{"id":27034,"date":"2020-12-31T16:48:54","date_gmt":"2020-12-31T09:48:54","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=27034"},"modified":"2025-01-08T12:24:14","modified_gmt":"2025-01-08T05:24:14","slug":"gabapentin-gabalept-microleptin","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/gabapentin-gabalept-microleptin\/","title":{"rendered":"Gabapentin &#8211; Gabalept\/Microleptin"},"content":{"rendered":"<p><em>Thu\u1ed1c Gabalept , Microleptin l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Gabalept , Microleptin (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;)<\/em><\/p>\n<p><strong>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: <\/strong><\/p>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <\/strong><a href=\"https:\/\/pharmog.com\/wp\/gabapentin\/\"><strong>Gabapentin<\/strong><\/a><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh, \u0111i\u1ec1u tr\u1ecb \u0111au th\u1ea7n kinh<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): NO3AX12.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em><\/strong> <a href=\"https:\/\/pharmog.com\/wp\/gabapentin-neurontin\/\">Neurontin <\/a><\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c:<\/em><\/strong> Gabalept , Microleptin<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: Micro Labs Limited<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng: <\/strong><\/p>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>Vi\u00ean nang: 300 mg.<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>GABALEPT 300mg<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean nang c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Gabapentin<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>300 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"523\" height=\"404\" class=\"wp-image-27035\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/12\/word-image-319.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/12\/word-image-319.png 523w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/12\/word-image-319-300x232.png 300w\" sizes=\"auto, (max-width: 523px) 100vw, 523px\" \/><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>MICROLEPTIN<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean nang c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Gabapentin<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>300 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"338\" height=\"322\" class=\"wp-image-27036\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/12\/word-image-320.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/12\/word-image-320.png 338w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/12\/word-image-320-300x286.png 300w\" sizes=\"auto, (max-width: 338px) 100vw, 338px\" \/><\/p>\n<p><strong>3. Video by Pharmog:<\/strong><\/p>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<p><strong>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng: <\/strong><\/p>\n<p><strong>4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>\u0110i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 trong \u0111\u1ed9ng kinh c\u1ee5c b\u1ed9.<\/p>\n<p>Gabapentin c\u00f2n \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb \u0111au do vi\u00eam c\u00e1c d\u00e2y th\u1ea7n kinh ngo\u1ea1i bi\u00ean.<\/p>\n<p><strong>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/strong><\/p>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p>D\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng, th\u1eddi \u0111i\u1ec3m u\u1ed1ng thu\u1ed1c kh\u00f4ng ph\u1ee5 thu\u1ed9c v\u00e0o b\u1eefa \u0103n.