a1ng t\u00e1c thu\u1ed1c thu\u1ed1c tr\u01b0\u1edbc \u0111\u00e2y \u0111\u00e3 ch\u1ec9 ra m\u1ed9t v\u00e0i b\u1eb1ng ch\u1ee9ng k\u00e9o d\u00e0i kho\u1ea3ng QT khi d\u00f9ng Domperidon \u0111\u01a1n tr\u1ecb li\u1ec7u (10mg 4 l\u1ea7n m\u1ed9t ng\u00e0y). S\u1ef1 kh\u00e1c bi\u1ec7t trung b\u00ecnh t\u01b0\u01a1ng \u1ee9ng l\u1edbn nh\u1ea5t v\u1ec1 th\u1eddi gian c\u1ee7a kho\u1ea3ng QTcF gi\u1eefa Domperidon v\u00e0 gi\u1ea3 d\u01b0\u1ee3c t\u01b0\u01a1ng \u1ee9ng l\u00e0 5.4 mili gi\u00e2y (kho\u1ea3ng tin c\u1eady 95%: -1.7 \u0111\u1ebfn 12.4) v\u00e0 7.5 mili gi\u00e2y (kho\u1ea3ng tin c\u1eady 95%: 0.6 \u0111\u1ebfn 14.4).<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>Domperidon l\u00e0 ch\u1ea5t \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 c\u1ea3 th\u1ee5 th\u1ec3 D<sub>1<\/sub> v\u00e0 D<sub>2<\/sub> c\u1ee7a dopamin, t\u01b0\u01a1ng t\u1ef1 nh\u01b0 metoclopramid. Do thu\u1ed1c h\u1ea7u nh\u01b0 kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng l\u00ean c\u00e1c th\u1ee5 th\u1ec3 dopamin \u1edf n\u00e3o n\u00ean domperidon kh\u00f4ng c\u00f3 \u1ea3nh h\u01b0\u1edfng l\u00ean t\u00e2m th\u1ea7n v\u00e0 th\u1ea7n kinh. Domperidon th\u00fac \u0111ay nhu \u0111\u1ed9ng c\u1ee7a d\u1ea1 d\u00e0y (prokinetic agent), l\u00e0m t\u0103ng tr\u01b0\u01a1ng l\u1ef1c c\u01a1 th\u1eaft t\u00e2m v\u1ecb v\u00e0 l\u00e0m t\u0103ng bi\u00ean \u0111\u1ed9 m\u1edf r\u1ed9ng c\u1ee7a c\u01a1 th\u1eaft m\u00f4n v\u1ecb sau b\u1eefa \u0103n, nh\u01b0ng l\u1ea1i kh\u00f4ng \u1ea3nh h\u01b0\u1edfng l\u00ean s\u1ef1 b\u00e0i ti\u1ebft c\u1ee7a d\u1ea1 d\u00e0y. Thu\u1ed1c d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n c\u1ea5p, c\u1ea3 bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n do d\u00f9ng levodopa ho\u1eb7c bromocriptin \u1edf ng\u01b0\u1eddi b\u1ec7nh Parkinson. Tuy nhi\u00ean, do kh\u00f4ng v\u00e0o \u0111\u01b0\u1ee3c th\u1ea7n kinh trung \u01b0\u01a1ng, ch\u1ec9 t\u00e1c d\u1ee5ng \u1edf ngo\u1ea1i bi\u00ean (tr\u00ean v\u00f9ng c\u00f2 s\u00fang, chemoreceptor trigger zone, CTZ \u1edf s\u00e0n n\u00e3o th\u1ea5t 4 v\u00e0 tr\u00ean \u1ed1ng ti\u00eau h\u00f3a) n\u00ean t\u00e1c d\u1ee5ng ch\u1ed1ng n\u00f4n c\u1ee7a domperidon kh\u00f4ng b\u1eb1ng metoclopramid nh\u01b0ng \u00edt g\u00e2y h\u1ed9i ch\u1ee9ng ngo\u1ea1i th\u00e1p h\u01a1n. Domperidon c\u0169ng c\u00f3 kh\u1ea3 n\u0103ng \u0111\u1ed1i kh\u00e1ng l\u1ea1i t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf b\u00e0i ti\u1ebft prolactin g\u00e2y ra b\u1edfi dopamin ho\u1eb7c