{"id":42100,"date":"2022-01-28T11:56:24","date_gmt":"2022-01-28T04:56:24","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=42100"},"modified":"2025-01-07T22:33:02","modified_gmt":"2025-01-07T15:33:02","slug":"pregabalin-brieka","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/","title":{"rendered":"Pregabalin &#8211; Brieka"},"content":{"rendered":"<p><em>Thu\u1ed1c Brieka l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Brieka (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;)<\/em><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_81 ez-toc-wrap-left counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">N\u1ed9i dung ch\u00ednh<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#1-ten-hoat-chat-va-biet-duoc\" >1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#2-dang-bao-che-%e2%80%93-ham-luong\" >2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#3-video-by-pharmog\" >3. Video by Pharmog:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#4-ung-dung-lam-sang\" >4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng:<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#41-chi-dinh\" >4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#42-lieu-dung-%e2%80%93-cach-dung\" >4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#43-chong-chi-dinh\" >4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#44-than-trong\" >4.4 Th\u1eadn tr\u1ecdng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#45-su-dung-cho-phu-nu-co-thai-va-cho-con-bu\" >4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#46-tac-dung-khong-mong-muon-adr\" >4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#47-huong-dan-cach-xu-tri-adr\" >4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#48-tuong-tac-voi-cac-thuoc-khac\" >4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#49-qua-lieu-va-xu-tri\" >4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#5-co-che-tac-dung-cua-thuoc\" >5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#51-duoc-luc-hoc\" >5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#52-duoc-dong-hoc\" >5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#53-giai-thich\" >5.3 Gi\u1ea3i th\u00edch:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#54-thay-the-thuoc\" >5.4 Thay th\u1ebf thu\u1ed1c :<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#6-phan-thong-tin-kem-theo-cua-thuoc\" >6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#61-danh-muc-ta-duoc\" >6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#62-tuong-ky\" >6.2. T\u01b0\u01a1ng k\u1ef5 :<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#63-bao-quan\" >6.3. B\u1ea3o qu\u1ea3n:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#64-thong-tin-khac\" >6.4. Th\u00f4ng tin kh\u00e1c :<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#65-tai-lieu-tham-khao\" >6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/pharmog.com\/wp\/pregabalin-brieka\/#7-nguoi-dang-tai-tac-gia\" >7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<\/a><\/li><\/ul><\/nav><\/div>\n\n<h1><span class=\"ez-toc-section\" id=\"1-ten-hoat-chat-va-biet-duoc\"><\/span>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <\/strong><a href=\"https:\/\/pharmog.com\/wp\/pregabaline\/\"><strong>Pregabalin (Pregabaline)<\/strong><\/a><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u1ed1c ch\u1ed1ng co gi\u1eadt, thu\u1ed1c gi\u1ea3m \u0111au.<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine).<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): N03AX16.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em><\/strong> <a href=\"https:\/\/pharmog.com\/wp\/pregabalin-lyrica\/\">Lyrica<\/a>.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c:<\/em><\/strong> Brieka<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: Balkanpharma &#8211; Dupnitsa AD<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h1><span class=\"ez-toc-section\" id=\"2-dang-bao-che-%e2%80%93-ham-luong\"><\/span>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>Vi\u00ean nang: 75 mg, 150 mg.<\/p>\n<p>Brieka 75mg: Vi\u00ean nang m\u00e0u tr\u1eafng-cam, size 4 (14,5mm), in ch\u1eef \u201cPGB 75\u201d m\u00e0u \u0111en tr\u00ean v\u1ecf nang.<\/p>\n<p>Brieka 150mg: Vi\u00ean nang m\u00e0u tr\u1eafng, size 2 (18mm), in ch\u1eef \u201cPGB 150\u201d m\u00e0u \u0111en tr\u00ean v\u1ecf nang.<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>BRIEKA 75mg<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean nang c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Pregabaline<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>75 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"321\" class=\"wp-image-42113\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2022\/01\/word-image-994.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2022\/01\/word-image-994.png 600w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2022\/01\/word-image-994-300x161.png 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/p>\n<h1><span class=\"ez-toc-section\" id=\"3-video-by-pharmog\"><\/span>3. Video by Pharmog:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<h1><span class=\"ez-toc-section\" id=\"4-ung-dung-lam-sang\"><\/span>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"41-chi-dinh\"><\/span>4.1. Ch\u1ec9 \u0111\u1ecbnh:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>\u0110au th\u1ea7n kinh:<\/em> Brieka \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb \u0111au th\u1ea7n kinh trung \u01b0\u01a1ng v\u00e0 ngo\u1ea1i bi\u00ean \u1edf ng\u01b0\u1eddi l\u1edbn.<\/p>\n<p><em>\u0110\u1ed9ng kinh:<\/em> Brieka \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb b\u1ed5 tr\u1ee3 c\u00e1c c\u01a1n \u0111\u1ed9ng kinh c\u1ee5c b\u1ed9 c\u00f3 ho\u1eb7c kh\u00f4ng c\u00f3 c\u01a1n to\u00e0n th\u1ec3 th\u1ee9 ph\u00e1t \u1edf ng\u01b0\u1eddi l\u1edbn.<\/p>\n<p><em>R\u1ed1i lo\u1ea1n lo \u00e2u to\u00e0n th\u1ec3:<\/em> Brieka \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n lo \u00e2u to\u00e0n th\u1ec3 (GAD) \u1edf ng\u01b0\u1eddi l\u1edbn.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"42-lieu-dung-%e2%80%93-cach-dung\"><\/span>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p>Brieka c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ed3ng th\u1eddi ho\u1eb7c kh\u00f4ng v\u1edbi th\u1ee9c \u0103n.<\/p>\n<p>Brieka ch\u1ec9 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng b\u1eb1ng \u0111\u01b0\u1eddng u\u1ed1ng.<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p>Li\u1ec1u d\u00f9ng: Li\u1ec1u d\u00f9ng t\u1eeb 150 \u0111\u1ebfn 600 mg m\u1ed7i ng\u00e0y, \u0111\u01b0\u1ee3c chia th\u00e0nh hai ho\u1eb7c ba l\u1ea7n.<\/p>\n<p><em>\u0110au th\u1ea7n kinh:<\/em><\/p>\n<p>Pregabalin c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c kh\u1edfi \u0111\u1ea7u v\u1edbi li\u1ec1u 150 mg m\u1ed7i ng\u00e0y \u0111\u01b0\u1ee3c chia th\u00e0nh hai ho\u1eb7c ba l\u1ea7n. D\u1ef1a tr\u00ean \u0111\u00e1p \u1ee9ng v\u00e0 kh\u1ea3 n\u0103ng dung n\u1ea1p c\u1ee7a t\u1eebng b\u1ec7nh nh\u00e2n, c\u00f3 th\u1ec3 t\u0103ng li\u1ec1u l\u00ean \u0111\u1ebfn 300 mg m\u1ed7i ng\u00e0y sau 3-7 ng\u00e0y, v\u00e0 n\u1ebfu c\u1ea7n, t\u0103ng \u0111\u1ebfn li\u1ec1u t\u1ed1i \u0111a 600 mg m\u1ed7i ng\u00e0y sau 7 ng\u00e0y.<\/p>\n<p><em>\u0110\u1ed9ng kinh:<\/em><\/p>\n<p>Pregabalin c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c kh\u1edfi \u0111\u1ea7u v\u1edbi li\u1ec1u 150 mg m\u1ed7i ng\u00e0y chia hai ho\u1eb7c ba l\u1ea7n. D\u1ef1a tr\u00ean \u0111\u00e1p \u1ee9ng v\u00e0 kh\u1ea3 n\u0103ng dung n\u1ea1p c\u1ee7a t\u1eebng b\u1ec7nh nh\u00e2n, li\u1ec1u d\u00f9ng c\u00f3 th\u1ec3 t\u0103ng l\u00ean \u0111\u1ebfn 300 mg m\u1ed7i ng\u00e0y sau 1 tu\u1ea7n. Li\u1ec1u t\u1ed1i \u0111a 600 mg m\u1ed7i ng\u00e0y c\u00f3 th\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c sau m\u1ed9t tu\u1ea7n n\u1eefa.<\/p>\n<p><em>R\u1ed1i lo\u1ea1n lo \u00e2u to\u00e0n th\u1ec3:<\/em><\/p>\n<p>Li\u1ec1u d\u00f9ng t\u1eeb 150 \u0111\u1ebfn 600 mg m\u1ed7i ng\u00e0y \u0111\u01b0\u1ee3c chia th\u00e0nh hai ho\u1eb7c ba l\u1ea7n. Nhu c\u1ea7u \u0111i\u1ec1u tr\u1ecb n\u00ean \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 l\u1ea1i th\u01b0\u1eddng xuy\u00ean.<\/p>\n<p>Pregabalin c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c kh\u1edfi \u0111\u1ea7u v\u1edbi li\u1ec1u 150 mg m\u1ed7i ng\u00e0y. D\u1ef1a tr\u00ean \u0111\u00e1p \u1ee9ng v\u00e0 kh\u1ea3 n\u0103ng dung n\u1ea1p c\u1ee7a t\u1eebng b\u1ec7nh nh\u00e2n, li\u1ec1u d\u00f9ng c\u00f3 th\u1ec3 t\u0103ng l\u00ean \u0111\u1ebfn 300 mg m\u1ed7i ng\u00e0y sau 1 tu\u1ea7n. Tu\u1ea7n sau \u0111\u00f3, c\u00f3 th\u1ec3 t\u0103ng li\u1ec1u l\u00ean \u0111\u1ebfn 450 mg m\u1ed7i ng\u00e0y. Li\u1ec1u t\u1ed1i \u0111a 600 mg m\u1ed7i ng\u00e0y c\u00f3 th\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c sau m\u1ed9t tu\u1ea7n n\u1eefa.