{"id":28376,"date":"2021-01-31T09:13:44","date_gmt":"2021-01-31T02:13:44","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=28376"},"modified":"2025-01-08T11:52:34","modified_gmt":"2025-01-08T04:52:34","slug":"ondansetron-ondansetron-kabi","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/ondansetron-ondansetron-kabi\/","title":{"rendered":"Ondansetron &#8211; Ondansetron Kabi"},"content":{"rendered":"<p><em>Thu\u1ed1c Ondansetron Kabi l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Ondansetron Kabi (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;)<\/em><\/p>\n<p><strong>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: <\/strong><\/p>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <\/strong><a href=\"https:\/\/pharmog.com\/wp\/ondansetron\/\"><strong>Ondansetron<\/strong><\/a><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u1ed1c ch\u1ed1ng n\u00f4n, \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 5-HT3.<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): A04AA01.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em><\/strong><\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c:<\/em><\/strong> Ondansetron Kabi<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: Labesfal- Laborat\u00f3rios Almiro, S.A.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng: <\/strong><\/p>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>Dung d\u1ecbch ti\u00eam 2mg\/ml. H\u1ed9p 5 \u1ed1ng x4ml<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>ONDANSETRON KABI 2mg\/ml<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean n\u00e9n bao phim c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Ondansetron<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>8 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"455\" height=\"444\" class=\"wp-image-28377\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/01\/word-image-433.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/01\/word-image-433.png 455w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/01\/word-image-433-300x293.png 300w\" sizes=\"auto, (max-width: 455px) 100vw, 455px\" \/><\/p>\n<p><strong>3. Video by Pharmog:<\/strong><\/p>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe loading=\"lazy\" title=\"[Pharmog SS1 - T\u1eadp 02] - D\u01b0\u1ee3c l\u00fd c\u00e1c thu\u1ed1c ch\u1ed1ng n\u00f4n\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/I1kZxJHepDY?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<p><strong>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng: <\/strong><\/p>\n<p><strong>4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>Ng\u01b0\u1eddi l\u1edbn:<\/p>\n<p>Ondansetron \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 d\u1ef1 ph\u00f2ng v\u00e0 \u0111i\u1ec1u tr\u1ecb bu\u1ed3n n\u00f4n, n\u00f4n do h\u00f3a tr\u1ecb, x\u1ea1 tr\u1ecb g\u00e2y ra. Ondansetron c\u0169ng \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 d\u1ef1 ph\u00f2ng v\u00e0 \u0111i\u1ec1u tr\u1ecb bu\u1ed3n n\u00f4n, n\u00f4n h\u1eadu ph\u1eabu (PONV)<\/p>\n<p>Tr\u1ebb em:<\/p>\n<p>Ondansetron \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 ki\u1ec3m so\u00e1t bu\u1ed3n n\u00f4n, n\u00f4n do h\u00f3a tr\u1ecb g\u00e2y ra \u1edf tr\u1ebb em &gt; 6 th\u00e1ng tu\u1ed5i v\u00e0 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 d\u1ef1 ph\u00f2ng v\u00e0 \u0111i\u1ec1u tr\u1ecb bu\u1ed3n n\u00f4n, n\u00f4n h\u1eadu ph\u1eabu \u1edf tr\u1ebb &gt; 1 th\u00e1ng tu\u1ed5i.<\/p>\n<p><strong>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/strong><\/p>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p>\u0110\u01b0\u1eddng d\u00f9ng: ti\u00eam t\u0129nh m\u1ea1ch ho\u1eb7c ti\u00eam truy\u1ec1n t\u0129nh m\u1ea1ch sau khi pha lo\u00e3ng thu\u1ed1c.<\/p>\n<p>C\u00e1ch pha thu\u1ed1c: Ondansetron 2mg\/ml c\u00f3 th\u1ec3 pha lo\u00e3ng v\u1edbi c\u00e1c dung d\u1ecbch sau \u0111\u1ec3 ti\u00eam truy\u1ec1n:<\/p>\n<p>Dung d\u1ecbch Natri clorid 9 mg\/ml (0,9 %)<\/p>\n<p>Dung d\u1ecbch Glucose 50 mg\/ml (5 % )<\/p>\n<p>Dung d\u1ecbch Mannitol 100 mg\/ml (10 % )<\/p>\n<p>Dung d\u1ecbch Ringer\u2019s lactat<\/p>\n<p>Dung d\u1ecbch pha lo\u00e3ng n\u00ean \u0111\u01b0\u1ee3c b\u1ea3o qu\u1ea3n tr\u00e1nh \u00e1nh s\u00e1ng.<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p><em>Bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n do h\u00f3a tr\u1ecb hay x\u1ea1 tr\u1ecb (CINV v\u00e0 RINV) \u1edf ng\u01b0\u1eddi l\u1edbn<\/em><\/p>\n<p>M\u1ee9c \u0111\u1ed9 g\u00e2y n\u00f4n c\u1ee7a tr\u1ecb li\u1ec7u ung th\u01b0 l\u1ec7 thu\u1ed9c v\u00e0o li\u1ec1u l\u01b0\u1ee3ng v\u00e0 s\u1ef1 ph\u1ed1i h\u1ee3p c\u00e1c thu\u1ed1c trong ph\u00e1c \u0111\u1ed3 h\u00f3a tr\u1ecb, x\u1ea1 tr\u1ecb. Vi\u1ec7c ch\u1ecdn li\u1ec1u l\u01b0\u1ee3ng s\u1eed d\u1ee5ng ph\u1ea3i c\u0103n c\u1ee9 tr\u00ean m\u1ee9c \u0111\u1ed9 g\u00e2y n\u00f4n.<\/p>\n<p><em>C\u00e1c ph\u00e1c \u0111\u1ed3 h\u00f3a tr\u1ecb v\u00e0 x\u1ea1 tr\u1ecb g\u00e2y n\u00f4n<\/em><\/p>\n<p>\u0110\u1ed1i v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n \u0111ang \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh c\u00e1c ph\u00e1c \u0111\u1ed3 h\u00f3a tr\u1ecb v\u00e0 x\u1ea1 tr\u1ecb g\u00e2y n\u00f4n, c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng ondansetron qua \u0111\u01b0\u1eddng ti\u00eam t\u0129nh m\u1ea1ch ho\u1eb7c \u0111\u01b0\u1eddng u\u1ed1ng.<\/p>\n<p>Li\u1ec1u khuy\u1ebfn c\u00e1o c\u1ee7a ondansetron khi s\u1eed d\u1ee5ng \u0111\u01b0\u1eddng ti\u00eam t\u0129nh m\u1ea1ch l\u00e0 8 mg ti\u00eam t\u0129nh m\u1ea1ch ch\u1eadm (kh\u00f4ng d\u01b0\u1edbi 30 gi\u00e2y) ngay tr\u01b0\u1edbc khi h\u00f3a tr\u1ecb, x\u1ea1 tr\u1ecb.<\/p>\n<p><em>H\u00f3a tr\u1ecb g\u00e2y n\u00f4n m\u1ea1nh, v\u00ed d\u1ee5 nh\u01b0 cisplatin li\u1ec1u cao<\/em><\/p>\n<p>Ondansetron c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ti\u00eam t\u0129nh m\u1ea1ch li\u1ec1u duy nh\u1ea5t 8 mg ngay tr\u01b0\u1edbc khi h\u00f3a tr\u1ecb. S\u1eed d\u1ee5ng li\u1ec1u tr\u00ean 8 mg \u0111\u1ebfn 16 mg ch\u1ec9 \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam truy\u1ec1n t\u0129nh m\u1ea1ch sau khi pha lo\u00e3ng trong 50-100 ml dung d\u1ecbch NaCl ho\u1eb7c c\u00e1c dung d\u1ecbch ti\u00eam truy\u1ec1n t\u01b0\u01a1ng h\u1ee3p kh\u00e1c v\u00e0 truy\u1ec1n trong kh\u00f4ng d\u01b0\u1edbi 15 ph\u00fat. Kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng li\u1ec1u duy nh\u1ea5t tr\u00ean 16 mg do c\u00f3 th\u1ec3 g\u00e2y nguy c\u01a1 k\u00e9o d\u00e0i kho\u1ea3ng QT.