{"id":28351,"date":"2021-01-31T08:52:25","date_gmt":"2021-01-31T01:52:25","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=28351"},"modified":"2025-01-08T11:52:30","modified_gmt":"2025-01-08T04:52:30","slug":"ondansetron-atozone-s-samtron","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/ondansetron-atozone-s-samtron\/","title":{"rendered":"Ondansetron &#8211; Atozone-S\/Samtron"},"content":{"rendered":"<p><em>Thu\u1ed1c Atozone-S,<\/em> Samtron<em> l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Atozone-S, Samtron (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;)<\/em><\/p>\n<p><strong>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: <\/strong><\/p>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <\/strong><a href=\"https:\/\/pharmog.com\/wp\/ondansetron\/\"><strong>Ondansetron<\/strong><\/a><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u1ed1c ch\u1ed1ng n\u00f4n, \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 5-HT3.<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): A04AA01.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em><\/strong><\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c:<\/em><\/strong> Atozone-S, Samtron<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: M\/S Samrudh Pharmaceuticals Pvt., Ltd.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng: <\/strong><\/p>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>Dung d\u1ecbch ti\u00eam: 2 mg\/ml.<\/p>\n<p>H\u1ed9p 5 \u1ed1ng x 4ml<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>ATOZONE-S<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i 4ml dung d\u1ecbch ti\u00eam c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Ondansetron<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>8 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"425\" height=\"376\" class=\"wp-image-28352\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/01\/word-image-423.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/01\/word-image-423.png 425w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2021\/01\/word-image-423-300x265.png 300w\" sizes=\"auto, (max-width: 425px) 100vw, 425px\" \/><\/p>\n<p><strong>3. Video by Pharmog:<\/strong><\/p>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe loading=\"lazy\" title=\"[Pharmog SS1 - T\u1eadp 02] - D\u01b0\u1ee3c l\u00fd c\u00e1c thu\u1ed1c ch\u1ed1ng n\u00f4n\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/I1kZxJHepDY?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<p><strong>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng: <\/strong><\/p>\n<p><strong>4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>Ph\u00f2ng bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n li\u00ean quan v\u1edbi c\u00e1c \u0111\u1ee3t \u0111i\u1ec1u tr\u1ecb kh\u1edfi \u0111\u1ea7u v\u00e0 l\u1eb7p l\u1ea1i c\u1ee7a ho\u00e1 tr\u1ecb ung th\u01b0 c\u00f3 g\u00e2y \u00f3i m\u1eeda, bao g\u1ed3m c\u1ea3 li\u1ec7u ph\u00e1p cisplatin li\u1ec1u cao.<\/p>\n<p>Ph\u00f2ng ch\u1ed1ng bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n sau ph\u1eabu thu\u1eadt. Gi\u1ed1ng nh\u01b0 c\u00e1c thu\u1ed1c ch\u1ed1ng n\u00f4n kh\u00e1c, d\u1ef1 ph\u00f2ng th\u01b0\u1eddng kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o cho b\u1ec7nh nh\u00e2n c\u00f3 \u00edt kh\u1ea3 n\u0103ng bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n s\u1ebd x\u1ea3y ra sau ph\u1eabu thu\u1eadt. \u1ede nh\u1eefng b\u1ec7nh nh\u00e2n c\u1ea7n ph\u1ea3i tr\u00e1nh bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n sau ph\u1eabu thu\u1eadt, khuy\u1ebfn c\u00e1o ti\u00eam ondansetron, ngay c\u1ea3 khi t\u1ef7 l\u1ec7 c\u1ee7a bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n sau ph\u1eabu thu\u1eadt l\u00e0 th\u1ea5p. \u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n kh\u00f4ng \u0111\u01b0\u1ee3c ti\u00eam ondansetron \u0111\u1ec3 d\u1ef1 ph\u00f2ng v\u00e0 c\u00f3 bu\u1ed3n n\u00f4n v\u00e0\/ ho\u1eb7c n\u00f4n sau ph\u1eabu thu\u1eadt, c\u00f3 th\u1ec3 ti\u00eam ondansetron \u0111\u1ec3 ng\u0103n ch\u1eb7n c\u01a1n bu\u1ed3n n\u00f4n\/ n\u00f4n ti\u1ebfp theo.<\/p>\n<p><strong>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/strong><\/p>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p>Thu\u1ed1c ti\u00eam Ondansetron pha lo\u00e3ng t\u1eeb tr\u01b0\u1edbc trong c\u00e1c d\u1ee5ng c\u1ee5 \u0111\u1ef1ng d\u1ecbch truy\u1ec1n b\u1eb1ng nh\u1ef1a d\u1ebbo:<\/p>\n<p><em>H\u01b0\u1edbng d\u1eabn s\u1eed dung:<\/em><\/p>\n<p>\u0110\u1ec3 m\u1edf: x\u00e9 b\u1ecdc ngo\u00e0i ch\u1ed7 kh\u00eda V v\u00e0 l\u1ea5y b\u1ed9 ph\u1eadn ch\u1ee9a dung d\u1ecbch ra. Ki\u1ec3m tra r\u00f2 r\u1ec9 ph\u00fat b\u1eb1ng c\u00e1ch \u00e9p ch\u1eafc. N\u1ebfu c\u00f3 r\u00f2 r\u1ec9 th\u00ec kh\u00f4ng d\u00f9ng thu\u1ed1c n\u1eefa v\u00ec s\u1ef1 v\u00f4 khu\u1ea9n c\u00f3 th\u1ec3 b\u1ecb \u1ea3nh h\u01b0\u1edfng.<\/p>\n<p>Chu\u1ea9n b\u1ecb cho vi\u1ec7c ti\u00eam thu\u1ed1c: S\u1eed d\u1ee5ng k\u1ef9 thu\u1eadt v\u00f4 tr\u00f9ng.<\/p>\n<p>\u0110\u00f3ng n\u1eb9p ki\u1ec3m so\u00e1t d\u00f2ng c\u1ee7a b\u1ed9 ph\u1eadn d\u1eabn thu\u1ed1c.<\/p>\n<p>B\u1ecf b\u1ecdc ngo\u00e0i g\u1ed3m t\u1eeb ch\u1ed7 m\u1edf ph\u00eda d\u01b0\u1edbi chai thu\u1ed1c.<\/p>\n<p>Ch\u00e8n m\u1ed9t ph\u1ea7n ch\u1ed1t c\u1ee7a b\u1ed9 ph\u1eadn d\u1eabn thu\u1ed1c v\u00e0o n\u01a1i ti\u1ebfp nh\u1eadn v\u1edbi m\u1ed9t chuy\u1ec3n \u0111\u1ed9ng xo\u1eafn cho \u0111\u1ebfn khi ch\u1ed1t c\u1eafm v\u00e0o m\u1ed9t c\u00e1ch v\u1eefng ch\u1eafc.<\/p>\n<p>Ch\u00fa \u00fd: Xem h\u01b0\u1edbng d\u1eabn \u0111\u1ea7y \u0111\u1ee7 v\u1ec1 b\u1ed9 ph\u1eadn d\u1eabn thu\u1ed1c tr\u00ean gi\u1ea5y carton \u0111\u00ednh k\u00e8m.<\/p>\n<p>\u0110\u1ec3 chai thu\u1ed1c tr\u00ean m\u00f3c treo.<\/p>\n<p>B\u00f3p v\u00e0 l\u00e0m tho\u00e1t bu\u1ed3ng nh\u1ecf gi\u1ecdt \u0111\u1ec3 thi\u1ebft l\u1eadp m\u1ee9c ch\u1ea5t l\u1ecfng th\u00edch h\u1ee3p trong bu\u1ed3ng trong su\u1ed1t th\u1eddi gian truy\u1ec1n d\u1ecbch Ondansetron pha lo\u00e3ng t\u1eeb tr\u01b0\u1edbc (ONDANSETRON Injection Premixed)<\/p>\n<p>M\u1edf n\u1eb9p \u0111i\u1ec1u khi\u1ec3n d\u00f2ng tho\u00e1t h\u1ebft kh\u00f4ng kh\u00ed t\u1eeb c\u00e1c b\u1ed9 ph\u1eadn ti\u00eam thu\u1ed1c. \u0110\u00f3ng n\u1eb9p.<\/p>\n<p>\u0110\u00ednh b\u1ed9 ph\u1eadn ti\u00eam thu\u1ed1c v\u00e0o thi\u1ebft b\u1ecb ti\u00eam t\u0129nh m\u1ea1ch. N\u1ebfu thi\u1ebft b\u1ecb kh\u00f4ng kh\u1edbp v\u00e0o trong, \u0111i\u1ec1u ch\u1ec9nh cho kh\u1edbp.<\/p>\n<p>Th\u1ef1c hi\u1ec7n vi\u1ec7c ti\u00eam.<\/p>\n<p>\u0110i\u1ec1u ch\u1ec9nh t\u1ed1c \u0111\u1ed9 c\u1ee7a b\u1ed9 ph\u1eadn d\u1eabn thu\u1ed1c v\u1edbi k\u1eb9p ki\u1ec3m so\u00e1t d\u00f2ng ch\u1ea3y.<\/p>\n<p><em>L\u01b0u \u00fd<\/em><\/p>\n<p>L\u01b0u \u00fd: Thu\u1ed1c ti\u00eam Ondansetron pha lo\u00e3ng t\u1eeb tr\u01b0\u1edbc (ONDANSETRON Injection Premixed) trong c\u00e1c d\u1ee5ng c\u1ee5 ch\u1ee9a b\u1eb1ng nh\u1ef1a d\u1ebbo ch\u1ec9 \u0111\u01b0\u1ee3c d\u00f9ng cho truy\u1ec1n t\u0129nh m\u1ea1ch nh\u1ecf gi\u1ecdt. Ondansetron ti\u00eam tr\u1ed9n kh\u00f4ng n\u00ean \u0111\u01b0\u1ee3c tr\u1ed9n l\u1eabn v\u1edbi c\u00e1c dung m\u00f4i m\u00e0 cho kh\u1ea3 n\u0103ng t\u01b0\u01a1ng th\u00edch v\u1eadt l\u00fd v\u00e0 ho\u00e1 h\u1ecdc ch\u01b0a \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp. \u0110\u1eb7c bi\u1ec7t, \u0111i\u1ec1u n\u00e0y \u00e1p d\u1ee5ng v\u1edbi c\u00e1c dung m\u00f4i c\u00f3 t\u00ednh ki\u1ec1m v\u00ec k\u1ebft t\u1ee7a c\u00f3 th\u1ec3 x\u1ea3y ra. N\u1ebfu ban \u0111\u1ea7u \u0111\u00e3 s\u1eed d\u1ee5ng h\u1ec7 th\u1ed1ng truy\u1ec1n d\u1ecbch n\u00e0o \u0111\u00f3, c\u1ea7n ng\u01b0ng vi\u1ec7c truy\u1ec1n d\u1ecbch n\u00e0y trong khi s\u1eed d\u1ee5ng Ondansetron Injection Premixed. Kh\u00f4ng \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh b\u01a1m ti\u00eam thu\u1ed1c n\u1ebfu dung d\u1ecbch kh\u00f4ng trong v\u00e0 d\u1ee5ng c\u1ee5 \u0111\u1ef1ng thu\u1ed1c b\u1ecb h\u01b0 h\u1ea1i.<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p>D\u00f9ng ch\u1ed1ng n\u00f4n v\u00e0 bu\u1ed3n n\u00f4n do ho\u00e1 tr\u1ecb li\u1ec7u<\/p>\n<p><em>Li\u1ec1u d\u00f9ng cho ng\u01b0\u1eddi l\u1edbn<\/em><\/p>\n<p>Li\u1ec1u d\u00f9ng khuy\u1ebfn c\u00e1o c\u1ee7a Ondansetron \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch l\u00e0 li\u1ec1u \u0111\u01a1n 32mg ho\u1eb7c 3 li\u1ec1u 0.15mg\/kg. Khi d\u00f9ng li\u1ec1u \u0111\u01a1n 32mg, truy\u1ec1n t\u0129nh m\u1ea1ch k\u00e9o dai2 15 ph\u00fat v\u00e0 tr\u01b0\u1edbc khi ti\u1ebfn h\u00e0nh ho\u00e1 tr\u1ecb 30 ph\u00fat. Kh\u00f4ng n\u00ean truy\u1ec1n nhanh h\u01a1n t\u1ed1c \u0111\u1ed9 khuy\u1ebfn c\u00e1o.