{"id":2492,"date":"2018-11-15T16:59:53","date_gmt":"2018-11-15T09:59:53","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=2492"},"modified":"2025-01-08T22:05:59","modified_gmt":"2025-01-08T15:05:59","slug":"zoledronic-acid","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/zoledronic-acid\/","title":{"rendered":"Zoledronic acid"},"content":{"rendered":"

1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: <\/strong><\/p>\n

Ho\u1ea1t ch\u1ea5t :<\/em> Zoledronic acid<\/strong><\/p>\n

Ph\u00e2n lo\u1ea1i: <\/em><\/strong>Thu\u1ed1c \u1ee9c ch\u1ebf ti\u00eau x\u01b0\u01a1ng, \u0111i\u1ec1u tr\u1ecb lo\u00e3ng x\u01b0\u01a1ng nh\u00f3m Bisphosphonates.<\/em><\/p>\n

Nh\u00f3m<\/em><\/strong> ph\u00e1p l\u00fd: <\/em><\/strong>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n

M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): M05BA08.<\/p>\n

Brand name:<\/em><\/strong> Aclasta<\/a>, Zometa<\/a>.<\/p>\n

Generic <\/em><\/strong>: Zoledronic acid, Acido Zoledronico Richet,DIGAFIL 4MG\/5ML,DIGAFIL 5MG\/100ML, Esmo, Leuzotev,RIBOMETA,Simpla,Sinresor,Sunzobone,Zemitron,Zogenex,Zolasta,Accord Zoledronic Acid, Zoldal, Zoldria,Zoledronic acid Actavis 4mg\/5ml<\/a>,Zoledronic acid for injection 4mg,Zoledronic Acid Hospira 4mg\/5ml, Zoledronic acid-hameln 4mg\/5ml solution for infusion,Zolenate,Zolex 4mg,Zomekal.<\/p>\n

2. D\u1ea1ng b\u00e0o ch\u1ebf – H\u00e0m l\u01b0\u1ee3ng: <\/strong><\/p>\n

D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n

L\u1ecd 4 mg\/5 ml \u0111\u1ec3 pha truy\u1ec1n t\u0129nh m\u1ea1ch; 5 mg\/100 ml.<\/p>\n

Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n\n\n\n\n\n\n
SINRESOR<\/em><\/strong><\/td>\n<\/td>\n<\/tr>\n
M\u1ed7i l\u1ecd 5ml c\u00f3 ch\u1ee9a:<\/em><\/td>\n<\/td>\n<\/tr>\n
Zoledronic acid<\/td>\n………………………….<\/td>\n4 mg<\/td>\n<\/tr>\n
T\u00e1 d\u01b0\u1ee3c<\/td>\n………………………….<\/td>\nv\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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3. Video by Pharmog:<\/strong><\/p>\n

[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n

————————————————<\/p>\n

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4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng: <\/strong><\/p>\n

4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n

\u0110i\u1ec1u tr\u1ecb t\u0103ng calci m\u00e1u do kh\u1ed1i u \u00e1c t\u00ednh.<\/p>\n

Di c\u0103n x\u01b0\u01a1ng do ung th\u01b0 hay t\u1ed5n th\u01b0\u01a1ng x\u01b0\u01a1ng do b\u1ec7nh \u0111a u t\u1ee7y x\u01b0\u01a1ng.<\/p>\n

B\u1ec7nh Paget x\u01b0\u01a1ng.<\/p>\n

Ph\u00f2ng v\u00e0 \u0111i\u1ec1u tr\u1ecb lo\u00e3ng x\u01b0\u01a1ng (\u1edf ph\u1ee5 n\u1eef sau m\u00e3n kinh, nam gi\u1edbi l\u1edbn tu\u1ed5i, lo\u00e3ng x\u01b0\u01a1ng do s\u1eed d\u1ee5ng corticoid).<\/p>\n

4.2. Li\u1ec1u d\u00f9ng – C\u00e1ch d\u00f9ng:<\/strong><\/p>\n

C\u00e1ch d\u00f9ng<\/em><\/strong> : D\u00f9ng pha truy\u1ec1n t\u0129nh m\u1ea1ch.<\/p>\n

Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n

T\u0103ng calci m\u00e1u do kh\u1ed1i u \u00e1c t\u00ednh:<\/em><\/p>\n

D\u00f9ng m\u1ed9t li\u1ec1u \u0111\u01a1n 4 mg, h\u00f2a tan trong 100 ml dung d\u1ecbch natri clorid 0,9% ho\u1eb7c glucose 5%, truy\u1ec1n t\u0129nh m\u1ea1ch trong \u00edt nh\u1ea5t 15 ph\u00fat, c\u00f3 th\u1ec3 l\u1eb7p l\u1ea1i sau \u00edt nh\u1ea5t 7 ng\u00e0y (n\u1ebfu th\u1ea5y c\u1ea7n thi\u1ebft) c\u0169ng v\u1edbi li\u1ec1u tr\u00ean. M\u1ed7i l\u1ea7n d\u00f9ng kh\u00f4ng n\u00ean qu\u00e1 4 mg v\u00ec s\u1ebd l\u00e0m t\u0103ng nguy c\u01a1 t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n tr\u00ean th\u1eadn.<\/p>\n