<\/p>\n<p>\u0110\u1ec3 ki\u1ec3m so\u00e1t n\u00f4n do ph\u00e1c \u0111\u1ed3 h\u00f3a tr\u1ecb g\u00e2y n\u00f4n m\u1ea1nh, c\u00f3 th\u1ec3 ti\u00eam t\u0129nh m\u1ea1ch ch\u1eadm (kh\u00f4ng d\u01b0\u1edbi 30 gi\u00e2y) ondansetron li\u1ec1u 8 mg, sau \u0111\u00f3 ti\u1ebfp t\u1ee5c ti\u00eam t\u0129nh m\u1ea1ch 2 li\u1ec1u ondansetron 8 mg c\u00e1ch nhau 2-4 gi\u1edd ho\u1eb7c c\u00f3 th\u1ec3 ti\u00eam truy\u1ec1n t\u0129nh m\u1ea1ch li\u1ec1u 1 mg\/gi\u1edd trong t\u1ed1i \u0111a 24 gi\u1edd.<\/p>\n<p>Hi\u1ec7u qu\u1ea3 c\u1ee7a ondansetron \u0111\u1ed1i v\u1edbi c\u00e1c ph\u00e1c \u0111\u1ed3 h\u00f3a tr\u1ecb g\u00e2y n\u00f4n m\u1ea1nh c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c t\u0103ng th\u00eam b\u1eb1ng c\u00e1ch ti\u00eam t\u0129nh m\u1ea1ch 1 li\u1ec1u b\u1ed5 sung dexamethason natri phosphat 20 mg tr\u01b0\u1edbc khi h\u00f3a tr\u1ecb.<\/p>\n<p>\u0110i\u1ec1u ch\u1ec9nh li\u1ec1u \u1edf c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng \u0111\u1eb7c bi\u1ec7t<\/p>\n<p><em>B\u1ec7nh nh\u00e2n cao tu\u1ed5i:<\/em><\/p>\n<p>Ondansetron \u0111\u01b0\u1ee3c dung n\u1ea1p t\u1ed1t \u1edf c\u00e1c b\u1ec7nh nh\u00e2n tr\u00ean 65 tu\u1ed5i v\u00e0 kh\u00f4ng c\u1ea7n ph\u1ea3i \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u l\u01b0\u1ee3ng, t\u1ea7n su\u1ea5t s\u1eed d\u1ee5ng v\u00e0 \u0111\u01b0\u1eddng s\u1eed d\u1ee5ng.<\/p>\n<p><em>B\u1ec7nh nh\u00e2n suy th\u1eadn:<\/em><\/p>\n<p>Kh\u00f4ng c\u1ea7n ph\u1ea3i \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u h\u00e0ng ng\u00e0y, t\u1ea7n s\u1ed1 s\u1eed d\u1ee5ng c\u0169ng nh\u01b0 \u0111\u01b0\u1eddng s\u1eed d\u1ee5ng.<\/p>\n<p><em>B\u1ec7nh nh\u00e2n suy gan:<\/em><\/p>\n<p>S\u1ef1 thanh th\u00e0i c\u1ee7a ondansetron gi\u1ea3m v\u00e0 th\u1eddi gian b\u00e1n th\u1ea3i k\u00e9o d\u00e0i \u1edf c\u00e1c b\u1ec7nh nh\u00e2n suy gan m\u1ee9c \u0111\u1ed9 trung b\u00ecnh \u0111\u1ebfn n\u1eb7ng. \u1ede c\u00e1c b\u1ec7nh nh\u00e2n n\u00e0y, kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng t\u1ed5ng li\u1ec1u h\u00e0ng ng\u00e0y v\u01b0\u1ee3t qu\u00e1 8 mg.<\/p>\n<p><em>B\u1ec7nh nh\u00e2n k\u00e9m chuy\u1ec3n h\u00f3a spartein\/debrisoquin:<\/em><\/p>\n<p>Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a ondansetron kh\u00f4ng b\u1ecb thay \u0111\u1ed5i \u1edf c\u00e1c b\u1ec7nh nh\u00e2n k\u00e9m chuy\u1ec3n h\u00f3a spartein v\u00e0 debrisoquin. Do \u0111\u00f3, \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y, khi s\u1eed d\u1ee5ng ondansetron v\u1edbi c\u00e1c li\u1ec1u l\u1eb7p l\u1ea1i, s\u1ebd kh\u00f4ng l\u00e0m thay \u0111\u1ed5i t\u1ed5ng l\u01b0\u1ee3ng thu\u1ed1c trong tu\u1ea7n ho\u00e0n so v\u1edbi ng\u01b0\u1eddi b\u00ecnh th\u01b0\u00f2ng. Kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u l\u01b0\u1ee3ng hay s\u1ed1 l\u1ea7n s\u1eed d\u1ee5ng h\u00e0ng ng\u00e0y.<\/p>\n<p><em>Bu\u1ed3n n\u00f4n, n\u00f4n do h\u00f3a tr\u1ecb \u1edf tr\u1ebb em &gt; 6 th\u00e1ng v\u00e0 thi\u1ebfu ni\u00ean:<\/em><\/p>\n<p>Li\u1ec1u l\u01b0\u1ee3ng s\u1eed d\u1ee5ng c\u00f3 th\u1ec3 c\u0103n c\u1ee9 tr\u00ean di\u1ec7n t\u00edch da c\u01a1 th\u1ec3 (BSA) ho\u1eb7c th\u1ec3 tr\u1ecdng &#8211; xem ph\u00eda d\u01b0\u1edbi.<\/p>\n<p><em>Li\u1ec1u t\u00ednh theo di\u1ec7n t\u00edch da c\u01a1 th\u1ec3 (BSA):<\/em><\/p>\n<p>Ondansetron \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ngay tr\u01b0\u1edbc khi h\u00f3a tr\u1ecb b\u1eb1ng ti\u00eam t\u0129nh m\u1ea1ch li\u1ec1u duy nh\u1ea5t 5 mg\/m2. Li\u1ec1u ti\u00eam t\u0129nh m\u1ea1ch kh\u00f4ng \u0111\u01b0\u1ee3c v\u01b0\u1ee3t qu\u00e1 8 mg.<\/p>\n<p>Li\u1ec1u u\u1ed1ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh sau \u0111\u00f3 12 gi\u1edd v\u00e0 c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng li\u00ean t\u1ee5c trong 5 ng\u00e0y (xem b\u1ea3ng 1). T\u1ed5ng li\u1ec1u h\u00e0ng ng\u00e0y kh\u00f4ng \u0111\u01b0\u1ee3c v\u01b0\u1ee3t qu\u00e1 li\u1ec1u c\u1ee7a ng\u01b0\u1eddi l\u1edbn 32 mg.<\/p>\n<p>B\u1ea3ng 1: Li\u1ec1u t\u00ednh theo di\u1ec7n t\u00edch da (BSA) \u0111\u1ed1i v\u1edbi bu\u1ed3n n\u00f4n, n\u00f4n do h\u00f3a tr\u1ecb \u1edf tr\u1ebb em &gt; 6 th\u00e1ng tu\u1ed5i v\u00e0 thi\u1ebfu ni\u00ean<\/p>\n<table>\n<tbody>\n<tr>\n<td><strong>Di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t c\u01a1 th\u1ec3<\/strong><\/td>\n<td><strong>Ng\u00e0y 1\u00a0<sup>(a,b)<\/sup><\/strong><\/td>\n<td><strong>Ng\u00e0y 2-6<sup>(b)<\/sup><\/strong><\/td>\n<\/tr>\n<tr>\n<td>&lt; 0.6 m<sup>2<\/sup><\/td>\n<td>5 mg\/m<sup>2<\/sup>\u00a0i.v. k\u1ebft h\u1ee3p sau 2mg sau 12 gi\u1edd<\/td>\n<td>2 mg sir\u00f4 m\u1ed7i 12 gi\u1edd<\/td>\n<\/tr>\n<tr>\n<td>\u2265 0.6 m<sup>2<\/sup><\/td>\n<td>5 mg\/ m<sup>2<\/sup>i.v. k\u1ebft h\u1ee3p sir\u00f4 ho\u1eb7c vi\u00ean n\u00e9n 4 mg sau 12 gi\u1edd<\/td>\n<td>4 mg sir\u00f4 ho\u1eb7c vi\u00ean n\u00e9n m\u1ed7i 12 gi\u1edd<\/td>\n<\/tr>\n<tr>\n<td>\u2265 1.2 m<sup>2<\/sup><\/td>\n<td>8 mg i.v. k\u1ebft h\u1ee3p sir\u00f4 ho\u1eb7c vi\u00ean n\u00e9n 8 mg sau 12 gi\u1edd<\/td>\n<td>8 mg sir\u00f4 ho\u1eb7c vi\u00ean n\u00e9n m\u1ed7i 12gi\u1edd<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>a: Li\u1ec1u ti\u00eam t\u0129nh m\u1ea1ch kh\u00f4ng qu\u00e1 8 mg.<\/p>\n<p>b: T\u0103ng li\u1ec1u m\u1ed9t ng\u00e0y kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 li\u1ec1u ng\u01b0\u1eddi l\u1edbn 32 mg.<\/p>\n<p><em>Li\u1ec1u t\u00ednh theo th\u1ec3 tr\u1ecdng:<\/em><\/p>\n<p>Ondansetron \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ngay tr\u01b0\u1edbc khi h\u00f3a tr\u1ecb d\u00f9ng li\u1ec1u duy nh\u1ea5t ti\u00eam t\u0129nh m\u1ea1ch 0,15 mg\/kg. Li\u1ec1u ti\u00eam t\u0129nh m\u1ea1ch kh\u00f4ng \u0111\u01b0\u1ee3c v\u01b0\u1ee3t qu\u00e1 8 mg.<\/p>\n<p>C\u00f3 th\u1ec3 s\u1eed d\u1ee5ng th\u00eam 2 li\u1ec1u ti\u00eam t\u0129nh m\u1ea1ch n\u1eefa, m\u1ed7i li\u1ec1u c\u00e1ch nhau 4 gi\u1edd. T\u1ed5ng li\u1ec1u h\u00e0ng ng\u00e0y kh\u00f4ng \u0111\u01b0\u1ee3c v\u01b0\u1ee3t qu\u00e1 32 mg.<\/p>\n<p>Li\u1ec1u u\u1ed1ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh sau \u0111\u00f3 12 gi\u1edd v\u00e0 c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng li\u00ean t\u1ee5c trong 5 ng\u00e0y (xem b\u1ea3ng 2).