<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p><em>Ch\u1ed1ng \u0111\u1ed9ng kinh:<\/em><\/p>\n<p><em>Ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em tr\u00ean 12 tu\u1ed5i:<\/em><\/p>\n<p>Ng\u00e0y \u0111\u1ea7u: 300 mg.<\/p>\n<p>Ng\u00e0y th\u1ee9 2: 300 mg\/l\u1ea7n x 2 l\u1ea7n.<\/p>\n<p>Ng\u00e0y th\u1ee9 3: 300 mg\/l\u1ea7n x 3 l\u1ea7n.<\/p>\n<p>Sau \u0111\u00f3 li\u1ec1u c\u00f3 th\u1ec3 t\u0103ng th\u00eam t\u1eebng b\u01b0\u1edbc 300 mg m\u1ed7i ng\u00e0y, d\u1ef1a tr\u00ean \u0111\u00e1p \u1ee9ng c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh, cho \u0111\u1ebfn khi \u0111\u1ea1t li\u1ec1u \u0111i\u1ec1u tr\u1ecb hi\u1ec7u qu\u1ea3, th\u00f4ng th\u01b0\u1eddng l\u00e0 900- 1800 mg\/ng\u00e0y, chia 3 l\u1ea7n; t\u1ed1i \u0111a kh\u00f4ng qu\u00e1 2400 mg\/ ng\u00e0y.<\/p>\n<p>N\u00ean chia \u0111\u1ec1u t\u1ed5ng li\u1ec1u h\u00e0ng ng\u00e0y cho m\u1ed7i l\u1ea7n d\u00f9ng thu\u1ed1c v\u00e0 kho\u1ea3ng c\u00e1ch d\u00f9ng thu\u1ed1c kh\u00f4ng n\u00ean qu\u00e1 12 gi\u1edd. Khi d\u00f9ng li\u1ec1u cao c\u00f3 th\u1ec3 chia 4 l\u1ea7n\/ng\u00e0y.<\/p>\n<p>\u0110\u1ed1i v\u1edbi ng\u01b0\u1eddi b\u1ec7nh suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn v\u00e0 \u0111ang th\u1ea9m ph\u00e2m m\u00e1u ph\u1ea3i gi\u1ea3m li\u1ec1u; li\u1ec1u th\u00edch h\u1ee3p c\u1ea7n hi\u1ec7u ch\u1ec9nh theo \u0111\u1ed9 thanh th\u1ea3i creatinin, \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o nh\u01b0 sau:<\/p>\n<table>\n<tbody>\n<tr>\n<td><strong>\u0110\u1ed9 thanh th\u1ea3i creatinin (ml\/ph\u00fat)<\/strong><\/td>\n<td><strong>Li\u1ec1u d\u00f9ng<\/strong><\/td>\n<\/tr>\n<tr>\n<td>50 -70<\/td>\n<td>600 &#8211; 1200 mg\/ng\u00e0y, chia 3 l\u1ea7n<\/td>\n<\/tr>\n<tr>\n<td>30 \u2013 49<\/td>\n<td>300 &#8211; 600 mg\/ng\u00e0y, chia 3 l\u1ea7n<\/td>\n<\/tr>\n<tr>\n<td>15- 29<\/td>\n<td>300 mg (c\u00e1ch\u00a0 ng\u00e0y m\u1ed9t l\u1ea7n) &#8211; 300 mg\/ng\u00e0y, chia 3 l\u1ea7n<\/td>\n<\/tr>\n<tr>\n<td>&lt; 15<\/td>\n<td>300 mg c\u00e1ch ng\u00e0y m\u1ed9t ng\u00e0y m\u1ed9t l\u1ea7n, chia 3 l\u1ea7n<\/td>\n<\/tr>\n<tr>\n<td>Th\u1ea9m ph\u00e2n m\u00e1u<\/td>\n<td>200 &#8211; 300 mg *<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>*Li\u1ec1u n\u1ea1p l\u00e0 300 \u2013 400 mg cho ng\u01b0\u1eddi b\u1ec7nh l\u1ea7n \u0111\u1ea7u d\u00f9ng gabapentin, sau \u0111\u00f3 200 &#8211; 300 mg sau m\u1ed7i 4 gi\u1edd th\u1ea9m ph\u00e2n m\u00e1u.<\/p>\n<p>Tr\u1ebb em:<\/p>\n<p>Tr\u1ebb em t\u1eeb 6 \u0111\u1ebfn 12 tu\u1ed5i:<\/p>\n<p>Ng\u00e0y \u0111\u1ea7u ti\u00ean: 10 mg\/kg th\u1ec3 tr\u1ecdng, chia 3 l\u1ea7n.<\/p>\n<p>Ng\u00e0y th\u1ee9 hai: 20 mg\/ kg, chia 3 l\u1ea7n<\/p>\n<p>Ng\u00e0y th\u1ee9 3: 25 \u2013 35 mg\/kg, chia 3 l\u1ea7n<\/p>\n<p>Li\u1ec1u duy tr\u00ec l\u00e0 900 mg\/ ng\u00e0y v\u1edbi tr\u1ebb n\u1eb7ng t\u1eeb 26 \u2013 36 kg v\u00e0 1200 mg\/ng\u00e0y v\u1edbi tr\u1ebb n\u1eb7ng t\u1eeb 37 kg \u0111\u1ebfn 50 kg, t\u1ed5ng li\u1ec1u \/ ng\u00e0y \u0111\u01b0\u1ee3c chia u\u1ed1ng 3 l\u1ea7n.<\/p>\n<p>Tr\u1ebb 3 tu\u1ed5i \u0111\u1ebfn d\u01b0\u1edbi 6 tu\u1ed5i: Li\u1ec1u \u0111\u1ea7u 10 -15 mg\/kg\/ng\u00e0y, chia 3 l\u1ea7n; t\u0103ng li\u1ec1u l\u00ean trong 3 ng\u00e0y \u0111\u1ec3 \u0111\u1ea1t li\u1ec1u 25 -30 mg\/kg\/ng\u00e0y v\u1edbi tr\u1ebb 3 &#8211; 4 tu\u1ed5i ho\u1eb7c 25 &#8211; 30 mg\/ng\u00e0y v\u1edbi tr\u1ebb 5 tu\u1ed5i ho\u1eb7c h\u01a1n; t\u1ed5ng li\u1ec1u \/ ng\u00e0y \u0111\u01b0\u1ee3c chia u\u1ed1ng 3 l\u1ea7n.