<\/p>\n<p><em>Ng\u01b0ng<\/em> <em>pregabalin<\/em>:<\/p>\n<p>Theo th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng hi\u1ec7n nay, n\u1ebfu ng\u01b0ng pregabalin, ng\u01b0\u1eddi ta khuy\u1ebfn c\u00e1o n\u00ean \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n d\u1ea7n d\u1ea7n, t\u1ed1i thi\u1ec3u l\u00e0 1 tu\u1ea7n, kh\u00f4ng ph\u1ee5 thu\u1ed9c v\u00e0o ch\u1ec9 \u0111\u1ecbnh.<\/p>\n<p><em>\u0110\u1ed1i t\u01b0\u1ee3ng \u0111\u1eb7c bi\u1ec7t:<\/em><\/p>\n<p><em>B\u1ec7nh nh\u00e2n suy th\u1eadn:<\/em> Pregabalin \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb kh\u1ecfi h\u1ec7 tu\u1ea7n ho\u00e0n ch\u1ee7 y\u1ebfu do b\u00e0i ti\u1ebft qua th\u1eadn \u1edf d\u1ea1ng kh\u00f4ng \u0111\u1ed5i. V\u00ec \u0111\u1ed9 thanh th\u1ea3i pregabalin t\u1ef7 l\u1ec7 thu\u1eadn v\u1edbi \u0111\u1ed9 thanh th\u1ea3i creatinin, gi\u1ea3m li\u1ec1u \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 ch\u1ee9c n\u0103ng th\u1eadn b\u1ecb t\u1ed5n h\u1ea1i ph\u1ea3i t\u00f9y theo m\u1ed7i b\u1ec7nh nh\u00e2n theo \u0111\u1ed9 thanh th\u1ea3i creatinin (CLcr), \u0111\u01b0\u1ee3c th\u1ec3 hi\u1ec7n trong b\u1ea3ng 1, x\u00e1c \u0111\u1ecbnh b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng c\u00f4ng th\u1ee9c sau \u0111\u00e2y:<\/p>\n<p>CrCl, mL \/ ph\u00fat = (140 \u2013 tu\u1ed5i) \u00d7 (tr\u1ecdng l\u01b0\u1ee3ng, kg) \u00d7 (0,85 n\u1ebfu l\u00e0 n\u1eef) \/ (72 \u00d7 Cr)<\/p>\n<p>Khi l\u1ecdc m\u00e1u pregabalin b\u1ecb lo\u1ea1i tr\u1eeb v\u1edbi t\u1ef7 l\u1ec7 cao t\u1eeb huy\u1ebft t\u01b0\u01a1ng b\u1eb1ng c\u00e1ch l\u1ecdc m\u00e1u (50% thu\u1ed1c trong 4 gi\u1edd). \u0110\u1ed1i v\u1edbi c\u00e1c b\u1ec7nh nh\u00e2n l\u1ecdc m\u00e1u, li\u1ec1u pregabalin h\u00e0ng ng\u00e0y n\u00ean \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh d\u1ef1a tr\u00ean ch\u1ee9c n\u0103ng th\u1eadn. B\u00ean c\u1ea1nh li\u1ec1u h\u00e0ng ng\u00e0y, m\u1ed9t li\u1ec1u b\u1ed5 sung n\u00ean \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ngay l\u1eadp t\u1ee9c m\u1ed7i 4 gi\u1edd sau khi l\u1ecdc m\u00e1u (b\u1ea3ng 1)<\/p>\n<p>&#8211; xem B\u1ea3ng 1.<\/p>\n<table>\n<tbody>\n<tr>\n<td rowspan=\"2\"><strong>\u0110\u1ed9 thanh th\u1ea3i creatinin (ml\/ph\u00fat)<\/strong><\/td>\n<td colspan=\"2\"><strong>T\u1ed5ng li\u1ec1u pregabalin h\u00e0ng ng\u00e0y (*)<\/strong><\/td>\n<td rowspan=\"2\"><strong>Kho\u1ea3ng c\u00e1ch chia li\u1ec1u<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>Li\u1ec1u kh\u1edfi \u0111\u1ea7u (mg\/ng\u00e0y)<\/strong><\/td>\n<td><strong>Li\u1ec1u t\u1ed1i \u0111a (mg\/ng\u00e0y)<\/strong><\/td>\n<\/tr>\n<tr>\n<td>&gt;=60<\/td>\n<td>150<\/td>\n<td>600<\/td>\n<td>2 ho\u1eb7c 3 l\u1ea7n\/ ng\u00e0y<\/td>\n<\/tr>\n<tr>\n<td>30 &#8211; 60<\/td>\n<td>75<\/td>\n<td>300<\/td>\n<td>2 ho\u1eb7c 3 l\u1ea7n\/ ng\u00e0y<\/td>\n<\/tr>\n<tr>\n<td>15 &#8211; 30<\/td>\n<td>25 &#8211; 50<\/td>\n<td>150<\/td>\n<td>1 ho\u1eb7c 2 l\u1ea7n\/ ng\u00e0y<\/td>\n<\/tr>\n<tr>\n<td>&lt; 15<\/td>\n<td>25<\/td>\n<td>75<\/td>\n<td>1 l\u1ea7n\/ ng\u00e0y<\/td>\n<\/tr>\n<tr>\n<td colspan=\"4\">Li\u1ec1u b\u1ed5 sung sau m\u1ed7i 4 gi\u1edd th\u1ea9m ph\u00e2n m\u00e1u<\/td>\n<\/tr>\n<tr>\n<td>.<\/td>\n<td>25<\/td>\n<td>100<\/td>\n<td>M\u1ed9t li\u1ec1u \u0111\u01a1n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><em>S\u1eed d\u1ee5ng \u1edf b\u1ec7nh nh\u00e2n suy gan:<\/em> Kh\u00f4ng c\u1ea7n ch\u1ec9nh li\u1ec1u \u1edf b\u1ec7nh nh\u00e2n suy gan.<\/p>\n<p><em>B\u1ec7nh nhi:<\/em> Hi\u1ec7u l\u1ef1c v\u00e0 \u0111\u1ed9 an to\u00e0n c\u1ee7a Brieka \u1edf tr\u1ebb em d\u01b0\u1edbi 12 tu\u1ed5i v\u00e0 \u1edf thanh thi\u1ebfu ni\u00ean (12-17 tu\u1ed5i) ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c l\u1eadp.<\/p>\n<p><em>S\u1eed d\u1ee5ng \u1edf ng\u01b0\u1eddi l\u1edbn tu\u1ed5i (tr\u00ean 65 tu\u1ed5i):<\/em> B\u1ec7nh nh\u00e2n l\u1edbn tu\u1ed5i c\u00f3 th\u1ec3 c\u1ea7n gi\u1ea3m li\u1ec1u pregabalin do ch\u1ee9c n\u0103ng th\u1eadn gi\u1ea3m.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"43-chong-chi-dinh\"><\/span>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>M\u1eabn c\u1ea3m v\u1edbi ho\u1ea1t ch\u1ea5t ho\u1eb7c v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"44-than-trong\"><\/span>4.4 Th\u1eadn tr\u1ecdng:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>B\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng:<\/em> M\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng, t\u0103ng c\u00e2n do s\u1eed d\u1ee5ng pregabalin th\u00ec c\u1ea7n ph\u1ea3i \u0111i\u1ec1u ch\u1ec9nh c\u00e1c thu\u1ed1c h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft khi \u0111i\u1ec1u tr\u1ecb v\u1edbi pregabalin.<\/p>\n<p><em>Ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn<\/em>: \u0110\u00e3 c\u00f3 c\u00e1c b\u00e1o c\u00e1o v\u1ec1 ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn c\u1ee7a thu\u1ed1c sau khi thu\u1ed1c \u0111\u01b0\u1ee3c l\u01b0u h\u00e0nh, bao g\u1ed3m c\u1ea3 ph\u00f9 m\u1ea1ch. Pregabalin n\u00ean ng\u01b0ng ngay l\u1eadp t\u1ee9c n\u1ebfu x\u1ea3y ra c\u00e1c tri\u1ec7u ch\u1ee9ng ph\u00f9 m\u1ea1ch, nh\u01b0 m\u1eb7t, quanh mi\u1ec7ng, ho\u1eb7c s\u01b0ng \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p tr\u00ean.<\/p>\n<p><em>Ch\u00f3ng m\u1eb7t, bu\u1ed3n ng\u1ee7, m\u1ea5t \u00fd th\u1ee9c, nh\u1ea7m l\u1eabn v\u00e0 suy gi\u1ea3m tinh th\u1ea7n:<\/em> Pregabalin c\u00f3 li\u00ean quan \u0111\u1ebfn ch\u00f3ng m\u1eb7t v\u00e0 bu\u1ed3n ng\u1ee7. C\u0169ng \u0111\u00e3 c\u00f3 c\u00e1c b\u00e1o c\u00e1o v\u1ec1 s\u1ef1 m\u1ea5t \u00fd th\u1ee9c, l\u00fa l\u1eabn v\u00e0 suy gi\u1ea3m tinh th\u1ea7n. Do \u0111\u00f3, b\u1ec7nh nh\u00e2n n\u00ean th\u1eadn tr\u1ecdng cho \u0111\u1ebfn khi h\u1ecd \u0111\u00e3 quen v\u1edbi nh\u1eefng \u1ea3nh h\u01b0\u1edfng ti\u1ec1m \u1ea9n c\u1ee7a thu\u1ed1c.<\/p>\n<p><em>C\u00e1c \u1ea3nh h\u01b0\u1edfng li\u00ean quan \u0111\u1ebfn th\u1ecb gi\u00e1c:<\/em> Trong c\u00e1c th\u1eed nghi\u1ec7m c\u00f3 \u0111\u1ed1i ch\u1ee9ng, m\u1ed9t t\u1ef7 l\u1ec7 cao h\u01a1n b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb v\u1edbi pregabalin \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o gi\u1ea3m th\u1ecb gi\u00e1c so v\u1edbi c\u00e1c b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi gi\u1ea3 d\u01b0\u1ee3c, c\u00e1c tri\u1ec7u ch\u1ee9ng n\u00e0y ph\u1ea7n l\u1edbn t\u1ef1 kh\u1ecfi khi ti\u1ebfp t\u1ee5c \u0111i\u1ec1u tr\u1ecb. Trong c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng t\u1ea1i nh\u00e3n khoa, t\u1ef7 l\u1ec7 gi\u1ea3m th\u1ecb l\u1ef1c v\u00e0 thay \u0111\u1ed5i th\u1ecb tr\u01b0\u1eddng \u1edf c\u00e1c b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi pregabalin l\u00e0 l\u1edbn h\u01a1n so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c, t\u1ef7 l\u1ec7 thay \u0111\u1ed5i v\u00f5ng m\u1ea1c l\u00e0 l\u1edbn h\u01a1n \u1edf b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi gi\u1ea3 d\u01b0\u1ee3c.<\/p>\n<p>C\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i v\u1ec1 th\u1ecb gi\u00e1c c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o sau khi thu\u1ed1c \u0111\u01b0\u1ee3c l\u01b0u h\u00e0nh ra th\u1ecb tr\u01b0\u1eddng, bao g\u1ed3m m\u1ea5t th\u1ecb gi\u00e1c, m\u1edd ho\u1eb7c thay \u0111\u1ed5i th\u1ecb l\u1ef1c, \u0111a s\u1ed1 l\u00e0 tho\u00e1ng qua. Ng\u01b0ng pregabalin c\u00f3 th\u1ec3 l\u00e0m h\u1ed3i ph\u1ee5c ho\u1eb7c c\u1ea3i thi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng v\u1ec1 th\u1ecb gi\u00e1c.<\/p>\n<p><em>Suy th\u1eadn:<\/em> C\u00e1c tr\u01b0\u1eddng h\u1ee3p suy th\u1eadn \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o v\u00e0 trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p ng\u1eebng pregabalin \u0111\u00e3 cho th\u1ea5y ph\u1ee5c h\u1ed3i ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i n\u00e0y.<\/p>\n<p><em>Ng\u1eebng c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh \u0111\u1ed3ng th\u1eddi:<\/em> Kh\u00f4ng \u0111\u1ee7 d\u1eef li\u1ec7u cho th\u1ea5y vi\u1ec7c ng\u1eebng c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh \u0111\u1ed3ng th\u1eddi, khi \u0111\u1ea1t \u0111\u01b0\u1ee3c s\u1ef1 ki\u1ec3m so\u00e1t b\u1ec7nh \u0111\u1ed9ng kinh b\u1eb1ng pregabalin, \u0111\u1ec3 c\u00f3 th\u1ec3 \u0111\u01a1n tr\u1ecb li\u1ec7u v\u1edbi pregabalin.