{"id":30661,"date":"2021-04-04T09:51:20","date_gmt":"2021-04-04T02:51:20","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=30661"},"modified":"2025-01-08T08:37:11","modified_gmt":"2025-01-08T01:37:11","slug":"rabeprazole-rabera-rab-ulcer","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/rabeprazole-rabera-rab-ulcer\/","title":{"rendered":"Rabeprazole &#8211; Rabera\/Rab-ulcer"},"content":{"rendered":"<p><em>Thu\u1ed1c Rabera , Rab-ulcer l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Rabera , Rab-ulcer (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;)<\/em><\/p>\n<p><strong>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: <\/strong><\/p>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <\/strong><a href=\"https:\/\/pharmog.com\/wp\/rabeprazole\/\"><strong>Rabeprazole<\/strong><\/a><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u00f4\u0301c \u01b0\u0301c ch\u00ea\u0301 b\u01a1m Proton. Thu\u1ed1c gi\u1ea3m ti\u1ebft acid d\u1ea1 d\u00e0y<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): A02B C04.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em><\/strong> <a href=\"https:\/\/pharmog.com\/wp\/rabeprazole-pariet\/\">Pariet<\/a>, <a href=\"https:\/\/pharmog.com\/wp\/rabeprazole-rabeloc-iv\/\">Rabeloc IV<\/a><\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c:<\/em><\/strong> Rabera , Rab-ulcer<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: C\u00f4ng ty c\u1ed5 ph\u1ea7n D\u01b0\u1ee3c ph\u1ea9m OPV<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng: <\/strong><\/p>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>Vi\u00ean n\u00e9n 10 mg, 20 mg.<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>RABERA 10<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean n\u00e9n c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Rabeprazole<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"251\" height=\"338\" class=\"wp-image-30662\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/04\/word-image-195.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/04\/word-image-195.png 251w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/04\/word-image-195-223x300.png 223w\" sizes=\"auto, (max-width: 251px) 100vw, 251px\" \/><\/p>\n<p><strong>3. Video by Pharmog:<\/strong><\/p>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe loading=\"lazy\" title=\"[Pharmog SS1 - T\u1eadp 15] - D\u01b0\u1ee3c l\u00fd c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb vi\u00eam lo\u00e9t d\u1ea1 d\u00e0y t\u00e1 tr\u00e0ng\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/wgt47Xu6X-4?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<p><strong>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng: <\/strong><\/p>\n<p><strong>4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>Lo\u00e9t t\u00e1 tr\u00e0ng c\u1ea5p t\u00ednh.<\/p>\n<p>Lo\u00e9t d\u1ea1 d\u00e0y l\u00e0nh t\u00ednh c\u1ea5p t\u00ednh.<\/p>\n<p>H\u1ed9i ch\u1ee9ng tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y \u2013 th\u1ef1c qu\u1ea3n c\u00f3 ho\u1eb7c kh\u00f4ng c\u00f3 vi\u00eam th\u1ef1c qu\u1ea3n, lo\u00e9t ho\u1eb7c tr\u1ea7y x\u01b0\u1edbc.<\/p>\n<p>H\u1ed9i ch\u1ee9ng Zollinger \u2013 Ellison.<\/p>\n<p>Lo\u00e9t h\u00e0nh t\u00e1 tr\u00e0ng v\u00e0 lo\u00e9t d\u1ea1 d\u00e0y l\u00e0nh t\u00ednh: K\u1ebft h\u1ee3p v\u1edbi li\u1ec7u tr\u00ecnh kh\u00e1ng sinh th\u00edch h\u1ee3p \u0111\u1ec3 di\u1ec7t Helicobacter pylori.<\/p>\n<p><strong>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/strong><\/p>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p>U\u1ed1ng nguy\u00ean vi\u00ean thu\u1ed1c, kh\u00f4ng nhai ho\u1eb7c b\u1ebb vi\u00ean.<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p><em>Ng\u01b0\u1eddi l\u1edbn:<\/em><\/p>\n<p>B\u1ec7nh l\u00fd tr\u00e0o ng\u01b0\u1ee3c d\u1ea1 d\u00e0y-th\u1ef1c qu\u1ea3n:<\/p>\n<p>U\u1ed1ng 20 mg, ng\u00e0y 1 l\u1ea7n, trong 4-8 tu\u1ea7n.