{"id":33694,"date":"2021-06-04T16:28:16","date_gmt":"2021-06-04T09:28:16","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=33694"},"modified":"2025-01-07T23:00:35","modified_gmt":"2025-01-07T16:00:35","slug":"lercanidipine-toropi","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/","title":{"rendered":"Lercanidipine &#8211; Toropi"},"content":{"rendered":"<p><em>Thu\u1ed1c Toropi l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Toropi (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;)<\/em><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_81 ez-toc-wrap-left counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">N\u1ed9i dung ch\u00ednh<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#1-ten-hoat-chat-va-biet-duoc\" >1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#2-dang-bao-che-%e2%80%93-ham-luong\" >2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#3-video-by-pharmog\" >3. Video by Pharmog:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#4-ung-dung-lam-sang\" >4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng:<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#41-chi-dinh\" >4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#42-lieu-dung-%e2%80%93-cach-dung\" >4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#43-chong-chi-dinh\" >4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#44-than-trong\" >4.4 Th\u1eadn tr\u1ecdng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#45-su-dung-cho-phu-nu-co-thai-va-cho-con-bu\" >4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#46-tac-dung-khong-mong-muon-adr\" >4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#47-huong-dan-cach-xu-tri-adr\" >4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#48-tuong-tac-voi-cac-thuoc-khac\" >4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#49-qua-lieu-va-xu-tri\" >4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#5-co-che-tac-dung-cua-thuoc\" >5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#51-duoc-luc-hoc\" >5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#52-duoc-dong-hoc\" >5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#53-giai-thich\" >5.3 Gi\u1ea3i th\u00edch:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#54-thay-the-thuoc\" >5.4 Thay th\u1ebf thu\u1ed1c :<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#6-phan-thong-tin-kem-theo-cua-thuoc\" >6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#61-danh-muc-ta-duoc\" >6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#62-tuong-ky\" >6.2. T\u01b0\u01a1ng k\u1ef5 :<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#63-bao-quan\" >6.3. B\u1ea3o qu\u1ea3n:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#64-thong-tin-khac\" >6.4. Th\u00f4ng tin kh\u00e1c :<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#65-tai-lieu-tham-khao\" >6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/pharmog.com\/wp\/lercanidipine-toropi\/#7-nguoi-dang-tai-tac-gia\" >7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<\/a><\/li><\/ul><\/nav><\/div>\n\n<h1><span class=\"ez-toc-section\" id=\"1-ten-hoat-chat-va-biet-duoc\"><\/span>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <\/strong><a href=\"https:\/\/pharmog.com\/wp\/lercanidipine\/\"><strong>Lercanidipine<\/strong><\/a><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u1ed1c ch\u1eb9n k\u00eanh calci.<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): C08CA13<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em><\/strong> <a href=\"https:\/\/pharmog.com\/wp\/lercanidipine-zanedip\/\">Zanedip<\/a><\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c:<\/em><\/strong> Toropi<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: Torrent Pharmaceuticals Ltd.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h1><span class=\"ez-toc-section\" id=\"2-dang-bao-che-%e2%80%93-ham-luong\"><\/span>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>Vi\u00ean n\u00e9n bao phim: 10 mg, 20 mg.<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>TOROPI 10<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean n\u00e9n bao phim c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Lercanidipine<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>10 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"569\" height=\"455\" class=\"wp-image-33695\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/06\/word-image-125.