Di c\u0103n x\u01b0\u01a1ng do ung th\u01b0:<\/em> M\u1ed9t li\u1ec1u \u0111\u01a1n 4 mg, ph\u1ea3i pha lo\u00e3ng nh\u01b0 tr\u00ean, truy\u1ec1n t\u0129nh m\u1ea1ch 3 – 4 tu\u1ea7n m\u1ed9t l\u1ea7n.<\/p>\n

\u0110au t\u1ee7y x\u01b0\u01a1ng:<\/em> 4 mg, truy\u1ec1n t\u0129nh m\u1ea1ch kh\u00f4ng d\u01b0\u1edbi 15 ph\u00fat, c\u00e1ch 3 – 4 tu\u1ea7n\/l\u1ea7n. B\u1ed5 sung calci 500 mg (u\u1ed1ng) v\u00e0 polyvitamin ch\u1ee9a 400 \u0111vqt Vitamin D.<\/p>\n

B\u1ec7nh Paget x\u01b0\u01a1ng:<\/em> Truy\u1ec1n t\u0129nh m\u1ea1ch m\u1ed9t li\u1ec1u \u0111\u01a1n 5 mg. \u0110\u1ec3 l\u00e0m gi\u1ea3m nguy c\u01a1 gi\u1ea3m calci m\u00e1u do acid zoledronic, m\u1ed7i b\u1ec7nh nh\u00e2n ph\u1ea3i \u0111\u01b0\u1ee3c b\u1ed5 sung 1,5 g calci\/ng\u00e0y (750 mg, 2 l\u1ea7n\/ng\u00e0y ho\u1eb7c 500 mg, 3 l\u1ea7n\/ng\u00e0y) v\u00e0 800 \u0111vqt Vitamin D\/ng\u00e0y, \u0111\u1eb7c bi\u1ec7t trong 2 tu\u1ea7n \u0111\u1ea7u ti\u00ean sau khi d\u00f9ng acid zoledronic.<\/p>\n

\u0110i\u1ec1u tr\u1ecb lo\u00e3ng x\u01b0\u01a1ng (sau m\u00e3n kinh, do corticoid):<\/em> m\u1ed9t li\u1ec1u \u0111\u01a1n 5 mg, truy\u1ec1n t\u0129nh m\u1ea1ch 1 l\u1ea7n\/1 n\u0103m.<\/p>\n

D\u1ef1 ph\u00f2ng lo\u00e3ng x\u01b0\u01a1ng sau m\u00e3n kinh:<\/em> 5 mg, truy\u1ec1n t\u0129nh m\u1ea1ch kh\u00f4ng d\u01b0\u1edbi 15 ph\u00fat, c\u00e1ch 2 n\u0103m\/l\u1ea7n.<\/p>\n

\u0110i\u1ec1u ch\u1ec9nh li\u1ec1u tr\u00ean b\u1ec7nh nh\u00e2n suy th\u1eadn:<\/em><\/p>\n

Cl > 60 ml\/ph\u00fat: 4 mg (kh\u00f4ng c\u1ea7n ch\u1ec9nh li\u1ec1u).<\/p>\n

Cl 50 – 60 ml\/ph\u00fat: 3,5 mg.<\/p>\n

Cl 40 – 49 ml\/ph\u00fat: 3,3 mg.<\/p>\n

Cl 30 – 39 ml\/ph\u00fat: 3 mg.<\/p>\n

Cl < 30 ml\/ph\u00fat: Kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng.<\/p>\n

4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n

M\u1eabn c\u1ea3m v\u1edbi acid zoledronic, ho\u1eb7c c\u00e1c bisphosphonat kh\u00e1c, ho\u1eb7c m\u1eabn c\u1ea3m v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n

Gi\u1ea3m calci m\u00e1u.<\/p>\n

Ph\u1ee5 n\u1eef mang thai, cho con b\u00fa.<\/p>\n

Cl < 30 ml\/ph\u00fat, ho\u1eb7c b\u1ec7nh nh\u00e2n c\u00f3 suy th\u1eadn c\u1ea5p.<\/p>\n

Kh\u00f4ng d\u00f9ng khi b\u1ec7nh nh\u00e2n \u0111ang \u0111i\u1ec1u tr\u1ecb b\u1eb1ng m\u1ed9t bisphosphonat kh\u00e1c.<\/p>\n

