{"id":31126,"date":"2021-05-05T09:59:22","date_gmt":"2021-05-05T02:59:22","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=31126"},"modified":"2025-01-07T23:07:14","modified_gmt":"2025-01-07T16:07:14","slug":"mirtazapine-aurozapine","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/","title":{"rendered":"Mirtazapine &#8211; Aurozapine"},"content":{"rendered":"<p><em>Thu\u1ed1c Aurozapine l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Aurozapine (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;)<\/em><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_81 ez-toc-wrap-left counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">N\u1ed9i dung ch\u00ednh<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#1-ten-hoat-chat-va-biet-duoc\" >1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#2-dang-bao-che-%e2%80%93-ham-luong\" >2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#3-video-by-pharmog\" >3. Video by Pharmog:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#4-ung-dung-lam-sang\" >4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng:<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#41-chi-dinh\" >4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#42-lieu-dung-%e2%80%93-cach-dung\" >4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#43-chong-chi-dinh\" >4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#44-than-trong\" >4.4 Th\u1eadn tr\u1ecdng:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#45-su-dung-cho-phu-nu-co-thai-va-cho-con-bu\" >4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#46-tac-dung-khong-mong-muon-adr\" >4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#47-huong-dan-cach-xu-tri-adr\" >4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#48-tuong-tac-voi-cac-thuoc-khac\" >4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#49-qua-lieu-va-xu-tri\" >4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#5-co-che-tac-dung-cua-thuoc\" >5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#51-duoc-luc-hoc\" >5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#52-duoc-dong-hoc\" >5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#53-giai-thich\" >5.3 Gi\u1ea3i th\u00edch:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#54-thay-the-thuoc\" >5.4 Thay th\u1ebf thu\u1ed1c :<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#6-phan-thong-tin-kem-theo-cua-thuoc\" >6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#61-danh-muc-ta-duoc\" >6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#62-tuong-ky\" >6.2. T\u01b0\u01a1ng k\u1ef5 :<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#63-bao-quan\" >6.3. B\u1ea3o qu\u1ea3n:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#64-thong-tin-khac\" >6.4. Th\u00f4ng tin kh\u00e1c :<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#65-tai-lieu-tham-khao\" >6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/pharmog.com\/wp\/mirtazapine-aurozapine\/#7-nguoi-dang-tai-tac-gia\" >7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<\/a><\/li><\/ul><\/nav><\/div>\n\n<h1><span class=\"ez-toc-section\" id=\"1-ten-hoat-chat-va-biet-duoc\"><\/span>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <\/strong><a href=\"https:\/\/pharmog.com\/wp\/mirtazapine\/\"><strong>Mirtazapine<\/strong><\/a><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m.<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): N06AX11.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em><\/strong> <a href=\"https:\/\/pharmog.com\/wp\/mirtazapine-remeron\/\">Remeron<\/a>.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c:<\/em><\/strong> Aurozapine<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: Aurobindo Pharma Limited<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h1><span class=\"ez-toc-section\" id=\"2-dang-bao-che-%e2%80%93-ham-luong\"><\/span>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>Vi\u00ean n\u00e9n bao phim 15 mg.<\/p>\n<p>Vi\u00ean n\u00e9n ph\u00e2n t\u00e1n 30 mg.<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>AUROZAPINE OD 30<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean n\u00e9n ph\u00e2n t\u00e1n c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Mirtazapine<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>30 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img decoding=\"async\" class=\"wp-image-31128\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/05\/word-image-45.png\" \/><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>AUROZAPINE 15<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean n\u00e9n bao phim c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Mirtazapine<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>15 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"515\" height=\"316\" class=\"wp-image-31130\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/05\/word-image-46.