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/06\/word-image-125.png 569w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/06\/word-image-125-300x240.png 300w\" sizes=\"auto, (max-width: 569px) 100vw, 569px\" \/><\/p>\n<h1><span class=\"ez-toc-section\" id=\"3-video-by-pharmog\"><\/span>3. Video by Pharmog:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe loading=\"lazy\" title=\"[Pharmog SS1 - T\u1eadp 11] - D\u01b0\u1ee3c l\u00fd v\u1ec1 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/F1Pl4DO5flA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<h1><span class=\"ez-toc-section\" id=\"4-ung-dung-lam-sang\"><\/span>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"41-chi-dinh\"><\/span>4.1. Ch\u1ec9 \u0111\u1ecbnh:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u0110i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p<\/p>\n<h2><span class=\"ez-toc-section\" id=\"42-lieu-dung-%e2%80%93-cach-dung\"><\/span>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p>Thu\u1ed1c d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng. D\u00f9ng theo ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p>Ng\u01b0\u1eddi l\u1edbn:<\/p>\n<p>Li\u1ec1u kh\u1edfi \u0111\u1ea7u l\u00e0 10 mg X 1 l\u1ea7n\/ 1 ng\u00e0y, \u00edt nh\u1ea5t 15 ph\u00fat tr\u01b0\u1edbc b\u1eefa \u0103n, n\u1ebfu c\u1ea7n thi\u1ebft th\u00ec t\u0103ng l\u00ean 20mg, 1 l\u1ea7n\/ 1 ng\u00e0y sau \u00edt nh\u1ea5t 2 tu\u1ea7n. Tr\u00ean m\u1ed9t v\u00e0i tr\u01b0\u1eddng h\u1ee3p khi d\u00f9ng m\u1ed9t thu\u1ed1c ch\u1ed1ng t\u0103ng huy\u1ebft \u00e1p nh\u01b0 thu\u1ed1c ch\u1eb9n beta, thu\u1ed1c l\u1ee3i ni\u1ec7u, thu\u1ed1c \u1ee9c ch\u1ebf enzym chuy\u1ec3n angiotensin m\u00e0 kh\u00f4ng \u0111\u1ea1t hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb th\u00ec c\u00f3 th\u1ec3 d\u00f9ng th\u00eam Lercanidipin v\u1edbi li\u1ec1u nh\u01b0 khi d\u00f9ng m\u1ed9t m\u00ecnh.<\/p>\n<p>Tr\u1ebb em, ng\u01b0\u1eddi cao tu\u1ed5i, ng\u01b0\u1eddi suy gan, suy th\u1eadn: xem ph\u1ea7n \u201ckhuy\u1ebfn c\u00e1o v\u00e0 th\u1eadn tr\u1ecdng\u201d.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"43-chong-chi-dinh\"><\/span>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>M\u1eabn c\u1ea3m v\u1edbi c\u00e1c thu\u1ed1c nh\u00f3m dihydropyridin ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p>H\u1eb9p \u0111\u1ed9ng m\u1ea1ch ch\u1ee7, \u0111au th\u1eaft ng\u1ef1c kh\u00f4ng \u1ed5n \u0111\u1ecbnh, suy tim kh\u00f4ng ki\u1ec3m so\u00e1t, trong v\u00f2ng 1 th\u00e1ng sau khi m\u1eafc nh\u1ed3i m\u00e1u c\u01a1 tim, r\u1ed1i lo\u1ea1n chuy\u1ec3n h\u00f3a porphyrin c\u1ea5p t\u00ednh.<\/p>\n<p>Suy gan n\u1eb7ng.<\/p>\n<p>Suy th\u1eadn n\u1eb7ng (GFR &lt; 30 ml\/ph\u00fat\/l,73m2)<\/p>\n<p>Kh\u00f4ng ph\u1ed1i h\u1ee3p Lercanidipin v\u1edbi cyclosporin.<\/p>\n<p>Ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"44-than-trong\"><\/span>4.4 Th\u1eadn tr\u1ecdng:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>B\u1ec7nh thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 c\u01a1 tim<\/em>: c\u00e1c thu\u1ed1c nh\u00f3m dihydropyridin t\u00e1c d\u1ee5ng ng\u1eafn c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 tim m\u1ea1ch cho b\u1ec7nh nh\u00e2n b\u1ecb b\u1ec7nh thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 c\u01a1 tim. M\u1eb7c d\u00f9 Lercanidipin t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i, nh\u01b0ng c\u0169ng c\u1ea7n ph\u1ea3i th\u1eadn tr\u1ecdng khi d\u00f9ng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y. Th\u1eadn tr\u1ecdng khi d\u00f9ng cho b\u1ec7nh nh\u00e2n c\u00f3 h\u1ed9i ch\u1ee9ng n\u00fat xoang. M\u1eb7c d\u00f9 nh\u1eefng nghi\u00ean c\u1ee9u huy\u1ebft \u0111\u1ed9ng c\u00f3 ki\u1ec3m so\u00e1t cho th\u1ea5y kh\u00f4ng g\u00e2y suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1ea5t, nh\u01b0ng c\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng th\u1ea5t tr\u00e1i. C\u00e1c thu\u1ed1c nh\u00f3m dihydropyridin hi\u1ebfm khi g\u00e2y \u0111au v\u00f9ng th\u01b0\u1ee3ng v\u1ecb ho\u1eb7c \u0111au th\u1eaft ng\u1ef1c. R\u1ea5t hi\u1ec3m khi g\u00e2y gia t\u0103ng t\u1ea7n su\u1ea5t, th\u1eddi gian v\u00e0 m\u1ee9c \u0111\u1ed9 tr\u1ea7m tr\u1ecdng c\u1ee7a b\u1ec7nh \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u00e3 t\u1eebng c\u00f3 c\u01a1n \u0111au th\u1eaft ng\u1ef1c. R\u1ea5t hi\u1ebfm g\u1eb7p nh\u1ed3i m\u00e1u c\u01a1 tim<\/p>\n<p><em>Suy tim sung huy\u1ebft:<\/em> th\u00f4ng th\u01b0\u1eddng, c\u1ea7n d\u00f9ng th\u1eadn tr\u1ecdng c\u00e1c thu\u1ed1c ch\u1eb9n calci v\u1edbi b\u1ec7nh nh\u00e2n suy tim. M\u1eb7c d\u00f9 c\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt v\u00e0 c\u00e1c \u0111\u00e1nh gi\u00e1 huy\u1ebft \u0111\u1ed9ng c\u1ea5p t\u00ednh \u1edf b\u1ec7nh nh\u00e2n c\u00f2n \u0111\u01b0\u1ee3c b\u1ea3o t\u1ed3n ch\u1ee9c n\u0103ng t\u00e2m th\u1ea5t tr\u00e1i kh\u00f4ng cho th\u1ea5y Lercanidipin g\u00e2y gi\u1ea3m co b\u00f3p c\u01a1 tim tr\u1ef1c ti\u1ebfp, \u0111\u1ed9 an to\u00e0n v\u1edbi b\u1ec7nh nh\u00e2n suy tim xung huy\u1ebft kh\u00f4ng \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp.<\/p>\n<p>V\u00ec v\u1eady, gi\u1ed1ng nh\u01b0 c\u00e1c thu\u1ed1c ch\u1eb9n calci kh\u00e1c, c\u1ea7n d\u00f9ng Lercanidipin th\u1eadn tr\u1ecdng v\u1edbi c\u00e1c tr\u01b0\u1eddng h\u1ee3p tr\u00ean.