<\/p>\n<p>Ch\u01b0a c\u00f3 \u0111\u00e1nh gi\u00e1 v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng gabapentin cho tr\u1ebb em d\u01b0\u1edbi 12 tu\u1ed5i b\u1ecb suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn.<\/p>\n<p><em>\u0110i\u1ec1u tr\u1ecb \u0111au do vi\u00eam c\u00e1c d\u00e2y th\u1ea7n kinh ngo\u1ea1i bi\u00ean.\u0111au th\u1ea7n kinh:<\/em><\/p>\n<p>Ng\u01b0\u1eddi l\u1edbn: U\u1ed1ng kh\u00f4ng qu\u00e1 1800 mg\/ng\u00e0y, chia 3 l\u1ea7n. Ho\u1eb7c d\u00f9ng nh\u01b0 sau:<\/p>\n<p>Ng\u00e0y th\u1ee9 nh\u1ea5t: 300 mg.<\/p>\n<p>Ng\u00e0y th\u1ee9 2: 300 mg\/l\u1ea7n, ng\u00e0y 2 l\u1ea7n .<\/p>\n<p>Ng\u00e0y th\u1ee9 3: 300 mg\/l\u1ea7n, ng\u00e0y 3 l\u1ea7n.<\/p>\n<p>Sau \u0111\u00f3 li\u1ec1u c\u00f3 th\u1ec3 t\u0103ng th\u00eam t\u1eebng b\u01b0\u1edbc 300 mg m\u1ed7i ng\u00e0y, d\u1ef1a tr\u00ean \u0111\u00e1p \u1ee9ng c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh, cho \u0111\u1ebfn khi \u0111\u1ea1t li\u1ec1u t\u1ed1i \u0111a1800 mg\/ng\u00e0y, t\u1ed5ng li\u1ec1u\/ng\u00e0y \u0111\u01b0\u1ee3c chia u\u1ed1ng 3 l\u1ea7n.<\/p>\n<p>Ng\u01b0\u1eddi cao tu\u1ed5i: li\u1ec1u d\u00f9ng c\u00f3 th\u1ec3 th\u1ea5p do ch\u1ee9c n\u0103ng th\u1eadn k\u00e9m.<\/p>\n<p><strong>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh gabapentin \u1edf ng\u01b0\u1eddi M\u1eabn c\u1ea3m v\u1edbi gabapentin ho\u1eb7c b\u1ea5t c\u1ee9 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p><strong>4.4 Th\u1eadn tr\u1ecdng:<\/strong><\/p>\n<p>Kh\u00f4ng \u0111\u01b0\u1ee3c ng\u1eebng d\u00f9ng thu\u1ed1c \u0111\u1ed9t ng\u1ed9t c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh, v\u00ec c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m t\u0103ng d\u1ea7n t\u1ea7n s\u1ed1 co gi\u1eadt. B\u1ec7nh nh\u00e2n c\u1ea7n \u0111\u01b0\u1ee3c ch\u1ec9 d\u1eabn ch\u1ec9 \u0111\u01b0\u1ee3c d\u00f9ng gabapentin khi c\u00f3 \u0111\u01a1n k\u00ea c\u1ee7a th\u1ea7y thu\u1ed1c.<\/p>\n<p>B\u1ec7nh nh\u00e2n c\u1ea7n \u0111\u01b0\u1ee3c c\u1ea3nh b\u00e1o l\u00e0 gabapentin c\u00f3 th\u1ec3 g\u00e2y cho\u00e1ng v\u00e1ng, bu\u1ed3n ng\u1ee7 v\u00e0 c\u00e1c d\u1ea5u hi\u1ec7u tri\u1ec7u ch\u1ee9ng kh\u00e1c v\u1ec1 \u1ee9c ch\u1ebf h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng. V\u00ec v\u1eady, b\u1ec7nh nh\u00e2n kh\u00f4ng \u0111\u01b0\u1ee3c l\u00e1i xe ho\u1eb7c v\u1eadn h\u00e0nh m\u00e1y m\u00f3c ph\u1ee9c t\u1ea1p cho t\u1edbi khi th\u1ea5y r\u1eb1ng gabapentin \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 l\u00e0 kh\u00f4ng c\u00f3 h\u1ea1i g\u00ec t\u1edbi kh\u1ea3 n\u0103ng t\u00e2m th\u1ea7n v\u00e0 \/ ho\u1eb7c v\u1eadn \u0111\u1ed9ng.<\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>V\u00ec thu\u1ed1c g\u00e2y bu\u1ed3n ng\u1ee7, cho\u00e1ng v\u00e1ng, n\u00ean kh\u00f4ng v\u1eadn h\u00e0nh m\u00e1y m\u00f3c v\u00e0 l\u00e1i xe sau khi v\u1eeba d\u00f9ng thu\u1ed1c.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/strong><\/p>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: B1<\/p>\n<p>US FDA pregnancy category: C<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>Ch\u01b0a c\u00f3 c\u00e1c nghi\u00ean c\u1ee9u \u0111\u1ea7y \u0111\u1ee7 v\u00e0 c\u00f3 ki\u1ec3m so\u00e1t \u1edf ng\u01b0\u1eddi mang thai. V\u00ec nh\u1eefng nghi\u00ean c\u1ee9u v\u1ec1 s\u1ef1 sinh s\u1ea3n tr\u00ean s\u00fac v\u1eadt kh\u00f4ng ph\u1ea3i bao gi\u1edd c\u0169ng \u0111o\u00e1n tr\u01b0\u1edbc v\u1ec1 \u0111\u00e1p \u1ee9ng tr\u00ean ng\u01b0\u1eddi, n\u00ean ch\u1ec9 d\u00f9ng thu\u1ed1c n\u00e0y trong thai k\u1ef3 khi l\u1ee3i \u00edch cho m\u1eb9 v\u01b0\u1ee3t h\u1eb3n ti\u1ec1m n\u0103ng g\u00e2y nguy c\u01a1 cho thai.