{"id":42439,"date":"2022-02-01T21:56:31","date_gmt":"2022-02-01T14:56:31","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=42439"},"modified":"2025-01-07T22:22:33","modified_gmt":"2025-01-07T15:22:33","slug":"pantoprazole-vintolox","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/","title":{"rendered":"Pantoprazole &#8211; Vintolox"},"content":{"rendered":"<p><em>Thu\u1ed1c Vintolox l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Vintolox (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;)<\/em><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_81 ez-toc-wrap-left counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">N\u1ed9i dung ch\u00ednh<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#1-ten-hoat-chat-va-biet-duoc\" >1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#2-dang-bao-che-%e2%80%93-ham-luong\" >2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#3-video-by-pharmog\" >3. Video by Pharmog:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#4-ung-dung-lam-sang\" >4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng:<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#41-chi-dinh\" >4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#42-lieu-dung-%e2%80%93-cach-dung\" >4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#43-chong-chi-dinh\" >4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#44-than-trong\" >4.4 Th\u1eadn tr\u1ecdng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#45-su-dung-cho-phu-nu-co-thai-va-cho-con-bu\" >4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#46-tac-dung-khong-mong-muon-adr\" >4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#47-huong-dan-cach-xu-tri-adr\" >4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#48-tuong-tac-voi-cac-thuoc-khac\" >4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#49-qua-lieu-va-xu-tri\" >4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#5-co-che-tac-dung-cua-thuoc\" >5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#51-duoc-luc-hoc\" >5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#52-duoc-dong-hoc\" >5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#53-giai-thich\" >5.3 Gi\u1ea3i th\u00edch:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#54-thay-the-thuoc\" >5.4 Thay th\u1ebf thu\u1ed1c :<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#6-phan-thong-tin-kem-theo-cua-thuoc\" >6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#61-danh-muc-ta-duoc\" >6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#62-tuong-ky\" >6.2. T\u01b0\u01a1ng k\u1ef5 :<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#63-bao-quan\" >6.3. B\u1ea3o qu\u1ea3n:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#64-thong-tin-khac\" >6.4. Th\u00f4ng tin kh\u00e1c :<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#65-tai-lieu-tham-khao\" >6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/pharmog.com\/wp\/pantoprazole-vintolox\/#7-nguoi-dang-tai-tac-gia\" >7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<\/a><\/li><\/ul><\/nav><\/div>\n\n<h1><span class=\"ez-toc-section\" id=\"1-ten-hoat-chat-va-biet-duoc\"><\/span>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <\/strong><a href=\"https:\/\/pharmog.com\/wp\/pantoprazole\/\"><strong>Pantoprazole<\/strong><\/a><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u00f4\u0301c \u01b0\u0301c ch\u00ea\u0301 b\u01a1m Proton. Thu\u1ed1c \u1ee9c ch\u1ebf ti\u1ebft acid d\u1ea1 d\u00e0y.<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): A02BC02.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em><\/strong> <a href=\"https:\/\/pharmog.com\/wp\/pantoprazole-pantoloc\/\">Pantoloc<\/a><\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c:<\/em><\/strong> Vintolox<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m V\u0129nh Ph\u00fac &#8211; Vi\u1ec7t Nam<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h1><span class=\"ez-toc-section\" id=\"2-dang-bao-che-%e2%80%93-ham-luong\"><\/span>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>Vi\u00ean n\u00e9n bao tan trong ru\u1ed9t: 40 mg.<\/p>\n<p>Thu\u1ed1c ti\u00eam b\u1ed9t \u0111\u00f4ng kh\u00f4: 40 mg.<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>VINTOLOX<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean bao tan trong ru\u1ed9t c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Pantoprazole<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>40 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"551\" height=\"349\" class=\"wp-image-42449\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2022\/02\/word-image-16.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2022\/02\/word-image-16.png 551w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2022\/02\/word-image-16-300x190.png 300w\" sizes=\"auto, (max-width: 551px) 100vw, 551px\" \/><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>VINTOLOX I.V<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i l\u1ecd b\u1ed9t pha ti\u00eam c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Pantoprazole<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>40 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"486\" height=\"418\" class=\"wp-image-42450\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2022\/02\/word-image-17.