<\/p>\n<p>Lercanidipine kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng cho nh\u1eefng b\u1ec7nh nh\u00e2n suy gan hay suy th\u1eadn n\u1eb7ng (GFR&lt; 30ml\/ph\u00fat\/l,73 m2)<\/p>\n<p><em>Ng\u01b0\u1eddi suy th\u1eadn:<\/em> m\u1eb7c d\u00f9 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a Lercanidipin \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn nh\u1eb9 t\u1edbi v\u1eeba l\u00e0 t\u01b0\u01a1ng t\u1ef1 v\u1edbi ng\u01b0\u1eddi b\u00ecnh th\u01b0\u1eddng, c\u1ea7n theo d\u00f5i ch\u1eb7t khi d\u00f9ng thu\u1ed1c v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y. Li\u1ec1u 10 mg h\u00e0ng ng\u00e0y \u0111\u01b0\u1ee3c dung n\u1ea1p t\u1ed1t nh\u01b0ng c\u1ea7n th\u1eadn tr\u1ecdng khi t\u0103ng li\u1ec1u l\u00ean 20 mg h\u00e0ng ng\u00e0y.<\/p>\n<p><em>Ng\u01b0\u01a1i suy gan.<\/em> d\u01b0\u1ecdc \u0111\u1ecdng h\u1ecdc \u1edf ng\u01b0\u1eddi suy gan nh\u1eb9 kh\u00f4ng kh\u00e1c v\u1edbi ng\u01b0\u1eddi b\u00ecnh th\u01b0\u1eddng tuy nhi\u00ean kh\u00f4ng c\u00f3 nghi\u00ean c\u1ee9u c\u1ee5 th\u1ec3 tr\u00ean ng\u01b0\u1eddi suy gan trung b\u00ecnh v\u00e0 li\u1ec1u khuy\u1ebfn c\u00e1o ch\u01b0a \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp. V\u00ec v\u1eady c\u1ea7n d\u00f9ng Lercanidipin th\u1eadn tr\u1ecdng v\u1edbi nh\u00f3m b\u1ec7nh nh\u00e2n suy gan v\u00e0 gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd trong su\u1ed1t qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb. V\u00ec sinh kh\u1ea3 d\u1ee5ng v\u00e0 t\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p c\u00f3 th\u1ec3 t\u0103ng l\u00ean. Ch\u1ec9 d\u00f9ng cho b\u1ec7nh nh\u00e2n suy gan trung b\u00ecnh khi l\u1ee3i \u00edch mang l\u1ea1i nhi\u1ec1u h\u01a1n nguy c\u01a1. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh Lercanidipin v\u1edbi b\u1ec7nh nh\u00e2n suy gan n\u1eb7ng.<\/p>\n<p><em>Ng\u01b0\u1eddi cao tu\u1ed5i:<\/em> c\u1ea7n th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng m\u1eb7c d\u00f9 c\u00e1c nghi\u00ean c\u1ee9u d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc v\u00e0 l\u00e2m s\u00e0ng cho th\u1ea5y kh\u00f4ng c\u1ea7n hi\u1ec7u ch\u1ec9nh li\u1ec1u Lercanidipin v\u1edbi ng\u01b0\u1eddi cao tu\u1ed5i.<\/p>\n<p><em>Tr\u1ebb em:<\/em> kh\u00f4ng d\u00f9ng cho tr\u1ebb em d\u01b0\u1edbi 18 tu\u1ed5i do hi\u1ec7u l\u1ef1c v\u00e0 t\u00ednh an to\u00e0n cho tr\u1ebb em ch\u01b0a \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp<\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>C\u1ea7n th\u1eadn tr\u1ecdng v\u00ec thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y hoa m\u1eaft, m\u1ec7t m\u1ecfi, suy nh\u01b0\u1ee3c, hi\u1ebfm g\u1eb7p ng\u1ee7 g\u00e0.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h2><span class=\"ez-toc-section\" id=\"45-su-dung-cho-phu-nu-co-thai-va-cho-con-bu\"><\/span>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: C<\/p>\n<p>US FDA pregnancy category: NA<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>M\u1ee9c C: ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u c\u1ee5 th\u1ec3 khi d\u00f9ng Lercanidipin cho ph\u1ee5 n\u1eef mang thai. Nh\u01b0ng kh\u00f4ng \u0111\u01b0\u1ee3c d\u00f9ng c\u00e1c dihydropyridin cho ph\u1ee5 n\u1eef c\u00f3 thai do c\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y thu\u1ed1c g\u00e2y d\u1ecb t\u1eadt kh\u00f4ng h\u1ed3i ph\u1ee5c. Do v\u1eady kh\u00f4ng \u0111\u01b0\u1ee3c d\u00f9ng Lercanidipin cho ph\u1ee5 n\u1eef mang thai v\u00e0 ph\u1ee5 n\u1eef c\u00f3 th\u1ec3 mang thai tr\u1eeb khi \u0111\u00e3 c\u00f3 bi\u1ec7n ph\u00e1p tr\u00e1nh thai an to\u00e0n.<\/p>\n<p>Khi cho chu\u1ed9t mang thai u\u1ed1ng Lercanidipin \u1edf li\u1ec1u l\u1edbn h\u01a1n ho\u1eb7c b\u1eb1ng 2,5 mg\/kg\/ng\u00e0y tr\u01b0\u1edbc khi giao ph\u1ed1i ho\u1eb7c 12 mg\/kg\/ ng\u00e0y b\u1eaft \u0111\u1ea7u t\u1eeb \u0111\u1ea7u thai k\u1ef3 th\u1ea5y chu\u1ed9t sinh kh\u00f3 h\u01a1n, t\u0103ng nguy c\u01a1 thai ch\u1ebft l\u01b0u, l\u00e0m gi\u1ea3m s\u1ee9c s\u1ed1ng c\u1ee7a chu\u1ed9t non. Kh\u00f4ng th\u1ea5y \u1ea3nh h\u01b0\u1edfng l\u00ean kh\u1ea3 n\u0103ng sinh s\u1ea3n v\u00e0 s\u1ed1ng s\u00f3t c\u1ee7a chu\u1ed9t non khi d\u00f9ng li\u1ec1u 0,5mg\/kg\/ng\u00e0y tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u mang thai ho\u1eb7c li\u1ec1u 2,5mg\/kg\/ng\u00e0y v\u00e0o giai \u0111o\u1ea1n \u0111\u1ea7u c\u1ee7a thai k\u1ef3. D\u00f9ng li\u1ec1u 2,5 mg\/kg\/ ng\u00e0y trong su\u1ed1t thai k\u1ef3 c\u0169ng l\u00e0m t\u0103ng nguy c\u01a1 d\u1ecb t\u1eadt n\u1ed9i t\u1ea1ng thai nhi, d\u1ecb t\u1eadt x\u01b0\u01a1ng \u1edf t\u1ea5t c\u1ea3 c\u00e1c m\u1ee9c li\u1ec1u. Ch\u01b0a c\u00f3 m\u1ee9c li\u1ec1u n\u00e0o kh\u00f4ng g\u00e2y \u1ea3nh h\u01b0\u1edfng cho ph\u1ee5 n\u1eef mang thai.<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>Kh\u00f4ng c\u00f3 nghi\u00ean c\u1ee9u \u0111\u1ea7y \u0111\u1ee7 d\u00f9ng Lercanidipin cho ph\u1ee5 n\u1eef nu\u00f4i con b\u00fa. Thu\u1ed1c c\u00f3 th\u1ec3 b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9 do c\u00f3 t\u00ednh th\u00e2n d\u1ea7u cao. V\u00ec v\u1eady, kh\u00f4ng \u0111\u01b0\u1ee3c d\u00f9ng Lercanidipin cho ph\u1ee5 n\u1eef cho con b\u00fa<\/p>\n<h2><span class=\"ez-toc-section\" id=\"46-tac-dung-khong-mong-muon-adr\"><\/span>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Lercanidipin \u0111\u01b0\u1ee3c h\u1ea5p thu t\u1ed1t. Trong ch\u00edn nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng so s\u00e1nh v\u1edbi gi\u1ea3 d\u01b0\u1ee3c v\u1edbi th\u1eddi gian k\u00e9o d\u00e0i \u00edt nh\u1ea5t 4 tu\u1ea7n, 582 b\u1ec7nh nh\u00e2n d\u00f9ng Lercanidipin, 292 b\u1ec7nh nh\u00e2n d\u00f9ng gi\u1ea3 d\u01b0\u1ee3c. H\u1ea7u h\u1ebft c\u00e1c t\u00e1c d\u1ee5ng x\u1ea3y ra \u0111\u1ec1u li\u00ean quan t\u1edbi t\u00e1c d\u1ee5ng gi\u00e3n m\u1ea1ch c\u1ee7a Lercanidipin v\u00e0 ch\u1ee7 y\u1ebfu l\u00e0 nh\u1eb9 t\u1edbi v\u1eeba.