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/05\/word-image-46.png 515w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/05\/word-image-46-300x184.png 300w\" sizes=\"auto, (max-width: 515px) 100vw, 515px\" \/><\/p>\n<h1><span class=\"ez-toc-section\" id=\"3-video-by-pharmog\"><\/span>3. Video by Pharmog:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<h1><span class=\"ez-toc-section\" id=\"4-ung-dung-lam-sang\"><\/span>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"41-chi-dinh\"><\/span>4.1. Ch\u1ec9 \u0111\u1ecbnh:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u0110i\u1ec1u tr\u1ecb b\u1ec7nh tr\u1ea7m c\u1ea3m.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"42-lieu-dung-%e2%80%93-cach-dung\"><\/span>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p>U\u1ed1ng c\u00f9ng v\u1edbi n\u01b0\u1edbc, kh\u00f4ng \u0111\u01b0\u1ee3c nhai thu\u1ed1c.<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p><em>Ng\u01b0\u1eddi l\u1edbn:<\/em>\u00a0b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb v\u1edbi li\u1ec1u 15 mg\/ng\u00e0y. Xem l\u1ea1i li\u1ec1u v\u00e0 \u0111i\u1ec1u ch\u1ec9nh n\u1ebfu c\u1ea7n thi\u1ebft sau 2-4 tu\u1ea7n \u0111i\u1ec1u tr\u1ecb \u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c \u0111\u00e1p \u1ee9ng l\u00e2m s\u00e0ng t\u1ed1i \u01b0u. Li\u1ec1u t\u1ed1i \u0111a l\u00e0 45 mg\/ng\u00e0y.<\/p>\n<p><em>\u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n cao tu\u1ed5i:<\/em>\u00a0Li\u1ec1u cho b\u1ec7nh nh\u00e2n cao tu\u1ed5i c\u0169ng gi\u1ed1ng li\u1ec1u d\u00f9ng cho ng\u01b0\u1eddi l\u1edbn. Ch\u1ec9 t\u0103ng li\u1ec1u cho b\u1ec7nh nh\u00e2n cao tu\u1ed5i khi \u0111\u01b0\u1ee3c theo d\u00f5i ch\u1eb7t ch\u1ebd \u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c \u0111\u00e1p \u1ee9ng mong mu\u1ed1n v\u00e0 an to\u00e0n.<\/p>\n<p><em>\u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n suy gan v\u00e0 suy th\u1eadn:\u00a0<\/em>Thanh th\u1ea3i c\u1ee7a mirtazapine c\u00f3 th\u1ec3 b\u1ecb gi\u1ea3m \u1edf b\u1ec7nh nh\u00e2n suy gan\/th\u1eadn. C\u1ea7n l\u01b0u \u00fd khi k\u00ea \u0111\u01a1n mirtazapine cho c\u00e1c b\u1ec7nh nh\u00e2n n\u00e0y. C\u00f3 th\u1ec3 ph\u1ea3i gi\u1ea3m li\u1ec1u d\u00f9ng mirtazapine t\u00f9y theo m\u1ee9c \u0111\u1ed9 suy gan\/th\u1eadn.<\/p>\n<p>Mirtazapine c\u00f3 th\u1eddi gian b\u00e1n h\u1ee7y l\u00e0 24 &#8211; 40 gi\u1edd, do \u0111\u00f3 c\u00f3 th\u1ec3 d\u00f9ng vi\u00ean n\u00e9n mirtazapine 1 l\u1ea7n\/ng\u00e0y. D\u00f9ng li\u1ec1u duy nh\u1ea5t v\u00e0o bu\u1ed5i t\u1ed1i tr\u01b0\u1edbc khi \u0111i ng\u1ee7. C\u0169ng c\u00f3 th\u1ec3 chia li\u1ec1u l\u00e0m 2 l\u1ea7n\/ng\u00e0y, u\u1ed1ng v\u00e0o bu\u1ed5i s\u00e1ng v\u00e0 bu\u1ed5i t\u1ed1i tr\u01b0\u1edbc khi \u0111i ng\u1ee7.<\/p>\n<p>Vi\u1ec7c \u0111i\u1ec1u tr\u1ecb ph\u1ea3i \u0111\u01b0\u1ee3c duy tr\u00ec li\u00ean t\u1ee5c t\u1edbi khi b\u1ec7nh nh\u00e2n ho\u00e0n to\u00e0n h\u1ebft c\u00e1c tri\u1ec7u ch\u1ee9ng trong 4-6 th\u00e1ng. Sau \u0111\u00f3 ng\u1eebng thu\u1ed1c d\u1ea7n d\u1ea7n. \u0110i\u1ec1u tr\u1ecb li\u1ec1u ph\u00f9 h\u1ee3p s\u1ebd mang l\u1ea1i hi\u1ec7u qu\u1ea3 t\u1ed1t h\u01a1n sau 2-4 tu\u1ea7n. N\u1ebfu th\u1ea5y \u0111\u00e1p \u1ee9ng k\u00e9m, c\u00f3 th\u1ec3 t\u0103ng d\u1ea7n li\u1ec1u l\u00ean t\u1edbi li\u1ec1u t\u1ed1i \u0111a. N\u1ebfu \u0111i\u1ec1u tr\u1ecb li\u1ec1u t\u1ed1i \u0111a trong kho\u1ea3ng th\u1eddi gian 2-4 tu\u1ea7n m\u00e0 kh\u00f4ng c\u00f3 \u0111\u00e1p \u1ee9ng th\u00ec c\u1ea7n ng\u1eebng thu\u1ed1c.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"43-chong-chi-dinh\"><\/span>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>M\u1eabn c\u1ea3m v\u1edbi mirtazapine hay b\u1ea5t c\u1ee9 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p>Ph\u1ee5 n\u1eef mang thai v\u00e0 cho con b\u00fa.<\/p>\n<p>Tr\u1ebb em d\u01b0\u1edbi 18 tu\u1ed5i v\u00ec an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 ch\u01b0a \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 (xem ph\u1ea7n C\u1ea3nh b\u00e1o v\u00e0 th\u1eadn tr\u1ecdng).<\/p>\n<p>S\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi mirtazapine v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf MAO (xem ph\u1ea7n T\u01b0\u01a1ng t\u00e1c thu\u1ed1c).