{"id":22680,"date":"2020-09-17T11:26:36","date_gmt":"2020-09-17T04:26:36","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=22680"},"modified":"2025-01-08T20:50:40","modified_gmt":"2025-01-08T13:50:40","slug":"enalapril-hasitec","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/enalapril-hasitec\/","title":{"rendered":"Enalapril &#8211; Hasitec\/Enamigal"},"content":{"rendered":"<p><strong>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: <\/strong><\/p>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <\/strong><a href=\"https:\/\/pharmog.com\/wp\/enalapril\/\"><strong>Enalapril<\/strong><\/a><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u1ed1c nh\u00f3m \u1ee9c ch\u1ebf enzym chuy\u1ec3n angiotensin..<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): C09AA02.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em><\/strong> <a href=\"https:\/\/pharmog.com\/wp\/enalapril-renitec\/\">Renitec<\/a><\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c:<\/em><\/strong> Hasitec, Enamigal<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: C\u00f4ng ty TNHH Hasan-Dermapharm<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng: <\/strong><\/p>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>Vi\u00ean n\u00e9n 5 mg, 10 mg.<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>HASITEC 5MG<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean n\u00e9n c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Enalapril maleat<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>5 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"473\" height=\"292\" class=\"wp-image-22681\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/09\/word-image-207.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/09\/word-image-207.png 473w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/09\/word-image-207-300x185.png 300w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/09\/word-image-207-259x160.png 259w\" sizes=\"auto, (max-width: 473px) 100vw, 473px\" \/><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>HASITEC 10MG<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean n\u00e9n c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Enalapril maleat<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>10 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"472\" height=\"272\" class=\"wp-image-22682\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/09\/word-image-208.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/09\/word-image-208.png 472w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/09\/word-image-208-300x173.png 300w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/09\/word-image-208-278x160.png 278w\" sizes=\"auto, (max-width: 472px) 100vw, 472px\" \/><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>ENAMIGAL 10MG<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean n\u00e9n c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Enalapril maleat<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>10 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"574\" height=\"282\" class=\"wp-image-22683\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/09\/word-image-209.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/09\/word-image-209.png 574w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/09\/word-image-209-300x147.png 300w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/09\/word-image-209-280x138.png 280w\" sizes=\"auto, (max-width: 574px) 100vw, 574px\" \/><\/p>\n<p><strong>3. Video by Pharmog:<\/strong><\/p>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe loading=\"lazy\" title=\"[Pharmog SS1 - T\u1eadp 11] - D\u01b0\u1ee3c l\u00fd v\u1ec1 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/F1Pl4DO5flA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<p><strong>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng: <\/strong><\/p>\n<p><strong>4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>T\u0103ng huy\u1ebft \u00e1p.