{"id":2712,"date":"2018-11-16T15:43:03","date_gmt":"2018-11-16T08:43:03","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=2712"},"modified":"2025-01-08T22:05:44","modified_gmt":"2025-01-08T15:05:44","slug":"filgrastim","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/filgrastim\/","title":{"rendered":"Filgrastim"},"content":{"rendered":"

1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: <\/strong><\/p>\n

Ho\u1ea1t ch\u1ea5t :<\/em> Filgrastim<\/strong><\/p>\n

Ph\u00e2n lo\u1ea1i: <\/em><\/strong>Thu\u1ed1c ta\u0323o ma\u0301u.<\/em> Y\u1ebfu t\u1ed1 k\u00edch th\u00edch t\u0103ng tr\u01b0\u1edfng b\u1ea1ch c\u1ea7u.<\/em><\/p>\n

Nh\u00f3m<\/em><\/strong> ph\u00e1p l\u00fd: <\/em><\/strong>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n

M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): L03AA02.<\/p>\n

Brand name:<\/em><\/strong> Neupogen\u00a0<\/a><\/p>\n

Generic <\/em><\/strong>: Neutromax ,\u00a0Blautrim,\u00a0Hebervital, Ior Leukocim, Leukokine injection<\/a>, Filgen, Ficocyte<\/a>, Grafeel, Gran<\/a> ,\u00a0Neupogen,\u00a0Zarzio<\/a>, Religrast ,\u00a0Kalcogen<\/p>\n

2. D\u1ea1ng b\u00e0o ch\u1ebf – H\u00e0m l\u01b0\u1ee3ng: <\/strong><\/p>\n

D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n

L\u1ecd ho\u1eb7c b\u01a1m ti\u00eam c\u00f3 thu\u1ed1c s\u1eb5n \u0111\u1ec3 ti\u00eam: 30 tri\u1ec7u \u0111v (300 microgam)\/ml; 48 tri\u1ec7u \u0111v (480 microgam)\/1,6 ml; 60 tri\u1ec7u \u0111v (600 microgam)\/ml; 96 tri\u1ec7u \u0111v (960 microgam)\/ml (l\u1ecd 0,5 ml).<\/p>\n

Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n\n\n\n\n\n\n
NEUTROMAX 300MCG\/ML<\/em><\/strong><\/td>\n<\/tr>\n
M\u1ed7i b\u01a1m ti\u00eam s\u1eb5n c\u00f3 ch\u1ee9a:<\/em><\/td>\n<\/td>\n<\/tr>\n
Filgrastim<\/td>\n………………………….<\/td>\n30.M IU<\/td>\n<\/tr>\n
T\u00e1 d\u01b0\u1ee3c<\/td>\n………………………….<\/td>\nv\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\"<\/p>\n

3. Video by Pharmog:<\/strong><\/p>\n

[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n

————————————————<\/p>\n

\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n

\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n

\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n

\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n

\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n

\u25ba Website: pharmog.com<\/p>\n

4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng: <\/strong><\/p>\n

4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n

Ch\u1ee9ng gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh do d\u00f9ng thu\u1ed1c \u1ee9c ch\u1ebf t\u1ee7y (gi\u1ea3m b\u1ea1ch c\u1ea7u c\u00f3 s\u1ed1t) \u1edf b\u1ec7nh nh\u00e2n b\u1ecb u \u00e1c t\u00ednh kh\u00f4ng ph\u1ea3i t\u1ee7y.<\/p>\n

R\u00fat ng\u1eafn th\u1eddi gian ph\u1ee5c h\u1ed3i b\u1ea1ch c\u1ea7u trung t\u00ednh v\u00e0 th\u1eddi gian b\u1ecb s\u1ed1t do \u0111i\u1ec1u tr\u1ecb b\u1eb1ng h\u00f3a ch\u1ea5t \u1edf ng\u01b0\u1eddi b\u1ec7nh b\u1ecb b\u1ea1ch c\u1ea7u c\u1ea5p d\u00f2ng t\u1ee7y. Gi\u1ea3m s\u1ef1 xu\u1ea5t hi\u1ec7n v\u00e0 m\u1ee9c \u0111\u1ed9 c\u1ee7a c\u00e1c h\u1eadu qu\u1ea3 do gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh (s\u1ed1t, nhi\u1ec5m khu\u1ea5n, lo\u00e9t mi\u1ec7ng – h\u1ea7u) \u1edf ng\u01b0\u1eddi b\u1ec7nh m\u1eafc gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh b\u1ea5m sinh, c\u00f3 chu k\u1ef3 ho\u1eb7c kh\u00f4ng r\u00f5 c\u0103n nguy\u00ean. Gi\u1ea3m th\u1eddi gian b\u1ecb gi\u1ea3m b\u1ea1ch c\u1ea7u h\u1ea1t v\u00e0 h\u1eadu qu\u1ea3 \u1edf ng\u01b0\u1eddi b\u1ec7nh \u0111\u01b0\u1ee3c truy\u1ec1n t\u1ee7y t\u1ef1 th\u00e2n ho\u1eb7c \u0111\u1ed3ng lo\u1ea1i.<\/p>\n

Huy \u0111\u1ed9ng t\u1ebf b\u00e0o t\u1ea1o m\u00e1u ra m\u00e1u ngo\u1ea1i vi \u0111\u1ec3 t\u1eadp trung t\u1ebf b\u00e0o trong t\u00e1ch ch\u1ecdn l\u1ecdc b\u1ea1ch c\u1ea7u t\u1eeb m\u00e1u (leukapheresis).<\/p>\n

Gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh do thu\u1ed1c \u1edf ng\u01b0\u1eddi b\u1ec7nh c\u00f3 HIV.<\/p>\n

4.2. Li\u1ec1u d\u00f9ng – C\u00e1ch d\u00f9ng:<\/strong><\/p>\n

C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n

Ti\u00eam d\u01b0\u1edbi da ho\u1eb7c truy\u1ec1n t\u0129nh m\u1ea1ch h\u00e0ng ng\u00e0y trong th\u1eddi gian ng\u1eafn 15 – 60 ph\u00fat. Pha lo\u00e3ng thu\u1ed1c trong dung d\u1ecbch glucose 5%. Ph\u1ea3i ti\u1ebfp t\u1ee5c d\u00f9ng filgrastim cho t\u1edbi khi s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u trung t\u00ednh d\u1ef1 t\u00ednh th\u1ea5p nh\u1ea5t \u0111\u00e3 v\u01b0\u1ee3t qua v\u00e0 s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u trung t\u00ednh \u0111\u00e3 tr\u1edf l\u1ea1i m\u1ee9c b\u00ecnh th\u01b0\u1eddng. Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb c\u1ea7n thi\u1ebft c\u00f3 th\u1ec3 t\u1edbi 14 ng\u00e0y, ph\u1ee5 thu\u1ed9c v\u00e0o typ, li\u1ec1u v\u00e0 th\u1eddi gian d\u00f9ng h\u00f3a tr\u1ecb li\u1ec7u \u0111\u1ed9c t\u1ebf b\u00e0o.<\/p>\n