<\/p>\n<p>B\u1ea3ng 1 sau \u0111\u00e2y li\u1ec7t k\u00ea c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n, li\u1ec7t k\u00ea theo c\u00e1c c\u01a1 quan, \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o khi d\u00f9ng Lercanidipin v\u00e0 gi\u1ea3 d\u01b0\u1ee3c cho b\u1ec7nh nh\u00e2n b\u1ecb t\u0103ng huy\u1ebft \u00e1p, trong \u0111\u00f3 c\u00e1c tr\u01b0\u1eddng h\u1ee3p x\u1ea3y ra \u0111\u1ec1u l\u1edbn h\u01a1n ho\u1eb7c b\u1eb1ng 1% \u1edf \u00edt nh\u1ea5t m\u1ed9t nh\u00f3m d\u00f9ng thu\u1ed1c. (Tham kh\u1ea3o b\u1ea3ng 1)<\/p>\n<p>B\u1ea3ng 1: C\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n v\u1edbi t\u1ea7n su\u1ed1t &gt;1% \u1edf \u00edt nh\u1ea5t m\u1ed9t nh\u00f3m d\u00f9ng thu\u1ed1c<\/p>\n<table>\n<tbody>\n<tr>\n<td>T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n<\/td>\n<td>Nh\u00f3m d\u00f9ng Lercanidipin li\u1ec1u 10 mg X 1 l\u1ea7n\/ ng\u00e0y (%)<\/td>\n<td>Nh\u00f3m d\u00f9ng Lercanidipin li\u1ec1u 20 mg X 1 l\u1ea7n\/ ng\u00e0y (\u0111\u00e3 hi\u1ec7u ch\u1ec9nh)<\/p>\n<p>(%)<\/td>\n<td>Nh\u00f3m d\u00f9ng gi\u1ea3 d\u01b0\u1ee3c<\/p>\n<p>(%)<\/td>\n<\/tr>\n<tr>\n<td>Tr\u00ean tim m\u1ea1ch:<\/p>\n<p>&#8211; \u0110\u1ecf b\u1eebng (da m\u1eb7t, ng\u1ef1c)<\/td>\n<td>2,6<\/td>\n<td>2,2<\/td>\n<td>1,6<\/td>\n<\/tr>\n<tr>\n<td>&#8211; \u0110\u00e1nh tr\u1ed1ng ng\u1ef1c\/ nh\u1ecbp nhanh<\/td>\n<td>1,5<\/td>\n<td>1,1<\/td>\n<td>0,3<\/td>\n<\/tr>\n<tr>\n<td>To\u00e0n th\u00e2n:<\/p>\n<p>&#8211; ph\u00f9 ngo\u1ea1i bi\u00ean<\/td>\n<td>1,0<\/td>\n<td>1,1<\/td>\n<td>0,9<\/td>\n<\/tr>\n<tr>\n<td>Th\u1ea7n kinh trung \u01b0\u01a1ng:<\/p>\n<p>&#8211; Hoa m\u1eaft ch\u00f3ng m\u1eb7t<\/td>\n<td>1,0<\/td>\n<td>0,0<\/td>\n<td>0,6<\/td>\n<\/tr>\n<tr>\n<td>&#8211; \u0110au \u0111\u1ea7u<\/td>\n<td>4,4<\/td>\n<td>4,3<\/td>\n<td>2,5<\/td>\n<\/tr>\n<tr>\n<td>Gan:<\/p>\n<p>&#8211; T\u0103ng GGT<\/td>\n<td>0,0<\/td>\n<td>1,1<\/td>\n<td>0,3<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Ngo\u00e0i ra, trong m\u1ed9t nghi\u00ean c\u1ee9u v\u1edbi 15500 b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Lercanidipin (bao g\u1ed3m c\u00e1c nghi\u00ean c\u1ee9u tr\u01b0\u1edbc k\u1ef3 kinh nguy\u1ec7t) v\u1edbi li\u1ec1u t\u1eeb 2,5 mg h\u00e0ng ng\u00e0y t\u1edbi li\u1ec1u 40 mg h\u00e0ng ng\u00e0y v\u00e0 th\u1eddi gian \u0111i\u1ec1u tr\u1ecb c\u00f3 th\u1ec3 l\u00e0 d\u00f9ng \u0111\u01a1n li\u1ec1u t\u1edbi k\u00e9o d\u00e0i h\u01a1n m\u1ed9t n\u0103m. C\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n kh\u00f4ng ch\u1eafc ch\u1eafn do thu\u1ed1c v\u00e0 x\u1ea3y ra d\u01b0\u1edbi 1% nh\u01b0ng l\u1edbn h\u01a1n ho\u1eb7c b\u1eb1ng 0,1% \u0111\u00e3 \u0111\u01b0\u1ee3c t\u1ed5ng h\u1ee3p v\u00e0 b\u00e1o c\u00e1o (theo c\u00e1c c\u01a1 quan c\u1ee7a c\u01a1 th\u1ec3).<\/p>\n<p>Tim m\u1ea1ch: \u0111\u00e1nh tr\u1ed1ng ng\u1ef1c\/ nh\u1ecbp nhanh.<\/p>\n<p>Th\u1ea7n kinh trung \u01b0\u01a1ng: hoa m\u1eaft, ch\u00f3ng m\u1eb7t.<\/p>\n<p>H\u1ec7 ti\u00eau h\u00f3a: bu\u1ed3n n\u00f4n, kh\u00f3 ti\u00eau, \u0111au b\u1ee5ng, ti\u00eau ch\u1ea3y.<\/p>\n<p>T\u00e2m th\u1ea7n: ng\u1ee7 g\u00e0<\/p>\n<p>To\u00e0n th\u00e2n: \u0111\u1ecf b\u1eebng m\u1eb7t, suy nh\u01b0\u1ee3c (m\u1ec7t m\u1ecfi v\u00e0 y\u1ebfu c\u01a1).<\/p>\n<p><em>Hi\u1ebfm g\u1eb7p c\u00e1c t\u00e1c d\u1ee5ng sau:<\/em><\/p>\n<p>Tim m\u1ea1ch: h\u1ea1 \u00e1p, h\u1ea1 \u00e1p t\u01b0 th\u1ebf \u0111\u1ee9ng, ph\u00f9 quanh h\u1ed1c m\u1eaft, \u0111au ng\u1ef1c, nh\u1ed3i m\u00e1u c\u01a1 tim, suy tim.<\/p>\n<p>H\u00f4 h\u1ea5p: kh\u00f3 th\u1edf.<\/p>\n<p>H\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng v\u00e0 ngo\u1ea1i bi\u00ean: \u0111au n\u1eeda \u0111\u1ea7u, d\u1ecb c\u1ea3m, t\u00ea ch\u00e2n.<\/p>\n<p>X\u00fac gi\u00e1c: thay \u0111\u1ed5i v\u1ecb gi\u00e1c.<\/p>\n<p>H\u1ec7 ti\u00eau h\u00f3a: n\u00f4n, r\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a kh\u00f4ng \u0111\u1eb7c tr\u01b0ng<\/p>\n<p>Gan v\u00e0 m\u1eadt: t\u0103ng GGT<\/p>\n<p>Ti\u1ebft ni\u1ec7u sinh d\u1ee5c: \u0111a ni\u1ec7u, ti\u1ec3u nhi\u1ec1u, b\u1ea5t l\u1ef1c.<\/p>\n<p>C\u01a1 x\u01b0\u01a1ng: \u0111au c\u01a1.<\/p>\n<p>Da v\u00e0 ph\u1ea7n ph\u1ee5: ban da, ng\u1ee9a, vi\u00eam da d\u1ecb \u1ee9ng, n\u1ed5i m\u1ec1 \u0111ay, t\u0103ng ti\u1ebft m\u1ed3 h\u00f4i.<\/p>\n<p>T\u00e2m th\u1ea7n: lo l\u1eafng, ng\u1ee7 g\u00e0.<\/p>\n<p>Chuy\u1ec3n h\u00f3a: t\u0103ng Cholesterol huy\u1ebft.<\/p>\n<p>To\u00e0n th\u00e2n: \u0111au ng\u1ef1c, kh\u00f3 ch\u1ecbu.<\/p>\n<p>C\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n n\u1eb7ng \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o d\u01b0\u1edbi 0,002% trong c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng. H\u1ea7u h\u1ebft c\u00e1c tr\u01b0\u1eddng h\u1ee3p x\u1ea3y ra \u0111\u1ec1u nh\u1eb9 t\u1edbi v\u1eeba.