<\/p>\n<p><em>Tri\u1ec7u ch\u1ee9ng ng\u1eebng thu\u1ed1c:<\/em> C\u00e1c tri\u1ec7u ch\u1ee9ng ng\u1eebng thu\u1ed1c sau khi ng\u1eebng \u0111i\u1ec1u tr\u1ecb ng\u1eafn h\u1ea1n v\u00e0 d\u00e0i h\u1ea1n v\u1edbi pregabalin \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn trong m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n. Nh\u1eefng bi\u1ec3u hi\u1ec7n sau \u0111\u00e2y \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111\u1ec1 c\u1eadp: M\u1ea5t ng\u1ee7, nh\u1ee9c \u0111\u1ea7u, bu\u1ed3n n\u00f4n, lo l\u1eafng, ti\u00eau ch\u1ea3y, h\u1ed9i ch\u1ee9ng c\u00fam, c\u0103ng th\u1eb3ng, tr\u1ea7m c\u1ea3m, \u0111au, co gi\u1eadt, t\u0103ng ti\u1ebft m\u1ed3 h\u00f4i v\u00e0 ch\u00f3ng m\u1eb7t, ph\u1ee5 thu\u1ed9c v\u00e0o t\u00ecnh tr\u1ea1ng sinh l\u00fd. B\u1ec7nh nh\u00e2n n\u00ean \u0111\u01b0\u1ee3c th\u00f4ng b\u00e1o \u0111i\u1ec1u n\u00e0y khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>Co gi\u1eadt, bao g\u1ed3m tr\u1ea1ng th\u00e1i \u0111\u1ed9ng kinh, \u0111\u1ed9ng kinh c\u01a1n l\u1edbn, c\u00f3 th\u1ec3 x\u1ea3y ra trong qu\u00e1 tr\u00ecnh s\u1eed d\u1ee5ng pregabalin ho\u1eb7c ngay sau khi ng\u01b0ng pregabalin.<\/p>\n<p>Li\u00ean quan \u0111\u1ebfn ng\u1eebng \u0111i\u1ec1u tr\u1ecb l\u00e2u d\u00e0i c\u1ee7a pregabalin kh\u00f4ng c\u00f3 d\u1eef li\u1ec7u v\u1ec1 t\u1ef7 l\u1ec7 m\u1eafc v\u00e0 m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng c\u1ee7a tri\u1ec7u ch\u1ee9ng ng\u1eebng thu\u1ed1c li\u00ean quan \u0111\u1ebfn th\u1eddi gian v\u00e0 li\u1ec1u s\u1eed d\u1ee5ng c\u1ee7a pregabalin.<\/p>\n<p><em>Suy tim sung huy\u1ebft<\/em>: \u0110\u00e3 c\u00f3 c\u00e1c b\u00e1o c\u00e1o c\u1ee7a suy tim sung huy\u1ebft \u1edf m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb v\u1edbi pregabalin sau khi thu\u1ed1c \u0111\u01b0\u1ee3c l\u01b0u h\u00e0nh. Nh\u1eefng ph\u1ea3n \u1ee9ng n\u00e0y ch\u1ee7 y\u1ebfu \u1edf b\u1ec7nh nh\u00e2n l\u1edbn tu\u1ed5i c\u00f3 t\u1ed5n th\u01b0\u01a1ng tim m\u1ea1ch trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb pregabalin cho ch\u1ec9 \u0111\u1ecbnh \u0111au th\u1ea7n kinh. Pregabalin n\u00ean \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng th\u1eadn tr\u1ecdng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y. Ng\u01b0ng pregabalin c\u00f3 th\u1ec3 gi\u1ea3i quy\u1ebft ph\u1ea3n \u1ee9ng.<\/p>\n<p><em>\u0110i\u1ec1u tr\u1ecb \u0111au th\u1ea7n kinh trung \u01b0\u01a1ng do t\u1ed5n th\u01b0\u01a1ng t\u1ee7y s\u1ed1ng<\/em>: Trong \u0111i\u1ec1u tr\u1ecb \u0111au th\u1ea7n kinh trung \u01b0\u01a1ng do t\u1ed5n th\u01b0\u01a1ng t\u1ee7y s\u1ed1ng, t\u1ef7 l\u1ec7 ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i n\u00f3i chung, c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i tr\u00ean h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng v\u00e0 \u0111\u1eb7c bi\u1ec7t l\u00e0 bu\u1ed3n ng\u1ee7 \u0111\u00e3 t\u0103ng l\u00ean. \u0110i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 l\u00e0 do m\u1ed9t hi\u1ec7u \u1ee9ng ph\u1ee5 do d\u00f9ng \u0111\u1ed3ng th\u1eddi c\u00e1c thu\u1ed1c (v\u00ed d\u1ee5 nh\u01b0 thu\u1ed1c ch\u1ed1ng co th\u1eaft) c\u1ea7n thi\u1ebft cho t\u00ecnh tr\u1ea1ng n\u00e0y. N\u00ean c\u00e2n nh\u1eafc khi ch\u1ec9 \u0111\u1ecbnh pregabalin trong t\u00ecnh tr\u1ea1ng n\u00e0y.<\/p>\n<p><em>\u00dd<\/em> <em>ngh\u0129 v\u00e0 h\u00e0nh vi t\u1ef1 s\u00e1t:<\/em> \u00dd ngh\u0129 v\u00e0 h\u00e0nh vi t\u1ef1 s\u00e1t \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh trong nhi\u1ec1u ch\u1ec9 \u0111\u1ecbnh. M\u1ed9t ph\u00e2n t\u00edch meta c\u1ee7a c\u00e1c nghi\u00ean c\u1ee9u ng\u1eabu nhi\u00ean c\u00f3 \u0111\u1ed1i ch\u1ee9ng v\u1edbi gi\u1ea3 d\u01b0\u1ee3c c\u1ee7a c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh c\u0169ng cho th\u1ea5y c\u00f3 m\u1ed9t t\u1ef7 l\u1ec7 nguy c\u01a1 gia t\u0103ng nh\u1eb9 \u00fd ngh\u0129 v\u00e0 h\u00e0nh vi t\u1ef1 s\u00e1t. C\u01a1 ch\u1ebf c\u1ee7a nguy c\u01a1 n\u00e0y kh\u00f4ng \u0111\u01b0\u1ee3c bi\u1ebft v\u00e0 c\u00e1c d\u1eef li\u1ec7u hi\u1ec7n c\u00f3 kh\u00f4ng lo\u1ea1i tr\u1eeb kh\u1ea3 n\u0103ng gia t\u0103ng nguy c\u01a1 do pregabalin.<\/p>\n<p>V\u00ec v\u1eady b\u1ec7nh nh\u00e2n n\u00ean \u0111\u01b0\u1ee3c theo d\u00f5i c\u00e1c d\u1ea5u hi\u1ec7u c\u1ee7a \u00fd ngh\u0129 v\u00e0 h\u00e0nh vi t\u1ef1 s\u00e1t v\u00e0 n\u00ean c\u00e2n nh\u1eafc \u0111i\u1ec1u tr\u1ecb th\u00edch h\u1ee3p. B\u1ec7nh nh\u00e2n (v\u00e0 nh\u1eefng ng\u01b0\u1eddi ch\u0103m s\u00f3c b\u1ec7nh nh\u00e2n) n\u00ean \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n v\u1ec1 c\u00e1c d\u1ea5u hi\u1ec7u c\u00f3 \u00fd \u0111\u1ecbnh ho\u1eb7c h\u00e0nh vi t\u1ef1 s\u00e1t.<\/p>\n<p><em>Gi\u1ea3m ch\u1ee9c n\u0103ng \u0111\u01b0\u1eddng ti\u00eau h\u00f3a d\u01b0\u1edbi:<\/em> C\u00f3 c\u00e1c b\u00e1o c\u00e1o sau khi thu\u1ed1c \u0111\u01b0\u1ee3c l\u01b0u h\u00e0nh v\u1ec1 c\u00e1c bi\u1ebfn c\u1ed1 li\u00ean quan \u0111\u1ebfn gi\u1ea3m ch\u1ee9c n\u0103ng \u0111\u01b0\u1eddng ti\u00eau h\u00f3a d\u01b0\u1edbi (v\u00ed d\u1ee5, t\u1eafc ru\u1ed9t, li\u1ec7t ru\u1ed9t, t\u00e1o b\u00f3n) khi \u0111i\u1ec1u tr\u1ecb ph\u1ed1i h\u1ee3p pregabalin v\u1edbi c\u00e1c thu\u1ed1c c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y t\u00e1o b\u00f3n, nh\u01b0 thu\u1ed1c gi\u1ea3m \u0111au opioid. Khi s\u1eed d\u1ee5ng k\u1ebft h\u1ee3p pregabalin v\u00e0 opioid n\u00ean xem x\u00e9t c\u00e1c bi\u1ec7n ph\u00e1p ph\u00f2ng ng\u1eeba t\u00e1o b\u00f3n (\u0111\u1eb7c bi\u1ec7t l\u00e0 \u1edf b\u1ec7nh nh\u00e2n n\u1eef v\u00e0 ng\u01b0\u1eddi gi\u00e0).<\/p>\n<p><em>Kh\u1ea3 n\u0103ng l\u1ea1m d\u1ee5ng:<\/em> C\u00e1c tr\u01b0\u1eddng h\u1ee3p l\u1ea1m d\u1ee5ng \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o. C\u1ea7n th\u1eadn tr\u1ecdng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed l\u1ea1m d\u1ee5ng thu\u1ed1c v\u00e0 b\u1ec7nh nh\u00e2n n\u00ean \u0111\u01b0\u1ee3c theo d\u00f5i c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a l\u1ea1m d\u1ee5ng pregabalin (t\u0103ng kh\u1ea3 n\u0103ng dung n\u1ea1p, t\u0103ng li\u1ec1u, c\u00f3 h\u00e0nh vi t\u00ecm thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o).<\/p>\n<p><em>B\u1ec7nh n\u00e3o:<\/em> C\u00e1c tr\u01b0\u1eddng h\u1ee3p b\u1ec7nh n\u00e3o \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o, ch\u1ee7 y\u1ebfu l\u00e0 \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n v\u1edbi \u0111i\u1ec1u ki\u1ec7n c\u01a1 b\u1ea3n m\u00e0 c\u00f3 th\u1ec3 th\u00fac \u0111\u1ea9y b\u1ec7nh l\u00fd n\u00e3o.<\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>Brieka c\u00f3 th\u1ec3 c\u00f3 \u1ea3nh h\u01b0\u1edfng nh\u1eb9 ho\u1eb7c trung b\u00ecnh tr\u00ean kh\u1ea3 n\u0103ng \u0111i\u1ec1u l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c. Brieka c\u00f3 th\u1ec3 g\u00e2y ch\u00f3ng m\u1eb7t v\u00e0 bu\u1ed3n ng\u1ee7 v\u00e0 do \u0111\u00f3 c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c. B\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c khuy\u00ean kh\u00f4ng n\u00ean l\u00e1i xe, v\u1eadn h\u00e0nh m\u00e1y m\u00f3c ph\u1ee9c t\u1ea1p ho\u1eb7c tham gia c\u00e1c ho\u1ea1t \u0111\u1ed9ng nguy hi\u1ec3m kh\u00e1c cho \u0111\u1ebfn khi bi\u1ebft \u0111\u01b0\u1ee3c thu\u1ed1c n\u00e0y c\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng th\u1ef1c hi\u1ec7n c\u00e1c ho\u1ea1t \u0111\u1ed9ng n\u00e0y c\u1ee7a h\u1ecd hay kh\u00f4ng..<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h2><span class=\"ez-toc-section\" id=\"45-su-dung-cho-phu-nu-co-thai-va-cho-con-bu\"><\/span>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: B3<\/p>\n<p>US FDA pregnancy category: C<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>Kh\u00f4ng c\u00f3 \u0111\u1ee7 d\u1eef li\u1ec7u v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng pregabalin \u1edf ph\u1ee5 n\u1eef mang thai.<\/p>\n<p>C\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt \u0111\u00e3 cho th\u1ea5y \u0111\u1ed9c t\u00ednh sinh s\u1ea3n. Nguy c\u01a1 ti\u1ec1m \u1ea9n \u1edf ng\u01b0\u1eddi l\u00e0 kh\u00f4ng r\u00f5.<\/p>\n<p>Brieka kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng trong qu\u00e1 tr\u00ecnh mang thai, ch\u1ec9 n\u00ean d\u00f9ng thu\u1ed1c n\u1ebfu l\u1ee3i \u00edch v\u01b0\u1ee3t tr\u1ed9i nguy c\u01a1.<\/p>\n<p><em>Ph\u1ee5 n\u1eef c\u00f3 kh\u1ea3 n\u0103ng sinh con\/tr\u00e1nh thai \u1edf c\u1ea3 nam v\u00e0 n\u1eef:<\/em><\/p>\n<p>Do ch\u01b0a r\u00f5 nguy c\u01a1 ti\u1ec1m \u1ea9n \u1edf ng\u01b0\u1eddi, ph\u1ea3i s\u1eed d\u1ee5ng bi\u1ec7n ph\u00e1p tr\u00e1nh thai hi\u1ec7u qu\u1ea3 \u1edf ph\u1ee5 n\u1eef c\u00f3 kh\u1ea3 n\u0103ng sinh con.<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>Pregabalin \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9. \u1ea2nh h\u01b0\u1edfng c\u1ee7a pregabalin \u0111\u1ed1i v\u1edbi tr\u1ebb s\u01a1 sinh\/tr\u1ebb nh\u1ecf ch\u01b0a \u0111\u01b0\u1ee3c bi\u1ebft r\u00f5. Vi\u1ec7c quy\u1ebft \u0111\u1ecbnh ng\u1eebng cho con b\u00fa hay ng\u1eebng \u0111i\u1ec1u tr\u1ecb pregabalin c\u1ea7n t\u00ednh \u0111\u1ebfn l\u1ee3i \u00edch c\u1ee7a vi\u1ec7c cho con b\u00fa v\u00e0 l\u1ee3i \u00edch c\u1ee7a vi\u1ec7c \u0111i\u1ec1u tr\u1ecb cho m\u1eb9.<\/p>\n<p><em>Kh\u1ea3 n\u0103ng sinh s\u1ea3n: <\/em><\/p>\n<p>Kh\u00f4ng c\u00f3 d\u1eef li\u1ec7u l\u00e2m s\u00e0ng v\u1ec1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a pregabalin tr\u00ean kh\u1ea3 n\u0103ng sinh s\u1ea3n n\u1eef.