{"id":30272,"date":"2021-04-02T16:42:02","date_gmt":"2021-04-02T09:42:02","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=30272"},"modified":"2025-01-08T08:36:53","modified_gmt":"2025-01-08T01:36:53","slug":"mometasone-eu-fastmome","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/mometasone-eu-fastmome\/","title":{"rendered":"Mometasone &#8211; Eu-Fastmome"},"content":{"rendered":"<p><em>Thu\u1ed1c Eu-Fastmome l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Eu-Fastmome (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;)<\/em><\/p>\n<p><strong>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: <\/strong><\/p>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <\/strong><a href=\"https:\/\/pharmog.com\/wp\/mometasone\/\"><strong>Mometasone<\/strong><\/a><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u1ed1c Corticosteroids.<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c tra m\u0169i \u2264 50 mcg\/l\u1ea7n x\u1ecbt v\u1edbi quy c\u00e1ch \u0111\u00f3ng g\u00f3i \u2264 200 li\u1ec1u\/h\u1ed9p v\u00e0 thu\u1ed1c d\u00f9ng ngo\u00e0i l\u00e0 thu\u1ed1c kh\u00f4ng k\u00ea \u0111\u01a1n OTC (Over the counter drugs), c\u00f2n l\u1ea1i l\u00e0 d\u1ea1ng thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): D07AC13; D07XC03, R01AD09; R03BA07.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em><\/strong> <a href=\"https:\/\/pharmog.com\/wp\/mometasone-nasonex\/\">Nasonex<\/a>, <a href=\"https:\/\/pharmog.com\/wp\/mometasone-elomet-cream\/\">Elomet Cream<\/a><\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c:<\/em><\/strong> Eu-Fastmome 50 micrograms\/actuation<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: \u00a0Mipharm S.p.A &#8211; Italy<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng:<\/strong><\/p>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>H\u1ed9p ch\u1ee9a 1 l\u1ecd 18g h\u1ed7n d\u1ecbch x\u1ecbt m\u0169i (t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 140 li\u1ec1u x\u1ecbt) (t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 50 microgam mometason furoat monohydrat m\u1ed7i l\u1ea7n x\u1ecbt).<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>EU-FASTMOME<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i l\u1ea7n x\u1ecbt c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Mometasone furoate<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>50 mcg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"521\" height=\"393\" class=\"wp-image-30273\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/04\/word-image-46.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/04\/word-image-46.png 521w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/04\/word-image-46-300x226.png 300w\" sizes=\"auto, (max-width: 521px) 100vw, 521px\" \/><\/p>\n<p><strong>3. Video by Pharmog:<\/strong><\/p>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<p><strong>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng: <\/strong><\/p>\n<p><strong>4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>EU-FASTMOME 50 micrograms\/actuation \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb c\u00e1c tri\u1ec7u ch\u1ee9ngvi\u00eam m\u0169i theo m\u00f9a v\u00e0 quanh n\u0103m \u1edf ng\u01b0\u1eddi l\u1edbn, thanh thi\u1ebfu ni\u00ean v\u00e0 tr\u1ebb em t\u1eeb 3 \u0111\u1ebfn 11 tu\u1ed5i. EU-FASTMOME 50 micrograms\/actuation \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh d\u1ef1 ph\u00f2ng cho b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed vi\u00eam m\u0169i d\u1ecb \u1ee9ng theo m\u00f9a v\u1edbi tri\u1ec7u ch\u1ee9ng v\u1eeba \u0111\u1ebfn n\u1eb7ng \u1edf ng\u01b0\u1eddi l\u1edbn v\u00e0 thanh thi\u1ebfu ni\u00ean t\u1eeb 12 tu\u1ed5i tr\u1edf l\u00ean.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb d\u1ef1 ph\u00f2ng n\u00ean \u0111\u01b0\u1ee3c b\u1eaft \u0111\u1ea7u 2-4 tu\u1ea7n tr\u01b0\u1edbc khi d\u1ef1 \u0111o\u00e1n kh\u1edfi \u0111\u1ea7u m\u00f9a ph\u1ea5n hoa. EU-FASTMOME 50 micrograms\/actuation c\u0169ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng li\u00ean quan \u0111\u1ebfn c\u00e1c kh\u1ed1i u m\u0169i bao g\u1ed3m t\u1eafc ngh\u1ebdn v\u00e0 gi\u1ea3m kh\u1ee9u gi\u00e1c \u1edf ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh t\u1eeb 18 tu\u1ed5i tr\u1edf l\u00ean.