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2022\/02\/word-image-17.png 486w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2022\/02\/word-image-17-300x258.png 300w\" sizes=\"auto, (max-width: 486px) 100vw, 486px\" \/><\/p>\n<h1><span class=\"ez-toc-section\" id=\"3-video-by-pharmog\"><\/span>3. Video by Pharmog:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe loading=\"lazy\" title=\"[Pharmog SS1 - T\u1eadp 15] - D\u01b0\u1ee3c l\u00fd c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb vi\u00eam lo\u00e9t d\u1ea1 d\u00e0y t\u00e1 tr\u00e0ng\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/wgt47Xu6X-4?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<h1><span class=\"ez-toc-section\" id=\"4-ung-dung-lam-sang\"><\/span>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"41-chi-dinh\"><\/span>4.1. Ch\u1ec9 \u0111\u1ecbnh:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Lo\u00e9t d\u1ea1 d\u00e0y, t\u00e1 tr\u00e0ng.<\/p>\n<p>Tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y &#8211; th\u1ef1c qu\u1ea3n.<\/p>\n<p>H\u1ed9i ch\u1ee9ng Zollinger &#8211; Ellison.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"42-lieu-dung-%e2%80%93-cach-dung\"><\/span>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p><em>Vintolox vi\u00ean u\u1ed1ng:<\/em><\/p>\n<p>Thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng theo \u0111\u01b0\u1eddng u\u1ed1ng v\u00e0o bu\u1ed5i s\u00e1ng, tr\u01b0\u1edbc ho\u1eb7c sau \u0103n \u0111\u1ec1u \u0111\u01b0\u1ee3c. Khi u\u1ed1ng ph\u1ea3i nu\u1ed1t c\u1ea3 vi\u00ean, kh\u00f4ng \u0111\u01b0\u1ee3c b\u1ebb, nhai ho\u1eb7c l\u00e0m v\u1ee1 vi\u00ean thu\u1ed1c.<\/p>\n<p><em>Vintolox \u0111\u01b0\u1eddng ti\u00eam:<\/em><\/p>\n<p>Ch\u1ec9 d\u00f9ng thu\u1ed1c ti\u00eam b\u1ed9t \u0111\u00f4ng kh\u00f4 Vintolox khi kh\u00f4ng d\u00f9ng \u0111\u01b0\u1ee3c Pantoprazol \u0111\u01b0\u1eddng u\u1ed1ng.<\/p>\n<p>Chu\u1ea9n b\u1ecb ti\u00eam: D\u00f9ng b\u01a1m ti\u00eam v\u00f4 tr\u00f9ng h\u00fat h\u1ebft l\u01b0\u1ee3ng dung m\u00f4i trong \u1ed1ng dung m\u00f4i cho v\u00e0o l\u1ecd b\u1ed9t Vintolox, l\u1eafc \u0111\u1ec1u cho thu\u1ed1c tan ho\u00e0n to\u00e0n.<\/p>\n<p>Chuy\u1ec3n sang d\u00f9ng Pantoprazol d\u1ea1ng u\u1ed1ng ngay khi c\u00f3 c\u00e1c d\u1ea5u hi\u1ec7u l\u00e2m s\u00e0ng cho ph\u00e9p.<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p><em>*Vintolox vi\u00ean u\u1ed1ng:<\/em><\/p>\n<p>Ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em tr\u00ean 12 tu\u1ed5i:<\/p>\n<p><em>B\u1ec7nh tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y &#8211; th\u1ef1c qu\u1ea3n<\/em>: U\u1ed1ng 1 vi\u00ean\/ng\u00e0y, duy tr\u00ec trong 4 tu\u1ea7n, c\u00f3 th\u1ec3 k\u00e9o d\u00e0i \u0111\u1ebfn 8 tu\u1ea7n n\u1ebfu c\u1ea7n.<\/p>\n<p><em>Lo\u00e9t d\u1ea1 d\u00e0y, t\u00e1 tr\u00e0ng<\/em>: U\u1ed1ng 1 vi\u00ean\/ng\u00e0y trong 2 &#8211; 4 tu\u1ea7n \u0111\u1ed1i v\u1edbi lo\u00e9t t\u00e1 tr\u00e0ng v\u00e0 trong 4 &#8211; 8 tu\u1ea7n \u0111\u1ed1i v\u1edbi lo\u00e9t d\u1ea1 d\u00e0y.<\/p>\n<p>\u0110\u1ec3 di\u1ec7t tr\u1eeb Helicobacter pylori c\u00f3 th\u1ec3 k\u1ebft h\u1ee3p pantoprazol v\u1edbi 2 kh\u00e1ng sinh trong ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb 3 thu\u1ed1c trong 1 tu\u1ea7n. M\u1ed9t ph\u00e1c \u0111\u1ed3 hi\u1ec7u qu\u1ea3 g\u1ed3m pantoprazol 40 mg (1 vi\u00ean), 2 l\u1ea7n m\u1ed7i ng\u00e0y (u\u1ed1ng bu\u1ed5i s\u00e1ng v\u00e0 t\u1ed1i) ph\u1ed1i h\u1ee3p v\u1edbi clarithromycin 500 mg, ng\u00e0y 2 l\u1ea7n v\u00e0 amoxicilin 1 g, ng\u00e0y 2 l\u1ea7n ho\u1eb7c ph\u1ed1i h\u1ee3p clarithromycin 250 mg, ng\u00e0y 2 l\u1ea7n v\u00e0 metronidazol 400 mg, ng\u00e0y 2 l\u1ea7n.<\/p>\n<p><em>H\u1ed9i ch\u1ee9ng Zollinger &#8211; Ellison<\/em>: U\u1ed1ng li\u1ec1u kh\u1edfi \u0111\u1ea7u l\u00e0 80 mg (2 vi\u00ean) m\u1ed7i ng\u00e0y, sau \u0111\u00f3 \u0111i\u1ec1u ch\u1ec9nh theo \u0111\u00e1p \u1ee9ng c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh, c\u00f3 th\u1ec3 l\u00ean t\u1edbi 240 mg (6 vi\u00ean)\/ng\u00e0y. N\u1ebfu li\u1ec1u h\u00e0ng ng\u00e0y l\u1edbn h\u01a1n 80 mg (2 vi\u00ean) th\u00ec chia l\u00e0m 2 l\u1ea7n.<\/p>\n<p><em>Tr\u1ebb em d\u01b0\u1edbi 12 tu\u1ed5i:<\/em> Kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng \u1edf tr\u1ebb em d\u01b0\u1edbi 12 tu\u1ed5i do d\u1eef li\u1ec7u v\u1ec1 t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c tr\u00ean \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y c\u00f2n h\u1ea1n ch\u1ebf.<\/p>\n<p><em>Ng\u01b0\u1eddi cao tu\u1ed5i<\/em>: Kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u \u1edf \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y.