{"id":40113,"date":"2022-01-19T14:51:31","date_gmt":"2022-01-19T07:51:31","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=40113"},"modified":"2025-01-07T22:31:19","modified_gmt":"2025-01-07T15:31:19","slug":"losartan-losartan-domesco","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/","title":{"rendered":"Losartan &#8211; Losartan Domesco"},"content":{"rendered":"<p><em>Thu\u1ed1c Losartan Domesco l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Losartan Domesco (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;)<\/em><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_81 ez-toc-wrap-left counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">N\u1ed9i dung ch\u00ednh<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#1-ten-hoat-chat-va-biet-duoc\" >1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#2-dang-bao-che-%e2%80%93-ham-luong\" >2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#3-video-by-pharmog\" >3. Video by Pharmog:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#4-ung-dung-lam-sang\" >4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng:<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#41-chi-dinh\" >4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#42-lieu-dung-%e2%80%93-cach-dung\" >4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#43-chong-chi-dinh\" >4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#44-than-trong\" >4.4 Th\u1eadn tr\u1ecdng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#45-su-dung-cho-phu-nu-co-thai-va-cho-con-bu\" >4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#46-tac-dung-khong-mong-muon-adr\" >4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#47-huong-dan-cach-xu-tri-adr\" >4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#48-tuong-tac-voi-cac-thuoc-khac\" >4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#49-qua-lieu-va-xu-tri\" >4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#5-co-che-tac-dung-cua-thuoc\" >5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#51-duoc-luc-hoc\" >5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#52-duoc-dong-hoc\" >5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#53-giai-thich\" >5.3 Gi\u1ea3i th\u00edch:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#54-thay-the-thuoc\" >5.4 Thay th\u1ebf thu\u1ed1c :<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#6-phan-thong-tin-kem-theo-cua-thuoc\" >6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#61-danh-muc-ta-duoc\" >6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#62-tuong-ky\" >6.2. T\u01b0\u01a1ng k\u1ef5 :<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#63-bao-quan\" >6.3. B\u1ea3o qu\u1ea3n:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#64-thong-tin-khac\" >6.4. Th\u00f4ng tin kh\u00e1c :<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#65-tai-lieu-tham-khao\" >6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/pharmog.com\/wp\/losartan-losartan-domesco\/#7-nguoi-dang-tai-tac-gia\" >7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<\/a><\/li><\/ul><\/nav><\/div>\n\n<h1><span class=\"ez-toc-section\" id=\"1-ten-hoat-chat-va-biet-duoc\"><\/span>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <\/strong><a href=\"https:\/\/pharmog.com\/wp\/losartan\/\"><strong>Losartan<\/strong><\/a><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u1ed1c \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 AT1 c\u1ee7a angiotensin II. Thu\u1ed1c ch\u1ed1ng t\u0103ng huy\u1ebft \u00e1p<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): C09CA01.