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb l\u00e2u d\u00e0i c\u00f3 th\u1ec3 l\u00ean \u0111\u1ebfn 12 th\u00e1ng, li\u1ec1u duy tr\u00ec c\u00f3 th\u1ec3 d\u00f9ng rabeprazol 10 mg ho\u1eb7c 20 mg, ng\u00e0y 1 l\u1ea7n.<\/p>\n<p>Lo\u00e9t t\u00e1 tr\u00e0ng \u0111ang ho\u1ea1t \u0111\u1ed9ng, lo\u00e9t d\u1ea1 d\u00e0y l\u00e0nh t\u00ednh \u0111ang ho\u1ea1t \u0111\u1ed9ng:<\/p>\n<p>U\u1ed1ng 20 mg, ng\u00e0y 1 l\u1ea7n, v\u00e0o bu\u1ed5i s\u00e1ng.<\/p>\n<p>H\u1ea7u h\u1ebft b\u1ec7nh nh\u00e2n lo\u00e9t t\u00e1 tr\u00e0ng \u0111ang ho\u1ea1t \u0111\u1ed9ng \u0111\u01b0\u1ee3c ch\u1eefa l\u00e0nh trong 4 tu\u1ea7n. M\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 \u0111\u00e1p \u1ee9ng v\u1edbi rabeprazol 10 mg, u\u1ed1ng ng\u00e0y 1 l\u1ea7n, v\u00e0o bu\u1ed5i s\u00e1ng.<\/p>\n<p>H\u1ea7u h\u1ebft b\u1ec7nh nh\u00e2n lo\u00e9t d\u1ea1 d\u00e0y l\u00e0nh t\u00ednh \u0111ang ho\u1ea1t \u0111\u1ed9ng \u0111\u01b0\u1ee3c ch\u1eefa l\u00e0nh trong 6 tu\u1ea7n.<\/p>\n<p>Ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c kh\u00e1ng sinh th\u00edch h\u1ee3p trong ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb vi\u00eam lo\u00e9t d\u1ea1 d\u00e0y, t\u00e1 tr\u00e0ng do vi khu\u1ea9n Helicobacter Pylori:<\/p>\n<p>Rabeprazol \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong lo\u00e9t t\u00e1 tr\u00e0ng c\u00f3 hi\u1ec7n di\u1ec7n vi khu\u1ea9n Helicobacter Pylori, trong s\u1ef1 k\u1ebft h\u1ee3p v\u1edbi kh\u00e1ng sinh th\u00edch h\u1ee3p.<\/p>\n<table>\n<tbody>\n<tr>\n<td>Rabeprazol<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>Amoxicillin<\/td>\n<td>1000 mg<\/td>\n<\/tr>\n<tr>\n<td>Clarithromycin<\/td>\n<td>500 mg<\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\">T\u1ea5t c\u1ea3 3 thu\u1ed1c n\u00e0y \u0111\u01b0\u1ee3c u\u1ed1ng 2 l\u1ea7n m\u1ed7i ng\u00e0y v\u00e0o bu\u1ed5i \u0103n s\u00e1ng v\u00e0 bu\u1ed5i \u0103n t\u1ed1i trong 7 ng\u00e0y.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>H\u1ed9i ch\u1ee9ng Zollinger-Ellison:<\/p>\n<p>Kh\u1edfi \u0111\u1ea7u, u\u1ed1ng 60 mg, ng\u00e0y 1 l\u1ea7n. Li\u1ec1u d\u00f9ng c\u00f3 th\u1ec3 thay \u0111\u1ed5i v\u00e0 th\u1eddi gian k\u00e9o d\u00e0i t\u00f9y thu\u1ed9c v\u00e0o ch\u1ec9 \u0111\u1ecbnh l\u00e2m s\u00e0ng.<\/p>\n<p>Li\u1ec1u d\u00f9ng l\u00ean \u0111\u1ebfn 100 mg, u\u1ed1ng ng\u00e0y 1 l\u1ea7n ho\u1eb7c 60 mg, u\u1ed1ng ng\u00e0y 2 l\u1ea7n \u0111\u00e3 t\u1eebng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng.<\/p>\n<p><em>Tr\u1ebb em:<\/em><\/p>\n<p>Rabeprazol kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o cho tr\u1ebb em, b\u1edfi v\u00ec ch\u01b0a c\u00f3 kinh nghi\u1ec7m d\u00f9ng thu\u1ed1c cho nh\u00f3m n\u00e0y.<\/p>\n<p><strong>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>Qu\u00e1 m\u1eabn v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p>Ph\u1ee5 n\u1eef mang thai ho\u1eb7c \u0111ang cho con b\u00fa.<\/p>\n<p><strong>4.4 Th\u1eadn tr\u1ecdng:<\/strong><\/p>\n<p>\u0110\u00e1p \u1ee9ng tri\u1ec7u ch\u1ee9ng v\u1edbi \u0111i\u1ec1u tr\u1ecb rabeprazol kh\u00f4ng lo\u1ea1i tr\u1eeb \u0111\u01b0\u1ee3c c\u00e1c u \u00e1c t\u00ednh d\u1ea1 d\u00e0y ho\u1eb7c th\u1ef1c qu\u1ea3n \u0111\u00e3 c\u00f3; v\u00ec v\u1eady, c\u1ea7n ph\u1ea3i lo\u1ea1i tr\u1eeb kh\u1ea3 n\u0103ng b\u1ec7nh nh\u00e2n b\u1ecb u \u00e1c t\u00ednh tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng rabeprazol.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb k\u00e9o d\u00e0i v\u1edbi rabeprazol (\u0111\u1eb7c bi\u1ec7t l\u00e0 b\u1ec7nh nh\u00e2n d\u01b0\u1ee3c di\u1ec1u tr\u1ecb h\u01a1n 1 n\u0103m) c\u1ea7n \u0111\u01b0\u1ee3c gi\u00e1m s\u00e1t \u0111\u1ecbnh k\u1ef3.<\/p>\n<p>Nguy c\u01a1 ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn ch\u00e9o v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton kh\u00e1c ho\u1eb7c c\u00e1c d\u1eabn ch\u1ea5t benzimldazol khi d\u00f9ng thay th\u1ebf l\u00e0 kh\u00f4ng th\u1ec3 lo\u1ea1i tr\u1eeb.