<\/p>\n<p><strong>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/strong><\/p>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p>H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng<\/p>\n<p>Nh\u1eb9 nh\u00e0ng l\u1eafc l\u1ecd v\u00e0 b\u1ecf n\u1eafp b\u1ea3o v\u1ec7 (h\u00ecnh 1)<\/p>\n<p>Nh\u1eb9 nh\u00e0ng l\u00e0m s\u1ea1ch m\u0169i c\u1ee7a b\u1ea1n.<\/p>\n<p>B\u1ecbt m\u1ed9t b\u00ean m\u0169i \u0111\u1ed3ng th\u1eddi \u0111\u01b0a v\u00f2i b\u00ecnh x\u1ecbt v\u00e0o b\u00ean l\u1ed7 m\u0169i c\u00f2n l\u1ea1i (h\u00ecnh 2). Gi\u1eef b\u00ecnh th\u1eb3ng trong khi \u0111\u1ea7u c\u1ee7a b\u1ea1n h\u01a1i nghi\u00eang nh\u1eb9 v\u1ec1 ph\u00eda tr\u01b0\u1edbc.<\/p>\n<p>B\u1eaft \u0111\u1ea7u th\u1edf ch\u1eadm v\u00e0 x\u1ecbt thu\u1ed1c v\u00e0o m\u0169i b\u1eb1ng c\u00e1ch d\u00f9ng ng\u00f3n tay . nh\u1ea5n b\u00ecnh m\u1ed9t l\u1ea7n.<\/p>\n<p>Th\u1edf ra b\u1eb1ng mi\u1ec7ng. L\u1eb7p l\u1ea1i b\u01b0\u1edbc 4 v\u00e0o l\u1ed7 m\u0169i \u0111\u00f3 1 l\u1ea7n n\u1eefa (n\u1ebfu d\u00f9ng 2 li\u1ec1u x\u1ecbt m\u1ed7i b\u00ean m\u0169i).<\/p>\n<p>B\u1ecf b\u00ecnh x\u1ecbt ra kh\u1ecfi l\u1ed7 m\u0169i v\u00e0 th\u1edf ra qua mi\u1ec7ng.<\/p>\n<p>L\u1eb7p l\u1ea1i t\u1eeb b\u01b0\u1edbc 3 \u0111\u1ebfn b\u01b0\u1edbc 6 cho l\u1ed7 m\u0169i c\u00f2n l\u1ea1i. Sau khi s\u1eed d\u1ee5ng, lau b\u00ecnh x\u1ecbt b\u1eb1ng kh\u0103n s\u1ea1ch ho\u1eb7c kh\u0103n gi\u1ea5y v\u00e0 \u0111\u00f3ng n\u1eafp.<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p>Khi s\u1eed d\u1ee5ng l\u1ea7n \u0111\u1ea7u ti\u00ean, ho\u1eb7c n\u1ebfu \u0111\u1ea7u b\u01a1m x\u1ecbt kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng tr\u00ean 14 ng\u00e0y, n\u00ean x\u1ecbt thu\u1ed1c 6 ho\u1eb7c 7 l\u1ea7n nh\u1eb1m \u0111i\u1ec1u ch\u1ec9nh b\u00ecnh x\u1ecbt cho \u0111\u1ebfn khi thu\u1ed1c x\u1ecbt ra \u0111\u1ed3ng \u0111\u1ec1u. M\u1ed7i li\u1ec1u x\u1ecbt h\u1ed7n d\u1ecbch ch\u1ee9a mometasone furoate monohydrate t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi 50 microgram mometasone furoate.<\/p>\n<p>L\u1eafc k\u1ef9 tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<\/p>\n<p><em>B\u1ec7nh vi\u00eam m\u0169i d\u1ecb \u1ee9ng theo m\u00f9a hay vi\u00eam m\u0169i quanh n\u0103m<\/em><\/p>\n<p>Ng\u01b0\u1eddi l\u1edbn (bao g\u1ed3m c\u1ea3 b\u1ec7nh nh\u00e2n cao tu\u1ed5i) v\u00e0 thanh thi\u1ebfu ni\u00ean<\/p>\n<p>Li\u1ec1u khuy\u1ebfn c\u00e1o th\u00f4ng th\u01b0\u1eddng \u0111\u1ec3 ph\u00f2ng b\u1ec7nh v\u00e0 \u0111i\u1ec1u tr\u1ecb l\u00e0 hai li\u1ec1u x\u1ecbt (50 microgram\/ li\u1ec1u x\u1ecbt) cho m\u1ed7i b\u00ean m\u0169i, 1 l\u1ea7n\/ ng\u00e0y (t\u1ed5ng li\u1ec1u 200 microgram). Khi \u0111\u00e3 ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c tri\u1ec7u ch\u1ee9ng th\u00ec gi\u1ea3m li\u1ec1u xu\u1ed1ng 1 li\u1ec1u x\u1ecbt cho m\u1ed7i b\u00ean m\u0169i (t\u1ed5ng li\u1ec1u 100 microgram) c\u00f3 th\u1ec3 c\u00f3 hi\u1ec7u qu\u1ea3 duy tr\u00ec.<\/p>\n<p>N\u1ebfu kh\u00f4ng ki\u1ec3m so\u00e1t tri\u1ec7u ch\u1ee9ng t\u1ed1t th\u00ec n\u00ean t\u0103ng \u0111\u1ebfn li\u1ec1u t\u1ed1i \u0111a m\u1ed7i ng\u00e0y l\u00e0 4 li\u1ec1u x\u1ecbt cho m\u1ed7i b\u00ean m\u0169i\/ ng\u00e0y (t\u1ed5ng li\u1ec1u 400 microgram). N\u00ean gi\u1ea3m li\u1ec1u sau khi ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c tri\u1ec7u ch\u1ee9ng.<\/p>\n<p>T\u00e1c d\u1ee5ng \u0111\u00e1ng k\u1ec3 tr\u00ean l\u00e2m s\u00e0ng xu\u1ea5t hi\u1ec7n s\u1edbm sau 12 gi\u1edd d\u00f9ng li\u1ec1u \u0111\u1ea7u ti\u00ean.<\/p>\n<p>Tr\u1ebb em t\u1eeb 3 \u0111\u1ebfn 11 tu\u1ed5i<\/p>\n<p>Li\u1ec1u khuy\u1ebfn c\u00e1o th\u00f4ng th\u01b0\u1eddng l\u00e0 1 li\u1ec1u x\u1ecbt (50 microgram) cho m\u1ed9t b\u00ean m\u0169i, 1 l\u1ea7n\/ ng\u00e0y (t\u1ed5ng li\u1ec1u 100 microgram). S\u1eed d\u1ee5ng cho tr\u1ebb em nh\u1ecf c\u1ea7n c\u00f3 s\u1ef1 ki\u1ec3m so\u00e1t c\u1ee7a ng\u01b0\u1eddi l\u1edbn.<\/p>\n<p><em>\u0110i\u1ec1u tr\u1ecb b\u1ec7nh polyp m\u0169i.<\/em><\/p>\n<p>Ng\u01b0\u1eddi l\u1edbn (k\u1ec3 c\u1ea3 ng\u01b0\u1eddi cao tu\u1ed5i) v\u00e0 thanh thi\u1ebfu ni\u00ean t\u1eeb 18 tu\u1ed5i tr\u1edf l\u00ean<\/p>\n<p>Li\u1ec1u khuy\u1ebfn c\u00e1o th\u00f4ng th\u01b0\u1eddng l\u00e0 2 li\u1ec1u x\u1ecbt (50 microgram\/1 li\u1ec1u x\u1ecbt) cho m\u1ed9t b\u00ean m\u0169i, 2 l\u1ea7n\/ ng\u00e0y (t\u1ed5ng li\u1ec1u 400 microgam).