{"id":4051,"date":"2019-02-12T16:07:11","date_gmt":"2019-02-12T09:07:11","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=4051"},"modified":"2025-01-08T22:27:41","modified_gmt":"2025-01-08T15:27:41","slug":"spectinomycine","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/spectinomycine\/","title":{"rendered":"Spectinomycine"},"content":{"rendered":"<p><em>Thu\u1ed1c Spectinomycin l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Spectinomycin (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;)<\/em><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_81 ez-toc-wrap-left counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">N\u1ed9i dung ch\u00ednh<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#1-ten-hoat-chat-va-biet-duoc\" >1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#2-dang-bao-che-%e2%80%93-ham-luong\" >2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#3-video-by-pharmog\" >3. Video by Pharmog:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#4-ung-dung-lam-sang\" >4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng:<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#41-chi-dinh\" >4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#42-lieu-dung-%e2%80%93-cach-dung\" >4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#43-chong-chi-dinh\" >4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#44-than-trong\" >4.4 Th\u1eadn tr\u1ecdng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#45-su-dung-cho-phu-nu-co-thai-va-cho-con-bu\" >4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#46-tac-dung-khong-mong-muon-adr\" >4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#47-huong-dan-cach-xu-tri-adr\" >4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#48-tuong-tac-voi-cac-thuoc-khac\" >4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#49-qua-lieu-va-xu-tri\" >4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#5-co-che-tac-dung-cua-thuoc\" >5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#51-duoc-luc-hoc\" >5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#52-duoc-dong-hoc\" >5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#53-giai-thich\" >5.3 Gi\u1ea3i th\u00edch:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#54-thay-the-thuoc\" >5.4 Thay th\u1ebf thu\u1ed1c :<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#6-phan-thong-tin-kem-theo-cua-thuoc\" >6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#61-danh-muc-ta-duoc\" >6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#62-tuong-ky\" >6.2. T\u01b0\u01a1ng k\u1ef5 :<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#63-bao-quan\" >6.3. B\u1ea3o qu\u1ea3n:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#64-thong-tin-khac\" >6.4. Th\u00f4ng tin kh\u00e1c :<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#65-tai-lieu-tham-khao\" >6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/#7-nguoi-dang-tai-tac-gia\" >7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<\/a><\/li><\/ul><\/nav><\/div>\n\n<h1><span class=\"ez-toc-section\" id=\"1-ten-hoat-chat-va-biet-duoc\"><\/span>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <\/strong><a href=\"https:\/\/pharmog.com\/wp\/spectinomycine\/\"><strong>Spectinomycin<\/strong><\/a><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u1ed1c kh\u00e1ng sinh (aminocyclitol) nh\u00f3m Aminoglycoside<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): J01XX04.