{"id":60974,"date":"2024-11-26T22:33:12","date_gmt":"2024-11-26T15:33:12","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=60974"},"modified":"2025-01-07T13:53:07","modified_gmt":"2025-01-07T06:53:07","slug":"bicalutamide-bypro","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/","title":{"rendered":"Bicalutamide &#8211; Bypro"},"content":{"rendered":"<h1><span class=\"ez-toc-section\" id=\"thong-tin-to-huong-dan-su-dung-cua-thuoc-bypro\"><\/span>Th\u00f4ng tin t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng c\u1ee7a thu\u1ed1c Bypro<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><em>Bypro l\u00e0 thu\u1ed1c k\u00ea \u0111\u01a1n nh\u00f3m tr\u1ecb ung th\u01b0 do c\u00f4ng ty Fresenius Kabi Oncology Ltd s\u1ea3n xu\u1ea5t, thu\u1ed1c c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 d\u01b0\u1ee3c ch\u1ea5t Bicalutamide, \u0111\u00e2y l\u00e0 m\u1ed9t ch\u1ea5t kh\u00e1ng androgen. Bypro ng\u0103n ch\u1eb7n ho\u1ea1t \u0111\u1ed9ng c\u1ee7a hormone androgen v\u00e0 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 u\u1ed1ng m\u1ed7i ng\u00e0y ph\u1ed1i h\u1ee3p v\u1edbi m\u1ed9t thu\u1ed1c nh\u00f3m LHRH trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t di c\u0103n giai \u0111o\u1ea1n D2. D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng c\u1ee7a Thu\u1ed1c Bypro (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;):<\/em><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_81 ez-toc-wrap-left counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">N\u1ed9i dung ch\u00ednh<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#thong-tin-to-huong-dan-su-dung-cua-thuoc-bypro\" >Th\u00f4ng tin t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng c\u1ee7a thu\u1ed1c Bypro<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#1-ten-hoat-chat-va-biet-duoc\" >1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#2-dang-bao-che-%e2%80%93-ham-luong\" >2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#3-thong-tin-danh-cho-nguoi-su-dung\" >3. Th\u00f4ng tin d\u00e0nh cho ng\u01b0\u1eddi s\u1eed d\u1ee5ng:<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#31-bypro-la-thuoc-gi\" >3.1. Bypro l\u00e0 thu\u1ed1c g\u00ec?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#32-cau-hoi-thuong-gap-pho-bien\" >3.2. C\u00e2u h\u1ecfi th\u01b0\u1eddng g\u1eb7p ph\u1ed5 bi\u1ebfn:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#4-thong-tin-danh-cho-nhan-vien-y-te\" >4. Th\u00f4ng tin d\u00e0nh cho nh\u00e2n vi\u00ean y t\u1ebf:<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#41-chi-dinh\" >4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#42-lieu-dung-%e2%80%93-cach-dung\" >4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#43-chong-chi-dinh\" >4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#44-than-trong\" >4.4 Th\u1eadn tr\u1ecdng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#45-su-dung-cho-phu-nu-co-thai-va-cho-con-bu\" >4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#46-tac-dung-khong-mong-muon-adr\" >4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#47-huong-dan-cach-xu-tri-adr\" >4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#48-tuong-tac-voi-cac-thuoc-khac\" >4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#49-qua-lieu-va-xu-tri\" >4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#5-co-che-tac-dung-cua-thuoc\" >5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#51-duoc-luc-hoc\" >5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#52-duoc-dong-hoc\" >5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#53-hieu-qua-lam-sang\" >5.3. Hi\u1ec7u qu\u1ea3 l\u00e2m s\u00e0ng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#54-du-lieu-tien-lam-sang\" >5.4. D\u1eef li\u1ec7u ti\u1ec1n l\u00e2m s\u00e0ng:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#6-phan-thong-tin-kem-theo-cua-thuoc\" >6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#61-danh-muc-ta-duoc\" >6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#62-tuong-ky\" >6.2. T\u01b0\u01a1ng k\u1ef5 :<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#63-bao-quan\" >6.3. B\u1ea3o qu\u1ea3n:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#64-thong-tin-khac\" >6.4. Th\u00f4ng tin kh\u00e1c :<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-27\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#65-tai-lieu-tham-khao\" >6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-28\" href=\"https:\/\/pharmog.com\/wp\/bicalutamide-bypro\/#7-nguoi-dang-tai-tac-gia\" >7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n\n<h2><span class=\"ez-toc-section\" id=\"1-ten-hoat-chat-va-biet-duoc\"><\/span><strong>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: <\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <a href=\"https:\/\/pharmog.com\/wp\/bicalutamide\/\">Bicalutamide (Bicalutamid)<\/a><\/strong><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u00f4\u0301c ch\u00f4\u0301ng ung th\u01b0 &gt; Hormon ch\u00f4\u0301ng ung th\u01b0.<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine). Thu\u1ed1c \u0111\u1ed9c.<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): L02BB03.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em><\/strong> <a href=\"https:\/\/pharmog.com\/wp\/bicalutamide-casodex\/\">Casodex<\/a><\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em><\/strong> Bypro<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: Fresenius Kabi Oncology Ltd.<\/p>\n<p><strong><em>H\u00e3ng \u0111\u0103ng k\u00ed<\/em><\/strong>: Fresenius Kabi Deutschland GmbH.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h2><span class=\"ez-toc-section\" id=\"2-dang-bao-che-%e2%80%93-ham-luong\"><\/span><strong>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng: <\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>Vi\u00ean n\u00e9n, m\u1ed7i vi\u00ean: 50 mg.