{"id":20602,"date":"2020-07-14T15:32:54","date_gmt":"2020-07-14T08:32:54","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=20602"},"modified":"2025-01-08T20:55:05","modified_gmt":"2025-01-08T13:55:05","slug":"desloratadine-ruradin","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/desloratadine-ruradin\/","title":{"rendered":"Desloratadine &#8211; Ruradin"},"content":{"rendered":"<p><strong>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: <\/strong><\/p>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <\/strong><a href=\"https:\/\/pharmog.com\/wp\/desloratadine\/\"><strong>Desloratadine<\/strong><\/a><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u1ed1c kh\u00e1ng histamin H1.<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>thu\u1ed1c kh\u00f4ng k\u00ea \u0111\u01a1n OTC \u2013 (Over the counter drugs)<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): R06AX27.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em><\/strong> <a href=\"https:\/\/pharmog.com\/wp\/desloratadine-aerius\/\">AERIUS<\/a><\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c:<\/em><\/strong> Ruradin<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: C\u00f4ng ty Roussel Vi\u1ec7t Nam.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng: <\/strong><\/p>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>Vi\u00ean n\u00e9n: 5 mg.<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>RURADIN<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean n\u00e9n ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Desloratadine<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>5 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"502\" height=\"399\" class=\"wp-image-20603\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/07\/word-image-183.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/07\/word-image-183.png 502w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/07\/word-image-183-300x238.png 300w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/07\/word-image-183-201x160.png 201w\" sizes=\"auto, (max-width: 502px) 100vw, 502px\" \/><\/p>\n<p><strong>3. Video by Pharmog:<\/strong><\/p>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe loading=\"lazy\" title=\"[Pharmog SS1 - T\u1eadp 06] - D\u01b0\u1ee3c l\u00fd v\u1ec1 thu\u1ed1c kh\u00e1ng Histamin H1\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/fAp4TM3XUKA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<p><strong>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng: <\/strong><\/p>\n<p><strong>4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>Desloratadin \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh gi\u1ea3m c\u00e1c tri\u1ec7u ch\u1ee9ng c\u00f3 li\u00ean quan \u0111\u1ebfn:<\/p>\n<p>Vi\u00eam m\u0169i d\u1ecb \u1ee9ng theo m\u00f9a, d\u1ecb \u1ee9ng quanh n\u0103m nh\u01b0 h\u1eaft h\u01a1i s\u1ed5 m\u0169i, ng\u1ee9a, ch\u1ea3y n\u01b0\u1edbc m\u1eaft v\u00e0 \u0111\u1ecf m\u1eaft<\/p>\n<p>M\u00e0y \u0111ay t\u1ef1 ph\u00e1t m\u1ea1n t\u00ednh.<\/p>\n<p><strong>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/strong><\/p>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p>Ruradin \u0111\u01b0\u1ee3c d\u00f9ng b\u1eb1ng \u0111\u01b0\u1eddng u\u1ed1ng.