<\/p>\n<p><strong>Brand name:<\/strong><\/p>\n<p><strong>Generic <\/strong>: Spectinomycin, Kuktrim; Sipimycin; Speclif; <a href=\"https:\/\/pharmog.com\/wp\/spectinomycin-spectimed\/\">Spectimed<\/a>; <a href=\"https:\/\/pharmog.com\/wp\/spectinomycin-spectinomycin-hydrochloride-for-injection\/\">Spectinomycin Hydrochloride for Injection<\/a><\/p>\n<h1><span class=\"ez-toc-section\" id=\"2-dang-bao-che-%e2%80%93-ham-luong\"><\/span>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>L\u1ecd b\u1ed9t pha ti\u00eam ch\u1ee9a spectinomycin hydroclorid t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 2 g spectinomycin v\u00e0 \u1ed1ng n\u01b0\u1edbc c\u1ea5t pha ti\u00eam \u0111\u1ec3 h\u00f2a tan.<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>SPECTIMED<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i l\u1ecd b\u1ed9t pha ti\u00eam c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Spectinomycin<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>2000 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"332\" height=\"390\" class=\"wp-image-34899\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/02\/word-image-46.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/02\/word-image-46.png 332w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/02\/word-image-46-255x300.png 255w\" sizes=\"auto, (max-width: 332px) 100vw, 332px\" \/><\/p>\n<h1><span class=\"ez-toc-section\" id=\"3-video-by-pharmog\"><\/span>3. Video by Pharmog:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe loading=\"lazy\" title=\"[Pharmog SS1 - T\u1eadp 08] - D\u01b0\u1ee3c l\u00fd c\u00e1c thu\u1ed1c kh\u00e1ng sinh\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/0TIIfoiJFwA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<h1><span class=\"ez-toc-section\" id=\"4-ung-dung-lam-sang\"><\/span>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"41-chi-dinh\"><\/span>4.1. Ch\u1ec9 \u0111\u1ecbnh:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>D\u00f9ng m\u1ed9t li\u1ec1u duy nh\u1ea5t (ti\u00eam b\u1eafp 2 g) \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh l\u1eadu c\u1ea5p kh\u00f4ng bi\u1ebfn ch\u1ee9ng (\u1edf \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u, c\u1ed5 t\u1eed cung, h\u1ea7u h\u1ecdng ho\u1eb7c tr\u1ef1c tr\u00e0ng) do <em>Neisseria gonorrhoeae<\/em> nh\u1ea1y c\u1ea3m \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n m\u1eabn c\u1ea3m ho\u1eb7c kh\u00f4ng dung n\u1ea1p kh\u00e1ng sinh nh\u00f3m cephalosporin ho\u1eb7c fluoroquinolon.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb nhi\u1ec5m tr\u00f9ng l\u1eadu c\u1ea7u lan t\u1ecfa.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb b\u1ec7nh h\u1ea1 cam do <em>Haemophilus ducreyi.<\/em><\/p>\n<h2><span class=\"ez-toc-section\" id=\"42-lieu-dung-%e2%80%93-cach-dung\"><\/span>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p><em>H\u01b0\u1edbng d\u1eabn pha thu\u1ed1c:<\/em> Khi pha thu\u1ed1c \u0111\u1ec3 ti\u00eam, d\u00f9ng 3,2 ml n\u01b0\u1edbc c\u1ea5t v\u00f4 khu\u1ea9n cho v\u00e0o l\u1ecd 2 g spectinomycin, ho\u1eb7c 6,2 ml cho v\u00e0o l\u1ecd 4 g \u0111\u1ec3 c\u00f3 n\u1ed3ng \u0111\u1ed9 400 mg\/ml. L\u1eafc m\u1ea1nh sau khi cho dung m\u00f4i v\u00e0 tr\u01b0\u1edbc khi h\u00fat m\u1ed7i li\u1ec1u.