<\/p>\n<p>V\u1edbi ph\u00e1c \u0111\u1ed3 d\u00f9ng 3 li\u1ec1u, li\u1ec1u \u0111\u1ea7u ti\u00ean, truy\u1ec1n trong th\u1eddi gian 15 ph\u00fat tr\u01b0\u1edbc khi ho\u00e1 tr\u1ecb 30 ph\u00fat. C\u00e1c li\u1ec1u ti\u1ebfp theo (0.15mg\/kg), d\u00f9ng c\u00e1ch li\u1ec1u \u0111\u1ea7u ti\u00ean l\u1ea7n l\u01b0\u1ee3t l\u00e0 4 v\u00e0 8 gi\u1edd.<\/p>\n<p>Kh\u00f4ng n\u00ean tr\u1ed9n ondansetron v\u1edbi c\u00e1c dung d\u1ecbch thu\u1ed1c kh\u00e1c do c\u00e1c k\u1ebft qu\u1ea3 t\u01b0\u01a1ng k\u1ef5 ho\u00e1 h\u1ecdc v\u00e0 v\u1eadt l\u00fd ch\u01b0a \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp, nh\u1ea5t l\u00e0 c\u00e1c dung d\u1ecbch ki\u1ec1m v\u00ec c\u00f3 th\u1ec3 g\u00e2y t\u1ee7a ondansetron.<\/p>\n<p>Thu\u1ed1c trong l\u1ecd: pha lo\u00e3ng TR\u01af\u1edaC KHI S\u1eec D\u1ee4NG \u0111\u1ec3 PH\u00d2NG NG\u1eeaA c\u1ea3m \u1ee9ng g\u00e2y bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n do HO\u00c1 H\u1eccC TR\u1eca LI\u1ec6U. Thu\u1ed1c ti\u00eam ondansetron n\u00ean \u0111\u01b0\u1ee3c pha lo\u00e3ng trong 50 ml dung d\u1ecbch thu\u1ed1c ti\u00eam Dextrose 5% ho\u1eb7c NaCl 0.9% ti\u00eam tr\u01b0\u1edbc khi d\u00f9ng.<\/p>\n<p>Y\u00caU C\u1ea6U kh\u00f4ng pha lo\u00e3ng tr\u1ef1c ti\u1ebfp trong c\u00e1c d\u1ee5ng c\u1ee5 \u0111\u1ef1ng d\u1ecbch truy\u1ec1n b\u1eb1ng nh\u1ef1a d\u1ebbo. Thu\u1ed1c ti\u00eam Ondansetron c\u1ea7n pha lo\u00e3ng t\u1eeb n\u01b0\u1edbc (ONDANSETRON Injection Premixed), 32 mg trong Dextrose 5%, 50ml.<\/p>\n<p><em>Li\u1ec1u d\u00f9ng cho tr\u1ebb em<\/em><\/p>\n<p>V\u1edbi nh\u1eefng th\u00f4ng tin hi\u1ec7n c\u00f3, li\u1ec1u d\u00f9ng cho tr\u1ebb em t\u1eeb 6 th\u00e1ng t\u1edbi 18 tu\u1ed5i l\u00e0 3 li\u1ec1u 0.15mg\/kg. Li\u1ec1u \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c ti\u00eam truy\u1ec1n 30 ph\u00fat tr\u01b0\u1edbc khi d\u00f9ng c\u00e1c thu\u1ed1c c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y n\u00f4n \u1edf m\u1ee9c trung b\u00ecnh v\u00e0 cao, ti\u1ebfp theo, 2 li\u1ec1u c\u00f2n l\u1ea1i \u0111\u01b0\u1ee3c d\u00f9ng sau \u0111\u00f3 4 v\u00e0 8 gi\u1edd. N\u00ean truy\u1ec1n thu\u1ed1c trong th\u1eddi gian 15 ph\u00fat. Hi\u1ec7n c\u00f3 \u00edt th\u00f4ng tin v\u1ec1 li\u1ec1u d\u00f9ng c\u1ee7a thu\u1ed1c cho tr\u1ebb em d\u01b0\u1edbi 6 th\u00e1ng b\u1ecb ung th\u01b0.<\/p>\n<p>Thu\u1ed1c trong l\u1ecd: Pha lo\u00e3ng tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng. Thu\u1ed1c ti\u00eam Ondansetron n\u00ean \u0111\u01b0\u1ee3c pha lo\u00e3ng trong 50ml dung d\u1ecbch thu\u1ed1c ti\u00eam Dextrose 5% ho\u1eb7c NaCl 0.9% ti\u00eam tr\u01b0\u1edbc khi d\u00f9ng.<\/p>\n<p>Y\u00caU C\u1ea6U kh\u00f4ng pha lo\u00e3ng tr\u1ef1c ti\u1ebfp trong c\u00e1c d\u1ee5ng c\u1ee5 \u0111\u1ef1ng d\u1ecbch truy\u1ec1n b\u1eb1ng nh\u1ef1a d\u1ebbo. Thu\u1ed1c ti\u00eam Ondansetron c\u1ea7n pha lo\u00e3ng t\u1eeb n\u01b0\u1edbc (ONDANSETRON Injection Premixed), 32 mg trong Dextrose 5%, 50ml.<\/p>\n<p><em>Li\u1ec1u d\u00f9ng cho ng\u01b0\u1eddi gi\u00e0<\/em><\/p>\n<p>Li\u1ec1u khuy\u1ebfn c\u00e1o t\u01b0\u01a1ng t\u1ef1 nh\u01b0 c\u1ee7a ng\u01b0\u1eddi tr\u1ebb tu\u1ed5i.<\/p>\n<p>D\u1ef1 ph\u00f2ng n\u00f4n v\u00e0 bu\u1ed3n n\u00f4n sau ph\u1eabu thu\u1eadt:<\/p>\n<p><em>Li\u1ec1u d\u00f9ng cho ng\u01b0\u1eddi l\u1edbn:<\/em><\/p>\n<p>Li\u1ec1u khuy\u1ebfn c\u00e1o \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch c\u1ee7a Ondansetron cho ng\u01b0\u1eddi l\u1edbn l\u00e0 4mg, kh\u00f4ng pha lo\u00e3ng, ti\u00eam t\u0129nh m\u1ea1ch trong th\u1eddi gian kh\u00f4ng d\u01b0\u1edbi 30 gi\u00e2y, t\u1ed1t nh\u1ea5t l\u00e0 trong 2 t\u1edbi 5 ph\u00fat ngay tr\u01b0\u1edbc khi ti\u1ebfn h\u00e0nh g\u00e2y m\u00ea ho\u1eb7c ngay sau khi ph\u1eabu thu\u1eadt n\u1ebfu b\u1ec7nh nh\u00e2n b\u1ecb n\u00f4n v\u00e0\/ho\u1eb7c bu\u1ed3n n\u00f4n ngay sau khi ph\u1eabu thu\u1eadt. Ngo\u00e0i ra, c\u00f3 th\u1ec3 d\u00f9ng li\u1ec1u 4mg kh\u00f4ng pha lo\u00e3ng ti\u00eam b\u1eafp cho ng\u01b0\u1eddi l\u1edbn. V\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n kh\u00f4ng \u0111\u00e1p \u1ee9ng t\u1ed1t v\u1edbi ph\u00e1c \u0111\u1ed3 d\u1ef1 ph\u00f2ng sau khi d\u00f9ng \u0111\u01a1n li\u1ec1u ti\u00eam t\u0129nh m\u1ea1ch 4mg ondansetron, vi\u1ec7c d\u00f9ng li\u1ec1u ti\u1ebfp theo sau khi ph\u1eabu thu\u1eadt kh\u00f4ng gi\u00fap t\u0103ng hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>Kh\u00f4ng pha lo\u00e3ng thu\u1ed1c khi d\u00f9ng \u0111\u1ec3 d\u1ef1 ph\u00f2ng bu\u1ed3n n\u00f4n\/n\u00f4n h\u1eadu ph\u1eabu<\/p>\n<p><em>Li\u1ec1u d\u00f9ng cho tr\u1ebb em<\/em><\/p>\n<p>Li\u1ec1u khuy\u1ebfn c\u00e1o c\u1ee7a Ondansetron cho tr\u1ebb em \u0111\u1ec3 d\u1ef1 ph\u00f2ng n\u00f4n v\u00e0\/ ho\u1eb7c bu\u1ed3n n\u00f4n sau ph\u1eabu thu\u1eadt \u1edf tr\u1ebb em (t\u1eeb 1 th\u00e1ng tu\u1ed5i t\u1edbi 12 tu\u1ed5i) l\u00e0 li\u1ec1u \u0111\u01a1n 0.1mg\/kg cho tr\u01b0\u1eddng h\u1ee3p b\u1ec7nh nh\u00e2n d\u01b0\u1edbi 40kg ho\u1eb7c li\u1ec1u \u0111\u01a1n 4mg cho nh\u1eefng b\u1ec7nh nh\u00e2n tr\u00ean 40kg. Th\u1eddi gian ti\u00eam t\u0129nh m\u1ea1ch kh\u00f4ng n\u00ean \u00edt h\u01a1n 30 gi\u00e2y, t\u1ed1t nh\u1ea5t l\u00e0 t\u1eeb 2 t\u1edbi 5 ph\u00fat ngay tr\u01b0\u1edbc khi ho\u1eb7c sau g\u00e2y m\u00ea ho\u1eb7c sau ph\u1eabu thu\u1eadt n\u1ebfu b\u1ec7nh nh\u00e2n b\u1ecb n\u00f4n ho\u1eb7c bu\u1ed3n n\u00f4n ngay sau khi ph\u1eabu thu\u1eadt. Vi\u1ec7c d\u1ef1 ph\u00f2ng n\u00f4n v\u00e0 bu\u1ed3n n\u00f4n x\u1ea3y ra ti\u1ebfp sau \u0111\u00f3 ch\u1ec9 m\u1edbi \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh tr\u00ean nh\u1eefng tr\u01b0\u1eddng h\u1ee3p b\u1ec7nh nh\u00e2n kh\u00f4ng d\u00f9ng Ondansetron d\u1ef1 ph\u00f2ng tr\u01b0\u1edbc \u0111\u00f3.<\/p>\n<p>Kh\u00f4ng pha lo\u00e3ng thu\u1ed1c khi d\u00f9ng \u0111\u1ec3 d\u1ef1 ph\u00f2ng bu\u1ed3n n\u00f4n\/ n\u00f4n h\u1eadu ph\u1eabu<\/p>\n<p><em>Li\u1ec1u d\u00f9ng cho ng\u01b0\u1eddi gi\u00e0:<\/em><\/p>\n<p>Li\u1ec1u khuy\u1ebfn c\u00e1o d\u00f9ng cho ng\u01b0\u1eddi gi\u00e0 t\u01b0\u01a1ng t\u1ef1 nh\u01b0 ng\u01b0\u1eddi tr\u1ebb tu\u1ed5i.<\/p>\n<p><em>\u0110i\u1ec1u ch\u1ec9nh li\u1ec1u d\u00f9ng cho nh\u1eefng tr\u01b0\u1eddng h\u1ee3p b\u1ec7nh nh\u00e2n b\u1ecb suy th\u1eadn: <\/em><\/p>\n<p>Li\u1ec1u khuy\u1ebfn c\u00e1o t\u01b0\u01a1ng t\u1ef1 nh\u01b0 nh\u1eefng tr\u01b0\u1eddng h\u1ee3p b\u00ecnh th\u01b0\u1eddng.<\/p>\n<p><em>\u0110i\u1ec1u ch\u1ec9nh li\u1ec1u d\u00f9ng cho nh\u1eefng tr\u01b0\u1eddng h\u1ee3p b\u1ec7nh nh\u00e2n b\u1ecb suy gan:<\/em><\/p>\n<p>V\u1edbi nh\u1eefng tr\u01b0\u1eddng h\u1ee3p b\u1ec7nh nh\u00e2n suy gan n\u1eb7ng (\u0111i\u1ec3m Child-Pugh tr\u00ean 10), n\u00ean d\u00f9ng li\u1ec1u \u0111\u01a1n t\u1ed1i \u0111a h\u00e0ng ng\u00e0y l\u00e0 8mg truy\u1ec1n trong th\u1eddi gian 15 ph\u00fat, tr\u01b0\u1edbc khi ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb b\u1eb1ng ph\u00e1c \u0111\u1ed3 ho\u00e1 tr\u1ecb g\u00e2y ra n\u00f4n.<\/p>\n<p><strong>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>Kh\u00f4ng d\u00f9ng thu\u1ed1c ti\u00eam Ondasetron cho nh\u1eefng b\u1ec7nh nh\u00e2n qu\u00e1 m\u1eabn v\u1edbi thu\u1ed1c.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>4.4 Th\u1eadn tr\u1ecdng:<\/strong><\/p>\n<p>C\u1ea3nh b\u00e1o<\/p>\n<p>Kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng bao b\u00ec b\u1eb1ng nh\u1ef1a d\u1ebbo cho vi\u1ec7c d\u1eabn truy\u1ec1n dung d\u1ecbch.<\/p>\n<p>\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh: Thu\u1ed1c ti\u00eam ondanserton \u1ed5n \u0111\u1ecbnh \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng trong \u0111i\u1ec1u ki\u1ec7n \u00e1nh s\u00e1ng th\u01b0\u1eddng trong v\u00f2ng 48 gi\u1edd sau khi pha lo\u00e3ng b\u1eb1ng c\u00e1ch dung d\u1ecbch ti\u00eam t\u0129nh m\u1ea1ch sau: dung d\u1ecbch NaCl 0.9% NaCl, 5% Dextrose, 5% Dextrose v\u00e0 0.9% NaCl, 5% Dextrose v\u00e0 0.45% NaCl, v\u00e0 3% NaCl.