apomorphin, l\u00e0m t\u0103ng r\u00f5 r\u1ec7t n\u1ed3ng \u0111\u1ed9 prolactin trong huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<p><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/p>\n<p><strong>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/strong><\/p>\n<p><em>H\u1ea5p thu<\/em><\/p>\n<p>Domperidon h\u1ea5p thu nhanh sau khi u\u1ed1ng, v\u1edbi n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t \u0111\u01b0\u1ee3c sau kho\u1ea3ng 1 gi\u1edd. Gi\u00e1 tr\u1ecb C<sub>max<\/sub>\u00a0v\u00e0 AUC c\u1ee7a Domperidon t\u0103ng l\u00ean t\u1ef7 l\u1ec7 v\u1edbi li\u1ec1u trong kho\u1ea3ng li\u1ec1u t\u1eeb 10mg \u0111\u1ebfn 20mg. Quan s\u00e1t th\u1ea5y gi\u00e1 tr\u1ecb AUC c\u1ee7a Domperidon t\u00edch l\u0169y 2 \u0111\u1ebfn 3 l\u1ea7n v\u1edbi li\u1ec1u Domperidon \u0111\u01b0\u1ee3c l\u1eb7p l\u1ea1i 4 l\u1ea7n m\u1ed7i ng\u00e0y (c\u1ee9 m\u1ed7i 5 gi\u1edd) trong 4 ng\u00e0y.<\/p>\n<p>M\u1eb7c d\u00f9 sinh kh\u1ea3 d\u1ee5ng c\u1ee7a Domperidon c\u00f3 gia t\u0103ng \u1edf ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh khi u\u1ed1ng sau b\u1eefa \u0103n, b\u1ec7nh nh\u00e2n c\u00f3 than phi\u1ec1n v\u1ec1 ti\u00eau h\u00f3a n\u00ean u\u1ed1ng Domperidon tr\u01b0\u1edbc khi \u0103n 15 30 ph\u00fat. \u0110\u1ed9 acid trong d\u1ea1 d\u00e0y gi\u1ea3m l\u00e0m gi\u1ea3m s\u1ef1 h\u1ea5p thu Domperidon. Sinh kh\u1ea3 d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng b\u1ecb gi\u1ea3m n\u1ebfu tr\u01b0\u1edbc \u0111\u00f3 b\u1ec7nh nh\u00e2n u\u1ed1ng \u0111\u1ed3ng th\u1eddi cimetidin v\u00e0 natri bicarbonat.<\/p>\n<p><em>Ph\u00e2n b\u1ed1<\/em><\/p>\n<p>T\u1ec9 l\u1ec7 Domperidon g\u1eafn k\u1ebft protein huy\u1ebft t\u01b0\u01a1ng l\u00e0 91 93%. Nghi\u00ean c\u1ee9u s\u1ef1 ph\u00e2n ph\u1ed1i thu\u1ed1c b\u1eb1ng c\u00e1ch \u0111\u00e1nh d\u1ea5u ph\u00f3ng x\u1ea1 tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y thu\u1ed1c \u0111\u01b0\u1ee3c ph\u00e2n b\u1ed1 r\u1ed9ng r\u00e3i trong m\u00f4 c\u01a1 th\u1ec3 nh\u01b0ng n\u1ed3ng \u0111\u1ed9 th\u1ea5p trong n\u00e3o. M\u1ed9t l\u01b0\u1ee3ng nh\u1ecf thu\u1ed1c \u0111i qua nhau thai \u1edf chu\u1ed9t.<\/p>\n<p><em>Chuy\u1ec3n h\u00f3a<\/em><\/p>\n<p>Domperidon tr\u1ea3i qua qu\u00e1 t\u00ecnh chuy\u1ec3n h\u00f3a nhanh v\u00e0 nhi\u1ec1u t\u1ea1i gan b\u1eb1ng s\u1ef1 hydroxyl h\u00f3a v\u00e0 kh\u1eed N-alkyl. C\u00e1c th\u00ed nghi\u1ec7m v\u1ec1 chuy\u1ec3n h\u00f3a tr\u00ean\u00a0<em>in vitro<\/em>\u00a0v\u1edbi c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf bi\u1ebft tr\u01b0\u1edbc cho th\u1ea5y CYP3A4 l\u00e0 m\u1ed9t d\u1ea1ng ch\u00ednh c\u1ee7a cytochrome P-450 li\u00ean quan \u0111\u1ebfn s\u1ef1 kh\u1eed N-alkyl c\u1ee7a Domperidon, trong khi CYP3A4, CYP1A2 v\u00e0 CYP2E1 li\u00ean quan \u0111\u1ebfn s\u1ef1 hydroxyl h\u00f3a nh\u00e2n th\u01a1m c\u1ee7a Domperidon.