<\/p>\n<p>Kh\u00f4ng d\u00f9ng rabeprazol cho tr\u1ebb em v\u00ec ch\u01b0a c\u00f3 kinh nghi\u1ec7m s\u1eed d\u1ee5ng.<\/p>\n<p>\u0110\u00e3 c\u00f3 c\u00e1c b\u00e1o c\u00e1o h\u1eadu m\u1ea1i v\u1ec1 r\u1ed1i lo\u1ea1n t\u1ea1o m\u00e1u (gi\u1ea3m ti\u1ec3u c\u1ea7u v\u00e0 gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh). Trong \u0111a s\u1ed1 c\u00e1c tr\u01b0\u1eddng h\u1ee3p kh\u00f4ng t\u00ecm ra b\u1ec7nh c\u0103n, c\u00e1c r\u1ed1i lo\u1ea1n n\u00e0y kh\u00f4ng nghi\u00eam tr\u1ecdng v\u00e0 s\u1ebd h\u1ebft khi ng\u01b0ng rabeprazol.<\/p>\n<p>\u0110\u00e3 c\u00f3 b\u00e1o c\u00e1o b\u1ea5t th\u01b0\u1eddng enzym gan trong th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u00e0 sau khi s\u1eed d\u1ee5ng. Trong \u0111a s\u1ed1 c\u00e1c tr\u01b0\u1eddng h\u1ee3p kh\u00f4ng t\u00ecm ra b\u1ec7nh c\u0103n, c\u00e1c r\u1ed1i lo\u1ea1n n\u00e0y kh\u00f4ng nghi\u00eam tr\u1ecdng v\u00e0 s\u1ebd h\u1ebft khi ng\u01b0ng rabeprazol. Trong nghi\u00ean c\u1ee9u c\u00f3 ki\u1ec3m so\u00e1t \u1edf b\u1ec7nh nh\u00e2n suy gan t\u1eeb nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh so v\u1edbi ng\u01b0\u1eddi l\u00e0nh c\u00f9ng \u0111\u1ed9 tu\u1ed5i v\u00e0 gi\u1edbi t\u00ednh ch\u01b0a th\u1ea5y c\u00e1c v\u1ea5n \u0111\u1ec1 li\u00ean quan \u0111\u1ebfn \u0111\u1ed9 an to\u00e0n c\u1ee7a thu\u1ed1c. Tuy nhi\u00ean, do ch\u01b0a c\u00f3 c\u00e1c d\u1eef li\u1ec7u l\u00e2m s\u00e0ng v\u1ec1 s\u1eed d\u1ee5ng rabeprazol \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb nh\u1eefng ng\u01b0\u1eddi suy gan n\u1eb7ng, c\u1ea7n h\u1ebft s\u1ee9c th\u1eadn tr\u1ecdng khi ch\u1ec9 \u0111\u1ecbnh rabeprazol l\u1ea7n \u0111\u1ea7u cho c\u00e1c b\u1ec7nh nh\u00e2n n\u00e0y.<\/p>\n<p>Kh\u00f4ng d\u01b0\u1ee3c d\u00f9ng k\u1ebft h\u1ee3p rabeprazol v\u1edbi atazanavir.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton, k\u1ec3 c\u1ea3 rabeprazol, c\u00f3 th\u1ec3 t\u0103ng nguy c\u01a1 nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng ti\u00eau h\u00f3a v\u1edbi Salmonella, Campylobacter v\u00e0 Clostridium difficile.<\/p>\n<p>C\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton, \u0111\u1eb7c bi\u1ec7t n\u1ebfu d\u00f9ng li\u1ec1u cao v\u00e0 k\u00e9o d\u00e0i (tr\u00ean 1 n\u0103m) c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nh\u1eb9 nguy c\u01a1 g\u00e3y x\u01b0\u01a1ng \u1edf h\u00f4ng, c\u1ed5 tay, ho\u1eb7c c\u1ed9t s\u1ed1ng, ch\u1ee7 y\u1ebfu \u1edf ng\u01b0\u1eddi gi\u00e0 hay nh\u1eefng ng\u01b0\u1eddi c\u00f3 y\u1ebfu t\u1ed1 nguy c\u01a1. Nghi\u00ean c\u1ee9u quan s\u00e1t cho th\u1ea5y thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 chung c\u1ee7a g\u00e3y x\u01b0\u01a1ng kho\u1ea3ng 10 &#8211; 40%. M\u1ed9t s\u1ed1 trong \u0111\u00f3 c\u00f3 th\u1ec3 do c\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1 kh\u00e1c. N\u00ean ch\u0103m s\u00f3c b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 lo\u00e3ng x\u01b0\u01a1ng theo h\u01b0\u1edbng d\u1eabn l\u00e2m s\u00e0ng hi\u1ec7n h\u00e0nh v\u00e0 h\u1ecd c\u1ea7n ph\u1ea3i c\u00f3 m\u1ed9t l\u01b0\u1ee3ng vitamin D v\u00e0 canxi v\u1eeba \u0111\u1ee7.<\/p>\n<p>H\u1ea1 magnesi huy\u1ebft, c\u00f3 tri\u1ec7u ch\u1ee9ng v\u00e0 kh\u00f4ng c\u00f3 tri\u1ec7u ch\u1ee9ng \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o hi\u1ebfm g\u1eb7p \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton \u00edt nh\u1ea5t trong 3 th\u00e1ng, \u1edf h\u1ea7u h\u1ebft c\u00e1c tr\u01b0\u1eddng h\u1ee3p l\u00e0 sau m\u1ed9t n\u0103m \u0111i\u1ec1u tr\u1ecb. C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng bao g\u1ed3m co c\u1ee9ng c\u01a1, lo\u1ea1n nh\u1ecbp tim, v\u00e0 co gi\u1eadt, \u1edf h\u1ea7u h\u1ebft c\u00e1c b\u1ec7nh nh\u00e2n, di\u1ec1u tr\u1ecb h\u1ea1 