<\/p>\n<p><strong><em>H\u00ecnh \u1ea3nh tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>BYPRO 50<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean n\u00e9n c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Bicalutamide<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>50 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"836\" height=\"473\" class=\"wp-image-60991\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2024\/11\/bypro-bicalutamide-tablets-50mg.png\" alt=\"Bypro (Bicalutamide Tablets 50mg)\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2024\/11\/bypro-bicalutamide-tablets-50mg.png 836w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2024\/11\/bypro-bicalutamide-tablets-50mg-300x170.png 300w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2024\/11\/bypro-bicalutamide-tablets-50mg-768x435.png 768w\" sizes=\"auto, (max-width: 836px) 100vw, 836px\" \/><\/p>\n<h2><span class=\"ez-toc-section\" id=\"3-thong-tin-danh-cho-nguoi-su-dung\"><\/span><strong>3. Th\u00f4ng tin d\u00e0nh cho ng\u01b0\u1eddi s\u1eed d\u1ee5ng:<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"31-bypro-la-thuoc-gi\"><\/span>3.1. Bypro l\u00e0 thu\u1ed1c g\u00ec?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Bypro l\u00e0 thu\u1ed1c k\u00ea \u0111\u01a1n nh\u00f3m tr\u1ecb ung th\u01b0 do c\u00f4ng ty Fresenius Kabi Oncology Ltd s\u1ea3n xu\u1ea5t, thu\u1ed1c c\u00f3 ch\u1ee9a th\u00e0nh ph\u1ea7n ch\u00ednh l\u00e0 d\u01b0\u1ee3c ch\u1ea5t Bicalutamide, \u0111\u00e2y l\u00e0 m\u1ed9t ch\u1ea5t kh\u00e1ng androgen. Bypro ng\u0103n ch\u1eb7n ho\u1ea1t \u0111\u1ed9ng c\u1ee7a hormone androgen v\u00e0 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 u\u1ed1ng m\u1ed7i ng\u00e0y ph\u1ed1i h\u1ee3p v\u1edbi m\u1ed9t thu\u1ed1c nh\u00f3m LHRH trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t di c\u0103n giai \u0111o\u1ea1n D<sub>2.<\/sub><\/p>\n<h3><span class=\"ez-toc-section\" id=\"32-cau-hoi-thuong-gap-pho-bien\"><\/span>3.2. C\u00e2u h\u1ecfi th\u01b0\u1eddng g\u1eb7p ph\u1ed5 bi\u1ebfn:<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><a id=\"post-60974-_Hlk171339962\"><\/a><em>Bicalutamide c\u00f3 ph\u1ea3i l\u00e0 m\u1ed9t ch\u1ea5t ch\u1ee7 v\u1eadn GnRH gi\u1ed1ng leuprolide ho\u1eb7c goserelin kh\u00f4ng?<\/em><\/p>\n<p>Kh\u00f4ng, Bicalutamide thu\u1ed9c nh\u00f3m thu\u1ed1c \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 thu\u1ed1c kh\u00e1ng androgen kh\u00f4ng steroid v\u00e0 th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng c\u00f9ng lo\u1ea1i thu\u1ed1c c\u00f3 c\u1ea5u tr\u00fac t\u01b0\u01a1ng t\u1ef1 LHRH (hay c\u00f2n g\u1ecdi l\u00e0 thu\u1ed1c ch\u1ee7 v\u1eadn hormone gi\u1ea3i ph\u00f3ng gonadotropin (GnRH) nh\u01b0 leuprolide ho\u1eb7c goserelin), ph\u1ed1i h\u1ee3p n\u00e0y \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t.<\/p>\n<p><em>Bicalutamide c\u00f3 n\u1eb1m trong danh m\u1ee5c b\u1ea3o hi\u1ec3m y t\u1ebf \u1edf Vi\u1ec7t Nam kh\u00f4ng?<\/em><\/p>\n<p>Bicalutamide C\u00d3 n\u1eb1m trong danh m\u1ee5c b\u1ea3o hi\u1ec3m y t\u1ebf \u1edf Vi\u1ec7t Nam. Bicalutamide n\u1eb1m trong nh\u00f3m thu\u1ed1c \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00e0 \u0111i\u1ec1u h\u00f2a mi\u1ec5n d\u1ecbch; V\u00ec v\u1eady ng\u01b0\u1eddi b\u1ec7nh c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng thu\u1ed1c n\u00e0y t\u1ea1i c\u00e1c c\u01a1 s\u1edf kh\u00e1m ch\u1eefa b\u1ec7nh theo tuy\u1ebfn b\u1ea3o hi\u1ec3m y t\u1ebf c\u00f3 \u00e1p d\u1ee5ng ph\u00e1c \u0111\u1ed3 n\u00e0y.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"4-thong-tin-danh-cho-nhan-vien-y-te\"><\/span><strong>4. Th\u00f4ng tin d\u00e0nh cho nh\u00e2n vi\u00ean y t\u1ebf: <\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"41-chi-dinh\"><\/span>4.1. Ch\u1ec9 \u0111\u1ecbnh:<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>BYPRO 50 mg u\u1ed1ng m\u1ed7i ng\u00e0y \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng ph\u1ed1i h\u1ee3p v\u1edbi m\u1ed9t thu\u1ed1c nh\u00f3m LHRH trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t di c\u0103n giai \u0111o\u1ea1n D<sub>2<\/sub>.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"42-lieu-dung-%e2%80%93-cach-dung\"><\/span>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p>Thu\u1ed1c \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng. M\u1ed9t l\u1ea7n m\u1ed7i ng\u00e0y (u\u1ed1ng v\u00e0o bu\u1ed5i s\u00e1ng hay bu\u1ed5i t\u1ed1i), k\u00e8m hay kh\u00f4ng k\u00e8m theo th\u1ee9c \u0103n.<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p>Li\u1ec1u khuy\u1ebfn c\u00e1o c\u1ee7a Bicalutamid khi ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c nh\u00f3m LHRH l\u00e0 50 mg, m\u1ed9t l\u1ea7n m\u1ed7i ng\u00e0y (u\u1ed1ng v\u00e0o bu\u1ed5i s\u00e1ng hay bu\u1ed5i t\u1ed1i), k\u00e8m hay kh\u00f4ng k\u00e8m theo th\u1ee9c \u0103n. C\u1ea7n s\u1eed d\u1ee5ng Bicalutamid v\u00e0o c\u00f9ng 1 th\u1eddi \u0111i\u1ec3m \u1edf m\u1ed7i ng\u00e0y. \u0110i\u1ec1u tr\u1ecb b\u1eb1ng Bicalutamid n\u00ean kh\u1edfi \u0111\u1ea7u c\u00f9ng th\u1eddi \u0111i\u1ec3m v\u1edbi c\u00e1c thu\u1ed1c nh\u00f3m LHRH.<\/p>\n<p><em>\u0110i\u1ec1u ch\u1ec9nh li\u1ec1u \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn<\/em><\/p>\n<p>Kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn.<\/p>\n<p><em>\u0110i\u1ec1u ch\u1ec9nh li\u1ec1u \u1edf b\u1ec7nh nh\u00e2n suy gan:<\/em><\/p>\n<p>Kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u \u1edf b\u1ec7nh nh\u00e2n suy gan \u1edf m\u1ee9c \u0111\u1ed9 nh\u1eb9 hay trung b\u00ecnh. M\u1eb7c d\u00f9 th\u1eddi gian b\u00e1n th\u1ea3i t\u0103ng 76% \u1edf b\u1ec7nh nh\u00e2n suy gan n\u1eb7ng, nh\u01b0ng kh\u00f4ng ph\u1ea3i ch\u1ec9nh li\u1ec1u cho c\u1ea3 nh\u00f3m \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"43-chong-chi-dinh\"><\/span>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Qu\u00e1 m\u1eabn: Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng Bicalutamid \u1edf b\u1ec7nh nh\u00e2n c\u00f3 ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn v\u1edbi thu\u1ed1c hay b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c. Ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn bao g\u1ed3m ph\u00f9 m\u1ea1ch, n\u1ed5i m\u1ec1 \u0111ay.<\/p>\n<p>Ph\u1ee5 n\u1eef: Kh\u00f4ng c\u00f3 b\u1ea5t k\u1ef3 ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng bicalutamid n\u00e0o cho ph\u1ee5 n\u1eef v\u00ec th\u1ebf kh\u00f4ng d\u00f9ng cho nh\u00f3m \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y.<\/p>\n<p>Ph\u1ee5 n\u1eef c\u00f3 thai (Xem th\u00eam ph\u1ea7n s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa).<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h3><span class=\"ez-toc-section\" id=\"44-than-trong\"><\/span>4.4 Th\u1eadn tr\u1ecdng:<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Vi\u00eam gan<\/p>\n<p>M\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p hi\u1ebfm hi\u1ebfm g\u00e2y vi\u00eam gan tr\u1ea7m tr\u1ecdng d\u1eabn \u0111\u1ebfn t\u1eed vong ho\u1eb7c ph\u1ea3i nh\u1eadp vi\u1ec7n \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn sau khi thu\u1ed1c l\u01b0u h\u00e0nh. Nh\u1eefng tr\u01b0\u1eddng h\u1ee3p vi\u00eam gan n\u00f3i tr\u00ean th\u01b0\u1eddng x\u1ea3y ra trong 3-4 th\u00e1ng \u0111\u1ea7u ti\u00ean khi s\u1eed d\u1ee5ng bicalutamid. Vi\u00eam gan v\u00e0 t\u0103ng enzym gan cao d\u1eabn \u0111\u1ebfn ng\u01b0ng thu\u1ed1c x\u1ea3y ra v\u1edbi t\u1ef7 l\u1ec7 kho\u1ea3ng 1% b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng bicalutamid trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng.<\/p>\n<p>C\u1ea7n ph\u1ea3i \u0111o transaminase huy\u1ebft thanh tr\u01b0\u1edbc khi tr\u1ecb li\u1ec7u b\u1eb1ng bicalutamid v\u00e0 th\u01b0\u1eddng xuy\u00ean ki\u1ec3m tra trong 4 th\u00e1ng \u0111\u1ea7u ti\u00ean, v\u00e0 sau \u0111\u00f3 l\u00e0 ki\u1ec3m tra theo \u0111\u1ecbnh k\u1ef3. N\u1ebfu c\u00f3 d\u1ea5u hi\u1ec7u hay tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng cho th\u1ea5y c\u00f3 r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng gan (nh\u01b0 bu\u1ed3n n\u00f4n, n\u00f4n m\u1eeda, \u0111au b\u1ee5ng, m\u1ec7t m\u1ecfi, ch\u00e1n \u0103n, tri\u1ec7u ch\u1ee9ng gi\u1ed1ng c\u00fam, n\u01b0\u1edbc ti\u1ec3u s\u1eadm m\u00e0u, v\u00e0ng da, hay m\u1ec1m ph\u1ea7n t\u1eeb b\u1ee5ng ph\u1ea3i tr\u00ean), c\u1ea7n ph\u1ea3i ki\u1ec3m tra ngay transaminase, \u0111\u1eb7c bi\u1ec7t l\u00e0 ALT. N\u1ebfu b\u1ec7nh nh\u00e2n b\u1ecb v\u00e0ng \u0111a v\u00e0o b\u1ea5t k\u1ef3 th\u1eddi \u0111i\u1ec3m n\u00e0o, ho\u1eb7c ALT t\u0103ng tr\u00ean 2 l\u1ea7n gi\u1edbi h\u1ea1n tr\u00ean, c\u1ea7n ph\u1ea3i ng\u01b0ng s\u1eed d\u1ee5ng bicalutamid v\u00e0 theo d\u00f5i ch\u1eb7t ch\u1ebd ch\u1ee9c n\u0103ng th\u1eadn.<\/p>\n<p>Dung n\u1ea1p gluco, \u1edf c\u00e1c b\u1ec7nh nh\u00e2n nam s\u1eed d\u1ee5ng LHRH agonist, c\u00f3 s\u1ef1 gi\u1ea3m dung nap gluco. \u0110i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 bi\u1ec3u hi\u1ec7n b\u1eb1ng \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng hay m\u1ea5t ki\u1ec3m so\u00e1t gluco huy\u1ebft \u1edf b\u1ec7nh nh\u00e2n b\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng.<\/p>\n<p>V\u00ec th\u1ebf c\u1ea7n ki\u1ec3m so\u00e1t gluco huy\u1ebft \u1edf b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh s\u1eed: d\u1ee5ng bicalutamid ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c LHRH agonist.<\/p>\n<p>C\u00e1c x\u00e9t nghi\u1ec7m th\u01b0\u1eddng xuy\u00ean \u0111\u00e1nh gi\u00e1 ch\u1ec9 s\u1ed1 PSA huy\u1ebft thanh nh\u1eb1m theo d\u00f5i \u0111\u00e1p \u1ee9ng c\u1ee7a b\u1ec7nh nh\u00e2n. N\u1ebfu h\u00e0m l\u01b0\u1ee3ng PSA t\u0103ng trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb b\u1eb1ng bicalutamid, c\u1ea7n ph\u1ea3i \u0111\u00e1nh gi\u00e1 b\u1ec7nh nh\u00e2n v\u1ec1 s\u1ef1 ti\u1ebfn tri\u1ec3n l\u00e2m s\u00e0ng. \u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n c\u00f3 b\u1ec7nh ti\u1ebfn tri\u1ec3n kh\u00e1ch quan k\u00e8m theo s\u1ef1 gia t\u0103ng PSA, c\u1ea7n ph\u1ea3i c\u00e2n nh\u1eafc vi\u1ec7c ng\u01b0ng s\u1eed d\u1ee5ng m\u1ed9t th\u1eddi gian thu\u1ed1c kh\u00e1ng androgen trong khi v\u1eabn ti\u1ebfp t\u1ee5c s\u1eed d\u1ee5ng LHRH.<\/p>\n<p><em>Tr\u1ebb em<\/em>: Ch\u01b0a x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a bicalutamid tr\u00ean tr\u1ebb em.<\/p>\n<p><em>Ng\u01b0\u1eddi cao tu\u1ed5i:<\/em> Trong 2 nghi\u00ean c\u1ee9u \u1edf c\u00e1c b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng li\u1ec1u 50 hay 150 mg m\u1ed7i ng\u00e0y, kh\u00f4ng c\u00f3 m\u1ed1i li\u00ean quan gi\u1eefa tu\u1ed5i v\u00e0 n\u1ed3ng \u0111\u1ed9 thu\u1ed1c \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh trong huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<p><em>Suy gan:<\/em> C\u1ea7n th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng bicalutamid \u1edf b\u1ec7nh nh\u00e2n suy gan t\u1eeb nh\u1eb9 \u0111\u1ebfn n\u1eb7ng. Bicalutamid chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu \u1edf gan. M\u1ed9t v\u00e0i d\u1eef li\u1ec7u tr\u00ean b\u1ec7nh nh\u00e2n suy gan n\u1eb7ng cho th\u1ea5y s\u1ef1 \u0111\u00e0o th\u1ea3i c\u1ee7a bicalutamid b\u1ecb k\u00e9o d\u00e0i v\u00e0 c\u00f3 th\u1ec3 g\u00e2y t\u00edch l\u0169y thu\u1ed1c \u1edf b\u1ec7nh nh\u00e2n suy gan. C\u1ea7n ph\u1ea3i th\u01b0\u1eddng xuy\u00ean ki\u1ec3m tra ch\u1ee9c n\u0103ng gan khi \u0111i\u1ec1u tr\u1ecb d\u00e0i h\u1ea1n.