<\/p>\n<p><em>B\u1ec7nh nh\u00e2n suy gan<\/em>: U\u1ed1ng 40 mg (1 vi\u00ean) c\u00e1ch 1 ng\u00e0y 1 l\u1ea7n. Kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng pantoprazol trong li\u1ec7u ph\u00e1p k\u1ebft h\u1ee3p \u0111\u1ec3 di\u1ec7t tr\u1eeb H. pylori \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n suy gan n\u1eb7ng v\u00ec hi\u1ec7n nay kh\u00f4ng c\u00f3 d\u1eef li\u1ec7u v\u1ec1 hi\u1ec7u qu\u1ea3 v\u00e0 \u0111\u1ed9 an to\u00e0n c\u1ee7a pantoprazol trong li\u1ec7u ph\u00e1p k\u1ebft h\u1ee3p cho nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y.<\/p>\n<p><em>B\u1ec7nh nh\u00e2n suy th\u1eadn<\/em>: Kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u \u1edf b\u1ec7nh nh\u00e2n suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn. Kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng pantoprazol trong li\u1ec7u ph\u00e1p k\u1ebft h\u1ee3p \u0111\u1ec3 di\u1ec7t tr\u1eeb H. pylori \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn v\u00ec hi\u1ec7n nay kh\u00f4ng c\u00f3 d\u1eef li\u1ec7u v\u1ec1 hi\u1ec7u qu\u1ea3 v\u00e0 \u0111\u1ed9 an to\u00e0n c\u1ee7a pantoprazol trong li\u1ec7u ph\u00e1p k\u1ebft h\u1ee3p cho nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y.<\/p>\n<p><em>*Vintolox \u0111\u01b0\u1eddng ti\u00eam:<\/em><\/p>\n<p>Lo\u00e9t d\u1ea1 d\u00e0y, t\u00e1 tr\u00e0ng; tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y \u2013 th\u1ef1c qu\u1ea3n: ti\u00eam t\u0129nh m\u1ea1ch trong th\u1eddi gian \u00edt nh\u1ea5t 2 ph\u00fat, m\u1ed7i ng\u00e0y m\u1ed9t l\u1ea7n 40mg<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb duy tr\u00ec H\u1ed9i ch\u1ee9ng Zollinger-Ellison v\u00e0 c\u00e1c tr\u01b0\u1eddng h\u1ee3p t\u0103ng b\u00e0i ti\u1ebft b\u1ec7nh l\u00fd: ng\u01b0\u1eddi b\u1ec7nh n\u00ean b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb v\u1edbi li\u1ec1u 80mg Pantoprazol\/ng\u00e0y, sau \u0111\u00f3 m\u1ed7i ng\u00e0y m\u1ed9t l\u1ea7n 80 mg, \u0111i\u1ec1u ch\u1ec9nh theo \u0111\u00e1p \u1ee9ng c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh, li\u1ec1u t\u1ed1i \u0111a 240 mg\/ ng\u00e0y. N\u1ebfu li\u1ec1u h\u00e0ng ng\u00e0y ng\u01b0\u1eddi l\u1edbn h\u01a1n 80 mg th\u00ec chia l\u00e0m 2 l\u1ea7n trong ng\u00e0y.<\/p>\n<p>Ph\u1ea3i gi\u1ea3m li\u1ec1u \u1edf ng\u01b0\u1eddi suy gan n\u1eb7ng ho\u1eb7c ph\u1ea3i d\u00f9ng c\u00e1ch ng\u00e0y: li\u1ec1u t\u1ed1i \u0111a m\u1ed7i ng\u00e0y 20 mg ho\u1eb7c hai ng\u00e0y d\u00f9ng m\u1ed9t l\u1ea7n 40 mg<\/p>\n<p>\u0110\u1ed1i v\u1edbi ng\u01b0\u1eddi suy th\u1eadn: th\u01b0\u1eddng kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u<\/p>\n<p>Tr\u1ebb em: \u0111\u1ed9 an to\u00e0n v\u00e0 hi\u1ec7u l\u1ef1c c\u1ee7a pantoprazol \u1edf tr\u1ebb em ch\u01b0a x\u00e1c \u0111\u1ecbnh.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"43-chong-chi-dinh\"><\/span>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Qu\u00e1 m\u1eabn v\u1edbi b\u1ea5t c\u1ee9 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p>S\u1eed d\u1ee5ng pantoprazol trong li\u1ec7u ph\u00e1p k\u1ebft h\u1ee3p \u0111\u1ec3 di\u1ec7t tr\u1eeb H. pylori \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn ho\u1eb7c suy gan n\u1eb7ng.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h2><span class=\"ez-toc-section\" id=\"44-than-trong\"><\/span>4.4 Th\u1eadn tr\u1ecdng:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Tr\u01b0\u1edbc khi d\u00f9ng pantoprazol ho\u1eb7c c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton kh\u00e1c, ph\u1ea3i lo\u1ea1i tr\u1eeb kh\u1ea3 n\u0103ng ung th\u01b0 d\u1ea1 d\u00e0y v\u00ec thu\u1ed1c c\u00f3 th\u1ec3 che l\u1ea5p tri\u1ec7u ch\u1ee9ng ho\u1eb7c l\u00e0m ch\u1eadm ch\u1ea9n \u0111o\u00e1n ung th\u01b0. Khi c\u00f3 b\u1ea5t k\u1ef3 tri\u1ec7u ch\u1ee9ng b\u00e1o \u0111\u1ed9ng n\u00e0o (v\u00ed d\u1ee5 nh\u01b0 gi\u1ea3m c\u00e2n, n\u00f4n m\u1eeda t\u00e1i ph\u00e1t, kh\u00f3 nu\u1ed1t, xu\u1ea5t huy\u1ebft, thi\u1ebfu m\u00e1u) v\u00e0 khi c\u00f3 nghi ng\u1edd ho\u1eb7c xu\u1ea5t hi\u1ec7n lo\u00e9t d\u1ea1 d\u00e0y, c\u1ea7n lo\u1ea1i tr\u1eeb u \u00e1c t\u00ednh.<\/p>\n<p>Ti\u1ebfp t\u1ee5c theo d\u00f5i n\u1ebfu c\u00e1c tri\u1ec7u ch\u1ee9ng v\u1eabn t\u1ed3n t\u1ea1i m\u1eb7c d\u00f9 \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb \u0111\u1ea7y \u0111\u1ee7.<\/p>\n<p>\u1ede b\u1ec7nh nh\u00e2n suy gan: C\u1ea7n xem x\u00e9t gi\u1ea3m li\u1ec1u pantoprazol ho\u1eb7c d\u00f9ng c\u00e1ch ng\u00e0y. C\u00f3 th\u1ec3 d\u00f9ng li\u1ec1u u\u1ed1ng 20 mg\/ng\u00e0y ho\u1eb7c u\u1ed1ng 40 mg, c\u00e1ch 1 ng\u00e0y 1 l\u1ea7n. Ph\u1ea3i theo d\u00f5i c\u00e1c enzym gan trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb. N\u1ebfu th\u1ea5y t\u0103ng, c\u1ea7n ng\u1eebng thu\u1ed1c.<\/p>\n<p>Trong li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb k\u1ebft h\u1ee3p, n\u00ean tu\u00e2n th\u1ee7 c\u00e1c \u0111\u1eb7c t\u00ednh c\u1ee7a c\u00e1c thu\u1ed1c trong li\u1ec7u ph\u00e1p.<\/p>\n<p>Kh\u00f4ng n\u00ean d\u00f9ng \u0111\u1ed3ng th\u1eddi atazanavir v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton (xem th\u00eam m\u1ee5c t\u01b0\u01a1ng t\u00e1c thu\u1ed1c).