<\/p>\n<p>Suy tim (gi\u1ea3m t\u1eed vong v\u00e0 bi\u1ebfn ch\u1ee9ng \u1edf b\u1ec7nh nh\u00e2nsuy tim c\u00f3 tri\u1ec7u ch\u1ee9ng v\u00e0 b\u1ec7nh nh\u00e2n lo\u1ea1n ch\u1ee9c n\u0103ng th\u1ea5t tr\u00e1i kh\u00f4ng tri\u1ec7u ch\u1ee9ng).<\/p>\n<p>Sau nh\u1ed3i m\u00e1u c\u01a1 tim (huy\u1ebft \u0111\u1ed9ng h\u1ecdc \u0111\u00e3 \u1ed5n \u0111\u1ecbnh).<\/p>\n<p>B\u1ec7nh th\u1eadn do \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng (t\u0103ng ho\u1eb7c kh\u00f4ng t\u0103ng huy\u1ebft \u00e1p).<\/p>\n<p>Suy th\u1eadn tu\u1ea7n ti\u1ebfn m\u1ea1n.<\/p>\n<p><strong>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/strong><\/p>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p>Thu\u1ed1c d\u00f9ng theo \u0111\u01b0\u1eddng u\u1ed1ng , u\u1ed1ng nguy\u00ean c\u1ea3 vi\u00ean v\u1edbi n\u01b0\u1edbc .<\/p>\n<p>Th\u1eddi gian d\u00f9ng thu\u1ed1c do b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb quy\u1ebft \u0111\u1ecbnh.<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p>Li\u1ec1u l\u01b0\u1ee3ng c\u1ee7a thu\u1ed1c ph\u1ea3i \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh t\u1ee7y theo t\u1eebng c\u00e1 th\u1ec3.<\/p>\n<p>Ng\u01b0\u1eddi l\u1edbn:<\/p>\n<p>Tang huy\u1ebft \u00e1p v\u00f4 can:<\/p>\n<p>+ Li\u1ec1u kh\u1edfi \u0111\u1ea7u: 2,5 &#8211; 5,0 mg\/ng\u00e0y.<\/p>\n<p>+ Li\u1ec1u duy tr\u00ec: 10 &#8211; 20 mg\/l\u1ea7n\/ng\u00e0y. \u0110i\u1ec1u ch\u1ec9nh li\u1ec1u theo \u0111\u00e1p \u1ee9ng v\u1ec1 huy\u1ebft \u00e1p c\u1ee7a b\u1ec7nh nh\u00e2n.<\/p>\n<p>+ Li\u1ec1u t\u1ed1i \u0111a: 40 mg\/ng\u00e0y.<\/p>\n<p>&#8211; \u0110i\u1ec1u tr\u1ecb \u0111\u1ed3ng th\u1eddi v\u1edbi thu\u1ed1c l\u1ee3i ti\u1ec3u: Ng\u1eebng thu\u1ed1c l\u1ee3i ti\u1ec3u (n\u1ebfu c\u00f3 th\u1ec3) trong 1 &#8211; 3 ng\u00e0y tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Enalapril v\u00e0 c\u1ea7n thi\u1ebft ph\u1ea3i d\u00f9ng thu\u1ed1c v\u1edbi li\u1ec1u ban \u0111\u1ea7u r\u1ea5t th\u1ea5p, 5 mg\/ng\u00e0y ho\u1eb7c \u00edt h\u01a1n. T\u0103ng d\u1ea7n li\u1ec1u m\u1ed9t c\u00e1ch th\u1eadn tr\u1ecdng theo \u0111\u00e1p \u1ee9ng \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>&#8211; Suy tim:<\/p>\n<p>+ Trong tu\u1ea7n \u0111\u1ea7u ti\u1ec1n: 2,5 mg\/l\u1ea7n\/ng\u00e0y, trong 3 ng\u00e0y \u0111\u1ea7u; 2,5 mg<\/p>\n<p>X2 l\u1ea7n\/ng\u00e0y, trong 4 ng\u00e0y ti\u1ebfp theo.<\/p>\n<p>+ Sau \u0111\u00f3 c\u00f3 th\u1ec3 t\u0103ng li\u1ec1u d\u1ea7n t\u1edbi li\u1ec1u duy tr\u00ec b\u00ecnh th\u01b0\u1eddng 20 mg\/ng\u00e0y, d\u00f9ng 1 l\u1ea7n ho\u1eb7c chia th\u00e0nh 2 l\u1ea7n, d\u00f9ng v\u00e0o bu\u1ed5i s\u00e1ng v\u00e0 bu\u1ed5i t\u1ed1i. Trong m\u1ed9t s\u1ed1 hi\u1ebfm tr\u01b0\u1eddng h\u1ee3p, c\u00f3 th\u1ec3 ph\u1ea3i t\u0103ng li\u1ec1u t\u1edbi 40 mg\/ng\u00e0y. \u0110i\u1ec1u ch\u1ec9nh li\u1ec1u trong 2 &#8211; 4 tu\u1ea7n.<\/p>\n<p>+ Suy ch\u1ee9c n\u0103ng th\u1ea5t tr\u00e1i kh\u00f4ng tri\u1ec7u ch\u1ee9ng:<\/p>\n<p>+ Li\u1ec1u kh\u1edfi \u0111\u1ea7u: 2,5 mg x 2 l\u1ea7n\/ng\u00e0y, v\u00e0o bu\u1ed5i s\u00e1ng v\u00e0 bu\u1ed5i t\u1ed1i.<\/p>\n<p>+ \u0110i\u1ec1u ch\u1ec9nh li\u1ec1u li\u00ean t\u1ee5c cho t\u1edbi li\u1ec1u ph\u00f9 h\u1ee3p. C\u00f3 th\u1ec3 t\u0103ng d\u1ea7n li\u1ec1u \u0111\u1ebfn 20 mg\/ng\u00e0y, chia l\u00e0m 2 l\u1ea7n v\u00e0o bu\u1ed5i s\u00e1ng v\u00e0 bu\u1ed5i t\u1ed1i<\/p>\n<p>&#8211; B\u1ec7nh th\u1eadn do \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng:<\/p>\n<p>+ Li\u1ec1u kh\u1edfi \u0111\u1ea7u: 5,0 mg\/l\u1ea7n\/ng\u00e0y.<\/p>\n<p>+ Li\u1ec1u duy tr\u00ec t\u1eeb 10 &#8211; 40 mg\/ng\u00e0y, d\u00f9ng 1 l\u1ea7n ho\u1eb7c chia th\u00e0nh 2 l\u1ea7n<\/p>\n<p>&#8211; B\u1ec7nh nh\u00e2n suy th\u1eadn:<\/p>\n<p>C\u1ea7n ph\u1ea3i gi\u1ea3m li\u1ec1u ho\u1eb7c k\u00e9o d\u00e0i kho\u1ea3ng c\u00e1ch gi\u1eefa c\u00e1c li\u1ec1u:<\/p>\n<table>\n<tbody>\n<tr>\n<td>\u0110\u1ed9 thanh th\u1ea3i creatinin(ml\/ph\u00fat)<\/td>\n<td>Li\u1ec1u ban \u0111\u1ea7u(mg\/ng\u00e0y)<\/td>\n<\/tr>\n<tr>\n<td>80 &#8211; 30<\/td>\n<td>5,0- 10<\/td>\n<\/tr>\n<tr>\n<td>29-10<\/td>\n<td>2,5 -5,0<\/td>\n<\/tr>\n<tr>\n<td>&lt;10<\/td>\n<td>25<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Enalapril \u0111\u01b0\u1ee3c lo\u1ea1i tr\u1eeb b\u1eb1ng th\u1ea9m t\u00e1ch m\u00e1u. D\u00f9ng 2,5 mg<\/p>\n<p>Enalapril trong ng\u00e0y th\u1ea9m t\u00e1ch m\u00e1u cho b\u1ec7nh nh\u00e2n gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn n\u1eb7ng \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng th\u1ea9m t\u00e1ch m\u00e1u. Nh\u1eefng ng\u00e0y ti\u1ebfp theo \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u theo huy\u1ebft \u00e1p.