Pha lo\u00e3ng: N\u1ebfu c\u1ea7n, thu\u1ed1c ti\u00eam filgrastim c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c pha lo\u00e3ng v\u1edbi glucose ti\u00eam 5%. Filgrastim, sau khi \u0111\u00e3 pha lo\u00e3ng \u1edf n\u1ed3ng \u0111\u1ed9 2 – 15 microgam\/ml v\u1edbi glucose ti\u00eam 5% (v\u00e0 c\u00f3 th\u00eam 0,2% albumin ng\u01b0\u1eddi) ho\u1eb7c \u1edf n\u1ed3ng \u0111\u1ed9 l\u1edbn h\u01a1n 15 microgam\/ml trong glucose 5% ph\u00f9 h\u1ee3p v\u1edbi d\u1ee5ng c\u1ee5 b\u01a1m ti\u00eam, ho\u1eb7c b\u1ed9 d\u00e2y truy\u1ec1n l\u00e0m b\u1eb1ng th\u1ee7y tinh ho\u1eb7c nh\u1ef1a plastic th\u01b0\u1eddng d\u00f9ng.<\/p>\n

Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n

V\u1edbi b\u1ec7nh nh\u00e2n h\u00f3a tr\u1ecb li\u1ec7u \u1ee9c ch\u1ebf t\u1ee7y x\u01b0\u01a1ng: Li\u1ec1u khuy\u00ean d\u00f9ng l\u00e0 5 microgam\/kg\/ng\u00e0y, ti\u00eam d\u01b0\u1edbi da 1 l\u1ea7n m\u1ed7i ng\u00e0y; ho\u1eb7c truy\u1ec1n t\u0129nh m\u1ea1ch ch\u1eadm (15 – 30 ph\u00fat) ho\u1eb7c truy\u1ec1n li\u00ean t\u1ee5c d\u01b0\u1edbi da hay truy\u1ec1n t\u0129nh m\u1ea1ch. Kh\u00f4ng \u0111\u01b0\u1ee3c d\u00f9ng filgrastim 24 gi\u1edd tr\u01b0\u1edbc d\u00f9ng h\u00f3a tr\u1ecb li\u1ec7u cho \u0111\u1ebfn 24 gi\u1edd sau khi d\u00f9ng h\u00f3a tr\u1ecb li\u1ec7u v\u00ec c\u00e1c t\u1ebf b\u00e0o t\u1ee7y x\u01b0\u01a1ng \u0111ang ph\u00e2n chia c\u1ef1c k\u1ef3 nh\u1ea1y c\u1ea3m v\u1edbi t\u00e1c d\u1ee5ng \u0111\u1ed9c t\u1ebf b\u00e0o c\u1ee7a c\u00e1c thu\u1ed1c h\u00f3a tr\u1ecb li\u1ec7u ch\u1ed1ng ung th\u01b0.<\/p>\n

V\u1edbi b\u1ec7nh nh\u00e2n ung th\u01b0 \u0111\u01b0\u1ee3c gh\u00e9p t\u1ee7y: Li\u1ec1u khuy\u00ean d\u00f9ng l\u00e0 10 microgam\/kg\/ng\u00e0y truy\u1ec1n t\u0129nh m\u1ea1ch trong 4 ho\u1eb7c 24 gi\u1edd ho\u1eb7c truy\u1ec1n li\u00ean t\u1ee5c d\u01b0\u1edbi da trong 24 gi\u1edd. Ph\u1ea3i d\u00f9ng thu\u1ed1c \u00edt nh\u1ea5t l\u00e0 24 gi\u1edd sau khi d\u00f9ng h\u00f3a tr\u1ecb ho\u1eb7c sau khi truy\u1ec1n t\u1ee7y. Trong th\u1eddi gian ph\u1ee5c h\u1ed3i b\u1ea1ch c\u1ea7u trung t\u00ednh c\u1ea7n theo d\u00f5i s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u v\u00e0 \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u theo b\u1ea3ng d\u01b0\u1edbi \u0111\u00e2y.<\/p>\n

B\u1ea3ng 1: \u0110i\u1ec1u ch\u1ec9nh li\u1ec1u filgrastim trong th\u1eddi k\u1ef3 ph\u1ee5c h\u1ed3i b\u1ea1ch c\u1ea7u h\u1ea1t trung t\u00ednh<\/em><\/p>\n\n\n\n\n\n\n
S\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u h\u1ea1t trung t\u00ednh<\/strong><\/td>\nLi\u1ec1u \u0111i\u1ec1u ch\u1ec9nh<\/strong><\/td>\n<\/tr>\n
Tr\u00ean 1 000\/mm3<\/sup> trong 3 ng\u00e0y li\u00ean ti\u1ebfp<\/td>\nGi\u1ea3m xu\u1ed1ng c\u00f2n 5 microgam\/kg\/ng\u00e0y<\/td>\n<\/tr>\n
v\u1eabn tr\u00ean 1 000\/mm3 <\/sup>trong h\u01a1n 3 ng\u00e0y li\u00ean ti\u1ebfp<\/td>\nNg\u1eebng d\u00f9ng filgrastim<\/td>\n<\/tr>\n
N\u1ebfu gi\u1ea3m t\u1edbi < 1 000\/mm3<\/sup><\/td>\nD\u00f9ng l\u1ea1i li\u1ec1u 5 microgam\/ kg\/ng\u00e0y<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Th\u1eddi gian d\u00f9ng thu\u1ed1c t\u1edbi 2 tu\u1ea7n ho\u1eb7c cho \u0111\u1ebfn khi s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u \u0111\u1ea1t 10 000\/mm3<\/sup><\/p>\n

V\u1edbi b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c gh\u00e9p t\u1ee7y: Ti\u00eam d\u01b0\u1edbi da filgrastim kho\u1ea3ng 10 ng\u00e0y v\u1edbi li\u1ec1u 3, 5, ho\u1eb7c 10 microgam\/kg\/ng\u00e0y. S\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o d\u00f2ng b\u1ea1ch c\u1ea7u h\u1ea1t – \u0111\u1ea1i th\u1ef1c b\u00e0o (GM-CFU) trong m\u00e1u \u0111\u1ea1t t\u1ed1i \u0111a sau 5 ng\u00e0y \u0111i\u1ec1u tr\u1ecb b\u1eb1ng filgrastim. C\u00e1c t\u1ebf b\u00e0o CD34 ph\u00e1t tri\u1ec3n m\u1ea1nh trong kho\u1ea3ng t\u1eeb ng\u00e0y th\u1ee9 4 \u0111\u1ebfn ng\u00e0y th\u1ee9 6. V\u1edbi li\u1ec1u 10 microgam\/kg\/ng\u00e0y, c\u00f3 th\u1ec3 thu th\u1eadp \u0111\u01b0\u1ee3c s\u1ed1 l\u01b0\u1ee3ng 93 x <\/strong>104<\/sup>\/kg GM-CFU b\u1eb1ng c\u00e1ch t\u00e1ch ch\u1ecdn l\u1ecdc b\u1ea1ch c\u1ea7u t\u1eeb m\u00e1u (leukapheresis). Kinh nghi\u1ec7m gh\u00e9p t\u1ef1 th\u00e2n t\u1ebf b\u00e0o ti\u1ec1n th\u00e2n m\u00e1u ngo\u1ea1i vi, cho th\u1ea5y nhu c\u1ea7u GM-CFU t\u1ed1i thi\u1ec3u l\u00e0 50 x <\/strong>104<\/sup>\/kg, n\u00ean vi\u1ec7c t\u00e1ch ch\u1ecdn l\u1ecdc b\u1ea1ch c\u1ea7u t\u1eeb m\u00e1u, d\u00f9ng li\u1ec1u filgrastim 10 microgam\/kg\/ng\u00e0y l\u00e0 \u0111\u1ee7 \u0111\u1ec3 gh\u00e9p \u0111\u1ed3ng lo\u1ea1i.<\/p>\n

