{"id":19535,"date":"2020-06-14T10:06:07","date_gmt":"2020-06-14T03:06:07","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=19535"},"modified":"2025-01-08T20:57:24","modified_gmt":"2025-01-08T13:57:24","slug":"clarithromycin-clarithromycin-domesco","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/clarithromycin-clarithromycin-domesco\/","title":{"rendered":"Clarithromycin &#8211; Clarithromycin Domesco"},"content":{"rendered":"<p><strong>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: <\/strong><\/p>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <a href=\"https:\/\/pharmog.com\/wp\/clarithromycin\/\">Clarithromycin<\/a><\/strong><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u1ed1c kh\u00e1ng sinh macrolid b\u00e1n t\u1ed5ng h\u1ee3p.<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): J01F A09.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em><\/strong> <a href=\"https:\/\/pharmog.com\/wp\/clarithromycin-klacid\/\">KLACID , KLACID FORTE, KLACID MR<\/a><\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c:<\/em><\/strong> Clarithromycin Domesco<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: C\u00f4ng ty c\u1ed5 ph\u1ea7n xu\u1ea5t nh\u1eadp kh\u1ea9u y t\u1ebf Domesco<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng: <\/strong><\/p>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>Vi\u00ean n\u00e9n 250 mg v\u00e0 500 mg;<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>CLARITHROMYCIN 500MG<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean n\u00e9n bao phim c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Clarithromycin<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>500 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"426\" height=\"282\" class=\"wp-image-19538\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/06\/word-image-215.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/06\/word-image-215.png 426w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/06\/word-image-215-300x199.png 300w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/06\/word-image-215-242x160.png 242w\" sizes=\"auto, (max-width: 426px) 100vw, 426px\" \/><\/p>\n<p><strong>3. Video by Pharmog:<\/strong><\/p>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe loading=\"lazy\" title=\"[Pharmog SS1 - T\u1eadp 08] - D\u01b0\u1ee3c l\u00fd c\u00e1c thu\u1ed1c kh\u00e1ng sinh\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/0TIIfoiJFwA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<p><strong>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng: <\/strong><\/p>\n<p><strong>4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>Clarithromycin d\u00f9ng ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb \u1edf ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em t\u1eeb 12 tu\u1ed5i tr\u1edf l\u00ean.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb c\u00e1c nhi\u00eam khu\u1ea9n g\u00e2y ra b\u1edfi vi khu\u1ea9n nh\u1ea1y c\u1ea3m bao g\u1ed3m:<\/p>\n<p>Nhi\u00eam khu\u1ea9n \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p d\u01b0\u1edbi nh\u01b0: Vi\u00eam ph\u1ebf qu\u1ea3n c\u1ea5p v\u00e0 m\u1ea1n t\u00ednh, vi\u00eam ph\u1ed5i.<\/p>\n<p>Nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p tr\u00ean nh\u01b0: Vi\u00eam h\u1ecdng, vi\u00eam xoang.<\/p>\n<p>Nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p m\u1eafc ph\u1ea3i \u1edfc\u1ed9ng \u0111\u1ed1ng.<\/p>\n<p>Nhi\u1ec5m khu\u1ea9n da v\u00e0 m\u00f4 m\u1ec1m t\u1eeb nh\u1eb9 \u0111\u1ebfn trung binh.<\/p>\n<p>Clarithromycin \u0111\u01b0\u1ee3c d\u00f9ng ph\u1ed1i h\u1ee3p v\u1edbi 1 thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton nh\u01b0 Omeprazol ho\u1eb7c lansoprazol \u0111\u1ec3 ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec3u tr\u1ecb nhi\u1ec5m Helicobacter pylori \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb lo\u00e9t d\u1ea1 d\u00e0y-t\u00e1 tr\u00e0ng<\/p>\n<p><strong>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/strong><\/p>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p>D\u00f9ng u\u1ed1ng.Th\u1ee9c \u0103n kh\u00f4ng l\u00e0m \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn sinh kh\u1ea3 d\u1ee5ng c\u1ee7a thu\u1ed1c n\u00ean c\u00f3 th\u1ec3 u\u1ed1ng m\u00e0 kh\u00f4ng c\u1ea7n ch\u00fa \u00fd t\u1edbi b\u1eefa \u0103n.<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p>Ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em t\u1eeb 12 tu\u1ed5i tr\u1edf l\u00ean:<\/p>\n<p>Nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p, da v\u00e0 m\u00f4 m\u1ec1m: 500 mg, 2 lan\/ngay, trong 6 \u2014 14 ng\u00e0y.