{"id":42212,"date":"2022-01-28T15:33:04","date_gmt":"2022-01-28T08:33:04","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=42212"},"modified":"2025-01-07T22:33:54","modified_gmt":"2025-01-07T15:33:54","slug":"pregabalin-pendo-pregabalin","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/","title":{"rendered":"Pregabalin &#8211; pendo-Pregabalin"},"content":{"rendered":"<p><em>Thu\u1ed1c pendo-Pregabalin l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c pendo-Pregabalin (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;)<\/em><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_81 ez-toc-wrap-left counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">N\u1ed9i dung ch\u00ednh<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#1-ten-hoat-chat-va-biet-duoc\" >1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#2-dang-bao-che-%e2%80%93-ham-luong\" >2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#3-video-by-pharmog\" >3. Video by Pharmog:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#4-ung-dung-lam-sang\" >4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng:<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#41-chi-dinh\" >4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#42-lieu-dung-%e2%80%93-cach-dung\" >4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#43-chong-chi-dinh\" >4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#44-than-trong\" >4.4 Th\u1eadn tr\u1ecdng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#45-su-dung-cho-phu-nu-co-thai-va-cho-con-bu\" >4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#46-tac-dung-khong-mong-muon-adr\" >4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#47-huong-dan-cach-xu-tri-adr\" >4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#48-tuong-tac-voi-cac-thuoc-khac\" >4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#49-qua-lieu-va-xu-tri\" >4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#5-co-che-tac-dung-cua-thuoc\" >5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#51-duoc-luc-hoc\" >5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#52-duoc-dong-hoc\" >5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#53-giai-thich\" >5.3 Gi\u1ea3i th\u00edch:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#54-thay-the-thuoc\" >5.4 Thay th\u1ebf thu\u1ed1c :<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#6-phan-thong-tin-kem-theo-cua-thuoc\" >6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#61-danh-muc-ta-duoc\" >6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#62-tuong-ky\" >6.2. T\u01b0\u01a1ng k\u1ef5 :<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#63-bao-quan\" >6.3. B\u1ea3o qu\u1ea3n:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#64-thong-tin-khac\" >6.4. Th\u00f4ng tin kh\u00e1c :<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#65-tai-lieu-tham-khao\" >6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-pendo-pregabalin\/#7-nguoi-dang-tai-tac-gia\" >7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<\/a><\/li><\/ul><\/nav><\/div>\n\n<h1><span class=\"ez-toc-section\" id=\"1-ten-hoat-chat-va-biet-duoc\"><\/span>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <\/strong><a href=\"https:\/\/pharmog.com\/wp\/pregabaline\/\"><strong>Pregabalin (Pregabaline)<\/strong><\/a><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u1ed1c ch\u1ed1ng co gi\u1eadt, thu\u1ed1c gi\u1ea3m \u0111au.<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine).<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): N03AX16.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em><\/strong> <a href=\"https:\/\/pharmog.com\/wp\/pregabalin-lyrica\/\">Lyrica<\/a>.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c:<\/em><\/strong> pendo-Pregabalin<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: C\u00f4ng ty c\u1ed5 ph\u1ea7n xu\u1ea5t nh\u1eadp kh\u1ea9u y t\u1ebf Domesco<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h1><span class=\"ez-toc-section\" id=\"2-dang-bao-che-%e2%80%93-ham-luong\"><\/span>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>Vi\u00ean nang: 50 mg, 150 mg.<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>PENDO-PREGABALIN 50<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean nang c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Pregabaline<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>75 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"485\" height=\"387\" class=\"wp-image-42233\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2022\/01\/word-image-1057.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2022\/01\/word-image-1057.png 485w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2022\/01\/word-image-1057-300x239.png 300w\" sizes=\"auto, (max-width: 485px) 100vw, 485px\" \/><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>PENDO-PREGABALIN 150<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean nang c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Pregabaline<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>150 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"489\" height=\"400\" class=\"wp-image-42234\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2022\/01\/word-image-1058.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2022\/01\/word-image-1058.png 489w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2022\/01\/word-image-1058-300x245.png 300w\" sizes=\"auto, (max-width: 489px) 100vw, 489px\" \/><\/p>\n<h1><span class=\"ez-toc-section\" id=\"3-video-by-pharmog\"><\/span>3. Video by Pharmog:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<h1><span class=\"ez-toc-section\" id=\"4-ung-dung-lam-sang\"><\/span>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"41-chi-dinh\"><\/span>4.1. Ch\u1ec9 \u0111\u1ecbnh:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>\u0110i\u1ec1u tr\u1ecb \u0111au do nguy\u00ean nh\u00e2n th\u1ea7n kinh \u1edf ng\u01b0\u1eddi l\u1edbn:<\/em><\/p>\n<p>\u0110au d\u00e2y th\u1ea7n kinh ngo\u1ea1i vi \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng.<\/p>\n<p>\u0110au d\u00e2y th\u1ea7n kinh sau b\u1ec7nh Herpes.<\/p>\n<p>\u0110au d\u00e2y th\u1ea7n kinh do t\u1ed5n th\u01b0\u01a1ng t\u1ee7y s\u1ed1ng.<\/p>\n<p><em>\u0110i\u1ec1u tr\u1ecb \u0111au c\u01a1 do x\u01a1 h\u00f3a.<\/em><\/p>\n<h2><span class=\"ez-toc-section\" id=\"42-lieu-dung-%e2%80%93-cach-dung\"><\/span>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p>D\u00f9ng u\u1ed1ng, d\u00f9ng c\u00f9ng ho\u1eb7c kh\u00f4ng c\u00f9ng v\u1edbi th\u1ee9c \u0103n.<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p><em>\u0110au do nguy\u00ean nh\u00e2n th\u1ea7n kinh<\/em><\/p>\n<p>Li\u1ec1u kh\u1edfi \u0111\u1ea7u khuy\u1ebfn c\u00e1o l\u00e0 150 mg\/ng\u00e0y, u\u1ed1ng c\u00f9ng ho\u1eb7c kh\u00f4ng c\u00f9ng v\u1edbi th\u1ee9c \u0103n \u1edf b\u1ec7nh nh\u00e2n c\u00f3 \u0111\u1ed9 thanh th\u1ea3i creatinin \u00edt nh\u1ea5t 60 mL\/ph\u00fat. Hi\u1ec7u qu\u1ea3 c\u1ee7a pregabalin \u0111\u01b0\u1ee3c th\u1ea5y r\u00f5 trong tu\u1ea7n \u0111\u1ea7u ti\u00ean. T\u00f9y theo \u0111\u00e1p \u1ee9ng v\u00e0 dung n\u1ea1p thu\u1ed1c c\u1ee7a m\u1ed7i b\u1ec7nh nh\u00e2n, c\u00f3 th\u1ec3 t\u0103ng li\u1ec1u \u0111\u1ebfn 300 mg\/ng\u00e0y chia 2 l\u1ea7n, 150mg\/l\u1ea7n) sau m\u1ed9t tu\u1ea7n.