<\/p>\n<p><em>\u1ea2nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 h\u1ea5p thu vitamin B12:<\/em><\/p>\n<p>\u1ede nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 h\u1ed9i ch\u1ee9ng Zollinger &#8211; Ellison c\u1ea7n \u0111i\u1ec1u tr\u1ecb l\u00e2u d\u00e0i, pantoprazol c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m h\u1ea5p thu vitamin B12 (cyanocobalamin). V\u00ec v\u1eady ph\u1ea3i th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb k\u00e9o d\u00e0i pantoprazol \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 c\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1 g\u00e2y gi\u1ea3m h\u1ea5p thu vitamin B12 v\u00e0 theo d\u00f5i ch\u1eb7t ch\u1ebd nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y.<\/p>\n<p>Trong \u0111i\u1ec1u tr\u1ecb d\u00e0i ng\u00e0y, \u0111\u1eb7c bi\u1ec7t l\u00e0 khi th\u1eddi gian \u0111i\u1ec1u tr\u1ecb v\u01b0\u1ee3t qu\u00e1 1 n\u0103m, b\u1ec7nh nh\u00e2n n\u00ean \u0111\u01b0\u1ee3c theo d\u00f5i th\u01b0\u1eddng xuy\u00ean.<\/p>\n<p><em>Nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng ti\u00eau ho\u00e1 do vi khu\u1ea9n g\u00e2y ra<\/em>: Pantoprazol, gi\u1ed1ng nh\u01b0 t\u1ea5t c\u1ea3 c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf b\u01a1m proton (PPIs), c\u00f3 th\u1ec3 s\u1ebd l\u00e0m gia t\u0103ng s\u1ed1 l\u01b0\u1ee3ng vi khu\u1ea9n th\u01b0\u1eddng c\u00f3 trong \u0111\u01b0\u1eddng ti\u00eau h\u00f3a tr\u00ean. \u0110i\u1ec1u tr\u1ecb b\u1eb1ng pantoprazol c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng ti\u00eau h\u00f3a do vi khu\u1ea9n nh\u01b0 Salmonella v\u00e0 Campylobacter v\u00e0 C. difficile g\u00e2y ra.<\/p>\n<p><em>H\u1ea1 magnesi m\u00e1u<\/em>: H\u1ea1 magnesi m\u00e1u nghi\u00eam tr\u1ecdng \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c PPIs nh\u01b0 pantoprazol trong \u00edt nh\u1ea5t ba th\u00e1ng v\u00e0 h\u1ea7u h\u1ebft c\u00e1c tr\u01b0\u1eddng h\u1ee3p trong m\u1ed9t n\u0103m. C\u00e1c bi\u1ec3u hi\u1ec7n nghi\u00eam tr\u1ecdng c\u1ee7a h\u1ea1 magnesi m\u00e1u nh\u01b0 m\u1ec7t m\u1ecfi, \u0111au th\u1eaft l\u01b0ng, co gi\u1eadt, ch\u00f3ng m\u1eb7t v\u00e0 lo\u1ea1n nh\u1ecbp th\u1ea5t xu\u1ea5t hi\u1ec7n nh\u01b0ng c\u00f3 th\u1ec3 \u00e2m th\u1ea7m v\u00e0 b\u1ecb b\u1ecf qua. \u1ede nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb \u1ea3nh h\u01b0\u1edfng nh\u1ea5t, gi\u1ea3m magnesi m\u00e1u \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n sau khi b\u1ed5 sung magnesi v\u00e0 ng\u1eebng d\u00f9ng PPIs.<\/p>\n<p>\u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n d\u1ef1 ki\u1ebfn \u0111i\u1ec1u tr\u1ecb k\u00e9o d\u00e0i ho\u1eb7c d\u00f9ng PPIs c\u00f9ng v\u1edbi digoxin ho\u1eb7c c\u00e1c lo\u1ea1i thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y ra h\u1ea1 magnesi m\u00e1u (v\u00ed d\u1ee5, thu\u1ed1c l\u1ee3i ti\u1ec3u), n\u00ean xem x\u00e9t \u0111o n\u1ed3ng \u0111\u1ed9 magnesi tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb PPIs v\u00e0 \u0111\u1ecbnh k\u1ef3 trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p><em>G\u00e3y x\u01b0\u01a1ng:<\/em> Thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton, \u0111\u1eb7c bi\u1ec7t n\u1ebfu d\u00f9ng li\u1ec1u cao v\u00e0 trong th\u1eddi gian d\u00e0i (tr\u00ean 1 n\u0103m), c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 g\u00e3y x\u01b0\u01a1ng h\u00f4ng, c\u1ed5 tay v\u00e0 g\u00e3y c\u1ed9t s\u1ed1ng, ch\u1ee7 y\u1ebfu \u1edf ng\u01b0\u1eddi cao tu\u1ed5i ho\u1eb7c ng\u01b0\u1eddi c\u00f3 c\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1 kh\u00e1c. C\u00e1c nghi\u00ean c\u1ee9u theo d\u00f5i cho th\u1ea5y c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf b\u01a1m proton c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 g\u00e3y x\u01b0\u01a1ng l\u00ean 10 &#8211; 40%. M\u1ed9t s\u1ed1 gia t\u0103ng n\u00e0y c\u00f3 th\u1ec3 l\u00e0 do c\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1 kh\u00e1c. B\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 b\u1ecb lo\u00e3ng x\u01b0\u01a1ng n\u00ean \u0111\u01b0\u1ee3c ch\u0103m s\u00f3c theo h\u01b0\u1edbng d\u1eabn l\u00e2m s\u00e0ng v\u00e0 c\u1ea7n ph\u1ea3i u\u1ed1ng \u0111\u1ee7 l\u01b0\u1ee3ng vitamin D v\u00e0 calci.<\/p>\n<p><em>B\u1ec7nh lupus ban \u0111\u1ecf d\u01b0\u1edbi da (SCLE):<\/em> Thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton c\u00f3 li\u00ean quan \u0111\u1ebfn c\u00e1c tr\u01b0\u1eddng h\u1ee3p SCLE r\u1ea5t hi\u1ebfm. N\u1ebfu t\u1ed5n th\u01b0\u01a1ng x\u1ea3y ra, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u1edf v\u00f9ng da ti\u1ebfp x\u00fac v\u1edbi \u00e1nh n\u1eafng m\u1eb7t tr\u1eddi, v\u00e0 n\u1ebfu k\u00e8m theo \u0111au kh\u1edbp, c\u1ea7n ng\u1eebng d\u00f9ng pantoprazol ti\u00eam. Khi SCLE x\u1ea3y ra sau khi \u0111i\u1ec1u tr\u1ecb v\u1edbi pantoprazol c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 x\u1ea3y ra SCLE v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton kh\u00e1c.<\/p>\n<p>Trong c\u00f4ng th\u1ee9c c\u00f3 lactose, th\u1eadn tr\u1ecdng v\u1edbi b\u1ec7nh nh\u00e2n kh\u00f4ng dung n\u1ea1p galactose do di truy\u1ec1n, k\u00e9m h\u1ea5p thu glucose &#8211; galactose ho\u1eb7c thi\u1ebfu h\u1ee5t Lapp lactase.