<\/p>\n<p><em>Th\u1ea3i tr\u1eeb<\/em><\/p>\n<p>Th\u1ea3i tr\u1eeb qua n\u01b0\u1edbc ti\u1ec3u v\u00e0 ph\u00e2n l\u1ea7n l\u01b0\u1ee3t kho\u1ea3ng 31 v\u00e0 66% li\u1ec1u u\u1ed1ng. M\u1ed9t ph\u1ea7n nh\u1ecf thu\u1ed1c \u0111\u01b0\u1ee3c th\u1ea3i ra ngo\u00e0i \u1edf d\u1ea1ng nguy\u00ean v\u1eb9n (10% qua ph\u00e2n v\u00e0 1% qua n\u01b0\u1edbc ti\u1ec3u). Th\u1eddi gian b\u00e1n h\u1ee7y trong huy\u1ebft t\u01b0\u01a1ng sau khi u\u1ed1ng li\u1ec1u \u0111\u01a1n l\u00e0 7 9 gi\u1edd \u1edf ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh nh\u01b0ng k\u00e9o d\u00e0i \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng.<\/p>\n<p><em>Suy gan<\/em><\/p>\n<p>\u1ede b\u1ec7nh nh\u00e2n suy gan m\u1ee9c \u0111\u1ed9 trung b\u00ecnh (ch\u1ec9 s\u1ed1 Pugh t\u1eeb 7 \u0111\u1ebfn 9, \u0111\u1ed9 Child-Pugh B), gi\u00e1 tr\u1ecb AUC v\u00e0 C<sub>max<\/sub>\u00a0c\u1ee7a Domperidon cao h\u01a1n \u1edf ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh l\u1ea7n l\u01b0\u1ee3t l\u00e0 2.9 v\u00e0 1.5 l\u1ea7n. T\u1ec9 l\u1ec7 kh\u00f4ng g\u1eafn k\u1ebft t\u0103ng 25% v\u00e0 th\u1eddi gian b\u00e1n h\u1ee7y k\u00e9o d\u00e0i 15 \u0111\u1ebfn 23 gi\u1edd. Nh\u1eefng b\u1ec7nh nh\u00e2n suy gi\u1ea3m ch\u1ee9c n\u0103ng gan m\u1ee9c \u0111\u1ed9 nh\u1eb9 c\u00f3 n\u1ed3ng \u0111\u1ed9 thu\u1ed1c th\u1ea5p h\u01a1n m\u1ed9t ch\u00fat so v\u1edbi ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh d\u1ef1a tr\u00ean C<sub>max<\/sub>\u00a0v\u00e0 AUC, kh\u00f4ng c\u00f3 s\u1ef1 thay \u0111\u1ed5i v\u1ec1 s\u1ef1 g\u1eafn k\u1ebft v\u1edbi protein hay th\u1eddi gian b\u00e1n h\u1ee7y. Kh\u00f4ng nghi\u00ean c\u1ee9u tr\u00ean c\u00e1c b\u1ec7nh nh\u00e2n suy gan n\u1eb7ng. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh d\u00f9ng Domperidon tr\u00ean b\u1ec7nh nh\u00e2n suy gan trung b\u00ecnh ho\u1eb7c n\u1eb7ng<em>.