{"id":20133,"date":"2020-07-05T10:37:34","date_gmt":"2020-07-05T03:37:34","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=20133"},"modified":"2025-01-08T20:55:39","modified_gmt":"2025-01-08T13:55:39","slug":"donepezil-rizax","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/donepezil-rizax\/","title":{"rendered":"Donepezil &#8211; Rizax"},"content":{"rendered":"<p><strong>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: <\/strong><\/p>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <\/strong><a href=\"https:\/\/pharmog.com\/wp\/donepezil\/\"><strong>Donepezil hydrochloride<\/strong><\/a><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u1ed1c \u1ee9c ch\u1ebf acetylcholinesterase c\u00f3 th\u1ec3 h\u1ed3i ph\u1ee5c (t\u00e1c d\u1ee5ng trung t\u00e2m).<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): N06DA02.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em><\/strong><\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c:<\/em><\/strong> Rizax<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m \u0110\u1ea1t Vi Ph\u00fa<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng: <\/strong><\/p>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>Vi\u00ean n\u00e9n: 5 mg ,10mg<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>RIZAX<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean n\u00e9n c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Donepezil hydrochloride<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>5 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"406\" height=\"323\" class=\"wp-image-20134\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/07\/word-image-13.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/07\/word-image-13.png 406w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/07\/word-image-13-300x239.png 300w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/07\/word-image-13-201x160.png 201w\" sizes=\"auto, (max-width: 406px) 100vw, 406px\" \/><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>RIZAX-10<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean n\u00e9n c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Donepezil hydrochloride<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>10 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"523\" height=\"340\" class=\"wp-image-20135\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/07\/word-image-14.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/07\/word-image-14.png 523w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/07\/word-image-14-300x195.png 300w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/07\/word-image-14-246x160.png 246w\" sizes=\"auto, (max-width: 523px) 100vw, 523px\" \/><\/p>\n<p><strong>3. Video by Pharmog:<\/strong><\/p>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<p><strong>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng: <\/strong><\/p>\n<p><strong>4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>Donepezil \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng sa s\u00fat tr\u00ed tu\u1ec7 c\u1ee7a b\u1ec7nh Alzheimer t\u1eeb m\u1ee9c \u0111\u1ed9 nh\u1eb9 \u0111\u1ebfn m\u1ee9c \u0111\u1ed9 n\u1eb7ng v\u1eeba ph\u1ea3i.