<\/p>\n<h2><span class=\"ez-toc-section\" id=\"44-than-trong\"><\/span>4.4 Th\u1eadn tr\u1ecdng:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>\u0110\u1ed1i v\u1edbi tr\u1ebb em:<\/em><\/p>\n<p>Kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng thu\u1ed1c trong \u0111i\u1ec1u tr\u1ecb cho b\u1ec7nh nh\u00e2n d\u01b0\u1edbi 18 tu\u1ed5i. H\u00e0nh vi li\u00ean quan \u0111\u1ebfn t\u1ef1 t\u1eed (c\u1ed1 g\u1eafng t\u1ef1 t\u1eed v\u00e0 \u00fd ngh\u0129 t\u1ef1 t\u1eed), s\u1ef1 th\u00f9 \u0111\u1ecbch (ch\u1ee7 y\u1ebfu l\u00e0 g\u00e2y h\u1ea5n, h\u00e0nh vi ch\u1ed1ng \u0111\u1ed1i v\u00e0 t\u1ee9c gi\u1eadn) \u0111\u00e3 \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y th\u01b0\u1eddng xuy\u00ean h\u01a1n trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u1edf tr\u1ebb em \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m so v\u1edbi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng gi\u1ea3 d\u01b0\u1ee3c. N\u1ebfu c\u0103n c\u1ee9 v\u00e0o nhu c\u1ea7u l\u00e2m s\u00e0ng c\u1ea7n s\u1eed d\u1ee5ng thu\u1ed1c \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb th\u00ec b\u1ec7nh nh\u00e2n ph\u1ea3i \u0111\u01b0\u1ee3c gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd c\u00e1c bi\u1ec3u hi\u1ec7n c\u1ee7a tri\u1ec7u ch\u1ee9ng t\u1ef1 t\u1eed. Ch\u01b0a c\u00f3 d\u1eef li\u1ec7u nghi\u00ean c\u1ee9u an to\u00e0n l\u00e2u d\u00e0i \u1edf tr\u1ebb em li\u00ean quan \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n, tr\u01b0\u1edfng th\u00e0nh v\u00e0 ph\u00e1t tri\u1ec3n v\u1ec1 m\u1eb7t nh\u1eadn th\u1ee9c v\u00e0 h\u00e0nh vi.<\/p>\n<p><em>T\u1ef1 t\u1eed\/\u00fd ngh\u0129 t\u1ef1 t\u1eed ho\u1eb7c bi\u1ec3u hi\u1ec7n l\u00e2m s\u00e0ng x\u1ea5u:<\/em><\/p>\n<p>Tr\u1ea7m c\u1ea3m c\u00f3 li\u00ean quan v\u1edbi t\u0103ng nguy c\u01a1 suy ngh\u0129 t\u1ef1 t\u1eed, t\u1ef1 g\u00e2y t\u1ed5n th\u01b0\u01a1ng v\u00e0 h\u00e0nh \u0111\u1ed9ng t\u1ef1 t\u1eed (c\u00e1c s\u1ef1 ki\u1ec7n li\u00ean quan \u0111\u1ebfn t\u1ef1 t\u1eed). Nguy c\u01a1 n\u00e0y v\u1eabn c\u00f2n t\u1ed3n t\u1ea1i cho \u0111\u1ebfn khi c\u00f3 s\u1ef1 thuy\u00ean gi\u1ea3m b\u1ec7nh \u0111\u00e1ng k\u1ec3. Tuy nhi\u00ean ti\u1ebfn tri\u1ec3n b\u1ec7nh c\u00f3 th\u1ec3 kh\u00f4ng x\u1ea3y ra trong nh\u1eefng tu\u1ea7n \u0111\u1ea7u ti\u00ean ho\u1eb7c l\u00e2u h\u01a1n trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb, b\u1ec7nh nh\u00e2n c\u1ea7n \u0111\u01b0\u1ee3c theo d\u00f5i ch\u1eb7t ch\u1ebd cho \u0111\u1ebfn khi b\u1ec7nh \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n. Kinh nghi\u1ec7m l\u00e2m s\u00e0ng chung cho th\u1ea5y r\u1eb1ng nguy c\u01a1 t\u1ef1 t\u1eed c\u00f3 th\u1ec3 t\u0103ng trong giai \u0111o\u1ea1n \u0111\u1ea7u c\u1ee7a s\u1ef1 ph\u1ee5c h\u1ed3i.<\/p>\n<p>B\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed li\u00ean quan \u0111\u1ebfn s\u1ef1 ki\u1ec7n t\u1ef1 t\u1eed ho\u1eb7c th\u1ec3 hi\u1ec7n m\u1ed9t m\u1ee9c \u0111\u1ed9 m\u1ea1nh c\u1ee7a \u00fd ngh\u0129 t\u1ef1 s\u00e1t tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb \u0111\u01b0\u1ee3c cho l\u00e0 c\u00f3 nguy c\u01a1 l\u1edbn h\u01a1n v\u1edbi \u00fd ngh\u0129 t\u1ef1 t\u1eed ho\u1eb7c h\u00e0nh \u0111\u1ed9ng t\u1ef1 t\u1eed, c\u1ea7n nh\u1eadn \u0111\u01b0\u1ee3c gi\u00e1m s\u00e1t c\u1ea9n th\u1eadn trong khi \u0111i\u1ec1u tr\u1ecb. M\u1ed9t ph\u00e2n t\u00edch t\u1ed5ng h\u1ee3p c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u0111\u1ed1i ch\u1ee9ng gi\u1ea3 d\u01b0\u1ee3c c\u1ee7a thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m \u1edf b\u1ec7nh nh\u00e2n ng\u01b0\u1eddi l\u1edbn b\u1ecb r\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n cho th\u1ea5y s\u1ef1 gia t\u0103ng nguy c\u01a1 c\u1ee7a h\u00e0nh vi t\u1ef1 t\u1eed v\u1edbi thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c \u1edf b\u1ec7nh nh\u00e2n d\u01b0\u1edbi 25 tu\u1ed5i.<\/p>\n<p>Gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd v\u1edbi b\u1ec7nh nh\u00e2n, \u0111\u1eb7c bi\u1ec7t v\u1edbi nh\u00f3m c\u00f3 nguy c\u01a1 cao n\u00ean song h\u00e0nh c\u00f9ng v\u1edbi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m \u0111\u1eb7c bi\u1ec7t l\u00e0 trong \u0111i\u1ec1u tr\u1ecb s\u1edbm v\u00e0 thay \u0111\u1ed5i li\u1ec1u l\u01b0\u1ee3ng. B\u1ec7nh nh\u00e2n (v\u00e0 nh\u1eefng ng\u01b0\u1eddi ch\u0103m s\u00f3c b\u1ec7nh nh\u00e2n) n\u00ean \u0111\u01b0\u1ee3c c\u1ea3nh b\u00e1o v\u1ec1 s\u1ef1 c\u1ea7n thi\u1ebft c\u1ee7a vi\u1ec7c gi\u00e1m s\u00e1t bi\u1ec3u hi\u1ec7n l\u00e2m s\u00e0ng x\u1ea5u \u0111i, h\u00e0nh vi t\u1ef1 t\u1eed ho\u1eb7c nh\u1eefng suy ngh\u0129 v\u00e0 nh\u1eefng thay \u0111\u1ed5i b\u1ea5t th\u01b0\u1eddng trong h\u00e0nh vi c\u1ee7a b\u1ec7nh nh\u00e2n \u0111\u1ec3 t\u00ecm t\u01b0 v\u1ea5n y t\u1ebf ngay l\u1eadp t\u1ee9c n\u1ebfu nh\u1eefng tri\u1ec7u ch\u1ee9ng n\u00e0y x\u1ea3y ra.