{"id":35289,"date":"2021-09-18T15:54:13","date_gmt":"2021-09-18T08:54:13","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=35289"},"modified":"2025-01-07T22:50:49","modified_gmt":"2025-01-07T15:50:49","slug":"sertraline-clealine","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/sertraline-clealine\/","title":{"rendered":"Sertraline &#8211; Clealine"},"content":{"rendered":"<p><em>Thu\u1ed1c Clealine l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Clealine (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;)<\/em><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_81 ez-toc-wrap-left counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">N\u1ed9i dung ch\u00ednh<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#1-ten-hoat-chat-va-biet-duoc\" >1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#2-dang-bao-che-%e2%80%93-ham-luong\" >2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#3-video-by-pharmog\" >3. Video by Pharmog:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#4-ung-dung-lam-sang\" >4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng:<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#41-chi-dinh\" >4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#42-lieu-dung-%e2%80%93-cach-dung\" >4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#43-chong-chi-dinh\" >4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#44-than-trong\" >4.4 Th\u1eadn tr\u1ecdng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#45-su-dung-cho-phu-nu-co-thai-va-cho-con-bu\" >4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#46-tac-dung-khong-mong-muon-adr\" >4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#47-huong-dan-cach-xu-tri-adr\" >4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#48-tuong-tac-voi-cac-thuoc-khac\" >4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#49-qua-lieu-va-xu-tri\" >4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#5-co-che-tac-dung-cua-thuoc\" >5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#51-duoc-luc-hoc\" >5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#52-duoc-dong-hoc\" >5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#53-giai-thich\" >5.3 Gi\u1ea3i th\u00edch:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#54-thay-the-thuoc\" >5.4 Thay th\u1ebf thu\u1ed1c :<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#6-phan-thong-tin-kem-theo-cua-thuoc\" >6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#61-danh-muc-ta-duoc\" >6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#62-tuong-ky\" >6.2. T\u01b0\u01a1ng k\u1ef5 :<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#63-bao-quan\" >6.3. B\u1ea3o qu\u1ea3n:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#64-thong-tin-khac\" >6.4. Th\u00f4ng tin kh\u00e1c :<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#65-tai-lieu-tham-khao\" >6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/pharmog.com\/wp\/sertraline-clealine\/#7-nguoi-dang-tai-tac-gia\" >7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<\/a><\/li><\/ul><\/nav><\/div>\n\n<h1><span class=\"ez-toc-section\" id=\"1-ten-hoat-chat-va-biet-duoc\"><\/span>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <\/strong><a href=\"https:\/\/pharmog.com\/wp\/sertraline\/\"><strong>Sertraline<\/strong><\/a><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m lo\u1ea1i \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc t\u00e1i h\u1ea5p thu serotonin.<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): N06AB06.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em><\/strong> <a href=\"https:\/\/pharmog.com\/wp\/sertraline-zoloft\/\">Zoloft<\/a><\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c:<\/em><\/strong> Clealine<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: Atlantic Pharma- Producoes Farmaceuticas S.A (Fab. Abrunheira)<br \/>\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" crossorigin=\"anonymous\"><\/script> <ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins> <script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h1><span class=\"ez-toc-section\" id=\"2-dang-bao-che-%e2%80%93-ham-luong\"><\/span>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>Vi\u00ean n\u00e9n bao phim: 50 mg v\u00e0 100 mg.<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>CLEALINE 50mg<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean n\u00e9n bao phim c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Sertraline<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>50 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"524\" height=\"370\" class=\"wp-image-35290\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/09\/word-image-5.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/09\/word-image-5.png 524w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/09\/word-image-5-300x212.png 300w\" sizes=\"auto, (max-width: 524px) 100vw, 524px\" \/><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>CLEALINE 100mg<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean n\u00e9n bao phim c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Sertraline<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>100 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"584\" height=\"402\" class=\"wp-image-35291\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/09\/word-image-6.