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em><\/strong> <a href=\"https:\/\/pharmog.com\/wp\/losartan-cozaar\/\"><strong>Cozaar<\/strong><\/a><\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c:<\/em><\/strong> Losartan<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: C\u00f4ng ty c\u1ed5 ph\u1ea7n xu\u1ea5t nh\u1eadp kh\u1ea9u y t\u1ebf Domesco<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h1><span class=\"ez-toc-section\" id=\"2-dang-bao-che-%e2%80%93-ham-luong\"><\/span>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>Vi\u00ean n\u00e9n bao phim, d\u1ea1ng mu\u1ed1i kali: 25 mg, 50 mg.<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>LOSARTAN 25<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean n\u00e9n c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Losartan Kali<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>25 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"508\" height=\"381\" class=\"wp-image-40121\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2022\/01\/word-image-198.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2022\/01\/word-image-198.png 508w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2022\/01\/word-image-198-300x225.png 300w\" sizes=\"auto, (max-width: 508px) 100vw, 508px\" \/><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>LOSARTAN 50<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean n\u00e9n c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Losartan Kali<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>50 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"516\" height=\"372\" class=\"wp-image-40122\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2022\/01\/word-image-199.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2022\/01\/word-image-199.png 516w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2022\/01\/word-image-199-300x216.png 300w\" sizes=\"auto, (max-width: 516px) 100vw, 516px\" \/><\/p>\n<h1><span class=\"ez-toc-section\" id=\"3-video-by-pharmog\"><\/span>3. Video by Pharmog:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe loading=\"lazy\" title=\"[Pharmog SS1 - T\u1eadp 11] - D\u01b0\u1ee3c l\u00fd v\u1ec1 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/F1Pl4DO5flA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<h1><span class=\"ez-toc-section\" id=\"4-ung-dung-lam-sang\"><\/span>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"41-chi-dinh\"><\/span>4.1. Ch\u1ec9 \u0111\u1ecbnh:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u0110i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p.<\/p>\n<p>Gi\u1ea3m nguy c\u01a1 m\u1eafc v\u00e0 t\u1eed vong tim m\u1ea1ch cho b\u1ec7nh nh\u00e2n t\u0103ng huy\u1ebft \u00e1p c\u00f3 ph\u00ec \u0111\u1ea1i th\u1ea5t tr\u00e1i.<\/p>\n<p>B\u1ea3o v\u1ec7 th\u1eadn cho b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng t\u00fdp 2 c\u00f3 protein ni\u1ec7u<\/p>\n<h2><span class=\"ez-toc-section\" id=\"42-lieu-dung-%e2%80%93-cach-dung\"><\/span>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p>D\u00f9ng u\u1ed1ng, c\u00f3 th\u1ec3 u\u1ed1ng losartan khi \u0111\u00f3i hay no<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p>Li\u1ec1u d\u00f9ng t\u00f9y thu\u1ed9c t\u1eebng ng\u01b0\u1eddi b\u1ec7nh v\u00e0 ph\u1ea3i \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u theo \u0111\u00e1p \u1ee9ng huy\u1ebft \u00e1p. N\u1ebfu kh\u00f4ng ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c huy\u1ebft \u00e1p v\u1edbi li\u1ec1u \u0111\u00e3 d\u00f9ng th\u00ec c\u00e1ch 1 \u2013 2 th\u00e1ng m\u1ed9t l\u1ea7n ph\u1ea3i \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u l\u01b0\u1ee3ng thu\u1ed1c ch\u1ed1ng t\u0103ng huy\u1ebft \u00e1p.