<\/p>\n<p>Khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb, ch\u1ec9 n\u00ean cung c\u1ea5p m\u1ed9t s\u1ed1 l\u01b0\u1ee3ng nh\u1ecf thu\u1ed1c Mirtazapine cho b\u1ec7nh nh\u00e2n.<\/p>\n<p>R\u1ed1i lo\u1ea1n b\u1ea1ch c\u1ea7u h\u1ed3i ph\u1ee5c \u0111\u01b0\u1ee3c bao g\u1ed3m gi\u1ea3m b\u1ea1ch c\u1ea7u, m\u1ea5t ho\u1eb7c gi\u1ea3m b\u1ea1ch c\u1ea7u h\u1ea1t hi\u1ebfm khi g\u1eb7p v\u1edbi mirtazapine. H\u1ea7u h\u1ebft ch\u00fang xu\u1ea5t hi\u1ec7n sau kho\u1ea3ng 4-6 tu\u1ea7n \u0111i\u1ec1u tr\u1ecb v\u00e0 th\u01b0\u1eddng ph\u1ee5c h\u1ed3i khi ng\u1eebng \u0111i\u1ec1u tr\u1ecb. V\u1ec1 ch\u1ee9ng m\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t, b\u00e1c s\u0129 c\u1ea7n c\u1ea3nh b\u00e1o cho b\u1ec7nh nh\u00e2n nh\u1eefng bi\u1ec3u hi\u1ec7n nh\u01b0 s\u1ed1t, vi\u00eam h\u1ecdng, vi\u00eam mi\u1ec7ng ho\u1eb7c c\u00e1c d\u1ea5u hi\u1ec7u nhi\u1ec5m tr\u00f9ng kh\u00e1c, khi c\u00e1c d\u1ea5u hi\u1ec7u n\u00e0y x\u1ea3y ra th\u00ec ph\u1ea3i ng\u1eebng thu\u1ed1c v\u00e0 x\u00e9t nghi\u1ec7m m\u00e1u. B\u1ec7nh nh\u00e2n c\u1ea7n \u0111\u01b0\u1ee3c bi\u1ebft t\u1ea7m quan tr\u1ecdng c\u1ee7a c\u00e1c tri\u1ec7u ch\u1ee9ng tr\u00ean.<\/p>\n<p>Th\u1eadn tr\u1ecdng khi ch\u1ec9nh li\u1ec1u v\u00e0 gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd\/th\u01b0\u1eddng xuy\u00ean cho c\u00e1c b\u1ec7nh nh\u00e2n sau:<\/p>\n<p>B\u1ec7nh \u0111\u1ed9ng kinh v\u00e0 h\u1ed9i ch\u1ee9ng n\u00e3o th\u1ef1c th\u1ec3: C\u0169ng gi\u1ed1ng nh\u01b0 c\u00e1c thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m kh\u00e1c, d\u00f9ng th\u1eadn tr\u1ecdng mirtazapine cho nh\u1eefng ng\u01b0\u1eddi c\u00f3 ti\u1ec1n s\u1eed \u0111\u1ed9ng kinh. Ng\u1eebng d\u00f9ng mirtazapine n\u1ebfu xu\u1ea5t hi\u1ec7n co gi\u1eadt hay c\u00f3 t\u0103ng t\u1ea7n su\u1ea5t co gi\u1eadt. Kh\u00f4ng d\u00f9ng c\u00e1c thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m cho nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb \u0111\u1ed9ng kinh\/co gi\u1eadt ch\u01b0a \u1ed5n \u0111\u1ecbnh v\u00e0 th\u1eadn tr\u1ecdng khi d\u00f9ng cho nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u1ed9ng kinh \u0111\u00e3 \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t.<\/p>\n<p>Suy gan ho\u1eb7c suy th\u1eadn.<\/p>\n<p>B\u1ec7nh v\u1ec1 tim nh\u01b0 r\u1ed1i lo\u1ea1n d\u1eabn truy\u1ec1n, \u0111au th\u1eaft ng\u1ef1c hay nh\u1ed3i m\u00e1u c\u01a1 tim m\u1edbi \u0111\u00e2y: c\u1ea7n \u00e1p d\u1ee5ng c\u00e1c th\u1eadn tr\u1ecdng th\u00f4ng th\u01b0\u1eddng v\u00e0 gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd c\u00e1c thu\u1ed1c d\u00f9ng \u0111\u1ed3ng th\u1eddi.<\/p>\n<p>Huy\u1ebft \u00e1p th\u1ea5p.<\/p>\n<p>B\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng: \u0110\u1ed1i v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng, c\u00e1c thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m c\u00f3 th\u1ec3 l\u00e0m \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn vi\u1ec7c ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft. C\u00f3 th\u1ec3 c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u Insulin hay c\u00e1c thu\u1ed1c h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft \u0111\u01b0\u1eddng u\u1ed1ng, ph\u1ea3i gi\u00e1m s\u00e1t b\u1ec7nh nh\u00e2n ch\u1eb7t ch\u1ebd.<\/p>\n<p>C\u0169ng gi\u1ed1ng nh\u01b0 c\u00e1c thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m kh\u00e1c, c\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng mirtazapine cho c\u00e1c b\u1ec7nh nh\u00e2n sau:<\/p>\n<p>R\u1ed1i lo\u1ea1n \u0111i ti\u1ec3u hay ph\u00ec \u0111\u1ea1i tuy\u1ebfn ti\u1ec1n li\u1ec7t (m\u1eb7c d\u00f9 r\u1ea5t \u00edt kh\u1ea3 n\u0103ng c\u00f3 v\u1ea5n \u0111\u1ec1 v\u1edbi mirtazapine do t\u00e1c d\u1ee5ng kh\u00e1ng cholinergic c\u1ee7a mirtazapine l\u00e0 r\u1ea5t th\u1ea5p).<\/p>\n<p>B\u1ec7nh Gl\u00f4c\u00f4m g\u00f3c h\u1eb9p c\u1ea5p v\u00e0 t\u0103ng \u00e1p l\u1ef1c n\u1ed9i nh\u00e3n (m\u1eb7c d\u00f9 r\u1ea5t \u00edt kh\u1ea3 n\u0103ng c\u00f3 v\u1ea5n \u0111\u1ec1 v\u1edbi mirtazapine do t\u00e1c d\u1ee5ng kh\u00e1ng cholinergic c\u1ee7a mirtazapine l\u00e0 r\u1ea5t th\u1ea5p).