<\/p>\n<p>Spectinomycin \u0111\u01b0\u1ee3c d\u00f9ng theo \u0111\u01b0\u1eddng ti\u00eam b\u1eafp s\u00e2u, li\u1ec1u d\u00f9ng \u0111\u01b0\u1ee3c t\u00ednh theo d\u1ea1ng base.<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p><em>Ng\u01b0\u1eddi l\u1edbn:<\/em><\/p>\n<p>\u0110i\u1ec1u tr\u1ecb b\u1ec7nh l\u1eadu (\u1edf \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u, c\u1ed5 t\u1eed cung, h\u1ea7u h\u1ecdng ho\u1eb7c tr\u1ef1c tr\u00e0ng) kh\u00f4ng bi\u1ebfn ch\u1ee9ng cho b\u1ec7nh nh\u00e2n nhi\u1ec5m l\u1eadu c\u1ea7u kh\u00e1ng penicilin v\u00e0 b\u1ec7nh nh\u00e2n d\u1ecb \u1ee9ng v\u1edbi penicilin G: Ti\u00eam 1 li\u1ec1u duy nh\u1ea5t 2 g. C\u00f3 th\u1ec3 d\u00f9ng t\u1edbi 4 g \u1edf nh\u1eefng tr\u01b0\u1eddng h\u1ee3p kh\u00f3 \u0111i\u1ec1u tr\u1ecb v\u00e0 b\u1ec7nh nh\u00e2n \u1edf nh\u1eefng v\u00f9ng c\u00f3 t\u1ef7 l\u1ec7 vi khu\u1ea9n kh\u00e1ng kh\u00e1ng sinh cao. Ti\u00eam b\u1eafp s\u00e2u v\u00e0o v\u00f9ng 1\/4 tr\u00ean ngo\u00e0i m\u00f4ng. C\u00f3 th\u1ec3 chia \u0111\u00f4i li\u1ec1u 4 g \u0111\u1ec3 ti\u00eam v\u00e0o hai v\u1ecb tr\u00ed kh\u00e1c nhau.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb nhi\u1ec5m tr\u00f9ng l\u1eadu c\u1ea7u lan t\u1ecfa: Ti\u00eam b\u1eafp 2 g c\u00e1ch 12 gi\u1edd\/l\u1ea7n.<\/p>\n<p>Li\u1ec1u d\u00f9ng n\u00e0y n\u00ean \u0111\u01b0\u1ee3c duy tr\u00ec trong v\u00f2ng 24 &#8211; 48 gi\u1edd sau khi b\u1eaft \u0111\u1ea7u c\u00f3 c\u1ea3i thi\u1ec7n l\u00e2m s\u00e0ng, sau \u0111\u00f3, chuy\u1ec3n sang u\u1ed1ng cefpodoxim ho\u1eb7c cefixim \u00edt nh\u1ea5t 1 tu\u1ea7n.<\/p>\n<p><em>Ng\u01b0\u1eddi cao tu\u1ed5i:<\/em> D\u00f9ng li\u1ec1u c\u1ee7a ng\u01b0\u1eddi l\u1edbn b\u00ecnh th\u01b0\u1eddng.<\/p>\n<p><em>Tr\u1ebb em:<\/em><\/p>\n<p>Tr\u1ebb &lt; 45 kg: 40 mg\/kg c\u00e2n n\u1eb7ng (t\u1ed1i \u0111a 2 g) 1 li\u1ec1u duy nh\u1ea5t.<\/p>\n<p>Tr\u1ebb &gt; 45 kg: Nh\u01b0 li\u1ec1u cho ng\u01b0\u1eddi l\u1edbn.<\/p>\n<p>Spectinomycin kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng cho tr\u1ebb s\u01a1 sinh do s\u1ef1 c\u00f3 m\u1eb7t c\u1ee7a alcol benzylic trong th\u00e0nh ph\u1ea7n c\u1ee7a thu\u1ed1c. Ch\u1ea5t b\u1ea3o qu\u1ea3n n\u00e0y c\u00f3 li\u00ean quan \u0111\u1ebfn m\u1ed9t s\u1ed1 ca t\u1eed vong \u1edf tr\u1ebb s\u01a1 sinh do h\u1ed9i ch\u1ee9ng th\u1edf g\u1ea5p. Tuy nhi\u00ean, trong tr\u01b0\u1eddng h\u1ee3p d\u1ef1 ph\u00f2ng cho tr\u1ebb s\u01a1 sinh c\u00f3 m\u1eb9 m\u1eafc b\u1ec7nh l\u1eadu, T\u1ed5 ch\u1ee9c Y t\u1ebf Th\u1ebf gi\u1edbi (WHO) cho ph\u00e9p ti\u00eam spectinomycin 25 mg\/kg c\u00e2n n\u1eb7ng (t\u1ed1i \u0111a 75 mg) 1 li\u1ec1u duy nh\u1ea5t khi kh\u00f4ng th\u1ec3 s\u1eed d\u1ee5ng ceftriaxon.<\/p>\n<p><em>B\u1ec7nh nh\u00e2n suy th\u1eadn:<\/em> Kh\u00f4ng c\u1ea7n hi\u1ec7u ch\u1ec9nh li\u1ec1u.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"43-chong-chi-dinh\"><\/span>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Qu\u00e1 m\u1eabn v\u1edbi spectinomycin ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"44-than-trong\"><\/span>4.4 Th\u1eadn tr\u1ecdng:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Spectinomycin kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng \u0111\u1ed1i v\u1edbi giang mai \u0111ang \u1ee7 b\u1ec7nh hay \u0111\u00e3 ph\u00e1t b\u1ec7nh. Tuy nhi\u00ean, khi d\u00f9ng li\u1ec1u cao trong th\u1eddi gian ng\u1eafn \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb l\u1eadu, spectinomycin l\u00e0m che l\u1ea5p ho\u1eb7c l\u00e0m ch\u1eadm xu\u1ea5t hi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh giang mai. Do \u0111\u00f3, nh\u1eefng b\u1ec7nh nh\u00e2n \u0111ang \u0111i\u1ec1u tr\u1ecb l\u1eadu c\u1ea7n \u0111\u01b0\u1ee3c theo d\u00f5i l\u00e2m s\u00e0ng ch\u1eb7t ch\u1ebd t\u1eeb 4 &#8211; 6 tu\u1ea7n v\u00e0 n\u1ebfu c\u00f3 nghi ng\u1edd giang mai th\u00ec ph\u1ea3i theo d\u00f5i huy\u1ebft thanh \u0111\u1ea7y \u0111\u1ee7 \u00edt nh\u1ea5t trong 4 th\u00e1ng. Khi \u0111\u01b0\u1ee3c ch\u1ea5n \u0111o\u00e1n l\u1eadu, b\u1ec7nh nh\u00e2n n\u00ean \u0111\u01b0\u1ee3c ki\u1ec3m tra c\u1ea3 nhi\u1ec5m giang mai b\u1eb1ng ch\u1ea5n \u0111o\u00e1n huy\u1ebft thanh v\u00e0 ki\u1ec3m tra l\u1ea1i sau \u0111\u00f3 3 th\u00e1ng.<\/p>\n<p>Vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c k\u00e9o d\u00e0i c\u00f3 th\u1ec3 g\u00e2y b\u1ed9i nhi\u1ec5m n\u1ea5m v\u00e0 vi khu\u1ea9n, bao g\u1ed3m c\u1ea3 ti\u00eau ch\u1ea3y v\u00e0 vi\u00eam ru\u1ed9t k\u1ebft gi\u1ea3 m\u1ea1c li\u00ean quan \u0111\u1ebfn vi khu\u1ea9n <em>Clostridium difficile.<\/em> Ti\u00eau ch\u1ea3y li\u00ean quan \u0111\u1ebfn <em>Clostridium difficile<\/em> \u0111\u01b0\u1ee3c ghi nh\u1eadn xu\u1ea5t hi\u1ec7n mu\u1ed9n, 2 th\u00e1ng sau khi \u0111i\u1ec1u tr\u1ecb kh\u00e1ng sinh.<\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>C\u1ea7n th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng cho c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"45-su-dung-cho-phu-nu-co-thai-va-cho-con-bu\"><\/span>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: B1<\/p>\n<p>US FDA pregnancy category: NA<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>D\u1eef li\u1ec7u th\u1ef1c nghi\u1ec7m tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y spectinomycin kh\u00f4ng g\u00e2y ADR tr\u00ean thai ho\u1eb7c kh\u1ea3 n\u0103ng sinh s\u1ea3n. Tuy nhi\u00ean, hi\u1ec7n ch\u01b0a c\u00f3 d\u1eef li\u1ec7u v\u1ec1 \u0111\u1ed9 an to\u00e0n tr\u00ean ph\u1ee5 n\u1eef mang thai. V\u00ec v\u1eady, ch\u1ec9 s\u1eed d\u1ee5ng spectinomycin cho ph\u1ee5 n\u1eef mang thai trong tr\u01b0\u1eddng h\u1ee3p th\u1eadt s\u1ef1 c\u1ea7n thi\u1ebft (d\u1ecb \u1ee9ng v\u1edbi kh\u00e1ng sinh nh\u00f3m cephalosporin).<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>Nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y ch\u1ec9 m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf spectinomycin th\u1ea3i tr\u1eeb v\u00e0o s\u1eefa, tuy nhi\u00ean, ch\u01b0a ghi nh\u1eadn \u0111\u01b0\u1ee3c nguy c\u01a1 tr\u00ean ng\u01b0\u1eddi. D\u1eef li\u1ec7u n\u00e0y ch\u01b0a \u0111\u1ee7 \u0111\u1ec3 khuy\u1ebfn c\u00e1o vi\u1ec7c d\u00f9ng spectinomycin cho ph\u1ee5 n\u1eef \u0111ang cho con b\u00fa. V\u00ec v\u1eady, c\u1ea7n th\u1eadn tr\u1ecdng c\u00e2n nh\u1eafc nguy c\u01a1\/ l\u1ee3i \u00edch khi s\u1eed d\u1ee5ng spectinomycin cho ph\u1ee5 n\u1eef cho con b\u00fa.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"46-tac-dung-khong-mong-muon-adr\"><\/span>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>Th\u01b0\u1eddng g\u1eb7p, ADR &gt;1\/100 <\/em><\/p>\n<p>To\u00e0n th\u00e2n: \u0110au t\u1ea1i ch\u1ed7 ti\u00eam.<\/p>\n<p><em>\u00cdt g\u1eb7p, 1\/1 000 &lt; ADR &lt; 1\/100<\/em><\/p>\n<p>To\u00e0n th\u00e2n: S\u1ed1t, r\u00e9t run, \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t.