<\/p>\n<p><strong>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/strong><\/p>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p>U\u1ed1ng v\u00e0o bu\u1ed5i t\u1ed1i tr\u01b0\u1edbc khi ngh\u1ec9 ng\u01a1i<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p><em>Ng\u01b0\u1eddi l\u1edbn v\u00e0 ng\u01b0\u1eddi cao tu\u1ed5i:<\/em><\/p>\n<p>Kh\u1edfi \u0111\u1ea7u: U\u1ed1ng 5 mg\/ng\u00e0y v\u00e0o bu\u1ed5i t\u1ed1i tr\u01b0\u1edbc khi ngh\u1ec9 ng\u01a1i. Duy tr\u00ec li\u1ec1u n\u00e0y trong \u00edt nh\u1ea5t 1 th\u00e1ng \u0111\u1ec3 donepezil \u0111\u1ea1t tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh v\u00e0 th\u1ea5y \u0111\u01b0\u1ee3c \u0111\u00e1p \u1ee9ng l\u00e2m s\u00e0ng.<\/p>\n<p>Sau 1 th\u00e1ng, c\u00f3 th\u1ec3 t\u0103ng li\u1ec1u d\u00f9ng l\u00ean 10 mg\/ng\u00e0y, u\u1ed1ng 1 l\u1ea7n v\u00e0o bu\u1ed5i t\u1ed1i tr\u01b0\u1edbc khi ngh\u1ec9 ng\u01a1i. Kh\u00f4ng d\u00f9ng li\u1ec1u cao h\u01a1n 10 mg\/ng\u00e0y v\u00ec ch\u01b0a c\u00f3 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng.<\/p>\n<p>Ng\u01b0ng s\u1eed d\u1ee5ng thu\u1ed1c n\u1ebfu kh\u00f4ng c\u00f2n th\u1ea5y hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p><em>Suy gan, suy th\u1eadn:<\/em><\/p>\n<p>Suy th\u1eadn: Kh\u00f4ng c\u1ea7n thi\u1ebft \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u d\u00f9ng.<\/p>\n<p>Suy gan m\u1ee9c \u0111\u1ed9 nh\u1eb9 v\u00e0 trung b\u00ecnh: \u0110i\u1ec1u ch\u1ec9nh li\u1ec1u d\u00f9ng t\u00f9y theo m\u1ee9c \u0111\u1ed9 dung n\u1ea1p c\u1ee7a t\u1eebng b\u1ec7nh nh\u00e2n. Kh\u00f4ng c\u00f3 s\u1ed1 li\u1ec7u \u0111\u1ed1i v\u1edbi suy gan n\u1eb7ng.<\/p>\n<p><em>Tr\u1ebb em<\/em>: Kh\u00f4ng s\u1eed d\u1ee5ng thu\u1ed1c n\u00e0y cho tr\u1ebb em.<\/p>\n<p><strong>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>Qu\u00e1 m\u1eabn v\u1edbi b\u1ea5t c\u1ee9 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p><strong>4.4 Th\u1eadn tr\u1ecdng:<\/strong><\/p>\n<p>Ch\u1ec9 s\u1eed d\u1ee5ng donepezil cho c\u00e1c b\u1ec7nh nh\u00e2n sa s\u00fat tr\u00ed tu\u1ec7 do b\u1ec7nh Alzheimer. Ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u tr\u00ean c\u00e1c b\u1ec7nh gi\u1ea3m tr\u00ed nh\u1edb kh\u00e1c.<\/p>\n<p>G\u00e2y m\u00ea: Ch\u1ea5t \u1ee9c ch\u1ebf cholinesteraz l\u00e0m t\u0103ng t\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c gi\u00e3n c\u01a1 lo\u1ea1i succinylcholin.<\/p>\n<p>Tim m\u1ea1ch: Ch\u1ea5t \u1ee9c ch\u1ebf cholinesteraz c\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn nh\u1ecbp tim.