<\/p>\n<p>Trong m\u1ed9t th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 hi\u1ec7u qu\u1ea3 c\u1ee7a pregabalin \u0111\u1ed1i v\u1edbi kh\u1ea3 n\u0103ng di \u0111\u1ed9ng c\u1ee7a tinh tr\u00f9ng, \u0111\u1ed1i t\u01b0\u1ee3ng l\u00e0 c\u00e1c b\u1ec7nh nh\u00e2n nam kh\u1ecfe m\u1ea1nh, s\u1eed d\u1ee5ng li\u1ec1u pregabalin l\u00e0 600 mg\/ng\u00e0y. Sau 3 th\u00e1ng \u0111i\u1ec1u tr\u1ecb kh\u00f4ng c\u00f3 \u1ea3nh h\u01b0\u1edfng tr\u00ean kh\u1ea3 n\u0103ng di d\u1ed9ng c\u1ee7a tinh tr\u00f9ng.<\/p>\n<p>M\u1ed9t nghi\u00ean c\u1ee9u sinh s\u1ea3n \u1edf chu\u1ed9t c\u00e1i cho th\u1ea5y t\u00e1c \u0111\u1ed9ng b\u1ea5t l\u1ee3i tr\u00ean sinh s\u1ea3n. Nghi\u00ean c\u1ee9u kh\u1ea3 n\u0103ng sinh s\u1ea3n \u1edf chu\u1ed9t \u0111\u1ef1c c\u0169ng cho th\u1ea5y nh\u1eefng t\u00e1c \u0111\u1ed9ng b\u1ea5t l\u1ee3i tr\u00ean sinh s\u1ea3n v\u00e0 ph\u00e1t tri\u1ec3n. S\u1ef1 li\u00ean quan l\u00e2m s\u00e0ng c\u1ee7a nh\u1eefng t\u00e1c \u0111\u1ed9ng n\u00e0y l\u00e0 ch\u01b0a r\u00f5.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"46-tac-dung-khong-mong-muon-adr\"><\/span>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>C\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i x\u1ea3y ra \u0111\u01b0\u1ee3c li\u1ec7t k\u00ea theo nh\u00f3m v\u00e0 t\u1ea7n su\u1ea5t nh\u01b0 sau: r\u1ea5t th\u01b0\u1eddng g\u1eb7p (ADR \u2265 1\/10), th\u01b0\u1eddng g\u1eb7p (1\/100 \u2264 ADR &lt;1\/10), \u00edt g\u1eb7p (1\/1.000 \u2264 ADR &lt; 1\/100), hi\u1ebfm g\u1eb7p (1\/1.000 \u2264 ADR &lt; 1\/10.000), r\u1ea5t hi\u1ebfm g\u1eb7p (ADR &lt; 1\/10.000), ch\u01b0a r\u00f5 (kh\u00f4ng th\u1ec3 \u01b0\u1edbc t\u00ednh t\u1eeb d\u1eef li\u1ec7u c\u00f3 s\u1eb5n). Trong m\u1ed7i nh\u00f3m, t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n \u0111\u01b0\u1ee3c s\u1eafp x\u1ebfp theo th\u1ee9 t\u1ef1 m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng gi\u1ea3m d\u1ea7n.<\/p>\n<p>C\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i \u0111\u01b0\u1ee3c li\u1ec7t k\u00ea c\u0169ng c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn c\u00e1c b\u1ec7nh ti\u1ec1m \u1ea9n ho\u1eb7c c\u00e1c thu\u1ed1c s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi.<\/p>\n<p>Trong \u0111i\u1ec1u tr\u1ecb \u0111au th\u1ea7n kinh trung \u01b0\u01a1ng do t\u1ed5n th\u01b0\u01a1ng t\u1ee7y s\u1ed1ng, t\u0103ng t\u1ef7 l\u1ec7 ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i n\u00f3i chung, ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i \u1edf h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng v\u00e0 \u0111\u1eb7c bi\u1ec7t l\u00e0 bu\u1ed3n ng\u1ee7.<\/p>\n<p><em>Nhi\u1ec5m tr\u00f9ng v\u00e0 nhi\u1ec5m k\u00fd sinh tr\u00f9ng<\/em><\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p: Vi\u00eam h\u1ecdng<\/p>\n<p><em>R\u1ed1i lo\u1ea1n m\u00e1u v\u00e0 h\u1ec7 b\u1ea1ch huy\u1ebft<\/em><\/p>\n<p>\u00cdt g\u1eb7p: Gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh<\/p>\n<p><em>R\u1ed1i lo\u1ea1n h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch<\/em><\/p>\n<p>\u00cdt g\u1eb7p: Qu\u00e1 m\u1eabn<\/p>\n<p>Hi\u1ebfm g\u1eb7p: Ph\u00f9 m\u1ea1ch, ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng<\/p>\n<p><em>R\u1ed1i lo\u1ea1n chuy\u1ec3n h\u00f3a v\u00e0 dinh d\u01b0\u1ee1ng<\/em><\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p: Th\u00e8m \u0103n<\/p>\n<p>\u00cdt g\u1eb7p: Ch\u00e1n \u0103n, h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft<\/p>\n<p><em>R\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n<\/em><\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p: Tr\u1ea1ng th\u00e1i h\u01b0ng ph\u1ea5n, l\u00fa l\u1eabn, kh\u00f3 ch\u1ecbu, m\u1ea5t ph\u01b0\u01a1ng h\u01b0\u1edbng, m\u1ea5t ng\u1ee7, gi\u1ea3m ham mu\u1ed1n t\u00ecnh d\u1ee5c<\/p>\n<p>\u00cdt g\u1eb7p: \u1ea2o gi\u00e1c, ho\u1ea3ng s\u1ee3, k\u00edch \u0111\u1ed9ng, tr\u1ea7m c\u1ea3m, tinh th\u1ea7n ch\u00e1n n\u1ea3n, tinh th\u1ea7n h\u01b0ng ph\u1ea5n, hung h\u0103ng, thay \u0111\u1ed5i t\u00e2m tr\u1ea1ng, ch\u00e1n n\u1ea3n, kh\u00f3 kh\u0103n trong t\u00ecm ki\u1ebfm t\u1eeb, gi\u1ea5c m\u01a1 b\u1ea5t th\u01b0\u1eddng, t\u0103ng ham mu\u1ed1n t\u00ecnh d\u1ee5c, anorgasmia, th\u1edd \u01a1<\/p>\n<p>Hi\u1ebfm g\u1eb7p: M\u1ea5t tr\u00ed<\/p>\n<p><em>R\u1ed1i lo\u1ea1n h\u1ec7 th\u1ea7n kinh<\/em><\/p>\n<p>R\u1ea5t th\u01b0\u1eddng g\u1eb7p: Ch\u00f3ng m\u1eb7t, bu\u1ed3n ng\u1ee7, \u0111au \u0111\u1ea7u<\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p: M\u1ea5t \u0111i\u1ec1u h\u00f2a, ph\u1ed1i h\u1ee3p b\u1ea5t th\u01b0\u1eddng, run, lo\u1ea1n th\u1ecb, m\u1ea5t tr\u00ed nh\u1edb, suy gi\u1ea3m tr\u00ed nh\u1edb, k\u00e9m ch\u00fa \u00fd, d\u1ecb c\u1ea3m, gi\u1ea3m c\u1ea3m x\u00fac, an th\u1ea7n, r\u1ed1i lo\u1ea1n c\u00e2n b\u1eb1ng, th\u1edd \u01a1<\/p>\n<p>\u00cdt g\u1eb7p: Ng\u1ea5t, co gi\u1eadt, s\u1eefng s\u1edd, t\u0103ng \u0111\u1ed9ng, r\u1ed1i lo\u1ea1n v\u1eadn \u0111\u1ed9ng, ch\u00f3ng m\u1eb7t t\u01b0 th\u1ebf, rung \u0111\u1ed9ng, rung gi\u1eadt nh\u00e3n c\u1ea7u, r\u1ed1i lo\u1ea1n nh\u1eadn th\u1ee9c, suy gi\u1ea3m tinh th\u1ea7n, r\u1ed1i lo\u1ea1n ng\u00f4n ng\u1eef, gi\u1ea3m ph\u1ea3n x\u1ea1, t\u0103ng c\u1ea3m gi\u00e1c, c\u1ea3m gi\u00e1c n\u00f3ng r\u00e1t, m\u1ea5t v\u1ecb gi\u00e1c, kh\u00f3 ch\u1ecbu<\/p>\n<p>Hi\u1ebfm g\u1eb7p: Co gi\u1eadt, lo\u1ea1n kh\u1ee9u gi\u00e1c, gi\u1ea3m kh\u1ea3 n\u0103ng v\u1eadn \u0111\u1ed9ng, dysgraphia<\/p>\n<p><em>R\u1ed1i lo\u1ea1n m\u1eaft<\/em><\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p: Nh\u00ecn m\u1edd, nh\u00ecn \u0111\u00f4i<\/p>\n<p>\u00cdt g\u1eb7p: M\u1ea5t th\u1ecb l\u1ef1c ngo\u1ea1i bi\u00ean, r\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c, s\u01b0ng m\u1eaft, khuy\u1ebft t\u1eadt th\u1ecb tr\u01b0\u1eddng, gi\u1ea3m th\u1ecb l\u1ef1c, \u0111au m\u1eaft, m\u1ecfi m\u1eaft, hoa m\u1eaft, kh\u00f4 m\u1eaft, ch\u1ea3y n\u01b0\u1edbc m\u1eaft, k\u00edch \u1ee9ng m\u1eaft<\/p>\n<p>Hi\u1ebfm g\u1eb7p: M\u1ea5t th\u1ecb l\u1ef1c, vi\u00eam gi\u00e1c m\u1ea1c, nh\u00ecn dao \u0111\u1ed9ng, thay \u0111\u1ed5i nh\u1eadn th\u1ee9c th\u1ecb gi\u00e1c, gi\u00e3n \u0111\u1ed3ng t\u1eed, l\u00e1c m\u1eaft, \u0111\u1ed9 s\u00e1ng th\u1ecb gi\u00e1c<\/p>\n<p><em>R\u1ed1i lo\u1ea1n tai v\u00e0 m\u00ea \u0111\u1ea1o<\/em><\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p: Ch\u00f3ng m\u1eb7t<\/p>\n<p>\u00cdt g\u1eb7p: T\u0103ng nh\u1ea1y c\u1ea3m v\u1edbi \u00e2m thanh<\/p>\n<p><em>R\u1ed1i lo\u1ea1n tim m\u1ea1ch<\/em><\/p>\n<p>\u00cdt g\u1eb7p: Nh\u1ecbp tim nhanh, block nh\u0129 th\u1ea5t \u0111\u1ed9 1, nh\u1ecbp xoang ch\u1eadm, suy tim sung huy\u1ebft<\/p>\n<p>Hi\u1ebfm g\u1eb7p: K\u00e9o d\u00e0i kho\u1ea3ng QT, nh\u1ecbp xoang nhanh, lo\u1ea1n nh\u1ecbp xoang<\/p>\n<p><em>R\u1ed1i lo\u1ea1n m\u1ea1ch m\u00e1u<\/em><\/p>\n<p>\u00cdt g\u1eb7p: H\u1ea1 huy\u1ebft \u00e1p, t\u0103ng huy\u1ebft \u00e1p, n\u00f3ng b\u1eebng, \u0111\u1ecf b\u1eebng, l\u1ea1nh ng\u1eaft<\/p>\n<p><em>R\u1ed1i lo\u1ea1n h\u00f4 h\u1ea5p, ng\u1ef1c, trung th\u1ea5t<\/em><\/p>\n<p>\u00cdt g\u1eb7p: Kh\u00f3 th\u1edf, ch\u1ea3y m\u00e1u cam, ho, ngh\u1eb9t m\u0169i, vi\u00eam m\u0169i, ng\u00e1y, kh\u00f4 m\u0169i<\/p>\n<p>Hi\u1ebfm g\u1eb7p: Ph\u00f9 ph\u1ed5i, t\u1ee9c ng\u1ef1c<\/p>\n<p><em>R\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a<\/em><\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p: N\u00f4n, bu\u1ed3n n\u00f4n, t\u00e1o b\u00f3n, ti\u00eau ch\u1ea3y, \u0111\u1ea7y h\u01a1i, \u0111au b\u1ee5ng, kh\u00f4 mi\u1ec7ng<\/p>\n<p>\u00cdt g\u1eb7p: B\u1ec7nh tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y-th\u1ef1c qu\u1ea3n, t\u0103ng ti\u1ebft n\u01b0\u1edbc b\u1ecdt, gi\u1ea3m c\u1ea3m gi\u00e1c mi\u1ec7ng<\/p>\n<p>Hi\u1ebfm g\u1eb7p: C\u1ed5 tr\u01b0\u1edbng, vi\u00eam t\u1ee5y, l\u01b0\u1ee1i s\u01b0ng, kh\u00f3 nu\u1ed1t<\/p>\n<p><em>R\u1ed1i lo\u1ea1n gan m\u1eadt<\/em><\/p>\n<p>\u00cdt g\u1eb7p: Men gan cao *<\/p>\n<p>Hi\u1ebfm g\u1eb7p: V\u00e0ng da<\/p>\n<p>R\u1ea5t hi\u1ebfm g\u1eb7p: Suy gan, vi\u00eam gan<\/p>\n<p><em>R\u1ed1i lo\u1ea1n da v\u00e0 c\u00e1c m\u00f4 d\u01b0\u1edbi da<\/em><\/p>\n<p>\u00cdt g\u1eb7p: N\u1ed1t ph\u00e1t ban, m\u00e0y \u0111ay, t\u0103ng ti\u1ebft m\u1ed3 h\u00f4i, ng\u1ee9a<\/p>\n<p>Hi\u1ebfm g\u1eb7p: H\u1ed9i ch\u1ee9ng Stevens Johnson, to\u00e1t m\u1ed3 h\u00f4i l\u1ea1nh<\/p>\n<p><em>R\u1ed1i lo\u1ea1n m\u00f4 c\u01a1 x\u01b0\u01a1ng v\u00e0 m\u00f4 li\u00ean k\u1ebft<\/em><\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p: \u0110au c\u01a1, \u0111au kh\u1edbp, \u0111au l\u01b0ng, \u0111au ch\u00e2n tay, co th\u1eaft c\u1ed5 t\u1eed cung<\/p>\n<p>\u00cdt g\u1eb7p: S\u01b0ng kh\u1edbp, \u0111au c\u01a1, co gi\u1eadt, \u0111au c\u1ed5, c\u1ee9ng c\u01a1<\/p>\n<p>Hi\u1ebfm g\u1eb7p: Ti\u00eau c\u01a1 v\u00e2n<\/p>\n<p><em>R\u1ed1i lo\u1ea1n th\u1eadn v\u00e0 ti\u1ebft ni\u1ec7u<\/em><\/p>\n<p>\u00cdt