<\/p>\n<p>Ti\u00eau h\u00f3a: Bu\u1ed3n n\u00f4n, n\u00f4n, co th\u1eaft b\u1ee5ng.<\/p>\n<p>Da: Ng\u1ee9a, m\u00e0y \u0111ay.<\/p>\n<p>(Khi d\u00f9ng li\u1ec1u l\u1eb7p l\u1ea1i c\u00f3 th\u1ec3 gi\u1ea3m hemoglobin, hematocrit, gi\u1ea3m Cl v\u00e0 t\u0103ng phosphatase ki\u1ec1m, SGPT v\u00e0 ur\u00ea huy\u1ebft. C\u00e1c ADR n\u00e0y kh\u00f4ng \u0111\u01b0\u1ee3c ghi nh\u1eadn khi d\u00f9ng li\u1ec1u duy nh\u1ea5t).<\/p>\n<p><em>Hi\u1ebfm g\u1eb7p, ADR &lt;1\/1 000<\/em><\/p>\n<p>S\u1ed1c ph\u1ea3n v\u1ec7, \u0111\u1ed9c v\u1edbi th\u1eadn v\u00e0 thi\u1ebfu m\u00e1u.<\/p>\n<p>Spectinomycin kh\u00f4ng d\u1ecb \u1ee9ng ch\u00e9o v\u1edbi c\u00e1c kh\u00e1ng sinh penicilin.<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<h2><span class=\"ez-toc-section\" id=\"47-huong-dan-cach-xu-tri-adr\"><\/span>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c. V\u1edbi c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i nh\u1eb9, th\u01b0\u1eddng ch\u1ec9 c\u1ea7n ng\u1eebng thu\u1ed1c. Tr\u01b0\u1eddng h\u1ee3p m\u1eabn c\u1ea3m n\u1eb7ng ho\u1eb7c ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, c\u1ea7n ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 (gi\u1eef tho\u00e1ng kh\u00ed v\u00e0 d\u00f9ng epinephrin, th\u1edf oxygen, d\u00f9ng kh\u00e1ng histamin, corticoid&#8230;).<\/p>\n<h2><span class=\"ez-toc-section\" id=\"48-tuong-tac-voi-cac-thuoc-khac\"><\/span>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Spectinomycin l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng v\u00e0 \u0111\u1ed9c t\u00ednh c\u1ee7a lithi do gi\u1ea3m \u0111\u1ed9 thanh th\u1ea3i lithi. Th\u1eadn tr\u1ecdng theo d\u00f5i \u0111\u00e1p \u1ee9ng l\u00e2m s\u00e0ng v\u00e0 n\u1ed3ng \u0111\u1ed9 c\u1ee7a lithi trong huy\u1ebft thanh n\u1ebfu d\u00f9ng \u0111\u1ed3ng th\u1eddi hai thu\u1ed1c n\u00e0y.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"49-qua-lieu-va-xu-tri\"><\/span>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Ch\u01b0a c\u00f3 b\u00e1o c\u00e1o v\u1ec1 qu\u00e1 li\u1ec1u.<\/p>\n<p>V\u00ec kh\u00f4ng c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u, \u0111i\u1ec1u tr\u1ecb qu\u00e1 li\u1ec1u ho\u1eb7c c\u00e1c ph\u1ea3n \u1ee9ng \u0111\u1ed9c c\u1ee7a aminoglycosid l\u00e0 ch\u1eefa tri\u1ec7u ch\u1ee9ng v\u00e0 h\u1ed7 tr\u1ee3.<\/p>\n<p><em>C\u00e1ch \u0111i\u1ec1u tr\u1ecb \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o nh\u01b0 sau:<\/em><\/p>\n<p>Th\u1ea9m t\u00e1ch m\u00e1u ho\u1eb7c th\u1ea9m t\u00e1ch ph\u00fac m\u1ea1c \u0111\u1ec3 lo\u1ea1i aminoglycosid ra kh\u1ecfi m\u00e1u c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh suy th\u1eadn.<\/p>\n<p>D\u00f9ng c\u00e1c thu\u1ed1c kh\u00e1ng cholinesterase, c\u00e1c mu\u1ed1i calci, ho\u1eb7c h\u00f4 h\u1ea5p nh\u00e2n t\u1ea1o \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ch\u1eb9n th\u1ea7n kinh c\u01a1 d\u1eabn \u0111\u1ebfn y\u1ebfu c\u01a1 k\u00e9o d\u00e0i v\u00e0 suy h\u00f4 h\u1ea5p ho\u1eb7c li\u1ec7t (ng\u1eebng th\u1edf) c\u00f3 th\u1ec3 x\u1ea3y ra khi d\u00f9ng hai ho\u1eb7c nhi\u1ec1u aminoglycosid \u0111\u1ed3ng th\u1eddi.<\/p>\n<h1><span class=\"ez-toc-section\" id=\"5-co-che-tac-dung-cua-thuoc\"><\/span>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"51-duoc-luc-hoc\"><\/span>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Spectinomycin l\u00e0 m\u1ed9t kh\u00e1ng sinh aminocyclitol thu \u0111\u01b0\u1ee3c t\u1eeb m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y <em>Streptomyces spectabilis.