magnesi huy\u1ebft y\u00eau c\u1ea7u thay th\u1ebf magnesi v\u00e0 ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton. B\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb k\u00e9o d\u00e0i ho\u1eb7c d\u00f9ng c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton v\u1edbi digoxin ho\u1eb7c c\u00e1c thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y ra h\u1ea1 magnesi huy\u1ebft (v\u00ed d\u1ee5: thu\u1ed1c l\u1ee3i ti\u1ec3u) c\u1ea7n theo d\u00f5i n\u1ed3ng \u0111\u1ed9 magnesi tr\u01b0\u1edbc v\u00e0 \u0111\u1ecbnh k\u1ef3 khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton.<\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>Thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y nh\u1ee9c \u0111\u1ea7u, ch\u00f3ng m\u1eb7t. V\u00ec v\u1eady, th\u1eadn tr\u1ecdng khi \u0111ang l\u00e1i xe ho\u1eb7c v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/strong><\/p>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: B1<\/p>\n<p>US FDA pregnancy category: NA<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh v\u1edbi ph\u1ee5 n\u1eef mang thai.<\/p>\n<p>Ch\u01b0a c\u00f3 d\u1eef li\u1ec7u nghi\u00ean c\u1ee9u v\u1ec1 \u0111\u1ed9 an to\u00e0n c\u1ee7a rabeprazol \u0111\u1ed1i v\u1edbi ph\u1ee5 n\u1eef c\u00f3 thai. Nghi\u00ean c\u1ee9u v\u1ec1 sinh s\u1ea3n tr\u00ean chu\u1ed9t v\u00e0 th\u1ecf ch\u01b0a th\u1ea5y b\u1ea5t k\u1ef3 ch\u1ee9ng c\u1ee9 n\u00e0o v\u1ec1 suy gi\u1ea3m kh\u1ea3 n\u0103ng sinh s\u1ea3n ho\u1eb7c g\u00e2y h\u1ea1i cho b\u00e0o thai do rabeprazol m\u1eb7c d\u00f9 \u1edf chu\u1ed9t rabeprazol qua nhau thai sang b\u00e0o thai \u1edf m\u1ee9c \u0111\u1ed9 th\u1ea5p.<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh v\u1edbi b\u00e0 m\u1eb9 trong th\u1eddi k\u1ef3 cho con b\u00fa.<\/p>\n<p>Ch\u01b0a bi\u1ebft rabeprazol c\u00f3 v\u00e0o s\u1eefa hay kh\u00f4ng. Ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u n\u00e0o \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh tr\u00ean c\u00e1c b\u00e0 m\u1eb9 cho con b\u00fa. Tuy nhi\u00ean, rabeprazol \u0111\u01b0\u1ee3c ti\u1ebft v\u00e0o s\u1eefa chu\u1ed9t<\/p>\n<p><strong>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/strong><\/p>\n<p><em>Th\u01b0\u1eddng g\u1eb7p, 1\/100 &lt; ADR &lt; 1\/10<\/em><\/p>\n<p>Nhi\u1ec5m khu\u1ea9n v\u00e0 nhi\u1ec5m k\u00fd sinh tr\u00f9ng: Nhi\u1ec5m khu\u1ea9n<\/p>\n<p>T\u00e2m th\u1ea7n: M\u1ea5t ng\u1ee7<\/p>\n<p>H\u1ec7 th\u1ea7n kinh: \u0110au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t<\/p>\n<p>H\u00f4 h\u1ea5p: Ho, vi\u00eam h\u1ecdng, vi\u00eam m\u0169i<\/p>\n<p>Ti\u00eau h\u00f3a: Ti\u00eau ch\u1ea3y, n\u00f4n, bu\u1ed3n n\u00f4n, \u0111au v\u00f9ng b\u1ee5ng, t\u00e1o b\u00f3n, \u0111\u1ea7y h\u01a1i<\/p>\n<p>C\u01a1 x\u01b0\u01a1ng kh\u1edbp v\u00e0 m\u00f4 li\u00ean k\u1ebft: \u0110au kh\u00f4ng r\u00f5 nguy\u00ean nh\u00e2n, \u0111au l\u01b0ng<\/p>\n<p>To\u00e0n th\u00e2n: Suy nh\u01b0\u1ee3c, c\u00e1c tri\u1ec7u ch\u1ee9ng gi\u1ed1ng c\u00fam.<\/p>\n<p><em>\u00edt g\u1eb7p, 1\/1000 &lt; ADR &lt; 1\/100<\/em><\/p>\n<p>T\u00e2m th\u1ea7n: B\u1ed3n ch\u1ed3n<\/p>\n<p>H\u1ec7 th\u1ea7n kinh: Bu\u1ed3n ng\u1ee7<\/p>\n<p>H\u00f4 h\u1ea5p: Vi\u00eam ph\u1ebf qu\u1ea3n, vi\u00eam xoang<\/p>\n<p>Ti\u00eau h\u00f3a: Kh\u00f3 ti\u00eau, kh\u00f4 mi\u1ec7ng, \u1ee3 h\u01a1i<\/p>\n<p>Da v\u00e0 m\u00f4 d\u01b0\u1edbi da: Ng\u1ee9a, h\u1ed3ng ban<\/p>\n<p>C\u01a1 x\u01b0\u01a1ng kh\u1edbp v\u00e0 m\u00f4 li\u00ean k\u1ebft: \u0110au c\u01a1, chu\u1ed9t r\u00fat, \u0111au kh\u1edbp, g\u00e3y x\u01b0\u01a1ng \u1edf h\u00f4ng, c\u1ed5 tay, ho\u1eb7c c\u1ed9t s\u1ed1ng<\/p>\n<p>Th\u1eadn v\u00e0 ti\u1ebft ni\u1ec7u: Nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng ni\u1ec7u<\/p>\n<p>To\u00e0n th\u00e2n: \u0110au ng\u1ef1c, \u1edbn l\u1ea1nh, s\u1ed1t<\/p>\n<p>Kh\u00e1c: T\u0103ng enzym gan.