<\/p>\n<p>Tr\u1ebb em: T\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a Enalapril \u1edf tr\u1ebb em ch\u01b0a \u0111\u01b0\u1ee3c ch\u1ee9ng minh.<\/p>\n<p><strong>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>Qu\u00e1 m\u1eabn v\u1edbi Enalapril ho\u1eb7c v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p>Ph\u00f9 m\u1ea1ch khi m\u1edbi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb nh\u01b0 c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf ACE n\u00f3i chung.<\/p>\n<p>H\u1eb9p \u0111\u1ed9ng m\u1ea1ch th\u1eadn hai b\u00ean th\u1eadn ho\u1eb7c h\u1eb9p \u0111\u1ed9ng mach th\u1eadn \u1edf b\u1ec7nh nh\u00e2n ch\u1ec9 c\u00f3 m\u1ed9t th\u1eadn.<\/p>\n<p>H\u1eb9p van \u0111\u1ed9ng m\u1ea1ch ch\u1ee7 v\u00e0 b\u1ec7nh c\u01a1 tim t\u1eafc ngh\u1ebdn n\u1eb7ng.<\/p>\n<p>H\u1ea1 huy\u1ebft \u00e1p c\u00f3 tr\u01b0\u1edbc.<\/p>\n<p><strong>4.4 Th\u1eadn tr\u1ecdng:<\/strong><\/p>\n<p>B\u1ec7nh nh\u00e2n gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn: c\u1ea7n ph\u1ea3i \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u, \u0111\u1eb7c bi\u1ec7t trong khi \u0111i\u1ec1u tr\u1ecb k\u1ebft h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c h\u1ea1 huy\u1ebft \u00e1p kh\u00e1c.<\/p>\n<p>Trong v\u00f2ng 4 tu\u1ea7n, n\u1ebfu kh\u00f4ng \u0111\u1ea1t \u0111\u01b0\u1ee3c k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb, ph\u1ea3i t\u0103ng li\u1ec1u ho\u1eb7c ph\u1ea3i c\u00e2n nh\u1eafc d\u00f9ng th\u00eam thu\u1ed1c ch\u1ed1ng t\u0103ng huy\u1ebft \u00e1p kh\u00e1c.<\/p>\n<p>B\u1ec7nh nh\u00e2n nghi b\u1ecb h\u1eb9p \u0111\u1ed9ng m\u1ea1ch th\u1eadn: c\u1ea7n ph\u1ea3i \u0111\u1ecbnh l\u01b0\u1ee3ng creatinin m\u00e1u tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>B\u1ec7nh nh\u00e2n c\u00f3 suy tim n\u1eb7ng (\u0111\u1ed9 4), suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn v\u00e0\/ho\u1eb7c chi\u1ec1u h\u01b0\u1edbng b\u1ea5t th\u01b0\u1eddng v\u1ec1 \u0111i\u1ec7n gi\u1ea3i: ph\u1ea3i \u0111\u01b0\u1ee3c theo d\u00f5i c\u1ea9n th\u1eadn t\u1ea1i b\u1ec7nh vi\u1ec7n ngay t\u1eeb khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb. Nguy\u00ean t\u1eafc n\u00e0y c\u0169ng \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng khi ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c gi\u00e3n m\u1ea1ch.<\/p>\n<p>B\u1ec7nh nh\u00e2n suy ch\u1ee9c n\u0103ng th\u1ea5t tr\u00e1i kh\u00f4ng tri\u1ec7u ch\u1ee9ng: ph\u1ea3i theo d\u00f5i huy\u1ebft \u00e1p v\u00e0 ch\u1ee9c n\u0103ng th\u1eadn ch\u1eb7t ch\u1ebd tr\u01b0\u1edbc v\u00e0 sau khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb \u0111\u1ec3 tr\u00e1nh h\u1ea1 huy\u1ebft \u00e1p n\u1eb7ng v\u00e0 suy th\u1eadn. N\u1ebfu c\u00f3 th\u1ec3, n\u00ean gi\u1ea3m li\u1ec1u thu\u1ed1c l\u1ee3i ti\u1ec3u tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Enalapril. N\u00ean theo d\u00f5i n\u1ed3ng \u0111\u1ed9 kali huy\u1ebft thanh v\u00e0 \u0111i\u1ec1u ch\u1ec9nh v\u1ec1 m\u1ee9c b\u00ecnh th\u01b0\u1eddng<\/p>\n<p>\u0110\u00e3 c\u00f3 tr\u01b0\u1eddng h\u1ee3p h\u1ea1 huy\u1ebft \u00e1p tri\u1ec7u ch\u1ee9ng n\u1eb7ng sau khi d\u00f9ng li\u1ec1u Enalapril \u0111\u1ea7u ti\u00ean v\u00e0 c\u00f3 2 &#8211; 3% s\u1ed1 ng\u01b0\u1eddi trong th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng ph\u1ea3i ng\u1eebng \u0111i\u1ec1u tr\u1ecb. H\u1ea1 huy\u1ebft \u00e1p ban \u0111\u1ea7u th\u01b0\u1eddng kh\u00f4ng c\u00f3 ngh\u0129a l\u00e0 t\u00e1c d\u1ee5ng n\u00e0y s\u1ebd duy tr\u00ec trong su\u1ed1t \u0111\u1ee3t \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>Enalapril c\u00f3 th\u1ec3 g\u00e2y hoa m\u1eaft, ch\u00f3ng m\u1eb7t \u1edf m\u1ed9t s\u1ed1 ng\u01b0\u1eddi. V\u00ec v\u1eady, n\u1ebfu c\u00f3 bi\u1ec3u hi\u1ec7n n\u00e0y, c\u1ea7n tr\u00e1nh v\u1eadn h\u00e0nh t\u00e0u xe, m\u00e1y m\u00f3c ho\u1eb7c c\u00e1c ho\u1ea1t \u0111\u1ed9ng c\u1ea7n s\u1ef1 t\u1ec9nh t\u00e1o.