<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p>Ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em t\u1eeb 12 tu\u1ed5i tr\u1edf l\u00ean: 5 mg (1 vi\u00ean) x 1 l\u1ea7n\/ng\u00e0y.<\/p>\n<p>Tr\u1ebb em t\u1eeb 6 \u0111\u1ebfn 11 tu\u1ed5i: 2,5 mg (1\/2 vi\u00ean) x 1 l\u1ea7n\/ng\u00e0y. Tr\u1ebb nh\u1ecf h\u01a1n kh\u00f4ng s\u1eed d\u1ee5ng do qui c\u00e1ch vi\u00ean kh\u00f4ng t\u01b0\u01a1ng th\u00edch.<\/p>\n<p>Li\u1ec1u kh\u1edfi \u0111\u1ea7u ch\u1ec9 \u0111\u1ecbnh cho ng\u01b0\u1eddi l\u1edbn suy gan ho\u1eb7c th\u1eadn : 5 mg d\u00f9ng c\u00e1ch ng\u00e0y<\/p>\n<p><strong>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>Qu\u00e1 m\u1eabn v\u1edbi desloratadin, v\u1edbi b\u1ea5t c\u1ee9 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c ho\u1eb7c v\u1edbi loratadin.<\/p>\n<p><strong>4.4 Th\u1eadn tr\u1ecdng:<\/strong><\/p>\n<p>N\u00ean d\u00f9ng desloratadin th\u1eadn tr\u1ecdng trong tr\u01b0\u1eddng h\u1ee3p suy th\u1eadn v\u00e0 gan n\u1eb7ng.<\/p>\n<p>Kh\u00f4ng n\u00ean d\u00f9ng thu\u1ed1c cho b\u1ec7nh nh\u00e2n c\u00f3 nh\u1eefng v\u1ea5n \u0111\u1ec1 v\u1ec1 di truy\u1ec1n li\u00ean quan \u0111\u1ebfn kh\u00f4ng dung n\u1ea1p galactose, khi\u1ebfm khuy\u1ebft men Lapp lactase ho\u1eb7c r\u1ed1i lo\u1ea1n h\u1ea5p thu glucose \u2013 galactose (tr\u01b0\u1eddng h\u1ee3p t\u00e1 d\u01b0\u1ee3c l\u00e0 lactose).<\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>Trong nghi\u00ean c\u1ee9u \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c \u1edf b\u1ec7nh nh\u00e2n d\u00f9ng desloratadin, kh\u00f4ng x\u1ea3y ra tr\u01b0\u1eddng h\u1ee3p n\u00e0o nguy hi\u1ec3m. Tuy nhi\u00ean, n\u00ean th\u00f4ng b\u00e1o cho b\u1ec7nh nh\u00e2n bi\u1ebft r\u1ea5t hi\u1ebfm m\u1ed9t v\u00e0i ng\u01b0\u1eddi th\u1ea5y ch\u00f3ng m\u1eb7t, \u0111i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n<p><strong>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/strong><\/p>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: B1<\/p>\n<p>US FDA pregnancy category: C<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>Ch\u1ec9 s\u1eed d\u1ee5ng desloratadin trong th\u1eddi k\u1ef3 mang thai khi th\u1eadt c\u1ea7n thi\u1ebft.<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>Desloratadin qua s\u1eefa m\u1eb9, v\u00ec v\u1eady n\u00ean quy\u1ebft \u0111\u1ecbnh ng\u1eebng cho con b\u00fa ho\u1eb7c ng\u1eebng s\u1eed d\u1ee5ng desloratadin sau khi c\u00e2n nh\u1eafc t\u1ea7m quan tr\u1ecdng c\u1ee7a thu\u1ed1c \u0111\u1ed1i v\u1edbi ng\u01b0\u1eddi m\u1eb9.<\/p>\n<p><strong>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/strong><\/p>\n<p>T\u00e1c d\u1ee5ng ph\u1ee5 th\u01b0\u1eddng g\u1eb7p \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o nhi\u1ec1u h\u01a1n so v\u1edbi nh\u00f3m d\u00f9ng gi\u1ea3 d\u01b0\u1ee3c bao g\u1ed3m m\u1ec7t m\u1ecfi (1,2%), kh\u00f4 mi\u1ec7ng (0,8%) v\u00e0 \u0111au \u0111\u1ea7u (0,6%).<\/p>\n<p>T\u00e1c d\u1ee5ng ph\u1ee5 ph\u1ed5 bi\u1ebfn bao g\u1ed3m vi\u00eam h\u1ecdng, kh\u00f4 mi\u1ec7ng, nh\u1ee9c \u0111\u1ea7u, bu\u1ed3n n\u00f4n, m\u1ec7t m\u1ecfi, m\u1ea5t ng\u1ee7, ch\u00f3ng m\u1eb7t, th\u1ed1ng kinh, kh\u00f3 ti\u00eau v\u00e0 \u0111au c\u01a1.