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/09\/word-image-6.png 584w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/09\/word-image-6-300x207.png 300w\" sizes=\"auto, (max-width: 584px) 100vw, 584px\" \/><\/p>\n<h1><span class=\"ez-toc-section\" id=\"3-video-by-pharmog\"><\/span>3. Video by Pharmog:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<h1><span class=\"ez-toc-section\" id=\"4-ung-dung-lam-sang\"><\/span>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"41-chi-dinh\"><\/span>4.1. Ch\u1ec9 \u0111\u1ecbnh:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u0110i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng tr\u1ea7m c\u1ea3m, bao g\u1ed3m tr\u1ea7m c\u1ea3m \u0111i k\u00e8m b\u1edfi c\u00e1c tri\u1ec7u ch\u1ee9ng lo \u00e2u, \u1edf c\u00e1c b\u1ec7nh nh\u00e2n c\u00f3 hay kh\u00f4ng c\u00f3 ti\u1ec1n s\u1eed ch\u1ee9ng h\u01b0ng c\u1ea3m.<\/p>\n<p>Sau khi c\u00f3 nh\u1eefng \u0111\u00e1p \u1ee9ng t\u1ed1t, vi\u1ec7c \u0111i\u1ec1u tr\u1ecb ti\u1ebfp t\u1ee5c v\u1edbi sertraline mang l\u1ea1i hi\u1ec7u qu\u1ea3 trong vi\u1ec7c ng\u0103n ng\u1eeba s\u1ef1 kh\u1ecfi ph\u00e1t l\u1ea1i c\u1ee7a b\u1ec7nh tr\u1ea7m c\u1ea3m ho\u1eb7c s\u1ef1 t\u00e1i ph\u00e1t c\u00e1c giai \u0111o\u1ea1n tr\u1ea7m c\u1ea3m ti\u1ebfp theo.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb r\u1ed1i l\u1ecdan c\u01b0\u1ee1ng b\u1ee9c \u00e1m \u1ea3nh (OCD). Ti\u1ebfp theo s\u1ef1 \u0111\u00e1p \u1ee9ng ban \u0111\u1ea7u sertraline duy tr\u00ec hi\u1ec7u qu\u1ea3 k\u00e9o d\u00e0i, an to\u00e0n v\u00e0 \u0111\u1ed9 dung n\u1ea1p t\u1ed1t trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb k\u00e9o d\u00e0i \u0111\u1ebfn 2 n\u0103m r\u1ed1i lo\u1ea1n c\u01b0\u1ee1ng b\u1ee9c \u00e1m \u1ea3nh (OCD).<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh nh\u00e2n nhi khoa b\u1ecb r\u1ed1i lo\u1ea1n c\u01b0\u1ee1ng b\u1ee9c \u00e1m \u1ea3nh (OCD).<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n ho\u1ea3ng lo\u1ea1n, c\u00f3 hay kh\u00f4ng c\u00f3 ch\u1ee9ng ho\u1ea3ng s\u1ee3 kho\u1ea3ng r\u1ed9ng.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n stress sau ch\u1ea5n th\u01b0\u01a1ng (PTSD)<\/p>\n<h2><span class=\"ez-toc-section\" id=\"42-lieu-dung-%e2%80%93-cach-dung\"><\/span>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p>Sertraline n\u00ean \u0111\u01b0\u1ee3c d\u00f9ng m\u1ed9t l\u1ea7n m\u1ed7i ng\u00e0y v\u00e0o bu\u1ed5i s\u00e1ng ho\u1eb7c bu\u1ed5i t\u1ed1i, d\u00f9ng c\u00f9ng th\u1ee9c \u0103n ho\u1eb7c kh\u00f4ng c\u00f9ng th\u1ee9c \u0103n.<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p><em>\u0110i\u1ec1u tr\u1ecb ban \u0111\u1ea7u:<\/em><\/p>\n<p>Tr\u1ea7m c\u1ea3m v\u00e0 r\u1ed1i lo\u1ea1n c\u01b0\u1ee1ng b\u1ee9c \u00e1m \u1ea3nh: li\u1ec1u khuy\u1ebfn c\u00e1o l\u00e0 50 mg\/ng\u00e0y.<\/p>\n<p>R\u1ed1i lo\u1ea1n ho\u1ea3ng lo\u1ea1n v\u00e0 r\u1ed1i lo\u1ea1n stress sau ch\u1ea5n th\u01b0\u01a1ng: n\u00ean \u0111\u01b0\u1ee3c b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb v\u1edbi li\u1ec1u 25 mg\/ng\u00e0y. Sau m\u1ed9t tu\u1ea7n, li\u1ec1u tr\u00ean n\u00ean \u0111\u01b0\u1ee3c t\u0103ng l\u00ean \u0111\u1ebfn 50 mg, m\u1ed7i l\u1ea7n m\u1ed9t ng\u00e0y. Li\u1ec1u d\u00f9ng n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 gi\u1ea3m \u0111\u01b0\u1ee3c t\u1ea7n su\u1ea5t c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ea5p t\u00ednh khi kh\u1edfi \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb, l\u00e0 \u0111\u1eb7c tr\u01b0ng c\u1ee7a ch\u1ee9ng r\u1ed1i lo\u1ea1n ho\u1ea3ng s\u1ee3.<\/p>\n<p><em>Li\u1ec1u chu\u1ea9n:<\/em><\/p>\n<p>Tr\u1ea7m c\u1ea3m r\u1ed1i lo\u1ea1n xung l\u1ef1c c\u01b0\u1ee1ng b\u1ee9c \u00e1m \u1ea3nh, r\u1ed1i lo\u1ea1n ho\u1ea3ng s\u1ee3 v\u00e0 r\u1ed1i lo\u1ea1n c\u0103ng th\u1eb3ng sau ch\u1ea5n th\u01b0\u01a1ng.<\/p>\n<p>C\u00e1c b\u1ec7nh nh\u00e2n m\u00e0 kh\u00f4ng \u0111\u00e1p \u1ee9ng v\u1edbi li\u1ec1u 50 mg c\u00f3 th\u1ec3 thu \u0111\u01b0\u1ee3c k\u1ebft qu\u1ea3 t\u1ed1t khi t\u0103ng li\u1ec1u \u0111i\u1ec1u tr\u1ecb. S\u1ef1 thay \u0111\u1ed5i li\u1ec1u n\u00ean \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh v\u1edbi kho\u1ea3ng c\u00e1ch \u00edt nh\u1ea5t l\u00e0 1 tu\u1ea7n, c\u00f3 th\u1ec3 t\u0103ng l\u00ean m\u1ee9c t\u1ed1i \u0111a 200 mg\/ng\u00e0y.<\/p>\n<p>Sertraline c\u00f3 th\u1eddi gian b\u00e1n th\u1ea3i 24 gi\u1edd, m\u1ecdi s\u1ef1 thay \u0111\u1ed5i v\u1ec1 li\u1ec1u l\u01b0\u1ee3ng kh\u00f4ng n\u00ean ti\u1ebfn h\u00e0nh v\u1edbi kho\u1ea3ng c\u00e1ch \u00edt h\u01a1n m\u1ed9t tu\u1ea7n.<\/p>\n<p>T\u00e1c d\u1ee5ng kh\u1edfi \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y trong v\u00f2ng 7 ng\u00e0y. Tuy nhi\u00ean, th\u00f4ng th\u01b0\u1eddng c\u1ea7n thi\u1ebft c\u00f3 kho\u1ea3ng th\u1eddi gian d\u00e0i h\u01a1n \u0111\u1ec3 c\u00f3 th\u1ec3 \u0111\u00e1p \u1ee9ng \u0111i\u1ec1u tr\u1ecb r\u00f5 r\u00e0ng, \u0111\u1eb7c bi\u1ec7t trong ch\u1ee9ng r\u1ed1i lo\u1ea1n xung l\u1ef1c c\u01b0\u1ee1ng b\u1ee9c \u00e1m \u1ea3nh.<\/p>\n<p><em>\u0110i\u1ec1u tr\u1ecb duy tr\u00ec:<\/em><\/p>\n<p>Li\u1ec1u d\u00f9ng trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb d\u00e0i h\u1ea1n n\u00ean \u0111\u01b0\u1ee3c gi\u1eef \u1edf m\u1ee9c th\u1ea5p nh\u1ea5t m\u00e0 c\u00f3 hi\u1ec7u qu\u1ea3, sau \u0111\u00f3 \u0111i\u1ec1u ch\u1ec9nh t\u00f9y theo m\u1ee9c \u0111\u1ed9 \u0111\u00e1p \u1ee9ng \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p><em>S\u1eed d\u1ee5ng \u1edf tr\u1ebb em:<\/em><\/p>\n<p>\u0110\u1ed9 an to\u00e0n v\u00e0 hi\u1ec3u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb \u1edf tr\u1ebb em \u0111\u00e3 \u0111\u01b0\u1ee3c thi\u1ebfp l\u1eadp \u1edf c\u00e1c b\u1ec7nh nh\u00e2n nhi khoa b\u1ecb ch\u1ee9ng r\u1ed1i lo\u1ea1n c\u01b0\u1ee1ng b\u1ee9c \u00e1m \u1ea3nh tu\u1ed5i t\u1eeb 6 \u0111\u1ebfn 17 tu\u1ed5i.