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/strong><\/p>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: D<\/p>\n<p>US FDA pregnancy category: D<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>Enalapril c\u00f3 th\u1ec3 g\u00e2y b\u1ec7nh v\u00e0 t\u1eed vong cho thai nhi v\u00e0 tr\u1ebb s\u01a1 sinh khi ng\u01b0\u1eddi m\u1eb9 mang thai s\u1eed d\u1ee5ng thu\u1ed1c. S\u1eed d\u1ee5ng thu\u1ed1c trong 3 th\u00e1ng gi\u1eefa v\u00e0 3 th\u00e1ng cu\u1ed1i c\u1ee7a thai k\u1ef3 c\u00f3 th\u1ec3 g\u00e2y b\u1ec7nh d\u1eabn \u0111\u1ebfn ch\u1ebft thai v\u00e0 t\u1ed5n th\u01b0\u01a1ng cho tr\u1ebb s\u01a1 sinh, bao g\u1ed3m h\u1ea1 huy\u1ebft \u00e1p, gi\u1ea3m s\u1ea3n s\u1ecd s\u01a1 sinh, suy th\u1eadn h\u1ed3i ph\u1ee5c ho\u1eb7c kh\u00f4ng h\u1ed3i ph\u1ee5c v\u00e0 t\u1eed vong. Ph\u1ea3i ng\u1eebng d\u00f9ng Enalapril c\u00e0ng s\u1edbm c\u00e0ng t\u1ed1t sau khi ph\u00e1t hi\u1ec7n c\u00f3 thai.<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>Enalapril b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9. V\u1edbi li\u1ec1u \u0111i\u1ec1u tr\u1ecb th\u00f4ng th\u01b0\u1eddng, nguy c\u01a1 v\u1ec1 t\u00e1c d\u1ee5ng c\u00f3 h\u1ea1i cho tr\u1ebb b\u00fa s\u1eefa m\u1eb9 r\u1ea5t th\u1ea5p.<\/p>\n<p><strong>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/strong><\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p: nh\u1ee9c \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, m\u1ec7t m\u1ecfi, m\u1ea5t ng\u1ee7, d\u1ecb c\u1ea3m, lo\u1ea1n c\u1ea3m; r\u1ed1i lo\u1ea1n v\u1ecb gi\u00e1c, ti\u00eau ch\u1ea3y, bu\u1ed3n n\u00f4n, n\u00f4n, \u0111au b\u1ee5ng; ph\u00f9 m\u1ea1ch, h\u1ea1 huy\u1ebft \u00e1p n\u1eb7ng, h\u1ea1 huy\u1ebft \u00e1p t\u01b0 th\u1ebf \u0111\u1ee9ng, ng\u1ea5t, \u0111\u00e1nh tr\u1ed1ng ng\u1ef1c, \u0111au ng\u1ef1c; ph\u00e1t ban; ho khan; suy th\u1eadn.<\/p>\n<p>\u00cdt g\u1eb7p: gi\u1ea3m hemoglobin v\u00e0 hematocrit, gi\u1ea3m b\u1ea1ch c\u1ea7u h\u1ea1t, gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh; protein ni\u1ec7u; h\u1ed1t ho\u1ea3ng, k\u00edch \u0111\u1ed9ng, tr\u1ea7m c\u1ea3m n\u1eb7ng.<\/p>\n<p>Hi\u1ebfm g\u1eb7p: t\u1eafc ru\u1ed9t, vi\u00eam t\u1ee5y, vi\u00eam gan nhi\u1ec5m \u0111\u1ed9c \u1ee9 m\u1eadt, t\u0103ng c\u1ea3m ni\u00eam m\u1ea1c mi\u1ec7ng; qu\u00e1 m\u1eabn, tr\u1ea7m c\u1ea3m, nh\u00ecn m\u1edd, ng\u1ea1t m\u0169i, \u0111au c\u01a1, co th\u1eaft ph\u1ebf qu\u1ea3n v\u00e0 hen.<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<p><strong>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/strong><\/p>\n<p>Khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb, n\u00ean d\u00f9ng thu\u1ed1c v\u1edbi li\u1ec1u th\u1ea5p v\u00e0 ki\u1ec3m tra n\u1ed3ng \u0111\u1ed9 natri huy\u1ebft thanh.<\/p>\n<p>C\u00f3 th\u1ec3 x\u1ea3y ra ph\u00f9 m\u1ea1ch, \u0111\u1eb7c bi\u1ec7t sau khi d\u00f9ng li\u1ec1u enalapril \u0111\u1ea7u ti\u00ean, v\u00e0 n\u1ebfu c\u00f3 th\u00eam ph\u00f9 thanh qu\u1ea3n c\u00f3 th\u1ec3 g\u00e2y t\u1eed vong. C\u1ea7n th\u00f4ng b\u00e1o cho ng\u01b0\u1eddi b\u1ec7nh v\u1ec1 nh\u1eefng d\u1ea5u hi\u1ec7u v\u00e0 tri\u1ec7u ch\u1ee9ng c\u1ee7a ph\u00f9 m\u1ea1ch (ph\u00f9 m\u1eb7t, m\u1eaft, m\u00f4i, l\u01b0\u1ee1i, ho\u1eb7c kh\u00f3 th\u1edf), khi th\u1ea5y c\u00f3 tri\u1ec7u ch\u1ee9ng n\u00e0y ph\u1ea3i ng\u1eebng d\u00f9ng thu\u1ed1c v\u00e0 th\u00f4ng b\u00e1o ngay cho b\u00e1c s\u1ef9. \u0110i\u1ec1u tr\u1ecb ph\u00f9 m\u1ea1ch \u1edf l\u01b0\u1ee1i, thanh m\u00f4n ho\u1eb7c thanh qu\u1ea3n, bao g\u1ed3m c\u00e1c bi\u1ec7n ph\u00e1p sau:<\/p>\n<p>Ng\u1eebng d\u00f9ng enalapril v\u00e0 cho ng\u01b0\u1eddi b\u1ec7nh v\u00e0o vi\u1ec7n; ti\u00eam adrenalin d\u01b0\u1edbi da; ti\u00eam t\u0129nh m\u1ea1ch diphenhydramin hydroclorid; ti\u00eam t\u0129nh m\u1ea1ch hydrocortison.