<\/em><\/p>\n<p><em>Suy th\u1eadn<\/em><\/p>\n<p>\u1ede nh\u1eefng b\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng, \u0111\u1ed9 thanh th\u1ea3i creatinin &lt; 30mL\/min\/1.73m<sup>2<\/sup>, th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a Domperidon t\u0103ng t\u1eeb 7.4 \u0111\u1ebfn 20.8 gi\u1edd nh\u01b0ng n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong huy\u1ebft th\u1ea5p h\u01a1n \u1edf ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n kh\u1ecfe m\u1ea1nh. B\u1edfi v\u00ec m\u1ed9t l\u01b0\u1ee3ng r\u1ea5t nh\u1ecf thu\u1ed1c c\u00f2n nguy\u00ean v\u1eb9n (kho\u1ea3ng 1%) \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua th\u1eadn, n\u00ean c\u00f3 th\u1ec3 kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u khi u\u1ed1ng li\u1ec1u \u0111\u01a1n tr\u00ean b\u1ec7nh nh\u00e2n suy th\u1eadn. Tuy nhi\u00ean, khi d\u00f9ng li\u1ec1u l\u1eadp l\u1ea1i, n\u00ean gi\u1ea3m t\u1ea7n su\u1ea5t li\u1ec1u xu\u1ed1ng c\u00f2n 1 \u0111\u1ebfn 2 l\u1ea7n m\u1ed7i ng\u00e0y t\u00f9y thu\u1ed9c v\u00e0o \u0111\u1ed9 n\u1eb7ng c\u1ee7a suy th\u1eadn v\u00e0 c\u00f3 th\u1ec3 c\u1ea7n gi\u1ea3m li\u1ec1u.<\/p>\n<p><em>B\u1ec7nh nh\u00e2n nhi<\/em><\/p>\n<p>Kh\u00f4ng c\u00f3 d\u1eef li\u1ec7u d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc tr\u00ean b\u1ec7nh nh\u00e2n nhi.<\/p>\n<p><strong>5.3 Gi\u1ea3i th\u00edch: <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong>5.4 Thay th\u1ebf thu\u1ed1c : <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/strong><\/p>\n<p><strong>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/strong><\/p>\n<p>T\u00e1 d\u01b0\u1ee3c: lactose khan, tinh b\u1ed9t b\u1eafp, microcrystallin cellulose, tinh b\u1ed9t ti\u1ec1n gelatin h\u00f3a, povidon K90, magnesium stearat, colloidal Silicon dioxid, polysorbat 20.<\/p>\n<p><strong>6.2. T\u01b0\u01a1ng k\u1ef5 :<\/strong><\/p>\n<p>H\u1ea7u nh\u01b0 kh\u00f4ng c\u00f3 t\u01b0\u01a1ng k\u1ef5 v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c.<\/p>\n<p><strong>6.3. B\u1ea3o qu\u1ea3n: <\/strong><\/p>\n<p>B\u1ea3o qu\u1ea3n thu\u1ed1c trong bao b\u00ec k\u00edn.<\/p>\n<p>H\u1ed7n d\u1ecbch u\u1ed1ng ch\u1ec9 s\u1eed d\u1ee5ng trong v\u00f2ng 3 th\u00e1ng sau khi m\u1edf l\u1ecd thu\u1ed1c.<\/p>\n<p><strong>6.4. Th\u00f4ng tin kh\u00e1c :<\/strong><\/p>\n<p><em>Nghi\u00ean c\u1ee9u ti\u1ec1n l\u00e2m s\u00e0ng<\/em><\/p>\n<p>C\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 \u0111i\u1ec7n sinh l\u00fd h\u1ecdc\u00a0<em>in vitro v\u00e0 in vivo<\/em>\u00a0cho th\u1ea5y m\u1ed9t nguy c\u01a1 trung t\u00ecnh c\u1ee7a Domperidon c\u00f3 th\u1ec3 l\u00e0m k\u00e9o d\u00e0i kho\u1ea3ng QT tr\u00ean ng\u01b0\u1eddi. Trong c\u00e1c th\u1eed nghi\u1ec7m\u00a0<em>in vitro<\/em>\u00a0tr\u00ean c\u00e1c t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c ph\u00e2n l\u1eadp lai t\u1ea1o v\u1edbi gen hERG \u1edf