<\/p>\n<p><em>Hi\u1ebfm g\u1eb7p, 1\/10000 &lt; ADR &lt; 1\/1000<\/em><\/p>\n<p>M\u00e1u v\u00e0 h\u1ec7 b\u1ea1ch huy\u1ebft: Gi\u1ea3m b\u1ea1ch c\u1ea7u \u0111a nh\u00e2n trung t\u00ednh, gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m ti\u1ec3u c\u1ea7u, t\u0103ng b\u1ea1ch c\u1ea7u<\/p>\n<p>H\u1ec7 mi\u1ec5n d\u1ecbch: Qu\u00e1 m\u1eabn<\/p>\n<p>Chuy\u1ec3n h\u00f3a v\u00e0 dinh d\u01b0\u1ee1ng: Ch\u00e1n \u0103n<\/p>\n<p>T\u00e2m th\u1ea7n: Tr\u1ea7m c\u1ea3m<\/p>\n<p>M\u1eaft: R\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c<\/p>\n<p>Ti\u00eau h\u00f3a: vi\u00eam d\u1ea1 d\u00e0y, vi\u00eam mi\u1ec7ng, r\u1ed1i lo\u1ea1n v\u1ecb gi\u00e1c<\/p>\n<p>Gan m\u1eadt: Vi\u00eam gan, v\u00e0ng da, b\u1ec7nh n\u00e3o do gan<\/p>\n<p>Da v\u00e0 m\u00f4 d\u01b0\u1edbi da: Ng\u1ee9a, d\u1ed5 m\u1ed3 h\u00f4i, ph\u1ea3n \u1ee9ng ph\u1ed3ng n\u01b0\u1edbc<\/p>\n<p>Th\u1eadn v\u00e0 ti\u1ebft ni\u1ec7u: Vi\u00eam th\u1eadn k\u1ebd<\/p>\n<p>Kh\u00e1c: T\u0103ng c\u00e2n.<\/p>\n<p><em>R\u1ea5t hi\u1ebfm g\u1eb7p, ADR &lt; 1\/10000<\/em><\/p>\n<p>Da v\u00e0 m\u00f4 d\u01b0\u1edbi da: H\u1ed3ng ban \u0111a d\u1ea1ng, ho\u1ea1i t\u1eed bi\u1ec3u b\u00ec nhi\u1ec5m \u0111\u1ed9c, h\u1ed9i ch\u1ee9ng Stevens &#8211; Johnson.<\/p>\n<p><em>Ch\u01b0a bi\u1ebft t\u1ef7 l\u1ec7:<\/em><\/p>\n<p>Chuy\u1ec3n h\u00f3a v\u00e0 dinh d\u01b0\u1ee1ng: H\u1ea1 natri huy\u1ebft, h\u1ea1 magnesi huy\u1ebft<\/p>\n<p>T\u00e2m th\u1ea7n: L\u00fa l\u1eabn<\/p>\n<p>M\u1ea1ch: Ph\u00f9 ngo\u1ea1i bi\u00ean<\/p>\n<p>H\u1ec7 sinh s\u1ea3n v\u00e0 tuy\u1ebfn v\u00fa: Ch\u1ee9ng v\u00fa to \u1edf \u0111\u00e0n \u00f4ng.<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<p><strong>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/strong><\/p>\n<p>Ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c. V\u1edbi c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i nh\u1eb9, th\u01b0\u1eddng ch\u1ec9 c\u1ea7n ng\u1eebng thu\u1ed1c. Tr\u01b0\u1eddng h\u1ee3p m\u1eabn c\u1ea3m n\u1eb7ng ho\u1eb7c ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, c\u1ea7n ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 (gi\u1eef tho\u00e1ng kh\u00ed v\u00e0 d\u00f9ng epinephrin, th\u1edf oxygen, d\u00f9ng kh\u00e1ng histamin, corticoid&#8230;).<\/p>\n<p><strong>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/strong><\/p>\n<p>Rabeprazol c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m h\u1ea5p thu c\u1ee7a c\u00e1c thu\u1ed1c m\u00e0 pH d\u1ea1 d\u00e0y l\u00e0m t\u0103ng sinh kh\u1ea3 d\u1ee5ng c\u1ee7a ch\u00fang (ketoconazol, itraconazol, ampicillin ester v\u00e0 mu\u1ed1i s\u1eaft)<\/p>\n<p>D\u00f9ng \u0111\u1ed3ng th\u1eddi rabeprazol l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 c\u1ee7a digoxin.<\/p>\n<p>Atazanavir: D\u00f9ng d\u1ed3ng th\u1eddi atazanavir 300 mg\/ritonavlr 100 mg c\u00f9ng v\u1edbi Omeprazol (40 mg 1 l\u1ea7n\/ng\u00e0y) hay atazanavir 400 mg v\u1edbi lansoprazol (60 mg 1 l\u1ea7n\/ng\u00e0y) tr\u00ean ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n kh\u1ecfe m\u1ea1nh cho th\u1ea5y gi\u1ea3m m\u1ea1nh n\u1ed3ng \u0111\u1ed9 atazanavir. S\u1ef1 h\u1ea5p thu atazanavlr ph\u1ee5 thu\u1ed9c v\u00e0o pH. M\u1eb7c d\u00f9 ch\u01b0a d\u01b0\u1ee3c nghi\u00ean c\u1ee9u, c\u00e1c hi\u1ec7n t\u01b0\u1ee3ng tr\u00ean c\u0169ng x\u1ea3y ra v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton kh\u00e1c. V\u00ec v\u1eady, kh\u00f4ng n\u00ean d\u00f9ng \u0111\u1ed3ng th\u1eddi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton, bao g\u1ed3m rabeprazol v\u1edbi atazanavir.<\/p>\n<p>Warfarin: T\u0103ng INR v\u00e0 th\u1eddi gian prothrombin \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n d\u00f9ng \u0111\u1ed3ng th\u1eddi warfarin v\u1edbi m\u1ed9t thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton, bao g\u1ed3m rabeprazol. B\u1edfi v\u00ec t\u0103ng nh\u01b0 v\u1eady c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn xu\u1ea5t huy\u1ebft b\u1ea5t th\u01b0\u1eddng v\u00e0 t\u1eed vong, theo d\u00f5i INR v\u00e0 th\u1eddi gian prothrombin c\u00f3 th\u1ec3 c\u1ea7n thi\u1ebft trong qu\u00e1 trinh s\u1eed d\u1ee5ng d\u1ed3ng th\u1eddi v\u1edbi rabeprazol.