<\/p>\n<p>\u0110\u01b0\u1eddng ti\u00eau h\u00f3a: B\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed lo\u00e9t d\u1ea1 d\u00e0y ho\u1eb7c b\u1ec7nh nh\u00e2n \u0111ang s\u1eed d\u1ee5ng thu\u1ed1c kh\u00e1ng vi\u00eam kh\u00f4ng steroid: t\u0103ng nguy c\u01a1 lo\u00e9t d\u1ea1 d\u00e0y.<\/p>\n<p>B\u1ec7nh th\u1ea7n kinh: C\u00e1c thu\u1ed1c gi\u1ed1ng cholin \u0111\u01b0\u1ee3c cho l\u00e0 c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y c\u00e1c c\u01a1n \u0111\u1ed9ng kinh.<\/p>\n<p>B\u1ec7nh ph\u1ed5i: N\u00ean c\u1ea9n th\u1eadn khi k\u00ea \u0111\u01a1n ch\u1ea5t \u1ee9c ch\u1ebf cholinesteraz cho c\u00e1c b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed hen suy\u1ec5n ho\u1eb7c c\u00f3 b\u1ec7nh ngh\u1ebdn ph\u1ed5i.<\/p>\n<p>Suy gan n\u1eb7ng: Kh\u00f4ng c\u00f3 s\u1ed1 li\u1ec7u v\u1ec1 b\u1ec7nh nh\u00e2n suy gan n\u1eb7ng.<\/p>\n<p>\u0110\u1ec3 xa t\u1ea7m tay tr\u1ebb em.<\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>N\u00ean th\u1eadn tr\u1ecdng khi l\u00e1i xe ho\u1eb7c v\u1eadn h\u00e0nh m\u00e1y m\u00f3c nguy hi\u1ec3m, ph\u1ee9c t\u1ea1p.<\/p>\n<p><strong>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/strong><\/p>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: B3<\/p>\n<p>US FDA pregnancy category: C<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>Kh\u00f4ng c\u00f3 s\u1ed1 li\u1ec7u v\u1ec1 s\u1eed d\u1ee5ng donepezil \u1edf ph\u1ee5 n\u1eef c\u00f3 thai. V\u00ec th\u1ebf ch\u1ec9 s\u1eed d\u1ee5ng trong thai k\u1ef3 khi th\u1eadt s\u1ef1 c\u1ea7n thi\u1ebft.<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>Donepezil \u0111\u01b0\u1ee3c ti\u1ebft v\u00e0o s\u1eefa chu\u1ed9t. Kh\u00f4ng c\u00f3 nghi\u00ean c\u1ee9u tr\u00ean ph\u1ee5 n\u1eef cho con b\u00fa. V\u00ec th\u1ebf kh\u00f4ng n\u00ean cho con b\u00fa khi s\u1eed d\u1ee5ng donepezil.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/strong><\/p>\n<p>T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n ph\u1ed5 bi\u1ebfn c\u1ee7a thu\u1ed1c \u1ee9c ch\u1ebf acetylcholinesterase nh\u01b0 donezepil bao g\u1ed3m: bu\u1ed3n n\u00f4n, n\u00f4n, ch\u00e1n \u0103n, ti\u00eau ch\u1ea3y, m\u1ec7t m\u1ecfi, ch\u00f3ng m\u1eb7t. C\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n th\u00f4ng th\u01b0\u1eddng kh\u00e1c bao g\u1ed3m: \u0111au b\u1ee5ng, kh\u00f3 ti\u00eau, ph\u00e1t ban, ng\u1ee9a, \u0111au \u0111\u1ea7u, ng\u1ee7 g\u00e0, co r\u00fat c\u01a1, m\u1ea5t ng\u1ee7, to\u00e1t m\u00f4 h\u00f4i, run v\u00e0 ng\u1ea5t x\u1ec9u; vi\u00eam \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p tr\u00ean, vi\u00eam \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn. Hi\u1ebfm khi x\u1ea3y ra \u0111au th\u1eaft ng\u1ef1c, block xoang nh\u0129 v\u00e0 block nh\u0129 th\u1ea5t, ch\u1eadm nh\u1ecbp tim, lo\u00e9t d\u1ea1 d\u00e0y, xu\u1ea5t huy\u1ebft ti\u00eau ho\u00e1, tri\u1ec7u ch\u1ee9ng ngo\u1ea1i th\u00e1p, v\u00e0 \u0111\u1ed9ng kinh. R\u1ed1i lo\u1ea1n t\u00e2m