<\/p>\n<p>B\u1ec7nh nh\u00e2n \u0111au li\u00ean t\u1ee5c, \u0111\u00e1ng k\u1ec3 v\u00e0 c\u00f3 \u0111\u00e1p \u1ee9ng t\u1ed1t v\u1edbi li\u1ec1u 300 mg\/ng\u00e0y, c\u00f3 th\u1ec3 d\u00f9ng li\u1ec1u t\u1ed1i \u0111a 600 mg\/ng\u00e0y chia 2 l\u1ea7n, 300 mg\/l\u1ea7n). Tuy nhi\u00ean, trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng, hi\u1ec7u qu\u1ea3 c\u1ee7a pregabalin 600 mg\/ng\u00e0y t\u0103ng kh\u00f4ng c\u00f3 \u00fd ngh\u0129a v\u00e0 b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb v\u1edbi li\u1ec1u n\u00e0y c\u00f3 t\u1ef7 l\u1ec7 ph\u1ea3n \u1ee9ng kh\u00f4ng mong mu\u1ed1n cao h\u01a1n \u0111\u00e1ng k\u1ec3 v\u00e0 ng\u1eebng thu\u1ed1c nhi\u1ec1u h\u01a1n. Li\u1ec1u tr\u00ean 600 mg\/ng\u00e0y ch\u01b0a \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u00e0 kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng.<\/p>\n<p><em>\u0110au c\u01a1 do x\u01a1 h\u00f3a<\/em><\/p>\n<p>Li\u1ec1u khuy\u1ebfn c\u00e1o l\u00e0 300 \u2013 450 mg\/ng\u00e0y, chia 2 l\u1ea7n u\u1ed1ng. Li\u1ec1u kh\u1edfi \u0111\u1ea7u khuy\u1ebfn c\u00e1o l\u00e0 150 mg\/ng\u00e0y, u\u1ed1ng c\u00f9ng ho\u1eb7c kh\u00f4ng c\u00f9ng v\u1edbi th\u1ee9c \u0103n \u1edf b\u1ec7nh nh\u00e2n c\u00f3 \u0111\u1ed9 thanh th\u1ea3i creatinin \u00edt nh\u1ea5t 60 mL\/ph\u00fat. T\u00f9y theo \u0111\u00e1p \u1ee9ng v\u00e0 dung n\u1ea1p thu\u1ed1c c\u1ee7a m\u1ed7i b\u1ec7nh nh\u00e2n, c\u00f3 th\u1ec3 t\u0103ng li\u1ec1u \u0111\u1ebfn 300mg ng\u00e0y chia 2 l\u1ea7n, 150mg\/l\u1ea7n) sau m\u1ed9t tu\u1ea7n. B\u1ec7nh nh\u00e2n kh\u00f4ng \u0111\u00e1p \u1ee9ng \u0111\u1ea7y \u0111\u1ee7 v\u1edbi li\u1ec1u 300 mg\/ng\u00e0y c\u00f3 th\u1ec3 t\u0103ng li\u1ec1u l\u00ean 450 mg\/ng\u00e0y, chia 2 l\u1ea7n u\u1ed1ng. Hi\u1ec7u qu\u1ea3 c\u1ee7a pregabalin \u0111\u01b0\u1ee3c th\u1ea5y r\u00f5 trong tu\u1ea7n \u0111\u1ea7u ti\u00ean,<\/p>\n<p>B\u1ec7nh nh\u00e2n \u0111au li\u00ean t\u1ee5c, \u0111\u00e1ng k\u1ec3 v\u00e0 c\u00f3 \u0111\u00e1p \u1ee9ng t\u1ed1t v\u1edbi li\u1ec1u 300 mg\/ng\u00e0y, c\u00f3 th\u1ec3 d\u00f9ng li\u1ec1u t\u1ed1i \u0111a 600 mg\/ng\u00e0y (chia 2 l\u1ea7n, 300 mg\/l\u1ea7n). Tuy nhi\u00ean, trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng, hi\u1ec7u qu\u1ea3 c\u1ee7a pregabalin 600mg\/ng\u00e0y t\u0103ng kh\u00f4ng c\u00f3 \u00fd ngh\u0129a v\u00e0 b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb v\u1edbi li\u1ec1u n\u00e0y c\u00f3 t\u1ef7 l\u1ec7 ph\u1ea3n \u1ee9ng kh\u00f4ng mong mu\u1ed1n cao h\u01a1n \u0111\u00e1ng k\u1ec3 v\u00e0 ng\u1eebng thu\u1ed1c nhi\u1ec1u h\u01a1n. Vi c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 li\u00ean quan \u0111\u1ebfn li\u1ec1u d\u00f9ng, quy\u1ebft \u0111\u1ecbnh t\u0103ng li\u1ec1u tr\u00ean 450 mg\/ng\u00e0y ph\u1ea3i d\u1ef1a tr\u00ean \u0111\u00e1nh gi\u00e1 l\u00e2m s\u00e0ng c\u1ee7a b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb. Li\u1ec7u tr\u00ean 600 mg\/ng\u00e0y ch\u01b0a \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u00e0 kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng.<\/p>\n<p>Theo c\u00e1c th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng hi\u1ec7n t\u1ea1i, n\u1ebfu ng\u1eebng \u0111i\u1ec1u tr\u1ecb pregabalin, c\u1ea7n ng\u1eebng t\u1eeb t\u1eeb trong \u00edt nh\u1ea5t l\u00e0\/ng\u00e0y.<\/p>\n<p><em>\u0110i\u1ec1u ch\u1ec9nh li\u1ec1u theo ch\u1ee9c n\u0103ng th\u1eadn<\/em><\/p>\n<p>Pregabalin \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu qua th\u1eadn. Do \u0111\u00f3, c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u theo m\u1ee9c \u0111\u1ed9 suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn c\u1ee7a b\u1ec7nh nh\u00e2n. Thanh th\u1ea3i cregabalin t\u1ef7 l\u1ec7 thu\u1eadn v\u1edbi thanh th\u1ea3i creatinin. V\u00ec v\u1eady, \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u ph\u1ea3i d\u1ef1a tr\u00ean \u0111\u1ed9 thanh th\u1ea3i creatinin (CLcr) \u0111\u01b0\u1ee3c tr\u00ecnh b\u00e0y trong b\u1ea3ng sau.<\/p>\n<p>C\u00f3 th\u1ec3 d\u00f9ng C\u00f4ng th\u1ee9c Cockcroft v\u00e0 Gault d\u01b0\u1edbi \u0111\u00e2y \u0111\u1ec3 \u01b0\u1edbc t\u00ednh \u0111\u1ed9 thanh th\u1ea3i creatinin c\u1ee7a b\u1ec7nh nh\u00e2n (ml\/ph\u00fat).<\/p>\n<p>ClCr (mL\/ph\u00fat) = [1,23 x (140 &#8211; tu\u1ed5i) x c\u00e2n n\u1eb7ng (kg)]\/creatinin huy\u1ebft thanh (\u03bcmol\/L) (x 0,85 \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n n\u1eef)<\/p>\n<p>Pregabalin \u0111\u01b0\u1ee3c lo\u1ea1i b\u1ecf hi\u1ec7u qu\u1ea3 kh\u1ecfi huy\u1ebft t\u01b0\u01a1ng nh\u1edd th\u1ea9m t\u00e1ch m\u00e1u. Sau 4 gi\u1edd th\u1ea9m t\u00e1ch, n\u1ed3ng \u0111\u1ed9 pregabalin gi\u1ea3m kho\u1ea3ng 50%. V\u1edbi c\u00e1c b\u1ec7nh nh\u00e2n \u0111ang l\u00e0m th\u1ea9m t\u00e1ch m\u00e1u, li\u1ec1u h\u00e0ng ng\u00e0y c\u1ee7a pregabalin c\u1ea7n \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh t\u00f9y theo ch\u1ee9c n\u0103ng suy th\u1eadn. B\u00ean c\u1ea1nh li\u1ec1u d\u00f9ng h\u1eb1ng ng\u00e0y, li\u1ec1u d\u00f9ng b\u1ed5 sung n\u00ean \u0111\u01b0\u1ee3c d\u00f9ng ngay sau m\u1ed7i 4 gi\u1edd th\u1ea9m t\u00e1ch m\u00e1u.<\/p>\n<p>B\u1ea3ng 1.\u0110i\u1ec1u ch\u1ec9nh li\u1ec1u pregabalin theo ch\u1ee9c n\u0103ng th\u1eadn<\/p>\n<table>\n<tbody>\n<tr>\n<td rowspan=\"2\"><strong>\u0110\u1ed9 thanh th\u1ea3i Creatinin<\/strong><\/p>\n<p><strong>(Clcr)(ml\/ph\u00fat)<\/strong><\/td>\n<td colspan=\"4\"><strong>T\u1ed5ng li\u1ec1u pregabalin h\u00e0ng ng\u00e0y (mg\/ng\u00e0y)*<\/strong><\/p>\n<p><strong>Khuy\u1ebfn c\u00e1o t\u0103ng li\u1ec1u**<\/strong><\/td>\n<td rowspan=\"2\"><strong>Ch\u1ebf \u0111\u1ed9 tr\u1ecb li\u1ec7u<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>Li\u1ec1u kh\u1edfi \u0111\u1ea7u<\/strong><\/td>\n<td colspan=\"2\"><strong>T\u0103ng li\u1ec1u<\/strong><\/td>\n<td><strong>Li\u1ec1u t\u1ed1i \u0111a<\/strong><\/td>\n<\/tr>\n<tr>\n<td>\u2265 60<\/td>\n<td>150<\/td>\n<td>300<\/td>\n<td>450<\/td>\n<td>600<\/td>\n<td>2 hay 3 l\u1ea7n\/ng\u00e0y<\/td>\n<\/tr>\n<tr>\n<td>30\u201360<\/td>\n<td>75<\/td>\n<td>150<\/td>\n<td>225<\/td>\n<td>300<\/td>\n<td>2 hay 3 l\u1ea7n\/ng\u00e0y<\/td>\n<\/tr>\n<tr>\n<td>15\u201330<\/td>\n<td>25\u201350<\/td>\n<td>75<\/td>\n<td>100\u2013150<\/td>\n<td>150<\/td>\n<td>1 hay 2 l\u1ea7n\/ng\u00e0y<\/td>\n<\/tr>\n<tr>\n<td>&lt;15<\/td>\n<td>25<\/td>\n<td>25\u201350<\/td>\n<td>50\u201375<\/td>\n<td>75<\/td>\n<td>1 l\u1ea7n\/ng\u00e0y<\/td>\n<\/tr>\n<tr>\n<td colspan=\"6\">Li\u1ec1u b\u1ed5 sung sau khi th\u1ea9m t\u00e1ch m\u00e1u (mg)+<\/p>\n<p>B\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng 25mg ch\u1ebf \u0111\u1ed9 tr\u1ecb li\u1ec7u 1 l\u1ea7n\/ng\u00e0y: B\u1ed5 sung 1 li\u1ec1u 25mg ho\u1eb7c 50mg<\/p>\n<p>B\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng 25-50mg ch\u1ebf \u0111\u1ed9 tr\u1ecb li\u1ec7u 1 l\u1ea7n\/ng\u00e0y: B\u1ed5 sung 1 li\u1ec1u 50mg ho\u1eb7c75mg<\/p>\n<p>B\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng 50-75mg ch\u1ebf \u0111\u1ed9 tr\u1ecb li\u1ec7u1 l\u1ea7nng\u00e0y: B\u1ed5 sung 1 li\u1ec1u 75mg ho\u1eb7c 100 mg<\/p>\n<p>B\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng 75 mg ch\u1ebf \u0111\u1ed9 tr\u1ecb li\u1ec7u 1 l\u1ea7n\/ng\u00e0y: B\u1ed5 sung 1 li\u1ec1u 100 mg ho\u1eb7c 150mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>**T\u00f9y theo \u0111\u00e1p \u1ee9ng v\u00e0 dung n\u1ea1p c\u1ee7a m\u1ed7i b\u1ec7nh nh\u00e2n<\/p>\n<p>*T\u1ed5ng li\u1ec1u d\u00f9ng h\u00e0ng ng\u00e0y(mg\/ng\u00e0y) ph\u1ea3i \u0111\u01b0\u1ee3c chia theo ch\u1ec9 \u0111\u1ecbnh.