{"id":42442,"date":"2022-02-01T21:55:39","date_gmt":"2022-02-01T14:55:39","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=42442"},"modified":"2025-01-07T22:22:32","modified_gmt":"2025-01-07T15:22:32","slug":"pantoprazole-grasamin-ulpan","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/","title":{"rendered":"Pantoprazole &#8211; Grasamin\/Ulpan"},"content":{"rendered":"<p><em>Thu\u1ed1c Grasamin, Ulpan l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Grasamin, Ulpan (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;)<\/em><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_81 ez-toc-wrap-left counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">N\u1ed9i dung ch\u00ednh<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#1-ten-hoat-chat-va-biet-duoc\" >1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#2-dang-bao-che-%e2%80%93-ham-luong\" >2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#3-video-by-pharmog\" >3. Video by Pharmog:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#4-ung-dung-lam-sang\" >4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng:<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#41-chi-dinh\" >4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#42-lieu-dung-%e2%80%93-cach-dung\" >4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#43-chong-chi-dinh\" >4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#44-than-trong\" >4.4 Th\u1eadn tr\u1ecdng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#45-su-dung-cho-phu-nu-co-thai-va-cho-con-bu\" >4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#46-tac-dung-khong-mong-muon-adr\" >4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#47-huong-dan-cach-xu-tri-adr\" >4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#48-tuong-tac-voi-cac-thuoc-khac\" >4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#49-qua-lieu-va-xu-tri\" >4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#5-co-che-tac-dung-cua-thuoc\" >5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#51-duoc-luc-hoc\" >5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#52-duoc-dong-hoc\" >5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#53-giai-thich\" >5.3 Gi\u1ea3i th\u00edch:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#54-thay-the-thuoc\" >5.4 Thay th\u1ebf thu\u1ed1c :<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#6-phan-thong-tin-kem-theo-cua-thuoc\" >6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#61-danh-muc-ta-duoc\" >6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#62-tuong-ky\" >6.2. T\u01b0\u01a1ng k\u1ef5 :<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#63-bao-quan\" >6.3. B\u1ea3o qu\u1ea3n:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#64-thong-tin-khac\" >6.4. Th\u00f4ng tin kh\u00e1c :<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#65-tai-lieu-tham-khao\" >6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-grasamin-ulpan\/#7-nguoi-dang-tai-tac-gia\" >7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<\/a><\/li><\/ul><\/nav><\/div>\n\n<h1><span class=\"ez-toc-section\" id=\"1-ten-hoat-chat-va-biet-duoc\"><\/span>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <\/strong><a href=\"https:\/\/pharmog.com\/wp\/pantoprazole\/\"><strong>Pantoprazole<\/strong><\/a><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u00f4\u0301c \u01b0\u0301c ch\u00ea\u0301 b\u01a1m Proton. Thu\u1ed1c \u1ee9c ch\u1ebf ti\u1ebft acid d\u1ea1 d\u00e0y.<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): A02BC02.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em><\/strong> <a href=\"https:\/\/pharmog.com\/wp\/pantoprazole-pantoloc\/\">Pantoloc<\/a><\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c:<\/em><\/strong> Grasamin, Ulpan<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: Gracure Pharmaceuticals Ltd.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h1><span class=\"ez-toc-section\" id=\"2-dang-bao-che-%e2%80%93-ham-luong\"><\/span>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>Vi\u00ean n\u00e9n bao tan trong ru\u1ed9t 40 mg.<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>ULPAN<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean n\u00e9n c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Pantoprazole<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>40 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"592\" height=\"315\" class=\"wp-image-42456\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2022\/02\/word-image-23.