<\/p>\n<p>B\u1ea3ng 2: Li\u1ec1u t\u00ednh theo th\u1ec3 tr\u1ecdng \u0111\u1ed1i v\u1edbi bu\u1ed3n n\u00f4n, n\u00f4n m\u1eefa do h\u00f3a tr\u1ecb \u1edf tr\u1ebb em &gt; 6 th\u00e1ng tu\u1ed5i v\u00e0 thi\u1ebfu ni\u00ean<\/p>\n<table>\n<tbody>\n<tr>\n<td><strong>Kh\u1ed1i l\u01b0\u1ee3ng<\/strong><\/td>\n<td><strong>Ng\u00e0y 1\u00a0<sup>(a,b)<\/sup><\/strong><\/td>\n<td><strong>Ng\u00e0y 2-6\u00a0<sup>(b)<\/sup><\/strong><\/td>\n<\/tr>\n<tr>\n<td>\u2264 10 kg<\/td>\n<td>T\u1ed1i \u0111a 3 li\u1ec1u 0,15 mg\/kg m\u1ed7i 4 gi\u1edd<\/td>\n<td>Sir\u00f4 2 mg m\u1ed7i 12 gi\u1edd<\/td>\n<\/tr>\n<tr>\n<td>&gt; 10 kg<\/td>\n<td>T\u1ed1i \u0111a 3 li\u1ec1u 0,15 mg\/kg m\u1ed7i 4 gi\u1edd<\/td>\n<td>Sir\u00f4 ho\u1eb7c vi\u00ean n\u00e9n 4 mg m\u1ed7i 12 gi\u1edd<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>a: Li\u1ec1u ti\u00eam t\u0129nh m\u1ea1ch kh\u00f4ng qu\u00e1 8 mg.<\/p>\n<p>b: T\u1ed5ng li\u1ec1u m\u1ed9t ng\u00e0y kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 li\u1ec1u ng\u01b0\u1eddi l\u1edbn 32 mg<\/p>\n<p>Ondansetron n\u00ean \u0111\u01b0\u1ee3c pha lo\u00e3ng trong dung d\u1ecbch dextrose 5% ho\u1eb7c NaCl 0,9% ho\u1eb7c c\u00e1c dung d\u1ecbch ti\u00eam truy\u1ec1n t\u01b0\u01a1ng th\u00edch kh\u00e1c v\u00e0 truy\u1ec1n t\u0129nh m\u1ea1ch trong th\u1eddi gian kh\u00f4ng du\u1edbi 15 ph\u00fat.<\/p>\n<p><em>Bu\u1ed3n n\u00f4n, n\u00f4n h\u1eadu ph\u1eabu (PONV) \u1edf ng\u01b0\u1eddi l\u1edbn<\/em><\/p>\n<p><em>D\u1ef1 ph\u00f2ng bu\u1ed3n n\u00f4n, n\u00f4n h\u1eadu ph\u1eabu<\/em><\/p>\n<p>\u0110\u1ec3 d\u1ef1 ph\u00f2ng bu\u1ed3n n\u00f4n, n\u00f4n sau ph\u1eabu thu\u1eadt, li\u1ec1u ondansetron khuy\u1ebfn c\u00e1o qua \u0111u\u1eddng t\u0129nh m\u1ea1ch l\u00e0 4 mg ti\u00eam t\u0129nh m\u1ea1ch ch\u1eadm khi kh\u1edfi m\u00ea.<\/p>\n<p><em>\u0110i\u1ec1u tr\u1ecb bu\u1ed3n n\u00f4n, n\u00f4n h\u1eadu ph\u1eabu<\/em><\/p>\n<p>\u0110\u1ec3 \u0111i\u1ec1u tr\u1ecb bu\u1ed3n n\u00f4n, n\u00f4n sau ph\u1eabu thu\u1eadt, ti\u00eam t\u0129nh m\u1ea1ch ch\u1eadm 4 mg.<\/p>\n<p><em>Li\u1ec1u d\u00f9ng tr\u00ean nh\u00f3m d\u00e2n s\u1ed1 \u0111\u1eb7c bi\u1ec7t:<\/em><\/p>\n<p><em>B\u1ec7nh nh\u00e2n suy th\u1eadn:<\/em><\/p>\n<p>Kh\u00f4ng c\u1ea7n hi\u1ec7u ch\u1ec9nh li\u1ec1u h\u00e0ng ng\u00e0y v\u00e0 s\u1ed1 l\u1ea7n s\u1eed d\u1ee5ng c\u0169ng nh\u01b0 \u0111\u01b0\u1eddng s\u1eed d\u1ee5ng.<\/p>\n<p><em>B\u1ec7nh nh\u00e2n suy gan:<\/em><\/p>\n<p>S\u1ef1 thanh th\u1ea3i c\u1ee7a ondansetron b\u1ecb gi\u1ea3m v\u00e0 th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a thu\u1ed1c k\u00e9o d\u00e0i \u1edf c\u00e1c b\u1ec7nh nh\u00e2n suy gan m\u1ee9c \u0111\u1ed9 trung b\u00ecnh \u0111\u1ebfn n\u1eb7ng, \u1edf c\u00e1c b\u1ec7nh nh\u00e2n n\u00e0y, kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng t\u1ed5ng li\u1ec1u h\u00e0ng ng\u00e0y v\u01b0\u1ee3t qu\u00e1 8 mg.<\/p>\n<p><em>B\u1ec7nh nh\u00e2n chuy\u1ec3n h\u00f3a k\u00e9m spartein\/debrisoquin:<\/em><\/p>\n<p>Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a ondansetron kh\u00f4ng b\u1ecb thay \u0111\u1ed5i \u1edf c\u00e1c b\u1ec7nh nh\u00e2n k\u00e9m chuy\u1ec3n h\u00f3a spartein v\u00e0 debrisoquin. \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y, khi s\u1eed d\u1ee5ng li\u1ec1u l\u1eb7p l\u1ea1i ondansetron kh\u00f4ng l\u00e0m thay \u0111\u1ed5i t\u1ed5ng lu\u1ee3ng thu\u1ed1c trong tu\u1ea7n ho\u00e0n so v\u1edbi ngu\u1eddi b\u00ecnh thu\u1eddng, v\u00ec th\u1ebf kh\u00f4ng c\u1ea7n ph\u1ea3i hi\u1ec7u ch\u1ec9nh li\u1ec1u h\u00e0ng ng\u00e0y ho\u1eb7c s\u1ed1 l\u1ea7n s\u1eed d\u1ee5ng.<\/p>\n<p><em>B\u1ec7nh nh\u00e2n cao tu\u1ed5i:<\/em><\/p>\n<p>Kinh nghi\u1ec7m s\u1eed d\u1ee5ng ondansetron trong d\u1ef1 ph\u00f2ng v\u00e0 \u0111i\u1ec1u tr\u1ecb bu\u1ed3n n\u00f4n, n\u00f4n h\u1eadu ph\u1eabu \u1edf b\u1ec7nh nh\u00e2n cao tu\u1ed5i c\u00f2n h\u1ea1n ch\u1ebf, tuy nhi\u00ean ondansetron \u0111\u01b0\u1ee3c dung n\u1ea1p t\u1ed1t \u1edf c\u00e1c b\u1ec7nh nh\u00e2n tr\u00ean 65 tu\u1ed5i \u0111ang \u0111\u01b0\u1ee3c h\u00f3a tr\u1ecb.<\/p>\n<p><em>Bu\u1ed3n n\u00f4n, n\u00f4n h\u1eadu ph\u1eabu \u1edf tr\u1ebb &gt;1 th\u00e1ng tu\u1ed5i v\u00e0 thi\u1ebfu ni\u00ean<\/em><\/p>\n<p>D\u1ef1 ph\u00f2ng bu\u1ed3n n\u00f4n, n\u00f4n h\u1eadu ph\u1eabu \u1edf tr\u1ebb em ph\u1eabu thu\u1eadt th\u1ef1c hi\u1ec7n g\u00e2y m\u00ea t\u1ed5ng qu\u00e1t, d\u00f9ng li\u1ec1u duy nh\u1ea5t ondansetron 0,1 mg\/kg, t\u1ed1i \u0111a 4 mg, ti\u00eam t\u0129nh m\u1ea1ch ch\u1eadm (kh\u00f4ng d\u01b0\u1edbi 30 gi\u00e2y), tr\u01b0\u1edbc ho\u1eb7c ngay khi kh\u1edfi m\u00ea.<\/p>\n<p>\u0110\u1ec3 \u0111i\u1ec1u tr\u1ecb bu\u1ed3n n\u00f4n, n\u00f4n h\u1eadu ph\u1eabu \u1edf tr\u1ebb em ph\u1eabu thu\u1eadt th\u1ef1c hi\u1ec7n g\u00e2y m\u00ea t\u1ed5ng qu\u00e1t, d\u00f9ng li\u1ec1u duy nh\u1ea5t ondansetron 0,1 mg\/kg, t\u1ed1i \u0111a 4 mg, ti\u00eam t\u0129nh m\u1ea1ch ch\u1eadm (kh\u00f4ng d\u01b0\u1edbi 30 gi\u00e2y).<\/p>\n<p><strong>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>Qu\u00e1 m\u1eabn v\u1edbi b\u1ea5t k\u1ef3 thu\u1ed1c \u0111\u1ed1i kh\u00e1ng 5-HT3 n\u00e0o kh\u00e1c.<\/p>\n<p>S\u1eed d\u1ee5ng c\u00f9ng l\u00fac v\u1edbi apomorphin (xem m\u1ee5c T\u01b0\u01a1ng t\u00e1c c\u1ee7a thu\u1ed1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c v\u00e0 c\u00e1c lo\u1ea1i t\u01b0\u01a1ng t\u00e1c kh\u00e1c)<\/p>\n<p>M\u1eabn c\u1ea3m v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c<\/p>\n<p><strong>4.4 Th\u1eadn tr\u1ecdng:<\/strong><\/p>\n<p>Ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn \u1edf c\u00e1c b\u1ec7nh nh\u00e2n c\u00f3 bi\u1ec3u hi\u1ec7n qu\u00e1 m\u1eabn \u0111\u1ed1i v\u1edbi c\u00e1c thu\u1ed1c \u0111\u1ed1i kh\u00e1ng ch\u1ecdn l\u1ecdc th\u1ee5 th\u1ec3 5-HT3.<\/p>\n<p>C\u00e1c bi\u1ebfn c\u1ed1 tr\u00ean h\u00f4 h\u1ea5p c\u1ea7n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb theo tri\u1ec7u ch\u1ee9ng v\u00e0 b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb c\u1ea7n \u0111\u1eb7c bi\u1ec7t ch\u00fa \u00fd v\u00ec \u0111\u00f3 l\u00e0 ti\u1ec1n th\u00e2n c\u1ee7a ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn.<\/p>\n<p>Ondansetron k\u00e9o d\u00e0i kho\u1ea3ng QT t\u00f9y thu\u1ed9c v\u00e0o li\u1ec1u l\u01b0\u1ee3ng s\u1eed d\u1ee5ng. Ngo\u00e0i ra, c\u00e1c theo d\u00f5i sau khi l\u01b0u h\u00e0nh thu\u1ed1c c\u0169ng \u0111\u00e3 ghi nh\u1eadn c\u00e1c tr\u01b0\u1eddng h\u1ee3p b\u1ecb xo\u1eafn \u0111\u1ec9nh (Torsade de Point) tr\u00ean b\u1ec7nh nh\u00e2n d\u00f9ng Ondansetron. Tr\u00e1nh s\u1eed d\u1ee5ng ondansetron \u1edf c\u00e1c b\u1ec7nh nh\u00e2n c\u00f3 h\u1ed9i ch\u1ee9ng k\u00e9o d\u00e0i kho\u1ea3ng QT b\u1ea9m sinh, c\u1ea7n th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng ondansetron \u1edf c\u00e1c b\u1ec7nh nh\u00e2n c\u00f3 ho\u1eb7c c\u00f3 th\u1ec3 kh\u1edfi ph\u00e1t k\u00e9o d\u00e0i kho\u1ea3ng QT, g\u1ed3m c\u00e1c b\u1ec7nh nh\u00e2n c\u00f3 b\u1ea5t th\u01b0\u00f2ng \u0111i\u1ec7n gi\u1ea3i, suy tim sung huy\u1ebft, ch\u1eadm nh\u1ecbp tim ho\u1eb7c b\u1ec7nh nh\u00e2n \u0111ang s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c g\u00e2y k\u00e9o d\u00e0i QT ho\u1eb7c b\u1ea5t th\u01b0\u1eddng \u0111i\u1ec7n gi\u1ea3i.<\/p>\n<p>C\u1ea7n ph\u1ea3i hi\u1ec7u ch\u1ec9nh c\u00e1c tr\u01b0\u1eddng h\u1ee3p h\u1ea1 kali v\u00e0 h\u1ea1 magie huy\u1ebft tr\u01b0\u1edbc khi ch\u1ec9 \u0111\u1ecbnh ondansetron.<\/p>\n<p>\u0110\u00e3 c\u00f3 b\u00e1o c\u00e1o sau khi thu\u1ed1c l\u01b0u h\u00e0nh v\u1ec1 h\u1ed9i ch\u1ee9ng serotonin x\u1ea3y ra \u1edf b\u1ec7nh nh\u00e2n (bao g\u1ed3m thay \u0111\u1ed5i tr\u1ea1ng th\u00e1i tinh th\u1ea7n, b\u1ea5t \u1ed5n v\u1ec1 th\u1ea7n kinh t\u1ef1 \u0111\u1ed9ng v\u00e0 th\u1ea7n kinh c\u01a1) sau khi s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi ondansetron v\u00e0 c\u00e1c thu\u1ed1c t\u00e1c \u0111\u1ed9ng tr\u00ean h\u1ec7 serotonin kh\u00e1c (g\u1ed3m nh\u00f3m \u1ee9c ch\u1ebf t\u00e1i h\u1ea5p thu c\u00f3 ch\u1ecdn l\u1ecdc serotonin &#8211; SSRI ho\u1eb7c \u1ee9c ch\u1ebf t\u00e1i h\u1ea5p thu serotonin-noradrenalin &#8211; SNRIs). N\u1ebfu b\u1eaft bu\u1ed9c ph\u1ea3i s\u1eed d\u1ee5ng c\u00f9ng l\u00fac c\u00e1c thu\u1ed1c tr\u00ean, c\u1ea7n ph\u1ea3i theo d\u00f5i b\u1ec7nh nh\u00e2n ch\u1eb7t ch\u1ebd<\/p>\n<p>Do ondansetron l\u00e0m t\u0103ng nhu \u0111\u1ed9ng ru\u1ed9t gi\u00e0, c\u1ea7n ph\u1ea3i theo d\u00f5i c\u1ea9n th\u1eadn b\u1ec7nh nh\u00e2n c\u00f3 d\u1ea5u hi\u1ec7u t\u1eafc ru\u1ed9t b\u00e1n c\u1ea5p.<\/p>\n<p>\u1ede b\u1ec7nh nh\u00e2n ph\u1eabu thu\u1eadt c\u1eaft amidan, d\u00f9ng ondansetron \u0111\u1ec3 d\u1ef1 ph\u00f2ng bu\u1ed3n n\u00f4n, n\u00f4n c\u00f3 th\u1ec3 che gi\u1ea5u tr\u00ecnh tr\u1ea1ng ch\u1ea3y m\u00e1u, v\u00ec th\u1ebf c\u1ea7n theo d\u00f5i c\u1ea9n th\u1eadn b\u1ec7nh nh\u00e2n sau khi s\u1eed d\u1ee5ng ondansetron.<\/p>\n<p><em>B\u1ec7nh nh\u00e2n nhi:<\/em><\/p>\n<p>C\u1ea7n theo d\u00f5i ch\u1eb7t ch\u1ebd s\u1ef1 suy gi\u1ea3m ch\u1ee9c n\u0103ng gan \u1edf b\u1ec7nh nh\u00e2n nhi s\u1eed d\u1ee5ng ondansetron khi \u0111\u01b0\u1ee3c h\u00f3a tr\u1ecb v\u1edbi c\u00e1c thu\u1ed1c g\u00e2y \u0111\u1ed9c t\u00ednh tr\u00ean gan.<\/p>\n<p><em>Bu\u1ed3n n\u00f4n, n\u00f4n do h\u00f3a tr\u1ecb:<\/em><\/p>\n<p>Khi t\u00ednh li\u1ec1u theo mg\/kg th\u1ec3 tr\u1ecdng v\u00e0 s\u1eed d\u1ee5ng 3 li\u1ec1u c\u00e1ch nhau m\u1ed7i 4 gi\u1edd, t\u1ed5ng li\u1ec1u s\u1eed d\u1ee5ng h\u00e0ng ng\u00e0y s\u1ebd cao h\u01a1n khi s\u1eed d\u1ee5ng li\u1ec1u \u0111\u01a1n 5 mg\/m2, sau \u0111\u00f3 d\u00f9ng th\u00eam 1 li\u1ec1u u\u1ed1ng. Hi\u1ec7u qu\u1ea3 gi\u1eefa 2 c\u00e1ch s\u1eed d\u1ee5ng n\u00e0y ch\u01b0a \u0111\u01b0\u1ee3c so s\u00e1nh trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng. Th\u1eed nghi\u1ec7m ch\u00e9o cho th\u1ea5y hi\u1ec7u qu\u1ea3 c\u1ee7a 2 c\u00e1ch s\u1eed d\u1ee5ng tr\u00ean l\u00e0 nh\u01b0 nhau .<\/p>\n<p>S\u1ea3n ph\u1ea9m n\u00e0y ch\u1ee9a 2,3 mmol (hay 53,5 mg) natri cho m\u1ed7i li\u1ec1u, c\u1ea7n l\u01b0u \u00fd khi s\u1eed d\u1ee5ng cho b\u1ec7nh nh\u00e2n c\u00f3 ch\u1ebf \u0111\u1ed9 \u0103n ki\u1ec3m so\u00e1t natri.<\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>C\u00e1c th\u1eed nghi\u1ec7m cho th\u1ea5y ondansetron kh\u00f4ng l\u00e0m suy gi\u1ea3m ch\u1ee9c n\u0103ng v\u1eadn \u0111\u1ed9ng c\u0169ng nh\u01b0 kh\u00f4ng g\u00e2y an th\u1ea7n. Ondansetron kh\u00f4ng g\u00e2y t\u00e1c \u0111\u1ed9ng c\u00f3 h\u1ea1i \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/strong><\/p>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: B1<\/p>\n<p>US FDA pregnancy category: B<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>Ch\u01b0a x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c t\u00ednh an to\u00e0n c\u1ee7a ondansetron khi s\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef \u0111ang mang thai. \u0110\u00e1nh gi\u00e1 t\u1eeb c\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt kh\u00f4ng cho th\u1ea5y ondansetron g\u00e2y t\u00e1c \u0111\u1ed9ng c\u00f3 h\u1ea1i tr\u1ef1c ti\u1ebfp hay gi\u00e1n ti\u1ebfp tr\u00ean s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a b\u00e0o thai, qu\u00e1 tr\u00ecnh mang thai v\u00e0 qu\u00e1 tr\u00ecnh ph\u00e1t tri\u1ec3n trong th\u1eddi k\u1ef3 mang thai ho\u1eb7c sau khi sinh. Tuy nhi\u00ean c\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt kh\u00f4ng ho\u00e0n to\u00e0n gi\u00fap ti\u00ean \u0111o\u00e1n \u0111\u00e1p \u1ee9ng tr\u00ean ng\u01b0\u1eddi, v\u00ec th\u1ebf, kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng ondansetron cho ph\u1ee5 n\u1eef c\u00f3 thai<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>C\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y ondansetron qua \u0111\u01b0\u1ee3c s\u1eefa. V\u00ec v\u1eady, khuy\u1ebfn c\u00e1o ph\u1ee5 n\u1eef \u0111ang s\u1eed d\u1ee5ng ondansetron kh\u00f4ng n\u00ean cho con b\u00fa.<\/p>\n<p><strong>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/strong><\/p>\n<p>C\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n d\u01b0\u1edbi \u0111\u00e2y \u0111\u01b0\u1ee3c li\u1ec7t k\u00ea theo h\u1ec7 c\u01a1 quan v\u00e0 t\u1ea7n su\u1ea5t xu\u1ea5t hi\u1ec7n. T\u1ea7n su\u1ea5t \u0111\u01b0\u1ee3c \u0111\u1ecbnh ngh\u0129a nh\u01b0 sau: r\u1ea5t th\u01b0\u1eddng x\u1ea3y ra (&gt;1\/10), th\u01b0\u1eddng x\u1ea3y ra (&gt;1\/100 \u0111\u1ebfn &lt;1\/10), \u00edt khi x\u1ea3y ra (&gt;1\/1000 \u0111\u1ebfn &lt;1\/100), hi\u1ebfm khi x\u1ea3y ra (&gt;1\/10000 \u0111\u1ebfn &lt;1\/1000) v\u00e0 r\u1ea5t hi\u1ebfm khi x\u1ea3y ra (&lt;1\/10000). C\u00e1c t\u00e1c \u0111\u1ed9ng b\u1ea5t l\u1ee3i r\u1ea5t th\u01b0\u1eddng x\u1ea3y ra, th\u01b0\u1eddng x\u1ea3y ra v\u00e0 \u00edt khi x\u1ea3y ra \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh t\u1eeb d\u1eef li\u1ec7u th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng c\u00f3 t\u00ednh \u0111\u1ebfn t\u1ea7n su\u1ea5t t\u01b0\u01a1ng t\u1ef1 \u1edf nh\u00f3m s\u1eed d\u1ee5ng gi\u1ea3 d\u01b0\u1ee3c. C\u00e1c t\u00e1c \u0111\u1ed9ng b\u1ea5t l\u1ee3i hi\u1ebfm v\u00e0 r\u1ea5t hi\u1ebfm khi x\u1ea3y ra \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh t\u1eeb d\u1eef li\u1ec7u b\u00e1o c\u00e1o sau khi thu\u1ed1c l\u01b0u h\u00e0nh.