g\u1eb7p: Ti\u1ec3u kh\u00f4ng t\u1ef1 ch\u1ee7, kh\u00f3 ti\u1ec3u<\/p>\n<p>Hi\u1ebfm g\u1eb7p: Suy th\u1eadn, thi\u1ec3u ni\u1ec7u, b\u00ed ti\u1ec3u<\/p>\n<p><em>R\u1ed1i lo\u1ea1n h\u1ec7 th\u1ed1ng sinh s\u1ea3n v\u00e0 v\u00fa<\/em><\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p: R\u1ed1i lo\u1ea1n c\u01b0\u01a1ng d\u01b0\u01a1ng<\/p>\n<p>\u00cdt g\u1eb7p: R\u1ed1i lo\u1ea1n kh\u1ea3 n\u0103ng t\u00ecnh d\u1ee5c, xu\u1ea5t tinh ch\u1eadm, \u0111au b\u1ee5ng kinh, \u0111au v\u00fa<\/p>\n<p>Hi\u1ebfm g\u1eb7p: V\u00f4 kinh, bi\u1ebfn \u0111\u1ed5i h\u00ecnh d\u1ea1ng v\u00fa, ng\u1ef1c n\u1edf, v\u00fa to \u1edf nam<\/p>\n<p><em>R\u1ed1i lo\u1ea1n to\u00e0n th\u00e2n v\u00e0 r\u1ed1i lo\u1ea1n t\u1ea1i v\u1ecb tr\u00ed s\u1eed d\u1ee5ng<\/em><\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p: Ph\u00f9 ngo\u1ea1i vi, ph\u00f9, d\u00e1ng \u0111i b\u1ea5t th\u01b0\u1eddng, ng\u00e3, c\u1ea3m gi\u00e1c say r\u01b0\u1ee3u, c\u1ea3m gi\u00e1c b\u1ea5t th\u01b0\u1eddng, m\u1ec7t m\u1ecfi<\/p>\n<p>\u00cdt g\u1eb7p: Ph\u00f9 to\u00e0n th\u00e2n, ph\u00f9 m\u1eb7t, t\u1ee9c ng\u1ef1c, \u0111au, s\u1ed1t, kh\u00e1t, \u1edbn l\u1ea1nh, suy nh\u01b0\u1ee3c<\/p>\n<p><em>Nghi\u00ean c\u1ee9u<\/em><\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p: T\u0103ng c\u00e2n<\/p>\n<p>\u00cdt g\u1eb7p: T\u0103ng creatine phosphokinase m\u00e1u, t\u0103ng glucose m\u00e1u, gi\u1ea3m s\u1ed1 l\u01b0\u1ee3ng ti\u1ec3u c\u1ea7u, creatinin m\u00e1u t\u0103ng, gi\u1ea3m kali m\u00e1u, gi\u1ea3m c\u00e2n<\/p>\n<p>Hi\u1ebfm g\u1eb7p: Gi\u1ea3m s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u<\/p>\n<p>* T\u0103ng alanine aminotransferase (ALAT) v\u00e0 aspartate aminotransferase (ASAT)<\/p>\n<p>Sau khi ng\u1eebng \u0111i\u1ec1u tr\u1ecb ng\u1eafn h\u1ea1n v\u00e0 d\u00e0i h\u1ea1n v\u1edbi pregabalin c\u00e1c tri\u1ec7u ch\u1ee9ng ng\u1eebng thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn \u1edf m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n. C\u00e1c ph\u1ea3n \u1ee9ng sau \u0111\u00e2y \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111\u1ec1 c\u1eadp: M\u1ea5t ng\u1ee7, nh\u1ee9c \u0111\u1ea7u, bu\u1ed3n n\u00f4n, lo l\u1eafng, ti\u00eau ch\u1ea3y, h\u1ed9i ch\u1ee9ng c\u00fam, co gi\u1eadt, c\u0103ng th\u1eb3ng, tr\u1ea7m c\u1ea3m, \u0111au, t\u0103ng ti\u1ebft m\u1ed3 h\u00f4i v\u00e0 ch\u00f3ng m\u1eb7t. B\u1ec7nh nh\u00e2n n\u00ean \u0111\u01b0\u1ee3c th\u00f4ng b\u00e1o v\u1ec1 \u0111i\u1ec1u n\u00e0y khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>Li\u00ean quan \u0111\u1ebfn vi\u1ec7c ng\u1eebng \u0111i\u1ec1u tr\u1ecb l\u00e2u d\u00e0i c\u1ee7a pregabalin, kh\u00f4ng c\u00f3 d\u1eef li\u1ec7u v\u1ec1 t\u1ef7 l\u1ec7 m\u1eafc v\u00e0 m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng c\u1ee7a tri\u1ec7u ch\u1ee9ng ng\u1eebng thu\u1ed1c li\u00ean quan \u0111\u1ebfn th\u1eddi gian s\u1eed d\u1ee5ng v\u00e0 li\u1ec1u l\u01b0\u1ee3ng c\u1ee7a pregabalin.<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<h2><span class=\"ez-toc-section\" id=\"47-huong-dan-cach-xu-tri-adr\"><\/span>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>M\u1ed9t s\u1ed1 ADR l\u00e0m ng\u01b0\u1eddi b\u1ec7nh ph\u1ea3i ng\u1eebng thu\u1ed1c. 4% ng\u01b0\u1eddi b\u1ec7nh b\u1ecb ch\u00f3ng m\u1eb7t ho\u1eb7c bu\u1ed3n ng\u1ee7 ph\u1ea3i ng\u1eebng \u0111i\u1ec1u tr\u1ecb. \u0110a s\u1ed1 c\u00e1c tr\u01b0\u1eddng h\u1ee3p b\u1ecb nh\u00ecn m\u1edd t\u1ef1 h\u1ebft khi ti\u1ebfp t\u1ee5c \u0111i\u1ec1u tr\u1ecb, d\u01b0\u1edbi 1% ng\u01b0\u1eddi b\u1ec7nh ph\u1ea3i ng\u1eebng \u0111i\u1ec1u tr\u1ecb. N\u1ebfu r\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c k\u00e9o d\u00e0i, c\u1ea7n cho th\u0103m kh\u00e1m m\u1eaft.<\/p>\n<p>Ph\u1ea3i ng\u1eebng thu\u1ed1c khi b\u1ecb b\u1ec7nh c\u01a1, ho\u1eb7c khi th\u1ea5y n\u1ed3ng \u0111\u1ed9 CPK huy\u1ebft thanh t\u0103ng cao \u00edt nh\u1ea5t g\u1ea5p 3 l\u1ea7n m\u1ee9c cao c\u1ee7a gi\u1edbi h\u1ea1n b\u00ecnh th\u01b0\u1eddng. Ph\u1ea3i ng\u1eebng thu\u1ed1c khi c\u00f3 t\u0103ng c\u00e2n, ph\u00f9 ngo\u1ea1i bi\u00ean \u1edf ng\u01b0\u1eddi \u0111\u00e3 c\u00f3 b\u1ec7nh tim t\u1eeb tr\u01b0\u1edbc.<\/p>\n<p>Ph\u00f9 m\u1ea1ch tuy hi\u1ebfm x\u1ea3y ra nh\u01b0ng th\u01b0\u1eddng x\u1ea3y ra ngay khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb pregabalin; do \u0111\u00f3, tr\u01b0\u1edbc khi cho b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb b\u1eb1ng pregabalin, c\u1ea7n h\u1ecfi k\u1ef9 ti\u1ec1n s\u1eed m\u1eabn c\u1ea3m v\u00e0 chu\u1ea5n b\u1ecb ph\u01b0\u01a1ng ti\u1ec7n c\u1ea5p c\u1ee9u th\u00edch h\u1ee3p.<\/p>\n<p>Ngo\u00e0i ra, c\u1ea7n th\u00f4ng b\u00e1o cho ng\u01b0\u1eddi b\u1ec7nh v\u00e0 gia \u0111\u00ecnh bi\u1ebft v\u1ec1 ti\u1ec1m n\u0103ng nguy c\u01a1 t\u1ef1 s\u00e1t khi d\u00f9ng thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh. Ph\u1ea3i ch\u00fa \u00fd \u0111\u1ebfn c\u00e1c tri\u1ec7u ch\u1ee9ng b\u00e1o hi\u1ec7u nh\u01b0 lo \u00e2u, v\u1eadt v\u00e3, hung h\u00e3n, t\u1ea5n c\u00f4ng, ch\u1ed1ng \u0111\u1ed1i, thao cu\u1ed3ng, m\u1ea5t ng\u1ee7 v\u00e0 tr\u1ea7m c\u1ea3m. Gia \u0111\u00ecnh c\u1ea7n theo d\u00f5i s\u00e1t ng\u01b0\u1eddi b\u1ec7nh.<\/p>\n<p>Khi ng\u1eebng thu\u1ed1c, tr\u00e1nh ng\u1eebng \u0111\u1ed9t ng\u1ed9t, gi\u1ea3m d\u1ea7n li\u1ec1u trong kho\u1ea3ng \u00edt nh\u1ea5t m\u1ed9t tu\u1ea7n.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"48-tuong-tac-voi-cac-thuoc-khac\"><\/span>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Do pregabalin ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft trong n\u01b0\u1edbc ti\u1ec3u \u1edf d\u1ea1ng kh\u00f4ng \u0111\u1ed5i, qua qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a kh\u00f4ng \u0111\u00e1ng k\u1ec3 \u1edf ng\u01b0\u1eddi (&lt; 2% li\u1ec1u thu h\u1ed3i trong n\u01b0\u1edbc ti\u1ec3u l\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a), kh\u00f4ng \u1ee9c ch\u1ebf chuy\u1ec3n h\u00f3a thu\u1ed1c in vitro, v\u00e0 kh\u00f4ng g\u1eafn k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng, n\u00ean n\u00f3 \u00edt c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y ra, ho\u1eb7c l\u00e0 m\u1ee5c ti\u00eau c\u1ee7a c\u00e1c t\u01b0\u01a1ng t\u00e1c d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc.<\/p>\n<p><em>Trong c\u00e1c nghi\u00ean c\u1ee9u in vivo v\u00e0 \u0111\u1ed1i t\u01b0\u1ee3ng ph\u00e2n t\u00edch d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/em><\/p>\n<p>Theo \u0111\u00f3, trong nghi\u00ean c\u1ee9u in vivo kh\u00f4ng c\u00f3 t\u01b0\u01a1ng t\u00e1c d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc li\u00ean quan v\u1ec1 l\u00e2m s\u00e0ng \u0111\u01b0\u1ee3c ghi nh\u1eadn gi\u1eefa pregabalin v\u00e0 phenytoin, carbamazepin, valproic acid, lamotrigine, gabapentin, lorazepam, oxycodone hay ethanol. \u0110\u1ed1i t\u01b0\u1ee3ng ph\u00e2n t\u00edch d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc cho th\u1ea5y thu\u1ed1c \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng \u0111\u01b0\u1eddng u\u1ed1ng, thu\u1ed1c l\u1ee3i ti\u1ec3u, insulin, phenobarbital, tiagabine v\u00e0 topiramate kh\u00f4ng c\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng tr\u00ean \u0111\u1ed9 thanh th\u1ea3i pregabalin.<\/p>\n<p><em>Thu\u1ed1c tr\u00e1nh thai u\u1ed1ng, norethisterone v\u00e0\/ho\u1eb7c ethinyl estradiol:<\/em><\/p>\n<p>D\u00f9ng \u0111\u1ed3ng th\u1eddi pregabalin v\u1edbi c\u00e1c thu\u1ed1c tr\u00e1nh thai u\u1ed1ng norethisterone v\u00e0\/ho\u1eb7c ethinyl estradiol kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh c\u1ee7a m\u1ed7i thu\u1ed1c n\u00e0y.<\/p>\n<p><em>\u1ea2nh h\u01b0\u1edfng c\u1ee7a thu\u1ed1c v\u1edbi h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng:<\/em><\/p>\n<p>Pregabalin c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng c\u1ee7a ethanol v\u00e0 lorazepam. Trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng c\u00f3 \u0111\u1ed1i ch\u1ee9ng, li\u1ec1u u\u1ed1ng nhi\u1ec1u l\u1ea7n pregabalin \u0111\u1ed3ng th\u1eddi v\u1edbi oxycodone, lorazepam, ho\u1eb7c ethanol kh\u00f4ng d\u1eabn \u0111\u1ebfn nh\u1eefng \u1ea3nh h\u01b0\u1edfng quan tr\u1ecdng v\u1ec1 l\u00e2m s\u00e0ng tr\u00ean h\u00f4 h\u1ea5p. Theo kinh nghi\u1ec7m sau khi thu\u1ed1c \u0111\u01b0\u1ee3c l\u01b0u h\u00e0nh ra th\u1ecb tr\u01b0\u1eddng, c\u00f3 c\u00e1c b\u00e1o c\u00e1o v\u1ec1 suy h\u00f4 h\u1ea5p v\u00e0 h\u00f4n m\u00ea \u1edf b\u1ec7nh nh\u00e2n d\u00f9ng pregabalin v\u00e0 c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng kh\u00e1c. Pregabalin d\u01b0\u1eddng nh\u01b0 l\u00e0m t\u0103ng s\u1ef1 gi\u1ea3m nh\u1eadn th\u1ee9c v\u00e0 ch\u1ee9c n\u0103ng v\u1eadn \u0111\u1ed9ng n\u00f3i chung g\u00e2y ra b\u1edfi oxycodone.