<\/p>\n<p>B\u1ec7nh nh\u00e2n tu\u1ed5i t\u1eeb 6-12 tu\u1ed5i: n\u00ean d\u00f9ng li\u1ec1u kh\u1edfi \u0111\u1ea7u 25 mg\/ng\u00e0y, t\u0103ng l\u00ean 50 mg\/ng\u00e0y sau 1 tu\u1ea7n \u0111i\u1ec1u tr\u1ecb. C\u00e1c li\u1ec1u ti\u1ebfp theo c\u00f3 th\u1ec3 t\u0103ng l\u00ean, trong tr\u01b0\u1eddng h\u1ee3p thi\u1ebfu \u0111\u00e1p \u1ee9ng v\u1edbi li\u1ec1u 50mg\/ng\u00e0y, \u0111\u1ebfn 200 mg\/ng\u00e0y n\u1ebfu c\u1ea7n.<\/p>\n<p>B\u1ec7nh nh\u00e2n tu\u1ed5i t\u1eeb 13 \u0111\u1ebfn 17: N\u00ean \u0111\u01b0\u1ee3c b\u1eaft \u0111\u1ea7u v\u1edbi li\u1ec1u 50 mg\/ng\u00e0y.<\/p>\n<p>N\u00ean \u0111\u01b0\u1ee3c xem x\u00e9t tr\u01b0\u1edbc khi t\u0103ng li\u1ec1u v\u01b0\u1ee3t qu\u00e1 50 mg\/ng\u00e0y.<\/p>\n<p><em>S\u1eed d\u1ee5ng \u1edf ng\u01b0\u1eddi cao tu\u1ed5i<\/em>: C\u00f3 th\u1ec3 s\u1ef1 d\u1ee5ng li\u1ec1u t\u01b0\u01a1ng t\u1ef1 nh\u01b0 c\u00e1c b\u1ec7nh nh\u00e2n tr\u1ebb.<\/p>\n<p><em>B\u1ec7nh nh\u00e2n suy gan<\/em>: Sertraline \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a ph\u00e2n l\u1edbn t\u1ea1i gan. N\u00ean kh\u1edfi \u0111\u1ea7u th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng sertraline \u1edf c\u00e1c b\u1ec7nh nh\u00e2n b\u1ecb b\u1ec7nh gan. N\u00ean s\u1eed d\u1ee5ng li\u1ec1u th\u1ea5p h\u01a1n ho\u1eb7c t\u0103ng kho\u1ea3ng c\u00e1ch gi\u1eefa c\u00e1c li\u1ec1u \u1edf c\u00e1c b\u1ec7nh nh\u00e2n suy gan.<\/p>\n<p><em>B\u1ec7nh nh\u00e2n suy th\u1eadn<\/em>: Ph\u1ea7n l\u1edbn sertraline b\u1ecb chuy\u1ec3n h\u00f3a trong c\u01a1 th\u1ec3, ch\u1ec9 m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf \u1edf d\u1ea1ng ch\u01b0a bi\u1ebfn \u0111\u1ed5i \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb qua n\u01b0\u1edbc ti\u1ec3u n\u00ean kh\u00f4ng b\u1eaft bu\u1ed9c ph\u1ea3i \u0111i\u1ec1u chinh li\u1ec1u d\u00f9ng theo c\u00e1c m\u1ee9c \u0111\u1ed9 suy th\u1eadn.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"43-chong-chi-dinh\"><\/span>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>B\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed qu\u00e1 m\u1eabn c\u1ea3m v\u1edbi sertraline<\/p>\n<p>Kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi sertraline tr\u00ean c\u00e1c b\u1ec7nh nh\u00e2n \u0111ang \u0111i\u1ec1u tr\u1ecb v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf men monoamine oxidase (IMAO).<br \/>\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" crossorigin=\"anonymous\"><\/script> <ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins> <script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h2><span class=\"ez-toc-section\" id=\"44-than-trong\"><\/span>4.4 Th\u1eadn tr\u1ecdng:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>C\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf men Monoamine oxidase (IMAO): c\u00e1c tr\u01b0\u1eddng h\u1ee3p c\u00f3 ph\u1ea3n \u1ee9ng nghi\u00eam tr\u1ecdng \u0111\u00f4i khi d\u1eabn \u0111\u1ebfn t\u1eed vong \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o \u1edf c\u00e1c b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng sertraline ph\u1ed1i h\u1ee3p v\u1edbi IMAO. Kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed1i h\u1ee3p c\u00f9ng IMAO ho\u1eb7c trong v\u00f2ng 14 ng\u00e0y sau khi ng\u1eebng \u0111i\u1ec1u tr\u1ecb v\u1edbi c\u00e1c thu\u1ed1c n\u00e0y. T\u01b0\u01a1ng t\u1ef1, ph\u1ea3i d\u1eebng \u0111i\u1ec1u tr\u1ecb v\u1edbi sertraline t\u1ed1i thi\u1ec3u 14 ng\u00e0y tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb v\u1edbi c\u00e1c thu\u1ed1c IMAO.<\/p>\n<p>C\u00e1c thu\u1ed1c g\u00e2y c\u01b0\u1eddng h\u1ec7 serotonergic kh\u00e1c: g\u00e2y t\u0103ng c\u01b0\u1eddng t\u00e1c d\u1ee5ng d\u1eabn truy\u1ec1n th\u1ea7n kinh tr\u00ean h\u1ec7 serotonergic, n\u00ean \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh c\u1ea9n th\u1eadn v\u00e0 n\u00ean tr\u00e1nh b\u1ea5t c\u1ee9 khi n\u00e0o c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c do nguy c\u01a1 t\u01b0\u01a1ng t\u00e1c v\u1ec1 d\u01b0\u1ee3c l\u00fd h\u1ecdc.<\/p>\n<p>Chuy\u1ec3n \u0111\u1ed5i gi\u1eefa c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc s\u1ef1 thu h\u1ed3i serotonin (SSRIs), c\u00e1c thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m ho\u1eb7c c\u00e1c thu\u1ed1c ch\u1ed1ng \u00e1m \u1ea3nh: n\u00ean theo d\u00f5i v\u00e0 c\u00f3 c\u00e1c \u0111\u00e1nh gi\u00e1 th\u1eadn tr\u1ecdng khi chuy\u1ec3n \u0111\u1ed5i, \u0111\u1eb7c bi\u1ec7t l\u00e0 t\u1eeb c\u00e1c thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i nh\u01b0 fluoxetine. Kho\u1ea3ng th\u1eddi gian c\u1ea7n thi\u1ebft \u0111\u1ec3 l\u00e0m s\u1ea1ch thu\u1ed1c ra kh\u1ecfi c\u01a1 th\u1ec3 tr\u01b0\u1edbc khi chuy\u1ec3n \u0111\u1ed5i t\u1eeb m\u1ed9t thu\u1ed1c \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc s\u1ef1 thu h\u1ed3i serotonin sang m\u1ed9t thu\u1ed1c kh\u00e1c v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp.<\/p>\n<p>T\u0103ng h\u01b0ng c\u1ea3m\/gi\u1ea3m h\u01b0ng c\u1ea3m: T\u0103ng h\u01b0ng c\u1ea3m\/gi\u1ea3m h\u01b0ng c\u1ea3m c\u0169ng \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o \u1edf m\u1ed9t t\u1ef7 l\u1ec7 nh\u1ecf b\u1ec7nh nh\u00e2n b\u1ecb r\u1ed1i lo\u1ea1n t\u00ecnh c\u1ea3m n\u1eb7ng, \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng c\u00e1c thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m v\u00e0 c\u00e1c thu\u1ed1c ch\u1ed1ng \u00e1m \u1ea3nh kh\u00e1c tr\u00ean th\u1ecb tr\u01b0\u1eddng.