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb Helicobaeter pylori \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb lo\u00e9t d\u1ea1 d\u00e0y-t\u00e1 tr\u00e0ng:<\/p>\n<p>Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb th\u00f4ng th\u01b0\u1eddng l\u00e0 6 &#8211; 14 ng\u00e0y.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb 3 thu\u1ed1c: Clarithromycin 500 mg (2 l\u1ea7n\/ng\u00e0y) v\u00e0 lansoprazol 30 mg (2 l\u1ea7n\/ng\u00e0y) \u0111\u01b0\u1ee3c d\u00f9ng v\u1edbi amoxiIcillin 1000 mg (2 l\u1ea7n\/ng\u00e0y).<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb 3 thu\u1ed1c: Clarithromycin 500 mg (2 l\u1ea7n\/ng\u00e0y) v\u00e0 lansoprazol 30 mg (2 l\u1ea7n\/ng\u00e0y) \u0111\u01b0\u1ee3c d\u00f9ng v\u1edbi metronidazol 400 mg (2 l\u1ea7n\/ng\u00e0y).<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb 3 thu\u1ed1c: Clarithromycin 500 mg (2 l\u1ea7n\/ng\u00e0y) v\u00e0 omeprazol 40 mg\/ng\u00e0y \u0111\u01b0\u1ee3c d\u00f9ng v\u1edbi amoxicillin 1000 mg (2 l\u1ea7n\/ng\u00e0y) ho\u1eb7c metronidazol 400 mg (2 l\u1ea7n\/ng\u00e0y).<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb 3 thu\u1ed1c: Clarithromycin 500 mg (2 l\u1ea7n\/ng\u00e0y) \u0111\u01b0\u1ee3c d\u00f9ng v\u1edbi amoxicillin 1000 mg (2 l\u1ea7n\/ng\u00e0y) va omeprazol 20 mg\/ng\u00e0y.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb 2 thu\u1ed1c: Clarithromycin 500 mg (3 l\u1ea7n\/ng\u00e0y) trong 14 ngay. Clarithromycin n\u00ean \u0111\u01b0\u1ee3c d\u00f9ng v\u1edbi omeprazol 40 mg (1 l\u1ea7n\/ng\u00e0y), trong 28 ng\u00e0y.<\/p>\n<p>Thu\u1ed1c n\u00e0y kh\u00f4ng ph\u00f9 h\u1ee3p s\u1eed d\u1ee5ng cho tr\u1ebb em&lt; 12 tu\u1ed5i.<\/p>\n<p>Ng\u01b0\u1eddi cao tu\u1ed5i: D\u00f9ng li\u1ec1u nh\u01b0 ng\u01b0\u1eddi l\u1edbn.<\/p>\n<p>Ng\u01b0\u1eddi b\u1ec7nh suy th\u1eadn: Kh\u00f4ng c\u1ea7n \u0111i\u1ec3u ch\u1ec9nh li\u00e9u ngo\u1ea1i tr\u1eeb\u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng (\u0111\u1ed9 thanh th\u1ea3i creatinln &lt; 30 ml\/ph\u00fat) do vi\u00ean clarithromycin 500 mg kh\u00f4ng th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng.<\/p>\n<p>C\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u clarithromycin tr\u00ean b\u1ec7nh nh\u00e2n suy gan<\/p>\n<p><strong>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>B\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec3n s\u1eed qu\u00e1 m\u00e3n v\u1edbi clarithromycin, c\u00e1c thu\u1ed1c nh\u00f3m macrolid kh\u00e1c, ho\u1eb7c b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p>B\u1ec7nh nh\u00e2n c\u00f3 \u0111\u1ed9 thanh th\u1ea3i Creatinin d\u01b0\u1edbi 30 ml\/ph\u00fat (vi\u00ean clarithromycin 500 mg kh\u00f4ng th\u1ec3 \u0111i\u1ec3u ch\u1ec9nh li\u1ec1u \u1edfb\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng).<\/p>\n<p>Kh\u00f4ng ph\u1ed1i h\u1ee3p clarithromycin v\u1edbi ergotamin, dihydroergotamin v\u00ec c\u00f3 th\u1ec3 g\u00e2y ng\u1ed9 \u0111\u1ed9c n\u1ea5m c\u1ef1a g\u00e0.<\/p>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh d\u00f9ng \u0111\u1ed5ng th\u1eddi clarithromycin v\u1edbi astemlzol, clsaprid, pimozid v\u00e0 terfenadin c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn k\u00e9o d\u00e0\u00ec kho\u1ea3ng th\u1eddi gian QT v\u00e0 r\u1ed1i lo\u1ea1n nh\u1ecbp tim, bao g\u1ed3m nh\u1ecbp nhanh th\u1ea5t, rung th\u1ea5t v\u00e0 xo\u1eafn \u0111\u1ec9nh. Kh\u00f4ng d\u00f9ng cho b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec3n s\u1eed kho\u1ea3ng th\u1eddi gian QT k\u00e9o d\u00e0i ho\u1eb7c r\u1ed1i lo\u1ea1n nh\u1ecbp th\u1ea5t, bao g\u1ed1m xo\u1eafn \u0111\u1ec9nh.<\/p>\n<p>Kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng \u0111\u1ed5ng th\u1eddi clarithromycin v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf men HMG-CoA (statin) \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1edfi CYP3A4 (lovastatln ho\u1eb7c simvastatin) do t\u0103ng nguy c\u01a1 b\u1ec7nh c\u01a1, ti\u00eau c\u01a1 v\u00e2n. N\u00ean ng\u1eebng \u0111i\u1ec3u tr\u1ecb v\u1edbi c\u00e1c thu\u1ed1c n\u00e0y trong khi \u0111i\u1ec1u tr\u1ecb v\u1edbi clarithromycin.<\/p>\n<p>Kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng clarithromycin \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng colchicin do \u1ee9c ch\u1ebf m\u1ea1nh CYP3A4.<\/p>\n<p>B\u1ec7nh nh\u00e2n b\u1ecb h\u1ea1 kali huy\u1ebft (nguy c\u01a1 k\u00e9o d\u00e0i kho\u1ea3ng th\u1eddi gian QT).<\/p>\n<p>B\u1ec7nh nh\u00e2n suy gan n\u1eb7ng k\u1ebft h\u1ee3p v\u1edbi suy th\u1eadn.