<\/p>\n<p>N\u1ebfu tri\u1ec7u ch\u1ee9ng \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t t\u1ed1t, li\u1ec1u gi\u1ea3m xu\u1ed1ng c\u00f2n 2 li\u1ec1u x\u1ecbt cho m\u1ed7i b\u00ean m\u0169i (50 microgram\/1 li\u1ec1u x\u1ecbt) 1 l\u1ea7n\/ ng\u00e0y (t\u1ed5ng li\u1ec1u 200 microgam).<\/p>\n<p><strong>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>M\u1eabn c\u1ea3m v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p>Mometasone furoate d\u1ea1ng x\u1ecbt kh\u00f4ng \u0111\u01b0\u1ee3c d\u00f9ng khi c\u00f3 c\u00e1c nhi\u1ec5m khu\u1ea9n khu tr\u00fa kh\u00f4ng \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb \u1edf ni\u00eam m\u1ea1c m\u0169i.<\/p>\n<p>Do t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf c\u1ee7a corticosteroid trong vi\u1ec7c l\u00e0m l\u00e0nh v\u1ebft th\u01b0\u01a1ng, c\u00e1c b\u1ec7nh nh\u00e2n v\u1eeba qua ph\u1eabu thu\u1eadt m\u0169i hay ch\u1ea5n th\u01b0\u01a1ng m\u0169i kh\u00f4ng \u0111\u01b0\u1ee3c d\u00f9ng corticosteroid \u0111\u01b0\u1eddng m\u0169i cho t\u1edbi khi l\u00e0nh v\u1ebft th\u01b0\u01a1ng.<\/p>\n<p><strong>4.4 Th\u1eadn tr\u1ecdng:<\/strong><\/p>\n<p>Mometasone furoate n\u00ean \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng th\u1eadn tr\u1ecdng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb nhi\u1ec5m khu\u1ea9n lao d\u1ea1ng ti\u1ec1m \u1ea9n ho\u1eb7c ho\u1ea1t \u0111\u1ed9ng, ho\u1eb7c nhi\u1ec5m virus to\u00e0n th\u00e2n, vi khu\u1ea9n, n\u1ea5m ch\u01b0a \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb ho\u1eb7c herpes simplex \u1edf m\u1eaft.<\/p>\n<p>Sau 12 th\u00e1ng \u0111i\u1ec1u tr\u1ecb v\u1edbi mometasone furoate, kh\u00f4ng c\u00f3 b\u1eb1ng ch\u1ee9ng v\u1ec1 s\u1ef1 teo \u1edf ni\u00eam m\u1ea1c m\u0169i, mometasone furoate c\u00f3 xu h\u01b0\u1edbng ph\u1ee5c h\u1ed3i ni\u00eam m\u1ea1c m\u0169i tr\u1edf v\u1ec1 ki\u1ec3u h\u00ecnh m\u00f4 h\u1ecdc b\u00ecnh th\u01b0\u1eddng.<\/p>\n<p>Khi \u0111i\u1ec1u tr\u1ecb d\u00e0i ng\u00e0y, b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng thu\u1ed1c x\u1ecbt m\u0169i mometasone furoate trong v\u00e0i th\u00e1ng ho\u1eb7c l\u00e2u h\u01a1n ph\u1ea3i \u0111\u01b0\u1ee3c ki\u1ec3m tra \u0111\u1ecbnh k\u1ef3 v\u1ec1 c\u00e1c thay \u0111\u1ed5i c\u00f3 th\u1ec3 c\u00f3 \u1edf ni\u00eam m\u1ea1c m\u0169i. N\u1ebfu xu\u1ea5t hi\u1ec7n nhi\u1ec5m n\u1ea5m khu tr\u00fa \u1edf m\u0169i ho\u1eb7c h\u1ecdng, c\u1ea7n ng\u01b0ng vi\u1ec7c d\u00f9ng thu\u1ed1c ho\u1eb7c c\u00f3 th\u1ec3 y\u00eau c\u1ea7u \u0111i\u1ec1u tr\u1ecb th\u00edch h\u1ee3p. N\u1ebfu k\u00edch \u1ee9ng m\u0169i h\u1ecdng k\u00e9o d\u00e0i c\u00f3 th\u1ec3 y\u00eau c\u1ea7u ng\u1eebng \u0111i\u1ec1u tr\u1ecb v\u1edbi mometasone furoate d\u1ea1ng x\u1ecbt.<\/p>\n<p>Kh\u00f4ng c\u00f3 b\u1eb1ng ch\u1ee9ng \u1ee9c ch\u1ebf tr\u1ee5c h\u1ea1 \u0111\u1ed3i &#8211; tuy\u1ebfn y\u00ean &#8211; th\u01b0\u1ee3ng th\u1eadn (HPA) sau khi s\u1eed d\u1ee5ng mometasone furoate k\u00e9o d\u00e0i. Tuy nhi\u00ean n\u00ean theo d\u00f5i th\u1eadn tr\u1ecdng nh\u1eefng b\u1ec7nh nh\u00e2n chuy\u1ec3n t\u1eeb s\u1eed d\u1ee5ng k\u00e9o d\u00e0i corticosteroid t\u00e1c d\u1ee5ng to\u00e0n th\u00e2n sang d\u00f9ng mometasone furoate d\u1ea1ng x\u1ecbt. \u1ede nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y, khi d\u1eebng corticosteroid to\u00e0n th\u00e2n c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn suy th\u01b0\u1ee3ng th\u1eadn trong nhi\u1ec1u th\u00e1ng cho \u0111\u1ebfn khi ch\u1ee9c n\u0103ng tr\u1ee5c HPA ph\u1ee5c h\u1ed3i. N\u00ean d\u00f9ng l\u1ea1i corticosteroid to\u00e0n th\u00e2n n\u1ebfu b\u1ec7nh nh\u00e2n c\u00f3 d\u1ea5u hi\u1ec7u ho\u1eb7c tri\u1ec7u ch\u1ee9ng \u1ee9c ch\u1ebf th\u01b0\u1ee3ng th\u1eadn v\u00e0 n\u00ean \u00e1p d\u1ee5ng ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb th\u00edch h\u1ee3p kh\u00e1c.