<\/p>\n<p>Sucralfat: T\u01b0\u01a1ng t\u00e1c d\u01b0\u1ee3c d\u1ed9ng h\u1ecdc ti\u1ec1m n\u0103ng. D\u00f9ng d\u1ed3ng th\u1eddi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton v\u1edbi sucraltat d\u1eabn \u0111\u1ebfn s\u1ef1 h\u1ea5p thu ch\u1eadm v\u00e0 gi\u1ea3m sinh kh\u1ea3 d\u1ee5ng c\u1ee7a c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton n\u00e0y. D\u00f9ng c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton \u00edt nh\u1ea5t 30 ph\u00fat tr\u01b0\u1edbc khi d\u00f9ng sucraltat.<\/p>\n<p>Methotrexat: Trong c\u00e1c b\u00e1o c\u00e1o, c\u00e1c nghi\u00ean c\u1ee9u d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc v\u1ec1 d\u00e2n s\u1ed1 \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 v\u00e0 ph\u00e2n t\u00edch h\u1ed3i c\u1ee9u cho th\u1ea5y r\u1eb1ng d\u00f9ng \u0111\u1ed3ng th\u1eddi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton v\u00e0 methotrexat (ch\u1ee7 y\u1ebfu \u1edf li\u1ec1u cao) c\u00f3 th\u1ec3 l\u00e0m t\u0103ng v\u00e0 duy tr\u00ec n\u1ed3ng d\u1ed9 methotrexat trong huy\u1ebft thanh v\u00e0\/ho\u1eb7c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a n\u00f3 l\u00e0 hydroxymethotrexat. Tuy nhi\u00ean, ch\u01b0a c\u00f3 c\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 t\u01b0\u01a1ng t\u00e1c thu\u1ed1c ch\u00ednh th\u1ee9c c\u1ee7a methotrexat v\u1edbi c\u00e1c PPI \u0111\u00e3 d\u01b0\u1ee3c ti\u1ebfn h\u00e0nh.<\/p>\n<p><strong>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/strong><\/p>\n<p>Kh\u00f4ng c\u00f3 kinh nghi\u1ec7m qu\u00e1 li\u1ec1u rabeprazol. Li\u1ec1u t\u1ed1i \u0111a \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o l\u00e0 80 mg. Kh\u00f4ng c\u00f3 d\u1ea5u hi\u1ec7u v\u00e0 tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng n\u00e0o li\u00ean quan \u0111\u1ebfn qu\u00e1 li\u1ec1u. Trong khi b\u1ec7nh nh\u00e2n h\u1ed9i ch\u1ee9ng Zollinger-Ellison \u0111\u00e3 t\u1eebng \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb l\u00ean \u0111\u1ebfn 120 mg rabeprazol ng\u00e0y 1 l\u1ea7n. Kh\u00f4ng c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u n\u00e0o \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn. Rabeprazol li\u00ean k\u1ebft m\u1ea1nh v\u1edbi protein v\u00e0 kh\u00f4ng th\u1ec3 th\u1ea9m t\u00e1ch d\u1ec5 d\u00e0ng. Trong tr\u01b0\u1eddng h\u1ee3p qu\u00e1 li\u1ec1u, n\u00ean \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng v\u00e0 h\u1ed7 tr\u1ee3.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/strong><\/p>\n<p><strong>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/strong><\/p>\n<p>Rabeprazol \u1ee9c ch\u1ebf s\u1ef1 b\u00e0i ti\u1ebft acid c\u1ee7a d\u1ea1 d\u00e0y do \u1ee9c ch\u1ebf c\u00f3 h\u1ed3i ph\u1ee5c men H+\/K+ adenosin triphosphatase (b\u01a1m proton) \u1edf t\u1ebf b\u00e0o th\u00e0nh d\u1ea1 d\u00e0y<\/p>\n<p>Sau khi u\u1ed1ng 20 mg rabeprazol, t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf ti\u1ebft acid d\u1ecbch v\u1ecb s\u1ebd xu\u1ea5t hi\u1ec7n trong v\u00f2ng 1 gi\u1edd, t\u00e1c d\u1ee5ng t\u1ed1i \u0111a trong v\u00f2ng 2-4 gi\u1edd. T\u1ef7 l\u1ec7 \u1ee9c ch\u1ebf ti\u1ebft acid c\u01a1 b\u1ea3n v\u00e0 ti\u1ebft acid do th\u1ee9c \u0103n k\u00edch th\u00edch t\u1ea1i th\u1eddi \u0111i\u1ec3m 23 gi\u1edd sau khi u\u1ed1ng li\u1ec1u \u0111\u1ea7u ti\u00ean c\u1ee7a rabeprazol t\u01b0\u01a1ng \u1ee9ng l\u00e0 69% v\u00e0 82%. Th\u1eddi gian \u1ee9c ch\u1ebf c\u00f3 th\u1ec3 k\u00e9o d\u00e0i \u0111\u1ebfn 48 gi\u1edd. T\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf ti\u1ebft acid c\u1ee7a rabeprazol t\u0103ng nh\u1eb9 v\u1edbi li\u1ec1u l\u1eb7p l\u1ea1i h\u00e0ng ng\u00e0y 1 l\u1ea7n v\u00e0 \u0111\u1ea1t m\u1ee9c \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh sau 3 ng\u00e0y d\u00f9ng thu\u1ed1c. S\u1ef1 ti\u1ebft acid tr\u1edf n\u00ean b\u00ecnh th\u01b0\u1eddng sau 2 &#8211; 3 ng\u00e0y ng\u1eebng thu\u1ed1c.