<\/p>\n<p><strong>4.4 Th\u1eadn tr\u1ecdng:<\/strong><\/p>\n<p>C\u1ea9n th\u1eadn tr\u1ecdng \u1edf b\u1ec7nh nh\u00e2n b\u1ecb suy th\u1eadn ho\u1eb7c suy gan.<\/p>\n<p>D\u00f9ng clarithromycin d\u00e0i ng\u00e0y c\u00f3 th\u1ec3 l\u00e0m c\u00e1c vi khu\u1ea9n kh\u00f4ng nh\u1ea1y c\u1ea3m v\u1edbi thu\u1ed1c, \u0111\u1eb7c bi\u1ec7t g\u00e2y ti\u00eau ch\u1ea3y v\u00e0 vi\u00eam \u0111\u1ea1i tr\u00e0ng m\u00e0ng gi\u1ea3. Ph\u1ea3i theo d\u00f5i v\u00e0 l\u00e0m kh\u00e1ng sinh \u0111\u1ed3 th\u01b0\u1eddng xuy\u00ean \u0111\u1ec3 c\u00f3 bi\u1ec7n ph\u00e1p \u0111i\u1ec1u tr\u1ecb th\u00edch h\u1ee3p theo kh\u00e1ng sinh \u0111\u1ed5.<\/p>\n<p>B\u1ec7nh nh\u01b0\u1ee3c c\u01a1 tr\u1ea7m tr\u1ecdng \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o \u1edf b\u1ec7nh nh\u00e2n \u0111i\u1ec3u tr\u1ecb b\u1eb1ng clarithromycin.<\/p>\n<p>\u0110\u1ed9c t\u00ednh colchicin \u0111\u00e2 x\u1ea3y ra khi d\u00f9ng \u0111\u1ed5ng th\u1eddi v\u1edbi clarithromycin, \u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi l\u1edbn tu\u1ed5i. N\u1ebfu d\u00f9ng \u0111\u00f3ng th\u1eddi, n\u00ean gi\u00e1m s\u00e1t c\u00e1c tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng nhi\u1ec5m \u0111\u1ed9c colchicin.<\/p>\n<p>Th\u1eadn tr\u1ecdng d\u00f9ng thu\u1ed1c cho b\u1ec7nh nh\u00e2n cao tu\u1ed5i, b\u1ec7nh m\u1ea1ch v\u00e0nh, suy tim, n\u1ed3ng \u0111\u1ed9 magnesi trong m\u00e1u th\u1ea5p, nh\u1ecbp tim ch\u1eadm (&lt; 50 nh\u1ecbp\/ph\u00fat), ho\u1eb7c khi d\u00f9ng chung v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c g\u00e2y k\u00e9o d\u00e0i kho\u1ea3ng th\u1eddi gian QT. Kh\u00f4ng s\u1eed d\u1ee5ng clarithromycin \u1edf ng\u01b0\u1eddi b\u1ec7nh c\u00f3 kho\u1ea3ng th\u1eddi gian QT k\u00e9o d\u00e0i ho\u1eb7c lo\u1ea1n nh\u1ecbp th\u1ea5t, b\u1ec7nh tim \u0111\u00e3 c\u00f3 t\u1eeb tr\u01b0\u1edbc.<\/p>\n<p>Th\u1eadn tr\u1ecdng khi ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c chuy\u1ec3n h\u00f3a qua CYP3A4, c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf HMG-CoA reductase.<\/p>\n<p>C\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng \u0111\u1ed5ng th\u1eddi clarithromycin v\u1edbi benzodiazepin, aminoglycosid.<\/p>\n<p>Ng\u1eebng \u0111i\u1ec1u tr\u1ecb clarithromycin khi c\u00f3 ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn c\u1ea5p t\u00ednh nghi\u00eam tr\u1ecdng nh\u01b0 s\u1ed1c ph\u1ea3n v\u1ec7, h\u1ed9i ch\u1ee9ng Stevens-Johnson v\u00e0 ho\u1ea1i t\u1eed \u0111\u1ed9c bi\u1ec3u b\u00ec, b\u00e0n xu\u1ea5t huy\u1ebft DRESS v\u00e0 hienoch-Schonlein.<\/p>\n<p>C\u1ea7n th\u1eadn tr\u1ecdng khi k\u00ea toa clarithromycin v\u1edbi statin. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p v\u1edbi lovastatin ho\u1eb7c simvastatin.<\/p>\n<p>D\u00f9ng \u0111\u1ed5ng th\u1eddi clarithromycin v\u00e0 c\u00e1c thu\u1ed1c h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft u\u1ed1ng (nh\u01b0 sulphonylurea) v\u00e0\/ho\u1eb7c insulin c\u00f3 th\u1ebf g\u00e2y h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft. Clarithromycin (\u1ee9c ch\u1ebf men CYP3A4) c\u00f3 th\u1ec3 g\u00e2y h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft khi d\u00f9ng \u0111\u1ed5ng th\u1eddi v\u1edbi nateglinid, pioglitazon, repaglinid v\u00e0 roslglitazon. C\u1ea7n theo d\u00f5i n\u1ed5ng \u0111\u1ed9 glucose.<\/p>\n<p>D\u00f9ng \u0111\u1ed5ng th\u1eddi clarithromycin v\u1edbi warfarin, nguy c\u01a1 g\u00e2y xu\u1ea5t huy\u1ebft nghi\u00eam tr\u1ecdng v\u00e0 t\u0103ng \u0111\u00e1ng k\u1ec3 ch\u1ec9 s\u1ed1 INR v\u00e0 th\u1eddi gian prothrombin. C\u1ea7n theo d\u00f5i INR v\u00e0 th\u1eddi gian prothrombin \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n d\u00f9ng \u0111\u1ed3ng th\u1eddi clarithromycin v\u1edbi thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng \u0111\u01b0\u1eddng u\u1ed1ng<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u \u0111\u1ea7y \u0111\u1ee7, tuy nhi\u00ean thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n nh\u01b0 ch\u00f3ng m\u1eb7t, m\u1ea5t \u0111\u1ecbnh h\u01b0\u1edbng, c\u1ea7n th\u1eadn tr\u1ecdng trong nh\u1eefng tr\u01b0\u1eddng h\u1ee3p n\u00e0y.<\/p>\n<p><strong>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/strong><\/p>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: B3<\/p>\n<p>US FDA pregnancy category: C<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>Clarithromycin qua \u0111\u01b0\u1ee3c nhau thai. M\u1eb7c d\u00f9 kh\u00f4ng c\u00f3 c\u00e1c b\u1eb1ng ch\u1ee9ng v\u1ec1 ng\u1ed9 \u0111\u1ed9c thai v\u00e0 qu\u00e1i thai trong c\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt, c\u1ea7n c\u00e2n nh\u00e1c l\u1ee3i \u00edch v\u00e0 r\u1ee7i ro khi d\u00f9ng cho ng\u01b0\u1eddi mang thai v\u00e0 ph\u1ea3i theo d\u00f5i th\u1eadt c\u1ea9n th\u1eadn.