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2022\/02\/word-image-23.png 592w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2022\/02\/word-image-23-300x160.png 300w\" sizes=\"auto, (max-width: 592px) 100vw, 592px\" \/><\/p>\n<h1><span class=\"ez-toc-section\" id=\"3-video-by-pharmog\"><\/span>3. Video by Pharmog:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe loading=\"lazy\" title=\"[Pharmog SS1 - T\u1eadp 15] - D\u01b0\u1ee3c l\u00fd c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb vi\u00eam lo\u00e9t d\u1ea1 d\u00e0y t\u00e1 tr\u00e0ng\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/wgt47Xu6X-4?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<h1><span class=\"ez-toc-section\" id=\"4-ung-dung-lam-sang\"><\/span>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"41-chi-dinh\"><\/span>4.1. Ch\u1ec9 \u0111\u1ecbnh:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y &#8211; th\u1ef1c qu\u1ea3n.<\/p>\n<p>Lo\u00e9t d\u1ea1 d\u00e0y, t\u00e1 tr\u00e0ng.<\/p>\n<p>D\u1ef1 ph\u00f2ng lo\u00e9t d\u1ea1 d\u00e0y, t\u00e1 tr\u00e0ng do d\u00f9ng thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid, do stress.<\/p>\n<p>H\u1ed9i ch\u1ee9ng Zollinger &#8211; Ellison.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"42-lieu-dung-%e2%80%93-cach-dung\"><\/span>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p>\u0110\u01b0\u1eddng u\u1ed1ng.<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p><em>B\u1ec7nh tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y &#8211; th\u1ef1c qu\u1ea3n:<\/em> U\u1ed1ng m\u1ed7i ng\u00e0y m\u1ed9t l\u1ea7n t\u1eeb 20 &#8211; 40 mg v\u00e0o bu\u1ed5i s\u00e1ng trong 4 tu\u1ea7n, c\u00f3 th\u1ec3 t\u0103ng t\u1edbi 8 tu\u1ea7n n\u1ebfu c\u1ea7n thi\u1ebft. \u0110\u1ec3 l\u00e0nh vi\u00eam tr\u1ee3t th\u1ef1c qu\u1ea3n, \u0111i\u1ec1u tr\u1ecb c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ph\u00e9p k\u00e9o d\u00e0i \u0111\u1ebfn 16 tu\u1ea7n.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb duy tr\u00ec c\u00f3 th\u1ec3 ti\u1ebfp t\u1ee5c v\u1edbi 20 t\u1edbi 40 mg m\u1ed7i ng\u00e0y. M\u1ed9t c\u00e1ch kh\u00e1c, v\u1edbi c\u00e1c tri\u1ec7u ch\u1ee9ng hay t\u00e1i di\u1ec5n, c\u00f3 th\u1ec3 d\u00f9ng ph\u00e1c \u0111\u1ed3 20 mg m\u1ed7i ng\u00e0y theo nhu c\u1ea7u.<\/p>\n<p><em>Lo\u00e9t d\u1ea1 d\u00e0y &#8211; t\u00e1 tr\u00e0ng:<\/em> U\u1ed1ng m\u1ed7i ng\u00e0y m\u1ed9t l\u1ea7n 40 mg trong 2 &#8211; 4 tu\u1ea7n \u0111\u1ed1i v\u1edbi lo\u00e9t t\u00e1 tr\u00e0ng v\u00e0 4 &#8211; 8 tu\u1ea7n \u0111\u1ed1i v\u1edbi lo\u00e9t d\u1ea1 d\u1ea7y l\u00e0nh t\u00ednh. \u0110\u1ec3 ti\u1ec7t tr\u1eeb <em>H. pylori,<\/em> c\u00f3 th\u1ec3 ph\u1ed1i h\u1ee3p pantoprazol v\u1edbi 2 kh\u00e1ng sinh trong ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb 3 thu\u1ed1c ho\u1eb7c 4 thu\u1ed1c trong m\u1ed9t tu\u1ea7n. M\u1ed9t ph\u00e1c \u0111\u1ed3 hi\u1ec7u qu\u1ea3 g\u1ed3m pantoprazol 40 mg, 2 l\u1ea7n m\u1ed7i ng\u00e0y (u\u1ed1ng bu\u1ed5i s\u00e1ng v\u00e0 t\u1ed1i) ph\u1ed1i h\u1ee3p v\u1edbi clarithromycin 500 mg, ng\u00e0y 2 l\u1ea7n v\u00e0 amoxicilin 1 g, ng\u00e0y 2 l\u1ea7n ho\u1eb7c ph\u1ed1i h\u1ee3p v\u1edbi clarithromycin 250 mg, ng\u00e0y 2 l\u1ea7n v\u00e0 metronidazol 400 mg, ng\u00e0y 2 l\u1ea7n.<\/p>\n<p><em>D\u1ef1 ph\u00f2ng lo\u00e9t \u0111\u01b0\u1eddng ti\u00eau h\u00f3a do thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid, <\/em>u\u1ed1ng ng\u00e0y m\u1ed9t l\u1ea7n 20 mg.<\/p>\n<p><em>T\u00ecnh tr\u1ea1ng t\u0103ng ti\u1ebft acid b\u1ec7nh l\u00fd trong h\u1ed9i ch\u1ee9ng Zollinger &#8211; Ellison:<\/em> U\u1ed1ng li\u1ec1u kh\u1edfi \u0111\u1ea7u l\u00e0 80 mg m\u1ed7i ng\u00e0y sau \u0111\u00f3 \u0111i\u1ec1u ch\u1ec9nh theo y\u00eau c\u1ea7u, c\u00f3 th\u1ec3 l\u00ean t\u1edbi 240 mg m\u1ed7i ng\u00e0y. N\u1ebfu li\u1ec1u h\u00e0ng ng\u00e0y l\u1edbn h\u01a1n 80 mg th\u00ec chia l\u00e0m 2 l\u1ea7n.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"43-chong-chi-dinh\"><\/span>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Kh\u00f4ng d\u00f9ng \u1edf ng\u01b0\u1eddi qu\u00e1 m\u1eabn c\u1ea3m v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c<\/p>\n<h2><span class=\"ez-toc-section\" id=\"44-than-trong\"><\/span>4.4 Th\u1eadn tr\u1ecdng:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>Suy gan<\/em><\/p>\n<p>\u1ede nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb suy gan n\u1eb7ng, \u0111\u1eb7c bi\u1ec7t l\u00e0 nh\u1eefng ng\u01b0\u1eddi \u0111i\u1ec1u tr\u1ecb d\u00e0i h\u1ea1n, n\u00ean theo d\u00f5i th\u01b0\u1eddng xuy\u00ean c\u00e1c men gan trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb v\u1edbi pantoprazol. Trong tr\u01b0\u1eddng h\u1ee3p t\u0103ng men gan, n\u00ean ng\u01b0ng d\u00f9ng pantoprazol.