<\/p>\n<p>M\u1eb7c d\u00f9 Thu\u1ed1c ti\u00eam Ondansetron \u1ed5n \u0111\u1ecbnh v\u1ec1 m\u1eb7t ho\u00e1 h\u1ecdc v\u00e0 v\u1eadt l\u00fd khi pha lo\u00e3ng v\u1edbi c\u00e1c dung d\u1ecbch ti\u00eam truy\u1ec1n tr\u00ean nh\u01b0ng c\u0169ng c\u1ea7n ph\u1ea3i tu\u00e2n th\u1ee7 c\u00e1c y\u1ebfu t\u1ed1 v\u1ec1 v\u00f4 khu\u1ea9n do c\u00e1c dung d\u1ecbch pha lo\u00e3ng th\u01b0\u1eddng kh\u00f4ng c\u00f3 ch\u1ea5t b\u1ea3o qu\u1ea3n. Kh\u00f4ng d\u00f9ng thu\u1ed1c sau 24 gi\u1edd k\u1ec3 t\u1eeb khi pha lo\u00e3ng.<\/p>\n<p>Ghi ch\u00fa: C\u00e1c thu\u1ed1c ti\u00eam c\u1ea7n ph\u1ea3i \u0111\u01b0\u1ee3c ki\u1ec3m tra b\u1eb1ng m\u1eaft \u0111\u1ec3 ph\u00e1t hi\u1ec7n nh\u1eefng v\u1eadt l\u1ea1 v\u00e0 s\u1ef1 bi\u1ebfn \u0111\u1ed5i m\u00e0u s\u1eafc tr\u01b0\u1edbc khi ti\u00eam.<\/p>\n<p>C\u1ea3nh b\u00e1o: Th\u1ec9nh tho\u1ea3ng c\u00f3 c\u00e1c tinh th\u1ec3 ondansetron b\u00e1m v\u00e0o n\u1eafp\/ th\u00e0nh \u1ed1ng khi u\u1ed1ng thu\u1ed1c b\u1ecb d\u1ed1c ng\u01b0\u1ee3c nh\u01b0ng hi\u1ec7u qu\u1ea3 v\u00e0 an to\u00e0n c\u1ee7a thu\u1ed1c kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng. Trong tr\u01b0\u1eddng h\u1ee3p \u0111\u00f3, l\u1eafc m\u1ea1nh \u1ed1ng thu\u1ed1c \u0111\u1ec3 ondansetron ho\u00e0 tan tr\u1edf l\u1ea1i.<\/p>\n<p>Th\u1eadn tr\u1ecdng khi d\u00f9ng thu\u1ed1c ATOZONE-S<\/p>\n<p><em>Nh\u1eefng l\u01b0u \u00fd \u0111\u1eb7c bi\u1ec7t<\/em><\/p>\n<p>Ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn \u0111\u01b0\u1ee3c ghi nh\u1eadn \u1edf m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed b\u1ecb qu\u00e1 m\u1eabn v\u1edbi c\u00e1c thu\u1ed1c \u0111\u1ed1i kh\u00e1ng ch\u1ecdn l\u1ecdc th\u1ee5 th\u1ec3 5-HT3 kh\u00e1c.<\/p>\n<p><em>Kh\u1ea3 n\u0103ng g\u00e2y ung th\u01b0, \u0111\u1ed9t bi\u1ebfn gen v\u00e0 \u1ea3nh h\u01b0\u1edfng t\u1edbi sinh s\u1ea3n:<\/em><\/p>\n<p>C\u00e1c nghi\u00ean c\u1ee9u ti\u1ebfn h\u00e0nh trong 2 n\u0103m \u0111\u00e1nh gi\u00e1 kh\u1ea3 n\u0103ng g\u00e2y ung th\u01b0 c\u1ee7a ondansetron tr\u00ean chu\u1ed9t nh\u1eaft v\u00e0 chu\u1ed9t b\u1ea1ch khi cho chu\u1ed9t u\u1ed1ng ondansetron v\u1edbi li\u1ec1u t\u01b0\u01a1ng \u1ee9ng l\u00ean t\u1edbi 30mg\/kg\/ng\u00e0y v\u00e0 10mg\/kg\/ng\u00e0y \u0111\u00e3 cho k\u1ebft qu\u1ea3 \u00e2m t\u00ednh. Ondansetron kh\u00f4ng g\u00e2y \u0111\u1ed9t bi\u1ebfn gen trong th\u1eed nghi\u1ec7m chu\u1ea9n. Ondansetron v\u1edbi li\u1ec1u l\u01b0\u1ee3ng l\u00ean t\u1edbi 15mg\/kg\/ng\u00e0y kh\u00f4ng \u1ea3nh h\u01b0\u1edfng t\u1edbi kh\u1ea3 n\u0103ng sinh s\u1ea3n c\u1ee7a chu\u1ed9t b\u1ea1ch c\u00e1i v\u00e0 \u0111\u1ef1c.<\/p>\n<p><em>D\u00f9ng thu\u1ed1c cho tr\u1ebb em<\/em><\/p>\n<p>Hi\u1ec7n c\u00f3 \u00edt th\u00f4ng tin d\u00f9ng thu\u1ed1c cho tr\u1ebb em d\u01b0\u1edbi 1 th\u00e1ng tu\u1ed5i \u0111\u1ec3 ph\u00f2ng n\u00f4n v\u00e0 bu\u1ed3n n\u00f4n sau ph\u1eabu thu\u1eadt. Th\u00f4ng tin v\u1ec1 d\u00f9ng thu\u1ed1c cho tr\u1ebb em d\u01b0\u1edbi 6 th\u00e1ng tu\u1ed5i b\u1ecb ung th\u01b0 c\u0169ng h\u1ea1n ch\u1ebf.<\/p>\n<p>Thanh th\u1ea3i ondansetron \u1edf tr\u1ebb em t\u1eeb 1 t\u1edbi 4 th\u00e1ng tu\u1ed5i ch\u1eadm h\u01a1n v\u00e0 th\u1eddi gian b\u00e1n th\u1ea3i d\u00e0i kho\u1ea3ng 2.5 l\u1ea7n so v\u1edbi \u1edf tr\u1ebb t\u1eeb 4 t\u1edbi 24 th\u00e1ng tu\u1ed5i. Do v\u1eady, c\u1ea7n h\u1ebft s\u1ee9c th\u1eadn tr\u1ecdng khi d\u00f9ng thu\u1ed1c cho tr\u1ebb em d\u01b0\u1edbi 4 th\u00e1ng tu\u1ed5i.<\/p>\n<p>T\u1ea7n su\u1ea5t xu\u1ea5t hi\u1ec7n c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 ghi nh\u1eadn \u1edf tr\u1ebb em khi d\u00f9ng ondansetron c\u0169ng t\u01b0\u01a1ng t\u1ef1 nh\u01b0 nh\u00f3m placebo.<\/p>\n<p><em>D\u00f9ng thu\u1ed1c \u1edf ng\u01b0\u1eddi gi\u00e0<\/em><\/p>\n<p>862 b\u1ec7nh nh\u00e2n tham gia v\u00e0o c\u00e1c th\u1eed nghi\u1ec7m d\u00f9ng ondansetron \u0111\u1ec3 ch\u1ed1ng n\u00f4n v\u00e0 bu\u1ed3n n\u00f4n do ho\u00e1 tr\u1ecb v\u00e0 sau ph\u1eabu thu\u1eadt ti\u1ebfn h\u00e0nh \u1edf M\u1ef9 v\u00e0 nh\u1eefng th\u1eed nghi\u1ec7m ngo\u00e0i n\u01b0\u1edbc M\u1ef9 c\u00f3 \u0111\u1ed9 tu\u1ed5i tr\u00ean 65. N\u00f3i chung, kh\u00f4ng nh\u1eadn th\u1ea5y s\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 an to\u00e0n hay hi\u1ec7u qu\u1ea3 gi\u1eefa nh\u1eefng \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y v\u00e0 nh\u1eefng ng\u01b0\u1eddi tr\u1ebb tu\u1ed5i v\u00e0 nh\u1eefng b\u00e1o c\u00e1o l\u00e2m s\u00e0ng kh\u00e1c c\u0169ng kh\u00f4ng th\u1ea5y c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 \u0111\u00e1p \u1ee9ng thu\u1ed1c gi\u1eefa ng\u01b0\u1eddi gi\u00e0 v\u00e0 ng\u01b0\u1eddi tr\u1ebb nh\u01b0ng m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p, \u1edf ng\u01b0\u1eddi gi\u00e0, m\u1ee9c \u0111\u1ed9 nh\u1ea1y c\u1ea3m v\u1edbi thu\u1ed1c cao. Kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u d\u00f9ng cho b\u1ec7nh nh\u00e2n tr\u00ean 65 tu\u1ed5i.<\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>Trong th\u1eed nghi\u1ec7m, Ondansetron kh\u00f4ng l\u00e0m gi\u1ea3m kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c c\u0169ng kh\u00f4ng g\u00e2y t\u00e1c d\u1ee5ng an th\u1ea7n. Tuy nhi\u00ean thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y \u0111au \u0111\u1ea7u, h\u1ea1 huy\u1ebft \u00e1p v\u00e0 m\u1edd m\u1eaft tho\u00e1ng qua n\u00ean c\u1ea7n th\u1eadn tr\u1ecdng khi l\u00e1i xe ho\u1eb7c v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n<p><strong>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/strong><\/p>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: B1<\/p>\n<p>US FDA pregnancy category: B<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>C\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a thu\u1ed1c t\u1edbi sinh s\u1ea3n \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n tr\u00ean chu\u1ed9t b\u1ea1ch v\u00e0 th\u1ecf mang thai v\u1edbi li\u1ec1u ti\u00eam t\u0129nh m\u1ea1ch l\u00ean t\u1edbi 4mg\/kg\/ng\u00e0y nh\u01b0ng kh\u00f4ng quan s\u00e1t th\u1ea5y \u1ea3nh h\u01b0\u1edfng c\u1ee7a ondansetron t\u1edbi sinh s\u1ea3n v\u00e0 b\u00e0o thai. Tuy nhi\u00ean, hi\u1ec7n ch\u01b0a c\u00f3 c\u00e1c nghi\u00ean c\u1ee9u \u0111\u1ea7y \u0111\u1ee7 v\u00e0 c\u00f3 ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh tr\u00ean ph\u1ee5 n\u1eef mang thai. Do c\u00e1c k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt kh\u00f4ng ph\u1ea3i lu\u00f4n lu\u00f4n cho k\u1ebft qu\u1ea3 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng tr\u00ean ng\u01b0\u1eddi n\u00ean ch\u1ec9 d\u00f9ng thu\u1ed1c cho ph\u1ee5 n\u1eef c\u00f3 thai khi th\u1ef1c s\u1ef1 c\u1ea7n thi\u1ebft.<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>Ondansetron \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua s\u1eefa \u1edf Chu\u1ed9t. Hi\u1ec7n ch\u01b0a bi\u1ebft r\u00f5 Ondansetron c\u00f3 \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua s\u1eefa \u1edf ng\u01b0\u1eddi hay kh\u00f4ng. Do nhi\u1ec1u thu\u1ed1c \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua s\u1eefa n\u00ean c\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng thu\u1ed1c n\u00e0y cho ph\u1ee5 n\u1eef \u0111ang cho con b\u00fa.<\/p>\n<p><strong>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/strong><\/p>\n<p>Khi d\u00f9ng thu\u1ed1c \u0111\u00ea ph\u00f2ng n\u00f4n v\u00e0 ch\u1ed1ng n\u00f4n do ho\u00e1 tr\u1ecb: B\u1ea3ng 1 li\u1ec7t k\u00ea c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 khi d\u00f9ng thu\u1ed1c cho ng\u01b0\u1eddi l\u1edbn v\u1edbi li\u1ec1u d\u00f9ng l\u00e0 0,15 mg\/kg x 3 ho\u1eb7c li\u1ec1u d\u01a1n 32 mg trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng. Nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi ph\u00e1c \u0111\u1ed3 ho\u00e1 tr\u1ecb, ch\u1ee7 y\u1ebfu l\u00e0 cisplatin v\u00e0 truy\u1ec1n d\u1ecbch \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch. H\u1ea7u h\u1ebft c\u00e1c tr\u01b0\u1eddng h\u1ee3p c\u00f3 d\u00f9ng thu\u1ed1c l\u1ee3i ti\u1ec3u.