<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>Clarithromycin \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9. c\u1ea7n th\u1eadn tr\u1ecdng khi cho ng\u01b0\u1eddi cho con b\u00fa d\u00f9ng clarithromycin<\/p>\n<p><strong>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/strong><\/p>\n<p>Clarithromycin dung n\u1ea1p t\u1ed1t, tr\u00ean l\u00e2m s\u00e0ng c\u00e1c ADR h\u1ea7u nh\u01b0 ch\u1ec9 \u1edf m\u1ee9c nh\u1eb9 ho\u1eb7c tho\u00e1ng qua; ch\u00ec kho\u1ea3ng 1 % t\u00e1c d\u1ee5ng nghi\u00eam tr\u1ecdng \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o. C\u00e1c ADR theo \u0111\u01b0\u1eddng u\u1ed1ng c\u1ee7a clarithromycin ch\u1ee7 y\u1ebfu tr\u00ean \u0111\u01b0\u1eddng ti\u00eau h\u00f3a<\/p>\n<p><em>Th\u01b0\u1eddng g\u1eb7p, ADR &gt;1\/100<\/em><\/p>\n<p>Ti\u00eau h\u00f3a: V\u1ecb gi\u00e1c b\u1ea5t th\u01b0\u1eddng, ti\u00eau ch\u1ea3y, bu\u00f4n n\u00f4n, n\u00f4n, \u0111au d\u1ea1 d\u00e0y, ch\u1ee9ng kh\u00f3 ti\u00eau. R\u1ed1i lo\u1ea1n ti\u00eau h\u00f3a, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u1edf ng\u01b0\u1eddi b\u1ec7nh tr\u1ebb v\u1edbi t\u1ea7n su\u1ea5t 5%. Vi\u00eam \u0111\u1ea1i tr\u00e0ng m\u00e0ng gi\u1ea3 t\u1eeb nh\u1eb9 \u0111\u1ebfn \u0111e d\u1ecda t\u00ednh m\u1ea1ng.<\/p>\n<p>To\u00e0n than: Ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn nh\u01b0 ng\u1ee9a, m\u00e0y \u0111ay, ban da, k\u00edch \u1ee9ng.<\/p>\n<p>Th\u1ea7n kinh trung \u01b0\u01a1ng:\u0110au \u0111\u1ea7u.<\/p>\n<p>Da: Ph\u00e1t ban.<\/p>\n<p>Gan: t\u0103ng th\u1eddi gian prothrombin.<\/p>\n<p>Th\u1eadn: T\u0103ng BUN<\/p>\n<p><em>\u00cdt g\u1eb7p, 1\/1000 &lt; ADR &lt; 1\/100<\/em><\/p>\n<p>Ti\u00eau h\u00f3a: C\u00e1c tri\u1ec7u ch\u1ee9ng \u1ee9 m\u1eadt (\u0111au b\u1ee5ng tr\u00ean, \u0111\u00f4i khi \u0111au nhi\u1ec1u), bu\u1ed5n n\u00f4n, n\u00f4n.<\/p>\n<p>Gan: Ch\u1ee9c n\u0103ng gan b\u1ea5t th\u01b0\u1eddng, bilirubin huy\u1ebft thanh t\u0103ng v\u00e0 th\u01b0\u1eddng k\u00e8m theo v\u00e0ng da, s\u1ed1t ph\u00e1t ban v\u00e0 t\u0103ng b\u1ea1ch c\u00e1u \u01b0a eosin.<\/p>\n<p>Th\u00ednh gl\u00e1c\u0110\u1ec9\u1ebfc (n\u1ebfu d\u00f9ng li\u1ec1u cao) th\u1ea9n kinh gi\u00e1c quan c\u00f3 th\u1ec3 h\u1ed5i ph\u1ee5c.<\/p>\n<p><em>C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00e1c (&lt; 1%):<\/em><\/p>\n<p>Vi\u00eam ru\u1ed9t do Clostridium difficile, t\u0103ng phosphatase ki\u1ec1m, ph\u1ea3n v\u1ec7, bi\u1ebfng \u0103n, lo \u00e2u, t\u0103ng l\u00fa l\u1eabn, m\u1ea5t ph\u01b0\u01a1ng h\u01b0\u1edbng, t\u0103ng GGT, vi\u00eam l\u01b0\u1ee1i, \u1ea3o gi\u00e1c, gi\u1ea3m th\u00ednh l\u1ef1c, suy gan, vi\u00eam gan, h\u1ea1 glucose huy\u1ebft, m\u1ea5t ng\u1ee7, k\u00e9o d\u00e0i th\u1eddi gian QT, \u0111\u1ed9ng kinh, t\u0103ng Creatinin huy\u1ebft thanh, h\u1ed9i ch\u1ee9ng Stevens-Johnson, vi\u00eam d\u1ea1 d\u00e0y, gi\u1ea3m ti\u1ec3u c\u1ea7u, \u0111\u1ed5i m\u00e0u l\u01b0\u1ee1i, \u0111\u1ed5i m\u00e0u r\u0103ng, t\u0103ng men gan, run, lo\u1ea1n nh\u1ecbp th\u1eadt, ch\u00f3ng m\u1eb7t.<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<p><strong>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/strong><\/p>\n<p>Ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c. V\u1edbi c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i nh\u1eb9, th\u01b0\u1eddng ch\u1ec9 c\u1ea7n ng\u1eebng thu\u1ed1c. Tr\u01b0\u1eddng h\u1ee3p m\u1eabn c\u1ea3m n\u1eb7ng ho\u1eb7c ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, c\u1ea7n ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 (gi\u1eef tho\u00e1ng kh\u00ed v\u00e0 d\u00f9ng epinephrin, th\u1edf oxygen, d\u00f9ng kh\u00e1ng histamin, corticoid&#8230;).<\/p>\n<p><strong>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/strong><\/p>\n<p>Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh d\u00f9ng \u0111\u00f3ng th\u1eddi clarithromycin v\u1edbi c\u00e1c thu\u1ed1c sau: Cisaprid, pimozid, astemizol, terfenadin, ergotamin, dihydroergotamln, lovastatin, simvastatin.<\/p>\n<p>T\u00e1c d\u1ee5ng c\u1ee7a clarithromycin c\u00f3 th\u1ec3 b\u1ecb gi\u1ea3m khi d\u00f9ng v\u1edbi c\u00e1c thu\u1ed1c sau: C\u00e1c thu\u1ed1c g\u00e2y c\u1ea3m \u1ee9ng CYP3A4 (nh\u01b0 rifampicin, phenytoin, carbamazepin, phenobarbital), c\u00e1c thu\u1ed1c g\u00e2y c\u1ea3m \u1ee9ng h\u1ec7 th\u1ed1ng chuy\u1ec3n h\u00f3a cytochrom P450 (nh\u01b0 efavirenz, nevirapin, rifampicin, rifabutin, rifapentin), etravirin, c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf protease.