<\/p>\n<p>Ng\u1eebng \u0111i\u1ec1u tr\u1ecb n\u1ebfu x\u1ea3y ra v\u00e0ng da. Ngo\u00e0i ra, nh\u01b0 c\u00e1c thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m kh\u00e1c, c\u00e1c b\u1ec7nh nh\u00e2n c\u1ea7n l\u01b0u \u00fd:<\/p>\n<p>C\u00e1c tri\u1ec7u ch\u1ee9ng t\u00e2m th\u1ea7n c\u00f3 th\u1ec3 t\u0103ng l\u00ean khi d\u00f9ng thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m cho nh\u1eefng b\u1ec7nh nh\u00e2n t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t ho\u1eb7c c\u00e1c r\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n kh\u00e1c; t\u0103ng \u00fd ngh\u0129 hoang t\u01b0\u1edfng.<\/p>\n<p>Khi \u0111ang \u0111i\u1ec1u tr\u1ecb giai \u0111o\u1ea1n tr\u1ea7m c\u1ea3m c\u1ee7a b\u1ec7nh t\u00e2m th\u1ea7n h\u01b0ng tr\u1ea7m c\u1ea3m, b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 chuy\u1ec3n sang giai \u0111o\u1ea1n h\u01b0ng c\u1ea3m.<\/p>\n<p>Nh\u01b0 v\u1edbi t\u1ea5t c\u1ea3 c\u00e1c thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m, thu\u1ed1c c\u00f3 th\u1ec3 ch\u01b0a c\u00f3 t\u00e1c d\u1ee5ng trong v\u00e0i tu\u1ea7n \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb, do v\u1eady b\u1ec7nh nh\u00e2n c\u1ea7n \u0111\u01b0\u1ee3c theo d\u00f5i ch\u1eb7t ch\u1ebd trong th\u1eddi gian n\u00e0y. \u00dd \u0111\u1ecbnh t\u1ef1 t\u1eed g\u1eafn li\u1ec1n v\u1edbi b\u1ec7nh tr\u1ea7m c\u1ea3m v\u00e0 k\u00e9o d\u00e0i cho t\u1edbi khi b\u1ec7nh c\u00f3 ti\u1ebfn tri\u1ec3n r\u00f5 r\u1ec7t.<\/p>\n<p>M\u1eb7c d\u00f9 c\u00e1c thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m kh\u00f4ng g\u00e2y nghi\u1ec7n nh\u01b0ng n\u1ebfu ng\u1eebng thu\u1ed1c \u0111\u1ed9t ng\u1ed9t khi d\u00f9ng th\u1eddi gian d\u00e0i c\u00f3 th\u1ec3 g\u00e2y \u0111au \u0111\u1ea7u, bu\u1ed3n n\u00f4n v\u00e0 kh\u00f3 \u1edf.<\/p>\n<p>Thu\u1ed1c c\u00f3 ch\u1ee9a lactose: kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c n\u00e0y cho b\u1ec7nh nh\u00e2n b\u1ecb c\u00e1c v\u1ea5n \u0111\u1ec1 di truy\u1ec1n hi\u1ebfm g\u1eb7p nh\u01b0 kh\u00f4ng dung n\u1ea1p galactose, thi\u1ebfu h\u1ee5t lapp &#8211; lactase hay k\u00e9m h\u1ea5p thu glucose &#8211; galactose.<\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>\u1ede m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u0111\u1ed1i v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n cao tu\u1ed5i, mirtazapine c\u00f3 th\u1ec3 c\u00f3 t\u00e1c d\u1ee5ng g\u00e2y ng\u1ee7 nh\u1eb9 v\u00e0 c\u00f3 th\u1ec3 l\u00e0m suy gi\u1ea3m s\u1ef1 t\u1ec9nh t\u00e1o v\u00e0 kh\u1ea3 n\u0103ng t\u1eadp trung. Do v\u1eady, khi d\u00f9ng mirtazapine b\u1ec7nh nh\u00e2n c\u1ea7n th\u1eadn tr\u1ecdng khi l\u00e1i xe hay v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h2><span class=\"ez-toc-section\" id=\"45-su-dung-cho-phu-nu-co-thai-va-cho-con-bu\"><\/span>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: B3<\/p>\n<p>US FDA pregnancy category: C<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>Kh\u00f4ng d\u00f9ng mirtazapine trong th\u1eddi k\u1ef3 mang thai v\u00e0 cho con b\u00fa.<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>Kh\u00f4ng d\u00f9ng mirtazapine trong th\u1eddi k\u1ef3 mang thai v\u00e0 cho con b\u00fa.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"46-tac-dung-khong-mong-muon-adr\"><\/span>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Nh\u1eefng b\u1ec7nh nh\u00e2n tr\u1ea7m c\u1ea3m th\u01b0\u1eddng g\u1eb7p m\u1ed9t s\u1ed1 tri\u1ec7u ch\u1ee9ng li\u00ean quan \u0111\u1ebfn ch\u00ednh b\u1ec7nh \u0111\u00f3. Do \u0111\u00f3 \u0111\u00f4i khi kh\u00f3 kh\u0103n \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh c\u00e1c tri\u1ec7u ch\u1ee9ng m\u1eafc ph\u1ea3i l\u00e0 do b\u1ec7nh hay do d\u00f9ng mirtazapine. Sau \u0111\u00e2y l\u00e0 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o, [hi\u1ebfm g\u1eb7p (&gt; 1\/10.000) \u00edt g\u1eb7p (&gt; 1\/1.000) v\u00e0 hay g\u1eb7p (&gt; 1\/100)].<\/p>\n<p><em>R\u1ed1i lo\u1ea1n m\u00e1u v\u00e0 h\u1ec7 b\u1ea1ch huy\u1ebft:<\/em><\/p>\n<p>Hi\u1ebfm g\u1eb7p: m\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t h\u1ed3i ph\u1ee5c \u0111\u01b0\u1ee3c.<\/p>\n<p><em>R\u1ed1i lo\u1ea1n dinh d\u01b0\u1ee1ng v\u00e0 chuy\u1ec3n h\u00f3a:<\/em><\/p>\n<p>Hay g\u1eb7p: th\u00e8m \u0103n v\u00e0 t\u0103ng c\u00e2n s\u1ebd quay tr\u1edf l\u1ea1i.<\/p>\n<p><em>R\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n:<\/em><\/p>\n<p>Hi\u1ebfm g\u1eb7p: \u00e1c m\u1ed9ng\/gi\u1ea5c m\u01a1 \u0111\u1ea7y m\u00e0u s\u1eafc, t\u00e2m th\u1ea7n b\u1ed3n ch\u1ed3n k\u00e8m ng\u1ed3i n\u1eb1m kh\u00f4ng y\u00ean.<\/p>\n<p><em>R\u1ed1i lo\u1ea1n h\u1ec7 th\u1ea7n kinh:<\/em><\/p>\n<p>\u00cdt g\u1eb7p: \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t.<\/p>\n<p><em>R\u1ed1i lo\u1ea1n tim:<\/em><\/p>\n<p>Hi\u1ebfm g\u1eb7p: H\u1ea1 huy\u1ebft \u00e1p th\u1ebf \u0111\u1ee9ng.<\/p>\n<p><em>R\u1ed1i lo\u1ea1n gan &#8211; m\u1eadt:<\/em><\/p>\n<p>\u00cdt g\u1eb7p: T\u0103ng n\u1ed3ng \u0111\u1ed9 enzym gan.