th\u1ea7n, bao g\u1ed3m tr\u1ea7m c\u1ea3m, \u1ea3o gi\u00e1c, k\u00edch \u0111\u1ed9ng, h\u00e0nh vi hung h\u0103ng, v\u00e0 nh\u1eb1m l\u1eabn c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o. C\u00f3 th\u1ec3 g\u00e2y b\u00ed ti\u1ec3u. T\u0103ng nh\u1eb9 creatine kinase huy\u1ebft thanh c\u0169ng \u0111\u00e3 x\u1ea3y ra khi d\u00f9ng donepezil. T\u0103ng men gan \u0111\u00e3 x\u1ea3y ra khi d\u00f9ng c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf acetylcholinesterase. S\u1eed d\u1ee5ng thu\u1ed1c \u1ee9c ch\u1ebf acetylcholinesterase c\u00f3 th\u1ec3 g\u00e2y gi\u1ea3m c\u00e2n, n\u00ean c\u1ea7n theo d\u00f5i c\u00e2n n\u1eb7ng trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb. S\u1eed d\u1ee5ng qu\u00e1 li\u1ec1u thu\u1ed1c \u1ee9c ch\u1ebf acetylcholinesterase c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn c\u01a1n cholinergic.<\/p>\n<p>\u1ea2nh h\u01b0\u1edfng l\u00ean h\u1ec7 tim m\u1ea1ch: Thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y lo\u1ea1n nh\u1ecbp tim nh\u01b0: nh\u1ecbp tim ch\u1eadm, block nh\u0129 th\u1ea5t, block b\u00f3 nh\u00e1nh, ng\u1ea5t xiu&#8230; Thu\u1ed1c c\u0169ng c\u00f3 th\u00e9 d\u1eabn \u0111\u1ebfn nh\u1ed3i m\u00e1u c\u01a1 t\u1ec9m v\u00e0 ng\u1eebng tim. H\u1ea7u h\u1ebft b\u1ec7nh nh\u00e2n \u0111\u1ec1u ph\u1ee5c h\u1ed3i sau khi ng\u1eebng thu\u1ed1c ho\u1eb7c gi\u1ea3m li\u1ec1u thu\u1ed1c, tuy nhi\u00ean c\u00f3 nhi\u1ec1u tr\u01b0\u1eddng h\u1ee3p ph\u1ea3i nh\u1eadp vi\u1ec7n v\u00e0 m\u1ed9t s\u1ed1 ph\u1ea3i d\u00f9ng m\u00e1y t\u1ea1o nh\u1ecbp tim.<\/p>\n<p>\u1ea2nh h\u01b0\u1edfng l\u00ean h\u1ec7 th\u1ea7n kinh: \u0110au ch\u00e2n khi b\u1ea5t \u0111\u1ed9ng (ch\u00e2n b\u1ed3n ch\u1ed3n), l\u1ea7m b\u1eb1m, n\u00f3i l\u1eafp b\u1eafp xu\u1ea5t hi\u1ec7n \u1edf ng\u01b0\u1eddi l\u1edbn tudi khi t\u0103ng li\u1ec1u donepezil l\u00ean 10 mg\/ ng\u00e0y. C\u00e1c tri\u1ec7u ch\u1ee9ng tr\u00ean h\u1ed3i ph\u1ee5c khi ng\u1eebng thu\u1ed1c v\u00e0 xu\u1ea5t hi\u1ec7n tr\u1edf l\u1ea1i khi s\u1eed d\u1ee5ng l\u1ea1i thu\u1ed1c.<\/p>\n<p>\u1ea2nh h\u01b0\u1edfng l\u00ean \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u: Ti\u1ec3u kh\u00f4ng t\u1ef1 ch\u1ee7 c\u00f3 th\u1ec3 x\u1ea3y ra khi s\u1eed d\u1ee5ng donepezil.<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<p><strong>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/strong><\/p>\n<p>Trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p x\u1ea3y ra \u1ea3o gi\u00e1c, t\u00ecnh tr\u1ea1ng k\u00edch \u0111\u1ed9ng v\u00e0 h\u00e0nh vi hung h\u0103ng, c\u1ea7n gi\u1ea3m li\u1ec1u ho\u1eb7c ng\u1eebng \u0111i\u1ec1u tr\u1ecb v\u1edbi donepezil. Trong tr\u01b0\u1eddng h\u1ee3p r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng gan kh\u00f4ng r\u00f5 nguy\u00ean nh\u00e2n, n\u00ean c\u00e2n nh\u1eafc vi\u1ec7c ng\u1eebng \u0111i\u1ec1u tr\u1ecb v\u1edbi donepezil.