<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>Ch\u01b0a r\u00f5 s\u1ef1 b\u00e0i ti\u1ebft c\u1ee7a gabapentin qua s\u1eefa m\u1eb9. N\u00ean ch\u01b0a r\u00f5 \u1ea3nh h\u01b0\u1edfng t\u1edbi tr\u1ebb b\u00fa m\u1eb9. Tuy nhi\u00ean, v\u00ec nhi\u1ec1u thu\u1ed1c c\u00f3 th\u1ec3 b\u00e0i ti\u1ebft qua s\u1eefa ng\u01b0\u1eddi m\u1eb9, n\u00ean ch\u1ec9 d\u00f9ng gabapentin cho m\u1eb9 trong th\u1eddi k\u1ef3 cho con b\u00fa n\u1ebfu l\u1ee3i \u00edch cho m\u1eb9 v\u01b0\u1ee3t h\u1eb3n nguy c\u01a1.<\/p>\n<p><strong>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/strong><\/p>\n<p>C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 hay g\u1eb7p l\u00e0 bu\u1ed3n ng\u1ee7, cho\u00e1ng v\u00e1ng, m\u1ea5t \u0111i\u1ec1u ho\u00e0 v\u1eadn \u0111\u1ed9ng, m\u1ec7t m\u1ecfi v\u00e0 rung gi\u1eadt nh\u00e3n c\u1ea7u.<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<p><strong>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/strong><\/p>\n<p>M\u1ea5t ph\u1ed1i h\u1ee3p v\u1eadn \u0111\u1ed9ng th\u01b0\u1eddng li\u00ean quan \u0111\u1ebfn li\u1ec1u d\u00f9ng. N\u1ebfu gi\u1ea3m li\u1ec1u m\u00e0 kh\u00f4ng \u0111\u1ee1, ph\u1ea3i ng\u1eebng thu\u1ed1c.<\/p>\n<p>N\u1ebfu nghi ng\u1edd c\u00f3 h\u1ed9i ch\u1ee9ng Stevens-Johnson, ph\u1ea3i ng\u1eebng thu\u1ed1c. Kh\u00f4ng n\u00ean d\u1eebng thu\u1ed1c \u0111\u1ed9t ng\u1ed9t v\u00ec c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u1ea7n su\u1ea5t c\u00e1c c\u01a1n \u0111\u1ed9ng kinh. Tr\u01b0\u1edbc khi ng\u1eebng thu\u1ed1c ho\u1eb7c chuy\u1ec3n sang s\u1eed d\u1ee5ng thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh kh\u00e1c c\u1ea7n ph\u1ea3i gi\u1ea3m li\u1ec1u t\u1eeb t\u1eeb trong v\u00f2ng \u00edt nh\u1ea5t l\u00e0 7 ng\u00e0y.<\/p>\n<p><strong>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/strong><\/p>\n<p>Gabapentin kh\u00f4ng \u0111\u01b0\u1ee3c chuy\u1ec3n ho\u00e1 \u0111\u00e1ng k\u1ec3, c\u0169ng kh\u00f4ng c\u00f3 t\u01b0\u01a1ng t\u00e1c v\u1ec1 chuy\u1ec3n ho\u00e1 v\u1edbi c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh khi ph\u1ed1i h\u1ee3p th\u00f4ng th\u01b0\u1eddng.<\/p>\n<p>D\u1eef li\u1ec7u v\u1ec1 t\u01b0\u01a1ng t\u00e1c thu\u1ed1c m\u00f4 t\u1ea3 \u1edf d\u01b0\u1edbi \u0111\u00e2y l\u00e0 c\u00e1c nghi\u00ean c\u1ee9u \u0111\u1ea1t \u0111\u01b0\u1ee3c \u1edf ng\u01b0\u1eddi kho\u1ebb m\u1ea1nh v\u00e0 \u1edf b\u1ec7nh nh\u00e2n \u0111\u1ed9ng kinh:<\/p>\n<p>Phenytoin: Nghi\u00ean c\u1ee9u v\u1edbi li\u1ec1u \u0111\u01a1n v\u00e0 \u0111a gabapentin (m\u1ed7i l\u1ea7n 400 mg, ng\u00e0y 3 l\u1ea7n) \u1edf b\u1ec7nh nh\u00e2n \u0111\u1ed9ng kinh (n=8) d\u00f9ng \u0111\u01a1n tr\u1ecb li\u1ec7u phenytoin trong \u00edt nh\u1ea5t 2 th\u00e1ng, th\u1ea5y gabapentin kh\u00f4ng c\u00f3 \u1ea3nh h\u01b0\u1edfng t\u1edbi c\u00e1c n\u1ed3ng \u0111\u1ed9 \u0111\u00e1y c\u1ee7a phenytoin trong huy\u1ebft t\u01b0\u01a1ng \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh v\u00e0 phenytoin c\u0169ng kh\u00f4ng c\u00f3 \u00e1nh h\u01b0\u1edfng t\u1edbi d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a gabapentin.<\/p>\n<p>Carbamazepin: N\u1ed3ng \u0111\u1ed9 \u0111\u00e1y trong huy\u1ebft t\u01b0\u01a1ng khi \u1ed5n \u0111\u1ecbnh c\u1ee7a carbamazepin v\u00e0 carbamazepin 10,11 epoxid kh\u00f4hg b\u1ecb \u1ea3nh h\u01b0\u1edfng khi d\u00f9ng c\u00f9ng gabapentin (m\u1ed7i l\u1ea7n 400 mg, ng\u00e0y 3 l\u1ea7n; n=12). C\u0169ng v\u1eady, \u0111\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a gabapeni kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng khi ph\u1ed1i h\u1ee3p v\u1edbi carbamazepin.