<\/p>\n<p>Trong th\u1eddi gian chuy\u1ec3n t\u1eeb corticosteroid to\u00e0n th\u00e2n sang mometasone furoate d\u1ea1ng x\u1ecbt, m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n c\u00f3 bi\u1ec3u hi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a ng\u1eebng s\u1eed d\u1ee5ng corticosteroid to\u00e0n th\u00e2n (nh\u01b0 \u0111au kh\u1edbp v\u00e0\/ ho\u1eb7c c\u01a1, m\u1ec7t m\u1ecfi v\u00e0 tr\u1ea7m c\u1ea3m giai \u0111o\u1ea1n \u0111\u1ea7u) m\u1eb7c d\u00f9 c\u00f3 gi\u1ea3m c\u00e1c tri\u1ec7u ch\u1ee9ng \u1edf m\u0169i v\u00e0 v\u1eabn c\u1ea7n d\u00f9ng ti\u1ebfp mometasone furoate d\u1ea1ng x\u1ecbt. Giai \u0111o\u1ea1n chuy\u1ec3n \u0111\u1ed5i n\u00e0y c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n c\u00e1c d\u1ecb \u1ee9ng \u0111\u00e3 c\u00f3, nh\u01b0 vi\u00eam k\u1ebft m\u1ea1c d\u1ecb \u1ee9ng v\u00e0 ch\u00e0m, m\u00e0 tr\u01b0\u1edbc kia b\u1ecb che l\u1ea5p b\u1edfi \u0111i\u1ec1u tr\u1ecb corticosteroid to\u00e0n th\u00e2n.<\/p>\n<p>Trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u0111\u1ed1i ch\u1ee9ng v\u1edbi gi\u1ea3 d\u01b0\u1ee3c tr\u00ean b\u1ec7nh nh\u00e2n nhi \u0111\u00e3 d\u00f9ng 100 microgram\/ng\u00e0y mometasone furoate d\u1ea1ng x\u1ecbt trong m\u1ed9t n\u0103m, kh\u00f4n 1 c\u00f3 hi\u1ec7n t\u01b0\u1ee3ng gi\u1ea3m t\u1ed1c \u0111\u1ed9 l\u1edbn c\u1ee7a tr\u1ebb.<\/p>\n<p>Nh\u1eefng b\u1ec7nh nh\u00e2n d\u00f9ng corticosteroid \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch m\u1ea1nh n\u00ean \u0111\u01b0\u1ee3c c\u1ea3nh b\u00e1o nguy c\u01a1 khi ti\u1ebfp x\u00fac v\u1edbi m\u1ed9t v\u00e0i nhi\u1ec5m khu\u1ea9n (nh\u01b0 th\u1ee7y \u0111\u1eadu, s\u1edfi) v\u00e0 t\u1ea7m quan tr\u1ecdng c\u1ee7a vi\u1ec7c kh\u00e1m y khoa n\u1ebfu ti\u1ebfp x\u00fac v\u1edbi nhi\u1ec5m khu\u1ea9n tr\u00ean.<\/p>\n<p>R\u1ea5t hi\u1ebfm b\u00e1o c\u00e1o th\u1ee7ng v\u00e1ch ng\u0103n ho\u1eb7c t\u0103ng \u00e1p l\u1ef1c n\u1ed9i nh\u00e3n sau khi s\u1eed d\u1ee5ng corticosteroid x\u1ecbt b\u00ean trong m\u0169i.<\/p>\n<p>B\u1ec7nh nh\u00e2n n\u00ean \u0111i kh\u00e1m ngay n\u1ebfu th\u1ea5y c\u00e1c d\u1ea5u hi\u1ec7u ho\u1eb7c tri\u1ec7u ch\u1ee9ng nhi\u1ec5m khu\u1ea9n n\u1eb7ng (nh\u01b0 s\u1ed1t, \u0111au nhi\u1ec1u v\u00e0 k\u00e9o d\u00e0i m\u1ed9t b\u00ean m\u1eb7t\/ r\u0103ng ho\u1eb7c s\u01b0ng m\u1eb7t, m\u1eaft ho\u1eb7c ngo\u1ea1i vi m\u1eaft, ho\u1eb7c c\u00e1c tri\u1ec7u ch\u1ee9ng x\u1ea5u \u0111i sau m\u1ed9t th\u1eddi gian c\u1ea3i thi\u1ec7n). S\u1ea3n ph\u1ea9m n\u00e0y c\u00f3 ch\u1ee9a benzalkonium clorid, khi d\u00f9ng theo \u0111\u01b0\u1eddng t\u1ea1i ch\u1ed7 c\u00f3 th\u1ec3 g\u00e2y d\u1ecb \u1ee9ng v\u00e0 c\u00e1c ph\u1ea3n \u1ee9ng tr\u00ean da.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>Thu\u1ed1c kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe ho\u1eb7c v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n<p><strong>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/strong><\/p>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: B3<\/p>\n<p>US FDA pregnancy category: C<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>Kh\u00f4ng c\u00f3 ho\u1eb7c r\u1ea5t \u00edt d\u1eef li\u1ec7u v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng mometasone furoate \u1edf ph\u1ee5 n\u1eef mang thai. C\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y \u0111\u1ed9c t\u00ednh \u0111\u1ed1i v\u1edbi kh\u1ea3 n\u0103ng sinh s\u1ea3n.<\/p>\n<p>C\u0169ng nh\u01b0 c\u00e1c ch\u1ebf ph\u1ea9m corticosteroid d\u00f9ng \u0111\u01b0\u1eddng m\u0169i kh\u00e1c, n\u00ean d\u00f9ng mometasone furoate cho ph\u1ee5 n\u1eef mang thai khi l\u1ee3i \u00edch \u0111i\u1ec1u tr\u1ecb v\u01b0\u1ee3t tr\u1ed9i nguy c\u01a1 cho m\u1eb9 v\u00e0 thai nhi. \u0110\u1ee9a tr\u1ebb \u0111\u01b0\u1ee3c sinh ra sau khi m\u1eb9 d\u00f9ng corticosteroid trong th\u1eddi gian mang thai n\u00ean \u0111\u01b0\u1ee3c theo d\u00f5i c\u1ea9n th\u1eadn suy tuy\u1ebfn th\u01b0\u1ee3ng th\u1eadn.<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>Kh\u00f4ng bi\u1ebft li\u1ec7u mometasone furoate c\u00f3 \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9 hay kh\u00f4ng. C\u0169ng nh\u01b0 c\u00e1c ch\u1ebf ph\u1ea9m corticosteroid d\u00f9ng \u0111\u01b0\u1eddng m\u0169i kh\u00e1c, vi\u1ec7c quy\u1ebft \u0111\u1ecbnh ng\u1eebng cho con b\u00fa hay ng\u1eebng \u0111i\u1ec1u tr\u1ecb mometasone furoate ph\u1ea3i t\u00ednh \u0111\u1ebfn l\u1ee3i \u00edch c\u1ee7a vi\u1ec7c cho con b\u00fa v\u00e0 l\u1ee3i \u00edch \u0111i\u1ec1u tr\u1ecb cho ng\u01b0\u1eddi m\u1eb9.