<\/p>\n<p>T\u1ea7n xu\u1ea5t x\u1ea3y ra c\u00e1c t\u00e1c \u0111\u1ed9ng b\u1ea5t l\u1ee3i d\u01b0\u1edbi \u0111\u00e2y \u0111\u01b0\u1ee3c \u01b0\u1edbc t\u00ednh \u1edf li\u1ec1u khuy\u1ebfn c\u00e1o chu\u1ea9n c\u1ee7a ondansetron theo ch\u1ec9 \u0111\u1ecbnh v\u00e0 d\u1ea1ng b\u00e0o ch\u1ebf.<\/p>\n<p><em>R\u1ed1i lo\u1ea1n h\u1ec7 mi\u1ec5n d\u1ecbch<\/em><\/p>\n<p>Hi\u1ebfm khi x\u1ea3y ra: ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn t\u1ee9c th\u1eddi, \u0111\u00f4i khi nghi\u00eam tr\u1ecdng, bao g\u1ed3m c\u1ea3 s\u1ed1c ph\u1ea3n v\u1ec7<\/p>\n<p><em>R\u1ed1i lo\u1ea1n h\u1ec7 th\u1ea7n kinh<\/em><\/p>\n<p>R\u1ea5t th\u01b0\u1eddng x\u1ea3y ra: \u0111au \u0111\u1ea7u<\/p>\n<p>\u00edt khi x\u1ea3y ra: co gi\u1eadt, r\u1ed1i lo\u1ea1n v\u1eadn \u0111\u1ed9ng (bao g\u1ed3m c\u00e1c ph\u1ea3n \u1ee9ng ngo\u1ea1i th\u00e1p nh\u01b0 co c\u1ee9ng, lo\u1ea1n v\u1eadn nh\u00e3n v\u00e0 lo\u1ea1n v\u1eadn \u0111\u1ed9ng)1<\/p>\n<p>Hi\u1ebfm khi x\u1ea3y ra: ch\u00f3ng m\u1eb7t khi ti\u00eam t\u0129nh m\u1ea1ch nhanh<\/p>\n<p>R\u1ea5t hi\u1ebfm khi x\u1ea3y ra: tr\u1ea7m c\u1ea3m<\/p>\n<p><em>R\u1ed1i lo\u1ea1n m\u1ea5t<\/em><\/p>\n<p>Hi\u1ebfm khi x\u1ea3y ra: r\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c tho\u00e1ng qua (nh\u00ecn m\u1edd), ch\u1ee7 y\u1ebfu khi s\u1eed d\u1ee5ng qua \u0111\u01b0\u1eddng ti\u00eam t\u0129nh m\u1ea1ch<\/p>\n<p>R\u1ea5t hi\u1ebfm khi x\u1ea3y ra: m\u00f9 tho\u00e1ng qua, ch\u1ee7 y\u1ebfu x\u1ea3y ra khi s\u1eed d\u1ee5ng qua \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch2<\/p>\n<p><em>R\u1ed1i lo\u1ea1n \u1edf tim<\/em><\/p>\n<p>R\u1ea5t \u00edt khi x\u1ea3y ra: lo\u1ea1n nh\u1ecbp, \u0111au ng\u1ef1c kh\u00f4ng ho\u1eb7c c\u00f3 k\u00e8m theo gi\u1ea3m \u0111o\u1ea1n ST, ch\u1eadm nh\u1ecbp tim<\/p>\n<p>Hi\u1ebfm khi x\u1ea3y ra: k\u00e9o d\u00e0i kho\u1ea3ng QT (k\u1ec3 c\u1ea3 xo\u1eafn \u0111\u1ec9nh)<\/p>\n<p><em>R\u1ed1i lo\u1ea1n \u1edf m\u1ea1ch<\/em><\/p>\n<p>Th\u01b0\u1eddng x\u1ea3y ra: c\u1ea3m gi\u00e1c n\u00f3ng ho\u1eb7c \u0111\u1ecf<\/p>\n<p>\u00edt khi x\u1ea3y ra: t\u1ee5t huy\u1ebft \u00e1p<\/p>\n<p><em>R\u1ed1i lo\u1ea1n h\u00f4 h\u1ea5p, l\u1ed3ng ng\u1ef1c v\u00e0 trung th\u1ea5t<\/em><\/p>\n<p>\u00edt khi x\u1ea3y ra: n\u1ea5c c\u1ee5t<\/p>\n<p><em>R\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a<\/em><\/p>\n<p>Th\u01b0\u1eddng x\u1ea3y ra: t\u00e1o b\u00f3n<\/p>\n<p><em>C\u00e1c r\u1ed1i lo\u1ea1n \u1edf gan<\/em><\/p>\n<p>\u00edt khi x\u1ea3y ra: t\u0103ng men gan kh\u00f4ng tri\u1ec7u ch\u1ee9ng trong x\u00e9t nghi\u1ec7m ch\u1ee9c n\u0103ng gan3<\/p>\n<p><em>R\u1ed1i lo\u1ea1n t\u1ed3ng qu\u00e1t v\u00e0 t\u1ea1i v\u1ecb tr\u00ed ti\u00eam<\/em><\/p>\n<p>Th\u01b0\u00f2ng x\u1ea3y ra: ph\u1ea3n \u1ee9ng t\u1ea1i ch\u1ed7 t\u1ea1i n\u01a1i ti\u00eam<\/p>\n<p>(1). Quan s\u00e1t \u0111\u01b0\u1ee3c nh\u01b0ng kh\u00f4ng c\u00f3 b\u1eb1ng ch\u1ee9ng r\u00f5 r\u00e0ng v\u1ec1 di ch\u1ee9ng l\u00e2m s\u00e0ng dai d\u1eafng<\/p>\n<p>(2). Ph\u1ea7n l\u1edbn c\u00e1c tr\u01b0\u1eddng h\u1ee3p b\u1ecb m\u00f9 \u0111\u01b0\u1ee3c ghi nh\u1eadn s\u1ebd h\u1ebft trong v\u00f2ng 20 ph\u00fat. H\u1ea7u h\u1ebft c\u00e1c b\u1ec7nh nh\u00e2n n\u00e0y \u0111\u1ec1u c\u00f3 s\u1eeb d\u1ee5ng c\u00e1c thu\u1ed1c h\u00f3a tr\u1ecb bao g\u1ed3m c\u1ea3 cisplatin. M\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p m\u00f9 tho\u00e1ng qua \u0111\u01b0\u1ee3c ghi nh\u1eadn l\u00e0 do nguy\u00ean nh\u00e2n t\u1eeb v\u1ecf n\u00e3o.<\/p>\n<p>(3). Nh\u1eefng bi\u1ebfn c\u1ed1 b\u1ea5t l\u1ee3i n\u00e0y th\u01b0\u1eddng th\u1ea5y \u1edf b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c h\u00f3a tr\u1ecb b\u1eb1ng cisplatin<\/p>\n<p><em>B\u1ec7nh nh\u00e2n nhi<\/em><\/p>\n<p>C\u00e1c bi\u1ebfn c\u1ed1 b\u1ea5t l\u1ee3i \u1edf tr\u1ebb em v\u00e0 thi\u1ebfu ni\u00ean l\u00e0 t\u01b0\u01a1ng t\u1ef1 nh\u01b0 \u1edf ng\u01b0\u1eddi l\u1edbn<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<p><strong>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/strong><\/p>\n<p>Ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c. V\u1edbi c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i nh\u1eb9, th\u01b0\u1eddng ch\u1ec9 c\u1ea7n ng\u1eebng thu\u1ed1c. Tr\u01b0\u1eddng h\u1ee3p m\u1eabn c\u1ea3m n\u1eb7ng ho\u1eb7c ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, c\u1ea7n ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 (gi\u1eef tho\u00e1ng kh\u00ed v\u00e0 d\u00f9ng epinephrin, th\u1edf oxygen, d\u00f9ng kh\u00e1ng histamin, corticoid&#8230;).<\/p>\n<p><strong>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/strong><\/p>\n<p>Kh\u00f4ng c\u00f3 b\u1eb1ng ch\u1ee9ng cho th\u1ea5y ondansetron g\u00e2y c\u1ea3m \u1ee9ng hay \u1ee9c ch\u1ebf s\u1ef1 chuy\u1ec3n h\u00f3a c\u1ee7a c\u00e1c thu\u1ed1c th\u01b0\u1eddng s\u1eed d\u1ee5ng chung v\u1edbi n\u00f3. C\u00e1c nghi\u00ean c\u1ee9u c\u1ee5 th\u1ec3 cho th\u1ea5y kh\u00f4ng c\u00f3 t\u01b0\u01a1ng t\u00e1c khi s\u1eed d\u1ee5ng ondansetron c\u00f9ng v\u1edbi r\u01b0\u1ee3u, temazepam, furosemid, alfentanil, tramadol, morphin, lignocain, thiopental hay propofol.<\/p>\n<p>Ondansetron \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1edfi h\u1ec7 enzym cytochrom P450 nh\u01b0 CYP3A4, CYP2D6 v\u00e0 CYP1A2. Do c\u00f3 nhi\u1ec1u enzym tham gia v\u00e0o chuy\u1ec3n h\u00f3a ondansetron, s\u1ef1 \u1ee9c ch\u1ebf hay gi\u1ea3m ho\u1ea1t t\u00ednh c\u1ee7a m\u1ed9t enzym chuy\u1ec3n h\u00f3a (v\u00ed d\u1ee5 khi\u1ebfm khuy\u1ebft di truy\u1ec1n CYP2D6) th\u01b0\u1eddng s\u1ebd \u0111\u01b0\u1ecdc b\u00f9 tr\u1eeb b\u1edfi c\u00e1c enzym chuy\u1ec3n h\u00f3a kh\u00e1c v\u00e0 v\u00ec th\u1ebf, kh\u00f4ng l\u00e0m thay \u0111\u1ed5i ho\u1eb7c thay \u0111\u1ed5i r\u1ea5t \u00edt s\u1ef1 thanh th\u1ea3i t\u1ed5ng th\u1ec3 c\u1ee7a ondansetron ho\u1eb7c li\u1ec1u s\u1eed d\u1ee5ng.