<\/em><\/p>\n<p><em>Ph\u1ed5 t\u00e1c d\u1ee5ng:<\/em><\/p>\n<p>Spectinomycin c\u00f3 t\u00e1c d\u1ee5ng trung b\u00ecnh, \u0111\u1eb7c bi\u1ec7t, tr\u00ean c\u00e1c vi khu\u1ea9n Gram d\u01b0\u01a1ng. Thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng tr\u00ean nhi\u1ec1u vi khu\u1ea9n Gram \u00e2m g\u1ed3m c\u00e1c tr\u1ef1c khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t <em>(E. coli, Klebsiella pneumoniae, Enterobacter, Shigella, Salmonella)<\/em> v\u00e0 <em>Haemophilus ducreyi<\/em> nh\u01b0ng kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng \u0111\u1ed1i v\u1edbi <em>Providencia <\/em>spp. v\u00e0 <em>Pseudomonas aeruginosa.<\/em> Spectinomycin \u0111\u1eb7c bi\u1ec7t c\u00f3 hi\u1ec7u qu\u1ea3 \u0111\u1ed1i v\u1edbi <em>Neisseria gonorrhoeae. <\/em><\/p>\n<p><em>In vitro,<\/em> \u1edf n\u1ed3ng \u0111\u1ed9 t\u1eeb 1 &#8211; 20 microgam\/ml, spectinomycin \u1ee9c ch\u1ebf ph\u1ea7n l\u1edbn c\u00e1c ch\u1ee7ng <em>Neisseria gonorrhoeae<\/em> ti\u1ebft ho\u1eb7c kh\u00f4ng ti\u1ebft penicilinase. Khi th\u1eed \u0111\u1ed9 nh\u1ea1y c\u1ea3m c\u1ee7a <em>N. gonorrhoeae<\/em> v\u1edbi spectinomycin, ch\u1ee7ng c\u00f3 n\u1ed3ng \u0111\u1ed9 t\u1ed1i thi\u1ec3u \u1ee9c ch\u1ebf (MIC) &lt; 32 microgam\/ml \u0111\u01b0\u1ee3c coi l\u00e0 nh\u1ea1y c\u1ea3m; ch\u1ee7ng c\u00f3 MIC t\u1eeb 32 &#8211; 64 microgam\/ml \u0111\u01b0\u1ee3c coi l\u00e0 nh\u1ea1y c\u1ea3m trung gian v\u00e0 &gt; 128 microgam\/ml tr\u1edf l\u00ean \u0111\u01b0\u1ee3c coi l\u00e0 ch\u1ee7ng kh\u00e1ng thu\u1ed1c. Spectinomycin kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng \u0111\u1ed1i v\u1edbi ph\u1ea7n l\u1edbn vi khu\u1ea9n k\u1ef5 kh\u00ed. Tr\u00ean vi khu\u1ea9n n\u1ed9i b\u00e0o, spectinomycin c\u00f3 t\u00e1c d\u1ee5ng tr\u00ean <em>Ureaplasma urealyticum<\/em> nh\u01b0ng kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng v\u1edbi <em>Chlamydia trachomatis. <\/em>Thu\u1ed1c kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng tr\u00ean <em>Treponema pallidum.<\/em><\/p>\n<p><em>Kh\u00e1ng thu\u1ed1c:<\/em> C\u00e1c ch\u1ee7ng <em>Neisseri\u00e0 gonorrhoeae<\/em> ti\u1ebft ho\u1eb7c kh\u00f4ng ti\u1ebft penicilinase kh\u00e1ng spectinomycin \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o. T\u00ecnh tr\u1ea1ng kh\u00e1ng spectinomycin kh\u00f4ng ph\u1ed5 bi\u1ebfn, thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng v\u1edbi \u0111a s\u1ed1 c\u00e1c ch\u1ee7ng <em>Neisseria gonorrhoeae<\/em> kh\u00e1ng fluoroquinolon. C\u01a1 ch\u1ebf ch\u00ednh x\u00e1c kh\u00e1ng spectinomycin ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh r\u00f5. Tuy nhi\u00ean, m\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u cho th\u1ea5y c\u00f3 th\u1ec3 do m\u1ed9t bi\u1ebfn \u0111\u1ed5i trong ribosom.<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>Thu\u1ed1c g\u1eafn v\u1edbi ti\u1ec3u ph\u1ea7n 30S c\u1ee7a ribosom vi khu\u1ea9n \u0111\u1ec3 \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p protein \u1edf vi khu\u1ea9n. Spectinomycin th\u01b0\u1eddng c\u00f3 t\u00e1c d\u1ee5ng k\u00ecm khu\u1ea9n. \u1edf n\u1ed3ng \u0111\u1ed9 cao, thu\u1ed1c kh\u00f4ng di\u1ec7t \u0111\u01b0\u1ee3c <em>E. coli.