<\/p>\n<p>+Li\u1ec1u b\u1ed5 sung l\u00e0 li\u1ec1u \u0111\u01a1n.<\/p>\n<p><em>B\u1ec7nh nh\u00e2n tr\u00ean 65 tu\u1ed5i<\/em><\/p>\n<p>Kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u v\u1edbi ng\u01b0\u1eddi gi\u00e0 tr\u1eeb trong tr\u01b0\u1eddng h\u1ee3p t\u1ed5n th\u01b0\u01a1ng ch\u1ee9c n\u0103ng th\u1eadn.<\/p>\n<p><em>Tr\u1ebb em (&lt;18 tu\u1ed5i):<\/em><\/p>\n<p>Kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng pregabalin \u1edf b\u1ec7nh nh\u00e2n nh\u1ecf h\u01a1n 18 tu\u1ed5i v\u00e0 ch\u01b0a c\u00f3 th\u00f4ng tin v\u1ec1 t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c tr\u00ean nh\u00f3m tu\u1ed5i n\u00e0y.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"43-chong-chi-dinh\"><\/span>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>M\u1eabn c\u1ea3m v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h2><span class=\"ez-toc-section\" id=\"44-than-trong\"><\/span>4.4 Th\u1eadn tr\u1ecdng:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>T\u0103ng tr\u1ecdng l\u01b0\u1ee3ng c\u01a1 th\u1ec3<\/em><\/p>\n<p>Khi d\u00f9ng ph\u1ed1i h\u1ee3p pregabalin v\u1edbi thiazolidinedione (thu\u1ed1c ch\u1ed1ng \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng c\u00f3 nguy cot\u0103ng tr\u1ecdng l\u01b0\u1ee3ng c\u01a1 th\u1ec3 v\u00e0 ph\u1ee5cao h\u01a1n so v\u1edbi khi d\u00f9ng pregabalin \u0111\u01a1n \u0111\u1ed9c.<\/p>\n<p>Pregabalin g\u00e2y t\u0103ng tr\u1ecdng l\u01b0\u1ee3ng c\u01a1 th\u1ec3 li\u00ean quan \u0111\u1ebfn li\u1ec1u v\u00e0 th\u1eddi gian d\u00f9ng thu\u1ed1c, tuy nhi\u00ean, t\u0103ng c\u00e2n kh\u00f4ng li\u00ean quan \u0111\u1ebfn ch\u1ec9 s\u1ed1 kh\u1ed1i l\u01b0\u1ee3ng c\u01a1 th\u1ec3 (BMI) tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb, gi\u1edbi t\u00ednh, ho\u1eb7c tu\u1ed5i, v\u00e0 c\u0169ng kh\u00f4ng do ph\u1ee7. Tuy trong nghi\u00ean c\u1ee9u ng\u1eafn h\u1ea1n c\u00f3 ki\u1ec3m so\u00e1t, t\u0103ng c\u00e2n kh\u00f4ng k\u1ebft h\u1ee3p v\u1edbi bi\u1ebfn \u0111\u1ed5i l\u00e2m s\u00e0ng quan tr\u1ecdng v\u1ec1 huy\u1ebft \u00e1p, nh\u01b0ng l\u00e2u d\u00e0i v\u1ec1 tim m\u1ea1ch ch\u01b0a \u0111\u01b0\u1ee3c l\u00e0m r\u00f5.Ngo\u00e0i ra, Pregabalin kh\u00f4ng l\u00e0m m\u1ea5t ki\u1ec3m so\u00e1t glucose huy\u1ebft.<\/p>\n<p><em>Ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn<\/em><\/p>\n<p>\u0110\u00e3 c\u00f3 b\u00e1o c\u00e1o sau khi thu\u1ed1c l\u01b0u h\u00e0nh tr\u00ean th\u1ecb tr\u01b0\u1eddng v\u1ec1 c\u00e1c ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn, k\u1ec3 c\u1ea3 ph\u00f9 m\u1ea1ch. Ph\u1ea3i ng\u1eebng pregabalin ngay l\u1eadp t\u1ee9c n\u1ebfu c\u00f3 tri\u1ec7u ch\u1ee9ng ph\u00f9 m\u1ea1ch nh\u01b0 ph\u00f9 m\u1eb7t, s\u01b0ng quanh mi\u1ec7ng, s\u01b0ng \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p tr\u00ean.<\/p>\n<p>C\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng pregabalin \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed b\u1ecb ph\u00f9 m\u1ea1ch v\u00e0 c\u00e1c bi\u1ebfn c\u1ed1 li\u00ean quan. Ngo\u00e0i ra, b\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng thu\u1ed1c kh\u00e1c li\u00ean quan \u0111\u1ebfn ph\u00f9 m\u1ea1ch nh\u01b0 c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf men chuy\u1ec3n angiotensin (ACE) c\u00f3 th\u1ec3 t\u0103ng nguy c\u01a1 ph\u00e1t tri\u1ec3n t\u00ecnh tr\u1ea1ng n\u00e0y.<\/p>\n<p><em>Thu\u1ed1c \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn th\u1ea7n kinh trung \u01b0\u01a1ng<\/em><\/p>\n<p>Bu\u1ed3n ng\u1ee7, ch\u00f3ng m\u1eb7t c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m c\u1ea3 th\u1ec3 ch\u1ea5t v\u00e0 tinh th\u1ea7n c\u1ee7a b\u1ec7nh nh\u00e2n, do \u0111\u00f3 c\u1ea7n th\u1eadn tr\u1ecdng tr\u00ean nh\u1eefng \u0111\u1ed1i t\u01b0\u1ee3ng l\u00e1i xe ho\u1eb7c v\u1eadn h\u00e0nh m\u00e1y.<\/p>\n<p><em>\u1ea2nh h\u01b0\u1edfng tr\u00ean m\u1eaft<\/em><\/p>\n<p>Trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng c\u00f3 ki\u1ec3m ch\u1ee9ng, t\u1ef7 l\u1ec7 b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb v\u1edbi pregabalin b\u1ecb nh\u00ecn m\u1edd cao h\u01a1n b\u1ec7nh nh\u00e2n d\u00f9ng gi\u1ea3 d\u01b0\u1ee3c. Trong c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng c\u00f3 th\u1ef1c hi\u1ec7n ki\u1ec3m tra th\u1ecb l\u1ef1c, t\u1ef7 l\u1ec7 gi\u1ea3m th\u1ecb l\u1ef1c v\u00e0 thay \u0111\u1ed5i th\u1ecb tr\u01b0\u1eddng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng pregabalin l\u1edbn h\u01a1n \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n d\u00f9ng gi\u1ea3 d\u01b0\u1ee3c.<\/p>\n<p>C\u0169ng \u0111\u00e3 c\u00f3 b\u00e1o c\u00e1o ph\u1ea3n \u1ee9ng ph\u1ee5 tr\u00ean m\u1eb7t sau khi thu\u1ed1c l\u01b0u h\u00e0nh, bao g\u1ed3m m\u1ea5t th\u1ecb l\u1ef1c, nh\u00ecn m\u1edd hay thay \u0111\u1ed5i th\u1ecb tr\u01b0\u1eddng, ph\u1ea7n nhi\u1ec1u ph\u1ea3n \u1ee9ng ph\u1ee5 trong s\u1ed1 \u0111\u00f3 l\u00e0 tho\u00e1ng qua.<\/p>\n<p>Ng\u1eebng pregabalin c\u00f3 th\u1ec3 gi\u1ea3i quy\u1ebft ho\u1eb7c c\u1ea3i thi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng v\u1ec1 th\u1ecb gi\u00e1c n\u00e0y.<\/p>\n<p><em>Suy th\u1eadn<\/em><\/p>\n<p>\u0110\u00e3 c\u00f3 b\u00e1o c\u00e1o v\u1ec1 c\u00e1c tr\u01b0\u1eddng h\u1ee3p suy th\u1eadn v\u00e0 trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p ng\u1eebng pregabalin \u0111\u00e3 cho th\u1ea5y \u0111\u1ea3o ng\u01b0\u1ee3c ph\u1ea3n \u1ee9ng ph\u1ee5 n\u00e0y.<\/p>\n<p><em>Ng\u1eebng thu\u1ed1c nhanhh<\/em><\/p>\n<p>Sau khi ng\u1eebng s\u1eed d\u1ee5ng pregabalin nhanh hay \u0111\u1ed9t ng\u1ed9t, m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n \u0111\u00e3 b\u00e1o c\u00e1o c\u00e1c tri\u1ec7u ch\u1ee9ng bao g\u1ed3m m\u1ea5t ng\u1ee7, bu\u1ed3n n\u00f4n, nh\u1ee9c \u0111\u1ea7u, lo l\u1eafng, t\u0103ng ti\u1ebft m\u1ed3 h\u00f4i v\u00e0 ti\u00eau ch\u1ea3y.<\/p>\n<p>N\u00ean gi\u1ea3m li\u1ec1u pregabalin t\u1eeb t\u1eeb trong \u00edt nh\u1ea5t 7 ng\u00e0y, kh\u00f4ng ng\u01b0ng \u0111\u1ed9t ng\u1ed9t.<\/p>\n<p>Co gi\u1eadt, bao g\u1ed3m c\u01a1n \u0111\u1ed9ng kinh li\u00ean t\u1ee5c hay c\u01a1n \u0111\u1ed9ng kinh C\u01a1n l\u1edbn \u0111\u00e3 x\u1ea3y ra tr\u00ean b\u1ec7nh nh\u00e2n kh\u00f4ng b\u1ecb \u0111\u1ed9ng kinh trong khi \u0111i\u1ec1u tr\u1ecb v\u1edbi pregabalin ho\u1eb7c ngay sau khi ng\u1eebng d\u00f9ng pregabalin.<\/p>\n<p><em>Suy tim sung huy\u1ebft<\/em><\/p>\n<p>\u0110\u00e3 c\u00f3 b\u00e1o c\u00e1o sau khi thu\u1ed1c l\u01b0u h\u00e0nh v\u1ec1 suy tim sung huy\u1ebft tr\u00ean m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n d\u00f9ng Pregabalin. Nh\u1eefng ph\u1ea3n \u1ee9ng n\u00e0y ch\u1ee7 y\u1ebfu g\u1eb7p \u1edf b\u1ec7nh nh\u00e2n l\u1edbn tu\u1ed5i b\u1ecb b\u1ec7nh l\u00fd tim m\u1ea1ch ph\u1ee9c t\u1ea1p trong khi d\u00f9ng Pregabalin \u0111i\u1ec1u tr\u1ecb \u0111au d\u00e2y th\u1ea7n kinh. C\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng pregabalin \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y. Ng\u1eebng pregabalin c\u00f3 th\u1ec3 gi\u1ea3i quy\u1ebft c\u00e1c ph\u1ea3n \u1ee9ng.