<\/p>\n<p>\u0110\u1ecbnh k\u1ef3 theo d\u00f5i v\u00e0 \u0111\u1ebfm b\u1ea1ch c\u1ea7u \u1edf ng\u01b0\u1eddi b\u1ec7nh s\u1eed d\u1ee5ng enalapril, \u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi suy th\u1eadn.<\/p>\n<p>Ph\u1ea3i theo d\u00f5i huy\u1ebft \u00e1p v\u00e0 ch\u1ee9c n\u0103ng th\u1eadn ch\u1eb7t ch\u1ebd tr\u01b0\u1edbc v\u00e0 sau khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>N\u1ebfu kh\u00f4ng \u0111\u1ea1t \u0111\u01b0\u1ee3c \u0111\u00e1p \u1ee9ng \u0111i\u1ec1u tr\u1ecb \u0111\u1ee7 trong v\u00f2ng 4 tu\u1ea7n, n\u00ean t\u0103ng li\u1ec1u d\u00f9ng ho\u1eb7c \u0111i\u1ec1u tr\u1ecb th\u00eam b\u1eb1ng nh\u1eefng thu\u1ed1c ch\u1ed1ng t\u0103ng huy\u1ebft \u00e1p kh\u00e1c.<\/p>\n<p>Khi c\u00f3 h\u1ea1 huy\u1ebft \u00e1p n\u1eb7ng c\u1ea7n truy\u1ec1n t\u0129nh m\u1ea1ch natri clorid 0,9%. Enalapril th\u01b0\u1eddng kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn n\u1ed3ng \u0111\u1ed9 kali huy\u1ebft thanh. N\u1ebfu d\u00f9ng enalapril c\u00f9ng v\u1edbi thu\u1ed1c l\u1ee3i ni\u1ec7u c\u00f3 th\u1ec3 gi\u1ea3m nguy c\u01a1 gi\u1ea3i ph\u00f3ng aldosteron th\u1ee9 ph\u00e1t c\u00f9ng v\u1edbi h\u1ea1 kali m\u00e1u. \u1eda ng\u01b0\u1eddi suy th\u1eadn, enalapril c\u00f3 th\u1ec3 g\u00e2y t\u0103ng n\u1ed3ng \u0111\u1ed9 kali huy\u1ebft thanh. B\u1edfi v\u1eady, kh\u00f4ng khuy\u1ebfn c\u00e1o d\u00f9ng thu\u1ed1c l\u1ee3i ni\u1ec7u gi\u1eef kali v\u00e0 thu\u1ed1c b\u1ed1 sung kali cho ng\u01b0\u1eddi b\u1ec7nh gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn v\u00ec c\u00f3 th\u1ec3 l\u00e0m t\u0103ng kali m\u00e1u. N\u1ebfu v\u1eabn c\u1ea7n ph\u1ea3i \u0111i\u1ec1u tr\u1ecb \u0111\u1ed3ng th\u1eddi v\u1edbi thu\u1ed1c l\u1ee3i ni\u1ec7u, ph\u1ea3i h\u1ebft s\u1ee9c th\u1eadn tr\u1ecdng v\u00e0 th\u01b0\u1eddng xuy\u00ean \u0111o kali huy\u1ebft. C\u1ea7n ph\u1ea3i \u0111o creatinin huy\u1ebft tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb thu\u1ed1c cho ng\u01b0\u1eddi b\u1ec7nh c\u00f3 nghi ng\u1edd h\u1eb9p \u0111\u1ed9ng m\u1ea1ch th\u1eadn.<\/p>\n<p>Trong ph\u1eabu thu\u1eadt l\u1edbn ho\u1eb7c trong khi g\u00e2y m\u00ea b\u1eb1ng thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p, enalapril c\u00f3 th\u1ec3 ng\u0103n c\u1ea3n t\u1ea1o angiotensin II, sau khi c\u00f3 gi\u1ea3i ph\u00f3ng renin b\u00f9 tr\u1eeb d\u1eabn \u0111\u1ebfn h\u1ea1 huy\u1ebft \u00e1p k\u1ecbch ph\u00e1t, c\u1ea7n \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh b\u1eb1ng t\u0103ng th\u1ec3 t\u00edch tu\u1ea7n ho\u00e0n<\/p>\n<p><strong>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/strong><\/p>\n<p>M\u1ed9t s\u1ed1 thu\u1ed1c gi\u00e3n m\u1ea1ch kh\u00e1c (nh\u01b0 nitrat) ho\u1eb7c c\u00e1c thu\u1ed1c g\u00e2y m\u00ea: s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi Enalapril c\u00f3 th\u1ec3 g\u00e2y h\u1ea1 huy\u1ebft \u00e1p tr\u1ea7m tr\u1ecdng.<\/p>\n<p>Thu\u1ed1c l\u1ee3i ti\u1ec3u: th\u1ec9nh tho\u1ea3ng c\u00f3 th\u1ec3 g\u00e2y h\u1ea1 huy\u1ebft \u00e1p qu\u00e1 m\u1ee9c sau khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb v\u1edbi Enalapril.<\/p>\n<p>C\u00e1c thu\u1ed1c g\u00e2y gi\u1ea3i ph\u00f3ng renin (nh\u01b0 thu\u1ed1c l\u1ee3i ti\u1ec3u): t\u0103ng t\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p c\u1ee7a Enalapril.<\/p>\n<p>C\u00e1c thu\u1ed1c l\u00e0m t\u0103ng kali huy\u1ebft thanh (nh\u01b0 thu\u1ed1c l\u1ee3i ni\u1ec7u gi\u1eef kali, c\u00e1c ch\u1ea5t b\u1ed5 sung kali ho\u1eb7c mu\u1ed1i ch\u1ee9a kali): s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi<\/p>\n<p>Enalapril c\u00f3 th\u1ec3 g\u00e2y t\u0103ng kali huy\u1ebft thanh, \u0111\u1eb7c bi\u1ec7t \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn, do \u0111\u00f3 n\u00ean theo d\u00f5i b\u1ec7nh nh\u00e2n ch\u1eb7t ch\u1ebd v\u00e0 th\u01b0\u1eddng xuy\u00ean theo d\u00f5i n\u1ed3ng \u0111\u1ed9 kali huy\u1ebft.<\/p>\n<p>Lithi: Enalapril c\u00f3 th\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 lithi huy\u1ebft d\u1eabn \u0111\u1ebfn nhi\u1ec5m \u0111\u1ed9c lithi.