<\/p>\n<p><em>R\u1ed1i lo\u1ea1n da v\u00e0 m\u00f4 d\u01b0\u1edbi da:<\/em><\/p>\n<p>Hi\u1ebfm g\u1eb7p: ban da.<\/p>\n<p><em>R\u1ed1i lo\u1ea1n c\u01a1 x\u01b0\u01a1ng, m\u00f4 li\u00ean k\u1ebft v\u00e0 x\u01b0\u01a1ng:<\/em><\/p>\n<p>Hi\u1ebfm g\u1eb7p: bu\u1ed3n b\u1ef1c \u1edf ch\u00e2n, \u0111au c\u01a1 v\u00e0 \u0111au kh\u1edbp.<\/p>\n<p><em>C\u00e1c r\u1ed1i lo\u1ea1n chung:<\/em><\/p>\n<p>Hay g\u1eb7p: Ph\u00f9 to\u00e0n th\u00e2n hay khu tr\u00fa, m\u1ec7t m\u1ecfi, ng\u1ee7 g\u00e0, bu\u1ed3n ng\u1ee7, th\u01b0\u1eddng x\u1ea3y ra trong v\u00e0i tu\u1ea7n \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb. Gi\u1ea3m li\u1ec1u th\u01b0\u1eddng kh\u00f4ng l\u00e0m gi\u1ea3m bu\u1ed3n ng\u1ee7 m\u00e0 l\u1ea1i \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn t\u00e1c d\u1ee5ng ch\u1ed1ng tr\u1ea7m c\u1ea3m.<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<h2><span class=\"ez-toc-section\" id=\"47-huong-dan-cach-xu-tri-adr\"><\/span>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c. V\u1edbi c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i nh\u1eb9, th\u01b0\u1eddng ch\u1ec9 c\u1ea7n ng\u1eebng thu\u1ed1c. Tr\u01b0\u1eddng h\u1ee3p m\u1eabn c\u1ea3m n\u1eb7ng ho\u1eb7c ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, c\u1ea7n ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 (gi\u1eef tho\u00e1ng kh\u00ed v\u00e0 d\u00f9ng epinephrin, th\u1edf oxygen, d\u00f9ng kh\u00e1ng histamin, corticoid&#8230;).<\/p>\n<h2><span class=\"ez-toc-section\" id=\"48-tuong-tac-voi-cac-thuoc-khac\"><\/span>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Mirtazapine l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng c\u1ee7a r\u01b0\u1ee3u, tr\u00e1nh u\u1ed1ng r\u01b0\u1ee3u trong khi d\u00f9ng mirtazapine. Kh\u00f4ng d\u00f9ng mirtazapine c\u00f9ng v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf MAO ho\u1eb7c trong v\u00f2ng 2 tu\u1ea7n sau khi d\u00f9ng c\u00e1c thu\u1ed1c n\u00e0y. Mirtazapine c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng an th\u1ea7n c\u1ee7a benzodiazepine, do v\u1eady th\u1eadn tr\u1ecdng khi k\u00ea \u0111\u01a1n mirtazapine c\u00f9ng benzodiazepine.<\/p>\n<p>Mirtazapine \u1ee9c ch\u1ebf r\u1ea5t y\u1ebfu c\u00e1c enzym c\u1ee7a h\u1ec7 cytochrom P450 l\u00e0 CYP1A2, CYP2D6, v\u00e0 CYP3A.<\/p>\n<p>C\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng mirtazapine c\u00f9ng v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf CYP3A4 m\u1ea1nh, nh\u01b0 c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf HIV protease, c\u00e1c thu\u1ed1c kh\u00e1ng n\u1ea5m nh\u00f3m azole, erythromycin v\u00e0 nefazodone.<\/p>\n<p>D\u00f9ng mirtazapine c\u00f9ng v\u1edbi ketoconazol, m\u1ed9t thu\u1ed1c \u1ee9c ch\u1ebf CYP3A4 m\u1ea1nh, l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng v\u00e0 AUC l\u00ean t\u01b0\u01a1ng \u1ee9ng 30 v\u00e0 45%. Carbamazepin, m\u1ed9t ch\u1ea5t g\u00e2y c\u1ea3m \u1ee9ng CYP3A4, l\u00e0m t\u0103ng thanh th\u1ea3i c\u1ee7a mirtazapine l\u00ean g\u00e2p \u0111\u00f4i, d\u1eabn \u0111\u1ebfn l\u00e0m gi\u1ea3m 45 &#8211; 60% n\u1ed3ng \u0111\u1ed9 mirtazapine trong huy\u1ebft t\u01b0\u01a1ng. T\u01b0\u01a1ng t\u1ef1 nh\u01b0 v\u1eady, phenytoin l\u00e0m t\u0103ng thanh th\u1ea3i c\u1ee7a mirtazapine. Khi d\u00f9ng th\u00eam carbamazepin hay m\u1ed9t thu\u1ed1c g\u00e2y c\u1ea3m \u1ee9ng chuy\u1ec3n h\u00f3a c\u1ee7a thu\u1ed1c nh\u01b0 rifampicin, th\u00ec c\u00f3 th\u1ec3 t\u0103ng li\u1ec1u mirtazapine. Khi ng\u1eebng d\u00f9ng thu\u1ed1c g\u00e2y c\u1ea3m \u1ee9ng, th\u00ec c\u1ea7n gi\u1ea3m li\u1ec1u d\u00f9ng miratazapine.<\/p>\n<p>Sinh kh\u1ea3 d\u1ee5ng c\u1ee7a mirazapine t\u0103ng l\u00ean h\u01a1n 50% khi d\u00f9ng k\u1ebft h\u1ee3p v\u1edbi cimetidin. Ph\u1ea3i gi\u1ea3m li\u1ec1u c\u1ee7a mirtazapine khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi cimetidin, v\u00e0 t\u0103ng li\u1ec1u l\u00ean khi ng\u1eebng d\u00f9ng cimetidin.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"49-qua-lieu-va-xu-tri\"><\/span>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>C\u00e1c tri\u1ec7u ch\u1ee9ng khi d\u00f9ng mirtazapine qu\u00e1 li\u1ec1u th\u01b0\u1eddng l\u00e0 nh\u1eb9.<\/p>\n<p>\u1ee8c ch\u1ebf h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng k\u00e8m m\u1ea5t \u0111\u1ecbnh h\u01b0\u1edbng, g\u00e2y ng\u1ee7 k\u00e9o d\u00e0i c\u00f3 th\u1ec3 x\u1ea3y ra, c\u00f9ng v\u1edbi nh\u1ecbp nhanh, t\u0103ng ho\u1eb7c gi\u1ea3m huy\u1ebft \u00e1p nh\u1eb9.