<\/p>\n<p><em>\u00dd t\u01b0\u1edfng v\u00e0 h\u00e0nh vi t\u1ef1 t\u1eed.<\/em><\/p>\n<p>\u0110\u00e3 c\u00f3 b\u00e1o c\u00e1o sau khi thu\u1ed1c l\u01b0u h\u00e0nh tr\u00ean th\u1ecb tr\u01b0\u1eddng v\u1ec1 c\u00e1c bi\u1ebfn c\u1ed1 li\u00ean quan \u0111\u1ebfn t\u1ef1 t\u1eed, bao g\u1ed3m t\u1ef1 t\u1eed, c\u1ed1 g\u1eafng t\u1ef1 t\u1eed v\u00e0 c\u00f3 \u00fd \u0111\u1ecbnh t\u1ef1 t\u1eed \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb v\u1edbi pregabalin cho c\u00e1c ch\u1ec9 \u0111\u1ecbnh kh\u00e1c nhau nh\u01b0 \u0111au d\u00e2y th\u1ea7n kinh, \u0111au c\u01a1,vv&#8230; M\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p trong c\u00e1c b\u00e1o c\u00e1o n\u00e0y c\u00f3 th\u1ec3 do c\u00e1c r\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n m\u1eafc s\u1eb5n g\u00f3p ph\u1ea7n cho bi\u1ebfn c\u1ed1 n\u00e0y. C\u01a1 ch\u1ebf v\u1ec1 nguy c\u01a1 n\u00e0y ch\u01b0a \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn, B\u1ec7nh nh\u00e2n c\u1ea7n \u0111\u01b0\u1ee3c theo d\u00f5i c\u00e1c d\u1ea5u hi\u1ec7u c\u1ee7a \u00fd t\u01b0\u1edfng v\u00e0 h\u00e0nh vi t\u1ef1 t\u1eed v\u00e0 xem x\u00e9t c\u00e1c bi\u1ec7n ph\u00e1p \u0111i\u1ec1u tr\u1ecb th\u00edch h\u1ee3p. B\u1ec7nh nh\u00e2n ph\u1ea3i \u0111\u01b0\u1ee3c khuy\u1ebfn kh\u00edch n\u00f3i l\u00ean b\u1ea5t c\u1ee9 \u00fd ngh\u0129 ho\u1eb7c c\u1ea3m gi\u00e1c lo \u00e2u v\u00e0o b\u1ea5t c\u1ee9 l\u00fac n\u00e0o v\u1edbi chuy\u00ean gia ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe.<\/p>\n<p><em>R\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a.<\/em><\/p>\n<p>\u0110\u00e3 c\u00f3 c\u00e1c b\u00e1o c\u00e1o sau khi thu\u1ed1c l\u01b0u h\u00e0nh v\u1ec1 c\u00e1c bi\u1ebfn c\u1ed1 li\u00ean quan \u0111\u1ebfn gi\u1ea3m ch\u1ee9c n\u0103ng \u0111\u01b0\u1eddng ti\u00eau h\u00f3a d\u01b0\u1edbi (v\u00ed d\u1ee5: t\u1eafc ru\u1ed9t, li\u1ec7t ru\u1ed9t, t\u00e1o b\u00f3n khi pregabalin \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb k\u1ebft h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y t\u00e1o b\u00f3n, nh\u01b0 thu\u1ed1c gi\u1ea3m \u0111au opioid. Khi d\u00f9ng k\u1ebft h\u1ee3p pregabalin v\u00e0 opioid, c\u1ea7n xem x\u00e9t c\u00e1c bi\u1ec7n ph\u00e1p ng\u0103n ng\u1eeba t\u00e1o b\u00f3n (\u0111\u1eb7c bi\u1ec7t l\u00e0 \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n n\u1eef v\u00e0 ng\u01b0\u1eddi gi\u00e0).<\/p>\n<p><em>Ph\u1ea3n \u1ee9ng da nghi\u00eam tr\u1ecdng<\/em><\/p>\n<p>\u0110\u00e3 c\u00f3 b\u00e1o c\u00e1o sau khi thu\u1ed1c l\u01b0u h\u00e0nh r\u1ea5t hi\u1ebfm c\u00e1c ph\u1ea3n \u1ee9ng da nghi\u00eam tr\u1ecdng, bao g\u1ed3m h\u1ed9i ch\u1ee9ng Stevens-Johnson (sJS), ho\u1ea1i t\u1eed bi\u1ec3u b\u00ec nhi\u1ec5m \u0111\u1ed9c(TEN), vi\u00eam da tr\u00f3c v\u1ea3y ph\u1ea3n \u1ee9ng da b\u00f3ng n\u01b0\u1edbc v\u00e0 h\u1ed3ng ban \u0111a d\u1ea1ng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi pregabalin. T\u1ef7 l\u1ec7 b\u00e1o c\u00e1o sau khi thu\u1ed1c l\u01b0u h\u00e0nh n\u00f3i chung l\u00e0 ch\u1ea5p nh\u1eadn \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 trong b\u00e1o c\u00e1o. H\u1ea7u h\u1ebft c\u00e1c b\u00e1o c\u00e1o l\u00e0 \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n d\u00f9ng thu\u1ed1c \u0111\u1ed3ng th\u1eddi c\u0169ng g\u1eafn li\u1ec1n v\u1edbi ti\u1ec1m n\u0103ng ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c ph\u1ea3n \u1ee9ng da nghi\u00eam tr\u1ecdng. V\u00ec v\u1eady, trong h\u1ea7u h\u1ebft c\u00e1c tr\u01b0\u1eddng h\u1ee3p, nguy\u00ean nh\u00e2n li\u00ean quan v\u1edbi Pregabalin kh\u00f4ng th\u1ec3 \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp r\u00f5 r\u00e0ng. B\u1ec7nh nh\u00e2n n\u00ean bi\u1ebft r\u1eb1ng n\u1ebfu h\u1ecd c\u00f3 m\u1ed9t ph\u00e1t ban da, h\u1ecd n\u00ean ng\u1eebng \u0111i\u1ec1u tr\u1ecb v\u00e0 li\u00ean h\u1ec7 v\u1edbi b\u00e1c s\u0129 c\u1ee7a m\u00ecnh \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 v\u00e0 t\u01b0 v\u1ea5n.<\/p>\n<p><em>S\u1eed d\u1ee5ng sai, l\u1ea1m d\u1ee5ng ho\u1eb7c l\u1ec7 thu\u1ed9c thu\u1ed1c<\/em><\/p>\n<p>C\u1ea9n th\u1eadn tr\u1ecdng v\u1edbi c\u00e1c b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed nghi\u1ec7n thu\u1ed1c. Theo d\u00f5i c\u00e1c d\u1ea5u hi\u1ec7u l\u1ea1m d\u1ee5ng thu\u1ed1c (nh\u01b0 nh\u1eddn thu\u1ed1c, xu h\u01b0\u1edbng t\u0103ng li\u1ec1u hay h\u00e0nh vi t\u00ecm ki\u1ebfm thu\u1ed1c). Trong c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng c\u00f3 \u0111\u1ed1i ch\u1ee9ng,t\u1ef7 l\u1ec7 b\u1ec7nh nh\u00e2n d\u00f9ng pregabalin c\u00f3 bi\u1ec3u hi\u1ec7n s\u1ea3ng kho\u00e1i l\u00e0 4% so v\u1edbi 1% \u1edf nh\u00f3m ch\u1ee9ng. Trong c\u00e1c nghi\u00ean c\u1ee9u tr\u00ean qu\u1ea7n th\u1ec3 b\u1ec7nh nh\u00e2n, t\u1ef7 l\u1ec7 n\u00e0y l\u1edbn h\u01a1n, t\u1eeb 1-12%. Khi ng\u1eebng thu\u1ed1c nhanh v\u00e0 \u0111\u1ed9t ng\u1ed9t, th\u1ea5y c\u00e1c bi\u1ec3u hi\u1ec7n c\u1ee7a l\u1ec7 thu\u1ed9c thu\u1ed1c nh\u01b0 m\u1ea5t ng\u1ee7, n\u00f4n, \u0111au \u0111\u1ea7u, ti\u00eau ch\u1ea3y.<\/p>\n<p><em>B\u1ec7nh n\u00e3o<\/em><\/p>\n<p>M\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p b\u1ec7nh n\u00e3o \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o, ch\u1ee7 y\u1ebfu l\u00e0 \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 s\u1eb5n b\u1ec7nh m\u00e0 c\u00f3 th\u1ec3 th\u00fac \u0111\u1ea9y b\u1ec7nh l\u00fd n\u00e3o.<\/p>\n<p><em>T\u0103ng CPK<\/em><\/p>\n<p>Pregabalin c\u00f3 th\u1ec3 l\u00e0m t\u0103ng CPK v\u00e0 c\u00f3 th\u1ec3 g\u00e2y globin c\u01a1 &#8211; ni\u1ec7u k\u1ecbch ph\u00e1t (m\u1eb7c d\u00f9 hi\u1ebfm g\u1eb7p). B\u1ec7nh nh\u00e2n c\u1ea7n th\u00f4ng b\u00e1o v\u1edbi b\u00e1c s\u0129 khi c\u1ed5 \u0111au, y\u1ebfu c\u01a1, t\u0103ng nh\u1ea1y c\u1ea3m \u0111au, \u0111\u1eb7c bi\u1ec7t khi c\u00f3 k\u00e8m theo s\u1ed1t v\u00e0\/ho\u1eb7c m\u1ec7t m\u1ecfi, kh\u00f3 ch\u1ecbu. Ph\u1ea3i ng\u1eebng thu\u1ed1c khi c\u00f3 bi\u1ec3u hi\u1ec7n c\u1ee7a b\u1ec7nh c\u01a1.<\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>Pregabalin c\u00f3 th\u1ec3 g\u00e2y ch\u00f3ng m\u1eb7t ho\u1eb7c bu\u1ed3n ng\u1ee7. Do v\u1eady, b\u1ec7nh nh\u00e2n kh\u00f4ng n\u00ean l\u00e1i xe, v\u1eadn h\u00e0nh m\u00e1y m\u00f3c ph\u1ee9c t\u1ea1p.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"45-su-dung-cho-phu-nu-co-thai-va-cho-con-bu\"><\/span>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: B3<\/p>\n<p>US FDA pregnancy category: C<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>Ch\u01b0a c\u00f3 c\u00e1c d\u1eef li\u1ec7u \u0111\u1ea7y \u0111\u1ee7 v\u1ec1 d\u00f9ng regabalin tr\u00ean ph\u1ee5 n\u1eef c\u00f3 thai. C\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt \u0111\u00e3 cho th\u1ea5y t\u00e1c d\u1ee5ng g\u00e2y \u0111\u1ed9c tr\u00ean kh\u1ea3 n\u0103ng sinh s\u1ea3n. Nguy c\u01a1 v\u1ec1 r\u1ee7i ro tr\u00ean ng\u01b0\u1eddi ch\u01b0a \u0111\u01b0\u1ee3c bi\u1ebft.<\/p>\n<p>Kh\u00f4ng n\u00ean d\u00f9ng pregabalin khi \u0111ang mang thai tr\u1eeb khi th\u1ef1c s\u1ef1 c\u1ea7n thi\u1ebft v\u00e0 c\u00f3 c\u00e2n nh\u1eafc k\u1ef9 l\u1ee3i \u00edch mang l\u1ea1i cho ng\u01b0\u1eddi m\u1eb9 cao h\u01a1n so v\u1edbi nguy c\u01a1 cho thai nhi.