<\/p>\n<p>C\u01a1n \u0111\u1ed9ng kinh: C\u00e1c c\u01a1n \u0111\u1ed9ng kinh l\u00e0 nguy c\u01a1 ti\u1ec1m t\u00e0ng v\u1edbi vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c ch\u1ed1ng \u00e1m \u1ea3nh. Tuy nhi\u00ean do sertraline ch\u01b0a \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 \u1edf c\u00e1c b\u1ec7nh nh\u00e2n b\u1ecb ch\u1ee9ng r\u1ed1i lo\u1ea1n c\u01a1n \u0111\u1ed9ng kinh n\u00ean tr\u00e1nh s\u1eed d\u1ee5ng n\u00f3 cho c\u00e1c b\u1ec7nh nh\u00e2n b\u1ecb \u0111\u1ed9ng kinh kh\u00f4ng \u1ed5n \u0111\u1ecbnh \u0111\u00e3 \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t n\u00ean theo d\u00f5i c\u1ea9n th\u1eadn. N\u00ean ng\u1eebng s\u1eed d\u1ee5ng sertraline \u1edf b\u1ea5t k\u1ef3 b\u1ec7nh nh\u00e2n n\u00e0o c\u00f3 ph\u00e1t tri\u1ec3n c\u01a1n \u0111\u1ed9ng kinh.<\/p>\n<p>T\u1ef1 t\u1eed: Do kh\u1ea3 n\u0103ng b\u1ec7nh nh\u00e2n mu\u1ed1n t\u1ef1 t\u1eed g\u1eafn li\u1ec1n v\u1edbi c\u00e1c b\u1ec7nh nh\u00e2n tr\u1ea7m c\u1ea3m v\u00e0 c\u00f3 th\u1ec3 t\u1ed3n t\u1ea1i cho \u0111\u1ebfn khi c\u00f3 \u0111\u01b0\u1ee3c s\u1ef1 thuy\u00ean gi\u1ea3m \u0111\u00e1ng k\u1ec3, n\u00ean c\u1ea7n gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd c\u00e1c b\u1ec7nh nh\u00e2n trong giai \u0111o\u1ea1n kh\u1edfi \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb..<\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>Thu\u1ed1c kh\u00f4ng c\u00f3 \u1ea3nh h\u01b0\u1edfng tr\u00ean kh\u1ea3 n\u0103ng ho\u1ea1t \u0111\u1ed9ng t\u00e2m th\u1ea7n. V\u00ec c\u00e1c thu\u1ed1c h\u01b0\u1edbng th\u1ea7n n\u00f3i chung c\u00f3 th\u1ec3 l\u00e0m suy gi\u1ea3m kh\u1ea3 n\u0103ng l\u00e0m vi\u1ec7c v\u1ec1 tr\u00ed tu\u1ec7 hay c\u01a1 b\u1eafp c\u1ea7n thi\u1ebft cho nh\u1eefng c\u00f4ng vi\u1ec7c c\u00f3 nguy c\u01a1 ti\u1ec1m \u1ea9n cao nh\u01b0 l\u00e1i xe hay v\u1eadn h\u00e0nh m\u00e1y m\u00f3c. B\u1ec7nh nh\u00e2n n\u00ean th\u1eadn tr\u1ecdng.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"45-su-dung-cho-phu-nu-co-thai-va-cho-con-bu\"><\/span>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: C<\/p>\n<p>US FDA pregnancy category: NA<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>Sertraline \u0111\u01b0\u1ee3c ghi nh\u1eadn c\u00f3 li\u00ean quan \u0111\u1ebfn vi\u1ec7c ch\u1eadm h\u00ecnh th\u00e0nh x\u01b0\u01a1ng \u1edf ph\u00f4i thai. Ch\u1ec9 n\u00ean s\u1eed d\u1ee5ng thu\u1ed1c cho ph\u1ee5 n\u1eef c\u00f3 thai khi nh\u1eefng l\u1ee3i \u00edch m\u00e0 n\u00f3 mang l\u1ea1i l\u1edbn h\u01a1n nh\u1eefng r\u1ee7i ro c\u00f3 th\u1ec3 c\u00f3.<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>C\u00f3 r\u1ea5t \u00edt d\u1eef li\u1ec7u li\u00ean quan \u0111\u1ebfn n\u1ed3ng \u0111\u1ed9 c\u1ee7a sertraline trong s\u1eefa. Kh\u00f4ng c\u00f3 khuy\u1ebfn c\u00e1o d\u00f9ng thu\u1ed1c cho b\u00e0 m\u1eb9 cho con b\u00fa tr\u1eeb khi c\u00f3 s\u1ef1 \u0111\u00e1nh gi\u00e1 k\u1ef9 c\u00e0ng c\u1ee7a b\u00e1c s\u1ef9 r\u1eb1ng l\u1ee3i \u00edch \u0111i\u1ec1u tr\u1ecb mang l\u1ea1i l\u1edbn h\u01a1n nh\u1eefng r\u1ee7i ro c\u00f3 th\u1ec3 c\u00f3.<\/p>\n<p>C\u00e1c ph\u1ee5 n\u1eef c\u00f3 nguy c\u01a1 c\u00f3 thai n\u00ean s\u1eed d\u1ee5ng c\u00e1c bi\u1ec7n ph\u00e1p tr\u00e1nh thai \u0111\u1ea7y \u0111\u1ee7 khi s\u1eed d\u1ee5ng sertraline.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"46-tac-dung-khong-mong-muon-adr\"><\/span>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>H\u1ec7 th\u1ea7n kinh th\u1ef1c v\u1eadt: Gi\u00e3n \u0111\u1ed3ng t\u1eed, c\u01b0\u01a1ng \u0111au d\u01b0\u01a1ng v\u1eadt.<\/p>\n<p>To\u00e0n th\u00e2n: Ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, d\u1ecb \u1ee9ng, suy nh\u01b0\u1ee3c, m\u1ec7t m\u1ecfi, s\u1ed1t v\u00e0 b\u1eebng m\u1eb7t.<\/p>\n<p>H\u1ec7 tim m\u1ea1ch: \u0110au ng\u1ef1c, t\u0103ng huy\u1ebft \u00e1p, \u0111\u00e1nh tr\u1ed1ng ng\u1ef1c, ph\u00f9 quanh h\u1ed1c m\u1eaft, ng\u1ea5t v\u00e0 tim nhanh.<\/p>\n<p>H\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng v\u00e0 ngo\u1ea1i vi: H\u00f4n m\u00ea, co gi\u1eadt, \u0111au \u0111\u1ea7u, \u0111au n\u1eeda \u0111\u1ea7u, r\u1ed1i lo\u1ea1n v\u1eadn \u0111\u1ed9ng (bao g\u1ed3m c\u00e1c tri\u1ec7u ch\u1ee9ng ngo\u1ea1i th\u00e1p nh\u01b0 t\u0103ng v\u1eadn \u0111\u1ed9ng, t\u0103ng tr\u01b0\u01a1ng l\u1ef1c c\u01a1, nghi\u1ebfn r\u0103ng hay d\u00e1ng \u0111i b\u1ea5t th\u01b0\u1eddng) d\u1ecb c\u1ea3m v\u00e0 gi\u1ea3m c\u1ea3m gi\u00e1c.<\/p>\n<p>C\u00e1c d\u1ea5u hi\u1ec7u v\u00e0 tri\u1ec7u ch\u1ee9ng c\u00f3 li\u00ean quan \u0111\u1ebfn h\u1ed9i ch\u1ee9ng ng\u1ed9 \u0111\u1ed9c serotonin c\u0169ng \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o \u1edf m\u1ed9t v\u00e0i tr\u01b0\u1eddng h\u1ee3p s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c c\u01b0\u1eddng h\u1ec7 serotonergic, bao g\u1ed3m k\u00edch \u0111\u1ed9ng, l\u00fa l\u1eabn, to\u00e1t m\u1ed3 h\u00f4i, \u1ec9a ch\u1ea3y, s\u1ed1t, t\u0103ng huy\u1ebft \u00e1p, co c\u1ee9ng v\u00e0 nh\u1ecbp tim nhanh<\/p>\n<p>H\u1ec7 n\u1ed9i ti\u1ebft: T\u0103ng ti\u1ebft s\u1eefa, t\u0103ng prolactin huy\u1ebft v\u00e0 c\u01b0\u1eddng gi\u00e1p tr\u1ea1ng.<\/p>\n<p>H\u1ec7 ti\u00eau h\u00f3a: \u0110au b\u1ee5ng, vi\u00eam t\u1ee5y, n\u00f4n.