<\/p>\n<p>S\u1eed d\u1ee5ng ondansetron c\u00f9ng v\u1edbi c\u00e1c thu\u1ed1c g\u00e2y k\u00e9o d\u00e0i kho\u1ea3ng QT c\u00f3 th\u1ec3 l\u00e0m k\u00e9o d\u00e0i th\u00eam QT. S\u1eed d\u1ee5ng ondansetron c\u00f9ng v\u1edbi c\u00e1c thu\u1ed1c g\u00e2y \u0111\u1ed9c t\u00ednh tr\u00ean tim (v\u00ed d\u1ee5 c\u00e1c thu\u1ed1c nh\u00f3m anthracyclin nh\u01b0 doxorubicin, daunorubicin hay trastuzumab), c\u00e1c kh\u00e1ng sinh (erythromycin hay ketoconazol), thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp (amiodaron) v\u00e0 thu\u1ed1c ch\u1eb9n beta (atenolol hay timolol) c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 lo\u1ea1n nh\u1ecbp (xem m\u1ee5c C\u00e1c tr\u01b0\u1eddng h\u1ee3p th\u1eadn tr\u1ecdng khi d\u00f9ng thu\u1ed1c).<\/p>\n<p>\u0110\u00e3 c\u00f3 b\u00e1o c\u00e1o sau khi thu\u1ed1c l\u01b0u h\u00e0nh v\u1ec1 h\u1ed9i ch\u1ee9ng serotonin (thay \u0111\u1ed5i tr\u1ea1ng th\u00e1i tinh th\u1ea7n, b\u1ea5t \u1ed5n v\u1ec1 th\u1ea7n kinh t\u1ef1 \u0111\u1ed9ng v\u00e0 th\u1ea7n kinh c\u01a1) x\u1ea3y ra \u1edf b\u1ec7nh nh\u00e2n sau khi s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi ondansetron v\u00e0 c\u00e1c thu\u1ed1c t\u00e1c \u0111\u1ed9ng tr\u00ean serotonin kh\u00e1c (nh\u00f3m \u1ee9c ch\u1ebf t\u00e1i h\u1ea5p thu c\u00f3 ch\u1ecdn l\u1ecdc serotonin SSRI ho\u1eb7c \u1ee9c ch\u1ebf t\u00e1i h\u1ea5p thu serotonin-noradrenalin SNRIs) (xem m\u1ee5c C\u00e1c tr\u01b0\u1eddng h\u1ee3p th\u1eadn tr\u1ecdng khi d\u00f9ng thu\u1ed1c).<\/p>\n<p><em>Apomorphin<\/em><\/p>\n<p>C\u0103n c\u1ee9 tr\u00ean c\u00e1c b\u00e1o c\u00e1o v\u1ec1 t\u00ecnh tr\u1ea1ng t\u1ee5t huy\u1ebft \u00e1p r\u00f5 r\u1ec7t v\u00e0 m\u1ea5t \u00fd th\u1ee9c khi s\u1eed d\u1ee5ng ondansetron v\u1edbi apomorphin hydroclorid, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng ondansetron c\u00f9ng l\u00fac v\u1edbi apomorphin.<\/p>\n<p><em>Phenytoin, carbamazepin v\u00e0 rifampicin<\/em><\/p>\n<p>\u1ede c\u00e1c b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1edfi c\u00e1c ch\u1ea5t g\u00e2y c\u1ea3m \u1ee9ng m\u1ea1nh CYP3A4 (phenytoin, carbamazepin v\u00e0 rifampicin), s\u1ef1 thanh th\u1ea3i c\u1ee7a ondansetron khi s\u1eed d\u1ee5ng \u0111\u01b0\u00f2ng u\u1ed1ng t\u0103ng v\u00e0 n\u1ed3ng \u0111\u1ed9 ondansetron trong m\u00e1u gi\u1ea3m.<\/p>\n<p><em>Tramadol<\/em><\/p>\n<p>D\u1eef li\u1ec7u t\u1eeb c\u00e1c nghi\u00ean c\u1ee9u nh\u1ecf cho th\u1ea5y ondansetron c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 gi\u1ea3m \u0111au c\u1ee7a tramadol<\/p>\n<p><strong>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/strong><\/p>\n<p><em>D\u1ea5u hi\u1ec7u v\u00e0 tri\u1ec7u ch\u1ee9ng<\/em><\/p>\n<p>Kinh nghi\u1ec7m l\u00e2m s\u00e0ng v\u1ec1 qu\u00e1 li\u1ec1u ondansetron c\u00f2n r\u1ea5t h\u1ea1n ch\u1ebf. Trong h\u1ea7u h\u1ebft c\u00e1c tr\u01b0\u1eddng h\u1ee3p x\u1ea3y ra, tri\u1ec7u ch\u1ee9ng xu\u1ea5t hi\u1ec7n t\u01b0\u01a1ng t\u1ef1 nh\u01b0 c\u00e1c t\u00e1c \u0111\u1ed9ng b\u1ea5t l\u1ee3i x\u1ea3y ra khi s\u1eed d\u1ee5ng \u1edf li\u1ec1u khuy\u1ebfn c\u00e1o (xem m\u1ee5c T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n). C\u00e1c bi\u1ec3u hi\u1ec7n \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o g\u1ed3m r\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c, t\u00e1o b\u00f3n n\u1eb7ng, t\u1ee5t huy\u1ebft \u00e1p v\u00e0 con v\u1eadn m\u1ea1ch ph\u1ebf v\u1ecb k\u00e8m theo ngh\u1ebdn nh\u0129-th\u1ea5t \u0111\u1ed9 2 tho\u00e1ng qua. Ondansetron k\u00e9o d\u00e0i kho\u1ea3ng QT t\u00f9y thu\u1ed9c li\u1ec1u s\u1eed d\u1ee5ng.<\/p>\n<p><em>\u0110i\u1ec1u tr\u1ecb<\/em><\/p>\n<p>Kh\u00f4ng c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u khi qu\u00e1 li\u1ec1u ondansetron, v\u00ec th\u1ebf khi nghi ng\u1edd qu\u00e1 li\u1ec1u x\u1ea3y ra, c\u1ea7n th\u1ef1c hi\u1ec7n c\u00e1c bi\u1ec7n ph\u00e1p \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng v\u00e0 \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 th\u00edch h\u1ee3p.<\/p>\n<p>Kh\u00f4ng khuy\u1ebfn c\u00e1o g\u00e2y n\u00f4n b\u1eb1ng ipeca do b\u1ec7nh nh\u00e2n kh\u00f4ng th\u1ec3 \u0111\u00e1p \u1ee9ng b\u1edfi t\u00e1c \u0111\u1ed9ng ch\u1ed1ng n\u00f4n c\u1ee7a ch\u00ednh ondansetron.<\/p>\n<p>N\u00ean theo d\u00f5i \u0111i\u1ec7n t\u00e2m \u0111\u1ed3 cho b\u1ec7nh nh\u00e2n khi qu\u00e1 li\u1ec1u<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/strong><\/p>\n<p><strong>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/strong><\/p>\n<p>Nh\u00f3m du\u1ee3c l\u00fd tr\u1ecb li\u1ec7u: thu\u1ed1c ch\u1ed1ng n\u00f4n lo\u1ea1i \u0111\u1ed1i kh\u00e1ng serotonin<\/p>\n<p>M\u00e3 ATC: A04AA01<\/p>\n<p>Ondansetron l\u00e0 thu\u1ed1c \u0111\u1ed1i kh\u00e1ng ch\u1ecdn l\u1ecdc cao tr\u00ean th\u1ee5 th\u1ec3 5-HT3.<\/p>\n<p>C\u01a1 ch\u1ebf ch\u00ednh x\u00e1c c\u1ee7a ondansetron trong ki\u1ec3m so\u00e1t bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n ch\u01b0a \u0111\u01b0\u1ee3c bi\u1ebft r\u00f5. H\u00f3a tr\u1ecb v\u00e0 x\u1ea1 tr\u1ecb c\u00f3 th\u1ec3 d\u1eabn t\u1edbi s\u1ef1 gi\u1ea3i ph\u00f3ng 5HT trong ru\u1ed9t non t\u1eeb \u0111\u00f3 k\u00edch th\u00edch ph\u1ea3n x\u1ea1 n\u00f4n do ho\u1ea1t h\u00f3a d\u00e2y th\u1ea7n kinh ph\u1ebf v\u1ecb th\u00f4ng qua c\u00e1c th\u1ee5 th\u1ec3 5-HT3.<\/p>\n<p>Ondansetron ng\u0103n ch\u1eb7n s\u1ef1 ho\u1ea1t h\u00f3a n\u00e0y. Ho\u1ea1t h\u00f3a th\u1ea7n kinh ph\u1ebf v\u1ecb c\u0169ng g\u00e2y ph\u00f3ng th\u00edch 5HT \u1edf s\u00e0n n\u00e3o th\u1ea5t 4 v\u00e0 ch\u00ednh v\u00ec th\u1ebf c\u00f3 th\u1ec3 k\u00edch th\u00edch trung t\u00e2m n\u00f4n. V\u00ec v\u1eady, t\u00e1c \u0111\u1ed9ng c\u1ee7a ondansetron trong ki\u1ec3m so\u00e1t bu\u1ed3n n\u00f4n, n\u00f4n do h\u00f3a tr\u1ecb, x\u1ea1 tr\u1ecb c\u00f3 th\u1ec3 l\u00e0 do c\u01a1 ch\u1ebf \u0111\u1ed1i kh\u00e1ng v\u1edbi serotonin tr\u00ean th\u1ee5 th\u1ec3 5-HT3 \u1edf c\u1ea3 th\u1ea7n kinh ngo\u1ea1i bi\u00ean v\u00e0 trung \u01b0\u01a1ng. C\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng ch\u1ed1ng bu\u1ed3n n\u00f4n, n\u00f4n sau ph\u1eabu thu\u1eadt c\u0169ng ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh ch\u00ednh x\u00e1c nh\u01b0ng c\u00f3 th\u1ec3 c\u00f3 c\u00f9ng c\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng nh\u01b0 trong tr\u01b0\u1eddng h\u1ee3p tr\u00ean.<\/p>\n<p>Ondansetron kh\u00f4ng l\u00e0m thay \u0111\u1ed5i n\u1ed3ng \u0111\u1ed9 prolactin trong m\u00e1u.<\/p>\n<p>Ch\u01b0a x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c vai tr\u00f2 c\u1ee7a ondansetron trong tr\u01b0\u1eddng h\u1ee3p n\u00f4n do c\u00e1c opiat.