4.4 Th\u1eadn tr\u1ecdng:<\/strong><\/p>\n

Tr\u01b0\u1edbc v\u00e0 sau khi d\u00f9ng acid zoledronic, ph\u1ea3i b\u1ea3o \u0111\u1ea3m c\u01a1 th\u1ec3 c\u00f3 \u0111\u1ee7 n\u01b0\u1edbc v\u00ec thi\u1ebfu n\u01b0\u1edbc trong c\u01a1 th\u1ec3 d\u1ec5 l\u00e0m t\u1ed5n th\u01b0\u01a1ng th\u1eadn.<\/p>\n

Acid zoledronic \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn calci nhi\u1ec1u h\u01a1n c\u00e1c bisphosphonat kh\u00e1c, do \u0111\u00f3 c\u00f3 th\u1ec3 g\u00e2y gi\u1ea3m calci n\u1eb7ng d\u1eabn \u0111\u1ebfn tetany hay d\u1ecb c\u1ea3m. C\u1ea7n \u0111i\u1ec1u tr\u1ecb t\u00ecnh tr\u1ea1ng gi\u1ea3m calci m\u00e1u v\u00e0 \u0111i\u1ec1u ch\u1ec9nh c\u00e1c y\u1ebfu t\u1ed1 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn chuy\u1ec3n h\u00f3a x\u01b0\u01a1ng ho\u1eb7c mu\u1ed1i kho\u00e1ng (nh\u01b0 suy tuy\u1ebfn c\u1eadn gi\u00e1p, ph\u1eabu thu\u1eadt tuy\u1ebfn gi\u00e1p, ph\u1eabu thu\u1eadt tuy\u1ebfn c\u1eadn gi\u00e1p, r\u1ed1i lo\u1ea1n h\u1ea5p thu, c\u1eaft \u0111o\u1ea1n ru\u1ed9t non…) tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u li\u1ec7u ph\u00e1p acid zoledronic \u0111\u1ed1i v\u1edbi b\u1ec7nh Paget x\u01b0\u01a1ng, lo\u00e3ng x\u01b0\u01a1ng \u1edf ph\u1ee5 n\u1eef m\u00e3n kinh v\u00e0 c\u1ea3 b\u1ec7nh t\u0103ng calci m\u00e1u do kh\u1ed1i u \u00e1c t\u00ednh. C\u1ea7n ki\u1ec3m so\u00e1t n\u1ed3ng \u0111\u1ed9 c\u00e1c ch\u1ea5t \u0111i\u1ec7n gi\u1ea3i, calci, phosphat v\u00e0 magnesi m\u00e1u tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y. N\u1ebfu c\u00f3 gi\u1ea3m n\u1ed3ng \u0111\u1ed9 c\u00e1c ch\u1ea5t tr\u00ean, c\u1ea7n b\u1ed5 sung tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng acid zoledronic. Thi\u1ebfu h\u1ee5t vitamin D ph\u1ea3i \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u cho acid zoledronic.<\/p>\n

C\u00e1c bisphosphonat c\u00f3 th\u1ec3 g\u00e2y ho\u1ea1i t\u1eed x\u01b0\u01a1ng h\u00e0m, \u0111\u1eb7c bi\u1ec7t tr\u00ean b\u1ec7nh nh\u00e2n ung th\u01b0. Tuy nhi\u00ean, lo\u00e3ng x\u01b0\u01a1ng \u1edf ph\u1ee5 n\u1eef m\u00e3n kinh hay c\u00e1c b\u1ec7nh l\u00fd kh\u00e1c c\u0169ng c\u00f3 th\u1ec3 g\u1eb7p. C\u1ea7n kh\u00e1m r\u0103ng v\u00e0 c\u00f3 k\u1ebf ho\u1ea1ch ph\u00f2ng ng\u1eeba v\u1ec1 r\u0103ng tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng acid zoledronic, \u0111\u1eb7c bi\u1ec7t tr\u00ean b\u1ec7nh nh\u00e2n c\u00f3 y\u1ebfu t\u1ed1 nguy c\u01a1 (nh\u01b0 b\u1ec7nh nh\u00e2n ung th\u01b0, \u0111ang d\u00f9ng h\u00f3a tr\u1ecb li\u1ec7u, tia x\u1ea1, corticoid, v\u1ec7 sinh r\u0103ng mi\u1ec7ng k\u00e9m). Tr\u00e1nh c\u00e1c th\u1ee7 thu\u1eadt x\u00e2m l\u1ea5n \u1edf r\u0103ng trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb b\u1eb1ng acid zoledronic.<\/p>\n