ng\u01b0\u1eddi v\u00e0 tr\u00ean c\u00e1c t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c ph\u00e2n l\u1eadp c\u1ee7a chu\u1ed9t lang, ch\u1ec9 s\u1ed1 ph\u01a1i nhi\u1ec5m dao \u0111\u1ed9ng t\u1eeb 26 47 l\u1ea7n, \u0111\u01b0\u1ee3c d\u1ef1a tr\u00ean c\u00e1c gi\u00e1 tr\u1ecb IC50 \u1ee9c ch\u1ebf qua k\u00eanh ion IKr khi so s\u00e1nh v\u1edbi n\u1ed3ng \u0111\u1ed9 t\u1ef1 do trong huy\u1ebft t\u01b0\u01a1ng \u1edf ng\u01b0\u1eddi sau khi u\u1ed1ng li\u1ec1u t\u1ed1i \u0111a h\u00e0ng ng\u00e0y 10mg 3 l\u1ea7n m\u1ed9t ng\u00e0y. Bi\u00ean \u0111\u1ed9 an to\u00e0n cho vi\u1ec7c k\u00e9o d\u00e0i th\u1eddi gian \u0111i\u1ec7n th\u1ebf ho\u1ea1t \u0111\u1ed9ng trong c\u00e1c th\u1eed nghi\u1ec7m\u00a0<em>in vitro<\/em>\u00a0tr\u00ean c\u00e1c m\u00f4 tim \u0111\u01b0\u1ee3c ph\u00e2n l\u1eadp v\u01b0\u1ee3t qu\u00e1 45 l\u1ea7n n\u1ed3ng \u0111\u1ed9 t\u1ef1 do trong huy\u1ebft t\u01b0\u01a1ng \u1edf ng\u01b0\u1eddi t\u1ea1i m\u1ee9c li\u1ec1u t\u1ed1i \u0111a h\u00e0ng ng\u00e0y (10mg 3 l\u1ea7n m\u1ed7i ng\u00e0y). Bi\u00ean \u0111\u1ed9 an to\u00e0n trong c\u00e1c m\u00f4 h\u00ecnh\u00a0<em>in vitro<\/em>\u00a0v\u1ec1 lo\u1ea1n nh\u1ecbp tim (th\u1eed nghi\u1ec7m ph\u00e2n l\u1eadp m\u00f4 tim b\u1ecb \u1ee9 d\u1ecbch Langendorff) v\u01b0\u1ee3t qu\u00e1 n\u1ed3ng \u0111\u1ed9 t\u1ef1 do trong huy\u1ebft t\u01b0\u01a1ng \u1edf ng\u01b0\u1eddi t\u1ea1i m\u1ee9c li\u1ec1u t\u1ed1i \u0111a h\u00e0ng ng\u00e0y (10mg 3 l\u1ea7n m\u1ed7i ng\u00e0y) t\u1eeb 9 \u0111\u1ebfn 45 l\u1ea7n. Trong c\u00e1c m\u00f4 h\u00ecnh\u00a0<em>in vivo,<\/em>\u00a0kh\u00f4ng c\u00f3 m\u1ee9c \u0111\u1ed9 \u1ea3nh h\u01b0\u1edfng tr\u00ean k\u00e9o d\u00e0i kho\u1ea3ng QT \u1edf ch\u00f3 v\u00e0 lo\u1ea1n nh\u1ecbp tim tr\u00ean th\u1ecf th\u00ed nghi\u1ec7m nh\u1ea1y c\u1ea3m v\u1edbi xo\u1eafn \u0111\u1ec9nh v\u01b0\u1ee3t qu\u00e1 n\u1ed3ng \u0111\u1ed9 t\u1ef1 do trong huy\u1ebft t\u01b0\u01a1ng \u1edf ng\u01b0\u1eddi t\u1ea1i m\u1ee9c li\u1ec1u t\u1ed1i \u0111a h\u00e0ng ng\u00e0y (10mg 3 l\u1ea7n m\u1ed7i ng\u00e0y) l\u1edbn h\u1edbn t\u01b0\u01a1ng \u1ee9ng 22 l\u1ea7n v\u00e0 435 l\u1ea7n. Trong c\u00e1c m\u00f4 h\u00ecnh chu\u1ed9t lang g\u00e2y m\u00ea sau khi truy\u1ec1n t\u0129nh m\u1ea1ch ch\u1eadm, kh\u00f4ng th\u1ea5y c\u00f3 \u1ea3nh h\u01b0\u1edfng l\u00ean kho\u1ea3ng QT t\u1ea1i t\u1ed5ng n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng l\u00e0 45.4ng\/mL m\u00e0 cao h\u01a1n g\u1ea5p 3 l\u1ea7n t\u1ed5ng n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng tr\u00ean \u1edf ng\u01b0\u1eddi t\u1ea1i m\u1ee9c li\u1ec1u t\u1ed1i \u0111a h\u00e0ng ng\u00e0y (10mg 3 l\u1ea7n m\u1ed7i ng\u00e0y). S\u1ef1 t\u01b0\u01a1ng quan v\u1edbi c\u00e1c nghi\u00ean c\u1ee9u sau n\u00e0y tr\u00ean ng\u01b0\u1eddi khi d\u00f9ng Domperidon \u0111\u01b0\u1eddng u\u1ed1ng l\u00e0 kh\u00f4ng ch\u1eafc ch\u1eafn.