<\/p>\n<p>Li\u1ec1u kh\u1edfi \u0111\u1ea7u v\u00e0 duy tr\u00ec \u0111\u1ed1i v\u1edbi ph\u1ea7n l\u1edbn ng\u01b0\u1eddi b\u1ec7nh l\u00e0 50 mg, u\u1ed1ng m\u1ed7i ng\u00e0y m\u1ed9t l\u1ea7n. T\u00e1c d\u1ee5ng t\u1ed1i \u0111a \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p \u0111\u1ea1t \u0111\u01b0\u1ee3c 3 \u2013 6 tu\u1ea7n sau khi b\u1eaft \u0111\u1ea7u d\u00f9ng thu\u1ed1c. C\u00f3 th\u1ec3 t\u0103ng li\u1ec1u l\u00ean t\u1edbi 100 mg, ng\u00e0y m\u1ed9t l\u1ea7n.<\/p>\n<p>V\u1edbi ng\u01b0\u1eddi b\u1ec7nh gi\u1ea3m th\u1ec3 t\u00edch d\u1ecbch tu\u1ea7n ho\u00e0n (v\u00ed d\u1ee5 ng\u01b0\u1eddi \u0111i\u1ec1u tr\u1ecb thu\u1ed1c l\u1ee3i ni\u1ec7u li\u1ec1u cao), n\u00ean xem x\u00e9t d\u00f9ng li\u1ec1u kh\u1edfi \u0111\u1ea7u l\u00e0 25 mg, m\u1ed7i ng\u00e0y m\u1ed9t l\u1ea7n.<\/p>\n<p>Kh\u00f4ng c\u1ea7n ph\u1ea3i \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u kh\u1edfi \u0111\u1ea7u cho ng\u01b0\u1eddi b\u1ec7nh cao tu\u1ed5i ho\u1eb7c ng\u01b0\u1eddi b\u1ec7nh suy th\u1eadn k\u1ec3 c\u1ea3 ng\u01b0\u1eddi \u0111ang th\u1ea9m ph\u00e2n m\u00e1u. C\u1ea7n xem x\u00e9t d\u00f9ng li\u1ec1u th\u1ea5p h\u01a1n cho ng\u01b0\u1eddi b\u1ec7nh c\u00f3 ti\u1ec1n s\u1eed suy gan.<\/p>\n<p>N\u1ebfu d\u00f9ng losartan \u0111\u01a1n \u0111\u1ed9c m\u00e0 kh\u00f4ng ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c huy\u1ebft \u00e1p, c\u00f3 th\u1ec3 th\u00eam thu\u1ed1c l\u1ee3i ni\u1ec7u li\u1ec1u th\u1ea5p. Hydroclorothiazid ch\u1ee9ng t\u1ecf c\u00f3 t\u00e1c d\u1ee5ng c\u1ed9ng l\u1ef1c. C\u00f3 th\u1ec3 d\u00f9ng losartan c\u00f9ng v\u1edbi c\u00e1c thu\u1ed1c ch\u1ed1ng t\u0103ng huy\u1ebft \u00e1p kh\u00e1c.<\/p>\n<p>Kh\u00f4ng \u0111\u01b0\u1ee3c ph\u1ed1i h\u1ee3p losartan v\u1edbi c\u00e1c thu\u1ed1c l\u1ee3i ni\u1ec7u gi\u1eef kali do nguy c\u01a1 t\u0103ng kali huy\u1ebft.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"43-chong-chi-dinh\"><\/span>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Qu\u00e1 m\u1eabn c\u1ea3m v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c<\/p>\n<h2><span class=\"ez-toc-section\" id=\"44-than-trong\"><\/span>4.4 Th\u1eadn tr\u1ecdng:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>M\u1eabn c\u1ea3m: Ph\u00f9 m\u1ea1ch.<\/p>\n<p>H\u1ea1 huy\u1ebft \u00e1p v\u00e0 m\u1ea5t c\u00e2n b\u1eb1ng d\u1ecbch, \u0111i\u1ec7n gi\u1ea3i: \u1ede ng\u01b0\u1eddi b\u1ec7nh m\u1ea5t th\u1ec3 t\u00edch d\u1ecbch tu\u1ea7n ho\u00e0n (nh\u01b0 ng\u01b0\u1eddi \u0111i\u1ec1u tr\u1ecb thu\u1ed1c l\u1ee3i ni\u1ec7u li\u1ec1u cao) c\u00f3 th\u1ec3 x\u1ea3y ra h\u1ea1 huy\u1ebft \u00e1p tri\u1ec7u ch\u1ee9ng. Ph\u1ea3i \u0111i\u1ec1u ch\u1ec9nh nh\u1eefng t\u00ecnh tr\u1ea1ng n\u00e0y tr\u01b0\u1edbc khi d\u00f9ng thu\u1ed1c, ho\u1eb7c ph\u1ea3i d\u00f9ng li\u1ec1u kh\u1edfi \u0111\u1ea7u th\u1ea5p h\u01a1n. M\u1ea5t c\u00e2n b\u1eb1ng \u0111i\u1ec7n gi\u1ea3i th\u01b0\u1eddng g\u1eb7p \u1edf ng\u01b0\u1eddi b\u1ec7nh suy th\u1eadn, c\u00f3 k\u00e8m ti\u1ec3u \u0111\u01b0\u1eddng ho\u1eb7c kh\u00f4ng.<\/p>\n<p>Suy ch\u1ee9c n\u0103ng gan: D\u1ef1a tr\u00ean d\u1eef li\u1ec7u d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc \u0111\u00e3 ch\u1ee9ng minh c\u00f3 s\u1ef1 t\u0103ng n\u1ed3ng \u0111\u1ed9 losartan trong huy\u1ebft t\u01b0\u01a1ng \u1edf ng\u01b0\u1eddi b\u1ec7nh x\u01a1 gan, c\u1ea7n xem x\u00e9t d\u00f9ng li\u1ec1u th\u1ea5p h\u01a1n cho ng\u01b0\u1eddi b\u1ec7nh c\u00f3 ti\u1ec1n s\u1eed suy gan.<\/p>\n<p>Suy ch\u1ee9c n\u0103ng th\u1eadn: Do h\u1eadu qu\u1ea3 \u1ee9c ch\u1ebf h\u1ec7 th\u1ed1ng renin \u2013 angiotensin, \u0111\u00e3 c\u00f3 b\u00e1o c\u00e1o v\u1ec1 nh\u1eefng thay \u0111\u1ed5i trong ch\u1ee9c n\u0103ng th\u1eadn, bao g\u1ed3m suy th\u1eadn \u1edf ng\u01b0\u1eddi m\u1eabn c\u1ea3m, nh\u1eefng thay \u0111\u1ed5i n\u00e0y trong ch\u1ee9c n\u0103ng th\u1eadn c\u00f3 th\u1ec3 h\u1ed3i ph\u1ee5c \u0111\u01b0\u1ee3c khi ng\u1eebng thu\u1ed1c.