<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<p><strong>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/strong><\/p>\n<p>Ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c. V\u1edbi c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i nh\u1eb9, th\u01b0\u1eddng ch\u1ec9 c\u1ea7n ng\u1eebng thu\u1ed1c. Tr\u01b0\u1eddng h\u1ee3p m\u1eabn c\u1ea3m n\u1eb7ng ho\u1eb7c ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, c\u1ea7n ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 (gi\u1eef tho\u00e1ng kh\u00ed v\u00e0 d\u00f9ng epinephrin, th\u1edf oxygen, d\u00f9ng kh\u00e1ng histamin, corticoid&#8230;).<\/p>\n<p><strong>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/strong><\/p>\n<p>C\u00e1c thu\u1ed1c t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn men gan<\/p>\n<p>T\u01b0\u01a1ng t\u00e1c d\u01b0\u1ee3c \u0111\u1ed9ng c\u00f3 th\u1ec3 x\u1ea3y ra (t\u0103ng n\u1ed3ng \u0111\u1ed9 c\u1ee7a desloratadin v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh) khi d\u00f9ng desloratadin \u0111\u1ed3ng th\u1eddi v\u1edbi thu\u1ed1c t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn men gan (nh\u01b0 azithromycin, cimetidin, erythromycin, fluoxetin, ketoconazol). Kh\u00f4ng c\u00f3 nh\u1eefng thay \u0111\u1ed5i l\u00e2m s\u00e0ng quan tr\u1ecdng tr\u00ean \u0111i\u1ec7n t\u00e2m \u0111\u1ed3 ho\u1eb7c tr\u00ean nh\u1eefng th\u1eed nghi\u1ec7m \u0111\u00e1nh gi\u00e1, d\u1ea5u hi\u1ec7u nguy hi\u1ec3m hay v\u1ec1 t\u00e1c d\u1ee5ng ngo\u1ea1i \u00fd.<\/p>\n<p>N\u01b0\u1edbc b\u01b0\u1edfi: N\u01b0\u1edbc b\u01b0\u1edfi kh\u00f4ng l\u00e0m thay \u0111\u1ed5i d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a desloratadin<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/strong><\/p>\n<p>Trong tr\u01b0\u1eddng h\u1ee3p qu\u00e1 li\u1ec1u, xem x\u00e9t nh\u1eefng bi\u1ec7n ph\u00e1p chu\u1ea9n \u0111\u1ec3 lo\u1ea1i b\u1ecf ph\u1ea7n ho\u1ea1t ch\u1ea5t ch\u01b0a \u0111\u01b0\u1ee3c h\u1ea5p thu. Khuy\u1ebfn c\u00e1o \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng v\u00e0 \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3.<\/p>\n<p>D\u1ef1a tr\u00ean nh\u1eefng th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng khi d\u00f9ng li\u1ec1u l\u00ean \u0111\u1ebfn 45 mg desloratadin (g\u1ea5p 9 l\u1ea7n li\u1ec1u d\u00f9ng), kh\u00f4ng quan s\u00e1t th\u1ea5y nh\u1eefng t\u00e1c d\u1ee5ng l\u00e2m s\u00e0ng c\u00f3 li\u00ean quan. Desloratadin kh\u00f4ng b\u1ecb lo\u1ea1i tr\u1eeb b\u1eb1ng th\u1ea9m t\u00e1ch m\u00e1u nh\u01b0ng ch\u01b0a bi\u1ebft c\u00f3 b\u1ecb lo\u1ea1i tr\u1eeb qua th\u1ea9m t\u00e1ch m\u00e0ng b\u1ee5ng kh\u00f4ng.<\/p>\n<p><strong>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/strong><\/p>\n<p><strong>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/strong><\/p>\n<p>Desloratadin l\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a descarboethoxy c\u00f3 ho\u1ea1t t\u00ednh c\u1ee7a loratadin v\u00e0 l\u00e0 m\u1ed9t thu\u1ed1c kh\u00e1ng histamin 3 v\u00f2ng c\u00f3 t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i. Thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng \u0111\u1ed1i kh\u00e1ng ch\u1ecdn l\u1ecdc \u0111\u1eb7c hi\u1ec7u tr\u00ean th\u1ee5 th\u1ec3 H1, \u1edf ngo\u1ea1i bi\u00ean. B\u1eb1ng ch\u1ee9ng th\u1ef1c nghi\u1ec7m cho th\u1ea5y desloratadin ng\u0103n ch\u1eb7n s\u1ef1 ph\u00f3ng th\u00edch histamin t\u1eeb t\u1ebf b\u00e0o mast c\u1ee7a ng\u01b0\u1eddi. Do desloratadin kh\u00f3 qua h\u00e0ng r\u00e0o m\u00e1u n\u00e3o, n\u00ean thu\u1ed1c \u0111\u01b0\u1ee3c x\u1ebfp v\u00e0o nh\u00f3m thu\u1ed1c kh\u00e1ng histamin \u201dkh\u00f4ng an th\u1ea7n\u201d ho\u1eb7c thu\u1ed1c kh\u00e1ng histamin th\u1ebf h\u1ec7 hai.<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>Desloratadin l\u00e0 m\u1ed9t ch\u1ea5t kh\u00e1ng histamin 3 v\u00f2ng c\u00f3 t\u00e1c d\u1ee5ng k\u00e9o d\u00e0i v\u1edbi t\u00e1c \u0111\u1ed9ng kh\u00e1ng histamin ch\u1ecdn l\u1ecdc tr\u00ean th\u1ee5 th\u1ec3 H<sub>1<\/sub>. S\u1ed1 li\u1ec7u v\u1ec1 s\u1ef1 v\u1edbi g\u1eafn th\u1ee5 th\u1ec3 cho th\u1ea5y \u1edf n\u1ed3ng \u0111\u1ed9 2 &#8211; 3mg\/ml (7nanomol), desloratadin th\u1ec3 hi\u1ec7n t\u01b0\u01a1ng t\u00e1c \u0111i\u1ec3n h\u00ecnh v\u1edbi th\u1ee5 th\u1ec3 H<sub>1<\/sub>\u00a0\u1edf ng\u01b0\u1eddi. Desloratadin \u1ee9c ch\u1ebf s\u1ef1 gi\u1ea3i ph\u00f3ng histamin t\u1eeb c\u00e1c d\u01b0\u1ee1ng b\u00e0o trong th\u1eed nghi\u1ec7m\u00a0<em>in vitro.\u00a0<\/em>Desloratidin c\u00f3 t\u00e1c \u0111\u1ed9ng k\u00e9o d\u00e0i v\u00e0 kh\u00f4ng g\u00e2y bu\u1ed3n ng\u1ee7 do n\u00f3 kh\u00f4ng d\u1ec5 di qua h\u00e0ng r\u00e0o m\u00e1u n\u00e3o.<\/p>\n<p><a href=\"https:\/\/www.youtube.com\/watch?v=fAp4TM3XUKA\"><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/a><\/p>\n<p><strong>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/strong><\/p>\n<p>H\u1ea5p thu: Sau li\u1ec1u u\u1ed1ng desloratadin 5 mg x 1 l\u1ea7n\/ng\u00e0y trong 10 ng\u00e0y tr\u00ean ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n kh\u1ecfe m\u1ea1nh, th\u1eddi gian trung b\u00ecnh \u0111\u1ec3 \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 thu\u1ed1c t\u1ed1i \u0111a trong huy\u1ebft t\u01b0\u01a1ng (Tmax) kho\u1ea3ng 3 gi\u1edd v\u00e0 n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trung b\u00ecnh trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh (Cmax) l\u00e0 4 ng\/ml v\u00e0 di\u1ec7n t\u00edch d\u01b0\u1edbi \u0111\u01b0\u1eddng cong v\u1ec1 n\u1ed3ng \u0111\u1ed9 &#8211; th\u1eddi gian ( AUC) l\u00e0 56,9 ng.gi\u1edd\/ml. Th\u1ee9c \u0103n v\u00e0 n\u01b0\u1edbc b\u01b0\u1edfi kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn sinh kh\u1ea3 d\u1ee5ng (Cmax v\u00e0 AUC) c\u1ee7a desloratadin.<\/p>\n<p>Ph\u00e2n b\u1ed1: Desloratadin v\u00e0 3 \u2013 hydroxydesloratadin g\u1eafn k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng l\u1ea7n<\/p>\n<p>l\u01b0\u1ee3t l\u00e0 82 \u2013 87% v\u00e0 85 \u2013 89%. S\u1ef1 g\u1eafn k\u1ebft v\u00e0o protein c\u1ee7a desloratadin v\u00e0 3 \u2013 hydroxydesloratadin kh\u00f4ng thay \u0111\u1ed5i tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn.<\/p>\n<p>Chuy\u1ec3n h\u00f3a: Desloratadin (m\u1ed9t ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh c\u1ee7a loratadin) \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a m\u1ea1nh th\u00e0nh ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh 3 \u2013 hydroxydesloratadin, sau \u0111\u00f3 s\u1ebd b\u1ecb glucuronid h\u00f3a. C\u00e1c enzyme ch\u1ecbu tr\u00e1ch nhi\u1ec7m cho s\u1ef1 t\u1ea1o th\u00e0nh 3 \u2013 hydroxydesloratadin ch\u01b0a x\u00e1c \u0111\u1ecbnh.<\/p>\n<p>Th\u1ea3i tr\u1eeb: Th\u1eddi gian b\u00e1n th\u1ea3i trung b\u00ecnh c\u1ee7a desloratadin kho\u1ea3ng 27 gi\u1edd. C\u00e1c gi\u00e1 tr\u1ecb Cmax v\u00e0 AUC t\u0103ng t\u1ec9 l\u1ec7 theo li\u1ec1u u\u1ed1ng duy nh\u1ea5t trong kho\u1ea3ng t\u1eeb 5 \u2013 20 mg. M\u1ee9c \u0111\u1ed9 t\u00edch l\u0169y sau 14 ng\u00e0y d\u00f9ng thu\u1ed1c t\u01b0\u01a1ng \u1ee9ng v\u1edbi th\u1eddi gian b\u00e1n th\u1ea3i v\u00e0 t\u1ea7n s\u1ed1 li\u1ec1u d\u00f9ng.<\/p>\n<p><strong>5.3 Gi\u1ea3i th\u00edch: <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong>5.4 Thay th\u1ebf thu\u1ed1c : <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/strong><\/p>\n<p><strong>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/strong><\/p>\n<p>Microcystallin cellulose, starch 1500, natri croscarmellose, PEG 6000, crospovidon, natri starch glycolat, magnesi stearat, HPMC, titan dioxyd, tween 80, ready lycoat white, b\u1ed9t talc<\/p>\n<p><strong>6.2. T\u01b0\u01a1ng k\u1ef5 :<\/strong><\/p>\n<p>Kh\u00f4ng \u00e1p d\u1ee5ng.<\/p>\n<p><strong>6.3. B\u1ea3o qu\u1ea3n: <\/strong><\/p>\n<p>N\u01a1i kh\u00f4, m\u00e1t (d\u01b0\u1edbi 30\u00b0C). Tr\u00e1nh \u00e1nh s\u00e1ng.<\/p>\n<p><strong>6.4. Th\u00f4ng tin kh\u00e1c :<\/strong><\/p>\n<p>Kh\u00f4ng c\u00f3.<\/p>\n<p><strong>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/strong><\/p>\n<p>D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n","protected":false},"excerpt":{"rendered":"<p>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Desloratadine Ph\u00e2n lo\u1ea1i: Thu\u1ed1c kh\u00e1ng histamin H1. Nh\u00f3m ph\u00e1p l\u00fd: thu\u1ed1c kh\u00f4ng k\u00ea \u0111\u01a1n OTC \u2013 (Over the counter drugs) M\u00e3 ATC (Anatomical Therapeutic Chemical): R06AX27. Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c: AERIUS Bi\u1ec7t d\u01b0\u1ee3c: Ruradin H\u00e3ng s\u1ea3n xu\u1ea5t : C\u00f4ng ty Roussel Vi\u1ec7t Nam. 2. D\u1ea1ng b\u00e0o [&hellip;]<\/p>\n","protected":false},"author":8612,"featured_media":20603,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[680],"class_list":["post-20602","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-desloratadine"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/20602","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/8612"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=20602"}],"version-history":[{"count":3,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/20602\/revisions"}],"predecessor-version":[{"id":49267,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/20602\/revisions\/49267"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/20603"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=20602"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=20602"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=20602"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}