<\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>Thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y ch\u00f3ng m\u1eb7t, \u0111au \u0111\u1ea7u, nh\u00ecn m\u1edd. Do \u0111\u00f3, kh\u00f4ng n\u00ean l\u00e1i xe, v\u1eadn h\u00e0nh m\u00e1y m\u00f3c hay l\u00e0m vi\u1ec7c tr\u00ean cao khi g\u1eb7p c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n c\u1ee7a thu\u1ed1c.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"45-su-dung-cho-phu-nu-co-thai-va-cho-con-bu\"><\/span>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: B1<\/p>\n<p>US FDA pregnancy category: NA<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>Ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u \u0111\u1ea7y \u0111\u1ee7 khi d\u00f9ng pantoprazol \u1edf ng\u01b0\u1eddi trong th\u1eddi k\u1ef3 mang thai. Ch\u1ec9 d\u00f9ng pantoprazol cho ph\u1ee5 n\u1eef mang thai khi th\u1eadt c\u1ea7n thi\u1ebft.<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>Pantoprazol c\u00f3 b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9. C\u1ea7n c\u00e2n nh\u1eafc ng\u1eebng cho con b\u00fa hay ng\u1eebng thu\u1ed1c, t\u00f9y theo l\u1ee3i \u00edch c\u1ee7a pantoprazol v\u1edbi ng\u01b0\u1eddi m\u1eb9.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h2><span class=\"ez-toc-section\" id=\"46-tac-dung-khong-mong-muon-adr\"><\/span>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Nh\u00ecn chung, pantoprazol dung n\u1ea1p t\u1ed1t c\u1ea3 khi \u0111i\u1ec1u tr\u1ecb ng\u1eafn h\u1ea1n v\u00e0 d\u00e0i h\u1ea1n. C\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton l\u00e0m gi\u1ea3m \u0111\u1ed9 acid \u1edf d\u1ea1 d\u00e0y, c\u00f3 th\u1ec3 t\u0103ng nguy c\u01a1 nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/p>\n<p><em>Th\u01b0\u1eddng g\u1eb7p, ADR &gt; 1\/100<\/em><\/p>\n<p>To\u00e0n th\u00e2n: m\u1ec7t, ch\u00f3ng m\u1eb7t, \u0111au \u0111\u1ea7u.<\/p>\n<p>Da: Ban da, m\u00e0y \u0111ay.<\/p>\n<p>Ti\u00eau h\u00f3a: Kh\u00f4 mi\u1ec7ng, bu\u1ed3n n\u00f4n, n\u00f4n, \u0111\u1ea7y h\u01a1i, \u0111au b\u1ee5ng, t\u00e1o b\u00f3n, \u1ec9a ch\u1ea3y.<\/p>\n<p>C\u01a1 kh\u1edbp: \u0110au c\u01a1, \u0111au kh\u1edbp.<\/p>\n<p><em>\u00cdt g\u1eb7p, 1\/1000 &lt; ADR &lt; 1\/100<\/em><\/p>\n<p>To\u00e0n th\u00e2n: Suy nh\u01b0\u1ee3c, cho\u00e1ng v\u00e1ng, ch\u00f3ng m\u1eb7t, m\u1ea5t ng\u1ee7.<\/p>\n<p>Da: Ng\u1ee9a.<\/p>\n<p>Gan: T\u0103ng enzym gan.<\/p>\n<p><em>Hi\u1ebfm g\u1eb7p, ADR &lt; 1\/1000<\/em><\/p>\n<p>To\u00e0n th\u00e2n: To\u00e1t m\u1ed3 h\u00f4i, ph\u00f9 ngo\u1ea1i bi\u00ean, t\u00ecnh tr\u1ea1ng kh\u00f3 ch\u1ecbu, ph\u1ea3n v\u1ec7.<\/p>\n<p>Da: Ban d\u00e1t s\u1ea7n, tr\u1ee9ng c\u00e1, r\u1ee5ng t\u00f3c, vi\u00eam da tr\u00f3c v\u1ea3y, ph\u00f9 m\u1ea1ch, h\u1ed3ng ban \u0111a d\u1ea1ng.<\/p>\n<p>Ti\u00eau h\u00f3a: Vi\u00eam mi\u1ec7ng, \u1ee3 h\u01a1i, r\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a.<\/p>\n<p>M\u1eaft: Nh\u00ecn m\u1edd, ch\u1ee9ng s\u1ee3 \u00e1nh s\u00e1ng.<\/p>\n<p>Th\u1ea7n kinh: M\u1ea5t ng\u1ee7, ng\u1ee7 g\u00e0, t\u00ecnh tr\u1ea1ng k\u00edch \u0111\u1ed9ng ho\u1eb7c \u1ee9c ch\u1ebf, \u00f9 tai, run, nh\u1ea7m l\u1eabn, \u1ea3o gi\u00e1c, d\u1ecb c\u1ea3m.<\/p>\n<p>M\u00e1u: T\u0103ng b\u1ea1ch c\u1ea7u \u01b0a acid, m\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t, gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m ti\u1ec3u c\u1ea7u.<\/p>\n<p>N\u1ed9i ti\u1ebft: Li\u1ec7t d\u01b0\u01a1ng, b\u1ea5t l\u1ef1c \u1edf nam gi\u1edbi.<\/p>\n<p>Ti\u1ebft ni\u1ec7u: \u0110\u00e1i m\u00e1u, vi\u00eam th\u1eadn k\u1ebd.<\/p>\n<p>Gan: Vi\u00eam gan, v\u00e0ng da, b\u1ec7nh n\u00e3o \u1edf ng\u01b0\u1eddi suy gan, t\u0103ng triglycerit.<\/p>\n<p>R\u1ed1i lo\u1ea1n ion: Gi\u1ea3m natri m\u00e1u.<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<h2><span class=\"ez-toc-section\" id=\"47-huong-dan-cach-xu-tri-adr\"><\/span>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Pantoprazol th\u01b0\u1eddng dung n\u1ea1p t\u1ed1t: \u0110au b\u1ee5ng, \u1ec9a ch\u1ea3y, nh\u1ee9c \u0111\u1ea7u, m\u1ec7t m\u1ecfi th\u01b0\u1eddng h\u1ebft khi ti\u1ebfp t\u1ee5c \u0111i\u1ec1u tr\u1ecb, r\u1ea5t \u00edt khi ph\u1ea3i ng\u1eebng thu\u1ed1c. C\u1ea7n ph\u1ea3i theo d\u00f5i c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u01b0 nh\u00ecn m\u1edd, tr\u1ea7m c\u1ea3m, vi\u00eam da, \u0111\u00e1i ra m\u00e1u, ph\u00e1t ban, li\u1ec7t d\u01b0\u01a1ng&#8230; N\u1ebfu k\u00e9o d\u00e0i ph\u1ea3i ng\u1eebng thu\u1ed1c ho\u1eb7c chuy\u1ec3n sang thu\u1ed1c kh\u00e1c<\/p>\n<h2><span class=\"ez-toc-section\" id=\"48-tuong-tac-voi-cac-thuoc-khac\"><\/span>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>\u1ea2nh h\u01b0\u1edfng c\u1ee7a pantoprazol l\u00ean s\u1ef1 h\u1ea5p thu c\u00e1c thu\u1ed1c h\u1ea5p thu ph\u1ee5 thu\u1ed9c v\u00e0o pH:<\/em><\/p>\n<p>Do \u1ee9c ch\u1ebf ti\u1ebft acid c\u1ee7a d\u1ea1 d\u00e0y, pantoprazol c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m s\u1ef1 h\u1ea5p thu c\u00e1c thu\u1ed1c c\u00f3 sinh kh\u1ea3 d\u1ee5ng ph\u1ee5 thu\u1ed9c v\u00e0o pH \u1edf d\u1ea1 d\u00e0y, v\u00ed d\u1ee5 nh\u01b0 m\u1ed9t s\u1ed1 azol ch\u1ed1ng n\u1ea5m nh\u01b0 ketoconazol, itraconazol, posaconazol v\u00e0 c\u00e1c thu\u1ed1c kh\u00e1c nh\u01b0 erlotinib.