<\/p>\n<p><em>Li\u1ec7u ph\u00e1p k\u1ebft h\u1ee3p<\/em><\/p>\n<p>Trong tr\u01b0\u1eddng h\u1ee3p \u0111i\u1ec1u tr\u1ecb k\u1ebft h\u1ee3p, n\u00ean tu\u00e2n th\u1ee7 h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng c\u1ee7a c\u00e1c thu\u1ed1c d\u00f9ng k\u1ebft h\u1ee3p.<\/p>\n<p><em>S\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>Khi c\u00f3 b\u1ea5t k\u1ef3 tri\u1ec7u ch\u1ee9ng c\u1ea3nh b\u00e1o n\u00e0o (v\u00ed d\u1ee5 nh\u01b0 gi\u1ea3m c\u00e2n \u0111\u00e1ng k\u1ec3 kh\u00f4ng ch\u1ee7 \u0111\u1ecbnh, n\u00f4n m\u1eeda, ch\u1ee9ng kh\u00f3 nu\u1ed1t, n\u00f4n ra m\u00e1u, thi\u1ebfu m\u00e1u ho\u1eb7c \u0111\u1ea1i ti\u1ec7n m\u00e1u \u0111en) v\u00e0 khi lo\u00e9t d\u1ea1 d\u00e0y ho\u1eb7c nghi ng\u1edd lo\u00e9t d\u1ea1 d\u00e0y, c\u1ea7n ph\u1ea3i lo\u1ea1i tr\u1eeb c\u00e1c tr\u01b0\u1eddng h\u1ee3p \u00e1c t\u00ednh do \u0111i\u1ec1u tr\u1ecb b\u1eb1ng pantoprazol c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m tri\u1ec7u ch\u1ee9ng v\u00e0 tr\u00ec ho\u00e3n ch\u1ea9n \u0111o\u00e1n.<\/p>\n<p>C\u1ea7n ti\u1ebfp t\u1ee5c xem x\u00e9t n\u1ebfu c\u00e1c tri\u1ec7u ch\u1ee9ng v\u1eabn t\u1ed3n t\u1ea1i m\u1eb7c d\u00f9 \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb \u0111\u1ea7y \u0111\u1ee7.<\/p>\n<p><em>D\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi atazanavir<\/em><\/p>\n<p>Kh\u00f4ng n\u00ean d\u00f9ng \u0111\u1ed3ng th\u1eddi atazanavir v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton. N\u1ebfu b\u1eaft bu\u1ed9c ph\u1ea3i d\u00f9ng \u0111\u1ed3ng th\u1eddi atazanavir v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton, n\u00ean theo d\u00f5i l\u00e2m s\u00e0ng ch\u1eb7t ch\u1ebd (x\u00e9t nghi\u1ec7m virus) k\u1ebft h\u1ee3p v\u1edbi t\u0103ng li\u1ec1u atazanavir l\u00ean 400mg v\u1edbi 100mg ritonavir. Li\u1ec1u pantoprazol kh\u00f4ng \u0111\u01b0\u1ee3c v\u01b0\u1ee3t qu\u00e1 20mg \/ ng\u00e0y.<\/p>\n<p><em>\u1ea2nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 h\u1ea5p thu vitamin B12<\/em><\/p>\n<p>\u1ede nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 h\u1ed9i ch\u1ee9ng Zollinger-Ellison v\u00e0 c\u00e1c tr\u01b0\u1eddng h\u1ee3p t\u0103ng ti\u1ebft b\u1ec7nh l\u00fd c\u1ea7n \u0111i\u1ec1u tr\u1ecb d\u00e0i h\u1ea1n, pantoprazol c\u0169ng nh\u01b0 t\u1ea5t c\u1ea3 c\u00e1c lo\u1ea1i thu\u1ed1c gi\u1ea3m ti\u1ebft acid c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m h\u1ea5p thu vitamin B12 (cyanocobalamin) do thi\u1ebfu acid d\u1ecbch v\u1ecb. c\u1ea7n th\u1eadn tr\u1ecdng \u1edf b\u1ec7nh nh\u00e2n l\u01b0\u1ee3ng vitamin B12 d\u1ef1 tr\u1eef th\u1ea5p ho\u1eb7c c\u00f3 c\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1 g\u00e2y gi\u1ea3m h\u1ea5p thu vitamin B12 ho\u1eb7c khi quan s\u00e1t th\u1ea5y c\u00e1c tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng c\u1ee7a vi\u1ec7c gi\u1ea3m vitamin B12 khi \u0111i\u1ec1u tr\u1ecb d\u00e0i h\u1ea1n b\u1eb1ng pantoprazol.<\/p>\n<p><em>\u0110i\u1ec1u tr\u1ecb d\u00e0i h\u1ea1n<\/em><\/p>\n<p>Khi \u0111i\u1ec1u tr\u1ecb d\u00e0i h\u1ea1n, \u0111\u1eb7c bi\u1ec7t khi \u0111i\u1ec1u tr\u1ecb tr\u00ean 1 n\u0103m, b\u1ec7nh nh\u00e2n n\u00ean \u0111\u01b0\u1ee3c theo d\u00f5i th\u01b0\u00f2ng xuy\u00ean. Nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng ti\u00eau ho\u00e1 do vi khu\u1ea9n<\/p>\n<p>Pantoprazol, gi\u1ed1ng nh\u01b0 t\u1ea5t c\u1ea3 c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton kh\u00e1c, c\u00f3 th\u1ec3 l\u00e0m gia t\u0103ng s\u1ed1 l\u01b0\u1ecdng vi khu\u1ea9n th\u01b0\u1eddng c\u00f3 \u1edf \u0111\u01b0\u1eddng ti\u00eau h\u00f3a tr\u00ean. \u0110i\u1ec1u tr\u1ecb b\u1eb1ng pantoprazol c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng ti\u00eau h\u00f3a do c\u00e1c vi khu\u1ea9n nh\u01b0 Salmonella v\u00e0 Campylobacter v\u00e0 C.difficile.<\/p>\n<p><em>Gi\u1ea3m magi\u00ea m\u00e1u<\/em><\/p>\n<p>Gi\u1ea3m magi\u00ea m\u00e1u tr\u1ea7m tr\u1ecdng \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb b\u1eb1ng c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton nh\u01b0 pantoprazol trong \u00edt nh\u1ea5t ba th\u00e1ng v\u00e0 trong h\u1ea7u h\u1ebft c\u00e1c tr\u01b0\u1eddng h\u1ee3p \u0111i\u1ec1u tr\u1ecb trong m\u1ed9t n\u0103m. C\u00e1c bi\u1ec3u hi\u1ec7n nghi\u00eam tr\u1ecdng c\u1ee7a h\u1ea1 magi\u00ea m\u00e1u nh\u01b0 m\u1ec7t m\u1ecfi, \u0111au th\u1eaft l\u01b0ng, co gi\u1eadt, ch\u00f3ng m\u1eb7t v\u00e0 lo\u1ea1n nh\u1ecbp th\u1ea5t c\u00f3 th\u1ec3 x\u1ea3y ra, nh\u01b0ng c\u00f3 th\u1ec3 b\u1eaft \u0111\u1ea7u m\u1ed9t c\u00e1ch \u00e2m th\u1ea7m v\u00e0 b\u1ecb b\u1ecf s\u00f3t. \u1ede h\u1ea7u h\u1ebft c\u00e1c tr\u01b0\u1eddng h\u1ee3p, gi\u1ea3m magi\u00ea m\u00e1u d\u01b0\u1ee3c c\u1ea3i thi\u1ec7n sau khi b\u1ed5 sung th\u00eam magi\u00ea v\u00e0 ng\u01b0ng s\u1eed d\u1ef1ng c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton.<\/p>\n<p>\u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n d\u1ef1 ki\u1ebfn s\u1ebd \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb k\u00e9o d\u00e0i ho\u1eb7c d\u00f9ng c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton v\u1edbi digoxin ho\u1eb7c c\u00e1c thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y gi\u1ea3m magi\u00ea m\u00e1u (v\u00ed d\u1ee5 thu\u1ed1c l\u1ee3i ti\u1ec3u), c\u00e1c th\u1ea7y thu\u1ed1c n\u00ean ki\u1ec3m tra n\u1ed3ng \u0111\u1ed9 magi\u00ea tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb b\u1eb1ng c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton v\u00e0 \u0111\u1ecbnh k\u1ef3 trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p><em>G\u00e3y x\u01b0\u01a1ng<\/em><\/p>\n<p>Thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton, \u0111\u1eb7c bi\u1ec7t n\u1ebfu d\u00f9ng li\u1ec1u cao v\u00e0 trong th\u1eddi gian d\u00e0i (&gt; 1 n\u0103m), c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 g\u00e3y x\u01b0\u01a1ng h\u00f4ng, c\u1ed5 tay v\u00e0 c\u1ed9t s\u1ed1ng, ch\u1ee7 y\u1ebfu \u1edf ng\u01b0\u1eddi cao tu\u1ed5i ho\u1eb7c ng\u01b0\u1eddi c\u00f3 c\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1 kh\u00e1c.<\/p>\n<p><em>Tr\u1ebb em<\/em><\/p>\n<p>Cho \u0111\u1ebfn nay ch\u01b0a c\u00f3 kinh nghi\u1ec7m \u0111i\u1ec1u tr\u1ecb \u1edf tr\u1ebb em.<\/p>\n<p><em>L\u01b0u \u00fd<\/em><\/p>\n<p>Tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb lo\u00e9t d\u1ea1 d\u00e0y, c\u1ea7n lo\u1ea1i tr\u1eeb kh\u1ea3 n\u0103ng \u00e1c t\u00ednh khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng pantoprazol do thu\u1ed1c c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m c\u00e1c tri\u1ec7u ch\u1ee9ng lo\u00e9t \u00e1c t\u00ednh v\u00e0 do \u0111\u00f3 c\u00f3 th\u1ec3 tr\u00ec ho\u00e3n vi\u1ec7c ch\u1ea9n \u0111o\u00e1n.<\/p>\n<p><em>B\u1ec7nh lupus ban \u0111\u1ecf <\/em><\/p>\n<p>Thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton c\u00f3 li\u00ean quan \u0111\u1ebfn c\u00e1c tr\u01b0\u1eddng h\u1ee3p r\u1ea5t hi\u1ebfm c\u1ee7a b\u1ec7nh lupus ban \u0111\u1ecf. N\u1ebfu t\u1ed5n th\u01b0\u01a1ng x\u1ea3y ra, \u0111\u1eb7c bi\u1ec7t l\u00e0 trong v\u00f9ng da ti\u1ebfp x\u00fac v\u1edbi \u00e1nh n\u1eafng m\u1eb7t tr\u1eddi, v\u00e0 n\u1ebfu k\u00e8m theo \u0111au kh\u1edbp, b\u1ec7nh nh\u00e2n c\u1ea7n nhanh ch\u00f3ng t\u00ecm \u0111\u1ebfn tr\u1ee3 gi\u00fap y t\u1ebf v\u00e0 th\u1ea7y thu\u1ed1c n\u00ean c\u00e2n nh\u1eafc ng\u1eebng d\u00f9ng pantoprazol. B\u1ec7nh nh\u00e2n \u0111\u00e3 t\u1eebng b\u1ecb b\u1ec7nh lupus ban \u0111\u1ecf sau khi \u0111i\u1ec1u tr\u1ecb v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton n\u00e0y c\u00f3 th\u1ec3 t\u0103ng nguy c\u01a1 m\u1eafc b\u1ec7nh lupus ban \u0111\u1ecf khi d\u00f9ng c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton kh\u00e1c.<\/p>\n<p><em>\u1ea2nh h\u01b0\u1edfng \u0111\u1ebfn c\u00e1c x\u00e9t nghi\u1ec7m<\/em><\/p>\n<p>Thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y t\u0103ng Chromogranin A (CgA), do \u0111\u00f3 c\u00f3 th\u1ec3 g\u00e2y c\u1ea3n tr\u1edf cho vi\u1ec7c x\u00e9t nghi\u1ec7m c\u00e1c kh\u1ed1i u th\u1ea7n kinh. \u0110\u1ec3 tr\u00e1nh s\u1ef1 \u1ea3nh h\u01b0\u1edfng n\u00e0y, n\u00ean ng\u1eebng \u0111i\u1ec1u tr\u1ecb b\u1eb1ng pantoprazol trong \u00edt nh\u1ea5t 5 ng\u00e0y tr\u01b0\u1edbc khi x\u00e9t nghi\u1ec7m CgA. N\u1ebfu sau khi x\u00e9t nghi\u1ec7m l\u1ea7n \u0111\u1ea7u ti\u00ean, n\u1ed3ng \u0111\u1ed9 CgA v\u00e0 gastrin kh\u00f4ng n\u1eb1m trong gi\u1edbi h\u1ea1n, ph\u1ea3i ti\u1ebfn h\u00e0nh x\u00e9t nghi\u1ec7m l\u1ea1i sau khi ng\u1eebng \u0111i\u1ec1u tr\u1ecb thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton 14 ng\u00e0y.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>Pantoprazol kh\u00f4ng c\u00f3 \u1ea3nh h\u01b0\u1edfng ho\u1eb7c \u1ea3nh h\u01b0\u1edfng kh\u00f4ng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 s\u1eed d\u1ee5ng m\u00e1y m\u00f3c. C\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n nh\u01b0 ch\u00f3ng m\u1eb7t, r\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c c\u00f3 th\u1ec3 x\u1ea3y ra. N\u1ebfu b\u1ecb \u1ea3nh h\u01b0\u1edfng, b\u1ec7nh nh\u00e2n kh\u00f4ng n\u00ean l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"45-su-dung-cho-phu-nu-co-thai-va-cho-con-bu\"><\/span>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: B1<\/p>\n<p>US FDA pregnancy category: NA<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>Ch\u1ec9 s\u1eed d\u1ee5ng thu\u1ed1c cho ph\u1ee5 n\u1eef c\u00f3 thai khi th\u1ef1c s\u1ef1 c\u1ea7n thi\u1ebft.