<\/p>\n<p>H\u1ec7 t\u1ea1o m\u00e1u: Thay \u0111\u1ed5i ch\u1ee9c n\u0103ng ti\u1ec3u c\u1ea7u, ch\u1ea3y m\u00e1u b\u1ea5t th\u01b0\u1eddng (ch\u1ea3y m\u00e1u cam, xu\u1ea5t huy\u1ebft ti\u00eau h\u00f3a, \u0111i ti\u1ec3u ra m\u00e1u)<\/p>\n<p>C\u00e1c thay \u0111\u1ed5i v\u1ec1 x\u00e9t nghi\u1ec7m sinh h\u00f3a<\/p>\n<p>H\u1ec7 gan m\u1eadt: c\u00e1c b\u1ec7nh gan n\u1eb7ng (bao g\u1ed3m vi\u00eam gan, v\u00e0ng da v\u00e0 suy gan), t\u0103ng kh\u00f4ng c\u00f3 tri\u1ec7u ch\u1ee9ng transaminase huy\u1ebft t\u01b0\u01a1ng (SGOT v\u00e0 SGPT).<\/p>\n<p>H\u1ec7 dinh d\u01b0\u1ee1ng v\u00e0 chuy\u1ec3n h\u00f3a: H\u1ea1 natri huy\u1ebft, t\u0103ng cholesterol huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<p>T\u00e2m th\u1ea7n: K\u00edch \u0111\u1ed9ng, ph\u1ea3n \u1ee9ng th\u00e1i qu\u00e1, lo l\u1eafng, c\u00e1c tri\u1ec7u ch\u1ee9ng u u\u1ea5t, \u1ea3o gi\u00e1c v\u00e0 lo\u1ea1n t\u00e2m th\u1ea7n.<\/p>\n<p>H\u1ec7 sinh s\u1ea3n: Kinh nguy\u1ec7t kh\u00f4ng \u0111\u1ec1u.<\/p>\n<p>H\u00f4 h\u1ea5p: Co th\u1eaft ph\u1ebf qu\u1ea3n.<\/p>\n<p>Da: R\u1ee5ng l\u00f4ng t\u00f3c, ph\u00f9 m\u1ea1ch v\u00e0 ban da (bao g\u1ed3m, hi\u1ebfm g\u1eb7p c\u00e1c tr\u01b0\u1eddng h\u1ee3p vi\u00eam da tr\u00f3c v\u1ea3y n\u1eb7ng)<\/p>\n<p>H\u1ec7 ti\u1ebft ni\u1ec7u: Ph\u00f9 m\u1eb7t, b\u00ed ti\u1ec3u<\/p>\n<p>C\u00e1c tri\u1ec7u ch\u1ee9ng kh\u00e1c: C\u00e1c tri\u1ec7u ch\u1ee9ng xu\u1ea5t hi\u1ec7n khi ng\u1eebng \u0111i\u1ec1u tr\u1ecb v\u1edbi sertraline \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o bao g\u1ed3m: k\u00edch \u0111\u1ed9ng, lo l\u1eafng, ch\u00f3ng m\u1eb7t, \u0111au \u0111\u1ea7u v\u00e0 d\u1ecb c\u1ea3m.<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><br \/>\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" crossorigin=\"anonymous\"><\/script> <ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins> <script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h2><span class=\"ez-toc-section\" id=\"47-huong-dan-cach-xu-tri-adr\"><\/span>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>C\u00e1c ADR th\u01b0\u1eddng th\u1ea5y trong tu\u1ea7n \u0111\u1ea7u ho\u1eb7c 2 tu\u1ea7n \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb. T\u1ef7 l\u1ec7 ADR t\u0103ng khi t\u0103ng li\u1ec1u.<\/p>\n<p>C\u00e1c nghi\u00ean c\u1ee9u ti\u1ec1n l\u00e2m s\u00e0ng kh\u00f4ng th\u1ea5y sertralin g\u00e2y quen thu\u1ed1c v\u00e0 h\u1ed9i ch\u1ee9ng cai thu\u1ed1c sau khi ng\u1eebng d\u00f9ng. Tuy nhi\u00ean, c\u00e1c tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng cho th\u1ea5y h\u1ed9i ch\u1ee9ng cai thu\u1ed1c c\u00f3 th\u1ec3 x\u1ea3y ra sau v\u00e0i ng\u00e0y ng\u1eebng thu\u1ed1c. Kho\u1ea3ng 15% s\u1ed1 ng\u01b0\u1eddi l\u1edbn ph\u1ea3i ng\u1eebng li\u1ec7u ph\u00e1p sertralin trong th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u00ec c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 v\u1ec1 t\u00e2m tr\u00ed nh\u01b0 bu\u1ed3n ng\u1ee7, m\u1ea5t ng\u1ee7, v\u1eadt v\u00e3, run; c\u00e1c tri\u1ec7u ch\u1ee9ng th\u1ea7n kinh kh\u00e1c nh\u01b0 ch\u00f3ng m\u1eb7t, \u0111au \u0111\u1ea7u; ti\u00eau h\u00f3a nh\u01b0 bu\u1ed3n n\u00f4n, \u1ec9a ch\u1ea3y, ch\u00e1n \u0103n, m\u1ec7t m\u1ecfi, ch\u1eadm xu\u1ea5t tinh.<\/p>\n<p>H\u1ed9i ch\u1ee9ng cai thu\u1ed1c (ch\u01b0a x\u00e1ch \u0111\u1ecbnh h\u1eb3n l\u00e0 do thu\u1ed1c) x\u1ea3y ra d\u01b0\u1edbi 0,5% \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o \u1edf ng\u01b0\u1eddi \u0111i\u1ec1u tr\u1ecb sertralin. C\u00e1c tri\u1ec7u ch\u1ee9ng th\u01b0\u1eddng g\u1eb7p l\u00e0 h\u1ed9i ch\u1ee9ng gi\u1ed1ng c\u00fam nh\u01b0: M\u1ec7t m\u1ecfi, kh\u00f3 ch\u1ecbu \u1edf d\u1ea1 d\u00e0y (bu\u1ed3n n\u00f4n), ch\u00f3ng m\u1eb7t, nh\u1ee9c \u0111\u1ea7u nh\u1eb9, run, lo \u00e2u, l\u1ea1nh, to\u00e1t m\u1ed3 h\u00f4i, r\u1ed1i lo\u1ea1n \u0111i\u1ec1u ph\u1ed1i. Ngo\u00e0i ra r\u1ed1i lo\u1ea1n tr\u00ed nh\u1edb, m\u1ea5t ng\u1ee7, d\u1ecb c\u1ea3m, nh\u1ee9c \u0111\u1ea7u, c\u1ea3m gi\u00e1c gi\u1ed1ng cho\u00e1ng, h\u1ed3i h\u1ed9p, k\u00edch \u0111\u1ed9ng ho\u1eb7c c\u00f4ng k\u00edch. C\u00e1c ph\u1ea3n \u1ee9ng lo\u1ea1i n\u00e0y th\u01b0\u1eddng t\u1ef1 gi\u1ea3m \u0111i ho\u1eb7c \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n sau m\u1ed9t v\u00e0i tu\u1ea7n. \u0110\u1ec3 tr\u00e1nh h\u1ed9i ch\u1ee9ng cai thu\u1ed1c, n\u00ean gi\u1ea3m d\u1ea7n li\u1ec1u c\u1ee7a sertralin tr\u01b0\u1edbc khi ng\u1eebng thu\u1ed1c.<\/p>\n<p>C\u0169ng gi\u1ed1ng c\u00e1c thu\u1ed1c t\u00e1c d\u1ee5ng tr\u00ean h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng kh\u00e1c, n\u00ean \u0111\u00e1nh gi\u00e1 c\u1ea5n th\u1eadn t\u00ecnh tr\u1ea1ng quen thu\u1ed1c \u1edf ng\u01b0\u1eddi b\u1ec7nh tr\u01b0\u1edbc khi d\u00f9ng sertralin. N\u1ebfu ng\u01b0\u1eddi b\u1ec7nh c\u00f3 ti\u1ec1n s\u1eed quen thu\u1ed1c v\u1edbi m\u1ed9t thu\u1ed1c n\u00e0o \u0111\u00f3 th\u00ec khi \u0111i\u1ec1u tr\u1ecb c\u1ea7n ph\u1ea3i gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd c\u00e1c d\u1ea5u hi\u1ec7u quen thu\u1ed1c.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"48-tuong-tac-voi-cac-thuoc-khac\"><\/span>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>Thu\u1ed1c \u1ee9c ch\u1ebf men monoamine oxidase (IMAO):<\/em>\u00a0kh\u00f4ng s\u1eed d\u1ee5ng ph\u1ed1i h\u1ee3p v\u1edbi disulfiram ho\u1eb7c s\u1eed d\u1ee5ng trong v\u00f2ng 14 ng\u00e0y sau khi d\u1eebng \u0111i\u1ec1u tr\u1ecb v\u1edbi disulfiram.