<\/p>\n<p><em>Kh\u1ea3 n\u0103ng sinh s\u1ea3n:<\/em><\/p>\n<p>Kh\u00f4ng c\u00f3 d\u1eef li\u1ec7u l\u00e2m s\u00e0ng li\u00ean quan \u0111\u1ebfn t\u00e1c d\u1ee5ng c\u1ee7a mometasone furoate tr\u00ean kh\u1ea3 n\u0103ng sinh, s\u1ea3n. C\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y c\u00f3 \u0111\u1ed9c t\u00ednh tr\u00ean sinh s\u1ea3n nh\u01b0ng kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng sinh s\u1ea3n.<\/p>\n<p><strong>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/strong><\/p>\n<p>Vi\u00eam m\u0169i d\u1ecb \u1ee9ng theo m\u00f9a ho\u1eb7c quanh n\u0103m: C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 t\u1ea1i ch\u1ed7 li\u00ean quan \u0111\u1ebfn \u0111i\u1ec1u tr\u1ecb \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o trong c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng \u1edf b\u1ec7nh nh\u00e2n ng\u01b0\u1eddi l\u1edbn v\u00e0 thanh thi\u1ebfu ni\u00ean bao g\u1ed3m \u0111au \u0111\u1ea7u (8%), ch\u1ea3y m\u00e1u cam (nh\u01b0 ch\u1ea3y m\u00e1u th\u1ef1c s\u1ef1, ch\u1ea3y m\u00e1u ni\u00eam m\u1ea1c v\u00e0 \u0111\u1ed1m ch\u1ea3y m\u00e1u) (8%), vi\u00eam h\u1ea7u h\u1ecdng (4%), n\u00f3ng r\u00e1t m\u0169i (2%), k\u00edch th\u00edch m\u0169i (2%), v\u00e0 lo\u00e9t m\u0169i (1%), nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 n\u00e0y ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y v\u1edbi corticosteroid x\u1ecbt m\u0169i. Ch\u1ea3y m\u00e1u cam th\u01b0\u1eddng t\u1ef1 kh\u1ecfi v\u00e0 t\u1eeb nh\u1eb9 \u0111\u1ebfn n\u1eb7ng, xu\u1ea5t hi\u1ec7n v\u1edbi t\u1ec9 l\u1ec7 cao h\u01a1n so v\u1edbi placebo (5%) nh\u01b0ng v\u1edbi t\u1ef7 l\u1ec7 b\u1eb1ng ho\u1eb7c th\u1ea5p h\u01a1n so v\u1edbi c\u00e1c corticosteroid d\u00f9ng \u0111\u01b0\u1eddng m\u0169i trong nghi\u00ean c\u1ee9u c\u00f3 \u0111\u1ed1i ch\u1ee9ng (l\u00ean \u0111\u1ebfn 15%). T\u1ef7 l\u1ec7 c\u1ee7a c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00e1c l\u00e0 t\u01b0\u01a1ng t\u1ef1 nh\u01b0 placebo.<\/p>\n<p>\u1ede b\u1ec7nh nhi, t\u1ef7 l\u1ec7 c\u1ee7a c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 \u0111au \u0111\u1ea7u (3%), ch\u1ea3y m\u00e1u cam (6%), k\u00edch th\u00edch m\u0169i (2%) v\u00e0 h\u1eaft h\u01a1i (2%) l\u00e0 t\u01b0\u01a1ng t\u1ef1 nh\u01b0 placebo.<\/p>\n<p>C\u00e1c ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn t\u1ee9c th\u00ec (nh\u01b0 co th\u1eaft ph\u1ebf qu\u1ea3n, kh\u00f3 th\u1edf), nh\u01b0ng hi\u1ebfm, c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n sau khi s\u1eed d\u1ee5ng mometasone furoate \u0111\u01b0\u1eddng m\u0169i. R\u1ea5t hi\u1ebfm c\u00f3 b\u00e1o c\u00e1o v\u1ec1 ph\u1ea3n \u1ee9ng ph\u1ea3n v\u1ec7 v\u00e0 ph\u00f9 m\u1ea1ch.<\/p>\n<p>R\u1ea5t hi\u1ebfm c\u00f3 b\u00e1o c\u00e1o thay \u0111\u1ed5i v\u1ecb gi\u00e1c v\u00e0 kh\u1ee9u gi\u00e1c.<\/p>\n<p>Polyp m\u0169i: \u1ede nh\u1eefng b\u1ec7nh nh\u00e2n polyp m\u0169i, nh\u00ecn chung t\u1ef7 l\u1ec7 xu\u1ea5t hi\u1ec7n c\u00e1c bi\u1ec3u hi\u1ec7n b\u1ea5t l\u1ee3i l\u00e0 t\u01b0\u01a1ng t\u1ef1 nh\u01b0 placebo v\u00e0 t\u01b0\u01a1ng t\u1ef1 nh\u01b0 t\u00e1c d\u1ee5ng ph\u1ee5 quan s\u00e1t th\u1ea5y v\u1edbi vi\u00eam m\u0169i d\u1ecb \u1ee9ng.<\/p>\n<p>Vi\u00eam m\u0169i xoang c\u1ea5p: \u1ede nh\u1eefng b\u1ec7nh nh\u00e2n vi\u00eam m\u0169i xoang c\u1ea5p, nh\u00ecn chung t\u1ef7 l\u1ec7 xu\u1ea5t hi\u1ec7n c\u00e1c bi\u1ec3u hi\u1ec7n b\u1ea5t l\u1ee3i l\u00e0 t\u01b0\u01a1ng t\u1ef1 nh\u01b0 placebo v\u00e0 t\u01b0\u01a1ng t\u1ef1 nh\u01b0 t\u00e1c d\u1ee5ng ph\u1ee5 quan s\u00e1t th\u1ea5y v\u1edbi vi\u00eam m\u0169i d\u1ecb \u1ee9ng.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 trong c\u00e1c \u0111\u1ee3t vi\u00eam xoang c\u1ea5p: \u1ede ng\u01b0\u1eddi l\u1edbn v\u00e0 thanh thi\u1ebfu ni\u00ean d\u00f9ng mometasone furoate 0,05% d\u1ea1ng x\u1ecbt m\u0169i nh\u01b0 \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 trong \u0111\u1ee3t vi\u00eam xoang c\u1ea5p, c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 li\u00ean quan \u0111\u1ebfn \u0111i\u1ec1u tr\u1ecb, xu\u1ea5t hi\u1ec7n v\u1edbi t\u1ef7 l\u1ec7 t\u01b0\u01a1ng t\u1ef1 nh\u01b0 placebo, bao g\u1ed3m \u0111au \u0111\u1ea7u (2%), vi\u00eam h\u1ea7u h\u1ecdng (1%), n\u00f3ng r\u00e1t m\u0169i (1%) v\u00e0 