<\/p>\n<p>T\u00e1c d\u1ee5ng c\u1ee7a clarithromycin c\u00f3 th\u1ec3 t\u0103ng l\u00ean khi d\u00f9ng \u0111\u1ed5ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c sau:Thu\u1ed1c ch\u1ed1ng n\u1ea5m, c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf CYP3A4, c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf protease.<\/p>\n<p>Clarithromycin l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng c\u1ee7a c\u00e1c thu\u1ed1c sau: Alprazolam, astemizol, carbamazepin, cilostazol, cisaprid, cyclosporin, disopyramid, c\u00e1c alkaloid n\u1ea5m c\u1ef1a g\u00e0, methylprednisolon, midazolam, thu\u1ed1c \u0111\u1ed1i kh\u00e1ng vitamin K, pimozid, quinidin, rifabutin, sildenafil, sirolimus, tacrolimus, terfenadin, triazolam, vinblastin,omeprazol, phenytoin, theophyllin, valproat, nateglinid, repaglinid, tadalafil, vardenafil, benzodiazepin, colchicin, glycosid tim, thu\u1ed1c ch\u1eb9n k\u00eanh calci, c\u00e1c thu\u1ed1c ch\u1ed1ng n\u1ea5m, ch\u1ea5t n\u1ebfn CYP3A4, c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf HMG-CoA reductase.<\/p>\n<p>Clarithromycin c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng c\u1ee7a c\u00e1c thu\u1ed1c sau: Zidovudin, clopidogrel, v\u1eafcxin th\u01b0\u01a1ng h\u00e0n.<\/p>\n<p>C\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng \u0111\u1ed5ng th\u1eddi clarithromycin v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c g\u00e2y \u0111\u1ed9c tr\u00ean tai, \u0111\u1eb7c bi\u1ec7t l\u00e0 v\u1edbi aminoglycosid.<\/p>\n<p>Verapamil: H\u1ea1 huy\u1ebft \u00e1p, ch\u1eadm nh\u1ecbp tim v\u00e0 toan lactic \u0111\u00e3 \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y \u1edf b\u1ec7nh nh\u00e2n d\u00f9ng \u0111\u1ed5ng th\u1eddi clarithromycin v\u00e0 verapamil.<\/p>\n<p>Clarithromycin \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh kh\u00f4ng t\u01b0\u01a1ng t\u00e1c v\u1edbi thu\u1ed1c tr\u00e1nh thai.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/strong><\/p>\n<p>C\u00e1c b\u00e1o c\u00e1o cho th\u1ea5y khi u\u1ed1ng m\u1ed9t l\u01b0\u1ee3ng l\u1edbn clarithromycin c\u00f3 th\u1ec3 t\u0103ng tri\u1ec7u ch\u1ee9ng b\u1ec7nh d\u1ea1 d\u00e0y-ru\u1ed9t. M\u1ed9t b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec3n s\u1eed r\u1ed1i lo\u1ea1n l\u01b0\u1ee1ng c\u1ef1c u\u1ed5ng 8 g clarithromycin v\u00e0 cho th\u1ea5y t\u00ecnh tr\u1ea1ng t\u00e2m th\u00e1n b\u1ecb thay \u0111\u1ed5i, b\u1ec7nh hoang t\u01b0\u1edfng, gi\u1ea3m kali huy\u1ebft v\u00e0 gi\u1ea3m oxy huy\u1ebft.\u0110i\u1ec3u tr\u1ecb ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng do qu\u00e1 li\u1ec3u b\u1eb1ng c\u00e1ch r\u1eeda d\u1ea1 d\u00e0y v\u00e0 \u0111i\u1ebfu tr\u1ecb h\u1ed7 tr\u1ee3. Gi\u1ed1ng nh\u01b0 nh\u1eefng macrolid kh\u00e1c, n\u1ed3ng \u0111\u1ed9 clarithromycin trong huy\u1ebft thanh kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi th\u1ea9m ph\u00e2n m\u00e1u ho\u1eb7cth\u1ea9m ph\u00e2n m\u00e0ng b\u1ee5ng.<\/p>\n<p><strong>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/strong><\/p>\n<p><strong>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/strong><\/p>\n<p>Clarithromycin l\u00e0 kh\u00e1ng sinh macrolid b\u00e1n t\u1ed5ng h\u1ee3p.Clarithromycin th\u01b0\u1eddng c\u00f3 t\u00e1c d\u1ee5ng k\u00ecm khu\u1ea9n \u0111\u1ed1i v\u1edbi nhi\u1ec1u vi khu\u1ea9n Gram d\u01b0\u01a1ng v\u00e0 m\u1ed9t s\u1ed1 vi khu\u1ea9n Gram \u00e2m.Thu\u1ed1c c\u00f3 th\u1ec3 c\u00f3 t\u00e1c d\u1ee5ng di\u1ec7t khu\u1ea9n \u1edf li\u1ec1u cao ho\u1eb7c \u0111\u1ed1i v\u1edbi nh\u1eefng ch\u1ee7ng r\u1ea5t nh\u1ea1y c\u1ea3m. Clarithromycin \u1ee9c ch\u1ebf s\u1ef1 t\u1ed5ng h\u1ee3p protein \u1edf vi khu\u1ea9n nh\u1ea1y c\u1ea3m b\u1eb1ng c\u00e1ch g\u1eafn v\u1edbi ti\u1ec3u \u0111\u01a1n v\u1ecb 50S ribosom, v\u00ec v\u1eady ng\u0103n ch\u1eb7n s\u1ef1 di chuy\u1ec3n c\u1ee7a aminocyl transfer-RNA v\u00e0 \u1ee9c ch\u1ebf s\u1ef1 t\u1ed5ng h\u1ee3p polypeptid.