\u0110\u1ec3 thu th\u1eadp t\u1ebf b\u00e0o ti\u1ec1n th\u00e2n trong m\u00e1u ngo\u1ea1i vi v\u00e0 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh nh\u00e2n ung th\u01b0: Li\u1ec1u khuy\u00ean d\u00f9ng \u0111\u1ec3 huy \u0111\u1ed9ng t\u1ebf b\u00e0o ti\u1ec1n th\u00e2n trong m\u00e1u ngo\u1ea1i vi l\u00e0 10 microgam\/kg\/ng\u00e0y ti\u00eam d\u01b0\u1edbi da 1 l\u1ea7n ho\u1eb7c truy\u1ec1n li\u00ean t\u1ee5c d\u01b0\u1edbi da. Ph\u1ea3i ti\u00eam \u00edt nh\u1ea5t trong 5 ng\u00e0y tr\u01b0\u1edbc khi t\u00e1ch b\u1ea1ch c\u1ea7u l\u1ea7n \u0111\u1ea7u v\u00e0 ti\u1ebfp t\u1ee5c cho \u0111\u1ebfn l\u1ea7n t\u00e1ch b\u1ea1ch c\u1ea7u cu\u1ed1i c\u00f9ng. V\u1edbi b\u1ec7nh nh\u00e2n b\u1ecb gi\u1ea3m m\u1ea1n t\u00ednh n\u1eb7ng b\u1ea1ch c\u1ea7u trung t\u00ednh: Li\u1ec1u khuy\u00ean d\u00f9ng l\u00e0 6 microgam\/kg\/ng\u00e0y (chia l\u00e0m 2 l\u1ea7n) ti\u00eam d\u01b0\u1edbi da n\u1ebfu l\u00e0 do b\u1ea5m sinh; l\u00e0 5 microgam\/kg\/ng\u00e0y ti\u00eam 1 l\u1ea7n d\u01b0\u1edbi da n\u1ebfu l\u00e0 b\u1ec7nh kh\u00f4ng r\u00f5 nguy\u00ean nh\u00e2n ho\u1eb7c c\u00f3 chu k\u1ef3.<\/p>\n

V\u1edbi ng\u01b0\u1eddi gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh c\u00f3 \u0111\u1ee3t s\u1ed1t trong khi d\u00f9ng h\u00f3a tr\u1ecb li\u1ec7u ch\u1ed1ng ung th\u01b0 cho d\u00f9ng filgrastim v\u1edbi li\u1ec1u 12 microgam\/kg\/ ng\u00e0y, trong v\u00f2ng 12 gi\u1edd sau li\u1ec7u ph\u00e1p tobramycin v\u00e0 piperacilin. V\u1edbi li\u1ec1u n\u00e0y, filgrastim l\u00e0m gi\u1ea3m s\u1ed1 ng\u00e0y b\u1ecb gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh v\u00e0 r\u00fat ng\u1eafn th\u1eddi gian gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh c\u00f3 s\u1ed1t. Filgrastim \u00edch l\u1ee3i l\u1edbn nh\u1ea5t \u0111\u1ed1i v\u1edbi ng\u01b0\u1eddi b\u1ec7nh c\u00f3 bi\u1ec3u hi\u1ec7n nhi\u1ec5m khu\u1ea5n v\u00e0 ng\u01b0\u1eddi b\u1ec7nh c\u00f3 s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u trung t\u00ednh d\u01b0\u1edbi 0,1 x 109<\/sup>\/l\u00edt.<\/p>\n

Filgrastim v\u1edbi li\u1ec1u 12 microgam\/kg\/ng\u00e0y, trong 6 ng\u00e0y ti\u00eam truy\u1ec1n d\u01b0\u1edbi da li\u00ean t\u1ee5c, l\u00e0m t\u0103ng t\u1ebf b\u00e0o ti\u1ec1n th\u00e2n l\u01b0u h\u00e0nh, huy \u0111\u1ed9ng t\u1ebf b\u00e0o ti\u1ec1n th\u00e2n m\u00e1u ngo\u1ea1i vi v\u00e0 ti\u1ec3u c\u1ea7u. S\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o ti\u1ec1n th\u00e2n b\u1ea1ch c\u1ea7u h\u1ea1t – \u0111\u1ea1i th\u1ef1c b\u00e0o \u1edf m\u00e1u ngo\u1ea1i vi c\u00f3 th\u1ec3 t\u0103ng g\u1ea5p 60 l\u1ea7n tr\u01b0\u1edbc \u0111i\u1ec1u tr\u1ecb v\u00e0 s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o ti\u1ec1n th\u00e2n h\u1ed3ng c\u1ea7u c\u00f3 th\u1ec3 t\u0103ng g\u1ea5p 20 \u0111\u1ebfn 25 l\u1ea7n.<\/p>\n

Trong th\u1eddi gian d\u00f9ng thu\u1ed1c ph\u1ea3i theo d\u00f5i th\u00e2n nhi\u1ec7t, c\u00f4ng th\u1ee9c b\u1ea1ch c\u1ea7u, s\u1ed1 l\u01b0\u1ee3ng ti\u1ec3u c\u1ea7u, hematocrit, acid uric m\u00e1u, ph\u00e2n t\u00edch n\u01b0\u1edbc ti\u1ec3u v\u00e0 ch\u1ee9c n\u0103ng gan.<\/p>\n

\u0110\u1ec3 theo d\u00f5i t\u00e1c d\u1ee5ng l\u00ean huy\u1ebft h\u1ecdc c\u1ee7a thu\u1ed1c ph\u1ea3i l\u1ea5y m\u1eabu m\u00e1u \u0111\u1ec3 x\u00e9t nghi\u1ec7m ngay tr\u01b0\u1edbc m\u1ed7i \u0111\u1ee3t d\u00f9ng v\u00e0 \u00edt nh\u1ea5t l\u00e0 2 l\u1ea7n m\u1ed7i tu\u1ea7n.<\/p>\n

4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n

Qu\u00e1 m\u1eabn v\u1edbi filgrastim, v\u1edbi c\u00e1c protein c\u1ee7a E. coli<\/em> ho\u1eb7c v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n

4.4 Th\u1eadn tr\u1ecdng:<\/strong><\/p>\n

Li\u1ec1u filgrastim \u0111\u1ea7u ti\u00ean kh\u00f4ng bao gi\u1edd \u0111\u01b0\u1ee3c d\u00f9ng 24 gi\u1edd tr\u01b0\u1edbc h\u00f3a tr\u1ecb li\u1ec7u v\u00e0 cho \u0111\u1ebfn 24 gi\u1edd sau khi ng\u1eebng h\u00f3a tr\u1ecb li\u1ec7u,<\/p>\n

Thu\u1ed1c c\u00f3 th\u1ec3 l\u00e0m c\u00e1c kh\u1ed1i u ph\u00e1t tri\u1ec3n, nh\u1ea5t l\u00e0 c\u00e1c kh\u1ed1i \u00e1c t\u00ednh c\u1ee7a tu\u1ef7 b\u1edfi v\u1eady ph\u1ea3i th\u1eadn tr\u1ecdng khi d\u00f9ng \u1edf b\u1ec7nh nh\u00e2n c\u00f3 kh\u1ed1i u c\u00f3 \u0111\u1eb7c \u0111i\u1ec3m u t\u1ee7y.<\/p>\n