<\/p>\n<p>Acid valproic: C\u00e1c n\u1ed3ng \u0111\u1ed9 \u0111\u00e1y trung b\u00ecnh khi \u1ed5n \u0111\u1ecbnh trong huy\u1ebft thanh c\u1ee7a acid valproic tr\u01b0\u1edbc v\u00e0 trong khi d\u00f9ng c\u00f9ng gabapentin (m\u1ed7i l\u1ea7n 400 mg, ng\u00e0y 3 l\u1ea7n; n=12) kh\u00f4ng c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t v\u00e0 c\u00e1c th\u00f4ng s\u1ed1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a gabapentin c\u0169ng kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng khi d\u00f9ng c\u00f9ng acid valproic.<\/p>\n<p>Phenobarbital: C\u00e1c th\u00f4ng s\u1ed1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 \u1edf tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh v\u1edbi Phenobarbital ho\u1eb7c gabapentin (m\u1ed7i l\u1ea7n 300 mg, ng\u00e0y 3 l\u00e2n; n=12) l\u00e0 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng, d\u00f9 d\u00f9ng ri\u00eang r\u1ebd ho\u1eb7c ph\u1ed1i h\u1ee3p.<\/p>\n<p>Cimetidine: Khi c\u00f3 m\u1eb7t cimetidine (m\u1ed7i l\u1ea7n 300 mg, ng\u00e0y 4 l\u1ea7n; n=12), th\u1ea5y \u0111\u1ed9 thanh l\u1ecdc trung b\u00ecnh khi u\u1ed1ng gabapentin s\u1ebd gi\u1ea3m 14% v\u00e0 \u0111\u1ed9 thanh l\u1ecdc creatinin gi\u1ea3m 10%. Cimetidine c\u00f3 th\u1ec3 l\u00e0m \u1ea3nh h\u01b0\u1edbng x\u1ea5u \u0111\u1ebfn s\u1ef1 \u0111\u1ea3o th\u1ea3i qua th\u1eadn c\u1ee7a c\u1ea3 gabapentin v\u00e0 creatinin (l\u00e0 ch\u1ea5t \u0111\u00e1nh d\u1ea5u n\u1ed9i sinh c\u1ee7a ch\u1ee9c n\u0103ng th\u1eadn). S\u1ef1 gi\u1ea3m nh\u1eb9 \u0111\u00e0o th\u1ea3i c\u1ee7a gabapentin b\u1edfi cimetidine kh\u00f4ng c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng. Ch\u01b0a \u0111\u00e1nh gi\u00e1 \u0111\u01b0\u1ee3c \u1ea3nh h\u01b0\u1edfng c\u1ee7a gabapentin t\u1edbi cimetidine.<\/p>\n<p>Thu\u1ed1c u\u1ed1ng ng\u1eeba thai: D\u1ef1a v\u00e0o AUC v\u00e0 th\u1eddi gian b\u00e1n th\u1ea3i, d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc khi d\u00f9ng nhi\u1ec1u li\u1ec1u norethindrone v\u00e0 ethinyl estradiol sau khi u\u1ed1ng c\u00e1c vi\u00ean n\u00e9n ch\u1ee9a 2,5 mgnorethindrone acetat v\u00e0 50 microgamethinyl estradiol c\u0169ng t\u01b0\u01a1ng \u0111\u01b0\u01a1ng, d\u00f9 l\u00e0 d\u00f9ng c\u00f9ng ho\u1eb7c kh\u00f4ng c\u00f9ng gabapentin (m\u1ed7i l\u1ea7n 400 mg, ng\u00e0y 3 l\u1ea7n; n=13). Cmax c\u1ee7a norethindrone cao h\u01a1n 13% khi ph\u1ed1i h\u1ee3p v\u1edbi gabapentin, nh\u01b0ng t\u01b0\u01a1ng t\u00e1c n\u00e0y kh\u00f4ng c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng.<\/p>\n<p>Thu\u1ed1c kh\u00e1ng acid: Thu\u1ed1c kh\u00e1ng acid l\u00e0m gi\u1ea3m sinh kh\u1ea3 d\u1ee5ng c\u1ee7a gabapentin (n=16) kho\u1ea3ng 20%. S\u1ef1 gi\u1ea3m sinh kh\u1ea3 d\u1ee5ng s\u1ebd kho\u1ea3ng 5% khi d\u00f9ng gabapentin 2 gi\u1edd tr\u01b0\u1edbc khi u\u1ed1ng thu\u1ed1c kh\u00e1ng acid. Khuy\u1ebfn c\u00e1o c\u1ea7n u\u1ed1ng gabapentin \u00edt nh\u1ea5t 2 gi\u1edd tr\u01b0\u1edbc khi u\u1ed1ng thu\u1ed1c kh\u00e1ng acid.<\/p>\n<p>Probenecid: Probenecid l\u00e0 thu\u1ed1c phong b\u1ebf s\u1ef1 \u0111\u00e0o th\u1ea3i t\u00edch c\u1ef1c qua \u1ed1ng th\u1eadn. C\u00e1c th\u00f4ng s\u1ed1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a gabapentin \u0111\u1ec1u t\u01b0\u01a1ng t\u1ef1, d\u00f9 c\u00f3 hay kh\u00f4ng c\u00f3 ph\u1ed1i h\u1ee3p v\u1edbi probenecid. \u0110i\u1ec1u n\u00e0y cho th\u1ea5y gabapentin kh\u00f4ng \u0111\u00e0o th\u1ea3i t\u00edch c\u1ef1c qua \u1ed1ng th\u1eadn, l\u00e0 con \u0111\u01b0\u1eddng b\u1ecb \u1ee9c ch\u1ebf b\u1edfi probenecid.