<\/p>\n<p><strong>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/strong><\/p>\n<p>Ketoconazol, quinidin, itraconazol, erythromycin, fluoxetin \u1ee9c ch\u1ebf s\u1ef1 chuy\u1ec3n h\u00f3a c\u1ee7a donepezil v\u00e0 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 c\u1ee7a donepezil.<\/p>\n<p>C\u00e1c ch\u1ea5t c\u1ea3m \u1ee9ng enzym nh\u01b0 rifampicin, phenytoin, carbamazepin v\u00e0 r\u01b0\u1ee3u c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 c\u1ee7a donepezil.<\/p>\n<p>Donepezil c\u00f3 t\u00e1c \u0111\u1ed9ng hi\u1ec7p l\u1ef1c v\u1edbi c\u00e1c thu\u1ed1c nh\u01b0 succinylcholin, thu\u1ed1c ch\u1eb9n th\u1ea7n kinh c\u01a1, thu\u1ed1c cholinergic, thu\u1ed1c ch\u1eb9n beta tr\u00ean s\u1ef1 co th\u1eaft c\u1ee7a c\u01a1 tim.<\/p>\n<p><strong>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/strong><\/p>\n<p>D\u00f9ng qu\u00e1 li\u1ec1u thu\u1ed1c \u1ee9c ch\u1ebf cholinesteraz c\u00f3 c\u00e1c bi\u1ec3u hi\u1ec7n tr\u1ea7m tr\u1ecdng nh\u01b0 bu\u1ed3n n\u00f4n, \u00f3i m\u1eeda, ti\u1ebft n\u01b0\u1edbc b\u1ecdt, ra m\u1ed3 h\u00f4i, nh\u1ecbp tim ch\u1eadm, h\u1ea1 huy\u1ebft \u00e1p, suy h\u00f4 h\u1ea5p, tr\u1ee5y tu\u1ea7n ho\u00e0n v\u00e0 co gi\u1eadt. Y\u1ebfu c\u01a1 c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn t\u1eed vong n\u1ebfu c\u01a1 h\u00f4 h\u1ea5p b\u1ecb y\u1ebfu.<\/p>\n<p>Khi d\u00f9ng qu\u00e1 li\u1ec1u, \u00e1p d\u1ee5ng c\u00e1c bi\u1ec7n ph\u00e1p \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3.<\/p>\n<p>C\u00f3 th\u1ec3 d\u00f9ng Atropin \u0111\u1ec3 gi\u1ea3i \u0111\u1ed9c: b\u1eaft \u0111\u1ea7u ti\u00eam t\u0129nh m\u1ea1ch 1 &#8211; 2 mg Atropin sulfat. C\u00e1c li\u1ec1u d\u00f9ng ti\u1ebfp theo t\u00f9y theo \u0111\u00e1p \u1ee9ng l\u00e2m s\u00e0ng.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/strong><\/p>\n<p><strong>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/strong><\/p>\n<p>Donepezil l\u00e0 thu\u1ed1c ch\u1ed1ng sa s\u00fat tr\u00ed tu\u1ec7, kh\u00e1ng cholinesteraz.<\/p>\n<p>Donepezil l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf \u0111\u1eb7c hi\u1ec7u v\u00e0 thu\u1eadn ngh\u1ecbch \u0111\u1ed1i v\u1edbi enzym acetylcholinesteraz. Acetylcholinesteraz l\u00e0 lo\u1ea1i cholinesteraz ch\u1ee7 y\u1ebfu trong n\u00e3o.<\/p>\n<p>In vitro, donepezil c\u00f3 t\u00e1c \u0111\u1ed9ng \u1ee9c ch\u1ebf acetylcholinesteraz m\u1ea1nh g\u1ea5p 1000 l\u1ea7n so v\u1edbi \u1ee9c ch\u1ebf butyrylcholinesteraz. Butyrylcholinesteraz l\u00e0 enzym hi\u1ec7n di\u1ec7n ch\u1ee7 y\u1ebfu \u1edf ngo\u00e0i h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>Thu\u1ed1c l\u00e0 m\u1ed9t ch\u1ea5t \u0111\u1ed1i kh\u00e1ng cholinesterase g\u1eafn thu\u1eadn ngh\u1ecbch v\u00e0o cholinesterase (nh\u01b0 acetylcholinesterase) v\u00e0 l\u00e0m b\u1ea5t ho\u1ea1t ch\u1ea5t n\u00e0y v\u00e0 nh\u01b0 v\u1eady \u1ee9c ch\u1ebf s\u1ef1 th\u1ee7y ph\u00e2n c\u1ee7a acetylcholin. \u0110i\u1ec1u n\u00e0y l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 acetylcholin \u1edf c\u00e1c synap cholinergic. Ho\u1ea1t t\u00ednh kh\u00e1ng acetylcholinesterase c\u1ee7a donepezil t\u01b0\u01a1ng \u0111\u1ed1i \u0111\u1eb7c tr\u01b0ng \u0111\u1ed1i v\u1edbi acetylcholinesterase \u1edf n\u00e3o so v\u1edbi s\u1ef1 \u1ee9c ch\u1ebf c\u1ee7a butyrylcholinesterase \u1edf c\u00e1c m\u00f4 ngo\u1ea1i bi\u00ean.