<\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"5\">B\u1ea3ng 1. Nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 ch\u00ednh trong c\u00e1c nghi\u00ean c\u1ee9u so s\u00e1nh \u1edf ng\u01b0\u1eddi l\u1edbn<\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td>C\u00e1c tr\u01b0\u1eddng h\u1ee3p b\u1ecb t\u00e1c d\u1ee5ng ph\u1ee5 Ondansetron 0,15 mg\/kg X 3<\/td>\n<td>Ondansetron\u00a032 mg X 1<\/td>\n<td>Metoclopramide<\/td>\n<td>\u00a0Placebo<\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td>n = 419<\/td>\n<td>n = 220<\/td>\n<td>\u00a0n = 156<\/td>\n<td>n = 34<\/td>\n<\/tr>\n<tr>\n<td>Ti\u00eau ch\u1ea3y<\/td>\n<td>16%<\/td>\n<td>8%<\/td>\n<td>44%<\/td>\n<td>18%<\/td>\n<\/tr>\n<tr>\n<td>\u0110au \u0111\u1ea7u<\/td>\n<td>17%<\/td>\n<td>25%<\/td>\n<td>7%<\/td>\n<td>15%<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1t<\/td>\n<td>8%<\/td>\n<td>7%<\/td>\n<td>5%<\/td>\n<td>3%<\/td>\n<\/tr>\n<tr>\n<td>Ng\u1ed3i, n\u1eb1m kh\u00f4ng y\u00ean<\/td>\n<td>0%<\/td>\n<td>0%<\/td>\n<td>6%<\/td>\n<td>0%<\/td>\n<\/tr>\n<tr>\n<td>R\u1ed1i lo\u1ea1n tr\u01b0\u01a1ng l\u1ef1c c\u1ea5p<\/td>\n<td>0%<\/td>\n<td>0%<\/td>\n<td>5%<\/td>\n<td>0%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Tim m\u1ea1ch: M\u1ed9t s\u1ed1 \u00edt b\u1ecb ch\u1ee9ng \u0111au th\u1eaft ng\u1ef1c, thay \u0111\u1ed3i v\u1ec1 \u0111i\u1ec7n t\u00e2m \u0111\u1ed3, h\u1ea1 huy\u1ebft \u00e1p, v\u00e0 nh\u1ecbp nhanh. Nhi\u1ec1u tr\u01b0\u1eddng h\u1ee3p, s\u1ef1 li\u00ean h\u1ec7 v\u1edbi thu\u1ed1c kh\u00f4ng r\u00f5 r\u00e0ng<\/p>\n<p>D\u1ea1 d\u00e0y- ru\u1ed9t: T\u00e1o b\u00f3n x\u1ea3y ra \u1edf 11% s\u1ed1 b\u1ec7nh nh\u00e2n d\u00f9ng ho\u00e1 tr\u1ecb \u0111\u1ed3ng th\u1eddi v\u1edbi d\u00f9ng ondansetron nhi\u1ec1u ng\u00e0y.<\/p>\n<p>Gan: Trong c\u00e1c th\u1eed nghi\u1ec7m so s\u00e1nh tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n d\u00f9ng cisplatin c\u00f3 k\u00e9t qu\u1ea3 AST v\u00e0 ALT \u1edf m\u1ee9c gi\u1edbi h\u1ea1n b\u00ecnh th\u01b0\u1eddng, kho\u1ea3ng 5% s\u1ed1 b\u1ec7nh nh\u00e2n c\u00f3 n\u1ed3ng \u0111\u1ed9 c\u00e1c enzyme n\u00e0y t\u0103ng g\u1ea5p 2 l\u1ea7n m\u1ee9c gi\u1edbi h\u1ea1n tr\u00ean b\u00ecnh th\u01b0\u1eddng. Hi\u1ec7n t\u01b0\u1ee3ng n\u00e0y ch\u1ec9 tho\u00e1ng qua v\u00e0 kh\u00f4ng li\u00ean quan t\u1edbi li\u1ec1u hay th\u1eddi gian d\u00f9ng thu\u1ed1c. Khi d\u00f9ng li\u1ec1u l\u1eb7p l\u1ea1i, c\u00e1c transaminase t\u0103ng t\u01b0\u01a1ng t\u1ef1 \u1edf m\u1ed9t s\u1ed1 \u0111\u1ee3t d\u00f9ng thu\u1ed1c nh\u01b0ng kh\u00f4ng g\u00e2y ra b\u1ec7nh gan tri\u1ec7u ch\u1ee9ng.<\/p>\n<p>Da li\u1ec5u: Kho\u1ea3ng 1% s\u1ed1 b\u1ec7nh nh\u00e2n d\u00f9ng ondansetron b\u1ecb ban ngo\u00e0i da.<\/p>\n<p>Th\u1ea7n kinh: M\u1ed9t s\u1ed1 \u00edt tr\u01b0\u1eddng h\u1ee3p b\u1ecb ph\u1ea3n \u1ee9ng ngo\u1ea1i th\u00e1p v\u00e0 m\u1ed9t s\u1ed1 \u00edt b\u1ecb \u0111\u1ed9ng kinh l\u1edbn. M\u1ed1i li\u00ean h\u1ec7 c\u1ee7a nh\u01b0ng t\u00e1c d\u1ee5ng ph\u1ee5 n\u00e0y v\u1edbi vi\u1ec7c d\u00f9ng Ondansetron v\u1eabn ch\u01b0a r\u00f5 r\u00e0ng.<\/p>\n<p>C\u00e1c tr\u01b0\u1eddng h\u1ee3p kh\u00e1c: M\u1ed9t s\u1ed1 \u00edt tr\u01b0\u1eddng h\u1ee3p b\u1ecb h\u1ea1 kali m\u00e1u nh\u01b0ng m\u1ed1i li\u00ean h\u1ec7 v\u1edbi d\u00f9ng thu\u1ed1c c\u0169ng ch\u01b0a r\u00f5 r\u00e0ng.<\/p>\n<p>Trong d\u00f9ng thu\u1ed1c \u0111\u1ec3 ph\u00f2ng v\u00e0 ch\u1ed1ng n\u00f4n sau ph\u1eabu thu\u1eadt: Nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 li\u1ec7t k\u00ea \u1edf b\u1ea3ng 2 d\u01b0\u1edbi \u0111\u00e2y x\u1ea3y ra v\u1edbi tan xu\u1ea5t tr\u00ean 2% \u1edf ng\u01b0\u1eddi l\u1edbn d\u00f9ng ondansetron \u0111\u01b0\u1eddng ti\u00eam t\u0129nh m\u1ea1ch v\u1edbi li\u1ec1u 4 mg ti\u00eam trong th\u1eddi gian t\u1eeb 2 t\u1edbi 5 ph\u00fat. S\u1ef1 kh\u00e1c bi\u1ec7t gi\u1eefa nh\u00f3m d\u00f9ng placebo v\u00e0 d\u00f9ng ondansetron kh\u00f4ng \u0111\u00e1ng k\u1ec3<\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"3\">B\u1ea3ng 2. Nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a thu\u1ed1c x\u1ea3y ra \u1edf tr\u00ean 2% s\u1ed1 b\u1ec7nh nh\u00e2n l\u00e0 ng\u01b0\u1eddi l\u1edbn khi d\u00f9ng Ondansetron ti\u00eam t\u0129nh m\u1ea1ch v\u1edbi li\u1ec1u 4 mg, ti\u00eam trong th\u1eddi gian 2-5 ph\u00fat<\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td>Ondansetron 4 mg I.v.<\/td>\n<td>Placebo<\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td>n = 547<\/td>\n<td>n = 547<\/td>\n<\/tr>\n<tr>\n<td>\u0110au \u0111\u1ea7u<\/td>\n<td>92(17%)<\/td>\n<td>77(14%)<\/td>\n<\/tr>\n<tr>\n<td>Ch\u00f3ng m\u1eb7t<\/td>\n<td>67(12%)<\/td>\n<td>88(16%)<\/td>\n<\/tr>\n<tr>\n<td>\u0110au c\u01a1 x\u01b0\u01a1ng<\/td>\n<td>57(10%)<\/td>\n<td>59(11%)<\/td>\n<\/tr>\n<tr>\n<td>M\u01a1 ng\u1ee7\/an th\u1ea7n<\/td>\n<td>44(8%)<\/td>\n<td>37 (7%)<\/td>\n<\/tr>\n<tr>\n<td>R\u00f9ng m\u00ecnh<\/td>\n<td>38 (7%)<\/td>\n<td>39 (7%)<\/td>\n<\/tr>\n<tr>\n<td>Kh\u00f3 ch\u1ecbu\/m\u1ec7t m\u1ecfi<\/td>\n<td>25 (5%)<\/td>\n<td>30 (5%)<\/td>\n<\/tr>\n<tr>\n<td>Ph\u1ea3n \u1ee9ng tai n\u01a1i ti\u00eam<\/td>\n<td>21 (4%)<\/td>\n<td>18(3%)<\/td>\n<\/tr>\n<tr>\n<td>\u1ee8 ti\u1ec3u<\/td>\n<td>17(3%)<\/td>\n<td>15 (3%)<\/td>\n<\/tr>\n<tr>\n<td>\u0110au ng\u1ef1c (kh\u00f4ng \u0111\u1eb7c hi\u1ec7u)<\/td>\n<td>12(2%)<\/td>\n<td>15(3%)<\/td>\n<\/tr>\n<tr>\n<td>Lo l\u1eafng\/k\u00edch \u0111\u1ed9ng<\/td>\n<td>11 (2%)<\/td>\n<td>16(3%)<\/td>\n<\/tr>\n<tr>\n<td>B\u00ed ti\u1ec3u<\/td>\n<td>11 (2%)<\/td>\n<td>9 (2%)<\/td>\n<\/tr>\n<tr>\n<td>H\u1ea1 huy\u1ebft \u00e1p<\/td>\n<td>10(2%)<\/td>\n<td>12(2%)<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1t<\/td>\n<td>10(2%)<\/td>\n<td>6(1%)<\/td>\n<\/tr>\n<tr>\n<td>C\u1ea3m gi\u00e1c l\u1ea1nh<\/td>\n<td>9 (2%)<\/td>\n<td>8(1%)<\/td>\n<\/tr>\n<tr>\n<td>Ng\u1ee9a<\/td>\n<td>9 (2%)<\/td>\n<td>3 (&lt;1%)<\/td>\n<\/tr>\n<tr>\n<td>D\u1ecb c\u1ea3m<\/td>\n<td>9 (2%)<\/td>\n<td>2 (&lt;1%)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>D\u00f9ng thu\u1ed1c cho tr\u1ebb em: Nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n c\u1ee7a thu\u1ed1c \u0111\u01b0\u1ee3c li\u1ec7t k\u00ea \u1edf b\u1ea3ng 3 l\u00e0 nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 th\u01b0\u1eddng g\u1eb7p nh\u1ea5t khi d\u00f9ng ondansetron cho tr\u1ebb em (li\u1ec1u \u0111\u01a1n 0,1 mg\/kg cho tr\u1ebb d\u01b0\u1edbi 40 kg ho\u1eb7c 4 mg cho tr\u1ebb tr\u00ean 40 kg), d\u00f9ng \u0111\u01b0\u1eddng ti\u00eam t\u0129nh m\u1ea1ch v\u1edbi th\u1eddi gian ti\u00eam \u00edt nh\u1ea5t l\u00e0 30 gi\u00e2y. Kh\u00f4ng c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t \u0111\u00e1ng k\u1ec3 \u1edf nh\u00f3m d\u00f9ng thu\u1ed1c v\u00e0 nh\u00f3m d\u00f9ng placebo.<\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"3\">B\u1ea3ng 3. T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n c\u1ee7a thu\u1ed1c trong nh\u1eefng th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng c\u00f3 ki\u1ec3m so\u00e1t v\u1edbi tr\u1ebb em t\u1eeb 2 t\u1edbi 12 tu\u1ed5i.<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1c d\u1ee5ng ph\u1ee5<\/td>\n<td>Ondansetron n = 755<\/td>\n<td>Placebo n = 731<\/td>\n<\/tr>\n<tr>\n<td>v\u1ebft th\u01b0\u01a1ng<\/td>\n<td>80(11%)<\/td>\n<td>86(12%)<\/td>\n<\/tr>\n<tr>\n<td>Lo l\u1eafng, k\u00edch \u0111\u1ed9ng<\/td>\n<td>49 (6%)<\/td>\n<td>47 (6%)<\/td>\n<\/tr>\n<tr>\n<td>\u0110au \u0111\u1ea7u<\/td>\n<td>44 (6%)<\/td>\n<td>43 (6%)<\/td>\n<\/tr>\n<tr>\n<td>M\u01a1 ng\u1ee7, an th\u1ea7n<\/td>\n<td>41 (5%)<\/td>\n<td>56 (8%)<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1t<\/td>\n<td>32 (4%)<\/td>\n<td>41 (6%)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 \u0111\u01b0\u1ee3c li\u1ec7t k\u00ea \u1edf b\u1ea3ng 4 l\u00e0 nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 th\u01b0\u1eddng g\u1eb7p \u1edf Tr\u1ebb t\u1eeb 1 t\u1edbi 24 th\u00e1ng v\u1edbi li\u1ec1u ti\u00eam t\u0129nh m\u1ea1ch 0,1 mg\/kg. Nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 n\u00e0y \u1edf nh\u00f3m d\u00f9ng placebo v\u00e0 ondansetron l\u00e0 nh\u01b0 nhau:<\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"3\">B\u1ea3ng 4. Nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 khi d\u00f9ng thu\u1ed1c cho tr\u1ebb em t\u1eeb 1 t\u1edbi 24 th\u00e1ng (&gt; 2%)<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1c d\u1ee5ng ph\u1ee5<\/td>\n<td>Ondansetron<\/p>\n<p>n-336<\/td>\n<td>Placebo n = 334<\/td>\n<\/tr>\n<tr>\n<td>S\u1ed1t<\/td>\n<td>14(4%)<\/td>\n<td>14 (4%)<\/td>\n<\/tr>\n<tr>\n<td>Co th\u1eaft ph\u1ebf qu\u00e0n<\/td>\n<td>2 (&lt;1%)<\/td>\n<td>6 (2%)<\/td>\n<\/tr>\n<tr>\n<td>\u0110au h\u1eadu ph\u1eabu<\/td>\n<td>4(1%)<\/td>\n<td>6 (2%)<\/td>\n<\/tr>\n<tr>\n<td>Ti\u00eau ch\u1ea3y<\/td>\n<td>6 (2%)<\/td>\n<td>X3 (&lt;1%)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>C\u00e1c ph\u1ea3n \u1ee9ng ph\u1ee5 ghi nh\u1eadn th\u1ef1c t\u1ebf trong th\u1ef1c t\u1ebf l\u00e2m s\u00e0ng, Ngo\u00e0i c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 tron c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng ,c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n sau \u0111\u01b0\u1ee3c ghi nh\u1eadn trong qu\u00e1 tr\u00ecnh l\u01b0u h\u00e0nh thu\u1ed1c c\u1ee7a Ondansetron<\/p>\n<p>Tim m\u1ea1ch: Lo\u1ea1n nh\u1ecbp (bao g\u1ed3m nh\u1ecbp nhanh th\u1ea5t v\u00e0 tr\u00ean th\u1ea5t, co t\u00e2m th\u1ea5t s\u1edbm v\u00e0 rung nh\u0129), ch\u1eadm nh\u1ecbp, thay d\u0111\u1ed5i tr\u00ean \u0111i\u1ec7n t\u00e2m \u0111\u1ed3 (bao g\u1ed3m block tim d\u1ed9 2, \u0111o\u1ea1n ST d\u1eb9t), nh\u1ecbp nhanh v\u00e0 ng\u1ea5t.