Khi \u0111\u01b0\u1ee3c d\u00f9ng c\u00f9ng v\u1edbi plerixafor \u0111\u1ec3 huy \u0111\u1ed9ng t\u1ebf b\u00e0o g\u1ed1c, thu\u1ed1c l\u00e0m t\u0103ng b\u1ea1ch c\u1ea7u trong m\u00e1u tu\u1ea7n ho\u00e0n; ph\u1ea3i theo d\u00f5i s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u v\u00e0 th\u1eadn tr\u1ecdng \u1edf b\u1ec7nh nh\u00e2n c\u00f3 s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u > 50 000\/mm3<\/sup>. Do nguy c\u01a1 ti\u1ec1m \u1ea5n t\u0103ng b\u1ea1ch c\u1ea7u trong m\u00e1u, n\u00ean c\u1ea7n ph\u1ea3i theo d\u00f5i s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u. N\u1ebfu s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u t\u0103ng tr\u00ean 50 x 109<\/sup>\/l\u00edt sau khi xu\u1ed1ng th\u1ea5p nh\u1ea5t, ph\u1ea3i ng\u1eebng \u0111i\u1ec1u tr\u1ecb ngay. Kho\u1ea3ng 5% ng\u01b0\u1eddi b\u1ec7nh d\u00f9ng li\u1ec1u b\u00ecnh th\u01b0\u1eddng 3 microgam\/kg\/ng\u00e0y c\u00f3 th\u1ec3 c\u00f3 s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u t\u0103ng tr\u00ean 100 x 109<\/sup>\/l\u00edt. S\u1ed1 l\u01b0\u1ee3ng ti\u1ec3u c\u1ea7u v\u00e0 hematocrit trong m\u00e1u ph\u1ea3i \u0111\u01b0\u1ee3c theo d\u00f5i s\u00e1t sao, c\u00f3 khi ph\u1ea3i \u0111\u1ebfm b\u1ea1ch c\u1ea7u v\u00e0 ti\u1ec3u c\u1ea7u 3 l\u1ea7n\/tu\u1ea7n (tr\u01b0\u1eddng h\u1ee3p ng\u01b0\u1eddi b\u1ec7nh \u0111\u01b0\u1ee3c gh\u00e9p t\u1ee7y) \u0111\u1ec3 theo d\u00f5i s\u1ef1 ph\u1ee5c h\u1ed3i t\u1ee7y.<\/p>\n

Ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng (m\u1ea5n ng\u1ee9a, th\u1edf kh\u00f2 kh\u00e8, kh\u00f3 th\u1edf, tim nhanh, huy\u1ebft \u00e1p h\u1ea1) c\u00f3 th\u1ec3 x\u1ea3y ra \u1edf nh\u1eefng li\u1ec1u \u0111\u1ea7u ti\u00ean ho\u1eb7c nh\u1eefng li\u1ec1u ti\u1ebfp theo v\u00e0 th\u01b0\u1eddng x\u1ea3y ra kho\u1ea3ng 30 ph\u00fat sau khi ti\u00eam ho\u1eb7c truy\u1ec1n t\u0129nh m\u1ea1ch.<\/p>\n

Th\u1eadn tr\u1ecdng khi d\u00f9ng \u1edf ng\u01b0\u1eddi b\u1ec7nh m\u1eafc b\u1ec7nh thi\u1ebfu m\u00e1u h\u1ed3ng c\u1ea7u li\u1ec1m.<\/p>\n

Ng\u01b0\u1eddi b\u1ec7nh c\u00f3 ch\u1ee9c n\u0103ng gan ho\u1eb7c th\u1eadn suy gi\u1ea3m c\u00f3 nhi\u1ec1u nguy c\u01a1 b\u1ecb t\u00e1c d\u1ee5ng ph\u1ee5. Ng\u01b0\u1eddi b\u1ec7nh \u0111\u00e3 t\u1eebng b\u1ecb vi\u00eam m\u1ea1ch ho\u1eb7c c\u00e1c b\u1ec7nh vi\u00eam to\u00e0n th\u00e2n kh\u00e1c c\u0169ng c\u00f3 nhi\u1ec1u nguy c\u01a1 b\u1ecb t\u00e1c d\u1ee5ng ph\u1ee5.<\/p>\n

T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n

C\u1ea7n th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng cho c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n

4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/strong><\/p>\n

X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n

AU TGA pregnancy category: B3<\/p>\n

US FDA pregnancy category: C<\/p>\n

Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n

C\u00f3 m\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u th\u1ef1c nghi\u1ec7m ch\u1ee9ng t\u1ecf filgrastim l\u00e0m t\u0103ng nguy c\u01a1 g\u00e2y t\u1eed vong cho thai nhi. Do \u0111\u00f3, ch\u1ec9 d\u00f9ng filgrastim cho ng\u01b0\u1eddi mang thai khi th\u1ea5y l\u1ee3i \u00edch cho m\u1eb9 h\u01a1n nguy c\u01a1 cho thai.<\/p>\n

Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n

Hi\u1ec7n kh\u00f4ng r\u00f5 filgrastim c\u00f3 \u0111\u01b0\u1ee3c ti\u1ebft qua s\u1eefa hay kh\u00f4ng, do \u0111\u00f3 ph\u1ea3i r\u1ea5t th\u1eadn tr\u1ecdng khi d\u00f9ng cho c\u00e1c b\u00e0 m\u1eb9 \u0111ang cho con b\u00fa.<\/p>\n

4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/strong><\/p>\n

C\u00e1c d\u1eef li\u1ec7u hi\u1ec7n c\u00f3 ch\u1ee9ng t\u1ecf filgrastim \u0111\u01b0\u1ee3c dung n\u1ea1p t\u1ed1t. ADR ph\u1ed1 bi\u1ebfn nh\u1ea5t l\u00e0 \u0111au x\u01b0\u01a1ng nh\u1eb9 \u0111\u1ebfn v\u1eeba, \u1edf kho\u1ea3ng 20% ng\u01b0\u1eddi b\u1ec7nh. \u0110au n\u00e0y th\u01b0\u1eddng c\u00f3 th\u1ec3 gi\u1ea3i quy\u1ebft \u0111\u01b0\u1ee3c b\u1eb1ng c\u00e1c thu\u1ed1c gi\u1ea3m \u0111au m\u00e0 kh\u00f4ng c\u1ea7n ph\u1ea3i ng\u1eebng \u0111i\u1ec1u tr\u1ecb. Lactat dehydrogenase, phosphatase ki\u1ec1m, acid uric v\u00e0 gama-glutamyl-transferase t\u0103ng v\u1eeba trong huy\u1ebft thanh \u1edf 50% s\u1ed1 ng\u01b0\u1eddi \u0111i\u1ec1u tr\u1ecb.<\/p>\n

R\u1ea5t th\u01b0\u1eddng g\u1eb7p, ADR > 10\/100 <\/em><\/p>\n

To\u00e0n th\u00e2n: S\u1ed1t.<\/p>\n

Da: Ph\u1ea3n \u1ee9ng t\u1ea1i ch\u1ed7 ti\u00eam, r\u1ee5ng t\u00f3c, ngo\u1ea1i ban, l\u00e0m n\u1eb7ng th\u00eam b\u1ec7nh da \u0111\u00e3 c\u00f3, xu\u1ea5t huy\u1ebft d\u01b0\u1edbi da.<\/p>\n

L\u00e1ch to.<\/p>\n

Gan: T\u0103ng phosphatase ki\u1ec1m.<\/p>\n

C\u01a1 x\u01b0\u01a1ng: \u0110au c\u01a1, x\u01b0\u01a1ng. Th\u01b0\u1eddng \u0111au \u1edf v\u00f9ng l\u01b0ng d\u01b0\u1edbi, m\u00e0o ch\u1eadu, \u1ee9c. T\u00e1c d\u1ee5ng ph\u1ee5 n\u00e0y ph\u1ee5 thu\u1ed9c v\u00e0o li\u1ec1u d\u00f9ng.<\/p>\n