<\/p>\n<p>C\u00e1c thu\u1ed1c gi\u00e3n ph\u1ebf qu\u1ea3n ki\u1ec3u giao c\u1ea3m, c\u00e1c thu\u1ed1c kh\u00e1ng vi\u00eam kh\u00f4ng steroid (NSAID): c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p c\u1ee7a Enalapril.<\/p>\n<p>C\u00e1c thu\u1ed1c u\u1ed1ng tr\u00e1nh thai: s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi Enalapril g\u00e2y t\u0103ng nguy c\u01a1 t\u1ed5n th\u01b0\u01a1ng m\u1ea1ch v\u00e0 kh\u00f3 ki\u1ec3m so\u00e1t huy\u1ebft \u00e1p.<\/p>\n<p>C\u00e1c thu\u1ed1c ch\u1eb9n beta &#8211; adrenergic, methyldopa, c\u00e1c nitrat, thu\u1ed1c ch\u1eb9n calci, hydralazin, prazosin v\u00e0 digoxin: kh\u00f4ng cho th\u1ea5y t\u00e1c d\u1ee5ng ph\u1ee5 c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng.<\/p>\n<p><strong>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/strong><\/p>\n<p>Tri\u1ec7u ch\u1ee9ng: \u0111\u1eb7c \u0111i\u1ec3m n\u1ed5i b\u1eadt c\u1ee7a qu\u00e1 li\u1ec1u Enalapril l\u00e0 h\u1ea1 huy\u1ebft \u00e1p n\u1eb7ng<\/p>\n<p>X\u1eed tr\u00ed: n\u00ean ng\u01b0ng \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Enalapril va theo d\u00f5i b\u1ec7nh nh\u00e2n ch\u1eb7t ch\u1ebd, \u00e1p d\u1ee5ng c\u00e1c bi\u1ec7n ph\u00e1p \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng v\u00e0 h\u1ed7 tr\u1ee3 nh\u01b0 g\u00e2y n\u00f4n, r\u1eeda d\u1ea1 d\u00e0y, truy\u1ec1n t\u0129nh m\u1ea1ch huy\u1ebft t\u01b0\u01a1ng v\u00e0 natri clorid \u0111\u1ec3 duy tr\u00ec huy\u1ebft \u00e1p v\u00e0 \u0111i\u1ec1u tr\u1ecb m\u1ea5t c\u00e2n b\u1eb1ng \u0111i\u1ec7n gi\u1ea3i. Th\u1ea9m t\u00e1ch m\u00e1u c\u00f3 th\u1ec3 lo\u1ea1i Enalapril kh\u1ecfi tu\u1ea7n ho\u00e0n.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/strong><\/p>\n<p><strong>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/strong><\/p>\n<p>Enalapril la thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n angiotensin (ACE) chuy\u1ec3n h\u00f3a angiotensin I thanh angiotensin II (ch\u1ea5t g\u00e2y co m\u1ea1ch m\u1ea1nh), c\u00f3 t\u00e1c d\u1ee5ng nh\u1edd enalaprilat l\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a Enalapril sau khi u\u1ed1ng. Enalapril l\u00e0m gi\u1ea3m huy\u1ebft \u00e1p \u1edf ng\u01b0\u1eddi huy\u1ebft \u00e1p b\u00ecnh th\u01b0\u1eddng, ng\u01b0\u1eddi t\u0103ng huy\u1ebft \u00e1p, v\u00e0 c\u00f3 t\u00e1c d\u1ee5ng t\u1ed1t \u0111\u1ebfn huy\u1ebft \u0111\u1ed9ng \u1edf ng\u01b0\u1eddi suy tim sung huy\u1ebft, ch\u1ee7 y\u1ebfu do \u1ee9c ch\u1ebf h\u1ec7 renin &#8211; angiotensin &#8211; aldosteron. Enalapril c\u0169ng l\u00e0m gi\u1ea3m aldosteron huy\u1ebft thanh d\u1eabn \u0111\u1ebfn gi\u1ea3m gi\u1eef natri, l\u00e0m t\u0103ng h\u1ec7 gi\u00e3n m\u1ea1ch kallikrein &#8211; kinin v\u00e0 c\u00f3 th\u1ec3 l\u00e0m thay \u0111\u1ed5i chuy\u1ec3n h\u00f3a prostanoid v\u00e0 \u1ee9c ch\u1ebf h\u1ec7 th\u1ea7n kinh giao c\u1ea3m. Enalapril c\u0169ng \u1ee9c ch\u1ebf ph\u00e2n h\u1ee7y bradykinin, m\u1ed9t ch\u1ea5t g\u00e2y gi\u00e3n m\u1ea1ch m\u1ea1nh.<\/p>\n<p>\u1ede b\u1ec7nh nh\u00e2n t\u0103ng huy\u1ebft \u00e1p, Enalapril l\u00e0m gi\u1ea3m huy\u1ebft \u00e1p b\u1eb1ng c\u00e1ch l\u00e0m gi\u1ea3m s\u1ee9c c\u1ea3n to\u00e0n b\u1ed9 ngo\u1ea1i vi k\u00e8m theo t\u0103ng nh\u1eb9 ho\u1eb7c kh\u00f4ng t\u0103ng t\u1ea7n s\u1ed1 tim, l\u01b0u l\u01b0\u1ee3ng t\u00e2m thu ho\u1eb7c l\u01b0u l\u01b0\u1ee3ng tim.<\/p>\n<p>Thu\u1ed1c g\u00e2y gi\u00e3n \u0111\u1ed9ng m\u1ea1ch v\u00e0 c\u00f3 th\u1ec3 c\u1ea3 t\u0129nh m\u1ea1ch. Enalapril th\u01b0\u1eddng l\u00e0m gi\u1ea3m huy\u1ebft \u00e1p t\u00e2m thu v\u00e0 t\u00e2m tr\u01b0\u01a1ng kho\u1ea3ng 10 &#8211; 15% \u1edf c\u1ea3 hai t\u01b0 th\u1ebf n\u1eb1m v\u00e0 ng\u1ed3i. H\u1ea1 huy\u1ebft \u00e1p th\u1ebf \u0111\u1ee9ng v\u00e0 nh\u1ecbp tim nhanh \u00edt khi x\u1ea3y ra, nh\u01b0ng th\u01b0\u1eddng hay g\u1eb7p h\u01a1n \u1edf ng\u01b0\u1eddi gi\u1ea3m natri m\u00e1u ho\u1eb7c gi\u1ea3m th\u1ec3 t\u00edch m\u00e1u.