<\/p>\n<p>To\u00e0n th\u00e2n: \u0110\u1ecf b\u1eebng. M\u1ed9t s\u1ed1 \u00edt tr\u01b0\u1eddng h\u1ee3p b\u1ecb qu\u00e1 m\u1eabn, \u0111\u00f4i khi n\u1eb7ng (nh\u01b0 ph\u1ea3n v\u1ec7, ph\u00f9 Quincke, co th\u1eaft ph\u1ebf qu\u1ea3n, h\u1ea1 huy\u1ebft \u00e1p, ng\u1eebng tim ng\u1eebng th\u1edf, ph\u00f9 thanh qu\u1ea3n, co th\u1eaft thanh qu\u1ea3n, s\u1ed1c, h\u01a1i th\u1edf ng\u1eafn, th\u1edf r\u00edt) c\u0169ng d\u01b0\u1ee3c ghi nh\u1eadn<\/p>\n<p>Gan m\u1eadt: M\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p r\u1ed1i lo\u1ea1n men gan. Suy gan v\u00e0 t\u1eed vong c\u0169ng \u0111\u01b0\u1ee3c ghi nh\u1eadn \u1edf m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p b\u1ec7nh nh\u00e2n b\u1ecb ung th\u01b0 d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c c\u00f3 nguy c\u01a1 g\u00e2y \u0111\u1ed9c cho gan v\u00e0 c\u00e1c kh\u00e1ng sinh. Nguy\u00ean nh\u00e2n c\u1ee7a hi\u1ec7n t\u01b0\u1ee3ng n\u00e0y ch\u01b0a r\u00f5 r\u00e0ng.<\/p>\n<p>Ph\u1ea3n \u1ee9ng t\u1ea1i ch\u1ed7: \u0110au, \u0111\u1ecf v\u00e0 n\u00f3ng t\u1ea1i n\u01a1i ti\u00eam<\/p>\n<p>H\u00f4 h\u1ea5p d\u01b0\u1edbi: N\u1ea5c c\u1ee5c<\/p>\n<p>Th\u1ea7n kinh: C\u01a1n xoay m\u1eaft, xu\u1ea5t hi\u1ec7n ri\u00eang l\u1ebb v\u00e0 \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c ph\u1ea3n \u1ee9ng lo\u1ea1n tr\u01b0\u01a1ng l\u1ef1c c\u01a1.<\/p>\n<p>R\u1ed1i lo\u1ea1n v\u1ec1 m\u1eaft: Nh\u00ecn m\u1edd tho\u00e1ng qua, m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p k\u00e8m theo r\u1ed1i lo\u1ea1n \u0111i\u1ec1u ti\u1ebft. M\u1ed9t s\u1ed1 \u00edt tr\u01b0\u1eddng h\u1ee3p b\u1ecb m\u1ea5t th\u1ecb l\u1ef1c tho\u00e1ng qua, ch\u1ee7 y\u1ebfu x\u1ea3y ra trong khi ti\u00eam. C\u00e1c tr\u01b0\u1eddng h\u1ee3p m\u1ea5t th\u1ecb l\u1ef1c n\u00e0y n\u00f3i chung t\u1ef1 kh\u1ecfi trong kho\u1ea3ng 20 ph\u00fat.<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<p><strong>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/strong><\/p>\n<p>Ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c. V\u1edbi c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i nh\u1eb9, th\u01b0\u1eddng ch\u1ec9 c\u1ea7n ng\u1eebng thu\u1ed1c. Tr\u01b0\u1eddng h\u1ee3p m\u1eabn c\u1ea3m n\u1eb7ng ho\u1eb7c ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, c\u1ea7n ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 (gi\u1eef tho\u00e1ng kh\u00ed v\u00e0 d\u00f9ng epinephrin, th\u1edf oxygen, d\u00f9ng kh\u00e1ng histamin, corticoid&#8230;).<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/strong><\/p>\n<p>B\u1ea3n th\u00e2n Ondansetron kh\u00f4ng g\u00e2y \u1ee9c ch\u1ebf hay k\u00edch th\u00edch enzyme chuy\u1ec3n ho\u00e1 thu\u1ed1c \u1edf gan cytochrome P450. Do ondansetron \u0111\u01b0\u1ee3c chuy\u1ec3n ho\u00e1 b\u1edfi c\u00e1c enzyme CYPp450 (CYP3A4g CYP2D6, CYP1A2) n\u00ean c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf ho\u1eb7c k\u00edch thich nh\u1eefng enzyme n\u00e0y c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng t\u1edbi th\u1ea3i tr\u1eeb thu\u1ed1c, do \u0111\u00f3 \u1ea3nh h\u01b0\u1edfng t\u1edbi th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a thu\u1ed1c. V\u1edbi nh\u1eefng k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u hi\u1ec7n c\u00f3, kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u d\u00f9ng cho nh\u1eefng b\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng c\u00e1c thu\u1ed1c nh\u00f3m tr\u00ean.<\/p>\n<p>Phenytoin, Carbamazepine, v\u00e0 Rifampicin: Khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y k\u00edch th\u00edch CYP3A4 (nh\u01b0 phenytoin, carbamazepine, v\u00e0 rifampicin), th\u1ea3i tr\u1eeb c\u1ee7a ondansetron t\u0103ng l\u00ean \u0111\u00e1ng k\u1ec3, d\u1eabn t\u1edbi n\u1ed3ng \u0111\u1ed9 c\u1ee7a Ondansetron trong m\u00e1u gi\u1ea3m. Tuy nhi\u00ean, v\u1edbi nh\u1eefng k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u hi\u1ec7n c\u00f3, vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u c\u1ee7a ondansetron l\u00e0 kh\u00f4ng khuy\u1ebfn c\u00e1o<\/p>\n<p>Ondansetron kh\u00f4ng \u1ea3nh h\u01b0\u1edfng t\u1edbi t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf h\u00f4 h\u1ea5p c\u1ee7a alfentanil hay ch\u1eb9n th\u1ea7n kinh c\u01a1 c\u1ee7a atracurium. T\u01b0\u01a1ng t\u00e1c thu\u1ed1c v\u1edbi c\u00e1c thu\u1ed1c g\u00e2y m\u00ea c\u1ee5c b\u1ed9 ho\u1eb7c to\u00e0n ph\u1ea7n hi\u1ec7n ch\u01b0a \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u.<\/p>\n<p>Ho\u00e1 tr\u1ecb: \u0110\u00e1p \u1ee9ng m\u00f4 v\u1edbi ho\u00e1 tr\u1ecb trong m\u00f4 h\u00ecnh chu\u1ed9t b\u1ecb t\u0103ng b\u1ea1ch c\u1ea7u P388 kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng khi d\u00f9ng ondansetron. \u1ede ng\u01b0\u1eddi, carmustine, etoposide v\u00e0 cisplatin kh\u00f4ng g\u00e2y \u1ea3nh h\u01b0\u1edfng t\u1edbi d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a ondansetron.<\/p>\n<p>Trong m\u1ed9t nghi\u00ean c\u1ee9u ch\u00e9o v\u1edbi 76 b\u1ec7nh nhi, d\u00f9ng ondansetron \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch kh\u00f4ng \u1ea3nh h\u01b0\u1edfng t\u1edbi n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u c\u1ee7a methotrexate khi d\u00f9ng li\u1ec1u cao.<\/p>\n<p><strong>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/strong><\/p>\n<p>Hi\u1ec7n ch\u01b0a c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u cho Ondansetron. Trong tr\u01b0\u1eddng h\u1ee3p qu\u00e1 li\u1ec1u, \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 l\u00e0 c\u1ea7n thi\u1ebft. M\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p qu\u00e1 li\u1ec1u l\u00ean t\u1edbi 150mg v\u00e0 t\u1ed5ng li\u1ec1u h\u00e0ng ng\u00e0y (3 li\u1ec1u) t\u1edbi 252 mg ti\u00eam t\u0129nh m\u1ea1ch nh\u01b0ng kh\u00f4ng g\u00e2y ra ph\u1ea3n \u1ee9ng ph\u1ee5 nguy hi\u1ec3m n\u00e0o. Nh\u1eefng li\u1ec1u n\u00e0y g\u1ea5p h\u01a1n 10 l\u1ea7n li\u1ec1u d\u00f9ng h\u00e0ng ng\u00e0y khuy\u1ebfn c\u00e1o.<\/p>\n<p>Ngo\u00e0i c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 g\u1eb7p ph\u1ea3i \u1edf tr\u00ean, Nh\u1eefng ph\u1ea3n \u1ee9ng ph\u1ee5 sau \u0111\u01b0\u1ee3c ghi nh\u1eadn khi d\u00f9ng qu\u00e1 li\u1ec1u ondansetron: \u201cM\u00f9 \u0111\u1ed9t ng\u1ed9t\u201d trong 2 t\u1edbi 3 ph\u00fat c\u00f9ng v\u1edbi t\u00e1o b\u00f3n n\u1eb7ng x\u1ea3y ra \u1edf m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p d\u00f9ng ondansetron ti\u00eam t\u0129nh m\u1ea1ch v\u1edbi li\u1ec1u \u0111\u01a1n 72 mg. H\u1ea1 huy\u1ebft \u00e1p (v\u00e0 x\u1ec9u) x\u1ea3y ra \u1edf tr\u01b0\u1eddng h\u1ee3p kh\u00e1c d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng v\u1edbi li\u1ec1u 48mg. Sau khi ti\u00eam Ondansetron v\u1edbi li\u1ec1u 32mg ti\u00eam trong th\u1eddi gian 4 ph\u00fat, ng\u1ea5t k\u00e8m theo block tim \u0111\u1ed9 2 tho\u00e1ng qua c\u0169ng \u0111\u01b0\u1ee3c ghi nh\u1eadn. T\u1ea5t c\u1ea3 c\u00e1c tr\u01b0\u1eddng h\u1ee3p \u0111\u1ec1u t\u1ef1 kh\u1ecfi.