<\/p>\n<p><em>Thu\u1ed1c \u1ee9c ch\u1ebf protease HIV (atazanavir):<\/em> Kh\u00f4ng n\u00ean d\u00f9ng ph\u1ed1i h\u1ee3p pantoprazol v\u1edbi c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf protease HIV m\u00e0 s\u1ef1 h\u1ea5p th\u1ee5 ph\u1ee5 thu\u1ed9c v\u00e0o \u0111\u1ed9 pH acid nh\u01b0 atazanavir do l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 sinh kh\u1ea3 d\u1ee5ng c\u1ee7a thu\u1ed1c.<\/p>\n<p>N\u1ebfu b\u1eaft bu\u1ed9c ph\u1ea3i k\u1ebft h\u1ee3p c\u00e1c thu\u1ed1c n\u00e0y, c\u1ea7n theo d\u00f5i l\u00e2m s\u00e0ng ch\u1eb7t ch\u1ebd k\u1ebft h\u1ee3p v\u1edbi t\u0103ng li\u1ec1u atazanavir l\u00ean \u0111\u1ebfn 400 mg (\u0111\u1ed3ng th\u1eddi v\u1edbi 100 mg ritonavir). Li\u1ec1u pantoprazol kh\u00f4ng \u0111\u01b0\u1ee3c v\u01b0\u1ee3t qu\u00e1 20 mg m\u1ed7i ng\u00e0y.<\/p>\n<p><em>Thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u coumarin (phenprocoumon ho\u1eb7c warfarin):<\/em><\/p>\n<p>S\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi pantoprazol v\u1edbi warfarin ho\u1eb7c phenprocoumon kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a warfarin, phenprocoumon. Tuy nhi\u00ean, \u0111\u00e3 c\u00f3 b\u00e1o c\u00e1o v\u1ec1 t\u0103ng INR v\u00e0 th\u1eddi gian prothrombin \u1edf b\u1ec7nh nh\u00e2n d\u00f9ng \u0111\u1ed3ng th\u1eddi PPIs v\u00e0 warfarin ho\u1eb7c phenprocoumon, c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn ch\u1ea3y m\u00e1u b\u1ea5t th\u01b0\u1eddng v\u00e0 th\u1eadm ch\u00ed t\u1eed vong. B\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb ph\u1ed1i h\u1ee3p pantoprazol v\u1edbi c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u coumarin (v\u00ed d\u1ee5 nh\u01b0 warfarin ho\u1eb7c phenprocoumon) c\u1ea7n \u0111\u01b0\u1ee3c theo d\u00f5i INR v\u00e0 th\u1eddi gian prothrombin.<\/p>\n<p><em>Methotrexat<\/em><\/p>\n<p>Vi\u1ec7c s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi methotrexat li\u1ec1u cao (v\u00ed d\u1ee5 nh\u01b0 300 mg) v\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf b\u01a1m proton \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o l\u00e0 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 methotrexat \u1edf m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n. Do \u0111\u00f3 khi s\u1eed d\u1ee5ng methotrexat li\u1ec1u cao, v\u00ed d\u1ee5 nh\u01b0 trong b\u1ec7nh ung th\u01b0 v\u00e0 b\u1ec7nh v\u1ea9y n\u1ebfn, c\u1ea7n ph\u1ea3i c\u00e2n nh\u1eafc vi\u1ec7c ng\u1eebng t\u1ea1m th\u1eddi pantoprazol.<\/p>\n<p><em>C\u00e1c nghi\u00ean c\u1ee9u t\u01b0\u01a1ng t\u00e1c kh\u00e1c:<\/em><\/p>\n<p>Pantoprazol chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu \u1edf gan b\u1edfi enzym cytochrom P450 CYP2C19 th\u00e0nh desmethylpantoprazol. M\u1ed9t ph\u1ea7n nh\u1ecf \u0111\u01b0\u1ee3c oxy h\u00f3a b\u1edfi CYP3A4.<\/p>\n<p>Kh\u00f4ng lo\u1ea1i tr\u1eeb c\u00f3 th\u1ec3 c\u00f3 t\u01b0\u01a1ng t\u00e1c v\u1edbi m\u1ed9t ch\u1ea5t kh\u00e1c c\u0169ng \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a qua ch\u00ednh h\u1ec7 th\u1ed1ng enzym n\u00e0y. Tuy nhi\u00ean, kh\u00f4ng c\u00f3 t\u01b0\u01a1ng t\u00e1c n\u00e0o c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng gi\u1eefa pantoprazol v\u1edbi c\u00e1c thu\u1ed1c nh\u01b0 carbamazepin, diazepam, glibenclamid, nifedipin, v\u00e0 thu\u1ed1c ng\u1eeba thai u\u1ed1ng c\u00f3 ch\u1ee9a levonorgestrel v\u00e0 ethinyl oestradiol.<\/p>\n<p>K\u1ebft qu\u1ea3 t\u1eeb m\u1ed9t lo\u1ea1t nghi\u00ean c\u1ee9u t\u01b0\u01a1ng t\u00e1c cho th\u1ea5y pantoprazol kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 chuy\u1ec3n h\u00f3a c\u1ee7a c\u00e1c ch\u1ea5t ho\u1ea1t t\u00ednh \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1edfi CYP1A2 (nh\u01b0 cafein, theophylin), CYP2C9 (nh\u01b0 piroxicam, diclofenac, naproxen), CYP2D6 (nh\u01b0 metoprolol), CYP2E1 (nh\u01b0 ethanol) ho\u1eb7c kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 h\u1ea5p thu digoxin li\u00ean quan t\u1edbi p &#8211; glycoprotein.<\/p>\n<p>Kh\u00f4ng c\u00f3 t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1ng acid khi d\u00f9ng \u0111\u1ed3ng th\u1eddi.<\/p>\n<p>C\u00e1c nghi\u00ean c\u1ee9u t\u01b0\u01a1ng t\u00e1c c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n b\u1eb1ng c\u00e1ch d\u00f9ng chung pantoprazol v\u1edbi c\u00e1c kh\u00e1ng sinh t\u01b0\u01a1ng \u1ee9ng (clarithromycin, metronidazol, amoxicilin). Kh\u00f4ng t\u00ecm th\u1ea5y t\u01b0\u01a1ng t\u00e1c c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"49-qua-lieu-va-xu-tri\"><\/span>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Qu\u00e1 li\u1ec1u: Kh\u00f4ng c\u00f3 tri\u1ec7u ch\u1ee9ng qu\u00e1 li\u1ec1u n\u00e0o \u0111\u01b0\u1ee3c bi\u1ebft \u1edf ng\u01b0\u1eddi.