<\/p>\n<p>Clarithromycin \u0111\u01b0\u1ee3c ph\u00e2n b\u1ed1 r\u1ed9ng r\u00e3i v\u00e0o c\u00e1c m\u00f4 v\u00e0 d\u1ecbch c\u01a1 th\u1ec3. Do s\u1ef1 x\u00e2m nh\u1eadp m\u00f4 cao, n\u1ed3ng \u0111\u1ed9 n\u1ed9i b\u00e0o cao h\u01a1n n\u00f3ng \u0111\u1ed9 trong huy\u1ebft thanh. C\u00e1c th\u00f4ng s\u1ed1 d\u01b0\u1ee3c l\u1ef1c ch\u00ednh \u0111\u1ec3 d\u1ef1 \u0111o\u00e1n hi\u1ec7u qu\u1ea3 \u0111i\u1ec3u tr\u1ecb c\u1ee7a macrolid l\u00e0 ch\u01b0a thuy\u1ebft ph\u1ee5c. Th\u1eddi gian tr\u00ean MIC (T\/MIC) l\u1ea7 y\u1ebfu t\u1ed1 quy\u1ebft \u0111\u1ecbnh t\u1ed1t nh\u1ea5t cho hi\u1ec7u qu\u1ea3 \u0111i\u1ec3u tr\u1ecb c\u1ee7a clarithromycin. V\u00ec n\u1ed5ng \u0111\u1ed9 clarithromycin trong c\u00e1c m\u00f4 ph\u1ed5i v\u00e0 d\u1ecbch t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 v\u01b0\u1ee3t qu\u00e1 n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng, n\u00ean vi\u1ec7c coi n\u1ed1ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng nh\u01b0 l\u00e0 th\u00f4ng s\u1ed1 \u0111\u1ec3 d\u1ef1 \u0111o\u00e1n ch\u00ednh x\u00e1c \u0111\u00e1p \u1ee9ng c\u00e1c b\u1ec7nh nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p l\u00e0 kh\u00f4ng \u0111\u1ea7y \u0111\u1ee7.<\/p>\n<p><em>* Ph\u1ed5 kh\u00e1ng khu\u1ea9n:<\/em><\/p>\n<p><em>In vitro,<\/em> clarithromycin c\u00f3 t\u00e1c d\u1ee5ng t\u01b0\u01a1ng t\u1ef1 ho\u1eb7c m\u1ea1nh h\u01a1n erythromycin \u0111\u1ed1i v\u1edbi c\u00e1c vi khu\u1ea9n nh\u1ea1y c\u1ea3m v\u1edbi erythromycin v\u00e0 c\u0169ng c\u00f3 ho\u1ea1t t\u00ednh ch\u1ed1ng m\u1ed9t s\u1ed1 vi sinh (nh\u01b0 <em>Mycobacteria<\/em> kh\u00f4ng \u0111i\u1ec3n h\u00ecnh, <em>Toxoplasma).<\/em><\/p>\n<p>Vi khu\u1ea9n nh\u1ea1y c\u1ea3m:<\/p>\n<p>Vi khu\u1ea9n hi\u1ebfu kh\u00ed Gram d\u01b0\u01a1ng: Clarithromycin c\u00f3 t\u00e1c d\u1ee5<em>ng in vitro<\/em> m\u1ea1nh h\u01a1n erythromycin \u0111\u1ed1i v\u1edbi c\u00e1c vi khu\u1ea9n nh\u1ea1y c\u1ea3m <em>streptococci v\u00e0 staphylococci.<\/em><\/p>\n<p>Clarithromycin c\u0169ng c\u00f3 t\u00e1c d\u1ee5ng tr\u1ebdn m\u1ed9t v\u00e0i tr\u1ef1c khu\u1ea9n hi\u1ebfu kh\u00ed Gram d\u01b0\u01a1ng nh\u01b0 <em>Listeria monocytogenes<\/em> v\u00e0 m\u1ed9t s\u1ed1 <em>Corynebacterium.<\/em><\/p>\n<p><em>Vi<\/em> khu\u1ea9n hi\u1ebfu kh\u00ed Gram \u00e2m: <em>In vitro,<\/em> clarithromycin c\u00f3 ho\u1ea1t t\u00ednh \u0111\u1ed1i v\u1edbi m\u1ed9t s\u1ed5 vi khu\u1ea9n Gram \u00e2m nh\u01b0 <em>Neisseria gonorrhoeae<\/em> v\u00e0 <em>Moraxella (Branhamella) catarrhalis, Haemophilus influenzae, H. parainfluenzae, Pasteurella multocida. <\/em>Clarithromycin c\u00f3 t\u00e1c d\u1ee5ng <em>in vitro<\/em> m\u1ea1nh h\u01a1n erythromycin v\u1edbi <em>Legionella<\/em> spp., <em>Campylobacter<\/em> spp., <em>Bordetella pertussis.<\/em> Clarithromycin c\u00f3 t\u00e1c d\u1ee5ng v\u1edbi h\u1ea7u h\u1ebft c\u00e1c ch\u1ee7ng <em>Helicobacter pylori,<\/em> thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng tr\u00ean <em>Helicobacter pylori<\/em> m\u1ea1nh h\u01a1n c\u00e1c macrolid kh\u00e1c<\/p>\n<p>Clarithromycin c\u00f3 t\u00e1c d\u1ee5ng m\u1ea1nh h\u01a1n erythromycin v\u00e0 azithromycin \u0111\u1ed1i v\u1edbi <em>Mycobacteria<\/em> bao g\u1ed3m <em>Mycobacterium avium<\/em> ph\u1ee9c h\u1ee3p v\u00e0 <em>M. leprae.<\/em><\/p>\n<p>C\u00e1c vi khu\u1ea9n hi\u1ebfu kh\u00ed kh\u00e1c: Clarithromycin c\u00f3 t\u00e1c d\u1ee5ng v\u1edbi <em>Mycoplasma pneumonia, Ureaplasma urealyticum, Clamydia trachomatis v\u00e0<\/em> m\u1ed9t s\u1ed1 ch\u1ee7ng c\u1ee7a c. <em>pneumoniae.<\/em><\/p>\n<p><em>Vi<\/em> khu\u1ea9n ky kh\u00ed: in <em>vitro,<\/em> clarithromycin c\u00f3 ho\u1ea1t t\u00ednh v\u1edbi h\u1ea7u h\u1ebft c\u00e1c ch\u1ee7ng <em>Peptococcus, Peptostreptococcus, Clostridium perfr\u00edngens, Propioniba\u01a1erium acn\u00e9s,<\/em> c\u00e1c ch\u1ee7ng <em>Prevotella<\/em> spp., <em>Bacteroides fragills.<\/em><\/p>\n<p>C\u00e1c vi khu\u1ea9n kh\u00e1c nh\u1ea1y c\u1ea3m v\u1edbi thu\u1ed1c bao g\u1ed3m <em>Toxoplasma gondii, Gardnerella vaginalis, Borrelia burgdorieriva Cryptosporidis.<\/em><\/p>\n<p>Ch\u1ea5t chuy\u00ean h\u00f3a 14-hydroxy clarithromycin c\u00f3 ho\u1ea1t t\u00ednh v\u00e0 c\u00f3 th\u1ec3 hi\u1ec7p \u0111\u1ed3ng <em>in vitro<\/em> v\u1edbi thu\u1ed1c m\u1eb9 \u0111\u1ec3 l\u00e0m t\u0103ng \u0111\u00e1ng k\u1ec3 ho\u1ea1t t\u00ednh c\u1ee7a clarithromycin tr\u00ean l\u00e2m s\u00e0ng \u0111\u1ed1i v\u1edbi <em>Haemophilus influenzae, Legionella<\/em> spp.<\/p>\n<p><em>* Kh\u00e1ng thu\u1ed1c:<\/em><\/p>\n<p>Kh\u00e1ng c\u00e1c kh\u00e1ng s\u00ednh macrolid th\u01b0\u1eddng li\u00ean quan \u0111\u1ebfn thay \u0111\u1ed5i \u1edf v\u1ecb tr\u00ed \u0111\u00edch g\u1eafn v\u1edbi kh\u00e1ng sinh, nh\u01b0ng kh\u00e1ng thu\u1ed1c c\u0169ng c\u00f2n do s\u1ef1 t\u0103ng c\u01b0\u1eddng \u0111\u1ea9y kh\u00e1ng sinh ra ngo\u00e0i c\u1ee7a vi khu\u1ea9n. S\u1ef1 kh\u00e1ng thu\u1ed1c c\u00f3 th\u1ec3 qua trung gian nhi\u00eam s\u1eafc th\u1ec3 ho\u1eb7c plasmid. Vi khu\u1ea9n kh\u00e1ng macrolid t\u1ea1o ra m\u1ed9t enzyrn l\u00e0m methyl h\u00f3a adenin c\u00f2n d\u01b0 l\u1ea1i \u1edf RNA c\u1ee7a ribosom v\u00e0 cu\u1ed1i c\u00f9ng \u1ee9c ch\u1ebf kh\u00e1ng sinh g\u1eafn v\u00e0o r\u00edbosom.