<\/p>\n<p><strong>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/strong><\/p>\n<p><strong>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/strong><\/p>\n<p>Ondansetron l\u00e0 thu\u1ed1c \u0111\u1ed1i kh\u00e1ng ch\u1ecdn l\u1ecdc th\u1ee5 th\u1ec3 5-HT3. M\u1eb7c d\u00f9 c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a ondansetron ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh r\u00f5 r\u00e0ng nh\u01b0ng n\u00f3 kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 dopamine. C\u00e1c th\u1ee5 th\u1ec3 serotonine thu\u1ed9c nh\u00f3m 5-HT3 c\u00f3 m\u1eb7t c\u1ea3 \u1edf ngo\u1ea1i vi t\u1ea1i c\u00e1c m\u00fat c\u1ee7a d\u00e2y th\u1ea7n kinh ph\u1ebf v\u1ecb v\u00e0 \u1edf trung t\u00e2m t\u1ea1i v\u00f9ng postrema tr\u00ean s\u00e0n n\u00e3o th\u1ea5t IV. Hi\u1ec7n ch\u01b0a x\u00e1c \u0111\u1ecbnh r\u00f5 r\u00e0ng t\u00e1c d\u1ee5ng ph\u00f2ng ch\u1ed1ng v\u00e0 ch\u1ed1ng n\u00f4n do ho\u00e1 ch\u1ea5t g\u00e2y ra c\u1ee7a ondansetron th\u00f4ng qua t\u00e1c d\u1ee5ng \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 c\u1ee7a serotonine \u1edf th\u1ea7n kinh ngo\u1ea1i vi, trung t\u00e2m hay c\u1ea3 hai. Tuy nhi\u00ean, c\u00e1c ho\u00e1 ch\u1ea5t g\u00e2y \u0111\u1ed9c t\u1ebf b\u00e0o d\u01b0\u1eddng nh\u01b0 c\u00f3 li\u00ean quan t\u1edbi s\u1ef1 gi\u1ea3i ph\u00f3ng serotonine t\u1eeb c\u00e1c t\u1ebf b\u00e0o \u01b0a cr\u00f4m c\u1ee7a ru\u1ed9t non. \u1ede ng\u01b0\u1eddi, s\u1ef1 b\u00e0i ti\u1ebft 5-HIAA t\u1eeb h\u1ec7 ti\u1ebft ni\u1ec7u t\u0103ng l\u00ean sau khi d\u00f9ng cisplatin xu\u1ea5t hi\u1ec7n song song v\u1edbi hi\u1ec7n t\u01b0\u1ee3ng n\u00f4n. S\u1ef1 gi\u1ea3i ph\u00f3ng serotonin c\u00f3 th\u1ec3 k\u00edch th\u00edch th\u1ea7n kinh ph\u1ebf v\u1ecb th\u00f4ng qua th\u1ee5 th\u1ec3 5-HT3 v\u00e0 g\u00e2y n\u00f4n.<\/p>\n<p>Tr\u00ean \u0111\u1ed9ng v\u1eadt, \u0111\u00e1p \u1ee9ng n\u00f4n do cisplatin c\u00f3 th\u1ec3 ng\u0103n ch\u1eb7n b\u1eb1ng vi\u1ec7c \u0111i\u1ec1u tr\u1ecb tr\u01b0\u1edbc b\u1eb1ng thu\u1ed1c \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p serotonin, c\u1eaft d\u00e2y th\u1ea7n kinh ph\u1ebf v\u1ecb hai b\u00ean b\u1ee5ng v\u00e0 c\u1eaft d\u00e2y th\u1ea7n kinh t\u1ea1ng to ho\u1eb7c \u0111i\u1ec1u tr\u1ecb tr\u01b0\u1edbc v\u1edbi c\u00e1c thu\u1ed1c \u0111\u1ed1i kh\u00e1ng th\u1ee5 th\u1ec3 5-HT3.<\/p>\n<p>Tr\u00ean ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n, li\u1ec1u \u0111\u01a1n ondansetron \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch 0,15 mg\/kg kh\u00f4ng g\u00e2y \u1ea3nh h\u01b0\u1edfng t\u1edbi nhu \u0111\u1ed9ng th\u1ef1c qu\u1ea3n, d\u1ea1 d\u00e0y, \u00e1p l\u1ef1c c\u01a1 th\u1eaft th\u1ef1c qu\u1ea3n d\u01b0\u1edbi hay nhu \u0111\u1ed9ng c\u1ee7a ru\u1ed9t non. Trong m\u1ed9t nghi\u00ean c\u1ee9u kh\u00e1c tr\u00ean 6 ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n l\u00e0 nam gi\u1edbi, ondansetron v\u1edbi li\u1ec1u 16 mg ti\u00eam t\u0129nh m\u1ea1ch v\u1edbi th\u1eddi gian ti\u00eam l\u00e0 5 ph\u00fat kh\u00f4ng g\u00e2y \u1ea3nh h\u01b0\u1edfng t\u1edbi hi\u1ec7u su\u1ea5t c\u1ee7a tim, nh\u1ecbp tim, th\u1ec3 t\u00edch t\u00e2m thu, huy\u1ebft \u00e1p hay tr\u00ean \u0111i\u1ec7n t\u00e2m \u0111\u1ed3. D\u00f9ng ondansetron d\u00e0i ng\u00e0y g\u00e2y \u1ea3nh h\u01b0\u1edfng t\u1edbi nhu \u0111\u1ed9ng c\u1ee7a ru\u1ed9t gi\u00e0 \u1edf ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n kho\u1ebb m\u1ea1nh. Thu\u1ed1c kh\u00f4ng \u1ea3nh h\u01b0\u1edfng t\u1edbi n\u1ed3ng \u0111\u1ed9 prolactin trong m\u00e1u.<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>Ondansetron l\u00e0 ch\u1ea5t \u0111\u1ed1i kh\u00e1ng ch\u1ecdn l\u1ecdc th\u1ee5 th\u1ec3 5-HT<sub>3<\/sub> (th\u1ee5 th\u1ec3 serotonin nh\u00f3m 3), c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng n\u00f4n. Thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng c\u1ea3 \u1edf ngo\u1ea1i vi, tr\u00ean \u0111\u1ea7u m\u00fat th\u1ea7n kinh ph\u1ebf v\u1ecb v\u00e0 c\u1ea3 \u1edf trung t\u00e2m, trong v\u00f9ng k\u00edch th\u00edch th\u1ee5 th\u1ec3 h\u00f3a h\u1ecdc.<\/p>\n<p><a href=\"https:\/\/www.youtube.com\/watch?v=I1kZxJHepDY\"><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/a><\/p>\n<p><strong>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/strong><\/p>\n<p>Ondansetron \u0111\u01b0\u1ee3c chuy\u1ec3n ho\u00e1 ho\u00e0n to\u00e0n \u1edf ng\u01b0\u1eddi v\u1edbi kho\u1ea3ng 5% th\u1ea3i tr\u1eeb qua n\u01b0\u1edbc ti\u1ec3u \u1edf nguy\u00ean tr\u1ea1ng. Chuy\u1ec3n ho\u00e1 c\u1ee7a thu\u1ed1c ch\u1ee7 y\u1ebfu l\u00e0 do th\u1ee7y ph\u00e2n c\u1ee7a nh\u00e2n indole sau \u0111\u00f3 li\u00ean h\u1ee3p glucuronide hay sulfate.<\/p>\n<p>M\u1eafc d\u00f9 m\u1ed9t s\u1ed1 ch\u1ea5t chuy\u1ec3n ho\u00e1 kh\u00f4ng li\u00ean h\u1ee3p c\u0169ng c\u00f3 t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd nh\u01b0ng n\u1ed3ng \u0111\u1ed9 trong m\u00e1u kh\u00f4ng \u0111\u00e1ng k\u1ec3 v\u00e0 kh\u00f4ng l\u00e0m t\u0103ng ho\u1ea1t t\u00ednh sinh h\u1ecdc c\u1ee7a ondansetron.<\/p>\n<p>C\u00e1c nghi\u00ean c\u1ee9u in vitro v\u1ec1 chuy\u1ec3n ho\u00e1 cho th\u1ea5y ondansetron l\u00e0 c\u01a1 ch\u1ea5t c\u1ee7a enzyme chuy\u1ec3n ho\u00e1 thu\u1ed1c \u1edf gan Cytochrome P450 bao g\u1ed3m CYP1A2, CYP2D6, v\u00e0 CYP3A4, trong \u0111\u00f3 CYP3A4 \u0111\u00f3ng vai tr\u00f2 ch\u00ednh. Do c\u00f3 nhi\u1ec1u enzyme tham gia v\u00e0o chuy\u1ec3n ho\u00e1 ondansetron n\u00ean s\u1ef1 \u1ee9c ch\u1ebf hay m\u1ea5t m\u1ed9t enzyme (v\u00ed d\u1ee5 nh\u01b0 gi\u1ea3m CYP2D6) s\u1ebd \u0111\u01b0\u1ee3c thay th\u1ebf b\u1edfi m\u1ed9t enzyme kh\u00e1c v\u00e0 th\u1ea3i tr\u1eeb ondansetron, tr\u00ean t\u1ed5ng th\u1ec3, \u1ea3nh h\u01b0\u1edfng kh\u00f4ng \u0111\u00e1ng k\u1ec3. Th\u1ea3i tr\u1eeb c\u1ee7a ondansetron c\u00f3 th\u1ec3 b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi thu\u1ed1c k\u00edch th\u00edch CYP450. Trong m\u1ed9t nghi\u00ean c\u1ee9u d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc tr\u00ean 16 b\u1ec7nh nh\u00e2n \u0111\u1ed9ng kinh d\u00f9ng carmabazepine hay phenytoin k\u00e9o d\u00e0i (c\u00e1c thu\u1ed1c n\u00e0y k\u00edch th\u00edch enzyme CYP450), AUC, Cmax v\u00e0 t1\/2 c\u1ee7a ondansetron gi\u1ea3m. \u0110i\u1ec1u n\u00e0y l\u00e0m cho th\u1ea3i tr\u1eeb c\u1ee7a ondansetron t\u0103ng \u0111\u00e1ng k\u1ec3. Tuy nhi\u00ean, v\u1edbi nh\u1eefng s\u1ed1 li\u1ec7u hi\u1ec7n c\u00f3, vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u c\u1ee7a ondansetron l\u00e0 kh\u00f4ng khuy\u1ebfn c\u00e1o.<\/p>\n<p>\u1ede ng\u01b0\u1eddi, carmustine, etoposide, v\u00e0 cisplatin kh\u00f4ng \u1ea3nh h\u01b0\u1edfng t\u1edbi d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a ondansetron.<\/p>\n<p>V\u1edbi ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n kho\u00e8 m\u1ea1nh, c\u00e1c th\u00f4ng s\u1ed1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh sau khi ti\u00eam li\u1ec1u \u0111\u01a1n 0,15 mg\/kg ondansetron \u0111\u01b0\u1ee3c li\u1ec7t k\u00ea \u1edf b\u1ea3ng d\u01b0\u1edbi:<\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"5\"><strong>B\u1ea3ng 5. C\u00e1c th\u00f4ng s\u1ed1 d\u01b0\u01a1c \u0111\u00f4ng h\u1ecdc \u1edf ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n kho\u1ebb m\u1ea1nh<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>Nh\u00f3m tu\u1ed5i<\/strong><\/td>\n<td><strong>n<\/strong><\/td>\n<td><strong>N\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh c\u1ee7a thu\u1ed1c trong m\u00e1u (ng\/mL)<\/strong><\/td>\n<td><strong>Th\u1eddi gian b\u00e1n th\u1ea3i th\u1ea3i tr\u1eeb trung b\u00ecnh (gi\u1edd)<\/strong><\/td>\n<td><strong>Thanh th\u1ea3i huy\u1ebft t\u01b0\u01a1ng (L\/gi\u1edd\/kg)<\/strong><\/td>\n<\/tr>\n<tr>\n<td>19-40<\/td>\n<td>11<\/td>\n<td>102<\/td>\n<td>3,5<\/td>\n<td>0,381<\/td>\n<\/tr>\n<tr>\n<td>61-74<\/td>\n<td>12<\/td>\n<td>106<\/td>\n<td>4,7<\/td>\n<td>0,319<\/td>\n<\/tr>\n<tr>\n<td>&gt;\/=75<\/td>\n<td>11<\/td>\n<td>170<\/td>\n<td>5,5<\/td>\n<td>0,262<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>V\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n tr\u00ean 75 tu\u1ed5i, thanh th\u1ea3i c\u1ee7a thu\u1ed1c gi\u1ea3m v\u00e0 th\u1eddi gian b\u00e1n th\u1ea3i t\u0103ng. Trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng tr\u00ean b\u1ec7nh nh\u00e2n ung th\u01b0, an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c gi\u1eefa nh\u00f3m b\u1ec7nh nh\u00e2n tr\u00ean v\u00e0 d\u01b0\u1edbi 65 tu\u1ed5i l\u00e0 nh\u01b0 nhau; s\u1ed1 b\u1ec7nh nh\u00e2n tr\u00ean 75 tu\u1ed5i kh\u00f4ng \u0111\u1ee7 \u0111\u1ec3 \u0111i \u0111\u1ebfn k\u1ebft lu\u1eadn cho nh\u00f3m tu\u1ed5i n\u00e0y. Kh\u00f4ng c\u1ea7n thay \u0111\u1ed5i li\u1ec1u d\u00f9ng c\u1ee7a ondansetron \u1edf ng\u01b0\u1eddi gi\u00e0. V\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb suy gan m\u1ee9c \u0111\u1ed9 nh\u1eb9 t\u1edbi trung b\u00ecnh, thanh th\u1ea3i c\u1ee7a thu\u1ed1c gi\u1ea3m kho\u1ea3ng 2 l\u1ea7n v\u00e0 th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh t\u0103ng l\u00ean t\u1edbi 11,6 gi\u1edd so v\u1edbi 5,7 gi\u1edd \u1edf ng\u01b0\u1eddi b\u00ecnh th\u01b0\u1eddng. V\u1edbi nh\u1eefng tr\u01b0\u1eddng h\u1ee3p suy gan n\u1eb7ng hon (\u0111i\u1ec3m Child-Pugh l\u1edbn h\u01a1n 10), thanh th\u1ea3i thu\u1ed1c gi\u1ea3m 2 t\u1edbi 3 l\u1ea7n v\u00e0 th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 t\u0103ng v\u00e0 th\u1eddi gian b\u00e1n th\u1ea3i t\u0103ng l\u00ean t\u1edbi 20 gi\u1edd, V\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb suy gan n\u1eb7ng, kh\u00f4ng n\u00ean d\u00f9ng qu\u00e1 li\u1ec1u 8 mg\/ng\u00e0y.