<\/p>\n<p>Th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng: kh\u00f4ng c\u00f3 b\u00e1o c\u00e1o t\u0103ng \u0111\u1ea3o ng\u01b0\u1ee3c n\u1ed3ng \u0111\u1ed9 transaminase gan. Kh\u00f4ng th\u1ea5y Lercanidipin g\u00e2y ra c\u00e1c k\u1ebft qu\u1ea3 x\u00e9t nghi\u1ec7m b\u1ea5t th\u01b0\u1eddng n\u00e0o. Lercanidipin kh\u00f4ng l\u00e0m \u1ea3nh h\u01b0\u1edfng t\u1edbi n\u1ed3ng \u0111\u1ed9 \u0111\u01b0\u1eddng huy\u1ebft ho\u1eb7c lipid huy\u1ebft<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<h2><span class=\"ez-toc-section\" id=\"47-huong-dan-cach-xu-tri-adr\"><\/span>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>C\u00e1c ADR th\u01b0\u1eddng xu\u1ea5t hi\u1ec7n l\u00fac b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb ho\u1eb7c khi t\u0103ng li\u1ec1u. \u0110a s\u1ed1 th\u01b0\u1eddng tho\u1ea3ng qua v\u00e0 h\u1ebft ngay khi ng\u1eebng thu\u1ed1c. N\u1ebfu th\u1ea5y c\u01a1n \u0111au th\u1eaft ng\u1ef1c l\u00fac \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb, c\u1ea7n ng\u1eebng thu\u1ed1c ngay.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"48-tuong-tac-voi-cac-thuoc-khac\"><\/span>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Lercanidipin an to\u00e0n khi d\u00f9ng c\u00f9ng c\u00e1c thu\u1ed1c l\u1ee3i ni\u1ec7u v\u00e0 c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf enzym chuy\u1ec3n angiotensin. Lercanidipin c\u0169ng c\u00f3 th\u1ec3 ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c ch\u1eb9n beta m\u00e0 \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb d\u01b0\u1edbi d\u1ea1ng kh\u00f4ng \u0111\u1ed5i (nh\u01b0 tremolo).<\/p>\n<p><em>V\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf ho\u1eb7c c\u1ea3m \u1ee9ng cytochrome CY3A4:<\/em><\/p>\n<p>V\u00ec con \u0111\u01b0\u1eddng chuy\u1ec3n h\u00f3a ch\u00ednh c\u1ee7a Lercanidipin th\u00f4ng qua enzym CYP3A4, c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf ho\u1eb7c c\u1ea3m \u1ee9ng enzym n\u00e0y c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng t\u1edbi n\u1ed3ng \u0111\u1ed9 trong m\u00e1u c\u1ee7a Lercanidipin.<\/p>\n<p>Do v\u1eady, c\u1ea7n th\u1eadn tr\u1ecdng khi ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf CYP3A4 (nh\u01b0 ketoconazol, itraconazol, erythromycin, ritonavir v\u00e0 fluoxetin) v\u00ec c\u00f3 th\u1ec3 g\u00e2y t\u0103ng n\u1ed3ng \u0111\u1ed9 c\u1ee7a Lercanidipin. Khi ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c c\u1ea3m \u1ee9ng CYP3A4 nh\u01b0 c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh (phenytoin, Carbamazepin), rifampicin, t\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p c\u1ee7a Lercanidipin b\u1ecb gi\u1ea3m \u0111i. V\u00ec v\u1eady c\u1ea7n theo d\u00f5i huy\u1ebft \u00e1p khi \u0111\u00e3 d\u00f9ng ph\u1ed1i h\u1ee3p Lercanidipin v\u1edbi c\u00e1c thu\u1ed1c n\u00e0y.<\/p>\n<p><em>C\u01a1 ch\u1ea5t CYP3A4 v\u00e0 CYP2D6<\/em>: \u1edf in vivo, t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf CYP3A4 c\u1ee7a Lercanidipin l\u00e0 kh\u00f4ng \u0111\u00e1ng k\u1ec3, \u0111i\u1ec1u n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh trong nghi\u00ean c\u1ee9u t\u01b0\u01a1ng t\u00e1c v\u1edbi midazolam \u1edf ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n kh\u1ecfe m\u1ea1nh. Sau khi d\u00f9ng ph\u1ed1i h\u1ee3p nh\u1eafc l\u1ea1i v\u1edbi Lercanidipin, midazolam (m\u1ed9t ch\u1ea5t th\u1eed c\u1ee7a CYP3A4 th\u1ec3 ho\u1ea1t \u0111\u1ed9ng) t\u01b0\u01a1ng \u0111\u01b0\u01a1ng sinh h\u1ecdc v\u1edbi khi d\u00f9ng m\u1ed9t m\u00ecnh. Tuy nhi\u00ean, c\u1ea7n th\u1eadn tr\u1ecdng khi ph\u1ed1i h\u1ee3p Lercanidipin v\u1edbi c\u00e1c c\u01a1 ch\u1ea5t c\u1ee7a CYP3A4 m\u00e0 c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb h\u1eb9p nh\u01b0 cyclosporin v\u00e0 thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp nh\u00f3m III (nh\u01b0 amiodaron v\u00e0 quinidin), tr\u1eeb phi c\u00f3 c\u00e1c d\u1eef li\u1ec7u \u0111\u1eb7c tr\u01b0ng kh\u00e1c.<\/p>\n<p>Ph\u1ed1i h\u1ee3p Lercanidipin v\u1edbi cyclosporin l\u00e0m t\u0103ng g\u1ea5p 3 l\u1ea7n n\u1ed3ng \u0111\u1ed9 trong m\u00e1u v\u00e0 t\u0103ng 21% sinh kh\u1ea3 d\u1ee5ng c\u1ee7a Lercanidipin. Tuy nhi\u00ean khi cyclosporin \u0111\u01b0\u1ee3c d\u00f9ng c\u00e1ch 3 gi\u1edd sau khi d\u00f9ng Lercanidipin th\u00ec sinh kh\u1ea3 d\u1ee5ng c\u1ee7a cyclosporin t\u0103ng 27%. V\u00ec v\u1eady, kh\u00f4ng \u0111\u01b0\u1ee3c ph\u1ed1i h\u1ee3p hai thu\u1ed1c n\u00e0y v\u1edbi nhau.<\/p>\n<p>H\u01a1n n\u1eefa c\u00e1c nghi\u00ean c\u1ee9u t\u01b0\u01a1ng t\u00e1c \u1edf ng\u01b0\u1eddi th\u1ea5y Lercanidipin kh\u00f4ng l\u00e0m thay \u0111\u1ed5i n\u1ed3ng \u0111\u1ed9 c\u1ee7a metoprolol, (m\u1ed9t c\u01a1 ch\u1ea5t \u0111i\u1ec3n h\u00ecnh c\u1ee7a CYP2D6). V\u00ec v\u1eady, \u1edf li\u1ec1u \u0111i\u1ec1u tr\u1ecb, Lercanidipin kh\u00f4ng \u1ee9c ch\u1ebf chuy\u1ec3n h\u00f3a c\u1ee7a c\u00e1c ch\u1ea5t \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1edfi CYP2D6.