M\u1eb7c d\u00f9 kh\u00f4ng th\u01b0\u1eddng xuy\u00ean, song c\u00e1c bi\u1ec3u hi\u1ec7n \u0111au x\u01b0\u01a1ng nghi\u00eam tr\u1ecdng (c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn y\u1ebfu x\u01b0\u01a1ng), \u0111au c\u01a1 v\u00e0 \u0111au kh\u1edbp c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb b\u1eb1ng bisphosphonat. Tri\u1ec7u ch\u1ee9ng \u0111au c\u00f3 th\u1ec3 k\u00e9o d\u00e0i t\u1eeb 1 ng\u00e0y \u0111\u1ebfn v\u00e0i th\u00e1ng v\u00e0 s\u1ebd h\u1ebft khi ng\u1eebng \u0111i\u1ec1u tr\u1ecb. B\u1ec7nh nh\u00e2n khi g\u1eb7p c\u00e1c tri\u1ec7u ch\u1ee9ng n\u00e0y c\u1ea7n b\u00e1o cho b\u00e1c s\u0129 bi\u1ebft. Kh\u00f4ng n\u00ean d\u00f9ng cho b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed \u0111au t\u01b0\u01a1ng t\u1ef1 khi \u0111\u00e3 \u0111i\u1ec1u tr\u1ecb b\u1eb1ng m\u1ed9t bisphosphonat kh\u00e1c.<\/p>\n

Th\u1eadn tr\u1ecdng trong tr\u01b0\u1eddng h\u1ee3p suy gan n\u1eb7ng.<\/p>\n

C\u00e1c bisphosphonat c\u00f3 th\u1ec3 g\u00e2y co th\u1eaft kh\u00ed qu\u1ea3n \u1edf b\u1ec7nh nh\u00e2n hen nh\u1ea1y c\u1ea3m v\u1edbi aspirin, c\u1ea7n d\u00f9ng th\u1eadn tr\u1ecdng acid zoledronic \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y.<\/p>\n

T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n

C\u1ea7n th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng cho c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n

4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/strong><\/p>\n

X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n

AU TGA pregnancy category: B3<\/p>\n

US FDA pregnancy category: D<\/p>\n

Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n

M\u1eb7c d\u00f9 ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u tr\u00ean ng\u01b0\u1eddi v\u1ec1 nguy c\u01a1 \u0111\u1ed1i v\u1edbi thai khi m\u1eb9 s\u1eed d\u1ee5ng thu\u1ed1c trong th\u1eddi k\u1ef3 mang thai, song nh\u1eefng nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y c\u00e1c bisphosphonat v\u00e0o x\u01b0\u01a1ng thai nhi nhi\u1ec1u h\u01a1n v\u00e0o x\u01b0\u01a1ng c\u1ee7a m\u1eb9, do \u0111\u00f3 c\u00f3 gi\u1ea3 thuy\u1ebft cho r\u1eb1ng nguy c\u01a1 g\u00e2y h\u1ea1i cho thai (nh\u01b0 b\u1ea5t th\u01b0\u1eddng h\u1ec7 x\u01b0\u01a1ng ho\u1eb7c c\u00e1c b\u1ea5t th\u01b0\u1eddng kh\u00e1c) c\u00f3 th\u1ec3 x\u1ea3y ra ngay c\u1ea3 khi ng\u01b0\u1eddi m\u1eb9 c\u00f3 thai sau khi \u0111\u00e3 ho\u00e0n t\u1ea5t li\u1ec7u tr\u00ecnh \u0111i\u1ec1u tr\u1ecb b\u1eb1ng bisphosphonat. Nh\u1eefng y\u1ebfu t\u1ed1 \u1ea3nh h\u01b0\u1edfng t\u1edbi s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a thai nh\u01b0: Th\u1eddi gian t\u1eeb khi ng\u1eebng bisphosphonat \u0111\u1ebfn khi th\u1ee5 thai, lo\u1ea1i bisphosphonat \u0111\u01b0\u1ee3c d\u00f9ng v\u00e0 \u0111\u01b0\u1eddng d\u00f9ng bisphosphonat c\u00f2n \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u. Do v\u1eady, kh\u00f4ng n\u00ean d\u00f9ng acid zoledronic cho ph\u1ee5 n\u1eef c\u00f3 thai. V\u1edbi ph\u1ee5 n\u1eef \u0111ang trong \u0111\u1ed9 tu\u1ed5i sinh \u0111\u1ebb, n\u00ean d\u00f9ng thu\u1ed1c tr\u00e1nh thai trong khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng acid zoledronic.<\/p>\n

Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n

Kh\u00f4ng bi\u1ebft acid zoledronic c\u00f3 qua s\u1eefa m\u1eb9 hay kh\u00f4ng, h\u01a1n n\u1eefa, acid zoledronic \u0111\u01b0\u1ee3c l\u01b0u gi\u1eef \u1edf x\u01b0\u01a1ng trong m\u1ed9t th\u1eddi gian d\u00e0i n\u00ean kh\u00f4ng d\u00f9ng cho ph\u1ee5 n\u1eef cho con b\u00fa.<\/p>\n