<\/p>\n<p>Khi d\u00f9ng thu\u1ed1c qu\u00e1 li\u1ec1u, c\u1ea7n r\u1eeda d\u1ea1 d\u00e0y, \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 v\u00e0 \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng th\u00edch h\u1ee3p.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h1><span class=\"ez-toc-section\" id=\"5-co-che-tac-dung-cua-thuoc\"><\/span>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"51-duoc-luc-hoc\"><\/span>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Mirtazapine l\u00e0 m\u1ed9t ch\u1ea5t \u0111\u1ed1i kh\u00e1ng \u03b1 &#8211; 2 ti\u1ec1n synap t\u00e1c d\u1ee5ng trung \u01b0\u01a1ng, n\u00f3 l\u00e0m t\u0103ng d\u1eabn truy\u1ec1n th\u1ea7n kinh noradrenergic v\u00e0 serotonergic trung \u01b0\u01a1ng. S\u1ef1 t\u0103ng c\u00e1c d\u1eabn truy\u1ec1n th\u1ea7n kinh serotonergic l\u00e0 \u0111\u1eb7c hi\u1ec7u qua trung gian th\u1ee5 th\u1ec3 5 &#8211; HT<sub>1<\/sub>, v\u00ec c\u00e1c th\u1ee5 th\u1ec3 5 &#8211; HT<sub>2<\/sub>\u00a0v\u00e0 5 &#8211; HT<sub>3<\/sub>\u00a0b\u1ecb \u1ee9c ch\u1ebf b\u1edfi mirtazapine. C\u1ea3 hai \u0111\u1ed1i h\u00ecnh c\u1ee7a mirtazapine \u0111\u1ec1u c\u00f3 tham gia v\u00e0o t\u00e1c d\u1ee5ng ch\u1ed1ng tr\u1ea7m c\u1ea3m. \u0110\u1ed1i h\u00ecnh S (+) kh\u00f3a c\u00e1c th\u1ee5 th\u1ec3 \u03b1 &#8211; 2 v\u00e0 5 &#8211; HT<sub>2<\/sub>\u00a0c\u00f2n \u0111\u1ed1i h\u00ecnh R (-) kh\u00f3a c\u00e1c th\u1ee5 th\u1ec3 5 &#8211; HT<sub>3<\/sub><\/p>\n<p>Ho\u1ea1t t\u00ednh kh\u00e1ng histamin H<sub>1<\/sub>\u00a0c\u1ee7a mirtazapine khi\u1ebfn n\u00f3 c\u00f3 t\u00e1c d\u1ee5ng g\u00e2y ng\u1ee7. Nh\u00ecn chung, mirtazapine \u0111\u01b0\u1ee3c dung n\u1ea1p t\u1ed1t. Th\u1ef1c t\u1ebf, n\u00f3 kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh kh\u00e1ng cholinergic, v\u00e0 \u1edf li\u1ec1u \u0111i\u1ec1u tr\u1ecb n\u00f3 kh\u00f4ng c\u00f3 t\u00e1c \u0111\u1ed9ng l\u00ean h\u1ec7 tim m\u1ea1ch<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a mirtazapin hi\u1ec7n ch\u01b0a \u0111\u01b0\u1ee3c bi\u1ebft r\u00f5. C\u00f3 nh\u1eefng b\u1eb1ng ch\u1ee9ng t\u1eeb th\u1ef1c nghi\u1ec7m cho th\u1ea5y mirtazapin l\u00e0m t\u0103ng c\u01b0\u1eddng ho\u1ea1t t\u00ednh noradrenergic v\u00e0 serotoninergic trung \u01b0\u01a1ng c\u00f3 th\u1ec3 do t\u00e1c d\u1ee5ng \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 alpha<sub>2<\/sub> adrenergic ti\u1ec1n synap \u1edf th\u1ea7n kinh trung \u01b0\u01a1ng. Mirtazapin kh\u00f4ng c\u00f3 \u00e1i l\u1ef1c v\u1edbi th\u1ee5 th\u1ec3 5HT-1<sub>A<\/sub> v\u00e0 5HT-1<sub>B<\/sub> c\u1ee7a serotonin. Ngo\u00e0i ra, mirtazapin c\u00f2n \u0111\u1ed1i kh\u00e1ng m\u1ea1nh th\u1ee5 th\u1ec3 5HT-2 v\u00e0 5HT-3 c\u1ee7a serotonin \u0111\u1ed3ng th\u1eddi \u0111\u1ed1i kh\u00e1ng \u1edf m\u1ee9c \u0111\u1ed9 trung b\u00ecnh v\u1edbi th\u1ee5 th\u1ec3 muscarinic. Mirtazapin c\u00f3 t\u00e1c d\u1ee5ng g\u00e2y ng\u1ee7 do \u0111\u1ed1i kh\u00e1ng m\u1ea1nh th\u1ee5 th\u1ec3 H c\u1ee7a histamin v\u00e0 c\u00f3 t\u00e1c d\u1ee5ng g\u00e2y h\u1ea1 huy\u1ebft \u00e1p t\u01b0 th\u1ebf do \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 alpha<sub>l<\/sub>-adrenergic \u1edf ngo\u1ea1i vi.<\/p>\n<p><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/p>\n<h2><span class=\"ez-toc-section\" id=\"52-duoc-dong-hoc\"><\/span>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Sau khi u\u1ed1ng vi\u00ean n\u00e9n mirtazapine, ho\u1ea1t ch\u1ea5t mirtazapine h\u1ea5p thu nhanh v\u00e0 m\u1ea1nh (sinh kh\u1ea3 d\u1ee5ng c\u1ee7a mirtazapine l\u00e0 50%), n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t \u0111\u01b0\u1ee3c sau kho\u1ea3ng 2 gi\u1edd. M\u1ee9c \u0111\u1ed9 li\u00ean k\u1ebft c\u1ee7a mirtazapine v\u1edbi protein huy\u1ebft h\u01b0\u01a1ng kho\u1ea3ng 85%. Th\u1eddi gian b\u00e1n h\u1ee7y trung b\u00ecnh kho\u1ea3ng 20 &#8211; 40 gi\u1edd, \u0111\u00f4i khi k\u00e9o d\u00e0i t\u1edbi 65 gi\u1edd ho\u1eb7c b\u1ecb r\u00fat ng\u1eafn \u0111i \u1edf ng\u01b0\u1eddi tr\u1ebb tu\u1ed5i. Th\u1eddi gian b\u00e1n h\u1ee7y n\u00e0y ph\u00f9 h\u1ee3p v\u1edbi li\u1ec1u d\u00f9ng ng\u00e0y 1 l\u1ea7n. Tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh \u0111\u1ea1t \u0111\u01b0\u1ee3c sau 3-4 ng\u00e0y, sau \u0111\u00f3 thu\u1ed1c kh\u00f4ng c\u00f3 t\u00edch l\u0169y th\u00eam. Mirtazapine c\u00f3 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc tuy\u1ebfn t\u00ednh trong kho\u1ea3ng li\u1ec1u khuy\u1ebfn c\u00e1o. Th\u1ee9c \u0103n kh\u00f4ng c\u00f3 \u1ea3nh h\u01b0\u1edfng l\u00ean d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a mirtazapine. Mirtazapine b\u1ecb chuy\u1ec3n h\u00f3a m\u1ea1nh v\u00e0 th\u1ea3i tr\u1eeb qua n\u01b0\u1edbc ti\u1ec3u v\u00e0 ph\u00e2n trong