<\/p>\n<p>\u0110i\u1ec1u \u0111\u00f3 ch\u1ee9ng t\u1ecf \u1edf in vitro s\u1ef1 \u1ee9c ch\u1ebf c\u00e1c enzym isoenzym Cytochrom P450 c\u1ee7a Lercanidipin l\u00e0 kh\u00f4ng c\u00f3 \u00fd ngh\u0129a v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng. C\u00e1c nghi\u00ean c\u1ee9u in vitro v\u1edbi c\u00e1c vi l\u1ea1p th\u1ec3 gan ng\u01b0\u1eddi cho th\u1ea5y Lercanidipin \u1ee9c ch\u1ebf CYP3A4 v\u00e0 CYP2D6 (IC 50 l\u1ea7n l\u01b0\u1ecdt l\u00e0 2,6 v\u00e0 0,8 mcg). N\u1ed3ng \u0111\u1ed9 IC50 c\u1ee7a CYP3A4 v\u00e0 CYP2D6 cao h\u01a1n 160 v\u00e0 40 l\u1ea7n so v\u1edbi c\u00e1c n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh n\u00e0y sau khi d\u00f9ng li\u1ec1u 20 mg.<\/p>\n<p><em>V\u1edbi thu\u1ed1c ch\u1eb9n beta:<\/em> khi d\u00f9ng Lercanidipin v\u1edbi metoprolol, m\u1ed9t thu\u1ed1c ch\u1eb9n beta \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu qua th\u1eadn, sinh kh\u1ea3 d\u1ee5ng c\u1ee7a metoprolol kh\u00f4ng b\u1ecb thay \u0111\u1ed5i, trong khi sinh kh\u1ea3 d\u1ee5ng c\u1ee7a Lercanidipin b\u1ecb gi\u1ea3m 50%. V\u00ec v\u1eady, c\u1ea7n t\u0103ng li\u1ec1u Lercanidipin khi ph\u1ed1i h\u1ee3p v\u1edbi metoprolol. T\u00e1c d\u1ee5ng n\u00e0y c\u0169ng c\u00f3 th\u1ec3 x\u1ea3y ra t\u01b0\u01a1ng t\u1ef1 khi d\u00f9ng Lercanidipin c\u00f9ng propanolol.<\/p>\n<p><em>V\u1edbi glycosid tim:<\/em> ph\u1ed1i h\u1ee3p Lercanidipin v\u1edbi b\u1ec7nh nh\u00e2n d\u00f9ng k\u00e9o d\u00e0i c\u00e1c beta-methyldigoxin (ti\u1ec1n ch\u1ea5t c\u1ee7a digoxin) kh\u00f4ng th\u1ea5y t\u01b0\u01a1ng t\u00e1c d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc n\u00e0o x\u1ea3y ra. Tuy nhi\u00ean, c\u1ea7n theo d\u00f5i ch\u1eb7t b\u1ec7nh nh\u00e2n khi ph\u1ed1i h\u1ee3p Lercanidipin v\u1edbi c\u00e1c glycosid tim.<\/p>\n<p><em>V\u1edbi Cimetidin:<\/em> d\u00f9ng li\u1ec1u cimetidin 400 mg X 2 l\u1ea7n\/ ng\u00e0y kh\u00f4ng \u1ea3nh h\u01b0\u1edfng t\u1edbi n\u1ed3ng \u0111\u1ed9 c\u1ee7a Lercanidipin. AUC v\u00e0 Cmax t\u0103ng trung b\u00ecnh 11%. Tuy nhi\u00ean sinh kh\u1ea3 d\u1ee5ng v\u00e0 t\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p c\u1ee7a Lercanidipin c\u00f3 th\u1ec3 t\u0103ng l\u00ean khi d\u00f9ng li\u1ec1u cao h\u01a1n.<\/p>\n<p><em>V\u1edbi simvastatin:<\/em> ph\u1ed1i h\u1ee3p Lercanidipin 20 mg v\u1edbi simvastatin 40 mg kh\u00f4ng l\u00e0m t\u0103ng sinh kh\u1ea3 d\u1ee5ng c\u1ee7a Lercanidipin. Tuy nhi\u00ean ph\u1ed1i h\u1ee3p n\u00e0y c\u00f3 th\u1ec3 l\u00e0m sinh kh\u1ea3 d\u1ee5ng c\u1ee7a simvastatin t\u0103ng 56% v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh beta-hydroxyacid c\u1ee7a n\u00f3 t\u0103ng 28%. S\u1ef1 thay \u0111\u1ed5i n\u00e0y kh\u00f4ng th\u1ef1c s\u1ef1 c\u1ecf \u00fd ngh\u0129a l\u00e2m s\u00e0ng. Tuy nhi\u00ean, t\u1ed1t nh\u1ea5t n\u00ean d\u00f9ng Lercanidipin v\u00e0o bu\u1ed5i s\u00e1ng v\u00e0 simvastatin v\u00e0o bu\u1ed5i t\u1ed1i.<\/p>\n<p><em>V\u1edbi th\u1ee9c \u0103n<\/em>: (xem ph\u1ea7n d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc) s\u1ef1 chuy\u1ec3n h\u00f3a c\u1ee7a dihydropyridin c\u00f3 th\u1ec3 b\u1ecb \u1ee9c ch\u1ebf do n\u01b0\u1edbc \u00e9p b\u01b0\u1edfi, d\u1eabn \u0111\u1ebfn l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ecd v\u00e0 t\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p. Tr\u00e1nh u\u1ed1ng r\u01b0\u1ee3u khi d\u00f9ng Lercanidipin v\u00ec c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c h\u1ea1 huy\u1ebft \u00e1p g\u00e2y gi\u00e3n m\u1ea1ch.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h2><span class=\"ez-toc-section\" id=\"49-qua-lieu-va-xu-tri\"><\/span>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>Tri\u1ec7u ch\u1ee9ng:<\/em> c\u00f3 \u00edt b\u00e1o c\u00e1o qu\u00e1 li\u1ec1u khi d\u00f9ng Lercanidipin. Gi\u1ed1ng nh\u01b0 c\u00e1c dihydropyridin kh\u00e1c, tri\u1ec7u ch\u1ee9ng khi qu\u00e1 li\u1ec1u c\u00f3 th\u1ec3 l\u00e0 gi\u00e3n m\u1ea1ch ngo\u1ea1i bi\u00ean qu\u00e1 m\u1ee9c d\u1eabn t\u1edbi h\u1ea1 huy\u1ebft \u00e1p \u0111\u00e1ng k\u1ec3 v\u00e0 g\u00e2y ph\u1ea3n x\u1ea1 nh\u1ecbp nhanh.<\/p>\n<p><em>X\u1eed tr\u00ed khi qu\u00e1 li\u1ec1u:<\/em> khi b\u1ecb h\u1ea1 huy\u1ebft \u00e1p nghi\u00eam tr\u1ecdng, b\u1ecb ch\u1eadm nh\u1ecbp v\u00e0 b\u1ea5t t\u1ec9nh, c\u1ea7n theo d\u00f5i tim m\u1ea1ch v\u00e0 h\u00f4 h\u1ea5p v\u00e0 c\u1ea7n c\u00f3 bi\u1ec7n ph\u00e1p h\u1ed7 tr\u1ee3 k\u1ecbp th\u1eddi. V\u00ec Lercanidipin c\u00f3 t\u00ednh th\u00e2n d\u1ea7u cao, kh\u00f4ng th\u1ec3 d\u00f9ng th\u1ea9m t\u00e1ch m\u00e1u \u0111\u1ec3 th\u1ea3i tr\u1eeb.