4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/strong><\/p>\n

Th\u01b0\u1eddng g\u1eb7p, ADR > 1\/100<\/em><\/p>\n

Gi\u1ea3m phosphat m\u00e1u, thi\u1ebfu m\u00e1u, h\u1ed9i ch\u1ee9ng gi\u1ea3 c\u00fam (\u0111au x\u01b0\u01a1ng, \u0111au c\u01a1, \u0111au kh\u1edbp, s\u1ed1t, c\u1ee9ng c\u01a1), r\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a, rung nh\u0129, \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, vi\u00eam k\u1ebft m\u1ea1c, suy th\u1eadn (hi\u1ebfm khi suy th\u1eadn c\u1ea5p).<\/p>\n

\u00cdt g\u1eb7p,1\/1000 < ADR < 1\/100<\/em><\/p>\n

Ch\u00e1n \u0103n, r\u1ed1i lo\u1ea1n v\u1ecb gi\u00e1c, kh\u00f4 mi\u1ec7ng, vi\u00eam mi\u1ec7ng, \u0111au ng\u1ef1c, t\u0103ng huy\u1ebft \u00e1p, gi\u1ea3m huy\u1ebft \u00e1p, kh\u00f3 th\u1edf, ho, thay \u0111\u1ed5i c\u1ea3m gi\u00e1c, run c\u01a1, lo l\u1eafng, r\u1ed1i lo\u1ea1n gi\u1ea5c ng\u1ee7, nh\u00ecn m\u1edd, t\u0103ng c\u00e2n, ng\u1ee9a, ban \u0111\u1ecf, \u0111\u1ed5 m\u1ed3 h\u00f4i, chu\u1ed9t r\u00fat, huy\u1ebft ni\u1ec7u, protein ni\u1ec7u, ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn (bao g\u1ed3m ph\u00f9 m\u1ea1ch), suy nh\u01b0\u1ee3c, ph\u00f9 ngo\u1ea1i vi, gi\u1ea3m ti\u1ec3u c\u1ea7u, gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m magnesi huy\u1ebft, gi\u1ea3m kali huy\u1ebft, ph\u1ea3n \u1ee9ng t\u1ea1i ch\u1ed7 ti\u00eam<\/p>\n

Hi\u1ebfm g\u1eb7p, ADR < 1\/1000<\/em><\/p>\n

Ch\u1eadm nh\u1ecbp tim, l\u00fa l\u1eabn, t\u0103ng K+, t\u0103ng Na+ m\u00e1u, gi\u1ea3m to\u00e0n th\u1ec3 huy\u1ebft c\u1ea7u, ho\u1ea1i t\u1eed x\u01b0\u01a1ng h\u00e0m, g\u00e3y x\u01b0\u01a1ng \u0111\u00f9i kh\u00f4ng \u0111i\u1ec3n h\u00ecnh, vi\u00eam m\u00e0ng m\u1ea1ch v\u00e0 vi\u00eam c\u1ee7ng m\u1ea1c.<\/p>\n

Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n

4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/strong><\/p>\n

Gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd n\u1ed3ng \u0111\u1ed9 calci, phosphat v\u00e0 magnesi m\u00e1u tr\u01b0\u1edbc v\u00e0 trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb b\u1eb1ng acid zoledronic. B\u1ed5 sung calci v\u00e0 vitamin D l\u00e0 r\u1ea5t quan tr\u1ecdng \u0111\u1ec3 duy tr\u00ec n\u1ed3ng \u0111\u1ed9 calci m\u00e1u \u1edf b\u1ec7nh nh\u00e2n Paget x\u01b0\u01a1ng, \u0111a u t\u1ee7y, c\u00e1c kh\u1ed1i u di c\u0103n t\u1edbi x\u01b0\u01a1ng v\u00e0 c\u1ea3 b\u1ec7nh lo\u00e3ng x\u01b0\u01a1ng. Khuy\u00ean b\u1ec7nh nh\u00e2n n\u00ean b\u00e1o cho b\u00e1c s\u0129 ngay khi c\u00f3 c\u00e1c d\u1ea5u hi\u1ec7u c\u1ee7a gi\u1ea3m calci m\u00e1u nh\u01b0: c\u1ea3m gi\u00e1c t\u00ea ho\u1eb7c \u0111au nh\u00f3i d\u00e2y th\u1ea7n kinh (\u0111\u1eb7c bi\u1ec7t trong ho\u1eb7c quanh mi\u1ec7ng) ho\u1eb7c co gi\u1eadt c\u01a1 xu\u1ea5t hi\u1ec7n. Suy th\u1eadn c\u00f3 th\u1ec3 g\u1eb7p trong khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng acid zoledronic, do \u0111\u00f3 c\u1ea7n \u0111\u00e1nh gi\u00e1 ch\u1ee9c n\u0103ng th\u1eadn tr\u01b0\u1edbc \u0111i\u1ec1u tr\u1ecb v\u00e0 \u0111\u1ea3m b\u1ea3o b\u00f9 n\u01b0\u1edbc \u0111\u1ea7y \u0111\u1ee7 tr\u01b0\u1edbc, trong v\u00e0 sau khi truy\u1ec1n acid zoledronic (c\u00f3 th\u1ec3 t\u1edbi 4 l\u00edt trong 24 gi\u1edd). Tuy nhi\u00ean, c\u0169ng kh\u00f4ng n\u00ean b\u00f9 qu\u00e1 nhi\u1ec1u n\u01b0\u1edbc c\u00f3 th\u1ec3 g\u00e2y suy tim. Ti\u1ebfp t\u1ee5c \u0111\u00e1nh gi\u00e1 ch\u1ee9c n\u0103ng th\u1eadn tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 y\u1ebfu t\u1ed1 nguy c\u01a1 nh\u01b0: \u0111\u00e3 c\u00f3 suy th\u1eadn tr\u01b0\u1edbc \u0111\u00f3, b\u1ec7nh nh\u00e2n tu\u1ed5i cao, \u0111ang d\u00f9ng thu\u1ed1c c\u00f3 \u0111\u1ed9c v\u1edbi th\u1eadn, thu\u1ed1c l\u1ee3i ti\u1ec3u ho\u1eb7c \u0111ang trong t\u00ecnh tr\u1ea1ng m\u1ea5t n\u01b0\u1edbc.<\/p>\n

4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/strong><\/p>\n

C\u00e1c thu\u1ed1c l\u1ee3i ni\u1ec7u quai, kh\u00e1ng sinh nh\u00f3m aminoglycosid c\u00f3 th\u1ec3 hi\u1ec7p \u0111\u1ed3ng t\u00e1c d\u1ee5ng l\u00e0m t\u0103ng nguy c\u01a1 gi\u1ea3m Ca++ m\u00e1u c\u1ee7a acid zoledronic.<\/p>\n

C\u00e1c thu\u1ed1c c\u00f3 \u0111\u1ed9c t\u00ednh v\u1edbi th\u1eadn, c\u00e1c thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid, thalidomid l\u00e0m t\u0103ng nguy c\u01a1 ADR tr\u00ean th\u1eadn c\u1ee7a acid zoledronic. Kh\u00f4ng \u0111\u01b0\u1ee3c tr\u1ed9n l\u1eabn v\u1edbi dung d\u1ecbch calci ho\u1eb7c c\u00e1c dung d\u1ecbch ti\u00eam truy\u1ec1n c\u00f3 cation h\u00f3a tr\u1ecb 2 nh\u01b0 dung d\u1ecbch Ringer lactat.<\/p>\n

4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/strong><\/p>\n

Qu\u00e1 li\u1ec1u acid zoledronic c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c bi\u1ec3u hi\u1ec7n c\u1ee7a t\u00ecnh tr\u1ea1ng gi\u1ea3m calci m\u00e1u. \u0110\u1ec3 kh\u1eafc ph\u1ee5c, c\u00f3 th\u1ec3 truy\u1ec1n calci qua \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch. C\u1ea7n ch\u00fa \u00fd ch\u1ee9c n\u0103ng th\u1eadn v\u00ec acid zoledronic c\u00f3 th\u1ec3 g\u00e2y suy th\u1eadn.<\/p>\n

5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/strong><\/p>\n

5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/strong><\/p>\n

Acid zoledronic l\u00e0 m\u1ed9t bisphosphonat t\u1ed5ng h\u1ee3p, thu\u1ed9c d\u1eabn xu\u1ea5t imidazol. acid zoledronic, l\u00e0 m\u1ed9t ch\u1ea5t thu\u1ed9c nh\u00f3m bisphosphonat, c\u00f3 t\u00e1c d\u1ee5ng \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n lo\u00e3ng x\u01b0\u01a1ng do l\u00e0m \u1ee9c ch\u1ebf t\u1ebf b\u00e0o h\u1ee7y x\u01b0\u01a1ng, gi\u00fap t\u0103ng c\u01b0\u1eddng m\u1eadt \u0111\u1ed9 x\u01b0\u01a1ng v\u00e0 s\u1ef1 trao \u0111\u1ed5i ch\u1ea5t trong x\u01b0\u01a1ng \u1edf ph\u1ee5 n\u1eef sau m\u00e3n kinh. Thu\u1ed1c l\u00e0m gi\u1ea3m 70% nguy c\u01a1 g\u00e3y x\u01b0\u01a1ng s\u1ed1ng v\u00e0 28% nguy c\u01a1 t\u1eed vong sau g\u00e3y x\u01b0\u01a1ng.<\/p>\n

Tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n t\u0103ng calci m\u00e1u do kh\u1ed1i u \u00e1c t\u00ednh, acid zoledronic l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 calci v\u00e0 phospho huy\u1ebft, \u0111\u1ed3ng th\u1eddi t\u0103ng b\u00e0i ti\u1ebft c\u00e1c ch\u1ea5t n\u00e0y ra n\u01b0\u1edbc ti\u1ec3u.<\/p>\n

Nghi\u00ean c\u1ee9u l\u00e2u d\u00e0i tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y acid zoledronic \u1ee9c ch\u1ebf ti\u00eau x\u01b0\u01a1ng nh\u01b0ng kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng x\u1ea5u \u0111\u1ebfn t\u1ea1o x\u01b0\u01a1ng, kho\u00e1ng h\u00f3a ho\u1eb7c \u0111\u1ed9c t\u00ednh c\u01a1 h\u1ecdc c\u1ee7a x\u01b0\u01a1ng. Ngo\u00e0i t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf m\u1ea1nh tr\u00ean x\u01b0\u01a1ng, acid zoledronic c\u00f2n c\u00f3 nhi\u1ec1u \u0111\u1eb7c t\u00ednh kh\u00e1ng u, g\u00f3p ph\u1ea7n mang l\u1ea1i hi\u1ec7u qu\u1ea3 to\u00e0n b\u1ed9 trong \u0111i\u1ec1u tr\u1ecb di c\u0103n v\u00e0o x\u01b0\u01a1ng. C\u00e1c \u0111\u1eb7c t\u00ednh sau \u0111\u00e2y \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh trong c\u00e1c nghi\u00ean c\u1ee9u ti\u1ec1n l\u00e2m s\u00e0ng:<\/p>\n

In vivo,<\/em> \u1ee9c ch\u1ebf ti\u00eau x\u01b0\u01a1ng do h\u1ee7y c\u1ed1t b\u00e0o l\u00e0m thay \u0111\u1ed5i vi m\u00f4i tr\u01b0\u1eddng t\u1ee7y x\u01b0\u01a1ng g\u00e2y b\u1ea5t l\u1ee3i cho s\u1ef1 ph\u00e1t tri\u1ec3n c\u00e1c t\u1ebf b\u00e0o u, l\u00e0m gi\u1ea3m ho\u1ea1t t\u00ednh sinh m\u1ea1ch m\u00e1u v\u00e0 c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng \u0111au.<\/p>\n

In vitro,<\/em> \u1ee9c ch\u1ebf t\u0103ng sinh nguy\u00ean c\u1ed1t b\u00e0o, c\u00f3 ho\u1ea1t t\u00ednh k\u00ecm t\u1ebf b\u00e0o tr\u1ef1c ti\u1ebfp v\u00e0 l\u00e0m ch\u1ebft c\u00e1c t\u1ebf b\u00e0o u, hi\u1ec7p \u0111\u1ed3ng t\u00e1c d\u1ee5ng k\u00ecm t\u1ebf b\u00e0o k\u1ebft h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c ch\u1ed1ng ung th\u01b0 kh\u00e1c, t\u00e1c d\u1ee5ng ch\u1ed1ng b\u00e1m d\u00ednh, x\u00e2m l\u1ea5n t\u1ebf b\u00e0o.<\/p>\n

C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n

Acid zoledronic c\u00f3 c\u1ea5u tr\u00fac v\u00e0 t\u00e1c d\u1ee5ng t\u01b0\u01a1ng t\u1ef1 c\u00e1c bisphosphonat kh\u00e1c nh\u01b0 alendronat, risedronat, v\u00e0 pamidronat. C\u00e1c bisphosphonat \u0111\u1ec1u l\u00e0 c\u00e1c ch\u1ea5t t\u01b0\u01a1ng t\u1ef1 pyrophosphat, c\u00f3 \u00e1i l\u1ef1c cao v\u1edbi hydroxyapatit c\u1ee7a x\u01b0\u01a1ng v\u00e0 \u1ee9c ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a c\u00e1c t\u1ebf b\u00e0o h\u1ee7y x\u01b0\u01a1ng. C\u00e1c bisphosphonat c\u0169ng \u1ee9c ch\u1ebf s\u1ef1 t\u1ea1o th\u00e0nh v\u00e0 h\u00f2a tan c\u00e1c tinh th\u1ec3 hydroxyapatit, do \u0111\u00f3 c\u00f3 ti\u1ec1m n\u0103ng \u1ee9c ch\u1ebf qu\u00e1 tr\u00ecnh kho\u00e1ng h\u00f3a x\u01b0\u01a1ng.<\/p>\n