<\/p>\n<p>Kh\u00f4ng c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng v\u1ec1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a b\u1ea5t k\u1ef3 d\u1ea1ng \u0111\u1ed3ng ph\u00e2n n\u00e0o c\u1ee7a bicalutamid \u1edf b\u1ec7nh nh\u00e2n suy gan t\u1eeb nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh khi so s\u00e1nh v\u1edbi \u0111\u1ed1i t\u01b0\u1ee3ng kh\u1ecfe m\u1ea1nh. Tuy nhi\u00ean th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a d\u1ea1ng \u0111\u1ed3ng ph\u00e2n R t\u0103ng kho\u1ea3ng 76% \u1edf b\u1ec7nh nh\u00e2n suy gan n\u1eb7ng (5,8 ng\u00e0y \u1edf b\u1ec7nh nh\u1eadn c\u00f3 ch\u1ee9c n\u0103ng gan b\u00ecnh th\u01b0\u1eddng v\u00e0 10,4 ng\u00e0y \u1edf b\u1ec7nh nh\u00e2n suy gan n\u1eb7ng) (n=4)<\/p>\n<p><em>Suy th\u1eadn:<\/em><\/p>\n<p>Suy th\u1eadn (\u0111\u00e1nh gi\u00e1 b\u1eb1ng \u0111\u1ed9 thanh th\u1ea3i creatinine) kh\u00f4ng c\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 \u0111\u00e0o th\u1ea3i t\u1ed5ng l\u01b0\u1ee3ng bicalutamid hay \u0111\u1ed3ng ph\u00e2n d\u1ea1ng R.<\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>D\u00f9ng bicalutamid kh\u00f4ng l\u00e0m \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c. Tuy nhi\u00ean b\u1ec7nh nh\u00e2n c\u1ea7n l\u01b0u \u00fd v\u00e0 th\u1eadn tr\u1ecdng v\u00ec \u0111\u00f4i khi c\u00f3 c\u1ea3m gi\u00e1c bu\u1ed3n ng\u1ee7.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"45-su-dung-cho-phu-nu-co-thai-va-cho-con-bu\"><\/span>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: D<\/p>\n<p>US FDA pregnancy category: X<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>Kh\u00f4ng c\u00f3 b\u1ea5t k\u1ef3 ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng bicalutamid n\u00e0o cho ph\u1ee5 n\u1eef v\u00ec th\u1ebf kh\u00f4ng d\u00f9ng cho nh\u00f3m \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y.<\/p>\n<p>Bicalutamid c\u00f3 th\u1ec3 g\u00e2y \u0111\u1ed9c t\u00ednh tr\u00ean ph\u00f4i thai khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng bicalutamid \u1edf ph\u1ee5 n\u1eef c\u00f3 thai ho\u1eb7c s\u1eafp c\u00f3 thai. Ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u n\u00e0o v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng bicalutamid \u1edf ph\u1ee5 n\u1eef c\u00f3 thai. N\u1ebfu thu\u1ed1c n\u00e0y \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong su\u1ed1t th\u1eddi k\u1ef3 mang thai ho\u1eb7c n\u1ebfu b\u1ec7nh nh\u00e2n c\u00f3 thai khi s\u1eed d\u1ee5ng thu\u1ed1c, c\u1ea7n ph\u1ea3i th\u00f4ng b\u00e1o cho b\u1ec7nh nh\u00e2n c\u00e1c nguy c\u01a1 tr\u00ean ph\u00f4i thai.<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>Kh\u00f4ng c\u00f3 b\u1ea5t k\u1ef3 ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng bicalutamid n\u00e0o cho ph\u1ee5 n\u1eef v\u00ec th\u1ebf kh\u00f4ng d\u00f9ng cho nh\u00f3m \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h3><span class=\"ez-toc-section\" id=\"46-tac-dung-khong-mong-muon-adr\"><\/span>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Do c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh d\u01b0\u1edbi nh\u1eefng \u0111i\u1ec1u ki\u1ec7n r\u1ea5t kh\u00e1c nhau, v\u00ec th\u1ebf t\u1ef7 l\u1ec7 xu\u1ea5t hi\u1ec7n c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i c\u1ee7a m\u1ed9t thu\u1ed1c kh\u00f4ng th\u1ec3 so s\u00e1nh tr\u1ef1c ti\u1ebfp v\u1edbi t\u1ef7 l\u1ec7 xu\u1ea5t hi\u1ec7n ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i khi th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng c\u1ee7a thu\u1ed1c kh\u00e1c v\u00e0 c\u00f3 th\u1ec3 kh\u00f4ng ph\u1ea3n \u00e1nh \u0111\u01b0\u1ee3c t\u1ef7 l\u1ec7 x\u1ea3y ra tr\u00ean th\u1ef1c t\u1ebf.<\/p>\n<p><em>Kinh nghi\u1ec7m th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng<\/em><\/p>\n<p>Do c\u00e1c b\u1ec7nh nh\u00e2n ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t ti\u1ec1n tri\u1ec3n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng bicalutamid ph\u1ed1i h\u1ee3p v\u1edbi m\u1ed9t thu\u1ed1c nh\u00f3m LHRH, ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i th\u01b0\u1eddng x\u1ea3y ra nh\u1ea5t l\u00e0 \u0111\u1ecf b\u1eebng m\u1eb7t (63%)<\/p>\n<p>Trong 1 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u0111a trung t\u00e2m, m\u00f9 \u0111\u00f4i, c\u00f3 \u0111\u1ed1i ch\u1ee9ng, so s\u00e1nh bicalutamid 80 mg u\u1ed1ng m\u1ed7i ng\u00e0y v\u1edbi flutamid 250 mg u\u1ed1ng 3 l\u1ea7n m\u1ed7i ng\u00e0y, v\u00e0 c\u1ea3 2 \u0111\u1ec1u \u0111\u01b0\u1ee3c k\u1ebft h\u1ee3p v\u1edbi m\u1ed9t thu\u1ed1c nh\u00f3m LHRH, nh\u1eefng ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i trong b\u1ea3ng d\u01b0\u1edbi \u0111\u00e2y x\u1ea3y ra v\u1edbi t\u1ef7 l\u1ec7 t\u1ed1i thi\u1ec3u l\u00e0 5%, b\u1ea5t k\u1ec3 nguy\u00ean nh\u00e2n.<\/p>\n<p>B\u1ea3ng 2: T\u1ea7n su\u1ea5t c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i (&gt; 5% trong m\u1ed7i nh\u00f3m tr\u1ecb li\u1ec7u) b\u1ea5t k\u1ec3 nguy\u00ean nh\u00e2n<\/p>\n<table>\n<tbody>\n<tr>\n<td rowspan=\"2\"><strong>Ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i theo h\u1ec7 c\u01a1 quan<\/strong><\/td>\n<td colspan=\"2\"><strong>Nh\u00f3m \u0111i\u1ec1u tr\u1ecb s\u1ed1 b\u1ec7nh nh\u00e2n (t\u1ef7 l\u1ec7 %)<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>CASODEX + LHRH <\/strong><\/p>\n<p><strong>(n = 401)<\/strong><\/td>\n<td><strong>F1utamid + LHRH <\/strong><\/p>\n<p><strong>(n = 407)<\/strong><\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\"><strong>To\u00e0n b\u1ed9 c\u01a1 th\u1ec3<\/strong><\/td>\n<\/tr>\n<tr>\n<td>\u0110au (t\u1ed5nq qu\u00e1t)<\/td>\n<td>142 (35)<\/td>\n<td>127 (31)<\/td>\n<\/tr>\n<tr>\n<td>\u0110au l\u01b0ng<\/td>\n<td>102 (25)<\/td>\n<td>105 (26)<\/td>\n<\/tr>\n<tr>\n<td>Suy nh\u01b0\u1ee3c<\/td>\n<td>89 (22)<\/td>\n<td>87 (21)<\/td>\n<\/tr>\n<tr>\n<td>\u0110au v\u00f9ng ch\u1eadu<\/td>\n<td>85(21)<\/td>\n<td>70(17)<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m