H\u00f4 h\u1ea5p: Ch\u1ea3y m\u00e1u cam.<\/p>\n

Th\u01b0\u1eddng g\u1eb7p, 1\/100 < ADR < 10\/100<\/em><\/p>\n

Tim m\u1ea1ch: T\u0103ng\/gi\u1ea3m huy\u1ebft \u00e1p, S-T ch\u00eanh, lo\u1ea1n nh\u1ecbp tim, nh\u1ed3i m\u00e1u c\u01a1 tim.<\/p>\n

Th\u1ea7n kinh: Nh\u1ee9c \u0111\u1ea7u.<\/p>\n

Ti\u00eau h\u00f3a: Bu\u1ed3n n\u00f4n, n\u00f4n, \u1ec9a ch\u1ea3y, vi\u00eam ph\u00fac m\u1ea1c.<\/p>\n

M\u00e1u: T\u0103ng b\u1ea1ch c\u1ea7u, b\u1ecb ph\u1ea3n \u1ee9ng khi truy\u1ec1n m\u00e1u.<\/p>\n

\u00cdt g\u1eb7p, ADR <1\/100<\/em><\/p>\n

Suy h\u00f4 h\u1ea5p c\u1ea5p, ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, r\u1ee5ng t\u00f3c, xu\u1ea5t huy\u1ebft ph\u1ebf nang, \u0111au kh\u1edbp, xu\u1ea5t huy\u1ebft n\u00e3o, vi\u00eam m\u1ea1ch da, kh\u00f3 th\u1edf, ph\u00f9 m\u1eb7t, h\u1ed3ng ban n\u00fat, \u0111\u00e1i ra m\u00e1u, ho ra m\u00e1u, gan to, ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn, ph\u1ea3n \u1ee9ng ch\u1ed7 ti\u00eam, lo\u00e3ng x\u01b0\u01a1ng, vi\u00eam m\u00e0ng ngo\u00e0i tim, protein ni\u1ec7u, l\u00e0m b\u1ec7nh v\u1ea5y n\u1ebfn n\u1eb7ng th\u00eam, th\u00e2m nhi\u1ec5m ph\u1ed1i, suy th\u1eadn, v\u1ee1 l\u00e1ch, \u0111\u1ee3t m\u1eafc thi\u1ebfu m\u00e1u h\u1ed3ng c\u1ea7u li\u1ec1m, h\u1ed9i ch\u1ee9ng Sweet (vi\u00eam da s\u1ed1t c\u1ea5p t\u00ednh), nh\u1ecbp tim nhanh, gi\u1ea3m ti\u1ec3u c\u1ea7u, vi\u00eam t\u1eafc t\u0129nh m\u1ea1ch, lo\u1ea1n nh\u1ecbp tim tr\u00ean th\u1ea5t tho\u00e1ng qua, n\u1ed1i m\u00e0y \u0111ay, th\u1edf kh\u00f2 kh\u00e8<\/p>\n

Ch\u00fa \u00fd: \u0110\u00e3 g\u1eb7p protein ni\u1ec7u v\u00e0 huy\u1ebft ni\u1ec7u trong \u0111i\u1ec1u tr\u1ecb l\u00e2u d\u00e0i. C\u00f3 th\u1ec3 th\u1ea5y glucose huy\u1ebft gi\u1ea3m v\u1eeba ph\u1ea3i l\u00fac \u0111\u00f3i. M\u1ed9t s\u1ed1 \u00edt b\u00e1o c\u00e1o nghi ng\u1edd c\u00f3 m\u1ed1i li\u00ean quan gi\u1eefa vi\u1ec7c ph\u00e1t tri\u1ec3n lo\u1ea1n s\u1ea3n t\u1ee7y ho\u1eb7c b\u1ec7nh b\u1ea1ch c\u1ea7u v\u1edbi vi\u1ec7c d\u00f9ng filgrastim \u1edf ng\u01b0\u1eddi gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh b\u1ea5m sinh.<\/p>\n

Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n

4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/strong><\/p>\n

\u0110au x\u01b0\u01a1ng do filgrastim th\u01b0\u1eddng t\u1eeb nh\u1eb9 \u0111\u1ebfn v\u1eeba, c\u00f3 th\u1ec3 ph\u00f2ng ng\u1eeba ho\u1eb7c \u0111i\u1ec1u tr\u1ecb c\u00f3 hi\u1ec7u qu\u1ea3 b\u1eb1ng c\u00e1c thu\u1ed1c u\u1ed1ng gi\u1ea3m \u0111au kh\u00f4ng c\u00f3 thu\u1ed1c phi\u1ec7n (nh\u01b0 paracetamol). Tuy nhi\u00ean c\u0169ng c\u00f3 khi \u0111au x\u01b0\u01a1ng kh\u00e1 n\u1eb7ng, \u0111\u00f2i h\u1ecfi ph\u1ea3i d\u00f9ng c\u00e1c lo\u1ea1i gi\u1ea3m \u0111au opiat v\u00e0 \u0111\u00f4i khi ph\u1ea3i ng\u1eebng \u0111i\u1ec1u tr\u1ecb b\u1eb1ng filgrastim. \u0110au x\u01b0\u01a1ng th\u01b0\u1eddng t\u1ef1 m\u1ea5t \u0111i trong khi v\u1eabn ti\u1ebfp t\u1ee5c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng filgrastim ho\u1eb7c h\u1ebft trong m\u1ed9t th\u1eddi gian ng\u1eafn sau khi k\u1ebft th\u00fac \u0111i\u1ec1u tr\u1ecb b\u1eb1ng filgrastim.<\/p>\n

Trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p n\u1eb7ng, xu\u1ea5t hi\u1ec7n ADR \u1edf da li\u00ean quan \u0111\u1ebfn s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u trung t\u00ednh cao v\u00e0 th\u00e2m nhi\u1ec5m t\u1ea1i ch\u1ed7 c\u00f3 c\u00e1c m\u1ea1ch m\u00e1u vi\u00eam, h\u1eadu qu\u1ea3 c\u1ee7a \u0111i\u1ec1u tr\u1ecb b\u1eb1ng filgrastim. Do v\u1eady \u1edf ng\u01b0\u1eddi b\u1ec7nh \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng filgrastim, c\u1ea7n theo d\u00f5i c\u00e1c ADR tr\u00ean da, v\u00e0 ph\u1ea3i s\u1eed d\u1ee5ng thu\u1ed1c m\u1ed9t c\u00e1ch th\u1eadn tr\u1ecdng \u1edf nh\u1eefng ng\u01b0\u1eddi b\u1ec7nh \u0111\u00e3 b\u1ecb c\u00e1c b\u1ec7nh t\u1ef1 mi\u1ec5n hay vi\u00eam da.<\/p>\n