Acid zoledronic \u1ee9c ch\u1ebf ho\u1ea1t t\u00ednh c\u1ee7a c\u00e1c t\u1ebf b\u00e0o h\u1ee7y x\u01b0\u01a1ng v\u00e0 s\u1ef1 gi\u1ea3i ph\u00f3ng calci t\u1eeb c\u00e1c kh\u1ed1i u, do \u0111\u00f3 l\u00e0m gi\u1ea3m calci m\u00e1u.<\/p>\n

[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/p>\n

5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/strong><\/p>\n

N\u1ed3ng \u0111\u1ed9 acid zoledronic trong huy\u1ebft t\u01b0\u01a1ng t\u0103ng l\u00ean nhanh ch\u00f3ng ngay sau khi truy\u1ec1n t\u0129nh m\u1ea1ch. T\u1ef7 l\u1ec7 g\u1eafn v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng th\u1ea5p v\u00e0 r\u1ea5t kh\u00e1c nhau gi\u1eefa c\u00e1c nghi\u00ean c\u1ee9u, kho\u1ea3ng t\u1eeb 22% \u0111\u1ebfn 56%. Acid zoledronic kh\u00f4ng b\u1ecb chuy\u1ec3n h\u00f3a, kho\u1ea3ng 23 – 55% li\u1ec1u d\u00f9ng \u0111\u01b0\u1ee3c th\u1ea3i qua th\u1eadn d\u01b0\u1edbi d\u1ea1ng kh\u00f4ng \u0111\u1ed5i trong v\u00f2ng 24 gi\u1edd, ph\u1ea7n c\u00f2n l\u1ea1i ch\u1ee7 y\u1ebfu l\u01b0u gi\u1eef \u1edf x\u01b0\u01a1ng v\u00e0 \u0111\u00e0o th\u1ea3i r\u1ea5t ch\u1eadm. N\u1eeda \u0111\u1eddi th\u1ea3i tr\u1eeb cu\u1ed1i c\u00f9ng kho\u1ea3ng 146 gi\u1edd. T\u1ed1c \u0111\u1ed9 th\u1ea3i tr\u1eeb acid zoledronic qua th\u1eadn gi\u1ea3m xu\u1ed1ng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng.<\/p>\n

5.3 Gi\u1ea3i th\u00edch: <\/strong><\/p>\n

Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n

5.4 Thay th\u1ebf thu\u1ed1c : <\/strong><\/p>\n

Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n

*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n

C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o – Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n

Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n

6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/strong><\/p>\n

6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/strong><\/p>\n

Mannitol, Sodium citrate, Water for injections<\/p>\n

6.2. T\u01b0\u01a1ng k\u1ef5 :<\/strong><\/p>\n

Kh\u00f4ng \u00e1p d\u1ee5ng.<\/p>\n

6.3. B\u1ea3o qu\u1ea3n: <\/strong><\/p>\n

Dung d\u1ecbch ti\u00eam c\u00f3 ch\u1ee9a acid zoledronic \u0111\u01b0\u1ee3c b\u1ea3o qu\u1ea3n \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng 25 o<\/sup>C, ho\u1eb7c trong ph\u1ea1m vi t\u1eeb 15 – 30 o<\/sup>C. Dung d\u1ecbch truy\u1ec1n \u0111\u00e3 pha th\u00e0nh 100 ml trong natri clorid 0,9% ho\u1eb7c glucose 5% \u1ed5n \u0111\u1ecbnh trong 24 gi\u1edd \u1edf 4 – 8 o<\/sup>C.<\/p>\n

6.4. Th\u00f4ng tin kh\u00e1c :<\/strong><\/p>\n

Kh\u00f4ng c\u00f3.<\/p>\n

6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/strong><\/p>\n

D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Zoledronic acid Ph\u00e2n lo\u1ea1i: Thu\u1ed1c \u1ee9c ch\u1ebf ti\u00eau x\u01b0\u01a1ng, \u0111i\u1ec1u tr\u1ecb lo\u00e3ng x\u01b0\u01a1ng nh\u00f3m Bisphosphonates. Nh\u00f3m ph\u00e1p l\u00fd: Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine) M\u00e3 ATC (Anatomical Therapeutic Chemical): M05BA08. Brand name: Aclasta, Zometa. Generic : Zoledronic acid, Acido […]<\/p>\n","protected":false},"author":1,"featured_media":14684,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[2],"tags":[529],"class_list":["post-2492","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-thuoc-a-z","tag-zoledronic-acid"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/2492","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=2492"}],"version-history":[{"count":3,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/2492\/revisions"}],"predecessor-version":[{"id":14685,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/2492\/revisions\/14685"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/14684"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=2492"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=2492"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=2492"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}