tr\u00f9ng<\/td>\n<td>71 (18)<\/td>\n<td>57 (14)<\/td>\n<\/tr>\n<tr>\n<td>\u0110au b\u1ee5ng<\/td>\n<td>46 (11)<\/td>\n<td>46(11)<\/td>\n<\/tr>\n<tr>\n<td>\u0110au ng\u1ef1c<\/td>\n<td>34 (8)<\/td>\n<td>34(8}<\/td>\n<\/tr>\n<tr>\n<td>\u0110au \u0111\u1ea7u<\/td>\n<td>29(7)<\/td>\n<td>27 (7\u1eca__<\/td>\n<\/tr>\n<tr>\n<td>H\u1ed9i ch\u1ee9ng c\u00fam<\/td>\n<td>28 (7)<\/td>\n<td>30 (7)<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\"><strong>Tim-m\u1ea1ch\u00a0\u00a0<\/strong><\/td>\n<\/tr>\n<tr>\n<td>\u0110\u1ecf b\u1eebng m\u1eb7t<\/td>\n<td>211 (53)<\/td>\n<td>217 (53)<\/td>\n<\/tr>\n<tr>\n<td>T\u0103ng huy\u1ebft \u00e1p<\/td>\n<td>34 (8)<\/td>\n<td>29 (7)<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\"><strong>Ti\u00eau h\u00f3a<\/strong><\/td>\n<\/tr>\n<tr>\n<td>T\u00e1o b\u00f3n<\/td>\n<td>87 (22)<\/td>\n<td>69 (17)<\/td>\n<\/tr>\n<tr>\n<td>Bu\u1ed3n n\u00f4n<\/td>\n<td>62 (15)<\/td>\n<td>58 (14)<\/td>\n<\/tr>\n<tr>\n<td>Ti\u00eau ch\u1ea3y<\/td>\n<td>49 (12)<\/td>\n<td>107 (26)<\/td>\n<\/tr>\n<tr>\n<td>T\u0103nq enzym gan<\/td>\n<td>30 (7)<\/td>\n<td>46 (11)<\/td>\n<\/tr>\n<tr>\n<td>R\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a<\/td>\n<td>30 (7)<\/td>\n<td>23 (6)<\/td>\n<\/tr>\n<tr>\n<td>\u0110\u1ea7y h\u01a1i<\/td>\n<td>26 (6)<\/td>\n<td>22 (5)<\/td>\n<\/tr>\n<tr>\n<td>M\u1ec7t m\u1ecfi<\/td>\n<td>25 (6)<\/td>\n<td>29 (7)<\/td>\n<\/tr>\n<tr>\n<td>N\u00f4n m\u1eeda<\/td>\n<td>24(6)<\/td>\n<td>32 (8)<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\"><strong>Mi\u1ec5n d\u1ecbch v\u00e0 b\u1ea1ch huy\u1ebft<\/strong><\/td>\n<\/tr>\n<tr>\n<td>Thi\u1ebfu m\u00e1u<\/td>\n<td>\u00a045 (11)<\/td>\n<td>53(13)<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\"><strong>Chuy\u1ec3n h\u00f3a v\u00e0 dinh d\u01b0\u1ee1ng<\/strong><\/td>\n<\/tr>\n<tr>\n<td>Ph\u00f9 ngo\u1ea1i bi\u00ean<\/td>\n<td>53 (13)<\/td>\n<td>42 (10)<\/td>\n<\/tr>\n<tr>\n<td>S\u1ee5t c\u00e2n<\/td>\n<td>30 (7)<\/td>\n<td>39 (10)<\/td>\n<\/tr>\n<tr>\n<td>T\u0103ng gluco huy\u1ebft<\/td>\n<td>26 (6)<\/td>\n<td>27 (7)<\/td>\n<\/tr>\n<tr>\n<td>T\u1ea3ng Alkaline Phcsphatase<\/td>\n<td>22 (5)<\/td>\n<td>24 (6)<\/td>\n<\/tr>\n<tr>\n<td>T\u0103ng c\u00e2n<\/td>\n<td>22(5)<\/td>\n<td>18(4)<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\"><strong>C\u01a1-x\u01b0\u01a1ng<\/strong><\/td>\n<\/tr>\n<tr>\n<td>\u0110au x\u01b0\u01a1ng<\/td>\n<td>37 (9)<\/td>\n<td>43 (11)<\/td>\n<\/tr>\n<tr>\n<td>Nh\u01b0\u1ee3c c\u01a1<\/td>\n<td>27 (7)<\/td>\n<td>19 (5)<\/td>\n<\/tr>\n<tr>\n<td>\u0110au kh\u1edbp<\/td>\n<td>21 (5)<\/td>\n<td>29 (7)<\/td>\n<\/tr>\n<tr>\n<td>G\u00e3y x\u01b0\u01a1ng b\u1ec7nh l\u00fd<\/td>\n<td>17(4)<\/td>\n<td>32 (8)<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\"><strong>H\u1ec7 th\u1ea7n kinh<\/strong><\/td>\n<\/tr>\n<tr>\n<td>Ch\u00f3ng m\u1eb7t<\/td>\n<td>41 (10)<\/td>\n<td>35 (9)<\/td>\n<\/tr>\n<tr>\n<td>D\u1ecb c\u1ea3m<\/td>\n<td>31 (8)<\/td>\n<td>40(10)<\/td>\n<\/tr>\n<tr>\n<td>M\u1ea5t ng\u1ee7<\/td>\n<td>27 (7)<\/td>\n<td>39(10)<\/td>\n<\/tr>\n<tr>\n<td>Lo \u00e2u<\/td>\n<td>20 (5)<\/td>\n<td>9(2)<\/td>\n<\/tr>\n<tr>\n<td>Tr\u1ea7m c\u1ea3m<\/td>\n<td>16(4)<\/td>\n<td>33(8)<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\"><strong>H\u1ec7 h\u00f4 h\u1ea5p<\/strong><\/td>\n<\/tr>\n<tr>\n<td>R\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a<\/td>\n<td>51 (13)<\/td>\n<td>32 (8)<\/td>\n<\/tr>\n<tr>\n<td>Ho gia t\u0103ng<\/td>\n<td>33 (8)<\/td>\n<td>24 (6)<\/td>\n<\/tr>\n<tr>\n<td>Vi\u00eam h\u1ea7u<\/td>\n<td>32 (8)<\/td>\n<td>23 (6)<\/td>\n<\/tr>\n<tr>\n<td>Vi\u00eam ph\u1ebf qu\u1ea3n<\/td>\n<td>24 (6)<\/td>\n<td>22 (3)<\/td>\n<\/tr>\n<tr>\n<td>Vi\u00eam ph\u1ed5i<\/td>\n<td>18(4)<\/td>\n<td>19(5)<\/td>\n<\/tr>\n<tr>\n<td>Vi\u00eam m\u0169i<\/td>\n<td>15(4)<\/td>\n<td>22(5)<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\"><strong>Da v\u00e0 ph\u1ea7n ph\u1ee5<\/strong><\/td>\n<\/tr>\n<tr>\n<td>N\u1ed5i m\u1ea9n<\/td>\n<td>35 (9)<\/td>\n<td>30 (7)<\/td>\n<\/tr>\n<tr>\n<td>\u0110\u1ed5 m\u1ed3 h\u00f4i<\/td>\n<td>25(6)<\/td>\n<td>20(5)<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\"><strong>Ti\u1ebft ni\u1ec7u-sinh d\u1ee5c<\/strong><\/td>\n<\/tr>\n<tr>\n<td>Ti\u1ec3u \u0111\u00eam<\/td>\n<td>49(12)<\/td>\n<td>55 (14)<\/td>\n<\/tr>\n<tr>\n<td>Ti\u1ec3u ra m\u00e1u<\/td>\n<td>48(12)<\/td>\n<td>26 (6)<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng ti\u1ec3u<\/td>\n<td>35 (9)<\/td>\n<td>36 (9)<\/td>\n<\/tr>\n<tr>\n<td>Ch\u1ea3y s\u1eefa<\/td>\n<td>36 (9)<\/td>\n<td>30 (7)<\/td>\n<\/tr>\n<tr>\n<td>B\u1ea5t l\u1ef1c<\/td>\n<td>27 (7)<\/td>\n<td>35 (9)<\/td>\n<\/tr>\n<tr>\n<td>\u0110au v\u00fa<\/td>\n<td>23 (6)<\/td>\n<td>15(4)<\/td>\n<\/tr>\n<tr>\n<td>Ti\u1ec3u nhi\u1ec1u l\u1ea7n<\/td>\n<td>23 (6)<\/td>\n<td>29 (7)<\/td>\n<\/tr>\n<tr>\n<td>L\u01b0u gi\u1eef n\u01b0\u1edbc ti\u1ec3u<\/td>\n<td>20 (5)<\/td>\n<td>14(3)<\/td>\n<\/tr>\n<tr>\n<td>R\u1ed1i lo\u1ea1n ti\u1ec3u ti\u1ec7n<\/td>\n<td>19(5)<\/td>\n<td>15(4)<\/td>\n<\/tr>\n<tr>\n<td>Ti\u1ec3u m\u1ea5t ki\u1ec3m so\u00e1t<\/td>\n<td>1114)<\/td>\n<td>32 (8)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>C\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i kh\u00e1c (v\u1edbi t\u1ef7 l\u1ec7 &gt;2%, nh\u01b0ng &lt;5%) \u0111\u01b0\u1ee3c ghi nh\u1eadn trong nh\u00f3m s\u1eed d\u1ee5ng bicalutamid-LHRH nh\u01b0 sau v\u1edbi t\u1ea7n su\u1ea5t gi\u1ea3m d\u1ea7n v\u00e0 kh\u00f4ng k\u1ec3 nguy\u00ean nh\u00e2n.<\/p>\n<p><em>To\u00e0n b\u1ed9 c\u01a1 th\u1ec3:<\/em> g\u00e2y m\u00f4 t\u00e2n sinh, \u0111au c\u1ed5, s\u1ed1t, \u1edbn l\u1ea1nh, nhi\u1ec5m tr\u00f9ng m\u00e1u, tho\u00e1t v\u1ecb, t\u1ea1o nang.<\/p>\n<p><em>Tim-m\u1ea1ch:<\/em> g\u00e2y \u0111au th\u1eaft ng\u1ef1c, suy tim sung huy\u1ebft, nh\u1ed3i m\u00e1u c\u01a1 tim, ng\u01b0ng tim, r\u1ed1i lo\u1ea1n m\u1ea1ch v\u00e0nh, ng\u1ea5t.