<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>Ondansetron l\u00e0 ch\u1ea5t \u0111\u1ed1i kh\u00e1ng ch\u1ecdn l\u1ecdc th\u1ee5 th\u1ec3 5-HT<sub>3<\/sub> (th\u1ee5 th\u1ec3 serotonin nh\u00f3m 3), c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng n\u00f4n. Thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng c\u1ea3 \u1edf ngo\u1ea1i vi, tr\u00ean \u0111\u1ea7u m\u00fat th\u1ea7n kinh ph\u1ebf v\u1ecb v\u00e0 c\u1ea3 \u1edf trung t\u00e2m, trong v\u00f9ng k\u00edch th\u00edch th\u1ee5 th\u1ec3 h\u00f3a h\u1ecdc.<\/p>\n<p><a href=\"https:\/\/www.youtube.com\/watch?v=I1kZxJHepDY\"><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/a><\/p>\n<p><strong>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/strong><\/p>\n<p>\u0110\u1eb7c t\u00ednh d\u01b0\u1ecdc \u0111\u1ed9ng c\u1ee7a ondansetron kh\u00f4ng thay \u0111\u1ed5i khi s\u1eed d\u1ee5ng c\u00e1c li\u1ec1u l\u1eb7p l\u1ea1i. Ch\u01b0a x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c m\u1ed1i t\u01b0\u01a1ng quan tr\u1ef1c ti\u1ebfp gi\u0169a n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong huy\u1ebft t\u01b0\u01a1ng v\u1edbi hi\u1ec7u qu\u1ea3 ch\u1ed1ng n\u00f4n.<\/p>\n<p><em>H\u1ea5p thu<\/em><\/p>\n<p>Khi ti\u00eam t\u0129nh m\u1ea1ch li\u1ec1u 4mg ondansetron trong 5 ph\u00fat, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t \u0111\u01b0\u1ee3c kho\u1ea3ng 65 ng\/ml.<\/p>\n<p><em>Ph\u00e2n b\u1ed5<\/em><\/p>\n<p>S\u1ef1 ph\u00e2n b\u1ed1 c\u1ee7a ondansetron sau khi u\u1ed1ng, ti\u00eam b\u1eafp v\u00e0 ti\u00eam t\u0129nh m\u1ea1ch l\u00e0 t\u01b0\u01a1ng t\u1ef1 nhau v\u1edbi th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh l\u00e0 140 l\u00edt. N\u1ed3ng \u0111\u1ed9 trong m\u00e1u c\u0169ng \u0111\u1ea1t \u1edf m\u1ee9c t\u01b0\u01a1ng t\u1ef1 nhau sau khi ti\u00eam b\u1eafp ho\u1eb7c ti\u00eam t\u0129nh m\u1ea1ch. Ondansetron kh\u00f4ng li\u00ean k\u1ebft m\u1ea1nh v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng (70-76%).<\/p>\n<p><em>Chuy\u1ec3n h\u00f3a<\/em><\/p>\n<p>Ondansetron \u0111\u01b0\u1ee3c thanh th\u1ea3i kh\u1ecfi h\u1ec7 th\u1ed1ng tu\u1ea7n ho\u00e0n ch\u1ee7 y\u1ebfu b\u1edfi chuy\u1ec3n h\u00f3a \u1edf gan qua nhi\u1ec1u enzym chuy\u1ec3n h\u00f3a kh\u00e1c nhau. S\u1ef1 thi\u1ebfu h\u1ee5t enzym CYP2D6 (\u0111a h\u00ecnh debrisoquin) kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a ondansetron.<\/p>\n<p><em>Th\u1ea3i tr\u1eeb<\/em><\/p>\n<p>C\u00f3 d\u01b0\u1edbi 5% li\u1ec1u ondansetron h\u1ea5p thu \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb nguy\u00ean v\u1eb9n trong n\u01b0\u1edbc ti\u1ec3u. Th\u1eddi gian b\u00e1n th\u1ea3i sau c\u00f9ng l\u00e0 kho\u1ea3ng 3 gi\u1edd.<\/p>\n<p>D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc tr\u00ean nh\u00f3m b\u1ec7nh nh\u00e2n \u0111\u1eb7c bi\u1ec7t<\/p>\n<p><em>Tr\u1ebb em v\u00e0 thi\u1ebfu ni\u00ean (1 th\u00e1ng \u0111\u1ebfn 17 tu\u1ed5i)<\/em><\/p>\n<p>\u1ede tr\u1ebb em t\u1eeb 1-4 th\u00e1ng tu\u1ed5i (n = 19) dupe ph\u1eabu thu\u1eadt, s\u1ef1 thanh th\u1ea3i thu\u1ed1c hi\u1ec7u ch\u1ec9nh theo th\u1ec3 tr\u1ecdng ch\u1eadm h\u01a1n kho\u1ea3ng 30% so v\u1edbi b\u1ec7nh nhi t\u1eeb 5-24 th\u00e1ng tu\u1ed5i (n = 22) nh\u01b0ng l\u1ea1i t\u01b0\u01a1ng t\u1ef1 v\u1edbi nh\u00f3m b\u1ec7nh nhi t\u1eeb 3-12 tu\u1ed5i. Th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh \u1edf nh\u00f3m tr\u1ebb em t\u1eeb 1-4 th\u00e1ng tu\u1ed5i l\u00e0 kho\u1ea3ng 6,7 gi\u1edd, \u1edf nh\u00f3m b\u1ec7nh nhi t\u1eeb 5-24 th\u00e1ng tu\u1ed5i v\u00e0 3-13 tu\u1ed5i l\u00e0 2,9 gi\u1edd. S\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 c\u00e1c th\u00f4ng s\u1ed1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc \u1edf nh\u00f3m b\u1ec7nh nhi t\u1eeb 1-4 th\u00e1ng tu\u1ed5i c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c gi\u1ea3i th\u00edch m\u1ed9t ph\u1ea7n l\u00e0 do t\u1ed5ng l\u01b0\u1ee3ng n\u01b0\u1edbc trong c\u01a1 th\u1ec3 tr\u1ebb s\u01a1 sinh cao hon v\u00e0 do ondansetron l\u00e0 thu\u1ed1c tan t\u1ed1t trong pha n\u01b0\u1edbc.<\/p>\n<p>\u1ede c\u00e1c b\u1ec7nh nhi t\u1eeb 3-12 tu\u1ed5i \u0111\u01b0\u1ee3c ph\u1eabu thu\u1eadt l\u1ef1a ch\u1ecdn qua g\u00e2y m\u00ea t\u1ed5ng qu\u00e1t, tr\u1ecb s\u1ed1 tuy\u1ec7t \u0111\u1ed1i c\u1ee7a s\u1ef1 thanh th\u1ea3i v\u00e0 ph\u00e2n b\u1ed1 c\u1ee7a ondansetron gi\u1ea3m so v\u1edbi b\u1ec7nh nh\u00e2n ng\u01b0\u1eddi l\u1edbn. C\u1ea3 2 th\u00f4ng s\u1ed1 n\u00e0y t\u0103ng tuy\u1ebfn t\u00ednh theo \u0111\u1ed9 tu\u1ed5i v\u00e0 cho \u0111\u1ebfn 12 tu\u1ed5i th\u00ec c\u00e1c tr\u1ecb s\u1ed1 n\u00e0y t\u01b0\u01a1ng t\u1ef1 v\u1edbi tr\u1ecb s\u1ed1 \u1edf b\u1ec7nh nh\u00e2n ng\u01b0\u1eddi l\u1edbn tr\u1ebb tu\u1ed5i. Khi t\u00ednh to\u00e1n \u0111\u1ed9 thanh th\u1ea3i v\u00e0 th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 theo th\u1ec3 tr\u1ecdng, tr\u1ecb s\u1ed1 c\u00e1c th\u00f4ng s\u1ed1 n\u00e0y l\u00e0 t\u01b0\u01a1ng t\u1ef1 nhau gi\u1eefa c\u00e1c nh\u00f3m d\u00e2n s\u1ed1 c\u00f3 \u0111\u1ed9 tu\u1ed5i kh\u00e1c nhau. Vi\u1ec7c t\u00ednh li\u1ec1u theo th\u1ec3 tr\u1ecdng s\u1ebd gi\u00fap b\u00f9 tr\u1eeb c\u00e1c kh\u00e1c bi\u1ec7t v\u1ec1 \u0111\u1ed9 tu\u1ed5i v\u00e0 h\u1eefu hi\u1ec7u trong vi\u1ec7c b\u00ecnh th\u01b0\u1eddng h\u00f3a t\u1ed5ng l\u01b0\u1ee3ng thu\u1ed1c trong tu\u1ea7n ho\u00e0n \u1edf nh\u00f3m b\u1ec7nh nhi.<\/p>\n<p>Ph\u00e2n t\u00edch d\u01b0\u1ee3c \u0111\u1ed9ng \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n tr\u00ean 428 b\u1ec7nh nh\u00e2n (b\u1ec7nh nh\u00e2n ung th\u01b0, b\u1ec7nh nh\u00e2n ph\u1eabu thu\u1eadt v\u00e0 ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n kh\u1ecfe m\u1ea1nh) c\u00f3 \u0111\u1ed9 tu\u1ed5i t\u1eeb 1 th\u00e1ng \u0111\u1ebfn 44 tu\u1ed5i sau khi ti\u00eam t\u0129nh m\u1ea1ch ondansetron. C\u0103n c\u1ee9 tr\u00ean ph\u00e2n t\u00edch n\u00e0y, t\u1ed5ng l\u01b0\u1ee3ng ondansetron trong m\u00e1u (AUC) sau khi u\u1ed1ng ho\u1eb7c ti\u00eam t\u0129nh m\u1ea1ch \u1edf tr\u1ebb em v\u00e0 thi\u1ebfu ni\u00ean l\u00e0 t\u01b0\u01a1ng t\u1ef1 v\u1edbi ng\u01b0\u00f2i l\u1edbn, ngo\u1ea1i tr\u1eeb nh\u00f3m tr\u1ebb s\u01a1 sinh t\u1eeb 1-4 th\u00e1ng tu\u1ed5i. Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 l\u1ec7 thu\u1ed9c v\u00e0o \u0111\u1ed9 tu\u1ed5i v\u00e0 ng\u01b0\u1eddi l\u1edbn c\u00f3 th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 th\u1ea5p h\u01a1n so v\u1edbi tr\u1ebb s\u01a1 sinh v\u00e0 tr\u1ebb em. \u0110\u1ed9 thanh th\u1ea3i l\u1ec7 thu\u1ed9c v\u00e0o th\u1ec3 tr\u1ecdng ch\u1ee9 kh\u00f4ng l\u1ec7 thu\u1ed9c v\u00e0o \u0111\u1ed9 tu\u1ed5i, ngo\u1ea1i tr\u1eeb nh\u00f3m tr\u1ebb s\u01a1 sinh t\u1eeb 1-4 th\u00e1ng tu\u1ed5i. R\u1ea5t kh\u00f3 k\u1ebft lu\u1eadn r\u1eb1ng s\u1ef1 thanh th\u1ea3i thu\u1ed1c gi\u1ea3m th\u00eam theo \u0111\u1ed9 tu\u1ed5i \u1edf nh\u00f3m tr\u1ebb s\u01a1 sinh t\u1eeb 1-4 th\u00e1ng tu\u1ed5i ho\u1eb7c \u0111\u01a1n gi\u1ea3n l\u00e0 do s\u1ef1 bi\u1ebfn thi\u00ean v\u00ec s\u1ed1 l\u01b0\u1ee3ng \u0111\u1ed1i t\u01b0\u1ee3ng nghi\u00ean c\u1ee9u th\u1ea5p. Do c\u00e1c b\u1ec7nh nh\u00e2n d\u01b0\u1edbi 6 th\u00e1ng tu\u1ed5i ch\u1ec9 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh 1 li\u1ec1u duy nh\u1ea5t ondansetron trong d\u1ef1 ph\u00f2ng bu\u1ed3n n\u00f4n, n\u00f4n sau ph\u1eabu thu\u1eadt, v\u00ec th\u1ebf, \u0111\u1ed9 thanh th\u1ea3i thu\u1ed1c gi\u1ea3m c\u00f3 th\u1ec3 kh\u00f4ng mang \u00fd ngh\u0129a l\u00e2m s\u00e0ng.<\/p>\n<p><em>B\u1ec7nh nh\u00e2n cao tu\u1ed5i<\/em><\/p>\n<p>Nghi\u00ean c\u1ee9u tr\u00ean c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng t\u00ecnh nguy\u1ec7n kh\u1ecfe m\u1ea1nh, cao tu\u1ed5i cho th\u1ea5y th\u1eddi gian b\u00e1n th\u1ea3i t\u0103ng nh\u1eb9 (5 gi\u1edd).<\/p>\n<p><em>B\u1ec7nh nh\u00e2n suy th\u1eadn<\/em><\/p>\n<p>\u1edf c\u00e1c b\u1ec7nh nh\u00e2n suy th\u1eadn (\u0111\u1ed9 thanh th\u1ea3i creatinin 15-60 ml\/ph\u00fat), \u0111\u1ed9 thanh th\u1ea3i v\u00e0 th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 gi\u1ea3m sau khi ti\u00eam t\u0129nh m\u1ea1ch ondansetron nh\u01b0ng kh\u00f4ng mang \u00fd ngh\u0129a l\u00e2m s\u00e0ng v\u00e0 th\u1eddi gian b\u00e1n th\u1ea3i t\u0103ng (5,4 gi\u1edd). M\u1ed9t nghi\u00ean c\u1ee9u tr\u00ean b\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng, th\u01b0\u1eddng xuy\u00ean ph\u1ea3i th\u1ea9m ph\u00e2n m\u00e1u cho th\u1ea5y d\u01b0\u1ecd&#8217;c \u0111\u1ed9ng h\u1ecdc c\u1ee7a ondansetron kh\u00f4ng thay \u0111\u1ed5i sau khi s\u1eed d\u1ee5ng \u0111\u01b0\u1eddng ti\u00eam t\u0129nh m\u1ea1ch.<\/p>\n<p><em>B\u1ec7nh nh\u00e2n suy gan<\/em><\/p>\n<p>\u1edf c\u00e1c b\u1ec7nh nh\u00e2n suy gan n\u1eb7ng, \u0111\u1ed9 thanh th\u1ea3i ondansetron gi\u1ea3m r\u00f5 r\u1ec7t v\u00e0 th\u1eddi gian b\u00e1n th\u1ea3i k\u00e9o d\u00e0i (15-32 gi\u1edd).<\/p>\n<p><em>S\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 gi\u1edbi t\u00ednh<\/em><\/p>\n<p>Nghi\u00ean c\u1ee9u kh\u00e1c bi\u1ec7t v\u1ec1 gi\u1edbi t\u00ednh cho th\u1ea5y n\u1eef gi\u1edbi c\u00f3 t\u1ed1c \u0111\u1ed9 v\u00e0 m\u1ee9c \u0111\u1ed9 h\u1ea5p thu cao h\u01a1n sau khi u\u1ed1ng ondansetron, \u0111\u1ed9 thanh th\u1ea3i v\u00e0 th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 gi\u1ea3m (hi\u1ec7u ch\u1ec9nh theo th\u1ec3 tr\u1ecdng) so v\u1edbi nam gi\u1edbi.<\/p>\n<p><strong>5.3 Gi\u1ea3i th\u00edch: <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong>5.4 Thay th\u1ebf thu\u1ed1c : <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/strong><\/p>\n<p><strong>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/strong><\/p>\n<p><strong>6.2. T\u01b0\u01a1ng k\u1ef5 :<\/strong><\/p>\n<p>Kh\u00f4ng n\u00ean pha ondansetron v\u1edbi c\u00e1c dung d\u1ecbch kh\u00e1c tr\u1eeb nh\u1eefng dung d\u1ecbch trong m\u1ee5c Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch d\u00f9ng<\/p>\n<p><strong>6.3. B\u1ea3o qu\u1ea3n: <\/strong><\/p>\n<p>B\u1ea3o qu\u1ea3n \u1edf nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30\u00b0c. Tr\u00e1nh \u00e1nh s\u00e1ng.<\/p>\n<p>\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u1ec1 m\u1eb7t h\u00f3a l\u00fd c\u1ee7a thu\u1ed1c sau khi pha v\u1edbi c\u00e1c dung d\u1ecbch t\u01b0\u01a1ng th\u00edch l\u00e0 48 gi\u1edd \u1edf 25\u00b0c. v\u1ec1 m\u1eb7t vi sinh, n\u00ean s\u1eed d\u1ee5ng thu\u1ed1c ngay sau khi pha. Trong tr\u01b0\u1eddng h\u1ee3p kh\u00f4ng s\u1eed d\u1ee5ng h\u1ebft trong l\u1ea7n \u0111\u1ea7u ti\u00ean, b\u1ea3o qu\u1ea3n thu\u1ed1c trong t\u1ee7 l\u1ea1nh \u1edf nhi\u1ec7t \u0111\u1ed9 2-8\u00b0C nh\u01b0ng kh\u00f4ng n\u00ean v\u01b0\u1ee3t qu\u00e1 24 gi\u1edd, tr\u1eeb khi thu\u1ed1c \u0111\u01b0\u1ee3c b\u1ea3o qu\u1ea3n \u1edf \u0111i\u1ec1u ki\u1ec7n v\u00f4 khu\u1ea9n \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t ch\u1eb7t ch\u1ebd.<\/p>\n<p><strong>6.4. Th\u00f4ng tin kh\u00e1c :<\/strong><\/p>\n<p>Kh\u00f4ng c\u00f3.<\/p>\n<p><strong>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/strong><\/p>\n<p>D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n<p>Ho\u1eb7c HDSD Thu\u1ed1c.<\/p>\n<p><strong>7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<\/strong><\/p>\n<p>B\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c s\u01b0u t\u1ea7m ho\u1eb7c vi\u1ebft b\u1edfi: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-tac-gia-bac-sy-do-my-linh\/\">B\u00e1c s\u0129 nhi khoa &#8211; \u0110\u1ed7 M\u1ef9 Linh.<\/a><\/p>\n<p>Ki\u1ec3m duy\u1ec7t , hi\u1ec7u \u0111\u00ednh v\u00e0 \u0111\u0103ng t\u1ea3i: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-ve-pharmog-team\/\">PHARMOG TEAM<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Ondansetron Kabi l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Ondansetron Kabi (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;) 1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Ondansetron Ph\u00e2n lo\u1ea1i: Thu\u1ed1c ch\u1ed1ng n\u00f4n, [&hellip;]<\/p>\n","protected":false},"author":8612,"featured_media":28377,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[1103],"class_list":["post-28376","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-ondansetron"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/28376","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/8612"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=28376"}],"version-history":[{"count":4,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/28376\/revisions"}],"predecessor-version":[{"id":46648,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/28376\/revisions\/46648"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/28377"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=28376"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=28376"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=28376"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}