C\u00e1c ph\u1ea3n \u1ee9ng ki\u1ec3u ph\u1ea3n v\u1ec7 v\u00e0 d\u1ecb \u1ee9ng c\u0169ng th\u01b0\u1eddng g\u1eb7p khi d\u00f9ng filgrastim ti\u00eam t\u0129nh m\u1ea1ch. \u0110a s\u1ed1 c\u00e1c tr\u01b0\u1eddng h\u1ee3p ph\u1ea3n \u1ee9ng x\u1ea3y ra trong v\u00f2ng 30 ph\u00fat \u0111\u1ea7u sau khi ti\u00eam. Tri\u1ec7u ch\u1ee9ng th\u01b0\u1eddng h\u1ebft sau khi d\u00f9ng kh\u00e1ng histamin, steroid, thu\u1ed1c gi\u00e3n ph\u1ebf qu\u1ea3n v\u00e0\/ho\u1eb7c epinephrin (adrenalin), tuy nhi\u00ean c\u00f3 \u0111\u1ebfn tr\u00ean 50% b\u1ecb t\u00e1i ph\u00e1t. Gi\u1ea3m ti\u1ec3u c\u1ea7u, trong \u0111a s\u1ed1 c\u00e1c tr\u01b0\u1eddng h\u1ee3p, \u0111\u01b0\u1ee3c x\u1eed tr\u00ed b\u1eb1ng gi\u1ea3m li\u1ec1u ho\u1eb7c ng\u1eebng d\u00f9ng thu\u1ed1c.<\/p>\n

4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/strong><\/p>\n

Ch\u01b0a c\u00f3 \u0111\u00e1nh gi\u00e1 \u0111\u1ea7y \u0111\u1ee7 t\u01b0\u01a1ng t\u00e1c gi\u1eefa filgrastim v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c. Ph\u1ea3i th\u1eadn tr\u1ecdng khi d\u00f9ng c\u00f9ng v\u1edbi c\u00e1c thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y t\u0103ng gi\u1ea3i ph\u00f3ng b\u1ea1ch c\u1ea7u trung t\u00ednh nh\u01b0 lithi.<\/p>\n

Filgrastim c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 v\u00e0 hi\u1ec7u l\u1ef1c c\u1ee7a topotecan.<\/p>\n

4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/strong><\/p>\n

H\u1eadu qu\u1ea3 c\u1ee7a qu\u00e1 li\u1ec1u filgrastim ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh. Ng\u1eebng filgrastim, b\u1ea1ch c\u1ea7u trung t\u00ednh l\u01b0u h\u00e0nh th\u01b0\u1eddng gi\u1ea3m 50% trong v\u00f2ng 1 – 2 ng\u00e0y v\u00e0 s\u1ebd tr\u1edf l\u1ea1i m\u1ee9c b\u00ecnh th\u01b0\u1eddng tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb trong v\u00f2ng 1 – 7 ng\u00e0y.<\/p>\n

5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/strong><\/p>\n

5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/strong><\/p>\n

Filgrastim l\u00e0 m\u1ed9t y\u1ebfu t\u1ed1 k\u00edch th\u00edch d\u00f2ng b\u1ea1ch c\u1ea7u h\u1ea1t c\u1ee7a ng\u01b0\u1eddi (G-CSF), \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1eb1ng c\u00f4ng ngh\u1ec7 t\u00e1i t\u1ed1 h\u1ee3p DNA c\u00f3 ho\u1ea1t t\u00ednh gi\u1ed1ng ho\u00e0n to\u00e0n y\u1ebfu t\u1ed1 n\u1ed9i sinh k\u00edch th\u00edch d\u00f2ng b\u1ea1ch c\u1ea7u h\u1ea1t c\u1ee7a ng\u01b0\u1eddi.<\/p>\n

Thu\u1ed1c \u0111\u01b0\u1ee3c d\u00f9ng trong l\u00e2m s\u00e0ng \u0111\u1ec3 ph\u00f2ng ng\u1eeba v\u00e0 \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh do nhi\u1ec1u nguy\u00ean nh\u00e2n. Sau khi d\u00f9ng thu\u1ed1c, s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u trung t\u00ednh t\u0103ng \u1edf m\u00e1u ngo\u1ea1i vi trong v\u00f2ng 24 gi\u1edd, v\u00e0 s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u \u0111\u01a1n nh\u00e2n l\u1edbn (monocyt) c\u0169ng t\u0103ng ch\u00fat \u00edt. Trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh m\u1ea1n, \u0111i\u1ec1u tr\u1ecb c\u0169ng l\u00e0m t\u0103ng s\u1ea3n xu\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t \u01b0a eosin v\u00e0 \u01b0a base. T\u0103ng b\u1ea1ch c\u1ea7u h\u1ea1t trung t\u00ednh ph\u1ee5 thu\u1ed9c tr\u1ef1c ti\u1ebfp v\u00e0o li\u1ec1u. Filgrastim c\u00f3 hi\u1ec7u qu\u1ea3 l\u00e0m t\u0103ng s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u trung t\u00ednh v\u00e0 l\u00e0m thuy\u00ean gi\u1ea3m b\u1ec7nh \u1edf ng\u01b0\u1eddi gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh n\u1eb7ng, m\u1ea1n t\u00ednh, bao g\u1ed3m c\u1ea3 h\u1ed9i ch\u1ee9ng Kostmann v\u00e0 gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh chu k\u1ef3, v\u00f4 c\u0103n. Ngo\u00e0i ra, filgrastim kh\u00f4i ph\u1ee5c nhanh b\u1ea1ch c\u1ea7u trung t\u00ednh \u1edf ng\u01b0\u1eddi m\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t do thu\u1ed1c. Khi ng\u1eebng \u0111i\u1ec1u tr\u1ecb, b\u1ea1ch c\u1ea7u h\u1ea1t trung t\u00ednh l\u01b0u h\u00e0nh gi\u1ea3m 50% trong v\u00f2ng 1 – 2 ng\u00e0y v\u00e0 tr\u1edf l\u1ea1i m\u1ee9c b\u00ecnh th\u01b0\u1eddng trong v\u00f2ng 4 – 7 ng\u00e0y. Filgrastim, d\u00f9ng \u0111\u01a1n \u0111\u1ed9c ho\u1eb7c sau h\u00f3a tr\u1ecb li\u1ec7u, huy \u0111\u1ed9ng c\u00e1c t\u1ebf b\u00e0o g\u1ed1c v\u00e0o tu\u1ea7n ho\u00e0n ngo\u1ea1i vi; c\u00f3 th\u1ec3 thu th\u1eadp \u0111\u01b0\u1ee3c c\u00e1c t\u1ebf b\u00e0o n\u00e0y th\u00f4ng qua t\u00e1ch r\u00fat ch\u1ecdn l\u1ecdc b\u1ea1ch c\u1ea7u ra kh\u1ecfi m\u00e1u. Sau \u0111\u00f3 c\u00f3 th\u1ec3 truy\u1ec1n c\u00e1c t\u1ebf b\u00e0o g\u1ed1c ngo\u1ea1i vi n\u00e0y tr\u1ea3 tr\u1edf l\u1ea1i sau khi \u0111i\u1ec1u tr\u1ecb h\u00f3a ch\u1ea5t li\u1ec1u cao thay cho ho\u1eb7c \u0111\u1ec3 b\u1ed1 tr\u1ee3 cho gh\u00e9p t\u1ee7y x\u01b0\u01a1ng t\u1ef1 th\u00e2n, nh\u1eb1m \u0111\u1ea5y nhanh qu\u00e1 tr\u00ecnh h\u1ed3i ph\u1ee5c.<\/p>\n

\u0110i\u1ec1u tr\u1ecb cho tr\u1ebb em v\u00e0 ng\u01b0\u1eddi l\u1edbn b\u1ecb gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh m\u1ea1n (gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh chu k\u1ef3, b\u1ea5m sinh v\u00e0 v\u00f4 c\u0103n) l\u00e0m t\u0103ng b\u1ea1ch c\u1ea7u trung t\u00ednh l\u01b0u h\u00e0nh trong m\u00e1u ngo\u1ea1i vi v\u00e0 gi\u1ea3m nguy c\u01a1 nhi\u1ec5m khu\u1ea5n.<\/p>\n