v\u00e0i ng\u00e0y. Con \u0111\u01b0\u1eddng sinh chuy\u1ec3n h\u00f3a ch\u00ednh l\u00e0 demethyl h\u00f3a v\u00e0 oxi h\u00f3a, sau \u0111\u00f3 li\u00ean h\u1ee3p. C\u00e1c enzym cytochrom P450 CYP2D6 v\u00e0 CYP1A2 tham gia v\u00e0o qu\u00e1 tr\u00ecnh t\u1ea1o ch\u1ea5t chuy\u1ec3n h\u00f3a 8 &#8211; hydroxy c\u1ee7a mirtazapine, trong khi CYP3A4 tham gia t\u1ea1o ch\u1ea5t chuy\u1ec3n h\u00f3a N &#8211; demethyl v\u00e0 N -oxide. Ch\u1ea5t chuy\u1ec3n h\u00f3a demethyl c\u00f3 ho\u1ea1t t\u00ednh d\u01b0\u1ee3c l\u00fd v\u00e0 c\u00f9ng t\u00ednh ch\u1ea5t d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc nh\u01b0 ch\u1ea5t m\u1eb9. Kh\u00f4ng c\u00f3 kh\u00e1c bi\u1ec7t v\u1ec1 c\u00e1c th\u00f4ng s\u1ed1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a mirtazapine racemic v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a demethyl c\u1ee7a n\u00f3 \u1edf c\u1ea3 ng\u01b0\u1eddi chuy\u1ec3n h\u00f3a thu\u1ed1c m\u1ea1nh v\u00e0 y\u1ebfu. Thanh th\u1ea3i c\u1ee7a mirtazapine b\u1ecb gi\u1ea3m \u1edf ng\u01b0\u1eddi suy gan ho\u1eb7c suy th\u1eadn.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"53-giai-thich\"><\/span>5.3 Gi\u1ea3i th\u00edch:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"54-thay-the-thuoc\"><\/span>5.4 Thay th\u1ebf thu\u1ed1c :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<h1><span class=\"ez-toc-section\" id=\"6-phan-thong-tin-kem-theo-cua-thuoc\"><\/span>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<h2><span class=\"ez-toc-section\" id=\"61-danh-muc-ta-duoc\"><\/span>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>T\u00e1 d\u01b0\u1ee3c: Lactose monohydrat, hydroxypropyl cellulose, tinh b\u1ed9t ng\u00f4, keo silica khan, low substituted hydroxypropyl cellulose, magnesi stearat v\u00e0 opadry 20A52560 yellow.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"62-tuong-ky\"><\/span>6.2. T\u01b0\u01a1ng k\u1ef5 :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Kh\u00f4ng \u00e1p d\u1ee5ng.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"63-bao-quan\"><\/span>6.3. B\u1ea3o qu\u1ea3n:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Vi\u00ean n\u00e9n c\u00f3 ch\u1ee9a mirtazapin ph\u1ea3i \u0111\u01b0\u1ee3c b\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, tr\u00e1nh \u00e1nh s\u00e1ng, tr\u00e1nh \u1ea5m v\u00e0 \u1edf nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30 <sup>o<\/sup>C.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"64-thong-tin-khac\"><\/span>6.4. Th\u00f4ng tin kh\u00e1c :<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Kh\u00f4ng c\u00f3.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"65-tai-lieu-tham-khao\"><\/span>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n<p>Ho\u1eb7c HDSD Thu\u1ed1c.<\/p>\n<h1><span class=\"ez-toc-section\" id=\"7-nguoi-dang-tai-tac-gia\"><\/span>7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p>B\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c s\u01b0u t\u1ea7m ho\u1eb7c vi\u1ebft b\u1edfi: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-tac-gia-bac-sy-do-my-linh\/\">B\u00e1c s\u0129 nhi khoa &#8211; \u0110\u1ed7 M\u1ef9 Linh.<\/a><\/p>\n<p>Ki\u1ec3m duy\u1ec7t , hi\u1ec7u \u0111\u00ednh v\u00e0 \u0111\u0103ng t\u1ea3i: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-ve-pharmog-team\/\">PHARMOG TEAM<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Aurozapine l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Aurozapine (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;) 1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Mirtazapine Ph\u00e2n lo\u1ea1i: Thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m. Nh\u00f3m [&hellip;]<\/p>\n","protected":false},"author":8612,"featured_media":31127,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[1229],"class_list":["post-31126","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-mirtazapine"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/31126","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/8612"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=31126"}],"version-history":[{"count":2,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/31126\/revisions"}],"predecessor-version":[{"id":45757,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/31126\/revisions\/45757"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/31127"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=31126"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=31126"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=31126"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}