<\/p>\n<h1><span class=\"ez-toc-section\" id=\"5-co-che-tac-dung-cua-thuoc\"><\/span>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"51-duoc-luc-hoc\"><\/span>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Lercanidipin l\u00e0 m\u1ed9t ch\u1ea5t ch\u1eb9n k\u00eanh calci trong nh\u00f3m dihydropyridin. Lercanidipin \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc d\u00f2ng calci \u0111i xuy\u00ean qua m\u00e0ng v\u00e0o trong c\u00e1c c\u01a1 tr\u01a1n m\u1ea1ch m\u00e1u v\u00e0 tim, trong \u0111\u00f3 t\u00e1c d\u1ee5ng l\u00ean c\u01a1 tr\u01a1n m\u1ea1ch m\u00e1u m\u1ea1nh h\u01a1n c\u01a1 tr\u01a1n tim. Lercanidipin c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng t\u0103ng huy\u1ebft \u00e1p l\u00e0 do thu\u1ed1c l\u00e0m gi\u00e3n tr\u1ef1c ti\u1ebfp c\u01a1 tr\u01a1n, l\u00e0m gi\u1ea3m s\u1ee9c c\u1ea3n ngo\u1ea1i bi\u00ean to\u00e0n ph\u1ea7n v\u00ec v\u1eady l\u00e0m gi\u1ea3m huy\u1ebft \u00e1p. Lercanidipin ch\u1ed1ng t\u0103ng huy\u1ebft \u00e1p k\u00e9o d\u00e0i do n\u00f3 c\u00f3 c\u00f3 t\u00ednh th\u00e2n d\u1ea7u cao. Do t\u00e1c d\u1ee5ng gi\u00e3n m\u1ea1ch t\u1eeb t\u1eeb c\u1ee7a Lercanidipin, hi\u1ebfm g\u1eb7p tr\u01b0\u1eddng h\u1ee3p h\u1ea1 huy\u1ebft \u00e1p c\u1ea5p t\u00ednh v\u1edbi ph\u1ea3n x\u1ea1 nh\u1ecbp nhanh \u1edf nh\u0169ng b\u1ec7nh nh\u00e2n t\u0103ng huy\u1ebft \u00e1p.<\/p>\n<p>Nh\u01b0 c\u00e1c thu\u1ed1c trong nh\u00f3m 1,4 -dihydropyridin kh\u00e1c, t\u00e1c d\u1ee5ng ch\u1ed1ng t\u0103ng huy\u1ebft \u00e1p c\u1ee7a Lercanidipin ch\u1ee7 y\u1ebfu l\u00e0 \u0111\u1ed3ng ph\u00e2n \u0111\u1ed1i quang (S). Kh\u00f4ng th\u1ea5y \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 c\u1ee7a thu\u1ed1c tr\u00ean \u0111i\u1ec7n t\u00e2m \u0111\u1ed3.<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>Thu\u1ed1c \u1ee9c ch\u1ebf calci c\u00f3 ch\u1ecdn l\u1ecdc, t\u00e1c d\u1ee5ng ch\u1ee7 y\u1ebfu tr\u00ean m\u1ea1ch m\u00e1u.<\/p>\n<p>Lercanidipin thu\u1ed9c nh\u00f3m dihydropyridin, l\u00e0 ch\u1ea5t \u0111\u1ed1i kh\u00e1ng calci v\u00e0 \u1ee9c ch\u1ebf d\u00f2ng calci xuy\u00ean m\u00e0ng \u0111i v\u00e0o c\u01a1 tim v\u00e0 c\u01a1 tr\u01a1n. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng ch\u1ed1ng t\u0103ng huy\u1ebft \u00e1p c\u1ee7a thu\u1ed1c l\u00e0 do t\u00e1c d\u1ee5ng l\u00e0m gi\u00e3n tr\u1ef1c ti\u1ebfp c\u01a1 tr\u01a1n m\u1ea1ch m\u00e1u n\u00ean l\u00e0m gi\u1ea3m to\u00e0n th\u1ec3 kh\u00e1ng l\u1ef1c ngo\u1ea1i bi\u00ean. M\u1eb7c d\u1ea7u c\u00f3 th\u1eddi gian b\u00e1n th\u1ea3i d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc trong huy\u1ebft t\u01b0\u01a1ng ng\u1eafn, lercanidipin l\u1ea1i c\u00f3 t\u00e1c d\u1ee5ng h\u1ea1 \u00e1p k\u00e9o d\u00e0i do h\u1ec7 s\u1ed1 ph\u00e2n b\u1ed1 c\u1ee7a thu\u1ed1c tr\u00ean th\u00e0nh m\u1ea1ch cao h\u01a1n trong l\u00f2ng m\u1ea1ch m\u00e1u v\u00e0 do t\u00ednh ch\u1ecdn l\u1ecdc m\u1ea1ch m\u00e1u cao n\u00ean kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng b\u1ea5t l\u1ee3i tr\u00ean s\u1ee9c co b\u00f3p c\u01a1 tim. V\u00ec t\u00e1c \u0111\u1ed9ng gi\u00e3n m\u1ea1ch c\u1ee7a Lercanidipin l\u00e0 d\u1ea7n d\u1ea7n kh\u1edfi ph\u00e1t, n\u00ean hi\u1ebfm g\u1eb7p t\u00ecnh tr\u1ea1ng h\u1ea1 huy\u1ebft \u00e1p c\u1ea5p t\u00ednh k\u00e8m nh\u1ecbp tim nhanh do ph\u1ea3n x\u1ea1 \u1edf b\u1ec7nh nh\u00e2n t\u0103ng huy\u1ebft \u00e1p.<\/p>\n<p><a href=\"https:\/\/www.youtube.com\/watch?v=F1Pl4DO5flA\"><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/a><\/p>\n<h2><span class=\"ez-toc-section\" id=\"52-duoc-dong-hoc\"><\/span>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>H\u1ea5p thu:<\/em><\/p>\n<p>Lercanidipin \u0111\u01b0\u1ee3c h\u1ea5p thu ho\u00e0n to\u00e0n sau khi u\u1ed1ng. N\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh l\u1ea7n l\u01b0\u1ee3t \u0111\u1ea1t 3.30 ng\/ml \u00b1 2,09 SD v\u00e0 7,66 ng\/ml \u00b1 5,90 SD trong th\u1eddi gian 1,5 t\u1edbi 3 gi\u1edd sau khi u\u1ed1ng li\u1ec1u 10 mg v\u00e0 20 mg. Sinh kh\u1ea3 d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng kho\u1ea3ng 10% do thu\u1ed1c b\u1ecb chuy\u1ec3n h\u00f3a cao \u1edf l\u1ea7n \u0111\u1ea7u. Sinh kh\u1ea3 d\u1ee5ng t\u0103ng g\u1ea5p 4 l\u1ea7n khi Lercanidipin \u0111\u01b0\u1ee3c u\u1ed1ng h\u01a1n 2 gi\u1edd sau khi \u0103n nhi\u1ec1u ch\u1ea5t b\u00e9o v\u00e0 cao g\u1ea5p 2 l\u1ea7n n\u1ebfu u\u1ed1ng ngay khi v\u1eeba \u0103n nhi\u1ec1u carbonhydrat. V\u00ec v\u1eady, Lercanidipin n\u00ean \u0111\u01b0\u1ee3c u\u1ed1ng \u00edt nh\u1ea5t 15 ph\u00fat tr\u01b0\u1edbc khi b\u1eefa \u0103n.<\/p>\n<p>Khi d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng, d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a Lercanidipin l\u00e0 kh\u00f4ng tuy\u1ebfn t\u00ednh. Sau khi d\u00f9ng li\u1ec1u 10, 20 v\u00e0 40 mg, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh \u0111\u1ea1t theo t\u1ec9 l\u1ec7 1:3:8 v\u00e0 di\u1ec7n t\u00edch d\u01b0\u1edbi \u0111\u01b0\u1eddng cong \u0111\u1ea1t t\u1ec9 l\u1ec7 1:4:18, k\u1ebft qu\u1ea3 n\u00e0y l\u00e0 do chuy\u1ec3n h\u00f3a l\u1ea7n \u0111\u1ea7u c\u1ee7a thu\u1ed1c. \u0110i\u1ec1u n\u00e0y ch\u1ee9ng t\u1ecf sinh kh\u1ea3 d\u1ee5ng t\u0103ng l\u00ean khi t\u0103ng li\u1ec1u.<\/p>\n<p>Hai \u0111\u1ed3ng ph\u00e2n \u0111\u1ed1i quang c\u1ee7a Lercanidipin c\u00f3 c\u00f9ng th\u1eddi gian \u0111\u1ec3 \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh. Trung b\u00ecnh n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh v\u00e0 AUC c\u1ee7a \u0111\u1ed3ng ph\u00e2n s cao g\u1ea5p 1,2 l\u1ea7n. Kh\u00f4ng th\u1ea5y s\u1ef1 chuy\u1ec3n \u0111\u1ed5i qua l\u1ea1i gi\u1eefa c\u00e1c \u0111\u1ed3ng ph\u00e2n \u1edf in vivo.