<\/em> Tuy nhi\u00ean, \u0111\u1ed1i v\u1edbi <em>Neisseria gonorrhoeae,<\/em> spectinomycin c\u00f3 t\u00e1c d\u1ee5ng di\u1ec7t khu\u1ea9n m\u1ea1nh h\u01a1n penicilin, tetracyclin v\u00e0 kanamycin. Spectinomycin c\u0169ng l\u00e0m thay \u0111\u1ed5i h\u00ecnh th\u00e1i b\u1ec1 m\u1eb7t l\u1eadu c\u1ea7u, d\u1eabn \u0111\u1ebfn ly gi\u1ea3i vi khu\u1ea9n do \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p protein m\u00e0ng b\u00e0o t\u01b0\u01a1ng c\u1ee7a vi khu\u1ea9n v\u00e0 thay \u0111\u1ed5i s\u1ef1 to\u00e0n v\u1eb9n c\u1ee7a t\u1ebf b\u00e0o d\u01b0\u1edbi \u1ea3nh h\u01b0\u1edfng c\u1ee7a \u00e1p l\u1ef1c th\u1ea9m th\u1ea5u.<\/p>\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe loading=\"lazy\" title=\"[Pharmog E SS1 - Ep. 01] - Pharmacology of all Antibiotics\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/9bo1ZCykDso?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/p>\n<h2><span class=\"ez-toc-section\" id=\"52-duoc-dong-hoc\"><\/span>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>H\u1ea5p thu<\/em>: Spectinomycin h\u1ea5p thu k\u00e9m qua \u0111\u01b0\u1eddng u\u1ed1ng nh\u01b0ng h\u1ea5p thu r\u1ea5t nhanh v\u00e0 g\u1ea7n ho\u00e0n to\u00e0n sau khi ti\u00eam b\u1eafp. \u1edf ng\u01b0\u1eddi l\u1edbn c\u00f3 ch\u1ee9c n\u0103ng th\u1eadn b\u00ecnh th\u01b0\u1eddng, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh c\u1ee7a thu\u1ed1c trong huy\u1ebft thanh \u0111\u1ea1t \u0111\u01b0\u1ee3c khi ti\u00eam li\u1ec1u 2 g l\u00e0 100 microgam\/ml sau 1 gi\u1edd, khi ti\u00eam li\u1ec1u 4 g l\u00e0 kho\u1ea3ng 160 microgam\/ml sau 2 gi\u1edd. N\u1ed3ng \u0111\u1ed9 \u0111i\u1ec1u tr\u1ecb trong huy\u1ebft t\u01b0\u01a1ng \u0111\u01b0\u1ee3c duy tr\u00ec trong v\u00f2ng 8 gi\u1edd.<\/p>\n<p><em>Ph\u00e2n b\u1ed1:<\/em> Thu\u1ed1c g\u1eafn \u00edt v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng, ch\u1ee7 y\u1ebfu ph\u00e2n b\u1ed1 trong huy\u1ebft t\u01b0\u01a1ng v\u00e0 d\u1ecbch ngo\u1ea1i b\u00e0o. Thu\u1ed1c ph\u00e2n b\u1ed1 k\u00e9m v\u00e0o n\u01b0\u1edbc b\u1ecdt n\u00ean h\u1ea1n ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a spectinomycin khi \u0111i\u1ec1u tr\u1ecb l\u1eadu \u1edf h\u1ecdng. Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 c\u1ee7a spectinomycin kho\u1ea3ng 16,2 &#8211; 19,3 l\u00edt. Kh\u00f4ng r\u00f5 li\u1ec7u thu\u1ed1c c\u00f3 qua \u0111\u01b0\u1ee3c nhau thai ho\u1eb7c v\u00e0o s\u1eefa m\u1eb9 kh\u00f4ng.<\/p>\n<p><em>Th\u1ea3i tr\u1eeb<\/em>: Kho\u1ea3ng 70 &#8211; 80% li\u1ec1u thu\u1ed1c \u0111\u01b0a v\u00e0o \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i v\u00e0o n\u01b0\u1edbc ti\u1ec3u trong v\u00f2ng 48 gi\u1edd d\u01b0\u1edbi d\u1ea1ng nguy\u00ean v\u1eb9n v\u00e0 d\u1ea1ng chuy\u1ec3n h\u00f3a c\u00f2n ho\u1ea1t t\u00ednh sinh h\u1ecdc. N\u1ed3ng \u0111\u1ed9 thu\u1ed1c \u1edf d\u1ea1ng c\u00f3 ho\u1ea1t t\u00ednh trong n\u01b0\u1edbc ti\u1ec3u l\u00e0 1.000 mg\/l\u00edt N\u1eeda \u0111\u1eddi th\u1ea3i tr\u1eeb c\u1ee7a spectinomycin kho\u1ea3ng 1 &#8211; 3 gi\u1edd, k\u00e9o d\u00e0i \u1edf b\u1ec7nh nh\u00e2n c\u00f3 suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn. Spectinomycin \u0111\u01b0\u1ee3c lo\u1ea1i tr\u1eeb m\u1ed9t ph\u1ea7n b\u1eb1ng th\u1ea9m t\u00edch m\u00e1u ho\u1eb7c th\u1ea9m ph\u00e2n ph\u00fac m\u1ea1c.