<\/p>\n<p><em>Ng\u01b0\u1eddi gi\u00e0:<\/em><\/p>\n<p>Kh\u00f4ng c\u00f3 nghi\u00ean c\u1ee9u t\u01b0\u01a1ng t\u00e1c d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee5 th\u1ec3 n\u00e0o \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh \u1edf nh\u1eefng ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n cao tu\u1ed5i. C\u00e1c nghi\u00ean c\u1ee9u t\u01b0\u01a1ng t\u00e1c ch\u1ec9 th\u1ef1c hi\u1ec7n \u1edf ng\u01b0\u1eddi l\u1edbn.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"49-qua-lieu-va-xu-tri\"><\/span>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Trong c\u00e1c kinh nghi\u1ec7m sau khi thu\u1ed1c \u0111\u01b0\u1ee3c \u0111\u01b0a l\u01b0u h\u00e0nh tr\u00ean th\u1ecb tr\u01b0\u1eddng, c\u00e1c ph\u1ea3n \u1ee9ng ph\u1ee5 th\u01b0\u1eddng g\u1eb7p nh\u1ea5t \u0111\u01b0\u1ee3c ghi nh\u1eadn khi s\u1eed d\u1ee5ng qu\u00e1 li\u1ec1u pregabalin bao g\u1ed3m bu\u1ed3n ng\u1ee7, tr\u1ea1ng th\u00e1i l\u00fa l\u1eabn, k\u00edch \u0111\u1ed9ng, v\u00e0 b\u1ed3n ch\u1ed3n.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb qu\u00e1 li\u1ec1u pregabalin bao g\u1ed3m c\u00e1c bi\u1ec7n ph\u00e1p h\u1ed7 tr\u1ee3 v\u00e0 c\u00f3 th\u1ec3 ch\u1ea1y th\u1eadn nh\u00e2n t\u1ea1o n\u1ebfu c\u1ea7n.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h1><span class=\"ez-toc-section\" id=\"5-co-che-tac-dung-cua-thuoc\"><\/span>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"51-duoc-luc-hoc\"><\/span>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Nh\u00f3m d\u01b0\u1ee3c l\u00fd: Thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh, m\u00e3 ATC: N03AX16<\/p>\n<p>Pregabalin c\u00f3 c\u1ea5u tr\u00fac t\u01b0\u01a1ng t\u1ef1 gamma aminobutyric acid ((S)-3- (aminomethyl)- 5- axit methylhexanoic).<\/p>\n<p><em>C\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng:<\/em> Pregabalin li\u00ean k\u1ebft v\u1edbi m\u1ed9t ti\u1ec3u \u0111\u01a1n v\u1ecb ph\u1ee5 (\u03b12-\u03b4 protein) c\u1ee7a k\u00eanh canxi ph\u1ee5 thu\u1ed1c \u0111i\u1ec7n th\u1ebf trong h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng, c\u00f3 th\u1ec3 thay [3H]-gabapentin.<\/p>\n<p><em>\u0110au th\u1ea7n kinh<\/em><\/p>\n<p>Hi\u1ec7u qu\u1ea3 \u0111\u01b0\u1ee3c th\u1ec3 hi\u1ec7n trong c\u00e1c nghi\u00ean c\u1ee9u tr\u00ean c\u00e1c b\u1ec7nh nh\u00e2n b\u1ecb b\u1ec7nh th\u1ea7n kinh do \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng, \u0111au d\u00e2y th\u1ea7n kinh sau zona v\u00e0 t\u1ed5n th\u01b0\u01a1ng t\u1ee7y s\u1ed1ng. Hi\u1ec7u qu\u1ea3 ch\u01b0a \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u trong c\u00e1c m\u00f4 h\u00ecnh \u0111au th\u1ea7n kinh kh\u00e1c.<\/p>\n<p>Pregabalin \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u trong 10 th\u1eed nghi\u00eam l\u00e2m s\u00e0ng c\u00f3 \u0111\u1ed1i ch\u1ee9ng l\u00ean \u0111\u1ebfn 13 tu\u1ea7n v\u1edbi li\u1ec1u l\u00e0 2 l\u1ea7n\/ng\u00e0y (BID) v\u00e0 l\u00ean \u0111\u1ebfn 8 tu\u1ea7n v\u1edbi li\u1ec1u 3 l\u1ea7n\/ng\u00e0y (TID). Nh\u00ecn chung, t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 cho ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb BID v\u00e0 TID l\u00e0 t\u01b0\u01a1ng t\u1ef1 nhau.<\/p>\n<p>Trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng l\u00ean \u0111\u1ebfn 12 tu\u1ea7n cho c\u1ea3 \u0111au ngo\u1ea1i vi v\u00e0 \u0111au th\u1ea7n kinh trung \u01b0\u01a1ng. S\u1ef1 gi\u1ea3m c\u01a1n \u0111au \u0111\u01b0\u1ee3c nh\u00ecn th\u1ea5y trong 1 tu\u1ea7n v\u00e0 trong su\u1ed1t th\u1eddi gian \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>Trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng c\u00f3 \u0111\u1ed1i ch\u1ee9ng \u0111\u1ed1i v\u1edbi c\u00e1c b\u1ec7nh nh\u00e2n \u0111au th\u1ea7n kinh ngo\u1ea1i bi\u00ean 35% b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng pregabalin v\u00e0 18% b\u1ec7nh nh\u00e2n d\u00f9ng gi\u1ea3 d\u01b0\u1ee3c \u0111\u00e3 c\u1ea3i thi\u1ec7n 50% \u0111i\u1ec3m s\u1ed1 \u0111au. \u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n kh\u00f4ng c\u00f3 c\u1ea3m gi\u00e1c bu\u1ed3n ng\u1ee7, s\u1ef1 c\u1ea3i thi\u1ec7n n\u00e0y \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y \u1edf 33% b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng pregabalin v\u00e0 18% b\u1ec7nh nh\u00e2n d\u00f9ng gi\u1ea3 d\u01b0\u1ee3c. \u0110\u1ed1i v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 c\u1ea3m gi\u00e1c bu\u1ed3n ng\u1ee7, t\u1ef7 l\u1ec7 \u0111\u00e1p \u1ee9ng l\u00e0 48% \u0111\u1ed1i v\u1edbi pregabalin v\u00e0 16% \u0111\u1ed1i v\u1edbi gi\u1ea3 d\u01b0\u1ee3c.<\/p>\n<p>Trong th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng c\u00f3 \u0111\u1ed1i ch\u1ee9ng \u0111\u1ed1i v\u1edbi c\u00e1c b\u1ec7nh nh\u00e2n \u0111au th\u1ea7n kinh trung \u01b0\u01a1ng 22% b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb pregabalin v\u00e0 7% b\u1ec7nh nh\u00e2n d\u00f9ng gi\u1ea3 d\u01b0\u1ee3c \u0111\u00e3 c\u1ea3i thi\u1ec7n 50% \u0111i\u1ec3m s\u1ed1 \u0111au.<\/p>\n<p><em>B\u1ec7nh \u0111\u1ed9ng kinh<\/em><\/p>\n<p>\u0110i\u1ec1u tr\u1ecb b\u1ed5 tr\u1ee3.<\/p>\n<p>Pregabalin \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u trong 3 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng c\u00f3 \u0111\u1ed1i ch\u1ee9ng trong 12 tu\u1ea7n v\u1edbi li\u1ec1u BID ho\u1eb7c TID. Nh\u00ecn chung t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 cho hai ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb n\u00e0y l\u00e0 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng nhau.Vi\u1ec7c gi\u1ea3m t\u1ea7n su\u1ea5t co gi\u1eadt \u0111\u01b0\u1ee3c quan s\u00e1t v\u00e0o tu\u1ea7n 1.<\/p>\n<p><em>\u0110\u1ed1i t\u01b0\u1ee3ng tr\u1ebb em<\/em><\/p>\n<p>Hi\u1ec7u qu\u1ea3 v\u00e0 an to\u00e0n c\u1ee7a pregabalin nh\u01b0 m\u1ed9t li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb b\u1ed5 tr\u1ee3 b\u1ec7nh \u0111\u1ed9ng kinh \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n nhi d\u01b0\u1edbi 12 tu\u1ed5i v\u00e0 thanh thi\u1ebfu ni\u00ean ch\u01b0a \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp. C\u00e1c bi\u1ec3u hi\u1ec7n b\u1ea5t l\u1ee3i quan s\u00e1t \u0111\u01b0\u1ee3c trong m\u1ed9t nghi\u00ean c\u1ee9u d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc v\u00e0 kh\u1ea3 n\u0103ng dung n\u1ea1p tr\u00ean b\u1ec7nh nh\u00e2n t\u1eeb 3 th\u00e1ng \u0111\u1ebfn 16 tu\u1ed5i (n = 65) v\u1edbi kh\u1edfi ph\u00e1t c\u01a1n \u0111\u1ed9ng kinh c\u1ee5c b\u1ed9 t\u01b0\u01a1ng t\u1ef1 nh\u01b0 quan s\u00e1t tr\u00ean ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh. K\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u \u0111\u1ed1i ch\u1ee9ng v\u1edbi gi\u1ea3 d\u01b0\u1ee3c trong 12 tu\u1ea7n c\u1ee7a 295 b\u1ec7nh nh\u00e2n nhi t\u1eeb 4 \u0111\u1ebfn 16 tu\u1ed5i v\u00e0 nghi\u00ean c\u1ee9u an to\u00e0n, bi\u1ebft r\u00f5 t\u00ean thu\u1ed1c trong 1 n\u0103m \u1edf 54 b\u1ec7nh nh\u00e2n nhi t\u1eeb 3 th\u00e1ng \u0111\u1ebfn 16 tu\u1ed5i v\u1edbi ch\u1ec9 \u0111\u1ecbnh \u0111\u1ed9ng kinh cho th\u1ea5y c\u00e1c ph\u1ea3n \u1ee9ng ph\u1ee5 nh\u01b0 s\u1ed1t r\u00e9t v\u00e0 nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p tr\u00ean \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y th\u01b0\u1eddng g\u1eb7p h\u01a1n so v\u1edbi c\u00e1c nghi\u00ean c\u1ee9u \u1edf ng\u01b0\u1eddi l\u1edbn b\u1ecb b\u1ec7nh \u0111\u1ed9ng kinh.<\/p>\n<p>Trong nghi\u00ean c\u1ee9u 12 tu\u1ea7n c\u00f3 \u0111\u1ed1i ch\u1ee9ng v\u1edbi gi\u1ea3 d\u01b0\u1ee3c, b\u1ec7nh nh\u00e2n nhi \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh d\u00f9ng pregabalin 2,5 mg\/kg\/ng\u00e0y (t\u1ed1i \u0111a 150 mg\/ng\u00e0y), pregabalin 10 mg\/kg\/ng\u00e0y (t\u1ed1i \u0111a 600 mg\/ng\u00e0y), ho\u1eb7c gi\u1ea3 d\u01b0\u1ee3c. T\u1ef7 l\u1ec7 s\u1ed1 b\u1ec7nh nh\u00e2n gi\u1ea3m \u00edt nh\u1ea5t 50% s\u1ed1 l\u1ea7n kh\u1edfi ph\u00e1t \u0111\u1ed9ng kinh c\u1ee5c b\u1ed9 so v\u1edbi \u0111\u01b0\u1eddng n\u1ec1n l\u00e0 40,6% b\u1ec7nh nh\u00e2n trong nh\u00f3m \u0111i\u1ec1u tr\u1ecb v\u1edbi pregabalin v\u00e0 10 mg\/kg\/ng\u00e0y (p = 0,006 so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c); 29,1% b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb b\u1eb1ng pregabalin 2,5 mg\/kg\/ng\u00e0y (p = 0,2600 so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c) v\u00e0 22,6% b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng gi\u1ea3 d\u01b0\u1ee3c.<\/p>\n<p><em>\u0110\u01a1n tr\u1ecb li\u1ec7u (v\u1edbi b\u1ec7nh nh\u00e2n m\u1edbi \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n)<\/em><\/p>\n<p>Pregabalin \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u trong 1 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng c\u00f3 \u0111\u1ed1i ch\u1ee9ng trong th\u1eddi gian 56 tu\u1ea7n v\u1edbi li\u1ec1u BID. Pregabalin kh\u00f4ng \u0111\u1ea1t \u0111\u01b0\u1ee3c k\u1ebft qu\u1ea3 k\u00e9m h\u01a1n so v\u1edbi lamotrigine d\u1ef1a tr\u00ean c\u00e1c ch\u1ec9 ti\u00eau l\u00e2m s\u00e0ng thu \u0111\u01b0\u1ee3c trong 6 th\u00e1ng. Pregabalin v\u00e0 lamotrigine t\u01b0\u01a1ng t\u1ef1 v\u1ec1 an to\u00e0n v\u00e0 dung n\u1ea1p t\u1ed1t.