<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>Ch\u01b0a bi\u1ebft li\u1ec7u thu\u1ed1c c\u00f3 b\u00e0i ti\u1ebft qua s\u1eefa m\u1eb9 hay kh\u00f4ng, kh\u00f4ng n\u00ean cho con b\u00fa khi \u0111ang d\u00f9ng thu\u1ed1c.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"46-tac-dung-khong-mong-muon-adr\"><\/span>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Nh\u00ecn chung, pantoprazol dung n\u1ea1p t\u1ed1t c\u1ea3 khi \u0111i\u1ec1u tr\u1ecb ng\u1eafn h\u1ea1n v\u00e0 d\u00e0i h\u1ea1n. C\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton l\u00e0m gi\u1ea3m \u0111\u1ed9 acid \u1edf d\u1ea1 d\u00e0y, c\u00f3 th\u1ec3 t\u0103ng nguy c\u01a1 nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/p>\n<p><em>Th\u01b0\u1eddng g\u1eb7p, ADR &gt; 1\/100<\/em><\/p>\n<p>To\u00e0n th\u00e2n: m\u1ec7t, ch\u00f3ng m\u1eb7t, \u0111au \u0111\u1ea7u.<\/p>\n<p>Da: Ban da, m\u00e0y \u0111ay.<\/p>\n<p>Ti\u00eau h\u00f3a: Kh\u00f4 mi\u1ec7ng, bu\u1ed3n n\u00f4n, n\u00f4n, \u0111\u1ea7y h\u01a1i, \u0111au b\u1ee5ng, t\u00e1o b\u00f3n, \u1ec9a ch\u1ea3y.<\/p>\n<p>C\u01a1 kh\u1edbp: \u0110au c\u01a1, \u0111au kh\u1edbp.<\/p>\n<p><em>\u00cdt g\u1eb7p, 1\/1000 &lt; ADR &lt; 1\/100<\/em><\/p>\n<p>To\u00e0n th\u00e2n: Suy nh\u01b0\u1ee3c, cho\u00e1ng v\u00e1ng, ch\u00f3ng m\u1eb7t, m\u1ea5t ng\u1ee7.<\/p>\n<p>Da: Ng\u1ee9a.<\/p>\n<p>Gan: T\u0103ng enzym gan.<\/p>\n<p><em>Hi\u1ebfm g\u1eb7p, ADR &lt; 1\/1000<\/em><\/p>\n<p>To\u00e0n th\u00e2n: To\u00e1t m\u1ed3 h\u00f4i, ph\u00f9 ngo\u1ea1i bi\u00ean, t\u00ecnh tr\u1ea1ng kh\u00f3 ch\u1ecbu, ph\u1ea3n v\u1ec7.<\/p>\n<p>Da: Ban d\u00e1t s\u1ea7n, tr\u1ee9ng c\u00e1, r\u1ee5ng t\u00f3c, vi\u00eam da tr\u00f3c v\u1ea3y, ph\u00f9 m\u1ea1ch, h\u1ed3ng ban \u0111a d\u1ea1ng.<\/p>\n<p>Ti\u00eau h\u00f3a: Vi\u00eam mi\u1ec7ng, \u1ee3 h\u01a1i, r\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a.<\/p>\n<p>M\u1eaft: Nh\u00ecn m\u1edd, ch\u1ee9ng s\u1ee3 \u00e1nh s\u00e1ng.<\/p>\n<p>Th\u1ea7n kinh: M\u1ea5t ng\u1ee7, ng\u1ee7 g\u00e0, t\u00ecnh tr\u1ea1ng k\u00edch \u0111\u1ed9ng ho\u1eb7c \u1ee9c ch\u1ebf, \u00f9 tai, run, nh\u1ea7m l\u1eabn, \u1ea3o gi\u00e1c, d\u1ecb c\u1ea3m.<\/p>\n<p>M\u00e1u: T\u0103ng b\u1ea1ch c\u1ea7u \u01b0a acid, m\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t, gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m ti\u1ec3u c\u1ea7u.<\/p>\n<p>N\u1ed9i ti\u1ebft: Li\u1ec7t d\u01b0\u01a1ng, b\u1ea5t l\u1ef1c \u1edf nam gi\u1edbi.<\/p>\n<p>Ti\u1ebft ni\u1ec7u: \u0110\u00e1i m\u00e1u, vi\u00eam th\u1eadn k\u1ebd.<\/p>\n<p>Gan: Vi\u00eam gan, v\u00e0ng da, b\u1ec7nh n\u00e3o \u1edf ng\u01b0\u1eddi suy gan, t\u0103ng triglycerit.<\/p>\n<p>R\u1ed1i lo\u1ea1n ion: Gi\u1ea3m natr\u1ecb m\u00e1u.<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<h2><span class=\"ez-toc-section\" id=\"47-huong-dan-cach-xu-tri-adr\"><\/span>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Pantoprazol th\u01b0\u1eddng dung n\u1ea1p t\u1ed1t: \u0110au b\u1ee5ng, \u1ec9a ch\u1ea3y, nh\u1ee9c \u0111\u1ea7u, m\u1ec7t m\u1ecfi th\u01b0\u1eddng h\u1ebft khi ti\u1ebfp t\u1ee5c \u0111i\u1ec1u tr\u1ecb, r\u1ea5t \u00edt khi ph\u1ea3i ng\u1eebng thu\u1ed1c. C\u1ea7n ph\u1ea3i theo d\u00f5i c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u01b0 nh\u00ecn m\u1edd, tr\u1ea7m c\u1ea3m, vi\u00eam da, \u0111\u00e1i ra m\u00e1u, ph\u00e1t ban, li\u1ec7t d\u01b0\u01a1ng&#8230; N\u1ebfu k\u00e9o d\u00e0i ph\u1ea3i ng\u1eebng thu\u1ed1c ho\u1eb7c chuy\u1ec3n sang thu\u1ed1c kh\u00e1c<\/p>\n<h2><span class=\"ez-toc-section\" id=\"48-tuong-tac-voi-cac-thuoc-khac\"><\/span>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>C\u00e1c thu\u1ed1c c\u00f3 h\u1ea5p thu ph\u1ee5 thu\u1ed9c pH <\/em><\/p>\n<p>Do kh\u1ea3 n\u0103ng \u1ee9c ch\u1ebf ti\u1ebft acid d\u1ea1 d\u00e0y m\u1ea1nh v\u00e0 k\u00e9o d\u00e0i, pantoprazol c\u00f3 th\u1ec3 l\u00e0m \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 h\u1ea5p thu c\u1ee7a c\u00e1c thu\u1ed1c c\u00f3 h\u1ea5p thu ph\u1ee5 thu\u1ed9c pH d\u1ea1 d\u00e0y, v\u00ed d\u1ee5 m\u1ed9t v\u00e0i c\u00e1c thu\u1ed1c kh\u00e1ng n\u1ea5m azol nh\u01b0 ketoconazol, itraconazol, posaconazol v\u00e0 thu\u1ed1c kh\u00e1c nh\u01b0 erlotinib.