k\u00edch th\u00edch m\u0169i (1%). Ch\u1ea3y m\u00e1u cam t\u1eeb nh\u1eb9 \u0111\u1ebfn n\u1eb7ng v\u00e0 c\u0169ng xu\u1ea5t hi\u1ec7n v\u1edbi t\u1ef7 l\u1ec7 so s\u00e1nh \u0111\u01b0\u1ee3c v\u1edbi placebo (5% so v\u1edbi 4%). Th\u00f4ng b\u00e1o cho b\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 khi d\u00f9ng thu\u1ed1c<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<p><strong>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/strong><\/p>\n<p>Ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c. V\u1edbi c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i nh\u1eb9, th\u01b0\u1eddng ch\u1ec9 c\u1ea7n ng\u1eebng thu\u1ed1c. Tr\u01b0\u1eddng h\u1ee3p m\u1eabn c\u1ea3m n\u1eb7ng ho\u1eb7c ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, c\u1ea7n ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 (gi\u1eef tho\u00e1ng kh\u00ed v\u00e0 d\u00f9ng epinephrin, th\u1edf oxygen, d\u00f9ng kh\u00e1ng histamin, corticoid&#8230;).<\/p>\n<p><strong>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/strong><\/p>\n<p>Mometasone furoate l\u00e0 m\u1ed9t ch\u1ea5t n\u1ec1n c\u1ee7a CYP3A4. Mometasone furoate s\u1eed d\u1ee5ng k\u1ebft h\u1ee3p v\u1edbi loratadin kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng c\u1ee7a loratadin v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh c\u1ee7a n\u00f3. Kh\u00f4ng d\u1ef1 \u0111o\u00e1n \u0111\u01b0\u1ee3c n\u1ed3ng \u0111\u1ed9 mometasone furoate huy\u1ebft t\u01b0\u01a1ng. \u0110i\u1ec1u tr\u1ecb k\u1ebft h\u1ee3p \u0111\u01b0\u1ee3c dung n\u1ea1p t\u1ed1t.<\/p>\n<p><strong>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/strong><\/p>\n<p>Do sinh kh\u1ea3 d\u1ee5ng to\u00e0n th\u00e2n c\u1ee7a mometasone furoate d\u1ea1ng x\u1ecbt kh\u00f4ng \u0111\u00e1ng k\u1ec3 (&lt; 0,1%), qu\u00e1 li\u1ec1u kh\u00f4ng y\u00eau c\u1ea7u \u0111i\u1ec1u tr\u1ecb m\u00e0 ch\u1ec9 c\u1ea7n theo d\u00f5i, s\u1eed d\u1ee5ng ti\u1ebfp li\u1ec1u k\u1ebf toa th\u00edch h\u1ee3p.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/strong><\/p>\n<p><strong>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/strong><\/p>\n<p>Nh\u00f3m t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd: Corticoid \u2013 ch\u1ed1ng vi\u00eam m\u0169i theo \u0111\u01b0\u1eddng t\u1ea1i ch\u1ed7.<\/p>\n<p>M\u00e3 ATC: R01A D09.<\/p>\n<p>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: Mometasone furoate l\u00e0 m\u1ed9t glucocorticosteroid d\u00f9ng ngo\u00e0i v\u1edbi t\u00ednh ch\u1ea5t ch\u1ed1ng vi\u00eam t\u1ea1i ch\u1ed7 \u1edf c\u00e1c li\u1ec1u kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng to\u00e0n th\u00e2n.<\/p>\n<p>C\u00f3 l\u1ebd, c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng ch\u1ed1ng d\u1ecb \u1ee9ng v\u00e0 kh\u00e1ng vi\u00eam c\u1ee7a mometasone furoate d\u1ef1a v\u00e0o s\u1ef1 \u1ee9c ch\u1ebf c\u00e1c ch\u1ea5t trung gian g\u00e2y ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng.<\/p>\n<p>Mometasone \u1ee9c ch\u1ebf \u0111\u00e1ng k\u1ec3 s\u1ef1 ph\u00f3ng th\u00edch c\u00e1c leucotrien t\u1eeb t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u \u1edf b\u1ec7nh nh\u00e2n d\u1ecb \u1ee9ng. Ngo\u00e0i ra, n\u00f3 l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf r\u1ea5t m\u1ea1nh vi\u1ec7c s\u1ea3n xu\u1ea5t Th2 cytokens, IL-4 v\u00e0 IL-5, t\u1eeb t\u1ebf b\u00e0o CD4+T \u1edf ng\u01b0\u1eddi.<\/p>\n<p>Trong th\u1eed nghi\u1ec7m t\u1ebf b\u00e0o, mometasone furoate \u00edt nh\u1ea5t m\u1ea1nh g\u1ea5p 10 l\u1ea7n h\u01a1n steroid kh\u00e1c (beclometasone dipropionate \u2013BDP- bethametasone, hydrocortisone v\u00e0 dexametasone) trong \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p v\u00e0 ph\u00f3ng th\u00edch IL-1, IL-6 v\u00e0 TNFa. Trong s\u1ef1 \u1ee9c ch\u1ebf s\u1ef1 s\u1ea3n xu\u1ea5t IL-5, mometasone furoate (IC50 = 0,12 Nm) \u00edt nh\u1ea5t m\u1ea1nh g\u1ea5p 6 l\u1ea7n h\u01a1n BDP v\u00e0 Methametasone. H\u01a1n n\u1eefa, mometasone furoate \u0111\u01b0\u1ee3c xem l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf m\u1ea1nh vi\u1ec7c t\u1ed5ng h\u1ee3p leucotrien h\u01a1n BDP trong b\u1ea1ch c\u1ea7u h\u1ed7n h\u1ee3p \u1edf b\u1ec7nh nh\u00e2n c\u00f3 c\u01a1 \u0111\u1ecba m\u1eabn c\u1ea3m.