<\/p>\n<p>S\u1ef1 thi\u1ebfu h\u1ee5t acetylcholin do m\u1ea5t ch\u1ecdn l\u1ecdc c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh cholinergic \u1edf v\u1ecf n\u00e3o, th\u00f9y tr\u00e1n, th\u00f9y \u0111\u1ec9nh, th\u00f9y th\u00e1i d\u01b0\u01a1ng, nh\u00e2n tr\u00e1m v\u00e0 h\u1ed3i h\u1ea3i m\u00e3, v\u00e0 c\u0169ng t\u1ea1i c\u00e1c h\u1ea1ch n\u1ec1n v\u00e0 h\u1ea1 kh\u00e2u n\u00e3o \u0111\u01b0\u1ee3c th\u1eeba nh\u1eadn l\u00e0 m\u1ed9t trong c\u00e1c \u0111\u1eb7c tr\u01b0ng sinh l\u00fd b\u1ec7nh h\u1ecdc \u0111\u1ea7u ti\u00ean c\u1ee7a b\u1ec7nh Alzheimer l\u00e0m m\u1ea5t tr\u00ed nh\u1edb v\u00e0 thi\u1ebfu h\u1ee5t nh\u1eadn th\u1ee9c. V\u00ec v\u1ecf n\u00e3o thi\u1ebfu h\u1ee5t ch\u1ea5t d\u1eabn truy\u1ec1n th\u1ea7n kinh n\u00e0y \u0111\u00e3 gi\u1ea3i th\u00edch \u0111\u01b0\u1ee3c m\u1ed9t s\u1ed1 bi\u1ec3u hi\u1ec7n l\u00e2m s\u00e0ng c\u1ee7a s\u1ef1 sa s\u00fat tr\u00ed tu\u1ec7 nh\u1eb9 v\u00e0 v\u1eeba, n\u00ean vi\u1ec7c t\u0103ng c\u01b0\u1eddng ch\u1ee9c n\u0103ng cholinergic b\u1eb1ng m\u1ed9t thu\u1ed1c \u1ee9c ch\u1ebf acetylcholinesterase nh\u01b0 tacrin ho\u1eb7c donepezil l\u00e0 m\u1ed9t trong c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb. V\u00ec nhi\u1ec1u h\u1ec7 th\u1ed1ng t\u1ebf b\u00e0o th\u1ea7n kinh trung t\u00e2m cu\u1ed1i c\u00f9ng \u0111i \u0111\u1ebfn tho\u00e1i h\u00f3a r\u1ed9ng \u1edf b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh Alzheimer, n\u00ean v\u1ec1 l\u00fd thuy\u1ebft, hi\u1ec7u l\u1ef1c c\u1ee7a c\u00e1c thu\u1ed1c kh\u00e1ng cholinesterase c\u00f3 th\u1ec3 gi\u1ea3m s\u00fat khi b\u1ec7nh ti\u1ebfn tri\u1ec3n v\u00e0 khi c\u00f2n \u00edt t\u1ebf b\u00e0o th\u1ea7n kinh cholinergic ho\u1ea1t \u0111\u1ed9ng.<\/p>\n<p><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/p>\n<p><strong>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/strong><\/p>\n<p>H\u1ea5p thu: N\u1ed3ng \u0111\u1ed9 t\u1ed1i \u0111a trong huy\u1ebft t\u01b0\u01a1ng \u0111\u1ea1t \u0111\u01b0\u1ee3c kho\u1ea3ng 3 &#8211; 4 gi\u1edd sau khi u\u1ed1ng thu\u1ed1c. Thu\u1ed1c \u0111\u1ea1t tr\u1ea1ng th\u00e1i \u1ed5n \u0111\u1ecbnh sau kho\u1ea3ng 3 tu\u1ea7n d\u00f9ng thu\u1ed1c. Th\u1ee9c \u0103n kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 h\u1ea5p thu.