<\/p>\n<p><em>Ch\u1ea5t \u1ee9c ch\u1ebf protease H1V<\/em><\/p>\n<p>Kh\u00f4ng n\u00ean d\u00f9ng \u0111\u1ed3ng th\u1eddi pantoprazol v\u1edbi c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf protease HIV m\u00e0 c\u00f3 s\u1ef1 h\u1ea5p thu ph\u1ee5 thu\u1ed9c pH acid d\u1ea1 d\u00e0y nh\u01b0 atazanavir do l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 sinh kh\u1ea3 d\u1ee5ng c\u1ee7a thu\u1ed1c. N\u1ebfu ph\u1ea3i d\u00f9ng ch\u1ea5t \u1ee9c ch\u1ebf protease H1V v\u1edbi m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf b\u01a1m proton, khuy\u1ebfn c\u00e1o n\u00ean theo d\u00f5i l\u00e2m s\u00e0ng ch\u1eb7t ch\u1ebd (v\u00ed d\u1ee5 x\u00e9t nghi\u1ec7m t\u1ea3i l\u01b0\u1ee3ng virus). Kh\u00f4ng d\u00f9ng qu\u00e1 li\u1ec1u pantoprazol 20 mg m\u1ed7i ng\u00e0y. C\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u d\u00f9ng c\u1ee7a c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf protease HIV.<\/p>\n<p><em>Thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u coumarin (phenprocoumon ho\u1eb7c wafarin)<\/em><\/p>\n<p>D\u00f9ng d\u1ed3ng th\u1eddi pantoprazol v\u1edbi wafarin ho\u1eb7c phenprocoumon kh\u00f4ng g\u00e2y \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a wafarin, phenprocoumon ho\u1eb7c ch\u1ec9 s\u1ed1 INR. Tuy nhi\u00ean, \u0111\u00e3 c\u00f3 b\u00e1o c\u00e1o v\u1ec1 vi\u1ec7c t\u0103ng ch\u1ec9 s\u1ed1 INR v\u00e0 th\u1eddi gian prothrombin \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf b\u01a1m proton v\u1edbi wafarin ho\u1eb7c phenprocoumon. T\u0103ng ch\u1ec9 s\u1ed1 INR v\u00e0 th\u1eddi gian prothrombin c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn ch\u1ea3y m\u00e1u b\u1ea5t th\u01b0\u1eddng, th\u1eadm ch\u00ed t\u1eed vong. N\u00ean theo d\u00f5i v\u1ec1 vi\u1ec7c t\u0103ng ch\u1ec9 s\u1ed1 INR v\u00e0 th\u1eddi gian prothrombin \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb v\u1edbi pantoprazol v\u00e0 wafarin ho\u1eb7c phenprocoumon.<\/p>\n<p><em>Methotrexate<\/em><\/p>\n<p>\u0110\u00e3 c\u00f3 b\u00e1o c\u00e1o v\u1ec1 vi\u1ec7c t\u0103ng n\u1ed3ng \u0111\u1ed9 methotrexate \u1edf m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n d\u00f9ng \u0111\u1ed3ng th\u1eddi methotrexate li\u1ec1u cao (v\u00ed d\u1ee5: 300 mg) v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton. Do \u0111\u00f3 n\u00ean xem x\u00e9t t\u1ea1m d\u1eebng pantoprazol \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n ph\u1ea3i d\u00f9ng methotrexat li\u1ec1u cao, v\u00ed d\u1ee5 nh\u01b0 b\u1ec7nh ung th\u01b0 v\u00e0 b\u1ec7nh v\u1ea3y n\u1ebfn.<\/p>\n<p><em>C\u00e1c t\u01b0\u01a1ng t\u00e1c kh\u00e1c<\/em><\/p>\n<p>Pantoprazol \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a r\u1ed9ng r\u00e3i \u1edf gan qua h\u1ec7 enzym Cytochrom P450. Con \u0111\u01b0\u1eddng chuy\u1ec3n h\u00f3a ch\u00ednh l\u00e0 s\u1ef1 kh\u1eed b\u1edfi CYP2C19 v\u00e0 con \u0111\u01b0\u1eddng chuy\u1ec3n h\u00f3a kh\u00e1c bao g\u1ed3m s\u1ef1 oxi h\u00f3a b\u1edfi CYP3A4.<\/p>\n<p>C\u00e1c nghi\u00ean c\u1ee9u t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c c\u0169ng chuy\u1ec3n h\u00f3a qua con \u0111\u01b0\u1eddng n\u00e0y nh\u01b0 Carbamazepin, diazepam, glibenclamid, nifedipin v\u00e0 thu\u1ed1c tr\u00e1nh thai \u0111\u01b0\u1eddng u\u1ed1ng ch\u1ee9a levonorgestrel v\u00e0 ethinyl oestradiol kh\u00f4ng cho th\u1ea5y t\u01b0\u01a1ng t\u00e1c c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng.<\/p>\n<p>Kh\u00f4ng lo\u1ea1i tr\u1eeb t\u01b0\u01a1ng t\u00e1c gi\u1eefa pantoprazol v\u1edbi c\u00e1c thu\u1ed1c ho\u1eb7c c\u00e1c h\u1ee3p ch\u1ea5t \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a qua c\u00f9ng m\u1ed9t h\u1ec7 enzym.<\/p>\n<p>K\u1ebft qu\u1ea3 t\u1eeb c\u00e1c nghi\u00ean c\u1ee9u cho th\u1ea5y pantoprazol kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 chuy\u1ec3n h\u00f3a c\u1ee7a c\u00e1c ch\u1ea5t \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1edfi CYP1A2 (nh\u01b0 cafein, theophyllin), CYP2C9 (nh\u01b0 piroxicam, diclofenac, naproxen), CYP2D6 (nh\u01b0 metoprolol), CYP2E1 (nh\u01b0 ethanol).<\/p>\n<p>Kh\u00f4ng c\u00f3 t\u01b0\u01a1ng t\u00e1c khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1ng acid.<\/p>\n<p>Kh\u00f4ng th\u1ea5y c\u00e1c t\u01b0\u01a1ng t\u00e1c c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng khi d\u00f9ng \u0111\u1ed3ng th\u1eddi pantoprazol v\u1edbi c\u00e1c kh\u00e1ng sinh nh\u01b0 clarithromycin, metronidazol, amoxicillin.<\/p>\n<p><em>C\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf ho\u1eb7c k\u00edch th\u00edch CYP2C19:<\/em><\/p>\n<p>C\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf CYP2C19 nh\u01b0 fluvoxamin c\u00f3 th\u1ec3 g\u00e2y t\u0103ng h\u1ea5p thu c\u1ee7a pantoprazol. N\u00ean xem x\u00e9t gi\u1ea3m li\u1ec1u \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb v\u1edbi pantoprazol li\u1ec1u cao, ho\u1eb7c b\u1ec7nh nh\u00e2n suy gan n\u1eb7ng.