<\/p>\n<p><strong>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/strong><\/p>\n<p>Ch\u01b0a x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c li\u1ec1u ch\u1ebft c\u1ee7a gabapentin tr\u00ean chu\u1ed9t nh\u1eaft v\u00e0 chu\u1ed9t c\u1ed1ng cho u\u1ed1ng li\u1ec1u \u0111\u01a1n t\u1edbi 8000 mg\/kg c\u00e2n n\u1eb7ng. C\u00e1c d\u1ea5u hi\u1ec7u \u0111\u1ed9c t\u00ednh c\u1ea5p tr\u00ean s\u00fac v\u1eadt bao g\u1ed3m m\u1ea5t \u0111i\u1ec1u h\u00f2a v\u1eadn \u0111\u1ed9ng, kh\u00f3 th\u1edf, sa m\u00ed m\u1eaft, an th\u1ea7n, gi\u1ea3m ho\u1ea1t \u0111\u1ed9ng ho\u1eb7c k\u00edch th\u00edch;<\/p>\n<p>C\u00e1c li\u1ec1u c\u1ea5p t\u00ednh qu\u00e1 li\u1ec1u c\u1ee7a gabapentin t\u1edbi 49 gam \u0111\u00e3 g\u1eb7p \u1edf ng\u01b0\u1eddi. Trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p \u0111\u00f3, \u0111\u00e3 g\u1eb7p nh\u1eefng tri\u1ec7u ch\u1ee9ng nh\u01b0 nh\u00ecn \u0111\u00f4i, n\u00f3i l\u1eafp, ng\u1ee7 l\u01a1 m\u01a1, ng\u1ee7 l\u1ecbm, ti\u00eau ch\u1ea3y. M\u1ecdi b\u1ec7nh nh\u00e2n \u0111\u1ec1u h\u1ed3i ph\u1ee5c nh\u1edd \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3.<\/p>\n<p>C\u00f3 th\u1ec3 k\u00e9o gabapentin kh\u1ecfi c\u01a1 th\u1ec3 nh\u1edd th\u1ea9m t\u00e1ch l\u1ecdc m\u00e1u. M\u1eb7c d\u1ea7u th\u1ea9m t\u00e1ch l\u1ecdc m\u00e1u kh\u00f4ng \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh trong s\u1ed1 \u00edt tr\u01b0\u1eddng h\u1ee3p qu\u00e1 li\u1ec1u, c\u00f3 th\u1ec3 ch\u1ec9 \u0111\u1ecbnh t\u00f9y theo tr\u1ea1ng th\u00e1i l\u00e2m s\u00e0ng c\u1ee7a b\u1ec7nh nh\u00e2n ho\u1eb7c \u1edf b\u1ec7nh nh\u00e2n c\u00f3 suy th\u1eadn r\u00f5 r\u1ec7t.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/strong><\/p>\n<p><strong>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/strong><\/p>\n<p>Gabapentin l\u00e0 thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh, c\u01a1 ch\u1ebf hi\u1ec7n ch\u01b0a r\u00f5. Tr\u00ean s\u00fac v\u1eadt th\u1ef1c nghi\u1ec7m, thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng c\u01a1n du\u1ed7i c\u1ee9ng m\u1eb7t sau c\u00e1c chi khi l\u00e0m s\u1ed1c \u0111i\u1ec7n v\u00e0 c\u0169ng \u1ee9c ch\u1ebf \u0111\u01b0\u1ee3c c\u01a1n co gi\u1eadt do pentylentetrazol. C\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u1ee7a gabapentin t\u01b0\u01a1ng t\u1ef1 ch\u1ea5t \u1ee9c ch\u1ebf d\u1eabn truy\u1ec1n th\u1ea7n kinh l\u00e0 acid gama-aminobutyric (GABA), nh\u01b0ng gabapentin kh\u00f4ng t\u00e1c \u0111\u1ed9ng tr\u1ef1c ti\u1ebfp l\u00ean c\u00e1c th\u1ee5 th\u1ec3 GABA, kh\u00f4ng l\u00e0m thay \u0111\u1ed5i c\u1ea5u tr\u00fac, gi\u1ea3i ph\u00f3ng, chuy\u1ec3n h\u00f3a v\u00e0 thu h\u1ed3i GABA.<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>Gabapentin d\u1ec5 d\u00e0ng \u0111i v\u00e0o n\u00e3o v\u00e0 ng\u0103n ch\u1eb7n c\u01a1n co gi\u1eadt \u1edf m\u1ed9t s\u1ed1 m\u00f4 h\u00ecnh \u0111\u1ed9ng kinh tr\u00ean \u0111\u1ed9ng v\u1eadt. Gabapentin kh\u00f4ng c\u00f3 \u00e1i l\u1ef1c v\u1edbi c\u1ea3 th\u1ee5 th\u1ec3 GABAA v\u00e0 GABAB v\u00e0 c\u0169ng kh\u00f4ng l\u00e0m thay \u0111\u1ed5i s\u1ef1 chuy\u1ec3n h\u00f3a c\u1ee7a GABA. Gabapentin kh\u00f4ng g\u1eafn v\u1edbi c\u00e1c th\u1ee5 th\u1ec3 d\u1eabn truy\u1ec1n th\u1ea7n kinh kh\u00e1c trong n\u00e3o v\u00e0 kh\u00f4ng t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c k\u00eanh natri. Gabapentin g\u1eafn v\u1edbi \u00e1i l\u1ef1c cao v\u00e0o ti\u1ec3u \u0111\u01a1n v\u1ecb \u03b12\u03b4 (alpha-2-delta) c\u1ee7a c\u00e1c c\u1ed5ng d\u1eabn truy\u1ec1n \u0111i\u1ec7n th\u1ebf c\u1ee7a k\u00eanh calci v\u00e0 vi\u1ec7c gabapentin g\u1eafn v\u1edbi ti\u1ec3u \u0111\u01a1n v\u1ecb \u03b12\u03b4 \u0111\u01b0\u1ee3c cho l\u00e0 c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn t\u00e1c \u0111\u1ed9ng kh\u00e1ng co gi\u1eadt c\u1ee7a gabapentin \u1edf \u0111\u1ed9ng v\u1eadt. Vi\u1ec7c s\u00e0ng l\u1ecdc t\u1ea1i c\u1ed5ng d\u1eabn truy\u1ec1n kh\u00f4ng g\u1ee3i \u00fd \u0111\u00edch t\u00e1c d\u1ee5ng n\u00e0o kh\u00e1c c\u1ee7a thu\u1ed1c ngo\u00e0i \u03b12\u03b4.