<\/p>\n<p>Ph\u00e2n b\u1ed1: Donepezil g\u1eafn k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng kho\u1ea3ng 95%. Sau khi u\u1ed1ng 1 li\u1ec1u 5 mg, sau 10 ng\u00e0y v\u1eabn c\u00f2n kho\u1ea3ng 28% li\u1ec1u d\u00f9ng ch\u01b0a \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i. \u0110i\u1ec1u n\u00e0y ch\u1ee9ng t\u1ecf donepezil v\u00e0\/ho\u1eb7c c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f2n l\u01b0u gi\u1eef trong c\u01a1 th\u1ec3 tr\u00ean 10 ng\u00e0y.<\/p>\n<p>Chuy\u1ec3n h\u00f3a, th\u1ea3i tr\u1eeb: Donepezil \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a qua h\u1ec7 th\u1ed1ng cytocrom P450 th\u00e0nh nhi\u1ec1u ch\u1ea5t chuy\u1ec3n h\u00f3a. Donepezil \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i qua n\u01b0\u1edbc ti\u1ec3u \u1edf c\u1ea3 d\u1ea1ng ch\u01b0a chuy\u1ec3n h\u00f3a v\u00e0 d\u1ea1ng \u0111\u00e3 chuy\u1ec3n h\u00f3a. Th\u1eddi gian b\u00e1n h\u1ee7y trong huy\u1ebft t\u01b0\u01a1ng kho\u1ea3ng 70 gi\u1edd.<\/p>\n<p><strong>5.3 Gi\u1ea3i th\u00edch: <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong>5.4 Thay th\u1ebf thu\u1ed1c : <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/strong><\/p>\n<p><strong>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/strong><\/p>\n<p>&#8230;<\/p>\n<p><strong>6.2. T\u01b0\u01a1ng k\u1ef5 :<\/strong><\/p>\n<p>Kh\u00f4ng \u00e1p d\u1ee5ng.<\/p>\n<p><strong>6.3. B\u1ea3o qu\u1ea3n: <\/strong><\/p>\n<p>N\u01a1i kh\u00f4, tr\u00e1nh \u00e1nh s\u00e1ng, nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30\u00b0C.<\/p>\n<p><strong>6.4. Th\u00f4ng tin kh\u00e1c :<\/strong><\/p>\n<p>Kh\u00f4ng c\u00f3.<\/p>\n<p><strong>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/strong><\/p>\n<p>D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Donepezil hydrochloride Ph\u00e2n lo\u1ea1i: Thu\u1ed1c \u1ee9c ch\u1ebf acetylcholinesterase c\u00f3 th\u1ec3 h\u1ed3i ph\u1ee5c (t\u00e1c d\u1ee5ng trung t\u00e2m). Nh\u00f3m ph\u00e1p l\u00fd: Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine) M\u00e3 ATC (Anatomical Therapeutic Chemical): N06DA02. Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c: Bi\u1ec7t d\u01b0\u1ee3c: Rizax H\u00e3ng s\u1ea3n [&hellip;]<\/p>\n","protected":false},"author":8612,"featured_media":20134,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[670],"class_list":["post-20133","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-donepezil"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/20133","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/8612"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=20133"}],"version-history":[{"count":3,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/20133\/revisions"}],"predecessor-version":[{"id":49485,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/20133\/revisions\/49485"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/20134"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=20133"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=20133"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=20133"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}