Filgrastim v\u1edbi li\u1ec1u 230 microgam\/m2<\/sup> di\u1ec7n t\u00edch da\/ng\u00e0y, l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 t\u1ef7 l\u1ec7, th\u1eddi gian v\u00e0 m\u1ee9c \u0111\u1ed9 n\u1eb7ng c\u1ee7a gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh \u1edf ng\u01b0\u1eddi \u0111ang d\u00f9ng h\u00f3a tr\u1ecb li\u1ec7u li\u1ec1u th\u00f4ng th\u01b0\u1eddng v\u1edbi c\u00e1c thu\u1ed1c nh\u01b0 cyclophosphamid, doxorubicin k\u00e8m v\u1edbi etoposid.<\/p>\n

C\u00f9ng v\u1edbi s\u1ef1 c\u1ea3i thi\u1ec7n gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh, t\u1ef7 l\u1ec7 gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh c\u00f3 s\u1ed1t c\u00f3 th\u1ec3 gi\u1ea3m kho\u1ea3ng 50%. T\u1ef7 l\u1ec7 n\u1eb1m vi\u1ec7n v\u00e0 nhu c\u1ea7u \u0111i\u1ec1u tr\u1ecb b\u1eb1ng kh\u00e1ng sinh t\u0129nh m\u1ea1ch c\u0169ng gi\u1ea3m theo t\u1ef7 l\u1ec7 t\u01b0\u01a1ng \u1ee9ng.<\/p>\n

V\u00ec kh\u00f4ng ph\u1ea3i t\u1ea5t c\u1ea3 c\u00e1c ng\u01b0\u1eddi b\u1ec7nh d\u00f9ng h\u00f3a tr\u1ecb li\u1ec7u v\u1edbi li\u1ec1u th\u00f4ng th\u01b0\u1eddng c\u00f3 nguy c\u01a1 bi\u1ebfn ch\u1ee9ng nhi\u1ec5m khu\u1ea5n, n\u00ean filgrastim \u0111\u01b0\u1ee3c d\u00e0nh cho c\u00e1c tr\u01b0\u1eddng h\u1ee3p \u0111\u00e3 b\u1ecb gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh c\u00f3 s\u1ed1t trong m\u1ed9t li\u1ec7u tr\u00ecnh h\u00f3a tr\u1ecb li\u1ec7u tr\u01b0\u1edbc \u0111\u00f3. Nh\u01b0 v\u1eady, khi ph\u1ed1i h\u1ee3p v\u1edbi li\u1ec7u ph\u00e1p kh\u00e1ng sinh t\u0129nh m\u1ea1ch th\u00f4ng th\u01b0\u1eddng, filgrastim l\u00e0m thuy\u00ean gi\u1ea3m b\u1ec7nh \u1edf ng\u01b0\u1eddi \u0111\u00e3 b\u1ecb gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh c\u00f3 s\u1ed1t v\u00e0 c\u00f3 t\u00e1c d\u1ee5ng t\u1ed1t l\u00e0 r\u00fat ng\u1eafn th\u1eddi gian n\u1eb1m vi\u1ec7n.<\/p>\n

C\u1ea7n ch\u00fa \u00fd s\u1eed d\u1ee5ng c\u00e1c y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng t\u1ea1o m\u00e1u nh\u1eb1m h\u1ed7 tr\u1ee3 h\u00f3a tr\u1ecb li\u1ec7u li\u1ec1u cao \u0111\u1ec3 c\u1ea3i thi\u1ec7n k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb ng\u01b0\u1eddi b\u1ecb kh\u1ed1i u, c\u00f3 \u0111\u00e1p \u1ee9ng v\u1edbi h\u00f3a tr\u1ecb li\u1ec7u. Filgrastim d\u00f9ng \u0111\u01a1n \u0111\u1ed9c cho ph\u00e9p t\u0103ng nh\u1eb9 li\u1ec1u v\u00e0\/ho\u1eb7c t\u0103ng d\u1ea7n li\u1ec1u trong m\u1ed9t s\u1ed1 ph\u00e1c \u0111\u1ed3 h\u00f3a tr\u1ecb li\u1ec7u th\u00f4ng th\u01b0\u1eddng. H\u01a1n n\u1eefa, thu\u1ed1c \u0111\u00e3 ch\u1ee9ng t\u1ecf c\u00f3 \u00edch nh\u01b0 m\u1ed9t thu\u1ed1c b\u1ed1 tr\u1ee3 cho h\u00f3a tr\u1ecb li\u1ec7u \u1ee9c ch\u1ebf t\u1ee7y k\u00e8m theo vi\u1ec7c thu th\u1eadp t\u1ebf b\u00e0o g\u1ed1c \u0111\u1ec3 gh\u00e9p t\u1ee7y x\u01b0\u01a1ng t\u1ef1 th\u00e2n, v\u00e0\/ho\u1eb7c truy\u1ec1n c\u00e1c t\u1ebf b\u00e0o ti\u1ec1n th\u00e2n m\u00e1u ngo\u1ea1i vi.<\/p>\n

C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n

Thu\u1ed1c \u0111i\u1ec1u h\u00f2a vi\u1ec7c s\u1ea3n xu\u1ea5t v\u00e0 huy \u0111\u1ed9ng c\u00e1c b\u1ea1ch c\u1ea7u h\u1ea1t trung t\u00ednh t\u1eeb t\u1ee7y x\u01b0\u01a1ng v\u00e0 c\u00f3 th\u1ec3 \u1edf c\u1ea3 n\u01a1i kh\u00e1c nh\u01b0 l\u00e1ch. Thu\u1ed1c g\u1eafn v\u00e0o c\u00e1c th\u1ee5 th\u1ec3 \u0111\u1eb7c hi\u1ec7u tr\u00ean b\u1ec1 m\u1eb7t c\u1ee7a c\u00e1c t\u1ebf b\u00e0o t\u1ea1o m\u00e1u, k\u00edch th\u00edch s\u1ef1 ho\u1ea1t h\u00f3a, t\u0103ng sinh v\u00e0 bi\u1ec7t h\u00f3a c\u00e1c t\u1ebf b\u00e0o ti\u1ec1n th\u00e2n b\u1ea1ch c\u1ea7u trung t\u00ednh, l\u00e0m t\u0103ng s\u1ef1 di chuy\u1ec3n v\u00e0 kh\u1ea3 n\u0103ng th\u1ef1c b\u00e0o c\u1ee7a b\u1ea1ch c\u1ea7u h\u1ea1t trung t\u00ednh.<\/p>\n