<\/p>\n<p>C\u00e1c vi khu\u1ea9n kh\u00e1ng erythromycin th\u01b0\u1eddng kh\u00e1ng t\u1ea5t c\u1ea3 c\u00e1c macrolid v\u00ec nh\u1eefng thu\u1ed1c n\u00e0y \u0111\u1ec1u k\u00edch th\u00edch enzym methylase.<\/p>\n<p>Kh\u00e1ng erythromycin c\u1ee7a <em>Streptococcus pneumoniae<\/em> th\u01b0\u1eddng kh\u00e1ng ch\u00e9o v\u1edbi clarithromycin. C\u00e1c ch\u1ee7ng vi khu\u1ea9n kh\u00e1ng penicillin c\u0169ng kh\u00e1ng cao v\u1edbi clarithromycin v\u00e0 \u0111\u00e3 ph\u00e2n l\u1eadp \u0111\u01b0\u1ee3c <em>Helicobacter pylori<\/em> kh\u00e1ng thu\u1ed1c. Do s\u1ef1 kh\u00e1ng thu\u1ed1c ph\u00e1t tri\u1ec3n nhanh v\u1edbi <em>M. avium<\/em> khi d\u00f9ng ri\u00eang clarithromycin n\u00ean li\u1ec7u ph\u00e1p \u0111i\u1ec3u tr\u1ecb k\u1ebft h\u1ee3p th\u01b0\u1eddng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o.<\/p>\n<p>H\u1ea9u h\u1ebft c\u00e1c <em>enterococci nh\u01b0 Enterococcus faecalis<\/em> \u0111\u00e3 kh\u00e1ng c\u1ea3 clarithromycin v\u00e0 erythromycin.<\/p>\n<p>Kh\u00e1ng thu\u1ed1c \u0111\u00e3 x\u1ea3y ra v\u1edbi c\u00e1c vi khu\u1ea9n nh\u01b0: <em>Staphylococcus<\/em> kh\u00e1ng oxacillin, <em>Staphylococcus<\/em> coagulase \u00e2m t\u00ednh (S. <em>epidermidis<\/em>). Enterobacteriaceae <em>(Salmonella enteriditis-, Yersinia enterocolitica, Shigella<\/em> v\u00e0 <em>Vibrio<\/em> spp).<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>Clarithromycin l\u00e0 kh\u00e1ng sinh macrolid b\u00e1n t\u1ed5ng h\u1ee3p. Clarithromycin th\u01b0\u1eddng c\u00f3 t\u00e1c d\u1ee5ng k\u00ecm khu\u1ea9n, m\u1eb7c d\u00f9 c\u00f3 th\u1ec3 c\u00f3 t\u00e1c d\u1ee5ng di\u1ec7t khu\u1ea9n \u1edf li\u1ec1u cao ho\u1eb7c \u0111\u1ed1i v\u1edbi nh\u1eefng ch\u1ee7ng r\u1ea5t nh\u1ea1y c\u1ea3m. Clarithromycin \u1ee9c ch\u1ebf s\u1ef1 t\u1ed5ng h\u1ee3p protein \u1edf vi khu\u1ea9n nh\u1ea1y c\u1ea3m b\u1eb1ng c\u00e1ch g\u1eafn v\u1edbi ti\u1ec3u \u0111\u01a1n v\u1ecb 50S ribosom. V\u1ecb tr\u00ed t\u00e1c d\u1ee5ng c\u1ee7a clarithromycin h\u00ecnh nh\u01b0 c\u0169ng l\u00e0 v\u1ecb tr\u00ed t\u00e1c d\u1ee5ng c\u1ee7a erythromycin, clindamycin, lincomycin v\u00e0 cloramphenicol.<\/p>\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe loading=\"lazy\" title=\"[Pharmog SS2 -  T\u1eadp 01] H\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng kh\u00e1ng sinh nh\u00f3m Macrolide\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/AdiSYpncXLk?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/p>\n<p><strong>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/strong><\/p>\n<p>Clarithromycin khi u\u1ed1ng \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a v\u00e0 ch\u1ecbu s\u1ef1 chuy\u1ec3n h\u00f3a \u0111\u1ea7u ti\u00ean \u1edf m\u1ee9c \u0111\u1ed9 cao, sinh kh\u1ea3 d\u1ee5ng tuy\u1ec7t \u0111\u1ed1i c\u1ee7a clarithromycin kho\u1ea3ng 55%. Th\u1ee9c \u0103n l\u00e0m gi\u1ea3m h\u1ea5p thu nh\u01b0ng kh\u00f4ng l\u00e0m gi\u1ea3m sinh kh\u1ea3 d\u1ee5ng. N\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft thanh \u0111\u1ea1t \u0111\u01b0\u1ee3c kho\u1ea3ng 2-3 gi\u1edd sau khi u\u1ed1ng. N\u00f3ng \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh \u0111\u1ea1t \u0111\u01b0\u1ee3c trong kho\u1ea3ng 3-4 ng\u00e0y, n\u00f4ng \u0111\u1ed9 \u0111\u1ec9nh c\u1ee7a clarithromycin v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh 14-hydroxy clarithromycin theo th\u1ee9 t\u1ef1 kho\u1ea3ng 1 v\u00e0 0,6 microgam\/ml.<\/p>\n<p>D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a clarithromycin kh\u00f4ng tuy\u1ebfn t\u00ednh v\u00e0 ph\u1ee5 thu\u1ed9c li\u1ebfu. C\u00e1c li\u1ec1u l\u1edbn c\u00f3 th\u1ec3 t\u1ea1o n\u00ean c\u00e1c n\u00f3ng \u0111\u1ed9 \u0111\u1ec9nh t\u0103ng kh\u00f4ng theo t\u1ef7 l\u1ec7 thu\u1eadn do chuy\u1ec3n h\u00f3a thu\u1ed1c b\u1ecb b\u00e3o h\u00f2a. S\u1ef1 ph\u1ee5 thu\u1ed9c kh\u00f4ng tuy\u1ebfn t\u00ednh s\u1ebd kh\u00f4ng \u0111\u00e1ng k\u1ec3 n\u1ebfu d\u00f9ng li\u1ec1u khuy\u1ebfn c\u00e1o 500 mg, c\u00e1ch 8 gi\u1edd ho\u1eb7c 12 gi\u1edd m\u1ed9t l\u1ea9n.<\/p>\n<p>Ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh l\u1eb1 14-hydroxy clarithromycin c\u0169ng c\u00f3 ho\u1ea1t t\u00ednh v\u00e0 c\u00f3 th\u1ec3 t\u0103ng c\u01b0\u1eddng ho\u1ea1t t\u00ednh c\u1ee7a clarithromycin in vitro.