<\/p>\n<p>X\u1eed tr\u00ed: Kh\u00f4ng c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u. Ch\u1ee7 y\u1ebfu l\u00e0 \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng v\u00e0 h\u1ed7 tr\u1ee3. N\u1ebfu u\u1ed1ng qu\u00e1 li\u1ec1u c\u00f3 th\u1ec3 th\u1ef1c hi\u1ec7n g\u00e2y n\u00f4n, r\u1eeda d\u1ea1 d\u00e0y, d\u00f9ng than ho\u1ea1t. Theo d\u00f5i ho\u1ea1t \u0111\u1ed9ng c\u1ee7a tim, huy\u1ebft \u00e1p.<\/p>\n<p>Do pantoprazol g\u1eafn m\u1ea1nh v\u00e0o protein huy\u1ebft t\u01b0\u01a1ng, ph\u01b0\u01a1ng ph\u00e1p th\u1ea9m t\u00e1ch kh\u00f4ng lo\u1ea1i \u0111\u01b0\u1ee3c thu\u1ed1c.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h1><span class=\"ez-toc-section\" id=\"5-co-che-tac-dung-cua-thuoc\"><\/span>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"51-duoc-luc-hoc\"><\/span>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>M\u00e3 ATC: A02BC02<\/p>\n<p>Ch\u1ea5t \u1ee9c ch\u1ebf b\u01a1m proton.<\/p>\n<p>Pantoprazol khi v\u00e0o c\u00e1c \u1ed1ng ti\u1ebft acid c\u1ee7a t\u1ebf b\u00e0o th\u00e0nh d\u1ea1 d\u00e0y \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a th\u00e0nh ch\u1ea5t sulfenamid d\u1ea1ng c\u00f3 ho\u1ea1t t\u00ednh, d\u1ea1ng n\u00e0y li\u00ean k\u1ebft kh\u00f4ng thu\u1eadn ngh\u1ecbch v\u1edbi enzym H+\/K+-ATPase (c\u00f2n g\u1ecdi l\u00e0 b\u01a1m proton) c\u00f3 tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o th\u00e0nh d\u1ea1 d\u00e0y, g\u00e2y \u1ee9c ch\u1ebf enzym n\u00e0y, ng\u0103n c\u1ea3n b\u01b0\u1edbc cu\u1ed1i c\u00f9ng c\u1ee7a s\u1ef1 b\u00e0i ti\u1ebft acid d\u1ea1 d\u00e0y. V\u00ec v\u1eady pantoprazol c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf d\u1ea1 d\u00e0y ti\u1ebft acid c\u01a1 b\u1ea3n v\u00e0 c\u1ea3 khi d\u1ea1 d\u00e0y b\u1ecb k\u00edch th\u00edch do b\u1ea5t k\u1ef3 t\u00e1c nh\u00e2n k\u00edch th\u00edch n\u00e0o. T\u00e1c d\u1ee5ng c\u1ee7a pantoprazol ph\u1ee5 thu\u1ed9c v\u00e0o li\u1ec1u d\u00f9ng, th\u1eddi gian \u1ee9c ch\u1ebf b\u00e0i ti\u1ebft acid d\u1ecbch v\u1ecb k\u00e9o d\u00e0i h\u01a1n 24 gi\u1edd, m\u1eb7c d\u00f9 th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a pantoprazol ng\u1eafn h\u01a1n nhi\u1ec1u (0,7 &#8211; 1,9 gi\u1edd).<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>Pantoprazol l\u00e0 thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton, \u1ee9c ch\u1ebf giai \u0111o\u1ea1n cu\u1ed1i trong qu\u00e1 tr\u00ecnh t\u1ea1o th\u00e0nh acid \u1edf d\u1ea1 d\u00e0y b\u1eb1ng li\u00ean k\u1ebft d\u00f2ng h\u00f3a tr\u1ecb v\u1edbi h\u1ec7 men (H<sup>+<\/sup>, K<sup>+<\/sup>) &#8211; ATPase t\u1ea1i b\u1ec1 m\u1eb7t k\u00edch th\u00edch b\u00e0i ti\u1ebft c\u1ee7a t\u1ebf b\u00e0o th\u00e0nh d\u1ea1 d\u00e0y. C\u01a1 ch\u1ebf n\u00e0y d\u1eabn \u0111\u1ebfn \u1ee9c ch\u1ebf c\u1ea3 hai c\u01a1 ch\u1ebf ti\u1ebft acid d\u1ea1 d\u00e0y th\u00f4ng th\u01b0\u1eddng v\u00e0 do c\u00e1c t\u00e1c nh\u00e2n k\u00edch th\u00edch. S\u1ef1 g\u1eafn k\u1ebft v\u1edbi h\u1ec7 men (H<sup>+<\/sup>,K<sup>+<\/sup>) &#8211; ATPase s\u1ebd l\u00e0m t\u00e1c d\u1ee5ng kh\u00e1ng ti\u1ebft acid k\u00e9o d\u00e0i h\u01a1n 24 gi\u1edd.<\/p>\n<p><a href=\"https:\/\/www.youtube.com\/watch?v=wgt47Xu6X-4\"><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/a><\/p>\n<h2><span class=\"ez-toc-section\" id=\"52-duoc-dong-hoc\"><\/span>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Pantoprazol h\u1ea5p thu nhanh v\u00ec n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t cao nh\u1ea5t sau khi u\u1ed1ng kho\u1ea3ng 2 &#8211; 2,5 gi\u1edd. Thu\u1ed1c \u00edt b\u1ecb chuy\u1ec3n h\u00f3a b\u01b0\u1edbc m\u1ed9t \u1edf gan, sinh kh\u1ea3 d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng kho\u1ea3ng 70%. Kho\u1ea3ng 98% pantoprazol g\u1eafn v\u00e0o protein huy\u1ebft t\u01b0\u01a1ng. Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 kho\u1ea3ng 0,17 l\u00edt\/kg.<\/p>\n<p>Pantoprazol chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu \u1edf gan nh\u1edd isoenzym CYP2C19 c\u1ee7a cytochrom P450 \u0111\u1ec3 th\u00e0nh desmethylpantoprazol. M\u1ed9t ph\u1ea7n nh\u1ecf \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1edfi CYP3A4, CYP2D6, CYP2C9.<\/p>\n<p>C\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i ch\u1ee7 y\u1ebfu qua n\u01b0\u1edbc ti\u1ec3u (80%), ph\u1ea7n c\u00f2n l\u1ea1i qua m\u1eadt v\u00e0o ph\u00e2n.<\/p>\n<p>Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a pantoprazol kho\u1ea3ng 1 gi\u1edd v\u00e0 k\u00e9o d\u00e0i trong suy gan.<\/p>\n<p><em>\u0110\u1eb7c \u0111i\u1ec3m d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc \u1edf nh\u1eefng nh\u00f3m \u0111\u1ed1i t\u01b0\u1ee3ng \u0111\u1eb7c bi\u1ec7t:<\/em><\/p>\n<p>B\u1ec7nh nh\u00e2n thi\u1ebfu enzym CYP2C19, chuy\u1ec3n h\u00f3a thu\u1ed1c ch\u1ee7 y\u1ebfu l\u00e0 x\u00fac t\u00e1c b\u1edfi enzym CYP3A4. Sau m\u1ed9t li\u1ec1u duy nh\u1ea5t 40 mg pantoprazol, di\u1ec7n t\u00edch trung b\u00ecnh d\u01b0\u1edbi \u0111\u01b0\u1eddng cong cao h\u01a1n 6 l\u1ea7n so v\u1edbi ng\u01b0\u1eddi b\u00ecnh th\u01b0\u1eddng, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng t\u0103ng kho\u1ea3ng 60%. Tuy nhi\u00ean \u0111i\u1ec1u n\u00e0y kh\u00f4ng c\u00f3 \u00fd ngh\u0129a trong vi\u1ec7c x\u00e1c \u0111\u1ecbnh li\u1ec1u l\u01b0\u1ee3ng pantoprazol.