<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>Ch\u01b0a bi\u1ebft \u0111\u01b0\u1ee3cpregabalin c\u00f3 b\u00e0i ti\u1ebft qua s\u1eefa ng\u01b0\u1eddi hay kh\u00f4ng tuy nhi\u00ean, thu\u1ed1c c\u00f3 xu\u1ea5t hi\u1ec7n trong s\u1eefa chu\u1ed9t. Do v\u1eady, kh\u00f4ng \u0111\u01b0\u1ee3c nu\u00f4i con b\u1eb1ng s\u1eefa m\u1eb9 khi \u0111ang d\u00f9ng thu\u1ed1c<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h2><span class=\"ez-toc-section\" id=\"46-tac-dung-khong-mong-muon-adr\"><\/span>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>T\u1ea7n su\u1ea5t g\u1eb7p ADR c\u00f3 th\u1ec3 b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi li\u1ec1u d\u00f9ng ho\u1eb7c c\u00e1c li\u1ec7u ph\u00e1p ph\u1ed1i h\u1ee3p.<\/p>\n<p>B\u1ea3ng t\u00f3m t\u1eaft c\u00e1c ph\u1ea3n \u1ee9ng kh\u00f4ng mong mu\u1ed1n:<\/p>\n<p>C\u00e1c c\u01a1 quan: t\u1ea7n su\u1ea5t (%) :C\u00e1c ph\u1ea3n \u1ee9ng kh\u00f4ng mong mu\u1ed1n<\/p>\n<p><em>Tim m\u1ea1ch <\/em><\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p: Ph\u00f9 ngo\u1ea1i vi.<\/p>\n<p>\u00cdt g\u1eb7p: \u0110au ng\u1ef1c, ph\u00f9.<\/p>\n<p><em>Th\u1ea7n kinh trung \u01b0\u01a1ng<\/em><\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p: ch\u00f3ng m\u1eb7t, ng\u1ee7 g\u00e0, m\u1ea5t \u0111i\u1ec1u v\u1eadn, \u0111au \u0111\u1ea7u<\/p>\n<p>\u00cdt g\u1eb7p: Vi\u00eam d\u00e2y th\u1ea7n kinh, suy ngh\u0129 b\u1ea5t th\u01b0\u1eddng, m\u1ec7t m\u1ecfi, l\u00fa l\u1eabn, s\u1ea3ng kho\u00e1i, r\u1ed1i lo\u1ea1n ng\u00f4n ng\u1eef, r\u1ed1i lo\u1ea1n ch\u00fa \u00fd, m\u1ea5t ph\u1ed1i h\u1ee3p \u0111\u1ed9ng t\u00e1c, m\u1ea5t\/ gi\u1ea3m tr\u00ed nh\u1edb, \u0111au, ch\u00f3ng m\u1eb7t, c\u1ea3m gi\u00e1c b\u1ea5t th\u01b0\u1eddng\/ gi\u1ea3m c\u1ea3m gi\u00e1c, lo l\u1eafng, tr\u1ea7m c\u1ea3m. m\u1ea5t \u0111\u1ecbnh h\u01b0\u1edbng, ng\u1ee7 l\u1ecbm, s\u1ed1t, m\u1ea5t nh\u00e2n c\u00e1ch, t\u0103ng tr\u01b0\u01a1ng l\u1ef1c c\u01a1, tr\u1ea1ng th\u00e1i li b\u00ec, s\u1eefng s\u1edd ho\u1eb7c k\u00edch \u0111\u1ed9ng.<\/p>\n<p><em>H\u1ec7 ti\u00eau h\u00f3a<\/em><\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p : T\u0103ng c\u00e2n, kh\u00f4 mi\u1ec7ng.<\/p>\n<p><em>H\u1ec7 c\u01a1 \u2013 x\u01b0\u01a1ng<\/em><\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p: Run c\u01a1<\/p>\n<p>\u00cdt g\u1eb7p: r\u1ed1i lo\u1ea1n th\u0103ng b\u1eb1ng, d\u00e1ng di b\u1ea5t th\u01b0\u1eddng, y\u1ebfu c\u01a1, \u0111au kh\u1edbp, gi\u1eadt c\u01a1, \u0111au l\u01b0ng, co th\u1eaft c\u01a1, gi\u1eadt rung c\u01a1, d\u1ecb c\u1ea3m, t\u0103ng CPK, chu\u1ed9t r\u00fat, \u0111au c\u01a1, nh\u01b0\u1ee3c c\u01a1.<\/p>\n<p><em>M\u1eaft <\/em><\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p: Nh\u00ecn m\u1edd, song th\u1ecb.<\/p>\n<p>\u00cdt g\u1eb7p : R\u1ed3i lo\u1ea1n th\u1ecb gi\u00e1c, gi\u1ea3m th\u1ecb l\u1ef1c, rung gi\u1eadt nh\u00e3n c\u1ea7u, vi\u00eam k\u1ebft m\u1ea1c<\/p>\n<p><em>Da: <\/em><\/p>\n<p>\u00cdt g\u1eb7p : Ph\u00f9 m\u1eb7t, v\u1ebft th\u00e2m t\u00edm, ng\u1ee9a.<\/p>\n<p><em>N\u1ed9i ti\u1ebft v\u00e0 chuy\u1ec3n h\u00f3a<\/em><\/p>\n<p>\u00cdt g\u1eb7p : \u1ee8 d\u1ecbch, gi\u1ea3m glucose huy\u1ebft.<\/p>\n<p><em>D\u1ea1 d\u00e0y ru\u1ed9t<\/em><\/p>\n<p>\u00cdt g\u1eb7p : T\u00e1o b\u00f3n, th\u00e8m \u0103n, \u0111\u1ea7y h\u01a1i, n\u00f4n, \u0111au b\u1ee5ng, vi\u00eam d\u1ea1 d\u00e0y ru\u1ed9t<\/p>\n<p><em>Sinh d\u1ee5c ti\u1ebft ni\u1ec7u:<\/em><\/p>\n<p>\u00cdt g\u1eb7p: Ti\u1ec3u nhi\u1ec1u v\u00e0 ti\u1ec3u kh\u00f4ng t\u1ef1 ch\u1ee7, m\u1ea5t kho\u00e1i c\u1ea3m, gi\u1ea3m t\u00ecnh d\u1ee5c<\/p>\n<p><em>M\u00e1u: <\/em><\/p>\n<p>\u00cdt g\u1eb7p: Gi\u1ea3m ti\u1ec3u c\u1ea7u.<\/p>\n<p><em>Tai :<\/em><\/p>\n<p>\u00cdt g\u1eb7p: Gi\u1ea3m th\u00ednh l\u1ef1c.<\/p>\n<p><em>H\u00f4 h\u1ea5p :<\/em><\/p>\n<p>\u00cdt g\u1eb7p: Vi\u00eam xoang, kh\u00f3 th\u1edf, vi\u00eam ph\u1ebf qu\u1ea3n, vi\u00eam h\u1ecdng \u2013 thanh qu\u1ea3n.<\/p>\n<p><em>Kh\u00e1c <\/em><\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p: Nhi\u1ec5m khu\u1ea9n.<\/p>\n<p>\u00cdt g\u1eb7p: H\u1ed9i ch\u1ee9ng gi\u1ea3 c\u00fam, ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng.<\/p>\n<p>Hi\u1ebfm g\u1eb7p : \u00c1p-xe, suy th\u1eadn c\u1ea5p, l\u1ec7 thu\u1ed9c thu\u1ed1c (hi\u1ebfm g\u1eb7p), k\u00edch \u0111\u1ed9ng, albumin ni\u1ec7u, ph\u1ea3n \u1ee9ng ph\u1ea3n v\u1ec7, thi\u1ebfu m\u00e1u, ph\u00f9 m\u1ea1ch, r\u1ed1i lo\u1ea1n ng\u00f4n ng\u1eef, vi\u00eam d\u1ea1 d\u00e0y, ng\u1eebng th\u1edf&#8230;<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<h2><span class=\"ez-toc-section\" id=\"47-huong-dan-cach-xu-tri-adr\"><\/span>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>M\u1ed9t s\u1ed1 ADR l\u00e0m ng\u01b0\u1eddi b\u1ec7nh ph\u1ea3i ng\u1eebng thu\u1ed1c. 4% ng\u01b0\u1eddi b\u1ec7nh b\u1ecb ch\u00f3ng m\u1eb7t ho\u1eb7c bu\u1ed3n ng\u1ee7 ph\u1ea3i ng\u1eebng \u0111i\u1ec1u tr\u1ecb. \u0110a s\u1ed1 c\u00e1c tr\u01b0\u1eddng h\u1ee3p b\u1ecb nh\u00ecn m\u1edd t\u1ef1 h\u1ebft khi ti\u1ebfp t\u1ee5c \u0111i\u1ec1u tr\u1ecb, d\u01b0\u1edbi 1% ng\u01b0\u1eddi b\u1ec7nh ph\u1ea3i ng\u1eebng \u0111i\u1ec1u tr\u1ecb. N\u1ebfu r\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c k\u00e9o d\u00e0i, c\u1ea7n cho th\u0103m kh\u00e1m m\u1eaft.<\/p>\n<p>Ph\u1ea3i ng\u1eebng thu\u1ed1c khi b\u1ecb b\u1ec7nh c\u01a1, ho\u1eb7c khi th\u1ea5y n\u1ed3ng \u0111\u1ed9 CPK huy\u1ebft thanh t\u0103ng cao \u00edt nh\u1ea5t g\u1ea5p 3 l\u1ea7n m\u1ee9c cao c\u1ee7a gi\u1edbi h\u1ea1n b\u00ecnh th\u01b0\u1eddng. Ph\u1ea3i ng\u1eebng thu\u1ed1c khi c\u00f3 t\u0103ng c\u00e2n, ph\u00f9 ngo\u1ea1i bi\u00ean \u1edf ng\u01b0\u1eddi \u0111\u00e3 c\u00f3 b\u1ec7nh tim t\u1eeb tr\u01b0\u1edbc.<\/p>\n<p>Ph\u00f9 m\u1ea1ch tuy hi\u1ebfm x\u1ea3y ra nh\u01b0ng th\u01b0\u1eddng x\u1ea3y ra ngay khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb pregabalin; do \u0111\u00f3, tr\u01b0\u1edbc khi cho b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb b\u1eb1ng pregabalin, c\u1ea7n h\u1ecfi k\u1ef9 ti\u1ec1n s\u1eed m\u1eabn c\u1ea3m v\u00e0 chu\u1ea5n b\u1ecb ph\u01b0\u01a1ng ti\u1ec7n c\u1ea5p c\u1ee9u th\u00edch h\u1ee3p.<\/p>\n<p>Ngo\u00e0i ra, c\u1ea7n th\u00f4ng b\u00e1o cho ng\u01b0\u1eddi b\u1ec7nh v\u00e0 gia \u0111\u00ecnh bi\u1ebft v\u1ec1 ti\u1ec1m n\u0103ng nguy c\u01a1 t\u1ef1 s\u00e1t khi d\u00f9ng thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh. Ph\u1ea3i ch\u00fa \u00fd \u0111\u1ebfn c\u00e1c tri\u1ec7u ch\u1ee9ng b\u00e1o hi\u1ec7u nh\u01b0 lo \u00e2u, v\u1eadt v\u00e3, hung h\u00e3n, t\u1ea5n c\u00f4ng, ch\u1ed1ng \u0111\u1ed1i, thao cu\u1ed3ng, m\u1ea5t ng\u1ee7 v\u00e0 tr\u1ea7m c\u1ea3m. Gia \u0111\u00ecnh c\u1ea7n theo d\u00f5i s\u00e1t ng\u01b0\u1eddi b\u1ec7nh.<\/p>\n<p>Khi ng\u1eebng thu\u1ed1c, tr\u00e1nh ng\u1eebng \u0111\u1ed9t ng\u1ed9t, gi\u1ea3m d\u1ea7n li\u1ec1u trong kho\u1ea3ng \u00edt nh\u1ea5t m\u1ed9t tu\u1ea7n.