<\/p>\n<p>Do thu\u1ed1c th\u1ea3i tr\u1eeb qua th\u1eadn r\u1ea5t \u00edt (5%) so v\u1edbi t\u1ed5ng th\u1ea3i tr\u1eeb n\u00ean ch\u1ee9c n\u0103ng th\u1eadn kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u00e1ng k\u1ec3 t\u1edbi t\u1ed5ng th\u1ea3i tr\u1eeb c\u1ee7a ondansetron. Tuy nhi\u00ean, thanh th\u1ea3i huy\u1ebft t\u01b0\u01a1ng trung b\u00ecnh c\u1ee7a ondansetron gi\u1ea3m kho\u1ea3ng 41% \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng (thanh th\u1ea3i creatinine &lt; 30 mL\/ph\u00fat). M\u1ee9c \u0111\u1ed9 gi\u1ea3m n\u00e0y kh\u00f4ng \u1ed5n \u0111\u1ecbnh v\u00e0 kh\u00f4ng l\u00e0m t\u0103ng th\u1eddi gian b\u00e1n th\u1ea3i. Kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u hay kho\u1ea3ng li\u1ec1u c\u1ee7a thu\u1ed1c \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y.<\/p>\n<p>\u1ede ng\u01b0\u1eddi l\u1edbn b\u1ecb ung th\u01b0, th\u1eddi gian b\u00e1n th\u1ea3i th\u1ea3i tr\u1eeb c\u1ee7a thu\u1ed1c trung b\u00ecnh l\u00e0 4 gi\u1edd, v\u00e0 kh\u00f4ng c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc \u0111a li\u1ec1u trong kho\u1ea3ng th\u1eddi gian 4 ng\u00e0y. Trong m\u1ed9t nghi\u00ean c\u1ee9u v\u1edbi 21 b\u1ec7nh nh\u00e2n b\u1ecb ung th\u01b0 c\u00f3 tu\u1ed5i t\u1eeb 4 t\u1edbi 18 d\u00f9ng 3 li\u1ec1u ti\u00eam t\u0129nh m\u1ea1ch 0,15 mg\/kg c\u00e1ch nhau 4 gi\u1edd, th\u00f4ng s\u1ed1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a ondansetron \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n tr\u00ean 15 tu\u1ed5i t\u01b0\u01a1ng t\u1ef1 nh\u01b0 \u1edf ng\u01b0\u1eddi l\u1edbn. Nh\u1eefng b\u1ec7nh nh\u00e2n t\u1eeb 4 t\u1edbi 12 tu\u1ed5i n\u00f3i chung, thanh th\u1ea3i c\u1ee7a thu\u1ed1c nhanh h\u01a1n v\u00e0 th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 l\u1edbn h\u01a1n so v\u1edbi ng\u01b0\u1eddi l\u1edbn. V\u1edbi h\u1ea7u h\u1ebft nh\u1eefng b\u1ec7nh nh\u00e2n d\u01b0\u1edbi 15 tu\u1ed5i b\u1ecb ung th\u01b0, th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a thu\u1ed1c ng\u1eafn h\u01a1n (2,4 gi\u1edd) so v\u1edbi \u1edf b\u1ec7nh nh\u00e2n tr\u00ean 15 tu\u1ed5i. Hi\u1ec7n ch\u01b0a bi\u1ebft \u0111\u01b0\u1ee3c r\u1eb1ng s\u1ef1 kh\u00e1c nhau v\u1ec1 th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a ondansetron c\u00f3 d\u1eabn t\u1edbi s\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb \u1edf ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em hay kh\u00f4ng.<\/p>\n<p>C\u00e1c th\u00f4ng s\u1ed1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u00f3 \u0111\u01b0\u1ee3c t\u1eeb 74 tr\u01b0\u1eddng h\u1ee3p b\u1ecb ung th\u01b0 v\u1edbi tu\u1ed5i t\u1eeb 6 th\u00e1ng t\u1edbi 48 th\u00e1ng d\u00f9ng 3 li\u1ec1u ondansetron \u0111\u01b0\u1eddng ti\u00eam t\u0129nh m\u1ea1ch 0,15 mg\/kg c\u00e1ch nhau 4 gi\u1edd trong m\u1ed9t th\u1eed nghi\u1ec7m \u0111\u00e1nh gi\u00e1 t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb. C\u00e1c s\u1ed1 li\u1ec7u n\u00e0y \u0111\u01b0\u1ee3c k\u1ebft h\u1ee3p v\u1edbi k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u sau \u0111\u00f3 tr\u00ean 41 tr\u01b0\u1eddng h\u1ee3p b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c ph\u1eabu thu\u1eadt v\u1edbi tu\u1ed5i t\u1eeb 1 th\u00e1ng t\u1edbi 24 th\u00e1ng d\u00f9ng ondansetron v\u1edbi li\u1ec1u \u0111\u01a1n 0,1 mg\/kg \u0111\u01b0\u1eddng ti\u00eam t\u0129nh m\u1ea1ch tr\u01b0\u1edbc khi ph\u1eabu thu\u1eadt v\u00e0 d\u00f9ng thu\u1ed1c g\u00e2y m\u00ea to\u00e0n th\u00e2n v\u00e0 ng\u01b0\u1eddi ta ti\u1ebfn h\u00e0nh ph\u00e2n t\u00edch k\u1ebft qu\u1ea3 th\u00f4ng s\u1ed1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc tr\u00ean c\u00e1c s\u1ed1 li\u1ec7u \u0111\u00f3. B\u1ea3ng d\u01b0\u1edbi t\u1ed5ng h\u1ee3p c\u00e1c k\u1ebft qu\u1ea3 c\u1ee7a ph\u00e9p ph\u00e2n t\u00edch \u0111\u00f3 v\u00e0 so sanh v\u1edbi th\u00f4ng s\u1ed1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc thu \u0111\u01b0\u1ee3c t\u1eeb nh\u1eefng b\u1ec7nh nh\u00e2n ung th\u01b0 t\u1eeb 4 t\u1edbi 18 tu\u1ed5i.<\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"5\">B\u1ea3ng 6. C\u00e1c th\u00f4ng s\u1ed1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc \u1edf b\u1ec7nh nhi tu\u1ed5i t\u1edbi 8 tu\u1ed5i<\/td>\n<\/tr>\n<tr>\n<td><strong>\u0110\u1ed1i t\u01b0\u1ee3ng v\u00e0 tu\u1ed5i<\/strong><\/td>\n<td><\/td>\n<td><strong>Thanh th\u1ea3i (L\/gi\u1edd\/kg)<\/strong><\/td>\n<td><strong>Vdss<\/strong><\/p>\n<p><strong>(L\/kg)<\/strong><\/td>\n<td><strong>T 1\/2 (h)<\/strong><\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td><\/td>\n<td colspan=\"2\"><strong>Trung b\u00ecnh nh\u00e2n<\/strong><\/td>\n<td><strong>Trung b\u00ecnh<\/strong><\/td>\n<\/tr>\n<tr>\n<td>Tr\u1ebb em bi ung th\u01b0 t\u1eeb 1 th\u00e1ng tu\u1ed1i t\u1edbi 18 tu\u1ed5i<\/td>\n<td>21<\/td>\n<td>0,599<\/td>\n<td>1,9<\/td>\n<td>2,8<\/td>\n<\/tr>\n<tr>\n<td>T\u1ed5ng h\u1ee3p c\u00e1c th\u00f4ng s\u1ed1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a b\u1ec7nh nh\u00e2n t\u1eeb 1 th\u00e1ng tu\u1ed5i t\u1edbi 18 tu\u1ed5i (*)<\/td>\n<td>115<\/td>\n<td>0,582<\/td>\n<td>3,65<\/td>\n<td>4,9<\/td>\n<\/tr>\n<tr>\n<td colspan=\"5\">* 64% b\u1ec7nh nh\u00e2n ung th\u01b0 v\u00e0 36% b\u1ec7nh nh\u00e2n qua ph\u1eabu thu\u1eadt<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Vdss: Th\u1ec3 t\u00edch ph\u00e2n b\u00f4 \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh<\/p>\n<p>D\u1ef1a tr\u00ean c\u00e1c k\u1ebft qu\u1ea3 ph\u00e2n t\u00edch d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a c\u1ea3 hai nh\u00f3m b\u1ec7nh nh\u00e2n, nh\u1eefng b\u1ec7nh nh\u00e2n t\u1eeb 6 th\u00e1ng tu\u1ed5i t\u1edbi 48 th\u00e1ng tu\u1ed5i d\u00f9ng ondansetron v\u1edbi 3 li\u1ec1u 0,15 mg\/kg ti\u00eam t\u0129nh m\u1ea1ch c\u00e1ch nhau 4 gi\u1edd c\u00f3 t\u1ed5ng l\u01b0\u1ee3ng thu\u1ed1c trong m\u00e1u (Di\u1ec7n t\u00edch d\u01b0\u1edbi \u0111\u01b0\u1eddng cong &#8211; AUC) b\u1eb1ng v\u1edbi l\u01b0\u1ee3ng thu\u1ed1c trong m\u00e1u trong c\u00e1c nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00f3 ti\u1ebfn h\u00e0nh tr\u00ean b\u1ec7nh nh\u00e2n ung th\u01b0 (4 t\u1edbi 18 tu\u1ed5i) \u1edf c\u00f9ng m\u1ee9c li\u1ec1u.<\/p>\n<p>Trong m\u1ed9t nghi\u00ean c\u1ee9u tr\u00ean 21 b\u1ec7nh nh\u00e2n (t\u1eeb 3 t\u1edbi 12 tu\u1ed5i) \u0111\u00e3 tr\u1ea3i qua ph\u1eabu thu\u1eadt c\u00f3 g\u00e2y m\u00ea trong th\u1eddi gian t\u1eeb 45 ph\u00fat t\u1edbi 2 gi\u1edd d\u00f9ng ondansetron \u0111on li\u1ec1u \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch 2 mg (cho b\u1ec7nh nh\u00e2n t\u1eeb 3 t\u1edbi 7 tu\u1ed5i) hay 4 mg (cho b\u1ec7nh nh\u00e2n t\u1eeb 8 t\u1edbi 12 tu\u1ed5i) ngay tr\u01b0\u1edbc khi ti\u1ebfn h\u00e0nh g\u00e2y m\u00ea. Thanh th\u1ea3i v\u00e0 th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 c\u1ee7a thu\u1ed1c t\u00ednh theo c\u00e2n n\u1eb7ng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y t\u01b0\u01a1ng t\u1ef1 nh\u01b0 k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00f3 \u1edf ng\u01b0\u1eddi l\u1edbn. Th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh gi\u1ea3m nh\u1eb9 (t\u1eeb 2,5 gi\u1edd t\u1edbi 3 gi\u1edd) so v\u1edbi \u1edf ng\u01b0\u1eddi l\u1edbn (3-3,5 gi\u1edd)<\/p>\n<p>Trong m\u1ed9t nghi\u00ean c\u1ee9u v\u1edbi 51 b\u1ec7nh nhi (t\u1eeb 1 th\u00e1ng tu\u1ed5i t\u1edbi 24 th\u00e1ng tu\u1ed5i) \u0111\u00e3 tr\u1ea3i qua ph\u1eabu thu\u1eadt c\u1ea7n g\u00e2y m\u00ea, ng\u01b0\u1eddi ta d\u00f9ng \u0111\u01a1n li\u1ec1u ondansetron 0,1 ho\u1eb7c 0,2 mg\/kg ti\u00eam t\u0129nh m\u1ea1ch tr\u01b0\u1edbc khi ph\u1eabu thu\u1eadt. C\u00e1c k\u1ebft qu\u1ea3 \u1edf b\u1ea3ng 7 \u0111\u01b0\u1ee3c chia th\u00e0nh 2 nh\u00f3m, m\u1ed9t nh\u00f3m t\u1eeb 1 t\u1edbi 4 th\u00e1ng tu\u1ed5i v\u00e0 nh\u00f3m c\u00f2n l\u1ea1i t\u1eeb 5 t\u1edbi 24 th\u00e1ng tu\u1ed5i v\u00e0 so s\u00e1nh v\u1edbi k\u1ebft qu\u1ea3 th\u00f4ng s\u1ed1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a nh\u00f3m b\u1ec7nh nh\u00e2n t\u1eeb 3 t\u1edbi 12 tu\u1ed3i.