<\/p>\n<p><em>Ti\u00eau h\u00f3a<\/em>: ph\u00e2n \u0111en, xu\u1ea5t huy\u1ebft tr\u1ef1c tr\u00e0ng, kh\u00f4 mi\u1ec7ng, nu\u1ed1t kh\u00f3, r\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a, \u00e1p-xe quanh r\u0103ng, ung th\u01b0 \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/p>\n<p><em>Chuy\u1ec3n h\u00f3a v\u00e0 dinh d\u01b0\u1ee1ng:<\/em> ph\u00f9, t\u0103ng ch\u1ec9 s\u1ed1 BUN v\u00e0 creatinin, m\u1ea5t n\u01b0\u1edbc, Gout, t\u0103ng cholesterol huy\u1ebft.<\/p>\n<p><em>C\u01a1-x\u01b0\u01a1ng:<\/em> \u0111au c\u01a1, co c\u1ee9ng ch\u00e2n.<\/p>\n<p><em>Th\u1ea7n kinh<\/em>: t\u0103ng tr\u01b0\u01a1ng l\u1ef1c, nh\u1ea7m l\u1eabn, l\u01a1 m\u01a1, gi\u1ea3m t\u00ecnh d\u1ee5c, b\u1ec7nh th\u1ea7n kinh, c\u0103ng th\u1eb3ng.<\/p>\n<p><em>H\u00f4 h\u1ea5p:<\/em> r\u1ed1i lo\u1ea1n ph\u1ed5i, hen suy\u1ec5n, ch\u1ea3y m\u00e1u cam, vi\u00eam xoang.<\/p>\n<p><em>Da v\u00e0 ph\u1ea7n ph\u1ee5:<\/em> kh\u00f4 da, r\u1ee5ng t\u00f3c, ng\u1ee9a, nhi\u1ec5m Herpes zoster, ung th\u01b0 da, r\u1ed1i lo\u1ea1n da.<\/p>\n<p><em>Gi\u00e1c quan:<\/em> c\u01b0\u1eddm m\u1eaft.<\/p>\n<p><em>Ti\u1ebft ni\u1ec7u-sinh d\u1ee5c<\/em>: r\u1ed1i lo\u1ea1n ti\u1ebft ni\u1ec7u, mu\u1ed1n ti\u1ec3u ngay, gi\u00e3n th\u1eadn, r\u1ed1i lo\u1ea1n \u0111\u01b0\u1eddng ti\u1ec3u.<\/p>\n<p><em>B\u1ea5t th\u01b0\u1eddng v\u1ec1 x\u00e9t nghi\u1ec7m<\/em>: T\u0103ng AST, ALT, bilirubin, BUN v\u00e0 creatinin v\u00e0 gi\u1ea3m hemoglobin, s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u \u0111\u1ec1u \u0111\u01b0\u1ee3c ghi nh\u1eadn tr\u00ean c\u1ea3 2 nh\u00f3m \u0111i\u1ec1u tr\u1ecb b\u1eb1ng bicalutamid-LHRH v\u00e0 flutamide-LHRH.<\/p>\n<p><strong><em>C\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i x\u1ea3y ra sau khi l\u01b0u h\u00e0nh thu\u1ed1c:<\/em><\/strong><\/p>\n<p>M\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p hi\u1ebfm g\u00e2y vi\u00eam ph\u1ed5i m\u00f4 k\u1ebb v\u00e0 x\u01a1 ph\u1ed5i \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn khi s\u1eed d\u1ee5ng bicalutamid.<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<h3><span class=\"ez-toc-section\" id=\"47-huong-dan-cach-xu-tri-adr\"><\/span>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c. V\u1edbi c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i nh\u1eb9, th\u01b0\u1eddng ch\u1ec9 c\u1ea7n ng\u1eebng thu\u1ed1c. Tr\u01b0\u1eddng h\u1ee3p m\u1eabn c\u1ea3m n\u1eb7ng ho\u1eb7c ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, c\u1ea7n ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 (gi\u1eef tho\u00e1ng kh\u00ed v\u00e0 d\u00f9ng epinephrin, th\u1edf oxygen, d\u00f9ng kh\u00e1ng histamin, corticoid&#8230;).<\/p>\n<h3><span class=\"ez-toc-section\" id=\"48-tuong-tac-voi-cac-thuoc-khac\"><\/span>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>C\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng cho th\u1ea5y kh\u00f4ng c\u00f3 s\u1ef1 t\u01b0\u01a1ng t\u00e1c n\u00e0o gi\u1eefa bicalutamid v\u00e0 c\u00e1c thu\u1ed1c nh\u00f3m LHRH (goserelin hay leuprolide). Kh\u00f4ng c\u00f3 b\u1eb1ng ch\u1ee9ng cho th\u1ea5y bicalutamid g\u00e2y c\u1ea3m \u1ee9ng enzym gan.<\/p>\n<p>C\u00e1c nghi\u00ean c\u1ee9u in vitro cho th\u1ea5y r\u1eb1ng R-bicalutamid l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf CYP 3A4 v\u00e0 c\u00f3 t\u00e1c \u0111\u1ed9ng \u1ee9c ch\u1ebf tr\u00ean CYP 2C9, 2C19 v\u00e0 2D6 \u1edf m\u1ee9c \u0111\u1ed9 th\u1ea5p h\u01a1n. C\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng cho th\u1ea5y khi s\u1eed d\u1ee5ng chung v\u1edbi bicalutamid, n\u1ed3ng \u0111\u1ed9 trung b\u00ecnh c\u1ee7a midazolam (1 c\u01a1 ch\u1ea5t c\u1ee7a CYP 3A4) t\u0103ng kho\u1ea3ng 1,5 l\u1ea7n (tr\u00ean C<sub>max<\/sub>) v\u00e0 1,9 l\u1ea7n (tr\u00ean AUC). V\u00ec th\u1ebf c\u1ea7n th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng bicalutamid v\u1edbi c\u00e1c thu\u1ed1c l\u00e0 c\u01a1 ch\u1ea5t c\u1ee7a CYP3A4.<\/p>\n<p>Nh\u1eefng nghi\u00ean c\u1ee9u in vitro v\u1ec1 s\u1ef1 g\u1eafn k\u1ebft v\u1edbi protein cho th\u1ea5y r\u1eb1ng bicalutamid c\u00f3 th\u1ec3 thay th\u1ebf thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng lo\u1ea1i coumarin tr\u00ean v\u1ecb tr\u00ed g\u1eafn v\u1edbi protein. V\u00ec th\u1ebf c\u1ea7n theo d\u00f5i th\u1eddi gian prothrombin \u1edf c\u00e1c b\u1ec7nh nh\u00e2n \u0111\u00e3 s\u1eed d\u1ee5ng thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng lo\u1ea1i coumarin v\u00e0 b\u1eaft \u0111\u1ea7u s\u1eed d\u1ee5ng bioalutamid, v\u00e0 l\u00fac n\u00e0y c\u1ea7n ph\u1ea3i \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng.<\/p>\n<p>Kh\u00f4ng n\u00ean ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c terfenadin, astemisol, cisarprid v\u00e0 c\u00e1c thu\u1ed1c c\u00f3 ph\u1ea1m vi \u0111i\u1ec1u tr\u1ecb h\u1eb9p chuy\u1ec3n h\u00f3a qua cytochrom P450 CYP3A4 (theo Martindal 36).<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h3><span class=\"ez-toc-section\" id=\"49-qua-lieu-va-xu-tri\"><\/span>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>C\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng trong th\u1eddi gian d\u00e0i \u0111\u00e3 \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh v\u1edbi li\u1ec1u l\u00ean \u0111\u1ebfn 200 mg bicalutamid m\u1ed7i ng\u00e0y v\u00e0 c\u00e1c li\u1ec1u n\u00e0y \u0111\u01b0\u1ee3c dung n\u1ea1p t\u1ed1t. Ch\u01b0a c\u00f3 tr\u01b0\u1eddng h\u1ee3p x\u1ea3y ra ng\u1ed9 \u0111\u1ed9c g\u00e2y nguy hi\u1ec3m t\u00ednh m\u1ea1ng sau khi s\u1eed d\u1ee5ng m\u1ed9t li\u1ec1u \u0111\u01a1n bicalutamid tr\u00ean l\u00e2m s\u00e0ng.<\/p>\n<p>Kh\u00f4ng c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1eb7c hi\u1ec7u cho bicalutamid, v\u00ec th\u1ebf khi qu\u00e1 li\u1ec1u bicalutamid, ch\u1ee7 y\u1ebfu l\u00e0 \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng.<\/p>\n<p>Trong ki\u1ec3m so\u00e1t qu\u00e1 li\u1ec1u bicalutamid, b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 b\u1ecb n\u00f4n m\u1eeda. C\u1ea7n ph\u1ea3i nh\u1edb r\u1eb1ng, c\u00e1c b\u1ec7nh nh\u00e2n n\u00e0y c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng r\u1ea5t nhi\u1ec1u thu\u1ed1c kh\u00e1c nhau. Th\u1ea9m ph\u00e2n c\u00f3 th\u1ec3 s\u1ebd kh\u00f4ng h\u1eefu hi\u1ec7u do bicalutamid g\u1eafn r\u1ea5t ch\u1eb7t v\u1edbi protein huy\u1ebft thanh v\u00e0 b\u1ecb chuy\u1ec3n h\u00f3a m\u1ea1nh. Ch\u0103m s\u00f3c h\u1ed7 tr\u1ee3, th\u01b0\u1eddng xuy\u00ean theo d\u00f5i d\u1ea5u hi\u1ec7u s\u1ed1ng c\u00f2n v\u00e0 theo d\u00f5i b\u1ec7nh nh\u00e2n ch\u1eb7t ch\u1ebd l\u00e0 c\u00e1c bi\u1ec7n ph\u00e1p \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o \u00e1p d\u1ee5ng.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"5-co-che-tac-dung-cua-thuoc\"><\/span><strong>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"51-duoc-luc-hoc\"><\/span>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Bicalutamid l\u00e0 thu\u1ed1c kh\u00e1ng androgen kh\u00f4ng thu\u1ed9c nh\u00f3m steroid. Thu\u1ed1c \u1ee9c ch\u1ebf c\u1ea1nh tranh v\u1edbi androgen b\u1eb1ng c\u00e1ch g\u1eafn v\u00e0o th\u1ee5 th\u1ec3 androgen trong b\u00e0o t\u01b0\u01a1ng c\u1ee7a t\u1ebf b\u00e0o m\u00f4 \u0111\u00edch. Ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t l\u00e0 d\u1ea1ng ung th\u01b0 nh\u1ea1y c\u1ea3m v\u1edbi androgen v\u00e0 \u0111\u00e1p \u1ee9ng v\u1edbi tr\u1ecb li\u1ec7u b\u1eb1ng c\u00e1c thu\u1ed1c t\u00e1c \u0111\u1ed9ng tr\u00ean androgen ho\u1eb7c l\u00e0m gi\u1ea3m h\u00e0m l\u01b0\u1ee3ng androgen.<\/p>\n<p>Khi ph\u1ed1i h\u1ee3p bicalutamid v\u1edbi c\u00e1c thu\u1ed1c nh\u00f3m LHRH (luteinizing hormone-releasing hormone), bicalutamid kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn t\u00e1c \u0111\u1ed9ng \u1ee9c ch\u1ebf n\u1ed3ng \u0111\u1ed9 testosteron trong huy\u1ebft thanh c\u1ee7a c\u00e1c thu\u1ed1c nh\u00f3m LHRH. Tuy nhi\u00ean khi ch\u1ec9 s\u1eed d\u1ee5ng bicalutamid \u0111\u1ec1 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t trong th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng, n\u1ed3ng \u0111\u1ed9 testosteron v\u00e0 estradiol trong huy\u1ebft thanh c\u00f3 gia t\u0103ng.<\/p>\n<p>Trong m\u1ed9t ph\u00e2n nh\u00f3m b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb b\u1eb1ng bicalutamid v\u00e0 m\u1ed9t thu\u1ed1c LHRH agonist, v\u00e0 sau \u0111\u00f3 ng\u01b0ng tr\u1ecb li\u1ec7u b\u1eb1ng bicalutamid do ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t ti\u1ebfn tri\u1ec3n, k\u1ebft qu\u1ea3 cho th\u1ea5y c\u00f3 s\u1ef1 gi\u1ea3m kh\u00e1ng nguy\u00ean PSA (Prostate Specific Antigen) v\u00e0\/ho\u1eb7c c\u00f3 s\u1ef1 c\u1ea3i thi\u1ec7n tr\u00ean l\u00e2m s\u00e0ng (hi\u1ec7n t\u01b0\u1ee3ng ng\u01b0ng thu\u1ed1c kh\u00e1ng androgen).<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>Bicalutamide c\u1ea1nh tranh v\u1edbi androgen \u0111\u1ec3 li\u00ean k\u1ebft v\u1edbi c\u00e1c th\u1ee5 th\u1ec3 androgen, do \u0111\u00f3 ng\u0103n ch\u1eb7n k\u00edch ho\u1ea1t androgen c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb tuy\u1ebfn th\u01b0\u1ee3ng th\u1eadn v\u00e0 tinh ho\u00e0n, \u1ee9c ch\u1ebfho\u1ea1t \u0111\u1ed9ng c\u1ee7a k\u00edch th\u00edch s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a m\u00f4 tuy\u1ebfn ti\u1ec1n li\u1ec7t b\u00ecnh th\u01b0\u1eddng v\u00e0 \u00e1c t\u00ednh.<\/p>\n<p><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/p>\n<h3><span class=\"ez-toc-section\" id=\"52-duoc-dong-hoc\"><\/span>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><em>H\u1ea5p thu<\/em><\/p>\n<p>Bicalutamid \u0111\u01b0\u1ee3c h\u1ea5p thu t\u1ed1t qua \u0111\u01b0\u1eddng u\u1ed1ng m\u1eb7c d\u00f9 kh\u00f4ng x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c sinh kh\u1ea3 d\u1ee5ng tuy\u1ebft \u0111\u1ed1i. S\u1eed d\u1ee5ng bicalutamid v\u1edbi th\u1ee9c \u0103n kh\u00f4ng g\u00e2y t\u00e1c \u0111\u1ed9ng c\u00f3 \u00fd ngh\u0129a tr\u00ean l\u00e2m s\u00e0ng v\u1ec1 m\u1eb7t t\u1ed1c \u0111\u1ed9 v\u00e0 m\u1ee9c \u0111\u1ed9 h\u1ea5p thu.<\/p>\n<p><em>Ph\u00e2n b\u1ed1<\/em><\/p>\n<p>Bicalutamid g\u1eafn k\u1ebft r\u1ea5t cao v\u1edbi protein (96%).<\/p>\n<p><em>Chuy\u1ec3n h\u00f3a\/Th\u1ea3i tr\u1eeb<\/em><\/p>\n<p>Bicalutamid \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a v\u1ec1 m\u1eb7t c\u1ea5u h\u00ecnh kh\u00f4ng gian. \u0110\u1ed3ng ph\u00e2n S (kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh) \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu b\u1edfi s\u1ef1 li\u00ean h\u1ee3p v\u1edbi glucuronid. \u0110\u1ed3ng ph\u00e2n R (c\u00f3 ho\u1ea1t t\u00ednh) c\u0169ng li\u00ean h\u1ee3p v\u1edbi glucuronid nh\u01b0ng ch\u1ee7 y\u1ebfu l\u00e0 b\u1ecb oxy h\u00f3a th\u00e0nh ch\u1ea5t chuy\u1ec3n h\u00f3a kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh sau khi li\u00ean h\u1ee3p v\u1edbi glucuronid. C\u1ea3 2 d\u1ea1ng thu\u1ed1c ban \u0111\u1ea7u v\u00e0 thu\u1ed1c chuy\u1ec3n h\u00f3a li\u00ean h\u1ee3p v\u1edbi glucuronid \u0111\u1ec1u \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb qua n\u01b0\u1edbc ti\u1ec3u v\u00e0 ph\u00e2n.<\/p>\n<p>D\u1ea1ng \u0111\u1ed3ng ph\u00e2n S th\u1ea3i tr\u1eeb nhanh h\u01a1n so v\u1edbi \u0111\u1ed3ng ph\u00e2n R v\u00e0 \u0111\u1ed3ng ph\u00e2n R chi\u1ebfm kho\u1ea3ng 99% t\u1ed5ng h\u00e0m l\u01b0\u1ee3ng thu\u1ed1c trong huy\u1ebft t\u01b0\u01a1ng \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh.<\/p>\n<p>D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a \u0111\u1ed3ng ph\u00e2n c\u00f3 ho\u1ea1t t\u00ednh c\u1ee7a Bicalutamid trong nam gi\u1edbi t\u00ecnh nguy\u1ec7n kh\u1ecfe m\u1ea1nh v\u00e0 b\u1ec7nh nh\u00e2n ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t \u0111\u01b0\u1ee3c tr\u00ecnh b\u00e0y \u1edf B\u1ea3ng 1:<\/p>\n<table>\n<tbody>\n<tr>\n<td><strong>Th\u00f4ng s\u1ed1<\/strong><\/td>\n<td><strong>Gi\u00e1 tr\u1ecb trung b\u00ecnh<\/strong><\/td>\n<td><strong>\u0110\u1ed9 l\u1ec7ch chu\u1ea9n<\/strong><\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\"><strong>Nam gi\u1edbi kh\u1ecfe m\u1ea1nh (n=30)<\/strong><\/td>\n<\/tr>\n<tr>\n<td>\u0110\u1ed9 thanh th\u1ea3i bi\u1ebfu ki\u1ebfn qua \u0111\u01b0\u1eddng u\u1ed1nq (L\/gi\u1edd)<\/td>\n<td>0.320<\/td>\n<td>0,103<\/td>\n<\/tr>\n<tr>\n<td>N\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh sau 1 li\u1ec1u \u0111\u01a1n (\u00b5q\/mL)<\/td>\n<td>0,768<\/td>\n<td>0,178<\/td>\n<\/tr>\n<tr>\n<td>Th\u1eddi gian \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh sau 1 li\u1ec1u \u0111\u01a1n (gi\u1edd)<\/td>\n<td>31,3<\/td>\n<td>14,6<\/td>\n<\/tr>\n<tr>\n<td>Th\u1eddi gian b\u00e1n th\u1ea3i (ng\u00e0y)<\/td>\n<td>5,8<\/td>\n<td>2,29<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\"><strong>B\u1ec7nh nh\u00e2n ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t (n=40)<\/strong><\/td>\n<\/tr>\n<tr>\n<td>N\u1ed3ng \u0111\u1ed9 trung binh \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh Css (\u00b5q\/mL)<\/td>\n<td>8,939<\/td>\n<td>3,504<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\">Css= Mean Steady-State Concentration<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3><span class=\"ez-toc-section\" id=\"53-hieu-qua-lam-sang\"><\/span>5.3. Hi\u1ec7u qu\u1ea3 l\u00e2m s\u00e0ng:<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"54-du-lieu-tien-lam-sang\"><\/span>5.4. D\u1eef li\u1ec7u ti\u1ec1n l\u00e2m s\u00e0ng:<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<h2><span class=\"ez-toc-section\" id=\"6-phan-thong-tin-kem-theo-cua-thuoc\"><\/span><strong>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"61-danh-muc-ta-duoc\"><\/span>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Lactose Monohydrat, Tinh b\u1ed9t Natri Glyconat, Silicon Dioxid keo, Povidon K-30, Magnesi Stearat, Opadry White (Y-1-7000), n\u01b0\u1edbc c\u1ea5t pha ti\u00eam v\u1eeba \u0111\u1ee7.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"62-tuong-ky\"><\/span>6.2. T\u01b0\u01a1ng k\u1ef5 :<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Kh\u00f4ng c\u00f3 th\u00f4ng tin.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"63-bao-quan\"><\/span>6.3. B\u1ea3o qu\u1ea3n:<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>B\u1ea3o qu\u1ea3n d\u01b0\u1edbi 30\u00b0C, tr\u00e1nh \u00e1nh s\u00e1ng.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"64-thong-tin-khac\"><\/span>6.4. Th\u00f4ng tin kh\u00e1c :<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><em>M\u00f4 t\u1ea3 s\u1ea3n ph\u1ea9m<\/em>:<\/p>\n<p>Bicalutamid l\u00e0 thu\u1ed1c kh\u00e1ng androgen kh\u00f4ng thu\u1ed9c nh\u00f3m steroid v\u00ec th\u1ebf tr\u00e1nh \u0111\u01b0\u1ee3c m\u1ed9t s\u1ed1 t\u00e1c \u0111\u1ed9ng kh\u00e1c tr\u00ean n\u1ed9i ti\u1ebft. Thu\u1ed1c c\u1ea1nh tranh v\u1edbi androgen tr\u00ean th\u1ee5 th\u1ec3 androgen. Bicalutamid kh\u00f4ng \u1ee9c ch\u1ebf s\u1ef1 s\u1ea3n xu\u1ea5t androgen v\u00e0 c\u00f3 th\u1ebb l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 androgen trong huy\u1ebft thanh.<\/p>\n<p>BYPRO l\u00e0 d\u1ea1ng vi\u00ean bao phim c\u00f3 m\u00e0u tr\u1eafng hay tr\u1eafng nh\u1ea1t, hai \u0111\u1ea7u l\u1ed3i, c\u00f3 kh\u1eafc ch\u1eef \u201cDB01\u201d tr\u00ean 1 m\u1eb7t v\u00e0 m\u1eb7t kia tr\u01a1n.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"65-tai-lieu-tham-khao\"><\/span>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>HDSD Thu\u1ed1c Bypro do Fresenius Kabi Oncology Ltd. \u0111\u0103ng k\u00fd (2016).<\/p>\n<p><a href=\"https:\/\/drugbank.vn\/\">Ng\u00e2n h\u00e0ng d\u1eef li\u1ec7u ng\u00e0nh D\u01b0\u1ee3c<\/a>.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"7-nguoi-dang-tai-tac-gia\"><\/span><strong>7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>B\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c s\u01b0u t\u1ea7m ho\u1eb7c vi\u1ebft b\u1edfi: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-tac-gia-bac-sy-do-my-linh\/\">B\u00e1c s\u0129 nhi khoa &#8211; \u0110\u1ed7 M\u1ef9 Linh.<\/a><\/p>\n<p>Ki\u1ec3m duy\u1ec7t , hi\u1ec7u \u0111\u00ednh v\u00e0 \u0111\u0103ng t\u1ea3i: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-ve-pharmog-team\/\">PHARMOG TEAM<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bypro l\u00e0 thu\u1ed1c k\u00ea \u0111\u01a1n nh\u00f3m tr\u1ecb ung th\u01b0 do c\u00f4ng ty Fresenius Kabi Oncology Ltd s\u1ea3n xu\u1ea5t, thu\u1ed1c c\u00f3 ch\u1ee9a d\u01b0\u1ee3c ch\u1ea5t Bicalutamide. Bypro ng\u0103n ch\u1eb7n ho\u1ea1t \u0111\u1ed9ng c\u1ee7a hormone androgen v\u00e0 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t di c\u0103n giai \u0111o\u1ea1n D2.<\/p>\n","protected":false},"author":8612,"featured_media":60991,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[500],"class_list":["post-60974","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-bicalutamide"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/60974","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/8612"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=60974"}],"version-history":[{"count":5,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/60974\/revisions"}],"predecessor-version":[{"id":61030,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/60974\/revisions\/61030"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/60991"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=60974"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=60974"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=60974"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}