<\/p>\n<p><em>R\u1ed1i lo\u1ea1n lo \u00e2u to\u00e0n th\u1ec3<\/em><\/p>\n<p>Pregabalin \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u trong 6 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng c\u00f3 \u0111\u1ed1i ch\u1ee9ng trong th\u1eddi gian 4-6 tu\u1ea7n, m\u1ed9t nghi\u00ean c\u1ee9u tr\u00ean ng\u01b0\u1eddi gi\u00e0 trong th\u1eddi gian 8 tu\u1ea7n v\u00e0 m\u1ed9t nghi\u00ean c\u1ee9u m\u00f9 \u0111\u00f4i d\u1ef1 ph\u00f2ng t\u00e1i ph\u00e1t d\u00e0i h\u1ea1n v\u1edbi giai \u0111o\u1ea1n d\u1ef1 ph\u00f2ng t\u00e1i ph\u00e1t trong 6 th\u00e1ng.<\/p>\n<p>Bi\u1ec3u hi\u1ec7n tri\u1ec7u ch\u1ee9ng c\u1ee7a r\u1ed1i lo\u1ea1n lo \u00e2u to\u00e0n th\u1ec3 \u0111\u01b0\u1ee3c ph\u1ea3n \u00e1nh b\u1edfi Hamilton Anxiety Rating Scale (HAM-A) quan s\u00e1t \u1edf tu\u1ea7n 1.<\/p>\n<p>Trong nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng c\u00f3 \u0111\u1ed1i ch\u1ee9ng (th\u1eddi gian 4-8 tu\u1ea7n) 2% b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb pregabalin v\u00e0 38% b\u1ec7nh nh\u00e2n d\u00f9ng gi\u1ea3 d\u01b0\u1ee3c c\u00f3 \u00edt nh\u1ea5t 50% c\u1ea3i thi\u1ec7n t\u1ed5ng \u0111i\u1ec3m HAM-A t\u1eeb l\u00fac b\u1eaft \u0111\u1ea7u \u0111\u1ebfn k\u1ebft th\u00fac.<\/p>\n<p>Trong c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng c\u00f3 \u0111\u1ed1i ch\u1ee9ng, m\u1ed9t t\u1ef7 l\u1ec7 cao h\u01a1n \u1edf c\u00e1c b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng pregabalin b\u00e1o c\u00e1o nh\u00ecn m\u1edd h\u01a1n so v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n d\u00f9ng gi\u1ea3 d\u01b0\u1ee3c \u0111\u00e3 \u0111\u01b0\u1ee3c gi\u1ea3i quy\u1ebft trong ph\u1ea7n l\u1edbn c\u00e1c b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng li\u1ec1u li\u00ean t\u1ee5c. Ophthamologic testing (bao g\u1ed3m ki\u1ec3m tra th\u1ecb l\u1ef1c, ki\u1ec3m tra th\u1ecb tr\u01b0\u1eddng, ki\u1ec3m tra gi\u00e3n n\u1edf n\u1ed9i soi) \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh \u1edf h\u01a1n 3600 b\u1ec7nh nh\u00e2n trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng c\u00f3 \u0111\u1ed1i ch\u1ee9ng. \u1ede nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y, th\u1ecb l\u1ef1c gi\u1ea3m 6,5% \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng pregabalin v\u00e0 4,8% b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng gi\u1ea3 d\u01b0\u1ee3c. 12,4% \u0111i\u1ec1u tr\u1ecb b\u1eb1ng pregabalin v\u00e0 11,7% b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng gi\u1ea3 d\u01b0\u1ee3c c\u00f3 nh\u1eefng thay \u0111\u1ed5i v\u1ec1 th\u1ecb tr\u01b0\u1eddng. 1,7% \u0111i\u1ec1u tr\u1ecb b\u1eb1ng pregabalin v\u00e0 2,1% b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng gi\u1ea3 d\u01b0\u1ee3c quan s\u00e1t c\u00f3 nh\u1eefng thay \u0111\u1ed5i gi\u00e3n n\u1edf khi n\u1ed9i soi.<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>Pregabalin g\u1eafn v\u1edbi 1 ti\u1ec3u \u0111\u01a1n v\u1ecb ph\u1ee5 (\u03b1<sub>2<\/sub>&#8211; \u03b4 protein) c\u1ee7a k\u00eanh calci c\u1ed5ng \u0111i\u1ec7n th\u1ebf trong h\u1ec7 th\u1ed1ng th\u1ea7n kinh trung \u01b0\u01a1ng.<\/p>\n<p>B\u1eb1ng ch\u1ee9ng t\u1eeb m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt c\u00f3 t\u1ed5n th\u01b0\u01a1ng th\u1ea7n kinh ch\u1ec9 ra r\u1eb1ng pregabalin gi\u1ea3m gi\u1ea3i ph\u00f3ng ch\u1ea5t d\u1eabn truy\u1ec1n th\u1ea7n kinh c\u1ea3m th\u1ee5 \u0111au ph\u1ee5 thu\u1ed9c v\u00e0o canxi \u1edf t\u1ee7y s\u1ed1ng, c\u00f3 th\u1ec3 th\u00f4ng qua s\u1ef1 ng\u0103n c\u1ea3n v\u1eadn chuy\u1ec3n canxi v\u00e0\/ho\u1eb7c gi\u1ea3m d\u00f2ng canxi. B\u1eb1ng ch\u1ee9ng t\u1eeb c\u00e1c m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt kh\u00e1c c\u00f3 t\u1ed5n th\u01b0\u01a1ng th\u1ea7n kinh cho th\u1ea5y ho\u1ea1t t\u00ednh gi\u1ea3m \u0111au c\u1ee7a pregabalin c\u0169ng c\u00f3 th\u1ec3 gi\u00e1n ti\u1ebfp qua c\u00e1c t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c con \u0111\u01b0\u1eddng ph\u00f3 giao c\u1ea3m v\u00e0 serotonin.<\/p>\n<p><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/p>\n<h2><span class=\"ez-toc-section\" id=\"52-duoc-dong-hoc\"><\/span>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a pregabalin \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh l\u00e0 nh\u01b0 nhau \u1edf ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n kh\u1ecfe m\u1ea1nh, b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh v\u00e0 b\u1ec7nh nh\u00e2n b\u1ecb \u0111au m\u1ea1n t\u00ednh.<\/p>\n<p><em>H\u1ea5p thu:<\/em> Pregabalin \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh ch\u00f3ng khi \u0111\u00f3i, v\u1edbi n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t \u0111\u01b0\u1ee3c trong v\u00f2ng 1 gi\u1edd sau khi s\u1eed d\u1ee5ng c\u1ea3 li\u1ec1u \u0111\u01a1n v\u00e0 \u0111a li\u1ec1u. Sinh kh\u1ea3 d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng c\u1ee7a pregabalin \u0111\u01b0\u1ee3c \u01b0\u1edbc t\u00ednh l\u00e0 90% v\u00e0 kh\u00f4ng ph\u1ee5 thu\u1ed9c v\u00e0o li\u1ec1u d\u00f9ng. Sau khi d\u00f9ng li\u1ec1u l\u1eb7p l\u1ea1i, tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh \u0111\u1ea1t \u0111\u01b0\u1ee3c trong v\u00f2ng 24 \u0111\u1ebfn 48 gi\u1edd. T\u1ef7 l\u1ec7 h\u1ea5p thu pregabalin gi\u1ea3m khi \u0111\u01b0\u1ee3c d\u00f9ng v\u1edbi th\u1ee9c \u0103n d\u1eabn \u0111\u1ebfn gi\u1ea3m Cmax kho\u1ea3ng 25-30% v\u00e0 l\u00e0m ch\u1eadm Tmax kho\u1ea3ng 2,5 gi\u1edd. Tuy nhi\u00ean, vi\u1ec7c d\u00f9ng pregabalin v\u1edbi th\u1ee9c \u0103n kh\u00f4ng c\u00f3 \u1ea3nh h\u01b0\u1edfng l\u00e2m s\u00e0ng \u0111\u00e1ng k\u1ec3 tr\u00ean m\u1ee9c \u0111\u1ed9 h\u1ea5p thu pregabalin.<\/p>\n<p><em>Ph\u00e2n b\u1ed1:<\/em> Trong c\u00e1c nghi\u00ean c\u1ee9u ti\u1ec1n l\u00e2m s\u00e0ng, pregabalin \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh qua h\u00e0ng r\u00e0o m\u00e1u n\u00e3o \u1edf chu\u1ed9t nh\u1eaft, chu\u1ed9t v\u00e0 kh\u1ec9. Pregabalin \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh qua nhau thai \u1edf chu\u1ed9t v\u00e0 hi\u1ec7n di\u1ec7n trong s\u1eefa \u1edf nh\u1eefng con chu\u1ed9t cho con b\u00fa. \u1ede ng\u01b0\u1eddi, th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 c\u1ee7a pregabalin sau khi u\u1ed1ng l\u00e0 kho\u1ea3ng 0,56 L\/kg. Pregabalin kh\u00f4ng li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<p><em>Chuy\u1ec3n h\u00f3a:<\/em> Pregabalin chuy\u1ec3n h\u00f3a kh\u00f4ng \u0111\u00e1ng k\u1ec3 \u1edf ng\u01b0\u1eddi. Sau m\u1ed9t li\u1ec1u pregabalin \u0111\u00e1nh d\u1ea5u ph\u00f3ng x\u1ea1, kho\u1ea3ng 98% ch\u1ea5t ph\u00f3ng x\u1ea1 thu h\u1ed3i trong n\u01b0\u1edbc ti\u1ec3u l\u00e0 pregabalin d\u1ea1ng kh\u00f4ng \u0111\u1ed5i. C\u00e1c d\u1eabn xu\u1ea5t N-methyl c\u1ee7a pregabalin, c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh c\u1ee7a pregabalin \u0111\u00e3 t\u00ecm th\u1ea5y trong n\u01b0\u1edbc ti\u1ec3u, chi\u1ebfm 0,9% li\u1ec1u d\u00f9ng. Trong c\u00e1c nghi\u00ean c\u1ee9u ti\u1ec1n l\u00e2m s\u00e0ng, kh\u00f4ng c\u00f3 s\u1ef1 racemic h\u00f3a c\u1ee7a pregabalin S-enantiomer th\u00e0nh R-enantiomer.<\/p>\n<p><em>Th\u1ea3i tr\u1eeb:<\/em> Pregabalin \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb kh\u1ecfi h\u1ec7 tu\u1ea7n ho\u00e0n ch\u1ee7 y\u1ebfu do b\u00e0i ti\u1ebft qua th\u1eadn \u1edf d\u1ea1ng c\u00f2n ho\u1ea1t t\u00ednh.<\/p>\n<p>Pregabalin c\u00f3 th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh l\u00e0 6,3 gi\u1edd. \u0110\u1ed9 thanh th\u1ea3i pregabalin huy\u1ebft t\u01b0\u01a1ng v\u00e0 \u0111\u1ed9 thanh th\u1ea3i th\u1eadn l\u00e0 t\u1ef7 l\u1ec7 thu\u1eadn v\u1edbi \u0111\u1ed9 thanh th\u1ea3i creatinin.<\/p>\n<p>C\u1ea7n ch\u1ec9nh li\u1ec1u \u1edf b\u1ec7nh nh\u00e2n gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn ho\u1eb7c ch\u1ea1y th\u1eadn nh\u00e2n t\u1ea1o.<\/p>\n<p><em>Tuy\u1ebfn t\u00ednh\/phi tuy\u1ebfn t\u00ednh:<\/em><\/p>\n<p>D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a pregabalin l\u00e0 tuy\u1ebfn t\u00ednh trong ph\u1ea1m vi li\u1ec1u khuy\u1ebfn c\u00e1o h\u00e0ng ng\u00e0y. Thay \u0111\u1ed5i d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc gi\u1eefa c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng v\u1edbi pregabalin th\u1ea5p (&lt; 20%). D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc \u0111a li\u1ec1u c\u00f3 th\u1ec3 d\u1ef1 \u0111o\u00e1n \u0111\u01b0\u1ee3c t\u1eeb d\u1eef li\u1ec7u li\u1ec1u \u0111\u01a1n. Do \u0111\u00f3, kh\u00f4ng c\u1ea7n theo d\u00f5i th\u01b0\u1eddng xuy\u00ean n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng c\u1ee7a pregabalin.