<\/p>\n<p>B\u1ec7nh nh\u00e2n suy th\u1eadn: C\u0169ng nh\u01b0 \u0111\u1ed1i v\u1edbi ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh, th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a pantoprazol l\u00e0 ng\u1eafn v\u00e0 kh\u00f4ng c\u00f3 t\u00edch l\u0169y thu\u1ed1c. Do \u0111\u00f3, kh\u00f4ng c\u1ea7n gi\u1ea3m li\u1ec1u khi d\u00f9ng pantoprazol cho b\u1ec7nh nh\u00e2n suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn (bao g\u1ed3m c\u1ea3 b\u1ec7nh nh\u00e2n l\u1ecdc m\u00e1u).<\/p>\n<p>B\u1ec7nh nh\u00e2n x\u01a1 gan: Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a thu\u1ed1c \u1edf b\u1ec7nh nh\u00e2n x\u01a1 gan v\u00e0o kho\u1ea3ng 7-9 gi\u1edd, gi\u00e1 tr\u1ecb AUC t\u0103ng g\u1ea5p 5 &#8211; 7 l\u1ea7n, nh\u01b0ng n\u1ed3ng \u0111\u1ed9 t\u1ed1i \u0111a c\u1ee7a thu\u1ed1c trong huy\u1ebft thanh ch\u1ec9 t\u0103ng nh\u1eb9, g\u1ea5p 1,5 l\u1ea7n so v\u1edbi ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh.<\/p>\n<p>Ng\u01b0\u1eddi cao tu\u1ed5i: AUC v\u00e0 Cmax t\u0103ng nh\u1eb9 \u1edf nh\u1eefng ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n cao tu\u1ed5i so v\u1edbi nh\u1eefng ng\u01b0\u1eddi tr\u1ebb h\u01a1n nh\u01b0ng kh\u00f4ng c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng.<\/p>\n<p>Tr\u1ebb em: Sau khi u\u1ed1ng li\u1ec1u duy nh\u1ea5t 20 mg ho\u1eb7c 40 mg \u1edf tr\u1ebb em t\u1eeb 5 \u0111\u1ebfn 16 tu\u1ed5i, AUC v\u00e0 Cmax n\u1eb1m trong kho\u1ea3ng gi\u00e1 tr\u1ecb t\u01b0\u01a1ng \u1ee9ng \u1edf ng\u01b0\u1eddi l\u1edbn.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"53-giai-thich\"><\/span>5.3 Gi\u1ea3i th\u00edch:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"54-thay-the-thuoc\"><\/span>5.4 Thay th\u1ebf thu\u1ed1c :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h1><span class=\"ez-toc-section\" id=\"6-phan-thong-tin-kem-theo-cua-thuoc\"><\/span>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"61-danh-muc-ta-duoc\"><\/span>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Lactose, tinh b\u1ed9t ng\u00f4, avicel PH 101, magnesi stearat, talc, eudragit L-100, PEG 6000,PVP &#8211; K30, titan dioxyd, v\u00e0ng tartrazin<\/p>\n<h2><span class=\"ez-toc-section\" id=\"62-tuong-ky\"><\/span>6.2. T\u01b0\u01a1ng k\u1ef5 :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Kh\u00f4ng \u00e1p d\u1ee5ng.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"63-bao-quan\"><\/span>6.3. B\u1ea3o qu\u1ea3n:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>N\u01a1i kh\u00f4, tr\u00e1nh \u00e1nh s\u00e1ng, nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30\u00b0C.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"64-thong-tin-khac\"><\/span>6.4. Th\u00f4ng tin kh\u00e1c :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Kh\u00f4ng c\u00f3.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"65-tai-lieu-tham-khao\"><\/span>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>HDSD Thu\u1ed1c Vintolox do C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m V\u0129nh Ph\u00fac &#8211; Vi\u1ec7t Nam s\u1ea3n xu\u1ea5t (2018).<\/p>\n<h1><span class=\"ez-toc-section\" id=\"7-nguoi-dang-tai-tac-gia\"><\/span>7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p>B\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c s\u01b0u t\u1ea7m ho\u1eb7c vi\u1ebft b\u1edfi: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-tac-gia-bac-sy-do-my-linh\/\">B\u00e1c s\u0129 nhi khoa &#8211; \u0110\u1ed7 M\u1ef9 Linh.<\/a><\/p>\n<p>Ki\u1ec3m duy\u1ec7t , hi\u1ec7u \u0111\u00ednh v\u00e0 \u0111\u0103ng t\u1ea3i: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-ve-pharmog-team\/\">PHARMOG TEAM<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Vintolox l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Vintolox (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;) 1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Pantoprazole Ph\u00e2n lo\u1ea1i: Thu\u00f4\u0301c \u01b0\u0301c ch\u00ea\u0301 b\u01a1m Proton. [&hellip;]<\/p>\n","protected":false},"author":8612,"featured_media":42450,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[1681],"class_list":["post-42439","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-pantoprazole"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/42439","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/8612"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=42439"}],"version-history":[{"count":1,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/42439\/revisions"}],"predecessor-version":[{"id":42471,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/42439\/revisions\/42471"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/42450"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=42439"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=42439"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=42439"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}