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"48-tuong-tac-voi-cac-thuoc-khac\"><\/span>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>V\u00ec Pregabalin \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb ch\u00ednh qua n\u01b0\u1edbc ti\u1ec3u \u1edf d\u1ea1ng ch\u01b0a chuy\u1ec3n h\u00f3a, m\u1ed9t l\u01b0\u1ee3ng kh\u00f4ng \u0111\u00e1ng k\u1ec3 \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a (&lt;2% c\u1ee7a li\u1ec1u d\u00f9ng t\u00ecm th\u1ea5y trong n\u01b0\u1edbc ti\u1ec3u \u1edf d\u1ea1ng chuy\u1ec3n h\u00f3a), kh\u00f4ng \u1ee9c ch\u1ebf chuy\u1ec3n h\u00f3a thu\u1ed1c in vitro v\u00e0 kh\u00f4ng g\u1eafn k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng, pregabalin kh\u00f4ng t\u1ea1o ra t\u01b0\u01a1ng t\u00e1c ho\u1eb7c b\u1ecb t\u01b0\u01a1ng t\u00e1c d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc.<\/p>\n<p><em>T\u01b0\u01a1ng t\u00e1c v\u1ec1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/em><\/p>\n<p>C\u00e1c nghi\u00ean c\u1ee9u in Vivo kh\u00f4ng cho th\u1ea5y li\u00ean quan v\u1ec1 t\u01b0\u01a1ng t\u00e1c d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc l\u00e2m s\u00e0ng c\u1ee7a pregabalin v\u1edbi carbamazepin, acid valproic, lamotrigin, phenytoin, phenobarbital, topiramat, gabapentin, lorazepam, oxycodon ho\u1eb7c ethanol. Ph\u00e2n t\u00edch d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc tr\u00ean c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng, l\u1ee3i ti\u1ec3u, insulin v\u00e0 tiacabin kh\u00f4ng c\u00f3 \u1ea3nh h\u01b0\u1edfng l\u00e2m s\u00e0ng \u0111\u00e1ng k\u1ec3 n\u00e0o \u0111\u1ebfn thanh th\u1ea3i pregabalin,<\/p>\n<p>D\u00f9ng chung pregabalin v\u1edbi c\u00e1c thu\u1ed1c tr\u00e1nh thai \u0111\u01b0\u1eddng u\u1ed1ng norethisteron v\u00e0\/ho\u1eb7c ethilyl estradiol kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 \u1ed5n \u0111\u1ecbnh v\u1ec1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a c\u1ea3 hai lo\u1ea1i thu\u1ed1c<\/p>\n<p><em>T\u01b0\u01a1ng t\u00e1c v\u1ec1 d\u01b0\u1ee3c l\u1ef1c h\u1ecdc<\/em><\/p>\n<p>Pregabalin c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng c\u1ee7a ethanol v\u00e0 lorazepam. Trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng c\u00f3 ki\u1ec3m ch\u1ee9ng, d\u00f9ng li\u1ec1u \u0111a \u0111\u01b0\u1eddng u\u1ed1ng pregabalin k\u1ebft h\u1ee3p v\u1edbi oxycodon, lorazepam, ho\u1eb7c ethanol kh\u00f4ng c\u00f3 t\u00e1c \u0111\u1ed9ng l\u00e2m s\u00e0ng quan tr\u1ecdng n\u00e0o \u0111\u1ebfn h\u00f4 h\u1ea5p. Sau khi thu\u1ed1c l\u01b0u h\u00e0nh tr\u00ean th\u1ecb tr\u01b0\u1eddng \u0111\u00e3 c\u00f3 b\u00e1o c\u00e1o v\u1ec1 suy h\u00f4 h\u1ea5p v\u00e0 h\u00f4n m\u00ea \u1edf b\u1ec7nh nh\u00e2n d\u00f9ng pregabalin v\u00e0 c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng kh\u00e1c. S\u1ef1 c\u00f3 m\u1eb7t c\u1ee7a pregabalin l\u00e0m t\u0103ng th\u00eam r\u1ed1i lo\u1ea1n nh\u1eadn th\u1ee9c v\u00e0 ch\u1ee9c n\u0103ng v\u1eadn \u0111\u1ed9ng g\u00e2y ra b\u1edfi oxycodon.<\/p>\n<p>Khi d\u00f9ng ph\u1ed1i h\u1ee3p pregabalin v\u1edbi thiazolidinedione (thu\u1ed1c ch\u1ed1ng \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng) c\u00f3 nguy c\u01a1 t\u0103ng tr\u1ecdng l\u01b0\u1ee3ng c\u01a1 th\u1ec3 v\u00e0 ph\u00f9 cao h\u01a1n so v\u1edbi khi d\u00f9ng pregabalin \u0111\u01a1n \u0111\u1ed9c.<\/p>\n<p><em>T\u01b0\u01a1ng t\u00e1c kh\u00e1c<\/em><\/p>\n<p>Pregabalin l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 t\u00e1c d\u1ee5ng c\u1ee7a methotimeprazin, c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf thu h\u1ed3i serotonin ch\u1ecdn l\u1ecdc<\/p>\n<p>N\u1ed3ng \u0111\u1ed9 t\u00e1c d\u1ee5ng c\u1ee7a pregabalin \u0111\u01b0\u1ee3c t\u0103ng l\u00ean b\u1edfi droperidol, hydroxyzin, methotrimeprazin.<\/p>\n<p>N\u1ed3ng \u0111\u1ed9 v\u00e0 t\u00e1c d\u1ee5ng c\u1ee7a pregabalin b\u1ecb gi\u1ea3m b\u1edfi ketorolac, ketorolac (nh\u1ecf m\u0169i), ketorolac (\u0111\u01b0\u1eddng to\u00e0n th\u00e2n), mefloquin.<\/p>\n<p><em>T\u01b0\u01a1ng t\u00e1c gi\u1eefa thu\u1ed1c v\u00e0 th\u1ee9c \u0103n<\/em><\/p>\n<p>T\u1ef7 l\u1ec7 h\u1ea5p thu c\u1ee7a pregabalin gi\u1ea3m khi d\u00f9ng c\u00f9ng th\u1ee9c \u0103n d\u1eabn \u0111\u1ebfn gi\u1ea3m kho\u1ea3ng 25-30% v\u00e0 k\u00e9o d\u00e0i tay sau kho\u1ea3ng 3 gi\u1edd. Tuy nhi\u00ean, d\u00f9ng pregabalin c\u00f9ng th\u1ee9c \u0103n kh\u00f4ng c\u00f3 \u1ea3nh h\u01b0\u1edfng l\u00e2m s\u00e0ng \u0111\u00e1ng k\u1ec3 n\u00e0o \u0111\u1ebfn m\u1ee9c \u0111\u1ed9 h\u1ea5p thu pregabalin.Vv\u1eady, pregabalin c\u00f3 th\u1ec3 u\u1ed1ng c\u00f9ng ho\u1eb7c kh\u00f4ng c\u00f9ng v\u1edbi th\u1ee9c \u0103n.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"49-qua-lieu-va-xu-tri\"><\/span>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>D\u1ea5u hi\u1ec7u, tri\u1ec7u ch\u1ee9ng<\/em><\/p>\n<p>Li\u1ec1u d\u00f9ng cao nh\u1ea5t c\u1ee7a pregabalin trong nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng tr\u00ean 1 b\u1ec7nh nh\u00e2n l\u00e0 15.000 mg nh\u01b0ng kh\u00f4ng g\u00e2y t\u1eed vong. C\u00e1c ph\u1ea3n \u1ee9ng ph\u1ee5 do qu\u00e1 li\u1ec1u kh\u00f4ng kh\u00e1c bi\u1ec7t v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng v\u1edbi c\u00e1c ph\u1ea3n \u1ee9ng ph\u1ee5 khi d\u00f9ng li\u1ec1u khuy\u1ebfn c\u00e1o.<\/p>\n<p>Trong c\u00e1c b\u00e1o c\u00e1o sau khi thu\u1ed1c l\u01b0u h\u00e0nh, m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p t\u1eed vong khi d\u00f9ng pregabalin k\u1ebft h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c trong \u0111\u00f3 li\u1ec1u pregabalin l\u00e0 800 mg\/ng\u00e0y. Kh\u00f4ng c\u00f3 tr\u01b0\u1eddng h\u1ee3p n\u00e0o trong s\u1ed1 b\u1ec7nh nh\u00e2n n\u00e0y \u0111\u00e3 x\u00e1c \u0111\u1ecbnh nguy\u00ean nh\u00e2n g\u00e2y ch\u1ebft l\u00e0 do pregabalin. Li\u1ec1u \u0111\u01a1n th\u1ea5p nh\u1ea5t pregabalin g\u00e2y ch\u1ebft v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh.<\/p>\n<p>C\u00e1c ph\u1ea3n \u1ee9ng ph\u1ee5 th\u01b0\u1eddng g\u1eb7p nh\u1ea5t khi d\u00f9ng pregabalin qu\u00e1 li\u1ec1u (kho\u1ea3ng li\u1ec1u t\u1eeb 800mg\/ng\u00e0y l\u00ean \u0111\u1ebfn 11.500 mg d\u1ea1ng li\u1ec1u \u0111\u01a1n) bao g\u1ed3m r\u1ed1i lo\u1ea1n c\u1ea3m x\u00fac, bu\u1ed3n ng\u1ee7, tr\u1ea1ng th\u00e1i l\u1eabn l\u1ed9n tr\u1ea7m c\u1ea3m, lo l\u1eafng v\u00e0 b\u1ed3n ch\u1ed3n.<\/p>\n<p><em>X\u1eed tr\u00ed qu\u00e1 li\u1ec1u<\/em><\/p>\n<p>Kh\u00f4ng c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u khi d\u00f9ng qu\u00e1 li\u1ec1u pregabalin. N\u1ebfu \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh, c\u00f3 th\u1ec3 lo\u1ea1i thu\u1ed1c ch\u01b0a h\u1ea5p thu b\u1eb1ng thu\u1ed1c g\u00e2y n\u00f4n hay r\u1eeda d\u1ea1 d\u00e0y; c\u1ea7n l\u01b0u \u00fd b\u1ea3o v\u1ec7 \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p c\u1ee7a b\u1ec7nh nh\u00e2n. Ch\u0103m s\u00f3c h\u1ed7 tr\u1ee3 t\u1ed5ng qu\u00e1t nh\u01b0 theo d\u00f5i c\u00e1c d\u1ea5u hi\u1ec7u sinh t\u1ed3n v\u00e0 quan s\u00e1t t\u00ecnh tr\u1ea1ng b\u1ec7nh nh\u00e2n tr\u00ean l\u00e2m s\u00e0ng.<\/p>\n<p><em>Th\u1ea9m t\u00e1ch m\u00e0u<\/em><\/p>\n<p>Pregabalin \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft c\u00f3 hi\u1ec7u qu\u1ea3 qua th\u1ea9m t\u00e1ch m\u00e1u (sau 4 gi\u1edd th\u1ea9m t\u00e1ch m\u00e1u, n\u1ed3ng \u0111\u1ed9 Pregabalin trong huy\u1ebft thanh gi\u1ea3m g\u1ea7n 50%).<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h1><span class=\"ez-toc-section\" id=\"5-co-che-tac-dung-cua-thuoc\"><\/span>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"51-duoc-luc-hoc\"><\/span>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Nh\u00f3m d\u01b0\u1ee3c:Pregabalin l\u00e0 m\u1ed9t thu\u1ed1c ch\u1ed1ng co gi\u1eadt v\u00e0 gi\u1ea3m \u0111au.