<\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"5\">B\u1ea3ng 7. Th\u00f4ng s\u1ed1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a ondansetron \u1edf b\u1ec7nh nh\u00e2n ph\u1eabu thu\u1eadt t\u1eeb 1 th\u00e1ng tu\u1ed5i t\u1edbi 12 tu\u1ed5i<\/td>\n<\/tr>\n<tr>\n<td><strong>\u0110\u1ed1i t\u01b0\u1ee3ng v\u00e0 nh\u00f3m tu\u1ed5i<\/strong><\/td>\n<td><strong>N<\/strong><\/td>\n<td><strong>Thanh th\u1ea3i (L\/gi\u1edd\/kg)<\/strong><\/td>\n<td><strong>Vdss<\/strong><\/p>\n<p><strong>(L\/kg)<\/strong><\/td>\n<td><strong>T1\/2(h)<\/strong><\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td><\/td>\n<td colspan=\"2\"><strong>Trung b\u00ecnh nh\u00e2n<\/strong><\/td>\n<td><strong>Trung b\u00ecnh<\/strong><\/td>\n<\/tr>\n<tr>\n<td>B\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c ph\u1eabu thu\u1eadt, tu\u1ed5i t\u1eeb 3 t\u1edbi 12 tu\u1ed5i<\/td>\n<td>21<\/td>\n<td>0,439<\/td>\n<td>1,65<\/td>\n<td>2,9<\/td>\n<\/tr>\n<tr>\n<td>B\u1ec7nh nhi \u0111\u01b0\u1ee3c ph\u1eabu thu\u1eadt, tu\u1ed5i t\u1eeb 5 t\u1edbi 24 th\u00e1ng<\/td>\n<td>22<\/td>\n<td>0,581<\/td>\n<td>2,3<\/td>\n<td>2,9<\/td>\n<\/tr>\n<tr>\n<td>B\u1ec7nh nhi \u0111\u01b0\u1ee3c ph\u1eabu thu\u1eadt, tu\u1ed5i t\u1eeb 1 t\u1edbi 4 th\u00e1ng<\/td>\n<td>19<\/td>\n<td>0,401<\/td>\n<td>3,5<\/td>\n<td>6,7<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>N\u00f3i chung, \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb ung th\u01b0 ho\u1eb7c ph\u1eabu thu\u1eadt d\u01b0\u1edbi 18 tu\u1ed5i, thanh th\u1ea3i c\u1ee7a ondansetron cao h\u01a1n so v\u1edbi \u1edf ng\u01b0\u1eddi l\u1edbn d\u1eabn t\u1edbi th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a thu\u1ed1c ng\u1eafn h\u01a1n. V\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n t\u1eeb 1 t\u1edbi 4 th\u00e1ng tu\u1ed5i, th\u1eddi gian b\u00e1n th\u1ea3i k\u00e9o d\u00e0i do th\u1ec3 t\u00edch ph\u00e2n b\u00f4 c\u1ee7a thu\u1ed1c \u1edf nh\u00f3m b\u1ec7nh nh\u00e2n n\u00e0y l\u1edbn.<\/p>\n<p>\u1ede ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n kho\u1ebb m\u1ea1nh (19 t\u1edbi 39 tu\u1ed5i, n = 23), n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh c\u1ee7a thu\u1ed1c trong m\u00e1u l\u00e0 264 ng\/mL sau khi d\u00f9ng li\u1ec1u \u0111\u01a1n 32 mg ti\u00eam t\u0129nh m\u1ea1ch v\u1edbi th\u1eddi gian ti\u00eam l\u00e0 15 ph\u00fat. Th\u1eddi gian b\u00e1n th\u1ea3i th\u1ea3i tr\u1eeb trung b\u00ecnh l\u00e0 4,1 gi\u1edd. T\u1ed5ng l\u01b0\u1ee3ng thu\u1ed1c to\u00e0n th\u00e2n \u1edf m\u1ee9c li\u1ec1u 32 mg kh\u00f4ng t\u1ef7 l\u1ec7 v\u1edbi gi\u00e1 tr\u1ecb AUC \u1edf m\u1ee9c li\u1ec1u 8 mg. \u0110i\u1ec1u n\u00e0y ph\u00f9 h\u1ee3p v\u1edbi ghi nh\u1eadn r\u1eb1ng th\u1ea3i tr\u1eeb h\u1ec7 th\u1ed1ng c\u1ee7a thu\u1ed1c gi\u1ea3m kh\u00f4ng \u0111\u00e1ng k\u1ec3 khi n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u t\u0103ng.<\/p>\n<p>M\u1ed9t nghi\u00ean c\u1ee9u th\u1ef1c hi\u1ec7n tr\u00ean ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n kho\u1ebb m\u1ea1nh (n = 56) \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 th\u00f4ng s\u1ed1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a li\u1ec1u \u0111\u01a1n 4 mg ti\u00eam t\u0129nh m\u1ea1ch trong th\u1eddi gian 5 ph\u00fat so v\u1edbi k\u1ebft li\u1ec1u \u0111\u01a1n ti\u00eam b\u1eafp. Di\u1ec7n t\u00edch d\u01b0\u1edbi \u0111\u01b0\u1eddng cong trung b\u00ecnh c\u1ee7a hai nh\u00f3m l\u00e0 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng, 156 [95% CI 136, 180] ng.gi\u1edd\/mL khi d\u00f9ng ti\u00eam t\u0129nh m\u1ea1ch so v\u1edbi 161 [95% CI, 137, 190] ng.gi\u1edd\/mL khi d\u00f9ng ti\u00eam b\u1eafp. N\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh c\u1ee7a thu\u1ed1c trong huy\u1ebft t\u01b0\u01a1ng l\u00e0 42,9 [95% CI 33.8, 54.4] ng\/mL sau 10 ph\u00fat k\u1ec3 t\u1eeb khi truy\u1ec1n t\u0129nh m\u1ea1ch v\u00e0 31,9 [95% CI 26,3; 38,6] ng\/mL sau 41 ph\u00fat khi ti\u00eam b\u1eafp. Th\u1eddi gian b\u00e1n th\u1ea3i th\u1ea3i tr\u1eeb trung b\u00ecnh kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi \u0111\u01b0\u1eddng d\u00f9ng.<\/p>\n<p>T\u1ef7 l\u1ec7 li\u00ean k\u1ebft protein huy\u1ebft t\u01b0\u01a1ng c\u1ee7a ondansetron in vitro t\u1eeb 70% &#8211; 76% v\u00e0 \u1ed5n \u0111\u1ecbnh trong su\u1ed1t kho\u1ea3ng n\u1ed3ng \u0111\u1ed9 \u0111i\u1ec1u tr\u1ecb (10 t\u1edbi 500 ng\/mL). Thu\u1ed1c l\u01b0u th\u00f4ng trong m\u00e1u c\u0169ng ph\u00e2n b\u1ed1 trong h\u1ed3ng c\u1ea7u.<\/p>\n<p><strong>5.3 Gi\u1ea3i th\u00edch: <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong>5.4 Thay th\u1ebf thu\u1ed1c : <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/strong><\/p>\n<p><strong>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/strong><\/p>\n<p>T\u00e1 d\u01b0\u1ee3c: Natri Clorid, Acid Citric, Tri-nitrat citrat dihydrat, N\u01b0\u1edbc pha ti\u00eam<\/p>\n<p><strong>6.2. T\u01b0\u01a1ng k\u1ef5 :<\/strong><\/p>\n<p>Nh\u1eefng thu\u1ed1c sau \u0111\u00e2y c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c d\u00f9ng c\u00f9ng tr\u00ean nh\u00e1nh kia c\u1ee7a d\u00e2y truy\u1ec1n: Cisplatin, carboplatin, etoposid, ceftazidim, cyclophosphamid, doxorubicin, dexamethason v\u00e0 ri\u00eang 5-fluorouracil t\u1edbi n\u1ed3ng \u0111\u1ed9 0,8 mg\/ml. N\u1ebfu d\u00f9ng 5-fluorouracil \u1edf n\u1ed3ng \u0111\u1ed9 cao h\u01a1n, c\u00f3 th\u1ec3 g\u00e2y t\u1ee7a. Kh\u00f4ng n\u00ean tr\u1ed9n ondansetron v\u1edbi dung d\u1ecbch m\u00e0 ch\u01b0a x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c kh\u1ea3 n\u0103ng t\u01b0\u01a1ng h\u1ee3p. \u0110\u1eb7c bi\u1ec7t, dung d\u1ecbch ki\u1ec1m c\u00f3 th\u1ec3 g\u00e2y t\u1ee7a<\/p>\n<p><strong>6.3. B\u1ea3o qu\u1ea3n: <\/strong><\/p>\n<p>B\u1ea3o qu\u1ea3n thu\u1ed1c vi\u00ean v\u00e0 b\u1ed9t pha ti\u00eam \u1edf 2 &#8211; 30 <sup>o<\/sup>C, tr\u00e1nh \u00e1nh s\u00e1ng.<\/p>\n<p><strong>6.4. Th\u00f4ng tin kh\u00e1c :<\/strong><\/p>\n<p>Kh\u00f4ng c\u00f3.<\/p>\n<p><strong>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/strong><\/p>\n<p>D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n<p>Ho\u1eb7c HDSD Thu\u1ed1c.<\/p>\n<p><strong>7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<\/strong><\/p>\n<p>B\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c s\u01b0u t\u1ea7m ho\u1eb7c vi\u1ebft b\u1edfi: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-tac-gia-bac-sy-do-my-linh\/\">B\u00e1c s\u0129 nhi khoa &#8211; \u0110\u1ed7 M\u1ef9 Linh.<\/a><\/p>\n<p>Ki\u1ec3m duy\u1ec7t , hi\u1ec7u \u0111\u00ednh v\u00e0 \u0111\u0103ng t\u1ea3i: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-ve-pharmog-team\/\">PHARMOG TEAM<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Atozone-S, Samtron l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Atozone-S, Samtron (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;) 1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Ondansetron Ph\u00e2n lo\u1ea1i: Thu\u1ed1c ch\u1ed1ng n\u00f4n, [&hellip;]<\/p>\n","protected":false},"author":8612,"featured_media":28352,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[1103],"class_list":["post-28351","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-ondansetron"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/28351","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/8612"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=28351"}],"version-history":[{"count":3,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/28351\/revisions"}],"predecessor-version":[{"id":46667,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/28351\/revisions\/46667"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/28352"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=28351"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=28351"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=28351"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}