<\/p>\n<p><em>C\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng v\u00e0 r\u01b0\u1ee3u<\/em>: kh\u00f4ng d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi sertraline.<\/p>\n<p><em>Lithium<\/em>: N\u00ean c\u00f3 c\u00e1c bi\u1ec7n ph\u00e1p theo d\u00f5i th\u00edch h\u1ee3p khi s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi sertraline v\u1edbi c\u00e1c thu\u1ed1c lithium, ch\u1ea5t n\u00e0y c\u00f3 th\u1ec3 c\u00f3 t\u00e1c d\u1ee5ng th\u00f4ng qua c\u01a1 ch\u1ebf ho\u1ea1t h\u00f3a h\u1ec7 serotonegic.<\/p>\n<p><em>Phenyltoin<\/em>: Ng\u01b0\u1eddi ta khuy\u1ebfn c\u00e1o n\u00ean theo d\u00f5i n\u1ed3ng \u0111\u1ed9 c\u1ee7a phenyltoin trong huy\u1ebft t\u01b0\u01a1ng khi kh\u1edfi \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb v\u1edbi sertraline v\u00e0 \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u c\u1ee7a phenyltoin cho ph\u00f9 h\u1ee3p.<\/p>\n<p><em>Sumatripta<\/em>n: C\u1ea7n c\u00f3 c\u00e1c bi\u1ec7n ph\u00e1p theo d\u00f5i b\u1ec7nh nh\u00e2n th\u00edch h\u1ee3p n\u1ebfu tr\u00ean l\u00e2m s\u00e0ng b\u1eaft bu\u1ed9c ph\u1ea3i \u0111i\u1ec1u tr\u1ecb ph\u1ed1i h\u1ee3p gi\u1eefa sertraline v\u00e0 sumatriptan.<\/p>\n<p><em>C\u00e1c thu\u1ed1c c\u00f3 g\u1eafn k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng<\/em>: Do sertraline g\u1eafn k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng n\u00ean c\u1ea7n ghi nh\u1edb c\u00f3 nguy c\u01a1 ti\u1ec1m \u1ea9n c\u1ee7a s\u1ef1 t\u01b0\u01a1ng t\u00e1c gi\u1eefa sertraline v\u00e0 c\u00e1c thu\u1ed1c g\u1eafn k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng kh\u00e1c.<\/p>\n<p><em>Warfarin<\/em>: D\u00f9ng \u0111\u1ed3ng th\u1eddi g\u00e2y t\u0103ng c\u00f3 \u00fd ngh\u0129a th\u1ed1ng k\u00ea v\u1ec1 th\u1eddi gian prothrombin, \u00fd ngh\u0129a l\u00e2m s\u00e0ng c\u1ee7a t\u00e1c d\u1ee5ng n\u00e0y v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c bi\u1ebft.<\/p>\n<p><em>C\u00f3 t\u01b0\u01a1ng t\u00e1c thu\u1ed1c kh\u00e1c:<\/em>\u00a0S\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi sertraline 200mg\/ng\u00e0y v\u1edbi diazepam hay tolbutamide g\u00e2y bi\u1ebfn \u0111\u1ed5i m\u1ed9t ch\u00fat nh\u01b0ng c\u00f3 \u00fd ngh\u0129a th\u1ed1ng k\u00ea v\u1ec1 v\u00e0i th\u00f4ng s\u1ed1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc. D\u00f9ng \u0111\u1ed3ng th\u1eddi sertraline v\u1edbi cimetidine g\u00e2y gi\u1ea3m \u0111\u00e1ng k\u1ec3 \u0111\u1ed9 thanh th\u1ea3i c\u1ee7a Sertraline. Kh\u00f4ng th\u1ea5y c\u00f3 t\u01b0\u01a1ng t\u00e1c gi\u1eefa sertraline li\u1ec1u 200mg h\u00e0ng ng\u00e0y v\u1edbi glibenclamide hay digoxin.<\/p>\n<p><em>\u0110i\u1ec1u tr\u1ecb s\u1ed1c \u0111i\u1ec7n (ETC<\/em>): Ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng thi\u1ebft l\u1eadp nguy c\u01a1 hay l\u1ee3i \u00edch c\u1ee7a vi\u1ec7c k\u1ebft h\u1ee3p s\u1ed1c \u0111i\u1ec7n v\u00e0 sertraline.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"49-qua-lieu-va-xu-tri\"><\/span>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>C\u00e1c tr\u01b0\u1eddng h\u1ee3p d\u00f9ng qu\u00e1 li\u1ec1u v\u1edbi li\u1ec1u \u0111\u01a1n \u0111\u1ed9c l\u00ean \u0111\u1ebfn 13,5 g \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o. C\u00e1c tr\u01b0\u1eddng h\u1ee3p t\u1eed vong c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o li\u00ean quan \u0111\u1ebfn qu\u00e1 li\u1ec1u c\u1ee7a sertraline, ch\u1ee7 y\u1ebfu l\u00e0 khi d\u00f9ng ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c v\u00e0 r\u01b0\u1ee3u. B\u1ea5t k\u1ef3 tr\u01b0\u1eddng h\u1ee3p qu\u00e1 li\u1ec1u n\u00e0o c\u0169ng \u0111\u1ec1u ph\u1ea3i \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb m\u1ed9t c\u00e1ch t\u00edch c\u1ef1c.<\/p>\n<p>C\u00e1c tri\u1ec7u ch\u1ee9ng qu\u00e1 li\u1ec1u: Ng\u1ee7 g\u00e0, r\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a (bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n), nh\u1ecbp tim nhanh, run r\u1ea9y, k\u00edch \u0111\u1ed9ng v\u00e0 cho\u00e1ng v\u00e1ng, \u00edt g\u1eb7p h\u01a1n l\u00e0 h\u00f4n m\u00ea.<\/p>\n<p>Kh\u00f4ng c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u, n\u00ean thi\u1ebft l\u1eadp v\u00e0 duy tr\u00ec m\u1ed9t \u0111\u01b0\u1eddng th\u1edf \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o cung c\u1ea5p \u0111\u1ee7 oxi v\u00e0 trao \u0111\u1ed5i kh\u00ed. [Pharmog]. Than ho\u1ea1t ph\u1ed1i h\u1ee3p v\u1edbi thu\u1ed1c t\u1ea9y c\u00f3 th\u1ec3 cho hi\u1ec7u qu\u1ea3 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng ho\u1eb7c hi\u1ec7u qu\u1ea3 h\u01a1n l\u00e0 vi\u1ec7c r\u1eeda d\u1ea1 d\u00e0y. Kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng c\u00e1c bi\u1ec7n ph\u00e1p g\u00e2y n\u00f4n. N\u00ean theo d\u00f5i c\u00e1c th\u00f4ng s\u1ed1 quan tr\u1ecdng c\u1ee7a s\u1ef1 s\u1ed1ng v\u00e0 tim song song v\u1edbi c\u00e1c bi\u1ec7n ph\u00e1p x\u1eed l\u00fd tri\u1ec7u ch\u1ee9ng chung v\u00e0 c\u00e1c bi\u1ec7n ph\u00e1p h\u1ed3i s\u1ee9c. Do th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 r\u1ed9ng c\u1ee7a sertraline trong c\u01a1 th\u1ec3, n\u00ean c\u00e1c bi\u1ec7n ph\u00e1p nh\u01b0 g\u00e2y l\u1ee3i ti\u1ec3u b\u1eaft bu\u1ed9c, th\u1ea9m ph\u00e2n, truy\u1ec1n m\u00e1u, thay m\u00e1u \u0111\u1ec1u kh\u00f4ng th\u1ec3 mang l\u1ea1i k\u1ebft qu\u1ea3.