<\/p>\n<p>Trong c\u00e1c nghi\u00ean c\u1ee9u d\u00f9ng c\u00e1c kh\u00e1ng nguy\u00ean \u0111\u01b0\u1eddng m\u0169i, mometasone furoate cho th\u1ea5y t\u00e1c d\u1ee5ng kh\u00e1ng vi\u00eam \u1edf c\u1ea3 \u0111\u00e1p \u1ee9ng d\u1ecb \u1ee9ng s\u1edbm v\u00e0 mu\u1ed9n. \u0110i\u1ec1u n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh b\u1edfi s\u1ef1 gi\u1ea3m histamin v\u00e0 c\u00e1c b\u1ea1ch c\u1ea7u \u01b0a eosin (so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c), b\u1ea1ch c\u1ea7u trung t\u00ednh v\u00e0 gi\u1ea3m protein k\u1ebft d\u00ednh t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 (so v\u1edbi kh\u1edfi ph\u00e1t).<\/p>\n<p>Hi\u1ec7u qu\u1ea3 l\u00e2m s\u00e0ng r\u00f5 r\u1ec7t b\u1eaft \u0111\u1ea7u s\u1edbm nh\u1ea5t l\u00e0 12 gi\u1edd sau li\u1ec1u \u0111\u1ea7u ti\u00ean.<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>Mometasone furoate l\u00e0 m\u1ed9t glucocorticosteroid d\u00f9ng ngo\u00e0i v\u1edbi t\u00ednh ch\u1ea5t ch\u1ed1ng vi\u00eam t\u1ea1i ch\u1ed7 \u1edf c\u00e1c li\u1ec1u kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng to\u00e0n th\u00e2n.<\/p>\n<p>C\u00f3 l\u1ebd, c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng kh\u00e1ng d\u1ecb \u1ee9ng v\u00e0 kh\u00e1ng vi\u00eam c\u1ee7a Mometasone furoate d\u1ef1a v\u00e0o s\u1ef1 \u1ee9c ch\u1ebf c\u00e1c ch\u1ea5t trung gian g\u00e2y ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng.<\/p>\n<p>Mometasone \u1ee9c ch\u1ebf \u0111\u00e1ng k\u1ec3 s\u1ef1 ph\u00f3ng th\u00edch leucotrienes t\u1eeb t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u \u1edf b\u1ec7nh nh\u00e2n d\u1ecb \u1ee9ng. Ngo\u00e0i ra, n\u00f3 l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf r\u1ea5t m\u1ea1nh vi\u1ec7c s\u1ea3n xu\u1ea5t Th2 cytokines, IL-4 v\u00e0 IL-5, t\u1eeb t\u1ebf b\u00e0o CD4+T \u1edf ng\u01b0\u1eddi.<\/p>\n<p>Trong th\u1eed nghi\u1ec7m t\u1ebf b\u00e0o, Mometasone furoate \u00edt nh\u1ea5t m\u1ea1nh g\u1ea5p 10 l\u1ea7n h\u01a1n steroid kh\u00e1c (beclometasone dipropionate-BDP-betametasone, hydrocortisone v\u00e0 dexametasone) trong \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p v\u00e0 ph\u00f3ng th\u00edch IL-1, IL-6 v\u00e0 TNF\u03b1. Trong s\u1ef1 \u1ee9c ch\u1ebf s\u1ef1 s\u1ea3n xu\u1ea5t IL-5, mometasone furoate (ICM = 0,12Nm) \u00edt nh\u1ea5t m\u1ea1nh g\u1ea5p 6 l\u1ea7n h\u01a1n BDP v\u00e0 betametasone. H\u01a1n n\u1eefa, mometasone furoate \u0111\u01b0\u1ee3c xem l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf m\u1ea1nh vi\u1ec7c t\u1ed5ng h\u1ee3p leucotriene h\u01a1n BDP trong b\u1ea1ch c\u1ea7u h\u1ed7n h\u1ee3p \u1edf b\u1ec7nh nh\u00e2n c\u00f3 c\u01a1 \u0111\u1ecba m\u1eabn c\u1ea3m.<\/p>\n<p>Trong c\u00e1c nghi\u00ean c\u1ee9u d\u00f9ng c\u00e1c kh\u00e1ng nguy\u00ean \u0111\u01b0\u1eddng m\u0169i, mometasone furoate cho th\u1ea5y t\u00e1c d\u1ee5ng kh\u00e1ng vi\u00eam \u1edf c\u1ea3 \u0111\u00e1p \u1ee9ng d\u1ecb \u1ee9ng s\u1edbm v\u00e0 mu\u1ed9n. \u0110i\u1ec1u n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh b\u1edfi s\u1ef1 gi\u1ea3m histamine v\u00e0 c\u00e1c b\u1ea1ch c\u1ea7u \u01b0a eosin (so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c), b\u1ea1ch c\u1ea7u trung t\u00ednh v\u00e0 gi\u1ea3m protein k\u1ebft d\u00ednh t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 (so v\u1edbi kh\u1edfi ph\u00e1t).<\/p>\n<p>Hi\u1ec7u qu\u1ea3 l\u00e2m s\u00e0ng r\u00f5 r\u1ec7t b\u1eaft \u0111\u1ea7u s\u1edbm nh\u1ea5t l\u00e0 12 gi\u1edd sau li\u1ec1u \u0111\u1ea7u ti\u00ean.<\/p>\n<p><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/p>\n<p><strong>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/strong><\/p>\n<p><em>H\u1ea5p thu<\/em>: mometasone furoate d\u00f9ng d\u1ea1ng x\u1ecbt m\u0169i c\u00f3 sinh kh\u1ea3 d\u1ee5ng to\u00e0n th\u00e2n kh\u00f4ng \u0111\u00e1ng k\u1ec3 (&lt; 0,1%). H\u1ed7n d\u1ecbch mometasone furoate h\u1ea5p th\u1ee5 k\u00e9m \u1edf \u0111\u01b0\u1eddng ti\u00eau h\u00f3a; m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c nu\u1ed1t v\u00e0 v\u00e0 h\u1ea5p th\u1ee5 tr\u1ea3i qua m\u1ed9t qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a b\u01b0\u1edbc \u0111\u1ea7u r\u1ed9ng r\u00e3i tr\u01b0\u1edbc khi th\u1ea3i tr\u1eeb qua n\u01b0\u1edbc ti\u1ec3u v\u00e0 m\u1eadt.