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"53-giai-thich\"><\/span>5.3 Gi\u1ea3i th\u00edch:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"54-thay-the-thuoc\"><\/span>5.4 Thay th\u1ebf thu\u1ed1c :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<h1><span class=\"ez-toc-section\" id=\"6-phan-thong-tin-kem-theo-cua-thuoc\"><\/span>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"61-danh-muc-ta-duoc\"><\/span>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Kh\u00f4ng c\u00f3.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"62-tuong-ky\"><\/span>6.2. T\u01b0\u01a1ng k\u1ef5 :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Kh\u00f4ng \u00e1p d\u1ee5ng.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"63-bao-quan\"><\/span>6.3. B\u1ea3o qu\u1ea3n:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>B\u1ea3o qu\u1ea3n l\u1ecd b\u1ed9t pha ti\u00eam ch\u1ee9a spectinomycin hydroclorid \u1edf nhi\u1ec7t \u0111\u1ed9 15 &#8211; 30 <sup>o<\/sup>C.<\/p>\n<p>H\u1ed7n d\u1ecbch pha ngay tr\u01b0\u1edbc khi d\u00f9ng. Lo\u1ea1i b\u1ecf ph\u1ea7n h\u1ed7n d\u1ecbch kh\u00f4ng d\u00f9ng \u0111\u1ebfn.<\/p>\n<p>H\u1ed7n d\u1ecbch ti\u00eam sau khi pha ch\u01b0a s\u1eed d\u1ee5ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c b\u1ea3o qu\u1ea3n \u1edf 25 <sup>o<\/sup>C trong 24 gi\u1edd.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"64-thong-tin-khac\"><\/span>6.4. Th\u00f4ng tin kh\u00e1c :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Kh\u00f4ng c\u00f3.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"65-tai-lieu-tham-khao\"><\/span>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n<p>Ho\u1eb7c HDSD Thu\u1ed1c.<\/p>\n<h1><span class=\"ez-toc-section\" id=\"7-nguoi-dang-tai-tac-gia\"><\/span>7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p>B\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c s\u01b0u t\u1ea7m ho\u1eb7c vi\u1ebft b\u1edfi: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-tac-gia-bac-sy-do-my-linh\/\">B\u00e1c s\u0129 nhi khoa &#8211; \u0110\u1ed7 M\u1ef9 Linh.<\/a><\/p>\n<p>Ki\u1ec3m duy\u1ec7t , hi\u1ec7u \u0111\u00ednh v\u00e0 \u0111\u0103ng t\u1ea3i: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-ve-pharmog-team\/\">PHARMOG TEAM<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Spectinomycin l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Spectinomycin (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;) 1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Spectinomycin Ph\u00e2n lo\u1ea1i: Thu\u1ed1c kh\u00e1ng sinh (aminocyclitol) nh\u00f3m [&hellip;]<\/p>\n","protected":false},"author":8612,"featured_media":34898,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[2],"tags":[1355],"class_list":["post-4051","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-thuoc-a-z","tag-spectinomycin"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/4051","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/8612"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=4051"}],"version-history":[{"count":5,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/4051\/revisions"}],"predecessor-version":[{"id":34900,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/4051\/revisions\/34900"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/34898"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=4051"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=4051"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=4051"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}