<\/p>\n<p>S\u1eed d\u1ee5ng thu\u1ed1c cho tr\u1ebb em: V\u1edbi nh\u1eefng tr\u1ebb em c\u00f3 th\u1ec3 nu\u1ed1t \u0111\u01b0\u1ee3c vi\u00ean thu\u1ed1c, li\u1ec1u \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o l\u00e0 25 mg 1 l\u1ea7n\/ng\u00e0y \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n n\u1eb7ng \u226520 kg \u0111\u1ebfn &lt; 50 kg, c\u00f3 th\u1ec3 t\u0103ng li\u1ec1u \u0111\u1ebfn t\u1ed1i \u0111a l\u00e0 50 mg ng\u00e0y 1 l\u1ea7n. \u1ede nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 c\u00e2n n\u1eb7ng &gt; 50 kg, li\u1ec1u kh\u1edfi \u0111\u1ea7u l\u00e0 50 mg, ng\u00e0y 1 l\u1ea7n, c\u00f3 th\u1ec3 t\u0103ng li\u1ec1u \u0111\u1ebfn t\u1ed1i \u0111a 100 mg, ng\u00e0y 1 l\u1ea7n. Tr\u01b0\u1edbc khi d\u00f9ng thu\u1ed1c cho tr\u1ebb em, n\u00ean \u0111i\u1ec1u ch\u1ec9nh t\u00ecnh tr\u1ea1ng gi\u1ea3m th\u1ec3 t\u00edch tu\u1ea7n ho\u00e0n. Kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng thu\u1ed1c 2 \u1edf tr\u1ebb em c\u00f3 \u0111\u1ed9 l\u1ecdc c\u1ea7u th\u1eadn &lt; 30 ml\/ph\u00fat\/1,73 m , \u1edf tr\u1ebb em b\u1ecb suy gan ho\u1eb7c \u1edf tr\u1ebb s\u01a1 sinh v\u00ec ch\u01b0a c\u00f3 d\u1eef li\u1ec7u.<\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>Th\u1eadn tr\u1ecdng khi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c v\u00ec thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y ch\u00f3ng m\u1eb7t, suy nh\u01b0\u1ee3c, m\u1ec7t m\u1ecfi v\u00e0 cho\u00e1ng v\u00e1ng.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h2><span class=\"ez-toc-section\" id=\"45-su-dung-cho-phu-nu-co-thai-va-cho-con-bu\"><\/span>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: D<\/p>\n<p>US FDA pregnancy category: D<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>D\u00f9ng c\u00e1c thu\u1ed1c t\u00e1c d\u1ee5ng tr\u1ef1c ti\u1ebfp l\u00ean h\u1ec7 th\u1ed1ng renin \u2013 angiotensin trong ba th\u00e1ng gi\u1eefa v\u00e0 ba th\u00e1ng cu\u1ed1i c\u1ee7a thai k\u1ef3 c\u00f3 th\u1ec3 g\u00e2y \u00edt n\u01b0\u1edbc \u1ed1i, h\u1ea1 huy\u1ebft \u00e1p, v\u00f4 ni\u1ec7u, thi\u1ec3u ni\u1ec7u, bi\u1ebfn d\u1ea1ng s\u1ecd m\u1eb7t v\u00e0 t\u1eed vong \u1edf tr\u1ebb s\u01a1 sinh. M\u1eb7c d\u00f9 vi\u1ec7c ch\u1ec9 d\u00f9ng thu\u1ed1c \u1edf ba th\u00e1ng \u0111\u1ea7u c\u1ee7a thai k\u1ef3 ch\u01b0a th\u1ea5y c\u00f3 li\u00ean quan \u0111\u1ebfn nguy c\u01a1 cho thai nhi, nh\u01b0ng d\u00f9 sao khi ph\u00e1t hi\u1ec7n c\u00f3 thai, ph\u1ea3i ng\u1eebng losartan c\u00e0ng s\u1edbm c\u00e0ng t\u1ed1t.<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>Kh\u00f4ng bi\u1ebft losartan c\u00f3 ti\u1ebft v\u00e0o s\u1eefa m\u1eb9 hay kh\u00f4ng, nh\u01b0ng c\u00f3 nh\u1eefng l\u01b0\u1ee3ng \u0111\u00e1ng k\u1ec3 losartan v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh c\u1ee7a thu\u1ed1c trong s\u1eefa c\u1ee7a chu\u1ed9t c\u1ed1ng. Do ti\u1ec1m n\u0103ng c\u00f3 h\u1ea1i cho tr\u1ebb nh\u1ecf \u0111ang b\u00fa m\u1eb9, ph\u1ea3i quy\u1ebft \u0111\u1ecbnh ng\u1eebng cho con b\u00fa ho\u1eb7c ng\u1eebng thu\u1ed1c, c\u00f3 t\u00ednh \u0111\u1ebfn t\u1ea7m quan tr\u1ecdng c\u1ee7a thu\u1ed1c \u0111\u1ed1i v\u1edbi ng\u01b0\u1eddi m\u1eb9<\/p>\n<h2><span class=\"ez-toc-section\" id=\"46-tac-dung-khong-mong-muon-adr\"><\/span>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Ph\u1ea7n l\u1edbn c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n \u0111\u1ec1u nh\u1eb9 v\u00e0 m\u1ea5t d\u1ea7n v\u1edbi th\u1eddi gian.