<\/p>\n<p>M\u00e3 ATC: N03AX16<\/p>\n<p>Pregabalin g\u1eafn k\u1ebft v\u1edbi 1 \u0111\u01a1n v\u1ecb ph\u1ee5 alpha2-delta protein c\u1ee7a c\u00e1c k\u00eanh calci mang \u0111i\u1ec7n th\u1ebf trong c\u00e1c m\u00f4 c\u1ee7a h\u1ec7 th\u1ed1ng th\u1ea7n kinh trung \u01b0\u01a1ng. In vitro, pregabalin l\u00e0m gi\u1ea3m d\u00f2ng ch\u1ea3y calci \u1edf \u0111\u1ea7u cu\u1ed1i d\u00e2y th\u1ea7n kinh, ng\u0103n ch\u1eb7n ph\u00f3ng th\u00edch ch\u1ea5t d\u1eabn truy\u1ec1n th\u1ea7n kinh nh\u01b0 glutamat . Qua c\u01a1 ch\u1ebf n\u00e0y, pregabalin c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh xung \u0111\u1ed9ng th\u1ea7n kinh li\u00ean quan \u0111\u1ebfn d\u1eabn truy\u1ec1n c\u01a1n \u0111au. Tuy nhi\u00ean, m\u1ed1i li\u00ean quan tr\u00ean l\u00e2m s\u00e0ng c\u1ee7a nh\u1eefng ph\u00e1t hi\u1ec7n n\u00e0y\u1edfng\u01b0\u1eddi ch\u01b0a \u0111\u01b0\u1ee3c bi\u1ebft. Pregabalin g\u1eafn k\u1ebft m\u1ea1nh v\u00e0o protein alpha2-delta m\u1ed9t \u0111\u01a1n v\u1ecb ph\u1ee5 c\u1ee7a k\u00eanh calci) c\u1ee7a m\u00f4 n\u00e3o v\u00e0 c\u00f3 t\u00e1c d\u1ee5ng gi\u1ea3m \u0111au, ch\u1ed1ng \u0111\u1ed9ng kinh v\u00e0 gi\u1ea3m lo \u00e2u. V\u1ec1 m\u1eb7t h\u00f3a h\u1ecdc, pregabalin l\u00e0 (S)-3-(aminomethyl)-5-methylhexanoic acid.<\/p>\n<p>M\u1eb7c d\u00f9 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a Pregabalin ch\u01b0a \u0111\u01b0\u1ee3c bi\u1ebft ch\u00ednh x\u00e1c, c\u00e1c k\u1ebft qu\u1ea3 tr\u00ean chu\u1ed9t nh\u1eaft bi\u1ebfn \u0111\u1ed5i gen v\u00e0 v\u1edbi c\u00e1c h\u1ee3p ch\u1ea5t c\u00f3 c\u1ea5u tr\u00fac li\u00ean quan \u0111\u1ebfn Pregabalin cho th\u1ea5y r\u1eb1ng g\u1eafn k\u1ebft ch\u1ecdn l\u1ecdc v\u1edbi protein alpha-delta l\u00e0 c\u1ea7n thi\u1ebft cho t\u00e1c \u0111\u1ed9ng gi\u1ea3m \u0111au, ch\u1ed1ng \u0111\u1ed9ng kinh v\u00e0 gi\u1ea3m c\u0103ng th\u1eb3ng th\u1ea7n kinh trong c\u00e1c m\u00f4 h\u00ecnh th\u1eed nghi\u1ec7m tr\u00ean \u0111\u1ed9ng v\u1eadt. In vitro, pregabalin l\u00e0m gi\u1ea3m ph\u00f3ng th\u00edch m\u1ed9t s\u1ed1 ch\u1ea5t d\u1eabn truy\u1ec1n th\u1ea7n kinh, g\u1ee3i \u00fd v\u1ec1 t\u00e1c \u0111\u1ed9ng \u0111i\u1ec1u ch\u1ec9nh tr\u00ean ch\u1ee9c n\u0103ng k\u00eanh calci<\/p>\n<p>H\u00f3a truy\u1ec1n th\u1ea7n kinh, n\u01a1i \u00fd v\u1ec1.<\/p>\n<p>Pregabalin kh\u00f4ng b\u1eaft ch\u01b0\u1edbc t\u00e1c d\u1ee5ng c\u1ee7a GABA \u1edf c\u00e1c th\u1ee5 th\u1ec3 GABAA ho\u1eb7c GABAB c\u0169ng kh\u00f4ng l\u00e0m t\u0103ng c\u00e1c \u0111\u00e1p \u1ee9ng GABAA nh\u01b0 c\u00e1c benzodiazepin ho\u1eb7c barbiturat. Ng\u01b0\u1ee3c l\u1ea1i v\u1edbi c\u00e1c ch\u1ea5t ch\u1eb9n k\u00eanh calci tr\u00ean m\u1ea1ch m\u00e1u, pregabalin kh\u00f4ng l\u00e0m thay \u0111\u1ed5i huy\u1ebft \u00e1p h\u1ec7 th\u1ed1ng hay ch\u1ee9c n\u0103ng tim. C\u00e1c k\u1ebft qu\u1ea3 in vitro v\u00e0 in vivo kh\u00e1c nhau ph\u00e2n bi\u1ec7t pregabalin v\u1edbi c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf h\u1ea5p thu GABA ho\u1eb7c ch\u1ea5t \u1ee9c ch\u1ebf GABA transaminase. Ngo\u00e0i ra, pregabalin kh\u00f4ng ch\u1ecdn c\u00e1c k\u00eanh natri, kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh t\u1ea1i c\u00e1c th\u1ee5 th\u1ec3 opiat, kh\u00f4ng l\u00e0m thay \u0111\u1ed5i ho\u1ea1t t\u00ednh enzym cyclooxygenase, kh\u00f4ng ph\u1ea3i l\u00e0 ch\u1ea5t \u0111\u1ed3ng v\u1eadn serotonin, kh\u00f4ng ph\u1ea3i l\u00e0 ch\u1ea5t \u0111\u1ed1i kh\u00e1ng dopamin, v\u00e0 kh\u00f4ng l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf t\u00e1i h\u1ea5p thu dopamin, serotonin hay noradrenalin.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb v\u1edbi pregabalin l\u00e0m gi\u1ea3m h\u00e0nh vi li\u00ean quan \u0111\u1ebfn \u0111au tr\u00ean c\u00e1c m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt v\u1ec1 \u0111au th\u1ea7n kinh trong b\u1ec7nh \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng, t\u1ed5n th\u01b0\u01a1ng d\u00e2y th\u1ea7n kinh ngo\u1ea1i bi\u00ean hay \u0111au do h\u00f3a tr\u1ecb v\u00e0 \u0111au li\u00ean quan \u0111\u1ebfn c\u01a1 x\u01b0\u01a1ng. Ch\u00edch pregabalin v\u00e0o m\u00e0ng n\u00e3o t\u1ee7y \u0111\u1ec3 ng\u0103n ng\u1eeba v\u00e0 l\u00e0m gi\u1ea3m c\u00e1c h\u00e0nh vi li\u00ean quan \u0111\u1ebfn \u0111au g\u00e2y ra do c\u00e1c t\u00e1c nh\u00e2n \u0111\u01b0\u1ee3c ch\u00edch v\u00e0o t\u1ee7y s\u1ed1ng, k\u1ebft qu\u1ea3 g\u1ee3i \u00fd r\u1eb1ng pregabalin t\u00e1c \u0111\u1ed9ng tr\u1ef1c ti\u1ebfp l\u00ean c\u00e1c m\u00f4 t\u1ee7y s\u1ed1ng ho\u1eb7c n\u00e3o<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>Pregabalin g\u1eafn v\u1edbi 1 ti\u1ec3u \u0111\u01a1n v\u1ecb ph\u1ee5 (\u03b1<sub>2<\/sub>&#8211; \u03b4 protein) c\u1ee7a k\u00eanh calci c\u1ed5ng \u0111i\u1ec7n th\u1ebf trong h\u1ec7 th\u1ed1ng th\u1ea7n kinh trung \u01b0\u01a1ng.<\/p>\n<p>B\u1eb1ng ch\u1ee9ng t\u1eeb m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt c\u00f3 t\u1ed5n th\u01b0\u01a1ng th\u1ea7n kinh ch\u1ec9 ra r\u1eb1ng pregabalin gi\u1ea3m gi\u1ea3i ph\u00f3ng ch\u1ea5t d\u1eabn truy\u1ec1n th\u1ea7n kinh c\u1ea3m th\u1ee5 \u0111au ph\u1ee5 thu\u1ed9c v\u00e0o canxi \u1edf t\u1ee7y s\u1ed1ng, c\u00f3 th\u1ec3 th\u00f4ng qua s\u1ef1 ng\u0103n c\u1ea3n v\u1eadn chuy\u1ec3n canxi v\u00e0\/ho\u1eb7c gi\u1ea3m d\u00f2ng canxi. B\u1eb1ng ch\u1ee9ng t\u1eeb c\u00e1c m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt kh\u00e1c c\u00f3 t\u1ed5n th\u01b0\u01a1ng th\u1ea7n kinh cho th\u1ea5y ho\u1ea1t t\u00ednh gi\u1ea3m \u0111au c\u1ee7a pregabalin c\u0169ng c\u00f3 th\u1ec3 gi\u00e1n ti\u1ebfp qua c\u00e1c t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c con \u0111\u01b0\u1eddng ph\u00f3 giao c\u1ea3m v\u00e0 serotonin.<\/p>\n<p><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/p>\n<h2><span class=\"ez-toc-section\" id=\"52-duoc-dong-hoc\"><\/span>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>T\u1ea5t c\u1ea3 t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd sau khi d\u00f9ng pregabalin l\u00e0 do t\u00e1c \u0111\u1ed9ng c\u1ee7a h\u1ee3p ch\u1ea5t g\u1ed1c, pregabalin kh\u00f4ng \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a \u0111\u00e1ng k\u1ec3 \u1edf ng\u01b0\u1eddi.<\/p>\n<p>D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc \u1ed5n \u0111\u1ecbnh c\u1ee7a pregabalin l\u00e0 gi\u1ed1ng nhau tr\u00ean nh\u1eefng ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n kh\u1ecfe m\u1ea1nh, c\u00e1c b\u1ec7nh nh\u00e2n \u0111\u1ed9ng kinh \u0111ang d\u00f9ng thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh v\u00e0 c\u00e1c b\u1ec7nh nh\u00e2n \u0111au m\u00e3n t\u00ednh.<\/p>\n<p><em>H\u1ea5p thu<\/em><\/p>\n<p>Pregabalin \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh khi u\u1ed1ng l\u00fac \u0111\u00f3i, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t \u0111\u01b0\u1ee3c sau 1,5 gi\u1edd trong c\u1ea3 d\u00f9ng li\u1ec1u \u0111\u01a1n v\u00e0 li\u1ec1u \u0111a.