<\/p>\n<p>\u1ede c\u00e1c b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng rabeprazol 10 &#8211; 20 mg h\u00e0ng ng\u00e0y trong th\u1eddi gian k\u00e9o d\u00e0i \u0111\u1ebfn 43 th\u00e1ng, n\u1ed3ng \u0111\u1ed9 gastrin huy\u1ebft thanh t\u0103ng trong 2-8 tu\u1ea7n \u0111\u1ea7u ti\u00ean cho th\u1ea5y rabeprazol c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf ti\u1ebft acid v\u00e0 n\u1ed3ng \u0111\u1ed9 gastrin duy tr\u00ec \u1ed5n \u0111\u1ecbnh n\u1ebfu \u0111i\u1ec1u tr\u1ecb ti\u1ebfp t\u1ee5c. N\u1ed3ng \u0111\u1ed9 gastrin huy\u1ebft t\u01b0\u01a1ng s\u1ebd tr\u1edf l\u1ea1i gi\u00e1 tr\u1ecb tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb trong v\u00f2ng 1 &#8211; 2 tu\u1ea7n sau khi ng\u01b0ng thu\u1ed1c<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>Rabeprazole sodium thu\u1ed9c nh\u00f3m thu\u1ed1c kh\u00e1ng ti\u1ebft acid, nh\u1eefng d\u1eabn xu\u1ea5t c\u1ee7a benzimidazoles th\u1ebf, kh\u00f4ng c\u00f3 \u0111\u1eb7c t\u00ednh kh\u00e1ng ti\u1ebft cholin hay \u0111\u1ed1i kh\u00e1ng histamine H<sub>2<\/sub>\u00a0nh\u01b0ng \u1ee9c ch\u1ebf s\u1ef1 ti\u1ebft acid \u1edf d\u1ea1 d\u00e0y b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf chuy\u00ean bi\u1ec7t enzyme H+\/K+ &#8211; ATPase (b\u01a1m acid hay b\u01a1m proton). Hi\u1ec7u qu\u1ea3 t\u1ef7 l\u1ec7 v\u1edbi li\u1ec1u l\u01b0\u1ee3ng v\u00e0 \u1ee9c ch\u1ebf c\u1ea3 s\u1ef1 ti\u1ebft acid c\u01a1 b\u1ea3n l\u1eabn s\u1ef1 ti\u1ebft acid do k\u00edch th\u00edch b\u1ea5t k\u1ec3 t\u00e1c nh\u00e2n k\u00edch th\u00edch n\u00e0o. Nh\u1eefng nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y sau khi u\u1ed1ng, rabeprazole sodium nhanh ch\u00f3ng bi\u1ebfn m\u1ea5t kh\u1ecfi huy\u1ebft t\u01b0\u01a1ng v\u00e0 ni\u00eam m\u1ea1c d\u1ea1 d\u00e0y. V\u00ec l\u00e0 m\u1ed9t base y\u1ebfu, rabeprazole nhanh ch\u00f3ng \u0111\u01b0\u1ee3c h\u1ea5p thu d\u00f9 \u1edf li\u1ec1u l\u01b0\u1ee3ng n\u00e0o v\u00e0 t\u1eadp trung v\u00e0o m\u00f4i tr\u01b0\u1eddng acid c\u1ee7a t\u1ebf b\u00e0o th\u00e0nh. Rabeprazole \u0111\u01b0\u1ee3c chuy\u1ec3n th\u00e0nh d\u1ea1ng sulphenamide c\u00f3 ho\u1ea1t t\u00ednh qua s\u1ef1 proton h\u00f3a v\u00e0 sau \u0111\u00f3 ph\u1ea3n \u1ee9ng v\u1edbi cysteines c\u00f3 s\u1eb5n \u1edf b\u01a1m proton.<\/p>\n<p><a href=\"https:\/\/www.youtube.com\/watch?v=wgt47Xu6X-4\"><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/a><\/p>\n<p><strong>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/strong><\/p>\n<p><em>H\u1ea5p thu:<\/em> Rabeprazol h\u1ea5p thu r\u1ea5t nhanh v\u00e0 n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng xu\u1ea5t hi\u1ec7n \u1edf 3,5 gi\u1edd sau khi u\u1ed1ng thu\u1ed1c, sinh kh\u1ea3 d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng kho\u1ea3ng 52% \u0111\u1ed1i v\u1edbi vi\u00ean n\u00e9n bao tan trong ru\u1ed9t do b\u1ecb chuy\u1ec3n h\u00f3a qua v\u00f2ng tu\u1ea7n ho\u00e0n \u0111\u1ea7u v\u00e0 kh\u00f4ng thay \u0111\u1ed5i nhi\u1ec1u khi d\u00f9ng li\u1ec1u m\u1ed9t l\u1ea7n hay li\u1ec1u l\u1eb7p l\u1ea1i.<\/p>\n<p>Khi d\u00f9ng rabeprazol c\u00f9ng v\u1edbi b\u1eefa \u0103n nhi\u1ec1u ch\u1ea5t b\u00e9o, Tmax kh\u00e1c nhau v\u00e0 c\u00f3 th\u1ec3 l\u00e0m ch\u1eadm s\u1ef1 h\u1ea5p thu l\u00ean t\u1edbi 4 gi\u1edd ho\u1eb7c l\u00e2u h\u01a1n. Tuy nhi\u00ean, cmax v\u00e0 m\u1ee9c \u0111\u1ed9 h\u1ea5p thu c\u1ee7a rabeprazol (AUC) thay \u0111\u1ed5i kh\u00f4ng \u0111\u00e1ng k\u1ec3. Nh\u01b0 v\u1eady, c\u00f3 th\u1ec3 u\u1ed1ng rabeprazol m\u00e0 kh\u00f4ng c\u1ea7n quan t\u00e2m \u0111\u1ebfn b\u1eefa \u0103n.