<\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p: H\u1ea1 huy\u1ebft \u00e1p, m\u1ea5t ng\u1ee7, cho\u00e1ng v\u00e1ng, t\u0103ng kali huy\u1ebft, ti\u00eau ch\u1ea3y, kh\u00f3 ti\u00eau, h\u1ea1 nh\u1eb9 hemoglobin v\u00e0 hematocrit, \u0111au l\u01b0ng, \u0111au ch\u00e2n, \u0111au c\u01a1, h\u1ea1 acid uric huy\u1ebft (khi d\u00f9ng li\u1ec1u cao), ho (\u00edt h\u01a1n khi d\u00f9ng c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf ACE), sung huy\u1ebft m\u0169i, vi\u00eam xoang.<\/p>\n<p>\u00cdt g\u1eb7p: H\u1ea1 huy\u1ebft \u00e1p th\u1ebf \u0111\u1ee9ng, \u0111au ng\u1ef1c, bl\u1ed1c AV \u0111\u1ed9 II, tr\u1ed1ng ng\u1ef1c, nh\u1ecbp ch\u1eadm xoang, nh\u1ecbp tim nhanh, ph\u00f9 m\u1eb7t, \u0111\u1ecf m\u1eb7t, lo \u00e2u, m\u1ea5t \u0111i\u1ec1u h\u00f2a, l\u00fa l\u1eabn, tr\u1ea7m c\u1ea3m, \u0111au n\u1eeda \u0111\u1ea7u, \u0111au \u0111\u1ea7u, r\u1ed1i lo\u1ea1n gi\u1ea5c ng\u1ee7, s\u1ed1t, ch\u00f3ng m\u1eb7t, r\u1ee5ng t\u00f3c, vi\u00eam da, da kh\u00f4, ban \u0111\u1ecf, nh\u1ea1y c\u1ea3m \u00e1nh s\u00e1ng, ng\u1ee9a, m\u00e0y \u0111ay, v\u1ebft b\u1ea7m, ngo\u1ea1i ban, b\u1ec7nh g\u00fat, ch\u00e1n \u0103n, t\u00e1o b\u00f3n, \u0111\u1ea7y h\u01a1i, n\u00f4n, m\u1ea5t v\u1ecb gi\u00e1c, vi\u00eam d\u1ea1 d\u00e0y, b\u1ea5t l\u1ef1c, gi\u1ea3m t\u00ecnh d\u1ee5c, \u0111\u00e1i nhi\u1ec1u, \u0111\u00e1i \u0111\u00eam, t\u0103ng nh\u1eb9 c\u00e1c th\u1eed nghi\u1ec7m v\u1ec1 ch\u1ee9c n\u0103ng gan v\u00e0 t\u0103ng nh\u1eb9 bilirubin, d\u1ecb c\u1ea3m, run, \u0111au x\u01b0\u01a1ng, y\u1ebfu c\u01a1, ph\u00f9 kh\u1edbp, \u0111au x\u01a1 c\u01a1, nh\u00ecn m\u1edd, vi\u00eam k\u1ebft m\u1ea1c, gi\u1ea3m th\u1ecb l\u1ef1c, n\u00f3ng r\u00e1t v\u00e0 nh\u1ee9c m\u1eaft, \u00f9 tai, nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng ni\u1ec7u, t\u0103ng nh\u1eb9 creatinin ho\u1eb7c ur\u00ea, kh\u00f3 th\u1edf, vi\u00eam ph\u1ebf qu\u1ea3n, ch\u1ea3y m\u00e1u cam, vi\u00eam m\u0169i, sung huy\u1ebft \u0111\u01b0\u1eddng th\u1edf, kh\u00f3 ch\u1ecbu \u1edf h\u1ecdng, to\u00e1t m\u1ed3 h\u00f4i<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<h2><span class=\"ez-toc-section\" id=\"47-huong-dan-cach-xu-tri-adr\"><\/span>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Gi\u1ea3m li\u1ec1u ho\u1eb7c d\u1eebng thu\u1ed1c khi xu\u1ea5t hi\u1ec7n c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n.<\/p>\n<p>Ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c. V\u1edbi c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i nh\u1eb9, th\u01b0\u1eddng ch\u1ec9 c\u1ea7n ng\u1eebng thu\u1ed1c. Tr\u01b0\u1eddng h\u1ee3p m\u1eabn c\u1ea3m n\u1eb7ng ho\u1eb7c ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, c\u1ea7n ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 (gi\u1eef tho\u00e1ng kh\u00ed v\u00e0 d\u00f9ng epinephrin, th\u1edf oxygen, d\u00f9ng kh\u00e1ng histamin, corticoid&#8230;).<\/p>\n<h2><span class=\"ez-toc-section\" id=\"48-tuong-tac-voi-cac-thuoc-khac\"><\/span>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Losartan ph\u1ed1i h\u1ee3p c\u00f9ng v\u1edbi cimetidin l\u00e0m t\u0103ng di\u1ec7n t\u00edch d\u01b0\u1edbi \u0111\u01b0\u1eddng cong (AUC) c\u1ee7a losartan kho\u1ea3ng 18 %, nh\u01b0ng kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh c\u1ee7a losartan.<\/p>\n<p>Losartan ph\u1ed1i h\u1ee3p c\u00f9ng v\u1edbi phenobarbital l\u00e0m gi\u1ea3m kho\u1ea3ng 20 % AUC c\u1ee7a losartan v\u00e0 c\u1ee7a ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh<\/p>\n<p>C\u00e1c thu\u1ed1c l\u1ee3i ni\u1ec7u gi\u1eef kali (nh\u01b0 spironolacton, triamteren, amilorid), b\u1ed5 sung kali, c\u00e1c ch\u1ea5t thay th\u1ebf mu\u1ed1i c\u00f3 ch\u1ee9a kali, kh\u00f4ng \u0111\u01b0\u1ee3c ph\u1ed1i h\u1ee3p v\u1edbi losartan v\u00ec nguy c\u01a1 t\u0103ng kali trong huy\u1ebft thanh.