<\/p>\n<p><em>Ph\u00e2n b\u1ed1<\/em>: trong nghi\u00ean c\u1ee9u in-vitro, t\u1ef7 l\u1ec7 protein li\u00ean k\u1ebft v\u1edbi mometasone furoate \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o 98-99% v\u1edbi n\u1ed3ng \u0111\u1ed9 gi\u1edbi h\u1ea1n 5-500ng\/ml.<\/p>\n<p><em>Chuy\u1ec3n h\u00f3a<\/em>: C\u00e1c nghi\u00ean c\u1ee9u ch\u1ec9 ra r\u1eb1ng l\u01b0\u1ee3ng mometasone furoate b\u1ecb nu\u1ed1t v\u00e0 h\u1ea5p th\u1ee5 \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a r\u1ed9ng r\u00e3i v\u00e0 chuy\u1ec3n h\u00f3a th\u00e0nh nhi\u1ec1u ch\u1ea5t. Kh\u00f4ng c\u00f3 ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n trong huy\u1ebft t\u01b0\u01a1ng. M\u1ed9t trong s\u1ed1 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a \u0111\u01b0\u1ee3c h\u00ecnh th\u00e0nh trong th\u1eed nghi\u1ec7m in-vitro l\u00e0 63-hydroxy-mometasone furoate. Ch\u1ea5t chuy\u1ec3n h\u00f3a h\u00ecnh th\u00e0nh trong microsomes \u1edf gan ng\u01b0\u1eddi \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t b\u1edfi cytochrom P-450 3A4 (CYP3A4).<\/p>\n<p><em>Th\u1ea3i tr\u1eeb<\/em>: Thu\u1ed1c b\u1ecb th\u1ea3i tr\u1eeb h\u1ea7u h\u1ebft d\u01b0\u1edbi d\u1ea1ng c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a qua m\u1eadt v\u00e0 m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf qua n\u01b0\u1edbc ti\u1ec3u.<\/p>\n<p><strong>5.3 Gi\u1ea3i th\u00edch: <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong>5.4 Thay th\u1ebf thu\u1ed1c : <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/strong><\/p>\n<p><strong>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/strong><\/p>\n<p>T\u00e1 d\u01b0\u1ee3c: glycerol, cellulose vi tinh th\u1ec3 v\u00e0 carmellose natri (65cps), acid citric monohydrat, natri citrat, polysorbat 80, benzalkonium chlorid, n\u01b0\u1edbc tinh khi\u1ebft.<\/p>\n<p><strong>6.2. T\u01b0\u01a1ng k\u1ef5 :<\/strong><\/p>\n<p>Kh\u00f4ng \u00e1p d\u1ee5ng.<\/p>\n<p><strong>6.3. B\u1ea3o qu\u1ea3n: <\/strong><\/p>\n<p>B\u1ea3o qu\u1ea3n: Trong bao b\u00ec k\u00edn \u1edf nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30\u00b0C. Kh\u00f4ng l\u00e0m \u0111\u00f4ng l\u1ea1nh. L\u1eafc k\u1ef9 tr\u01b0\u1edbc khi d\u00f9ng.<\/p>\n<p><strong>6.4. Th\u00f4ng tin kh\u00e1c :<\/strong><\/p>\n<p>Kh\u00f4ng c\u00f3.<\/p>\n<p><strong>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/strong><\/p>\n<p>D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n<p>Ho\u1eb7c HDSD Thu\u1ed1c.<\/p>\n<p><strong>7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<\/strong><\/p>\n<p>B\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c s\u01b0u t\u1ea7m ho\u1eb7c vi\u1ebft b\u1edfi: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-tac-gia-bac-sy-do-my-linh\/\">B\u00e1c s\u0129 nhi khoa &#8211; \u0110\u1ed7 M\u1ef9 Linh.<\/a><\/p>\n<p>Ki\u1ec3m duy\u1ec7t , hi\u1ec7u \u0111\u00ednh v\u00e0 \u0111\u0103ng t\u1ea3i: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-ve-pharmog-team\/\">PHARMOG TEAM<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Eu-Fastmome l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Eu-Fastmome (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;) 1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Mometasone Ph\u00e2n lo\u1ea1i: Thu\u1ed1c Corticosteroids. Nh\u00f3m ph\u00e1p l\u00fd: [&hellip;]<\/p>\n","protected":false},"author":8612,"featured_media":30273,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[1196],"class_list":["post-30272","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-mometasone"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/30272","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/8612"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=30272"}],"version-history":[{"count":2,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/30272\/revisions"}],"predecessor-version":[{"id":46058,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/30272\/revisions\/46058"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/30273"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=30272"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=30272"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=30272"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}