<\/p>\n<p>\u1ede b\u1ec7nh nh\u00e2n suy tim sung huy\u1ebft, Enalapril th\u01b0\u1eddng ph\u1ed1i h\u1ee3p v\u1edbi glycosid tim v\u00e0 thu\u1ed1c l\u1ee3i ti\u1ec3u, l\u00e0m gi\u1ea3m s\u1ee9c c\u1ea3n to\u00e0n b\u1ed9 ngo\u1ea1i vi, \u00e1p l\u1ef1c \u0111\u1ed9ng m\u1ea1ch ph\u1ed5i b\u00edt, k\u00edch th\u01b0\u1edbc tim, \u00e1p l\u1ef1c \u0111\u1ed9ng m\u1ea1ch trung b\u00ecnh v\u00e0 \u00e1p l\u1ef1c nh\u0129 ph\u1ea3i. Ch\u1ec9 s\u1ed1 tim, cung l\u01b0\u1ee3ng tim, th\u1ec3 t\u00edch t\u00e2m thu v\u00e0 dung n\u1ea1p g\u1eafng s\u1ee9c gia t\u0103ng. Enalapril gi\u1ea3m h\u1eadu g\u00e1nh b\u1ecb t\u0103ng cao. Ph\u00ec \u0111\u1ea1i th\u1ea5t tr\u00e1i gi\u1ea3m sau 2- 3 th\u00e1ng d\u00f9ng thu\u1ed1c \u1ee9c ch\u1ebf enzym chuy\u1ec3n angiotensin, v\u00ec angiotensin II l\u00e0 1 ch\u1ea5t k\u00edch th\u00edch m\u1ea1nh t\u0103ng tr\u01b0\u1edfng c\u01a1 tim.<\/p>\n<p>\u1ede b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng, Enalapril l\u00e0m gi\u1ea3m b\u00e0i ti\u1ebft protein &#8211; ni\u1ec7u. Enalapril c\u0169ng l\u00e0m t\u0103ng \u0111\u1ed9 nh\u1ea1y c\u1ea3m v\u1edbi insulin \u1edf b\u1ec7nh nh\u00e2n t\u0103ng huy\u1ebft \u00e1p b\u1ecb ho\u1eb7c kh\u00f4ng b\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng.<\/p>\n<p>Enalapril kh\u00f4ng l\u00e0m gi\u1ea3m chuy\u1ec3n h\u00f3alipid b\u1ea5t c\u1ee9 m\u1ee9c \u0111\u1ed9 n\u00e0o kh\u1ecfi tu\u1ea7n ho\u00e0n.<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>Enalapril l\u00e0 m\u1ed9t thu\u1ed1c \u1ee9c ch\u1ebf enzym chuy\u1ec3n angiotensin, c\u00f3 t\u00e1c d\u1ee5ng nh\u1edd enalaprilat l\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a enalapril sau khi u\u1ed1ng. Enalapril l\u00e0m gi\u1ea3m huy\u1ebft \u00e1p \u1edf ng\u01b0\u1eddi huy\u1ebft \u00e1p b\u00ecnh th\u01b0\u1eddng, ng\u01b0\u1eddi t\u0103ng huy\u1ebft \u00e1p, v\u00e0 c\u00f3 t\u00e1c d\u1ee5ng t\u1ed1t \u0111\u1ebfn huy\u1ebft \u0111\u1ed9ng \u1edf ng\u01b0\u1eddi suy tim sung huy\u1ebft, ch\u1ee7 y\u1ebfu do \u1ee9c ch\u1ebf h\u1ec7 renin &#8211; angiotensin &#8211; aldosteron.<\/p>\n<p>Enalapril ng\u0103n c\u1ea3n angiotensin I chuy\u1ec3n th\u00e0nh angiotensin II (ch\u1ea5t g\u00e2y co m\u1ea1ch m\u1ea1nh) nh\u1edd \u1ee9c ch\u1ebf enzym chuy\u1ec3n angiotensin (ACE). \u1ee8c ch\u1ebf ACE l\u00fac \u0111\u1ea7u l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 angiotensin II trong huy\u1ebft t\u01b0\u01a1ng v\u00e0 h\u1eadu qu\u1ea3 l\u00e0 huy\u1ebft \u00e1p c\u01a1 th\u1ec3 b\u1ecb gi\u1ea3m m\u1ed9t ph\u1ea7n do gi\u1ea3m co m\u1ea1ch. S\u1ef1 gi\u1ea3m angiotensin II n\u00e0y l\u00e0m ho\u1ea1t t\u00ednh renin trong huy\u1ebft t\u01b0\u01a1ng (PRA = plasma renin activity) t\u0103ng v\u00e0 l\u00e0m gi\u1ea3m ti\u1ebft aldosteron. T\u00e1c d\u1ee5ng gi\u1ea3m huy\u1ebft \u00e1p ban \u0111\u1ea7u c\u1ee7a enalapril t\u1ecf ra t\u1ef7 l\u1ec7 v\u1edbi \u1ee9c ch\u1ebf ACE trong m\u00e1u, nh\u01b0ng t\u00e1c d\u1ee5ng gi\u1ea3m huy\u1ebft \u00e1p c\u1ee7a thu\u1ed1c k\u00e9o d\u00e0i h\u01a1n so v\u1edbi gi\u1ea3m n\u1ed3ng \u0111\u1ed9 angiotensin II. C\u00f3 \u00fd ki\u1ebfn cho r\u1eb1ng t\u00e1c d\u1ee5ng gi\u1ea3m huy\u1ebft \u00e1p c\u1ee7a thu\u1ed1c \u1ee9c ch\u1ebf ACE c\u0169ng c\u00f3 th\u1ec3 m\u1ed9t ph\u1ea7n do t\u00e1c d\u1ee5ng t\u1ea1i ch\u1ed7 (nh\u01b0 \u1edf th\u00e0nh m\u1ea1ch m\u00e1u). B\u1eb1ng c\u00e1ch l\u00e0m gi\u1ea3m s\u1ea3n xu\u1ea5t angiotensin II t\u1ea1i ch\u1ed7, thu\u1ed1c \u1ee9c ch\u1ebf ACE c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m tr\u01b0\u01a1ng l\u1ef1c c\u1ee7a th\u00e0nh m\u1ea1ch b\u1eb1ng c\u00e1ch l\u00e0m gi\u1ea3m co m\u1ea1ch tr\u1ef1c ti\u1ebfp do angiotensin II v\u00e0\/ho\u1eb7c l\u00e0m t\u0103ng ho\u1ea1t t\u00ednh h\u1ec7 th\u1ea7n kinh giao c\u1ea3m do angiotensin II. Trong khi d\u00f9ng l\u00e2u d\u00e0i enalapril, n\u1ed3ng \u0111\u1ed9 angiotensin II trong huy\u1ebft t\u01b0\u01a1ng c\u00f3 th\u1ec3 tr\u1edf l\u1ea1i m\u1ee9c tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb, v\u00e0 \u1ee9c ch\u1ebf h\u1ec7 th\u1ed1ng renin-angiotensin \u1edf c\u00e1c m\u00f4 (nh\u01b0 \u1edf th\u00e0nh m\u1ea1ch, th\u1eadn) h\u01a1n l\u00e0 \u1edf m\u00e1u c\u00f3 th\u1ec3 l\u00e0 nh\u1eefng y\u1ebfu t\u1ed1 quy\u1ebft \u0111\u1ecbnh quan tr\u1ecdng h\u01a1n nhi\u1ec1u \u0111\u1ed1i v\u1edbi t\u00e1c d\u1ee5ng gi\u1ea3m huy\u1ebft \u00e1p c\u1ee7a thu\u1ed1c, \u0111\u1eb7c bi\u1ec7t khi d\u00f9ng l\u00e2u d\u00e0i.