<br \/>\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" crossorigin=\"anonymous\"><\/script> <ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins> <script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h1><span class=\"ez-toc-section\" id=\"5-co-che-tac-dung-cua-thuoc\"><\/span>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"51-duoc-luc-hoc\"><\/span>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Sertraline l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf m\u1ea1nh v\u00e0 \u0111\u1eb7c hi\u1ec7u s\u1ef1 thu h\u1ed3i senotonin (5-HT) \u1edf \u0111\u1ea7u s\u1ee3i th\u1ea7n kinh.<\/p>\n<p>\u1ede c\u00e1c li\u1ec1u l\u00e2m s\u00e0ng, sertraline \u1ee9c ch\u1ebf s\u1ef1 thu h\u1ed3i serotonin v\u00e0o trong c\u00e1c ti\u1ec3u c\u1ea7u \u1edf ng\u01b0\u1eddi.<\/p>\n<p>Thu\u1ed1c kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng k\u00edch th\u00edch, an th\u1ea7n hay t\u00e1c d\u1ee5ng kh\u00e1ng cholinergic hay g\u00e2y \u0111\u1ed9c tr\u00ean tim \u1edf \u0111\u1ed9ng v\u1eadt.<\/p>\n<p>Nh\u1edd t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc s\u1ef1 thu h\u1ed3i 5-HT, sertraline kh\u00f4ng t\u0103ng c\u01b0\u1eddng ho\u1ea1t t\u00ednh c\u1ee7a h\u1ec7 catecholaminergic.<\/p>\n<p>Sertraline kh\u00f4ng c\u00f3 \u00e1i l\u1ef1c v\u1edbi c\u00e1c th\u1ee5 th\u1ec3 h\u1ec7 muscarinic (h\u1ec7 cholinergic), serotonergic, dopaminergic, adrenergic, histaminergic, GABA hay benzodiazepine.<\/p>\n<p>D\u00f9ng l\u00e2u d\u00e0i sertraline \u1edf c\u00e1c \u0111\u1ed9ng v\u1eadt c\u00f3 li\u00ean quan \u0111\u1ebfn vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3m c\u00e1c th\u1ee5 th\u1ec3 norepinephrine \u1edf n\u00e3o c\u0169ng nh\u01b0 th\u01b0\u1eddng g\u1eb7p ph\u1ea3i \u1edf c\u00e1c thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m v\u00e0 ch\u1ed5ng \u00e1m \u1ea3nh c\u00f3 hi\u1ec7u qu\u1ea3 l\u00e2m s\u00e0ng kh\u00e1c.<\/p>\n<p>Kh\u00f4ng gi\u1ed1ng nh\u01b0 c\u00e1c thu\u1ed1c ch\u1ed5ng tr\u1ea7m c\u1ea3m 3 v\u00f2ng, kh\u00f4ng th\u1ea5y c\u00f3 hi\u1ec7n t\u01b0\u1ee3ng t\u0103ng c\u00e2n, th\u1eadm ch\u00ed v\u00e0i b\u1ec7nh nh\u00e2n c\u00f2n gi\u1ea3m c\u00e2n khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng sertraline.<\/p>\n<p>Sertraline ch\u1ee9ng t\u1ecf l\u00e0 kh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y l\u1ea1m d\u1ee5ng thu\u1ed1c.<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>Sertralin l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf m\u1ea1nh v\u00e0 ch\u1ecdn l\u1ecdc s\u1ef1 t\u00e1i thu h\u1ed3i serotonin (5 HT) \u1edf \u0111\u1ea7u s\u1ee3i th\u1ea7n kinh. Tr\u00ean in vitro, \u0111i\u1ec1u n\u00e0y d\u1eabn \u0111\u1ebfn s\u1ef1 t\u0103ng c\u01b0\u1eddng t\u00e1c d\u1ee5ng c\u1ee7a 5-HT \u1edf \u0111\u1ed9ng v\u1eadt. N\u00f3 ch\u1ec9 c\u00f3 t\u00e1c d\u1ee5ng r\u1ea5t y\u1ebfu tr\u00ean vi\u1ec7c thu h\u1ed3i norepinephrin v\u00e0 dopamin \u1edf c\u00e1c \u0111\u1ea7u s\u1ee3i th\u1ea7n kinh. \u1ede c\u00e1c li\u1ec1u l\u00e2m s\u00e0ng, sertralin \u1ee9c ch\u1ebf s\u1ef1 thu h\u1ed3i sertonin v\u00e0o trong c\u00e1c ti\u1ec3u c\u1ea7u \u1edf ng\u01b0\u1eddi. N\u00f3 kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng k\u00edch th\u00edch an th\u1ea7n hay t\u00e1c d\u1ee5ng kh\u00e1ng cholinergic hay g\u00e2y \u0111\u1ed9c tr\u00ean tim \u1edf \u0111\u1ed9ng v\u1eadt. C\u00e1c nghi\u00ean c\u1ee9u c\u00f3 ki\u1ec3m ch\u1ee9ng \u1edf nh\u1eefng ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n b\u00ecnh th\u01b0\u1eddng cho th\u1ea5y sertalin kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng an th\u1ea7n v\u00e0 kh\u00f4ng l\u00e0m \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng ho\u1ea1t \u0111\u1ed9ng t\u00e2m th\u1ea7n. Nh\u1edd t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc s\u1ef1 thu h\u1ed3i 5-HT, sertralin kh\u00f4ng t\u0103ng c\u01b0\u1eddng ho\u1ea1t t\u00ednh c\u1ee7a h\u1ec7 catecholaminergic. Sertralin kh\u00f4ng c\u00f3 \u00e1i l\u1ef1c v\u1edbi c\u00e1c th\u1ee5 th\u1ec3 h\u1ec7 muscarinic (h\u1ec7 cholinergic), serotonergic, dopaminergic, histaminergic, GABA hay c\u00e1c th\u1ee5 th\u1ec3 benzodiazepin. D\u00f9ng l\u00e2u d\u00e0i sertralin \u1edf \u0111\u1ed9ng v\u1eadt c\u00f3 li\u00ean quan \u0111\u1ebfn vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh gi\u1ea3m c\u00e1c th\u1ee5 th\u1ec3 neropinephrin \u1edf n\u00e3o c\u0169ng nh\u01b0 th\u01b0\u1eddng g\u1eb7p ph\u1ea3i \u1edf c\u00e1c thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m v\u00e0 ch\u1ed1ng \u00e1m \u1ea3nh c\u00f3 hi\u1ec7u qu\u1ea3 l\u00e2m s\u00e0ng kh\u00e1c.<\/p>\n<p><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/p>\n<h2><span class=\"ez-toc-section\" id=\"52-duoc-dong-hoc\"><\/span>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>H\u1ea5p thu<\/em><\/p>\n<p>Sertraline c\u00f3 c\u00e1c \u0111\u1eb7c t\u00ednh d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc ph\u1ee5 thu\u1ed9c theo li\u1ec1u trong kho\u1ea3ng t\u1eeb 50-200 mg \u1edf ng\u01b0\u1eddi, sau khi u\u1ed1ng li\u1ec1u m\u1ed9t l\u1ea7n h\u00e0ng ng\u00e0y trong kho\u1ea3ng t\u1eeb 50-200 mg trong 14 ng\u00e0y n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng (Cmax) c\u1ee7a sertraline xu\u1ea5t hi\u1ec7n trong kho\u1ea3ng 4,5 \u0111\u1ebfn 8,4 gi\u1edd sau khi u\u1ed1ng. C\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt ch\u1ec9 ra r\u1eb1ng sertraline c\u00f3 th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 l\u1edbn.