<\/p>\n<p>Khi c\u00f3 s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a ch\u1ea5t \u1ee9c ch\u1ebf s\u1ef1 chuy\u1ec3n h\u00f3a qua CYP3A4, n\u1ed3ng \u0111\u1ed9 t\u1ef1 do trong huy\u1ebft t\u01b0\u01a1ng c\u1ee7a Domperidon c\u00f3 th\u1ec3 t\u0103ng l\u00ean g\u1ea5p 3 l\u1ea7n. \u1ede m\u1ee9c li\u1ec1u cao, li\u1ec1u g\u00e2y \u0111\u1ed9c cho sinh s\u1ea3n (h\u01a1n 40 l\u1ea7n li\u1ec1u khuy\u1ebfn c\u00e1o d\u00f9ng tr\u00ean ng\u01b0\u1eddi), \u1ea3nh h\u01b0\u1edfng g\u00e2y qu\u00e1i thai \u0111\u00e3 \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y tr\u00ean chu\u1ed9t c\u1ed1ng.<\/p>\n<p>Kh\u00f4ng quan s\u00e1t th\u1ea5y qu\u00e1i thai tr\u00ean chu\u1ed9t th\u01b0\u1eddng v\u00e0 tr\u00ean th\u1ecf.<\/p>\n<p><strong>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/strong><\/p>\n<p>D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n","protected":false},"excerpt":{"rendered":"<p>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Domperidone Ph\u00e2n lo\u1ea1i: Thu\u1ed1c ch\u1ed1ng n\u00f4n nh\u00f3m \u0111\u1ed1i kh\u00e1ng dopamin. Nh\u00f3m ph\u00e1p l\u00fd: Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine) M\u00e3 ATC (Anatomical Therapeutic Chemical): A03FA03. Brand name, MOTILIUM, MOTILIUM-M H\u00e3ng s\u1ea3n xu\u1ea5t : Janssen Pharmaceutica NV 2. D\u1ea1ng b\u00e0o [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":21488,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[370],"tags":[716],"class_list":["post-6880","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc-goc","tag-domperidone"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/6880","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=6880"}],"version-history":[{"count":5,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/6880\/revisions"}],"predecessor-version":[{"id":52213,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/6880\/revisions\/52213"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/21488"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=6880"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=6880"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=6880"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}