<\/p>\n<p><em>Ph\u00e2n b\u1ed1:<\/em> Rabeprazol g\u1eafn g\u1ea7n 97% v\u1edbi c\u00e1c protein huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<p><em>Chuy\u1ec3n h\u00f3a:<\/em> In vitro rabeprazol chuy\u1ec3n h\u00f3a trong gan b\u1edfi c\u00e1c isoenzym cytochrom P450 (CYP2C19 v\u00e0 CYP3A4) th\u00e0nh c\u00e1c d\u1eabn ch\u1ea5t thioeter, thioeter c\u1ee7a acid carboxylic, sulton v\u00e0 desmethylthioeter. \u1edf n\u1ed3ng \u0111\u1ed9 huy\u1ebft t\u01b0\u01a1ng th\u1eed nghi\u1ec7m, rabeprazol kh\u00f4ng g\u00e2y c\u1ea3m \u1ee9ng ho\u1eb7c \u1ee9c ch\u1ebf CYP3A4.<\/p>\n<p>Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a rabeprazol trong huy\u1ebft t\u01b0\u01a1ng kho\u1ea3ng 1 gi\u1edd, t\u0103ng t\u1eeb 2 \u0111\u1ebfn 3 l\u1ea7n \u1edf b\u1ec7nh nh\u00e2n suy gan, 1,6 l\u1ea7n \u1edf nh\u1eefng ng\u01b0\u1eddi enzym CYP2C19 chuy\u1ec3n h\u00f3a ch\u1eadm v\u00e0 t\u0103ng 30% \u1edf ng\u01b0\u1eddi gi\u00e0.<\/p>\n<p><em>Th\u1ea3i tr\u1eeb:<\/em> C\u00e1c d\u1eabn ch\u1ea5t chuy\u1ec3n h\u00f3a d\u01b0\u1ee3c th\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu qua n\u01b0\u1edbc ti\u1ec3u (g\u1ea7n 90%), ph\u1ea7n c\u00f2n l\u1ea1i th\u1ea3i tr\u1eeb qua ph\u00e2n.<\/p>\n<p>N\u1ed3ng \u0111\u1ed9 rabeprazol trong huy\u1ebft t\u01b0\u01a1ng t\u0103ng \u1edf ng\u01b0\u1eddi cao tu\u1ed5i v\u00e0 \u1edf ng\u01b0\u1eddi b\u1ecb b\u1ec7nh gan<\/p>\n<p><strong>5.3 Gi\u1ea3i th\u00edch: <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong>5.4 Thay th\u1ebf thu\u1ed1c : <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/strong><\/p>\n<p><strong>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/strong><\/p>\n<p>&#8230;.<\/p>\n<p><strong>6.2. T\u01b0\u01a1ng k\u1ef5 :<\/strong><\/p>\n<p>Kh\u00f4ng \u00e1p d\u1ee5ng.<\/p>\n<p><strong>6.3. B\u1ea3o qu\u1ea3n: <\/strong><\/p>\n<p>N\u01a1i kh\u00f4, tr\u00e1nh \u00e1nh s\u00e1ng, nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30\u00b0C.<\/p>\n<p><strong>6.4. Th\u00f4ng tin kh\u00e1c :<\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/strong><\/p>\n<p>D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n<p>Ho\u1eb7c HDSD Thu\u1ed1c.<\/p>\n<p><strong>7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<\/strong><\/p>\n<p>B\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c s\u01b0u t\u1ea7m ho\u1eb7c vi\u1ebft b\u1edfi: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-tac-gia-bac-sy-do-my-linh\/\">B\u00e1c s\u0129 nhi khoa &#8211; \u0110\u1ed7 M\u1ef9 Linh.<\/a><\/p>\n<p>Ki\u1ec3m duy\u1ec7t , hi\u1ec7u \u0111\u00ednh v\u00e0 \u0111\u0103ng t\u1ea3i: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-ve-pharmog-team\/\">PHARMOG TEAM<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Rabera , Rab-ulcer l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Rabera , Rab-ulcer (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;) 1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Rabeprazole Ph\u00e2n lo\u1ea1i: Thu\u00f4\u0301c [&hellip;]<\/p>\n","protected":false},"author":8612,"featured_media":30662,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[1205],"class_list":["post-30661","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-rabeprazole"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/30661","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/8612"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=30661"}],"version-history":[{"count":3,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/30661\/revisions"}],"predecessor-version":[{"id":45893,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/30661\/revisions\/45893"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/30662"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=30661"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=30661"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=30661"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}