<\/p>\n<p>C\u00e1c ch\u1ea5t c\u1ea3m \u1ee9ng enzym \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn CYP2C19 v\u00e0 CYP3A4 nh\u01b0 rifampicin v\u00e0 ST John \u2018s wort (Hypericum perforatum) c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 c\u1ee7a c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton trong huy\u1ebft t\u01b0\u01a1ng m\u00e0 \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a qua h\u1ec7 enzym n\u00e0y.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"49-qua-lieu-va-xu-tri\"><\/span>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Hi\u1ec7n ch\u01b0a bi\u1ebft tri\u1ec7u ch\u1ee9ng khi d\u00f9ng qu\u00e1 li\u1ec1u \u1edf ng\u01b0\u1eddi. Trong tr\u01b0\u1eddng h\u1ee3p d\u00f9ng qu\u00e1 li\u1ec1u v\u00e0 c\u00f3 tri\u1ec7u ch\u1ee9ng nhi\u1ec5m \u0111\u1ed9c l\u00e2m s\u00e0ng, \u00e1p d\u1ee5ng c\u00e1c quy t\u1eafc gi\u1ea3i \u0111\u1ed9c th\u00f4ng th\u01b0\u1eddng.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h1><span class=\"ez-toc-section\" id=\"5-co-che-tac-dung-cua-thuoc\"><\/span>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"51-duoc-luc-hoc\"><\/span>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Pantoprazol l\u00e0 d\u1eabn ch\u1ea5t c\u1ee7a benzimidazol c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc b\u01a1m proton. N\u00f3 ng\u0103n c\u1ea3n b\u01b0\u1edbc cu\u1ed1i c\u00f9ng c\u1ee7a s\u1ef1 ti\u1ebft acid d\u1ea1 d\u00e0y b\u1edfi s\u1ef1 h\u00ecnh th\u00e0nh m\u1ed9t li\u00ean k\u1ebft \u0111\u1ed3ng ho\u00e1 tr\u1ecb \u1edf 2 v\u1ecb tr\u00ed c\u1ee7a h\u1ec7 th\u1ed1ng men (H+, K+)-ATPase \u1edf b\u1ec1 m\u1eb7t ti\u1ebft c\u1ee7a t\u1ebf b\u00e0o th\u00e0nh d\u1ea1 d\u00e0y. T\u00e1c d\u1ee5ng n\u00e0y c\u00f3 li\u00ean quan \u0111\u1ebfn li\u1ec1u d\u00f9ng v\u00e0 d\u1eabn \u0111\u1ebfn \u1ee9c ch\u1ebf c\u1ea3 s\u1ef1 ti\u1ebft acid d\u1ea1 d\u00e0y c\u01a1 b\u1ea3n v\u00e0 c\u1ea3 khi b\u1ecb k\u00edch th\u00edch m\u00e0 kh\u00f4ng k\u1ec3 t\u1edbi t\u00e1c nh\u00e2n k\u00edch th\u00edch. S\u1ef1 g\u1eafn k\u1ebft v\u1edbi (H+, K+)-ATPase g\u00e2y ra s\u1ef1 kh\u00e1ng ti\u1ebft k\u00e9o d\u00e0i h\u01a1n 24 gi\u1edd. Pantoprazol c\u00f3 t\u00e1c d\u1ee5ng t\u1ed1t h\u01a1n lansoprazol v\u00e0 Omeprazol.<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>Pantoprazol l\u00e0 thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton, \u1ee9c ch\u1ebf giai \u0111o\u1ea1n cu\u1ed1i trong qu\u00e1 tr\u00ecnh t\u1ea1o th\u00e0nh acid \u1edf d\u1ea1 d\u00e0y b\u1eb1ng li\u00ean k\u1ebft d\u00f2ng h\u00f3a tr\u1ecb v\u1edbi h\u1ec7 men (H<sup>+<\/sup>, K<sup>+<\/sup>) &#8211; ATPase t\u1ea1i b\u1ec1 m\u1eb7t k\u00edch th\u00edch b\u00e0i ti\u1ebft c\u1ee7a t\u1ebf b\u00e0o th\u00e0nh d\u1ea1 d\u00e0y. C\u01a1 ch\u1ebf n\u00e0y d\u1eabn \u0111\u1ebfn \u1ee9c ch\u1ebf c\u1ea3 hai c\u01a1 ch\u1ebf ti\u1ebft acid d\u1ea1 d\u00e0y th\u00f4ng th\u01b0\u1eddng v\u00e0 do c\u00e1c t\u00e1c nh\u00e2n k\u00edch th\u00edch. S\u1ef1 g\u1eafn k\u1ebft v\u1edbi h\u1ec7 men (H<sup>+<\/sup>,K<sup>+<\/sup>) &#8211; ATPase s\u1ebd l\u00e0m t\u00e1c d\u1ee5ng kh\u00e1ng ti\u1ebft acid k\u00e9o d\u00e0i h\u01a1n 24 gi\u1edd.<\/p>\n<p><a href=\"https:\/\/www.youtube.com\/watch?v=wgt47Xu6X-4\"><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/a><\/p>\n<h2><span class=\"ez-toc-section\" id=\"52-duoc-dong-hoc\"><\/span>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Pantoprazol \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh, \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh Cmax 2,5 mcg\/ml sau kho\u1ea3ng 2,5 gi\u1edd u\u1ed1ng m\u1ed9t li\u1ec1u ho\u1eb7c nhi\u1ec1u li\u1ec1u 40 mg. Pantoprazol \u0111\u01b0\u1ee3c h\u1ea5p thu t\u1ed1t, thu\u1ed1c m\u1ed9t ph\u1ea7n nh\u1ecf tr\u1ea3i qua giai \u0111o\u1ea1n chuy\u1ec3n ho\u00e1 \u0111\u1ea7u ti\u00ean v\u00e0 sinh kh\u1ea3 d\u1ee5ng tuy\u1ec7t \u0111\u1ed1i kho\u1ea3ng 77%. S\u1ef1 h\u1ea5p thu c\u1ee7a pantoprazol kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng c\u1ee7a c\u00e1c thu\u1ed1c kh\u00e1ng acid khi d\u00f9ng \u0111\u1ed3ng th\u1eddi. Th\u1ee9c \u0103n l\u00e0m ch\u1eadm s\u1ef1 h\u1ea5p thu c\u1ee7a pantoprazol t\u1edbi 2 gi\u1edd ho\u1eb7c l\u00e2u h\u01a1n, tuy nhi\u00ean n\u1ed3ng \u0111\u1ed9 Cmax v\u00e0 s\u1ef1 ph\u00e2n b\u1ed1, h\u1ea5p thu c\u1ee7a p- pantoprazol kh\u00f4ng thay \u0111\u1ed5i. V\u00ec v\u1eady c\u00f3 th\u1ec3 u\u1ed1ng pantoprazol l\u00fac \u0111\u00f3i ho\u1eb7c l\u00fac no.