<\/p>\n<p>C\u00e1c \u0111\u1eb7c t\u00ednh v\u1ec1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a sertraline \u1edf c\u00e1c b\u1ec7nh nh\u00e2n nhi khoa b\u1ecb r\u1ed1i lo\u1ea1n c\u01b0\u1ee1ng b\u1ee9c \u00e1m \u1ea3nh \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 t\u01b0\u01a1ng t\u1ef1 ng\u01b0\u1eddi l\u1edbn (m\u1eb7c d\u00f9, c\u00e1c b\u1ec7nh nh\u00e2n nhi khoa s\u1eed d\u1ee5ng sertraline c\u00f3 hi\u1ec7u qu\u1ea3 h\u01a1n m\u1ed9t ch\u00fat). Tuy nhi\u00ean ng\u01b0\u1eddi ta khuy\u00ean n\u00ean h\u1ea1 th\u1ea5p li\u1ec1u \u1edf c\u00e1c b\u1ec7nh nh\u00e2n nhi khoa m\u00e0 c\u00f3 tr\u1ecdng l\u01b0\u1ee3ng c\u01a1 th\u1ec3 th\u1ea5p (\u0111\u1eb7c bi\u1ec7t nh\u1eefng b\u1ec7nh nhi t\u1eeb 6-12 tu\u1ed5i) \u0111\u1ec3 tr\u00e1nh n\u1ed3ng \u0111\u1ed9 qu\u00e1 cao trong huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<p><em>Chuy\u1ec3n h\u00f3a<\/em><\/p>\n<p>Sertraline b\u1ecb chuy\u1ec3n h\u00f3a ph\u1ea7n l\u1edbn trong pha \u0111\u1ea7u \u1edf gan. Ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh trong huy\u1ebft t\u01b0\u01a1ng l\u00e0 N-desmethylsertraline, m\u1ed9t ch\u1ea5t \u00edt ho\u1ea1t t\u00ednh h\u01a1n \u0111\u00e1ng k\u1ec3 (kho\u1ea3ng 20 l\u1ea7n) so v\u1edbi sertraline tr\u00ean in vitro, tuy nhi\u00ean ch\u01b0a c\u00f3 th\u1eed nghi\u1ec7m v\u1ec1 ho\u1ea1t t\u00ednh tr\u00ean m\u00f4 h\u00ecnh in vivo \u1edf c\u00e1c b\u1ec7nh nh\u00e2n b\u1ecb tr\u1ea7m c\u1ea3m.<\/p>\n<p><em>Th\u1ea3i tr\u1eeb<\/em><\/p>\n<p>Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a N-desmethylsertraline n\u1eb1m trong kho\u1ea3ng 62-104 gi\u1edd. Sertraline v\u00e0 N-desmethylsertraline \u0111\u1ec1u b\u1ecb chuy\u1ec3n h\u00f3a ph\u1ea7n l\u1edbn \u1edf trong c\u01a1 th\u1ec3 ng\u01b0\u1eddi v\u00e0 cho ra c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a \u0111\u01b0\u1ee3c \u0111\u00e0o th\u00e0i qua ph\u00e2n v\u00e0 qua n\u01b0\u1edbc ti\u1ec3u \u1edf d\u1ea1ng ch\u01b0a bi\u1ebfn \u0111\u1ed5i.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"53-giai-thich\"><\/span>5.3 Gi\u1ea3i th\u00edch:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"54-thay-the-thuoc\"><\/span>5.4 Thay th\u1ebf thu\u1ed1c :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><br \/>\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" crossorigin=\"anonymous\"><\/script> <ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins> <script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h1><span class=\"ez-toc-section\" id=\"6-phan-thong-tin-kem-theo-cua-thuoc\"><\/span>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"61-danh-muc-ta-duoc\"><\/span>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>T\u00e1 d\u01b0\u1ee3c: Magnesium Stearate, Colloidal Anhydrous Silica, Calcium hydrogen phosphate didydarate, Sodium Carboxy Methyl starch, Microcystallin Cellulose 102, Opadry II 85F28751 (Polyvinyl Alcohol), Titanium Dioxide (E171), Talc, Polyethylene Glycol 300.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"62-tuong-ky\"><\/span>6.2. T\u01b0\u01a1ng k\u1ef5 :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>D\u1ea1ng thu\u1ed1c dung d\u1ecbch d\u1ec5 b\u1ecb k\u1ebft t\u1ee7a khi h\u00f2a v\u1edbi n\u01b0\u1edbc.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"63-bao-quan\"><\/span>6.3. B\u1ea3o qu\u1ea3n:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>N\u01a1i kh\u00f4, tr\u00e1nh \u00e1nh s\u00e1ng, nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30\u00b0C.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"64-thong-tin-khac\"><\/span>6.4. Th\u00f4ng tin kh\u00e1c :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Kh\u00f4ng c\u00f3.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"65-tai-lieu-tham-khao\"><\/span>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n<p>Ho\u1eb7c HDSD Thu\u1ed1c.<\/p>\n<h1><span class=\"ez-toc-section\" id=\"7-nguoi-dang-tai-tac-gia\"><\/span>7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p>B\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c s\u01b0u t\u1ea7m ho\u1eb7c vi\u1ebft b\u1edfi: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-tac-gia-bac-sy-do-my-linh\/\">B\u00e1c s\u0129 nhi khoa &#8211; \u0110\u1ed7 M\u1ef9 Linh.<\/a><\/p>\n<p>Ki\u1ec3m duy\u1ec7t , hi\u1ec7u \u0111\u00ednh v\u00e0 \u0111\u0103ng t\u1ea3i: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-ve-pharmog-team\/\">PHARMOG TEAM<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Clealine l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Clealine (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;) 1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Sertraline Ph\u00e2n lo\u1ea1i: Thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m lo\u1ea1i [&hellip;]<\/p>\n","protected":false},"author":8612,"featured_media":35290,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[1386],"class_list":["post-35289","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-sertraline"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/35289","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/8612"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=35289"}],"version-history":[{"count":3,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/35289\/revisions"}],"predecessor-version":[{"id":35351,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/35289\/revisions\/35351"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/35290"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=35289"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=35289"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=35289"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}