<\/p>\n<p>B\u1eb1ng ch\u1ee9ng t\u1eeb nhi\u1ec1u m\u00f4 h\u00ecnh ti\u1ec1n l\u00e2m s\u00e0ng cho th\u1ea5y t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd c\u1ee7a gabapentin c\u00f3 th\u1ec3 l\u00e0 do vi\u1ec7c g\u1eafn v\u1edbi th\u1ee5 th\u1ec3 \u03b12\u03b4, do \u0111\u00f3 l\u00e0m gi\u1ea3m gi\u1ea3i ph\u00f3ng c\u00e1c ch\u1ea5t d\u1eabn truy\u1ec1n th\u1ea7n kinh k\u00edch th\u00edch trong c\u00e1c v\u00f9ng thu\u1ed9c h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng. \u0110i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 l\u00e0 nguy\u00ean nh\u00e2n \u0111\u1eabn \u0111\u1ebfn t\u00e1c d\u1ee5ng kh\u00e1ng co gi\u1eadt c\u1ee7a gabapentin. S\u1ef1 li\u00ean quan gi\u1eefa ho\u1ea1t t\u00ednh c\u1ee7a gabapentin v\u1edbi t\u00e1c d\u1ee5ng ch\u1ed1ng co gi\u1eadt tr\u00ean ng\u01b0\u1eddi v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp.<\/p>\n<p>Gabapentin c\u0169ng cho th\u1ea5y hi\u1ec7u qu\u1ea3 trong nhi\u1ec1u m\u00f4 h\u00ecnh \u0111au ti\u1ec1n l\u00e2m s\u00e0ng \u1edf \u0111\u1ed9ng v\u1eadt. Vi\u1ec7c g\u1eafn \u0111\u1eb7c hi\u1ec7u gabapentin v\u00e0o ti\u1ec3u \u0111\u01a1n v\u1ecb \u03b12\u03b4 \u0111\u01b0\u1ee3c cho r\u1eb1ng s\u1ebd d\u1eabn \u0111\u1ebfn nhi\u1ec1u ho\u1ea1t \u0111\u1ed9ng kh\u00e1c bi\u1ec7t m\u00e0 c\u00e1c ho\u1ea1t \u0111\u1ed9ng n\u00e0y c\u00f3 th\u1ec3 l\u00e0 nguy\u00ean nh\u00e2n c\u1ee7a vi\u1ec7c gi\u1ea3m \u0111au trong m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt. T\u00e1c d\u1ee5ng gi\u1ea3m \u0111au c\u1ee7a gabapentin c\u00f3 th\u1ec3 \u1edf tr\u00ean t\u1ee7y s\u1ed1ng c\u0169ng nh\u01b0 trong c\u00e1c trung t\u00e2m n\u00e3o cao h\u01a1n th\u00f4ng qua vi\u1ec7c t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c con \u0111\u01b0\u1eddng \u1ee9c ch\u1ebf \u0111au h\u01b0\u1edbng xu\u1ed1ng. S\u1ef1 li\u00ean quan c\u1ee7a c\u00e1c t\u00ednh ch\u1ea5t ti\u1ec1n l\u00e2m s\u00e0ng n\u00e0y v\u1edbi t\u00e1c \u0111\u1ed9ng l\u00e2m s\u00e0ng tr\u00ean ng\u01b0\u1eddi v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c bi\u1ebft.<\/p>\n<p><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/p>\n<p><strong>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/strong><\/p>\n<p><em>H\u1ea5p thu:<\/em> Sinh kh\u1ea3 d\u1ee5ng c\u1ee7a gabapentin kh\u00f4ng t\u1ef7 l\u1ec7 thu\u1eadn v\u1edbi li\u1ec1u l\u01b0\u1ee3ng, nh\u01b0ng t\u0103ng li\u1ec1u th\u00ec sinh kh\u1ea3 d\u1ee5ng s\u1ebd gi\u1ea3m. V\u1edbi li\u1ec1u 400 mg, sinh kh\u1ea3 d\u1ee5ng s\u1ebd k\u00e9m 25% so v\u1edbi li\u1ec1u 100 mg. Tuy nhi\u00ean v\u1edbi kho\u1ea3ng li\u1ec7u 300-600 mg, ng\u00e0y 3 l\u1ea7n, th\u00ec nh\u1eefng kh\u00e1c bi\u1ec7t v\u1ec1 sinh kh\u1ea3 d\u1ee5ng kh\u00f4ng qu\u00e1 r\u00f5, v\u00e0 sinh kh\u1ea3 d\u1ee5ng l\u00e0 kho\u1ea3ng 60%. Th\u1ee9c \u0103n kh\u00f4ng c\u00f3 \u1ea3nh h\u01b0\u1edfng t\u1edbi t\u1ed1c \u0111\u1ed9 v\u00e0 m\u1ee9c \u0111\u1ed9 c\u1ee7a s\u1ef1 h\u1ea5p th\u1ee5 gabapentin.