<\/p>\n<p>Sinh kh\u1ea3 d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng c\u1ee7a pregabalin &gt; 90% v\u00e0 ph\u1ee5 thu\u1ed9c v\u00e0o li\u1ec1u d\u00f9ng. Trong d\u00f9ng nh\u1eafc l\u1ea1i, t\u00ecnh tr\u1ea1ng \u1ed5n \u0111\u1ecbnh \u0111\u1ea1t \u0111\u01b0\u1ee3c trong 24-48 gi\u1edd. T\u1ef7 l\u1ec7 h\u1ea5p thu c\u1ee7a pregabalin gi\u1ea3m khi d\u00f9ng c\u00f9ng th\u1ee9c \u0103n d\u1eabn \u0111\u1ebfn 4 gi\u1ea3m kho\u1ea3ng 25-30% v\u00e0 k\u00e9o d\u00e0i sau kho\u1ea3ng 3 gi\u1edd. Tuy nhi\u00ean, d\u00f9ng pregabalin c\u00f9ng th\u1ee9c \u0103n kh\u00f4ng c\u00f3 \u1ea3nh h\u01b0\u1edfng l\u00e2m s\u00e0ng \u0111\u00e1ng k\u1ec3 n\u00e0o \u0111\u1ebfn m\u1ee9c \u0111\u1ed9 h\u1ea5p thu pregabalin.<\/p>\n<p><em>Ph\u00e2n b\u1ed1<\/em><\/p>\n<p>Trong c\u00e1c nghi\u00ean c\u1ee9u ti\u1ec1n l\u00e2m s\u00e0ng, pregabalin d\u1ec5 d\u00e0ng qua h\u00e0ng r\u00e0o m\u00e1u n\u00e3o \u1edf chu\u1ed9t nh\u1eaft, chu\u1ed9t c\u1ed1ng v\u00e0 kh\u00ed. Pregabalin qua \u0111\u01b0\u1ee3c nhau thai \u1edf chu\u1ed9t c\u1ed1ng v\u00e0 xu\u1ea5t hi\u1ec7n trong s\u1eefa chu\u1ed9t. \u1ede ng\u01b0\u1eddi th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 c\u1ee7a Pregabalin sau khi d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng kho\u1ea3ng 0,5L\/kg. Pregabalin kh\u00f4ng g\u1eafn k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<p><em>Chuy\u1ec3n h\u00f3a<\/em><\/p>\n<p>Pregabalin \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a kh\u00f4ng \u0111\u00e1ng k\u1ec3 trong c\u01a1 th\u1ec3 ng\u01b0\u1eddi. Sau khi d\u00f9ng Pregabalin ph\u00f3ng x\u1ea1 \u0111\u00e1nh d\u1ea5u, kho\u1ea3ng 98% t\u00ecm th\u1ea5y trong n\u01b0\u1edbc ti\u1ec3u \u1edf d\u1ea1ng Pregabalin ch\u01b0a chuy\u1ec3n h\u00f3a. D\u1eabn xu\u1ea5t N-methylated c\u1ee7a pregabalin, ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh c\u1ee7a Pregabalin \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong n\u01b0\u1edbc ti\u1ec3u, chi\u1ebfm kho\u1ea3ng 0,9% li\u1ec1u d\u00f9ng. Trong nghi\u00ean c\u1ee9u ti\u1ec1n l\u00e2m s\u00e0ng, kh\u00f4ng c\u00f3 d\u1ea5u hi\u1ec7u n\u00e0o v\u1ec1 s\u1ef1 bi\u1ebfn \u0111\u1ed5i pregabalin \u0111\u1ed3ng ph\u00e2n t\u1ea3 tuy\u1ec1n th\u00e0nh \u0111\u1ed3ng ph\u00e2n h\u1eefu tuy\u1ec1n.<\/p>\n<p><em>Th\u1ea3i tr\u1eeb<\/em><\/p>\n<p>Pregabalin \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb kh\u1ecfi h\u1ec7 tu\u1ea7n ho\u00e0n ch\u1ee7 y\u1ebfu do b\u00e0i ti\u1ebft qua th\u1eadn \u1edf d\u1ea1ng kh\u00f4ng \u0111\u1ed5i. Th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh c\u1ee7a Pregabalin kho\u1ea3ng 6,3 gi\u1edd. Thanh th\u1ea3i Pregabalin huy\u1ebft t\u01b0\u01a1ng v\u00e0 thanh th\u1ea3i th\u1eadn t\u1ec9 l\u1ec7 thu\u1eadn v\u1edbi thanh th\u1ea3i creatinine.<\/p>\n<p>Thanh th\u1ea3i pregabalin gi\u1ea3m \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn.<\/p>\n<p>Pregabalin \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb kh\u1ecfi h\u1ec7 tu\u1ea7n ho\u00e0n ch\u1ee7 y\u1ebfu do b\u00e0i ti\u1ebft qua th\u1eadn \u1edf d\u1ea1ng kh\u00f4ng \u0111\u1ed5i. Th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh c\u1ee7a Pregabalin kho\u1ea3ng 6,3 gi\u1edd. Thanh th\u1ea3i Pregabalin huy\u1ebft t\u01b0\u01a1ng v\u00e0 thanh th\u1ea3i th\u1eadn t\u1ec9 l\u1ec7 thu\u1eadn v\u1edbi thanh th\u1ea3i creatinine.<\/p>\n<p>\u0110i\u1ec1u ch\u1ec9nh li\u1ec1u tr\u00ean c\u00e1c b\u1ec7nh nh\u00e2n gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn ho\u1eb7cth\u1ea9m t\u00e1ch m\u00e1u l\u00e0 c\u1ea7n thi\u1ebft.<\/p>\n<p><em>Tuy\u1ebfn t\u00ednh kh\u00f4ng tuy\u1ebfn t\u00ednh<\/em><\/p>\n<p>D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a Pregabalin l\u00e0 tuy\u1ebfn t\u00ednh trong kho\u1ea3ng li\u1ec1u \u0111\u01a1n h\u1eb1ng ng\u00e0y.<\/p>\n<p>Kho\u1ea3ng bi\u1ebfn thi\u00ean c\u1ee7a d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a Pregabalin th\u1ea5p (&lt; 20%). C\u00e1c \u0111\u1eb7c t\u00ednh d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a li\u1ec1u \u0111\u00e3 c\u00f3 th\u1ec3 d\u1ef1 \u0111o\u00e1n t\u1eeb c\u00e1c d\u1eef li\u1ec7u c\u1ee7a li\u1ec1u \u0111\u01a1n.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"53-giai-thich\"><\/span>5.3 Gi\u1ea3i th\u00edch:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"54-thay-the-thuoc\"><\/span>5.4 Thay th\u1ebf thu\u1ed1c :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h1><span class=\"ez-toc-section\" id=\"6-phan-thong-tin-kem-theo-cua-thuoc\"><\/span>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"61-danh-muc-ta-duoc\"><\/span>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>T\u00e1 d\u01b0\u1ee3c: Starch 1500, Talc, Nang c\u1ee9ng gelatin s\u1ed1 2.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"62-tuong-ky\"><\/span>6.2. T\u01b0\u01a1ng k\u1ef5 :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Kh\u00f4ng \u00e1p d\u1ee5ng.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"63-bao-quan\"><\/span>6.3. B\u1ea3o qu\u1ea3n:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>N\u01a1i kh\u00f4, tr\u00e1nh \u00e1nh s\u00e1ng, nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30\u00b0C.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"64-thong-tin-khac\"><\/span>6.4. Th\u00f4ng tin kh\u00e1c :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Kh\u00f4ng c\u00f3.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"65-tai-lieu-tham-khao\"><\/span>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>HDSD Thu\u1ed1c pendo-Pregabalin 150 mg do C\u00f4ng ty c\u1ed5 ph\u1ea7n xu\u1ea5t nh\u1eadp kh\u1ea9u y t\u1ebf Domesco s\u1ea3n xu\u1ea5t (2017).<\/p>\n<h1><span class=\"ez-toc-section\" id=\"7-nguoi-dang-tai-tac-gia\"><\/span>7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p>B\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c s\u01b0u t\u1ea7m ho\u1eb7c vi\u1ebft b\u1edfi: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-tac-gia-bac-sy-do-my-linh\/\">B\u00e1c s\u0129 nhi khoa &#8211; \u0110\u1ed7 M\u1ef9 Linh.<\/a><\/p>\n<p>Ki\u1ec3m duy\u1ec7t , hi\u1ec7u \u0111\u00ednh v\u00e0 \u0111\u0103ng t\u1ea3i: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-ve-pharmog-team\/\">PHARMOG TEAM<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c pendo-Pregabalin l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c pendo-Pregabalin (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;) 1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Pregabalin (Pregabaline) Ph\u00e2n lo\u1ea1i: Thu\u1ed1c ch\u1ed1ng co gi\u1eadt, [&hellip;]<\/p>\n","protected":false},"author":8612,"featured_media":42233,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[1669],"class_list":["post-42212","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-pregabalin"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/42212","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/8612"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=42212"}],"version-history":[{"count":1,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/42212\/revisions"}],"predecessor-version":[{"id":42250,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/42212\/revisions\/42250"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/42233"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=42212"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=42212"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=42212"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}