<\/p>\n<p><a href=\"https:\/\/www.youtube.com\/watch?v=F1Pl4DO5flA\"><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/a><\/p>\n<p><strong>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/strong><\/p>\n<p>H\u1ea5p thu: Sau khi u\u1ed1ng, kho\u1ea3ng 60% li\u1ec1u Enalapril \u0111\u01b0\u1ee3c h\u1ea5p thu qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a. N\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh c\u1ee7a thu\u1ed1c trong huy\u1ebft thanh \u0111\u1ea1t \u0111\u01b0\u1ee3c trong v\u00f2ng 0,5 &#8211; 1,5 gi\u1edd. T\u00e1c d\u1ee5ng huy\u1ebft \u0111\u1ed9ng h\u1ecdc k\u00e9o d\u00e0i kho\u1ea3ng 24 gi\u1edd. Th\u1ee9c \u0103n kh\u00f4ng \u1ea3nh h\u01b0\u1edfng t\u1edbi h\u1ea5p thu thu\u1ed1c.<\/p>\n<p>Ph\u00e2n b\u1ed1: Kho\u1ea3ng 50 &#8211; 60% Enalapril li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<p>Chuy\u1ec3n h\u00f3a: Sau khi h\u1ea5p thu, Enalapril \u0111\u01b0\u1ee3c th\u1ee7y ph\u00e2n nhi\u1ec1u \u1edf gan th\u00e0nh enalaprilat. N\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh c\u1ee7a enalaprilat trong huy\u1ebft thanh xu\u1ea5t hi\u1ec7n trong v\u00f2ng 3 &#8211; 4 gi\u1edd.<\/p>\n<p>Th\u1ea3i tr\u1eeb; Kho\u1ea3ng 60% li\u1ec1u u\u1ed1ng b\u00e0i ti\u1ebft v\u00e0o n\u01b0\u1edbc ti\u1ec3u \u1edf d\u1ea1ng enalaprilat v\u00e0 d\u1ea1ng kh\u00f4ng chuy\u1ec3n h\u00f3a, ph\u1ea7n c\u00f2n l\u1ea1i c\u1ee7a thu\u1ed1c \u0111\u00e0o th\u1ea3i theo ph\u00e2n. Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a thu\u1ed1c kho\u1ea3ng 11 gi\u1edd.<\/p>\n<p>Th\u1ea9m t\u00e1ch m\u00e1u v\u00e0 th\u1ea9m ph\u00e2n ph\u00fac m\u1ea1c c\u00f3 th\u1ec3 lo\u1ea1i Enalapril ra kh\u1ecfi tu\u1ea7n ho\u00e0n<\/p>\n<p><strong>5.3 Gi\u1ea3i th\u00edch: <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong>5.4 Thay th\u1ebf thu\u1ed1c : <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/strong><\/p>\n<p><strong>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/strong><\/p>\n<p>Lactose monohydrat, Tinh b\u1ed9t ng\u00f4, Natri croscarmellose, Tinh b\u1ed9t ti\u1ec1n gelatin h\u00f3a, Natri hydrocarbonat, Magnesi stearat.<\/p>\n<p><strong>6.2. T\u01b0\u01a1ng k\u1ef5 :<\/strong><\/p>\n<p>Kh\u00f4ng c\u00f3.<\/p>\n<p><strong>6.3. B\u1ea3o qu\u1ea3n: <\/strong><\/p>\n<p>B\u1ea3o qu\u1ea3n trong bao b\u00ec k\u00edn, n\u01a1i kh\u00f4. Nhi\u1ec7t \u0111\u1ed9 kh\u00f4ng qu\u00e1 30\u00b0C<\/p>\n<p><strong>6.4. Th\u00f4ng tin kh\u00e1c :<\/strong><\/p>\n<p>Kh\u00f4ng c\u00f3.<\/p>\n<p><strong>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/strong><\/p>\n<p>D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Enalapril Ph\u00e2n lo\u1ea1i: Thu\u1ed1c nh\u00f3m \u1ee9c ch\u1ebf enzym chuy\u1ec3n angiotensin.. Nh\u00f3m ph\u00e1p l\u00fd: Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine) M\u00e3 ATC (Anatomical Therapeutic Chemical): C09AA02. Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c: Renitec Bi\u1ec7t d\u01b0\u1ee3c: Hasitec, Enamigal H\u00e3ng s\u1ea3n xu\u1ea5t : C\u00f4ng ty [&hellip;]<\/p>\n","protected":false},"author":8612,"featured_media":22682,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[784],"class_list":["post-22680","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-enalapril"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/22680","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/8612"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=22680"}],"version-history":[{"count":4,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/22680\/revisions"}],"predecessor-version":[{"id":48532,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/22680\/revisions\/48532"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/22682"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=22680"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=22680"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=22680"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}