<\/p>\n<p><em>Ph\u00e2n b\u1ed1:<\/em><\/p>\n<p>Lercanidipin \u0111\u01b0\u1ee3c ph\u00e2n b\u1ed1 nhanh v\u00e0 r\u1ed9ng t\u1eeb m\u00e1u v\u00e0o c\u00e1c m\u00f4 v\u00e0 t\u1ed5 ch\u1ee9c. Thu\u1ed1c li\u00ean k\u1ebft tr\u00ean 98% v\u1edbi protein huy\u1ebft thanh. N\u1ed3ng \u0111\u1ed9 Lercanidipin t\u1ef1 do c\u00f3 th\u1ec3 t\u0103ng l\u00ean \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn suy gan v\u00ec n\u1ed3ng \u0111\u1ed9 protein huy\u1ebft thanh gi\u1ea3m v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y.<\/p>\n<p><em>Chuy\u1ec3n h\u00f3a:<\/em><\/p>\n<p>Gi\u1ed1ng c\u00e1c d\u1eabn ch\u1ea5t c\u1ee7a dihydropurin, Lercanidipin \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a ch\u00ednh b\u1edfi CYP3A4. thu\u1ed1c ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c chuy\u1ec3n th\u00e0nh c\u00e1c ch\u1ea5t kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh, kh\u00f4ng t\u00ecm th\u1ea5y ch\u1ea5t m\u1eb9 trong ph\u00e2n v\u00e0 n\u01b0\u1edbc ti\u1ec3u. G\u1ea7n 50% thu\u1ed1c \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft v\u00e0o n\u01b0\u1edbc ti\u1ec3u.<\/p>\n<p><em>Th\u1ea3i tr\u1eeb:<\/em><\/p>\n<p>Th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh c\u00f9a \u0111\u1ed3ng ph\u00e2n s v\u00e0 R l\u1ea7n l\u01b0\u1ee3t l\u00e0 5,8 \u00b1 2,5 v\u00e0 7,7 \u00b1 3 8 gi\u1edd. Kh\u00f4ng th\u1ea5y t\u00edch l\u0169y thu\u1ed1c khi d\u00f9ng li\u1ec1u nh\u1eafc l\u1ea1i. T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c k\u00e9o d\u00e0i 24 gi\u1edd l\u00e0 do thu\u1ed1c li\u00ean k\u1ebft cao v\u1edbi lipid m\u00e0ng t\u1ebf b\u00e0o.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"53-giai-thich\"><\/span>5.3 Gi\u1ea3i th\u00edch:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"54-thay-the-thuoc\"><\/span>5.4 Thay th\u1ebf thu\u1ed1c :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h1><span class=\"ez-toc-section\" id=\"6-phan-thong-tin-kem-theo-cua-thuoc\"><\/span>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"61-danh-muc-ta-duoc\"><\/span>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Tinh b\u1ed9t ng\u00f4, natri starch glycolate (Type A), colloidal Silicon dioxide, cellulose microcrystalline (pH 113), poloxamer 188, sodium stearyl h\u01b0narate, macrogol 6000, hypromellose 6 cps, s\u1eaft oxyd v\u00e0ng (E 172), Titan dioxyd(E 171).<\/p>\n<h2><span class=\"ez-toc-section\" id=\"62-tuong-ky\"><\/span>6.2. T\u01b0\u01a1ng k\u1ef5 :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Kh\u00f4ng \u00e1p d\u1ee5ng.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"63-bao-quan\"><\/span>6.3. B\u1ea3o qu\u1ea3n:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>N\u01a1i kh\u00f4, tr\u00e1nh \u00e1nh s\u00e1ng, nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30\u00b0C.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"64-thong-tin-khac\"><\/span>6.4. Th\u00f4ng tin kh\u00e1c :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Kh\u00f4ng c\u00f3.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"65-tai-lieu-tham-khao\"><\/span>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n<p>Ho\u1eb7c HDSD Thu\u1ed1c.<\/p>\n<h1><span class=\"ez-toc-section\" id=\"7-nguoi-dang-tai-tac-gia\"><\/span>7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p>B\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c s\u01b0u t\u1ea7m ho\u1eb7c vi\u1ebft b\u1edfi: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-tac-gia-bac-sy-do-my-linh\/\">B\u00e1c s\u0129 nhi khoa &#8211; \u0110\u1ed7 M\u1ef9 Linh.<\/a><\/p>\n<p>Ki\u1ec3m duy\u1ec7t , hi\u1ec7u \u0111\u00ednh v\u00e0 \u0111\u0103ng t\u1ea3i: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-ve-pharmog-team\/\">PHARMOG TEAM<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Toropi l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Toropi (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;) 1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Lercanidipine Ph\u00e2n lo\u1ea1i: Thu\u1ed1c ch\u1eb9n k\u00eanh calci. Nh\u00f3m [&hellip;]<\/p>\n","protected":false},"author":8612,"featured_media":33695,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[1310],"class_list":["post-33694","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-lercanidipine"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/33694","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/8612"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=33694"}],"version-history":[{"count":3,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/33694\/revisions"}],"predecessor-version":[{"id":44667,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/33694\/revisions\/44667"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/33695"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=33694"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=33694"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=33694"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}