<\/p>\n<p><em>Ph\u00e2n b\u1ed1<\/em>: Gabapentin l\u01b0u th\u00f4ng trong tu\u1ea7n ho\u00e0n v\u00e0 r\u1ea5t \u00edt g\u1eafn v\u00e0o protein huy\u1ebft t\u01b0\u01a1ng (&lt;3%). V\u1edbi b\u1ec7nh nh\u00e2n \u0111\u1ed9ng kinh, c\u00e1c n\u1ed3ng \u0111\u1ed9 \u0111\u00e1y (Cmin) c\u1ee7a gabapentin trong d\u1ecbch n\u00e3o t\u1ee7y l\u00e0 kho\u1ea3ng 20% so v\u1edbi n\u1ed3ng \u0111\u1ed9 \u0111\u00e1y t\u01b0\u01a1ng \u1ee9ng \u1edf huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<p><em>Chuy\u1ec3n h\u00f3a:<\/em> Gabapentin kh\u00f4ng chuy\u1ec3n h\u00f3a \u0111\u00e1ng k\u1ec3 \u1edf ng\u01b0\u1eddi.<\/p>\n<p><em>\u0110\u00e0o th\u1ea3i:<\/em> Gabapentin b\u1ecb th\u1ea3i kh\u1ecfi tu\u1ea7n ho\u00e0n d\u01b0\u1edbi d\u1ea1ng ch\u01b0a chuy\u1ec3n h\u00f3a v\u00e0 qua th\u1eadn.<\/p>\n<p><strong>5.3 Gi\u1ea3i th\u00edch: <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong>5.4 Thay th\u1ebf thu\u1ed1c : <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/strong><\/p>\n<p><strong>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/strong><\/p>\n<p><strong>6.2. T\u01b0\u01a1ng k\u1ef5 :<\/strong><\/p>\n<p>Kh\u00f4ng \u00e1p d\u1ee5ng.<\/p>\n<p><strong>6.3. B\u1ea3o qu\u1ea3n: <\/strong><\/p>\n<p>Nang v\u00e0 vi\u00ean n\u00e9n: B\u1ea3o qu\u1ea3n \u1edf nhi\u1ec7t \u0111\u1ed9 t\u1eeb 15 &#8211; 30 <sup>o<\/sup>C.<\/p>\n<p><strong>6.4. Th\u00f4ng tin kh\u00e1c :<\/strong><\/p>\n<p>Kh\u00f4ng c\u00f3.<\/p>\n<p><strong>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/strong><\/p>\n<p>D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n<p>Ho\u1eb7c HDSD Thu\u1ed1c.<\/p>\n<p><strong>7. Ng\u01b0\u1eddi \u0111\u0103ng t\u1ea3i \/T\u00e1c gi\u1ea3:<\/strong><\/p>\n<p>B\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c s\u01b0u t\u1ea7m ho\u1eb7c vi\u1ebft b\u1edfi: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-tac-gia-bac-sy-do-my-linh\/\">B\u00e1c s\u0129 nhi khoa &#8211; \u0110\u1ed7 M\u1ef9 Linh.<\/a><\/p>\n<p>Ki\u1ec3m duy\u1ec7t , hi\u1ec7u \u0111\u00ednh v\u00e0 \u0111\u0103ng t\u1ea3i: <a href=\"https:\/\/pharmog.com\/wp\/thong-tin-ve-pharmog-team\/\">PHARMOG TEAM<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Thu\u1ed1c Gabalept , Microleptin l\u00e0 thu\u1ed1c g\u00ec ? D\u01b0\u1edbi \u0111\u00e2y l\u00e0 n\u1ed9i dung t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng g\u1ed1c c\u1ee7a Thu\u1ed1c Gabalept , Microleptin (Th\u00f4ng tin bao g\u1ed3m li\u1ec1u d\u00f9ng, c\u00e1ch d\u00f9ng, ch\u1ec9 \u0111\u1ecbnh, ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, th\u1eadn tr\u1ecdng, d\u01b0\u1ee3c l\u00fd&#8230;) 1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Gabapentin Ph\u00e2n lo\u1ea1i: Thu\u1ed1c [&hellip;]<\/p>\n","protected":false},"author":8612,"featured_media":27035,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[926],"class_list":["post-27034","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-gabapentin"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/27034","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/8612"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=27034"}],"version-history":[{"count":3,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/27034\/revisions"}],"predecessor-version":[{"id":47122,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/27034\/revisions\/47122"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/27035"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=27034"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=27034"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=27034"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}