<\/p>\n<p>Hi\u1ec7u qu\u1ea3 gi\u1ea3m huy\u1ebft \u00e1p c\u00f3 th\u1ec3 b\u1ecb gi\u1ea3m khi ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1ng vi\u00eam kh\u00f4ng steroid.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"49-qua-lieu-va-xu-tri\"><\/span>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>T\u00e0i li\u1ec7u v\u1ec1 qu\u00e1 li\u1ec1u \u1edf ng\u01b0\u1eddi c\u00f2n h\u1ea1n ch\u1ebf. Bi\u1ec3u hi\u1ec7n v\u1ec1 qu\u00e1 li\u1ec1u c\u00f3 th\u1ec3 hay g\u1eb7p nh\u1ea5t c\u00f3 th\u1ec3 l\u00e0 h\u1ea1 huy\u1ebft \u00e1p v\u00e0 nh\u1ecbp tim nhanh, c\u0169ng c\u00f3 th\u1ec3 x\u1ea3y ra tim \u0111\u1eadp ch\u1eadm do k\u00edch th\u00edch th\u1ea7n kinh ph\u00f3 giao c\u1ea3m (d\u00e2y th\u1ea7n kinh ph\u1ebf v\u1ecb). N\u1ebfu h\u1ea1 huy\u1ebft \u00e1p tri\u1ec7u ch\u1ee9ng x\u1ea3y ra, c\u1ea7n ti\u1ebfn h\u00e0nh c\u00e1c bi\u1ec7n ph\u00e1p \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3.<\/p>\n<p>Kh\u00f4ng th\u1ec3 lo\u1ea1i b\u1ecf losartan v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f2n ho\u1ea1t t\u00ednh c\u1ee7a losartan b\u1eb1ng th\u1ea9m ph\u00e2n l\u1ecdc m\u00e1u..<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h1><span class=\"ez-toc-section\" id=\"5-co-che-tac-dung-cua-thuoc\"><\/span>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"51-duoc-luc-hoc\"><\/span>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Losartan l\u00e0 ch\u1ea5t \u0111\u1ea7u ti\u00ean c\u1ee7a nh\u00f3m thu\u1ed1c ch\u1ed1ng t\u0103ng huy\u1ebft \u00e1p m\u1edbi, \u0111\u00f3 l\u00e0 m\u1ed9t ch\u1ea5t \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 (t\u00fdp AT 1) angiotensin II.<\/p>\n<p>Angiotensin II, t\u1ea1o th\u00e0nh t\u1eeb angiotensin I trong ph\u1ea3n \u1ee9ng do men chuy\u1ec3n angiotensin (ACE) x\u00fac t\u00e1c, l\u00e0 m\u1ed9t ch\u1ea5t co m\u1ea1ch m\u1ea1nh; \u0111\u00f3 l\u00e0 hormon k\u00edch ho\u1ea1t m\u1ea1ch ch\u1ee7 y\u1ebfu c\u1ee7a h\u1ec7 th\u1ed1ng renin-angiotensin v\u00e0 l\u00e0 m\u1ed9t th\u00e0nh ph\u1ea7n quan tr\u1ecdng trong sinh l\u00fd b\u1ec7nh h\u1ecdc c\u1ee7a t\u0103ng huy\u1ebft \u00e1p. Angiotensin II c\u0169ng k\u00edch th\u00edch v\u1ecf tuy\u1ebfn th\u01b0\u1ee3ng th\u1eadn ti\u1ebft aldosteron.<\/p>\n<p>Losartan v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh c\u00f3 ho\u1ea1t t\u00ednh ch\u1eb9n t\u00e1c d\u1ee5ng co m\u1ea1ch v\u00e0 ti\u1ebft aldosteron c\u1ee7a angiotensin II b\u1eb1ng c\u00e1ch ng\u0103n c\u1ea3n c\u00f3 ch\u1ecdn l\u1ecdc angiotensin II, kh\u00f4ng cho g\u1eafn v\u00e0o th\u1ee5 th\u1ec3 AT c\u00f3 trong nhi\u1ec1u m\u00f4 (th\u00ed d\u1ee5 c\u01a1 tr\u01a1n m\u1ea1ch m\u00e1u, tuy\u1ebfn th\u01b0\u1ee3ng th\u1eadn). Trong nhi\u1ec1u m\u00f4, c\u0169ng th\u1ea5y c\u00f3 th\u1ee5 th\u1ec3 AT2 nh\u01b0ng kh\u00f4ng r\u00f5 th\u1ee5 th\u1ec3 n\u00e0y c\u00f3 li\u00ean quan g\u00ec \u0111\u1ebfn \u0111i\u1ec1u h\u00f2a tim m\u1ea1ch hay kh\u00f4ng. C\u1ea3 losartan v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh c\u00f3 ho\u1ea1t t\u00ednh \u0111\u1ec1u kh\u00f4ng bi\u1ec3u l\u1ed9 t\u00e1c d\u1ee5ng ch\u1ee7 v\u1eadn c\u1ee5c b\u1ed9 \u1edf th\u1ee5 th\u1ec3 AT1 v\u00e0 \u0111\u1ec1u c\u00f3 \u00e1i l\u1ef1c v\u1edbi th\u1ee5 th\u1ec3 AT1 l\u1edbn h\u01a1n nhi\u1ec1u (kho\u1ea3ng 1000 l\u1ea7n) so v\u1edbi th\u1ee5 th\u1ec3 AT2.<\/p>\n<p>Losartan l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf c\u1ea1nh tranh, thu\u1eadn ngh\u1ecbch c\u1ee7a th\u1ee5 th\u1ec3 AT 1. Ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh c\u1ee7a thu\u1ed1c m\u1ea1nh h\u01a1n t\u1eeb 10 \u0111\u1ebfn 40 l\u1ea7n so v\u1edbi losartan, t\u00ednh theo tr\u1ecdng l\u01b0\u1ee3ng v\u00e0 l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf kh\u00f4ng c\u1ea1nh tranh, thu\u1eadn ngh\u1ecbch c\u1ee7a th\u1ee5 th\u1ec3 AT1 . C\u00e1c ch\u1ea5t \u0111\u1ed1i kh\u00e1ng angiotensin II c\u0169ng c\u00f3 c\u00e1c t\u00e1c d\u1ee5ng huy\u1ebft \u0111\u1ed9ng h\u1ecdc nh\u01b0 c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf ACE, nh\u01b0ng kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n ph\u1ed5 bi\u1ebfn c\u1ee7a c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf ACE l\u00e0 ho khan.<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>Losartan c\u00f3 ho\u1ea1t t\u00ednh ng\u0103n ch\u1eb7n t\u00e1c \u0111\u1ed9ng g\u00e2y co m\u1ea1ch v\u00e0 g\u00e2y ti\u1ebft aldosteron c\u1ee7a angiotensin II b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf c\u00f3 ch\u1ecdn l\u1ecdc s\u1ef1 g\u1eafn k\u1ebft gi\u1eefa angiotensin II v\u00e0 th\u1ee5 th\u1ec3 AT1 c\u00f3 trong nhi\u1ec1u m\u00f4 (v\u00ed d\u1ee5: c\u01a1 tr\u01a1n m\u1ea1ch m\u00e1u, tuy\u1ebfn th\u01b0\u1ee3ng th\u1eadn). Losartan kh\u00f4ng \u1ee9c ch\u1ebf ACE (kininase II, enzym chuy\u1ec3n angiotensin I th\u00e0nh angiotensin II v\u00e0 ph\u00e2n h\u1ee7y bradykinin), ch\u00fang c\u0169ng kh\u00f4ng g\u1eafn k\u1ebft hay ng\u0103n ch\u1eb7n c\u00e1c th\u1ee5 th\u1ec3 c\u1ee7a c\u00e1c hormon kh\u00e1c hay c\u00e1c k\u00eanh ion c\u00f3 vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c \u0111i\u1ec1u h\u00f2a h\u1ec7 tim m\u1ea1ch..<\/p>\n<p><a href=\"https:\/\/www.youtube.com\/watch?v=F1Pl4DO5flA\"><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/a><\/p>\n<h2><span class=\"ez-toc-section\" id=\"52-duoc-dong-hoc\"><\/span>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Sau khi u\u1ed1ng, losartan h\u1ea5p thu t\u1ed1t v\u00e0 chuy\u1ec3n h\u00f3a b\u01b0\u1edbc \u0111\u1ea7u nhi\u1ec1u qua gan nh\u1edd c\u00e1c men cytochrom P 450. Sinh kh\u1ea3 d\u1ee5ng c\u1ee7a losartan x\u1ea5p x\u1ec9 33 %. Kho\u1ea3ng 14 % li\u1ec1u losartan u\u1ed1ng chuy\u1ec3n th\u00e0nh ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh, ch\u1ea5t n\u00e0y \u0111\u1ea3m nhi\u1ec7m ph\u1ea7n l\u1edbn t\u00ednh \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 angiotensin II. Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a losartan kho\u1ea3ng 2 gi\u1edd v\u00e0 c\u1ee7a ch\u1ea5t chuy\u1ec3n h\u00f3a kho\u1ea3ng 6-9 gi\u1edd. N\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trung b\u00ecnh c\u1ee7a losartan \u0111\u1ea1t trong v\u00f2ng 1 gi\u1edd v\u00e0 c\u1ee7a ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh trong v\u00f2ng 3-4 gi\u1edd.<\/p>\n<p>Losartan v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh \u0111\u1ec1u li\u00ean k\u1ebft nhi\u1ec1u v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng, ch\u1ee7 y\u1ebfu l\u00e0 albumin v\u00e0 ch\u00fang kh\u00f4ng qua h\u00e0ng r\u00e0o m\u00e1u \u2013 n\u00e3o. Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 c\u1ee7a losartan kho\u1ea3ng 34 l\u00edt v\u00e0 c\u1ee7a ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh kho\u1ea3ng 12 l\u00edt. \u0110\u1ed9 thanh th\u1ea3i to\u00e0n ph\u1ea7n trong huy\u1ebft t\u01b0\u01a1ng c\u1ee7a losartan kho\u1ea3ng 600 ml\/ph\u00fat v\u00e0 c\u1ee7a ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh l\u00e0 50 ml\/ph\u00fat; \u0111\u1ed9 thanh th\u1ea3i c\u1ee7a ch\u00fang \u1edf th\u1eadn t\u01b0\u01a1ng \u1ee9ng v\u1edbi kho\u1ea3ng 75 ml\/ph\u00fat v\u00e0 25 ml\/ph\u00fat. Sau khi u\u1ed1ng losartan ghi d\u1ea5u 14C, thu l\u1ea1i kho\u1ea3ng 35 % \u0111\u1ed9 ph\u00f3ng x\u1ea1 trong n\u01b0\u1edbc ti\u1ec3uv\u00e0 kho\u1ea3ng 60 % trong ph\u00e2n.