<\/p>\n<p><em>D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc \u1edf c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng \u0111\u1eb7c bi\u1ec7t:<\/em><\/p>\n<p><em>Gi\u1edbi t\u00ednh:<\/em> C\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng cho th\u1ea5y gi\u1edbi t\u00ednh kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng tr\u00ean n\u1ed3ng \u0111\u1ed9 c\u1ee7a pregabalin trong huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<p><em>Suy th\u1eadn:<\/em> \u0110\u1ed9 thanh th\u1ea3i c\u1ee7a pregabalin t\u1ef7 l\u1ec7 thu\u1eadn v\u1edbi \u0111\u1ed9 thanh th\u1ea3i creatinin. Ngo\u00e0i ra, pregabalin \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb m\u1ed9t c\u00e1ch hi\u1ec7u qu\u1ea3 t\u1eeb huy\u1ebft t\u01b0\u01a1ng b\u1eb1ng c\u00e1ch l\u1ecdc m\u00e1u (sau 4 gi\u1edd l\u1ecdc m\u00e1u, n\u1ed3ng \u0111\u1ed9 pregabalin huy\u1ebft t\u01b0\u01a1ng gi\u1ea3m kho\u1ea3ng 50%). B\u1edfi th\u1eadn l\u00e0 \u0111\u01b0\u1eddng th\u1ea3i tr\u1eeb ch\u00ednh, c\u1ea7n gi\u1ea3m li\u1ec1u \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn v\u00e0 d\u00f9ng li\u1ec1u b\u1ed5 sung sau l\u1ecdc m\u00e1u.<\/p>\n<p><em>Suy gan:<\/em> Kh\u00f4ng c\u00f3 nghi\u00ean c\u1ee9u d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc ri\u00eang bi\u1ec7t \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n suy gan. Do pregabalin kh\u00f4ng b\u1ecb chuy\u1ec3n h\u00f3a \u0111\u00e1ng k\u1ec3 v\u00e0 \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft ch\u1ee7 y\u1ebfu trong n\u01b0\u1edbc ti\u1ec3u \u1edf d\u1ea1ng kh\u00f4ng \u0111\u1ed5i, suy ch\u1ee9c n\u0103ng gan d\u1ef1 ki\u1ebfn s\u1ebd kh\u00f4ng thay \u0111\u1ed5i \u0111\u00e1ng k\u1ec3 n\u1ed3ng \u0111\u1ed9 pregabalin trong huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<p><em>Tr\u1ebb em:<\/em> D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a pregabalin \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n nhi b\u1ecb b\u1ec7nh \u0111\u1ed9ng kinh (nh\u00f3m tu\u1ed5i: 1 \u0111\u1ebfn 23 th\u00e1ng, 2 \u0111\u1ebfn 6 tu\u1ed5i, 7 \u0111\u1ebfn 11 tu\u1ed5i v\u00e0 12 \u0111\u1ebfn 16 tu\u1ed5i) \u1edf m\u1ee9c li\u1ec1u 2,5, 5, 10 v\u00e0 15 mg\/kg\/ng\u00e0y \u1edf m\u1ed9t nghi\u00ean c\u1ee9u d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc v\u00e0 kh\u1ea3 n\u0103ng dung n\u1ea1p.<\/p>\n<p>Sau khi u\u1ed1ng pregabalin khi \u0111\u00f3i, nh\u00ecn chung, th\u1eddi gian \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi to\u00e0n b\u1ed9 nh\u00f3m tu\u1ed5i v\u00e0 x\u1ea3y ra \u1edf th\u1eddi \u0111i\u1ec3m 0,5 gi\u1edd \u0111\u1ebfn 2 gi\u1edd sau khi d\u00f9ng thu\u1ed1c.<\/p>\n<p>C\u00e1c th\u00f4ng s\u1ed1 Cmax v\u00e0 AUC t\u0103ng tuy\u1ebfn t\u00ednh v\u1edbi t\u0103ng li\u1ec1u trong m\u1ed7i nh\u00f3m tu\u1ed5i. AUC th\u1ea5p h\u01a1n 30% \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n nhi d\u01b0\u1edbi 30 kg v\u00ec \u0111\u1ed9 thanh th\u1ea3i \u0111i\u1ec1u ch\u1ec9nh theo c\u00e2n n\u1eb7ng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y t\u0103ng 43% so v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n nhi l\u1edbn h\u01a1n 30 kg.<\/p>\n<p>Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a pregabalin kho\u1ea3ng 3 \u0111\u1ebfn 4 gi\u1edd \u1edf b\u1ec7nh nh\u00e2n nhi l\u00ean \u0111\u1ebfn 6 tu\u1ed5i v\u00e0 t\u1eeb 4 \u0111\u1ebfn 6 gi\u1edd \u1edf nh\u1eefng ng\u01b0\u1eddi t\u1eeb 7 tu\u1ed5i tr\u1edf l\u00ean.<\/p>\n<p>Ph\u00e2n t\u00edch d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc trong qu\u1ea7n th\u1ec3 cho th\u1ea5y \u0111\u1ed9 thanh th\u1ea3i creatinin l\u00e0 m\u1ed9t bi\u1ebfn s\u1ed1 \u0111\u00e1ng k\u1ec3 v\u1edbi \u0111\u1ed9 thanh th\u1ea3i c\u1ee7a pregabalin, trong l\u01b0\u1ee3ng c\u01a1 th\u1ec3 \u1ea3nh h\u01b0\u1edfng t\u1edbi th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 c\u1ee7a pregabalin, m\u1ed1i li\u00ean quan n\u00e0y t\u01b0\u01a1ng t\u1ef1 \u1edf ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em.D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc \u1edf tr\u1ebb em d\u01b0\u1edbi 3 th\u00e1ng tu\u1ed5i ch\u01b0a \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u.<\/p>\n<p><em>Ng\u01b0\u1eddi l\u1edbn tu\u1ed5i:<\/em> \u0110\u1ed9 thanh th\u1ea3i pregabalin c\u00f3 xu h\u01b0\u1edbng gi\u1ea3m \u1edf b\u1ec7nh nh\u00e2n l\u1edbn tu\u1ed5i. Vi\u1ec7c gi\u1ea3m n\u00e0y l\u00e0 ph\u00f9 h\u1ee3p v\u1edbi gi\u1ea3m \u0111\u1ed9 thanh th\u1ea3i creatinin \u1edf b\u1ec7nh nh\u00e2n l\u1edbn tu\u1ed5i. N\u00ean gi\u1ea3m li\u1ec1u pregabalin \u1edf b\u1ec7nh nh\u00e2n l\u1edbn tu\u1ed5i b\u1ecb t\u1ed5n th\u01b0\u01a1ng ch\u1ee9c n\u0103ng th\u1eadn.<\/p>\n<p><em>Ph\u1ee5 n\u1eef cho con b\u00fa:<\/em> D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc v\u1edbi li\u1ec1u 150 mg pregabalin m\u1ed7i 12 gi\u1edd (300 mg\/ng\u00e0y) \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 \u1edf 10 ph\u1ee5 n\u1eef cho con b\u00fa \u00edt nh\u1ea5t 12 tu\u1ea7n sau sinh. Vi\u1ec7c cho con b\u00fa \u00edt ho\u1eb7c kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a pregabalin. Pregabalin \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9 v\u1edbi n\u1ed3ng \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh trung b\u00ecnh kho\u1ea3ng 76% n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng c\u1ee7a m\u1eb9. Li\u1ec1u tr\u1ebb s\u01a1 sinh \u01b0\u1edbc t\u00ednh t\u1eeb s\u1eefa m\u1eb9 (gi\u1ea3 s\u1eed m\u1ee9c ti\u00eau th\u1ee5 s\u1eefa trung b\u00ecnh 150 mL\/kg\/ng\u00e0y) c\u1ee7a ph\u1ee5 n\u1eef s\u1eed d\u1ee5ng m\u1ee9c li\u1ec1u 300 mg\/ng\u00e0y ho\u1eb7c li\u1ec1u t\u1ed1i \u0111a 600 mg\/ng\u00e0y s\u1ebd l\u00e0 0,31 ho\u1eb7c 0,62 mg\/kg\/ng\u00e0y. Nh\u1eefng li\u1ec1u \u01b0\u1edbc t\u00ednh n\u00e0y l\u00e0 kho\u1ea3ng 7% t\u1ed5ng li\u1ec1u m\u1eb9 s\u1eed d\u1ee5ng h\u00e0ng ng\u00e0y tr\u00ean v\u1edbi li\u1ec1u mg\/kg.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"53-giai-thich\"><\/span>5.3 Gi\u1ea3i th\u00edch:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"54-thay-the-thuoc\"><\/span>5.4 Thay th\u1ebf thu\u1ed1c :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h1><span class=\"ez-toc-section\" id=\"6-phan-thong-tin-kem-theo-cua-thuoc\"><\/span>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"61-danh-muc-ta-duoc\"><\/span>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>&#8230;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"62-tuong-ky\"><\/span>6.2. T\u01b0\u01a1ng k\u1ef5 :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Kh\u00f4ng \u00e1p d\u1ee5ng.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"63-bao-quan\"><\/span>6.3. B\u1ea3o qu\u1ea3n:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>N\u01a1i kh\u00f4, tr\u00e1nh \u00e1nh s\u00e1ng, nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30\u00b0C.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"64-thong-tin-khac\"><\/span>6.4. Th\u00f4ng tin kh\u00e1c :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Kh\u00f4ng c\u00f3.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"65-tai-lieu-tham-khao\"><\/span>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n<p>HDSD Thu\u1ed1c Brieka 75mg do Balkanpharma &#8211; Dupnitsa AD s\u1ea3n xu\u1ea5t (2019).<\/p>\n<h1><span class=\"ez-toc-section\" id=\"7-nguoi-dang-tai-tac-gia\"><\/span>7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p>B\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c s\u01b0u t\u1ea7m ho\u1eb7c vi\u1ebft b\u1edfi: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-tac-gia-bac-sy-do-my-linh\/\">B\u00e1c s\u0129 nhi khoa &#8211; \u0110\u1ed7 M\u1ef9 Linh.<\/a><\/p>\n<p>Ki\u1ec3m duy\u1ec7t , hi\u1ec7u \u0111\u00ednh v\u00e0 \u0111\u0103ng t\u1ea3i: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-ve-pharmog-team\/\">PHARMOG TEAM<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Brieka l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Brieka (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;) 1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Pregabalin (Pregabaline) Ph\u00e2n lo\u1ea1i: Thu\u1ed1c ch\u1ed1ng co gi\u1eadt, [&hellip;]<\/p>\n","protected":false},"author":8612,"featured_media":42113,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[1669],"class_list":["post-42100","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-pregabalin"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/42100","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/8612"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=42100"}],"version-history":[{"count":1,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/42100\/revisions"}],"predecessor-version":[{"id":42152,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/42100\/revisions\/42152"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/42113"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=42100"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=42100"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=42100"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}