<\/p>\n<p>Clarithromycin x\u00e2m nh\u1eadp t\u1ed1t v\u00e0o c\u00e1c ng\u0103n kh\u00e1c nhau v\u1edbi th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 Vd = 200 \u2013 400 1, ph\u00e2n b\u1ed1 \u1edf m\u00f4 g\u1ea5p nhi\u1ec1u l\u1ea7n \u1edf huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<p>Clarithromycin v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh 14-hydroxy clarithromycin \u0111\u01b0\u1ee3c ph\u00e2n b\u1ed1 r\u1ed9ng r\u00e3i v\u00e0 n\u1ed3ng \u0111\u1ed9 trong m\u00f4 v\u01b0\u1ee3t n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft thanh do m\u1ed9t ph\u1ea9n thu\u1ed1c \u0111\u01b0\u1ee3c thu n\u1ea1p v\u00e0o trong t\u1ebf b\u00e0o. Kho\u1ea3ng 42 &#8211; 72% n\u1ed3ng \u0111\u1ed9 thu\u1ed1c g\u1eafn v\u1edbi protein huy\u1ec1t t\u01b0\u01a1ng. \u1ede n\u1ed3ng \u0111\u1ed9 \u0111i\u1ec1u tr\u1ecb th\u00f4ng th\u01b0\u1eddng, clarithromycin \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n c\u00f3 trong s\u1eefa m\u1eb9 v\u00e0 trong d\u1ecbch n\u00e3o t\u1ee7y nh\u01b0ng hi\u1ec7u qu\u1ea3 trong \u0111i\u1ec1u tr\u1ecb vi\u00eam m\u00e0ng n\u00e3o c\u00f2n ch\u01b0a r\u00f5.<\/p>\n<p>Thu\u1ed1c chuy\u1ec3n h\u00f3a nhi\u1ec1u \u1edf gan v\u00e0 th\u1ea3i ra ph\u00e2n qua \u0111\u01b0\u1eddng m\u1eadt (5-10% thu\u1ed1c m\u1eb9). M\u1ed9t ph\u1ea7n \u0111\u00e1ng k\u1ec3 \u0111\u01b0\u1ee3c th\u1ea3i qua n\u01b0\u1edbc ti\u1ec3u. Kho\u1ea3ng 30% li\u1ec1u 500 mg \u0111\u01b0\u1ee3c th\u00e0i qua n\u01b0\u1edbc ti\u1ec3u d\u01b0\u1edbi d\u1ea1ng kh\u00f4ng b\u1ecb chuy\u1ec3n h\u00f3a. 14-hydroxy clarithromycin c\u0169ng nh\u01b0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a kh\u00e1c c\u0169ng \u0111\u01b0\u1ee3c th\u1ea3i qua n\u01b0\u1edbc ti\u1ec3u 10-15%. Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a clarithromycin v\u00e0 14-hydroxy clarithromycin kho\u1ea3ng 5 &#8211; 7 gi\u1edd va 7 &#8211; 9 gi\u1edd khi ng\u01b0\u1eddi b\u1ec7nh u\u1ed1ng li\u1ec1u 500 mg, c\u00e1ch 8 -12 gi\u1edd m\u1ed9t l\u1ea7n. Th\u1eddi gian b\u00e1n th\u1ea3i b\u1ecb k\u00e9o d\u00e0i \u1edf ng\u01b0\u1eddi b\u1ec7nh suy th\u1eadn<\/p>\n<p><strong>5.3 Gi\u1ea3i th\u00edch: <\/strong><\/p>\n<p>Thu\u1ed1c \u1ea3nh h\u01b0\u1edfng \u00edt t\u1edbi d\u1ea1 d\u00e0y, n\u00ean u\u1ed1ng xa b\u1eefa \u0103n.<\/p>\n<p><strong>5.4 Thay th\u1ebf thu\u1ed1c : <\/strong><\/p>\n<p>N\u1ebfu d\u1ecb \u1ee9ng c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng sang c\u00e1c thu\u1ed1c kh\u00e1ng sinh nh\u00f3m kh\u00e1c.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/strong><\/p>\n<p><strong>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/strong><\/p>\n<p>Starch 1500, T\u1ec9nh b\u1ed9t ng\u00f4, Povidon K90, Microcrystallin cellulose PH102, Natri starch ,glycolat, Talc, Magnesi stearat, Colloidal silicon dioxid A200, Acid stearic, Hydroxypropyl methylcellulose 15cP, Hydroxypropyl methylcellulose 6cP, Polyethylen glycol 6000, Titan dioxid,Quinolin yellow lake, Ethanol 96%.<\/p>\n<p><strong>6.2. T\u01b0\u01a1ng k\u1ef5 :<\/strong><\/p>\n<p>Kh\u00f4ng \u00e1p d\u1ee5ng.<\/p>\n<p><strong>6.3. B\u1ea3o qu\u1ea3n: <\/strong><\/p>\n<p>N\u01a1i kh\u00f4, tr\u00e1nh \u00e1nh s\u00e1ng, nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30\u00b0C.<\/p>\n<p><strong>6.4. Th\u00f4ng tin kh\u00e1c :<\/strong><\/p>\n<p>Kh\u00f4ng c\u00f3.<\/p>\n<p><strong>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/strong><\/p>\n<p>D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Clarithromycin Ph\u00e2n lo\u1ea1i: Thu\u1ed1c kh\u00e1ng sinh macrolid b\u00e1n t\u1ed5ng h\u1ee3p. Nh\u00f3m ph\u00e1p l\u00fd: Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine) M\u00e3 ATC (Anatomical Therapeutic Chemical): J01F A09. Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c: KLACID , KLACID FORTE, KLACID MR Bi\u1ec7t d\u01b0\u1ee3c: Clarithromycin Domesco [&hellip;]<\/p>\n","protected":false},"author":8612,"featured_media":19538,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[656],"class_list":["post-19535","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-clarithromycin"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/19535","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/8612"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=19535"}],"version-history":[{"count":3,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/19535\/revisions"}],"predecessor-version":[{"id":49782,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/19535\/revisions\/49782"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/19538"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=19535"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=19535"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=19535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}