<\/p>\n<p>\u1ede ng\u01b0\u1eddi b\u1ec7nh x\u01a1 gan t\u1eeb nh\u1eb9 \u0111\u1ebfn v\u1eeba, di\u1ec7n t\u00edch d\u01b0\u1edbi \u0111\u01b0\u1eddng cong (AUC) c\u1ee7a losartan v\u00e0 c\u1ee7a ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh cao h\u01a1n, t\u01b0\u01a1ng \u1ee9ng g\u1ea5p 5 l\u1ea7n v\u00e0 2 l\u1ea7n so v\u1edbi ng\u01b0\u1eddi b\u1ec7nh c\u00f3 gan b\u00ecnh th\u01b0\u1eddng..<\/p>\n<h2><span class=\"ez-toc-section\" id=\"53-giai-thich\"><\/span>5.3 Gi\u1ea3i th\u00edch:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"54-thay-the-thuoc\"><\/span>5.4 Thay th\u1ebf thu\u1ed1c :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h1><span class=\"ez-toc-section\" id=\"6-phan-thong-tin-kem-theo-cua-thuoc\"><\/span>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"61-danh-muc-ta-duoc\"><\/span>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Lactose khan, Avicel PH102, Natri croscarmellose, Magnesi stearat, Hydroxypropyl methylcellulose 15cP, Hydroxypropyl methylcellulose 6cP, Polyethylen glycol 6000, Colloidal silicon dioxid A200, Talc, Titan dioxid, M\u00e0u Sicovit red.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"62-tuong-ky\"><\/span>6.2. T\u01b0\u01a1ng k\u1ef5 :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Kh\u00f4ng \u00e1p d\u1ee5ng.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"63-bao-quan\"><\/span>6.3. B\u1ea3o qu\u1ea3n:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>N\u01a1i kh\u00f4, tr\u00e1nh \u00e1nh s\u00e1ng, nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30\u00b0C.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"64-thong-tin-khac\"><\/span>6.4. Th\u00f4ng tin kh\u00e1c :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Kh\u00f4ng c\u00f3.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"65-tai-lieu-tham-khao\"><\/span>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>HDSD Thu\u1ed1c Losartan Domesco (2016).<\/p>\n<h1><span class=\"ez-toc-section\" id=\"7-nguoi-dang-tai-tac-gia\"><\/span>7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p>B\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c s\u01b0u t\u1ea7m ho\u1eb7c vi\u1ebft b\u1edfi: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-tac-gia-bac-sy-do-my-linh\/\">B\u00e1c s\u0129 nhi khoa &#8211; \u0110\u1ed7 M\u1ef9 Linh.<\/a><\/p>\n<p>Ki\u1ec3m duy\u1ec7t , hi\u1ec7u \u0111\u00ednh v\u00e0 \u0111\u0103ng t\u1ea3i: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-ve-pharmog-team\/\">PHARMOG TEAM<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Losartan Domesco l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Losartan Domesco (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;) 1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Losartan Ph\u00e2n lo\u1ea1i: Thu\u1ed1c \u0111\u1ed1i kh\u00e1ng [&hellip;]<\/p>\n","protected":false},"author":8612,"featured_media":40121,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[1653],"class_list":["post-40113","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-losartan"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/40113","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/8612"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=40113"}],"version-history":[{"count":1,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/40113\/revisions"}],"predecessor-version":[{"id":40137,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/40113\/revisions\/40137"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/40121"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=40113"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=40113"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=40113"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}