<\/p>\n<p>Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 c\u1ee7a pantoprazol l\u00e0 kho\u1ea3ng 11,0-23,6 l\u00edt, thu\u1ed1c \u0111\u01b0\u1ee3c ph\u00e2n b\u1ed1 ch\u1ee7 y\u1ebfu \u1edf d\u1ecbch ngo\u00e0i t\u1ebf b\u00e0o. Pantoprazol g\u1eafn k\u1ebft v\u1edbi protein huy\u1ebft thanh kho\u1ea3ng 98%, ch\u1ee7 y\u1ebfu v\u1edbi albumin. Pantoprazol chuy\u1ec3n ho\u00e1 ch\u1ee7 y\u1ebfu \u1edf gan. S\u1ef1 chuy\u1ec3n ho\u00e1 c\u1ee7a pantoprazol kh\u00f4ng b\u1ecb ph\u1ee5 thu\u1ed9c v\u00e0o \u0111\u01b0\u1eddng d\u00f9ng (u\u1ed1ng hay ti\u00eam t\u0129nh m\u1ea1ch). \u0110\u01b0\u1eddng chuy\u1ec3n ho\u00e1 ch\u00ednh l\u00e0 demethyl ho\u00e1 b\u1edfi CYP2C19, sau \u0111\u00f3 b\u1ecb sulphat ho\u00e1, c\u00e1c \u0111\u01b0\u1eddng chuy\u1ec3n ho\u00e1 kh\u00e1c l\u00e0 s\u1ef1 oxy ho\u00e1 b\u1edfi CYP3A4.<\/p>\n<p>Kho\u1ea3ng 71% thu\u1ed1c \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb qua n\u01b0\u1edbc ti\u1ec3u v\u00e0 18% \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb qua ph\u00e2n qua s\u1ef1 b\u00e0i ti\u1ebft \u1edf m\u1eadt. Kh\u00f4ng th\u1ea5y pantoprazol \u1edf d\u1ea1ng kh\u00f4ng bi\u1ebfn \u0111\u1ed5i b\u00e0i ti\u1ebft qua th\u1eadn.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"53-giai-thich\"><\/span>5.3 Gi\u1ea3i th\u00edch:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"54-thay-the-thuoc\"><\/span>5.4 Thay th\u1ebf thu\u1ed1c :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h1><span class=\"ez-toc-section\" id=\"6-phan-thong-tin-kem-theo-cua-thuoc\"><\/span>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"61-danh-muc-ta-duoc\"><\/span>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Manitol, magnesi oxid, natr\u1ecb methyl hydroxybenzoat, natr\u1ecb propyl hydroxybenzoat, povidon (poly vinyl pyrolidon K-30), talc, magnesi stearat, natr\u1ecb starch glycolat, croscarmellose natri, dicloromethan, titan dioxld, macrogol-6000, cellacefat (cellulose acetat phthalat), ethyl cellulose, col. iron oxid yellow lake<\/p>\n<h2><span class=\"ez-toc-section\" id=\"62-tuong-ky\"><\/span>6.2. T\u01b0\u01a1ng k\u1ef5 :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Kh\u00f4ng \u00e1p d\u1ee5ng.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"63-bao-quan\"><\/span>6.3. B\u1ea3o qu\u1ea3n:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>N\u01a1i kh\u00f4, tr\u00e1nh \u00e1nh s\u00e1ng, nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30\u00b0C.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"64-thong-tin-khac\"><\/span>6.4. Th\u00f4ng tin kh\u00e1c :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Kh\u00f4ng c\u00f3.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"65-tai-lieu-tham-khao\"><\/span>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>HDSD Thu\u1ed1c Ulpan do Gracure Pharmaceuticals Ltd. s\u1ea3n xu\u1ea5t (2019).<\/p>\n<h1><span class=\"ez-toc-section\" id=\"7-nguoi-dang-tai-tac-gia\"><\/span>7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p>B\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c s\u01b0u t\u1ea7m ho\u1eb7c vi\u1ebft b\u1edfi: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-tac-gia-bac-sy-do-my-linh\/\">B\u00e1c s\u0129 nhi khoa &#8211; \u0110\u1ed7 M\u1ef9 Linh.<\/a><\/p>\n<p>Ki\u1ec3m duy\u1ec7t , hi\u1ec7u \u0111\u00ednh v\u00e0 \u0111\u0103ng t\u1ea3i: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-ve-pharmog-team\/\">PHARMOG TEAM<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Grasamin, Ulpan l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Grasamin, Ulpan (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;) 1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Pantoprazole Ph\u00e2n lo\u1ea1i: Thu\u00f4\u0301c \u01b0\u0301c ch\u00ea\u0301 [&hellip;]<\/p>\n","protected":false},"author":8612,"featured_media":42456,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[1681],"class_list":["post-42442","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-pantoprazole"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/42442","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/8612"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=42442"}],"version-history":[{"count":1,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/42442\/revisions"}],"predecessor-version":[{"id":42469,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/42442\/revisions\/42469"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/42456"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=42442"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=42442"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=42442"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}