[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/p>\n

5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/strong><\/p>\n

H\u1ea5p thu v\u00e0 thanh th\u1ea3i filgrastim theo ki\u1ec3u d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc b\u1eadc m\u1ed9t m\u00e0 kh\u00f4ng ph\u1ee5 thu\u1ed9c r\u00f5 v\u00e0o n\u1ed3ng \u0111\u1ed9. C\u00f3 m\u1ed1i t\u01b0\u01a1ng quan tuy\u1ebfn t\u00ednh thu\u1eadn gi\u1eefa li\u1ec1u ti\u00eam v\u00e0 n\u1ed3ng \u0111\u1ed9 filgrastim trong huy\u1ebft thanh, d\u00f9 ti\u00eam t\u0129nh m\u1ea1ch hay ti\u00eam d\u01b0\u1edbi da. Sau khi ti\u00eam d\u01b0\u1edbi da, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t \u0111\u01b0\u1ee3c sau 2 – 6 gi\u1edd. Sau khi ti\u00eam d\u01b0\u1edbi da v\u1edbi li\u1ec1u khuy\u1ebfn c\u00e1o, n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft thanh \u0111\u01b0\u1ee3c duy tr\u00ec tr\u00ean 10 nanogam\/ml, trong 8 \u0111\u1ebfn 16 gi\u1edd. Truy\u1ec1n t\u0129nh m\u1ea1ch li\u00ean t\u1ee5c 24 gi\u1edd v\u1edbi li\u1ec1u 20 microgam\/kg, trong 11 \u0111\u1ebfn 20 ng\u00e0y, cho n\u1ed3ng \u0111\u1ed9 filgrastim on \u0111\u1ecbnh trong huy\u1ebft thanh v\u00e0 kh\u00f4ng th\u1ea5y thu\u1ed1c t\u00edch l\u0169y trong th\u1eddi gian kh\u1ea3o s\u00e1t (11 – 20 ng\u00e0y).<\/p>\n

Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 trung b\u00ecnh 150 ml\/kg \u1edf c\u1ea3 ng\u01b0\u1eddi b\u00ecnh th\u01b0\u1eddng v\u00e0 ng\u01b0\u1eddi m\u1eafc ung th\u01b0. N\u1eeda \u0111\u1eddi th\u1ea3i tr\u1eeb \u1edf c\u1ea3 ng\u01b0\u1eddi b\u00ecnh th\u01b0\u1eddng v\u00e0 ng\u01b0\u1eddi m\u1eafc ung th\u01b0 l\u00e0 1,8 – 3,5 gi\u1edd, \u1edf tr\u1ebb s\u01a1 sinh l\u00e0 4,4 gi\u1edd.<\/p>\n

Trong v\u00f2ng 24 gi\u1edd sau khi ti\u00eam, s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u trung t\u00ednh t\u0103ng nhanh ch\u00f3ng v\u00e0 \u0111\u1ea1t \u0111\u1ec9nh sau 3 – 5 ng\u00e0y. Sau 2 ng\u00e0y ng\u1eebng d\u00f9ng thu\u1ed1c, s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u trung t\u00ednh gi\u1ea3m \u0111i 50% v\u00e0 tr\u1edf v\u1ec1 m\u1ee9c b\u00ecnh th\u01b0\u1eddng trong v\u00f2ng 4 – 7 ng\u00e0y.<\/p>\n

Ng\u01b0\u1eddi ta ch\u01b0a x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c \u0111\u1ea7y \u0111\u1ee7 s\u1ef1 chuy\u1ec3n h\u00f3a c\u1ee7a filgrastim v\u00e0 kh\u00f4ng bi\u1ebft thu\u1ed1c \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a ho\u1eb7c \u0111ao th\u1ea3i nh\u01b0 th\u1ebf n\u00e0o.<\/p>\n

5.3 Gi\u1ea3i th\u00edch: <\/strong><\/p>\n

Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n

5.4 Thay th\u1ebf thu\u1ed1c : <\/strong><\/p>\n

Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n

*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n

C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o – Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n

Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n

6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/strong><\/p>\n

6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/strong><\/p>\n

Sodium Acetate*, Sorbitol (E420), Polysorbate 80, Water for Injections<\/p>\n

*Sodium acetate is formed by titrating glacial acetic acid with sodium hydroxide<\/p>\n

6.2. T\u01b0\u01a1ng k\u1ef5 :<\/strong><\/p>\n

Filgrastim ti\u00eam kh\u00f4ng \u0111\u01b0\u1ee3c pha v\u1edbi dung d\u1ecbch mu\u1ed1i, v\u00ec c\u00f3 th\u1ec3 g\u00e2y t\u1ee7a.<\/p>\n

6.3. B\u1ea3o qu\u1ea3n: <\/strong><\/p>\n

Filgrastim ti\u00eam ph\u1ea3i b\u1ea3o qu\u1ea3n trong t\u1ee7 l\u1ea1nh \u1edf nhi\u1ec7t \u0111\u1ed9 2 – 8 o<\/sup>C; kh\u00f4ng \u0111\u01b0\u1ee3c l\u00e0m \u0111\u00f4ng l\u1ea1nh. Nh\u00e0 s\u1ea3n xu\u1ea5t th\u00f4ng b\u00e1o b\u1ea5t c\u1ee9 l\u1ecd thu\u1ed1c n\u00e0o \u0111\u1ec3 \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng qu\u00e1 24 gi\u1edd ph\u1ea3i lo\u1ea1i b\u1ecf. Tr\u00e1nh \u00e1nh n\u1eafng tr\u1ef1c ti\u1ebfp nh\u01b0ng kh\u00f4ng c\u1ea7n ph\u1ea3i b\u1ea3o v\u1ec7 ch\u1ed1ng \u00e1nh s\u00e1ng b\u00ecnh th\u01b0\u1eddng trong ph\u00f2ng.<\/p>\n

Kh\u00f4ng pha dung d\u1ecbch filgrastim v\u1edbi dung d\u1ecbch natri clorid v\u00ec s\u1ebd g\u00e2y k\u1ebft t\u1ee7a. C\u00f3 th\u1ec3 pha lo\u00e3ng v\u1edbi dung d\u1ecbch glucose 5% nh\u01b0ng v\u00ec th\u1ee7y tinh v\u00e0 ch\u1ea5t d\u1ebbo h\u1ea5p ph\u1ee5 filgrastim, kh\u00f4ng n\u00ean pha dung d\u1ecbch c\u00f3 n\u1ed3ng \u0111\u1ed9 < 2 microgam\/ml. C\u0169ng v\u1eady, \u0111\u1ec3 tr\u00e1nh h\u1ea5p ph\u1ee5, c\u00e1c dung d\u1ecbch d\u01b0\u1edbi 15 microgam\/ml n\u00ean th\u00eam albumin \u0111\u1ebfn n\u1ed3ng \u0111\u1ed9 cu\u1ed1i c\u00f9ng l\u00e0 2 mg\/ml.<\/p>\n

6.4. Th\u00f4ng tin kh\u00e1c :<\/strong><\/p>\n

Kh\u00f4ng c\u00f3.<\/p>\n

6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/strong><\/p>\n

D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n

Ho\u1eb7c HDSD Thu\u1ed1c.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Filgrastim Ph\u00e2n lo\u1ea1i: Thu\u1ed1c ta\u0323o ma\u0301u. Y\u1ebfu t\u1ed1 k\u00edch th\u00edch t\u0103ng tr\u01b0\u1edfng b\u1ea1ch c\u1ea7u. Nh\u00f3m ph\u00e1p l\u00fd: Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine) M\u00e3 ATC (Anatomical Therapeutic Chemical): L03AA02. Brand name: Neupogen\u00a0 Generic : Neutromax ,\u00a0Blautrim,\u00a0Hebervital, Ior Leukocim, Leukokine […]<\/p>\n","protected":false},"author":1,"featured_media":23509,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[2],"tags":[806],"class_list":["post-2712","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-thuoc-a-z","tag-filgrastim"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/2712","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=2712"}],"version-history":[{"count":3,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/2712\/revisions"}],"predecessor-version":[{"id":23511,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/2712\/revisions\/23511"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/23509"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=2712"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=2712"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=2712"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}