{"id":19371,"date":"2020-06-13T22:14:07","date_gmt":"2020-06-13T15:14:07","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=19371"},"modified":"2025-01-08T20:57:35","modified_gmt":"2025-01-08T13:57:35","slug":"clopidogrel-clorazer","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/clopidogrel-clorazer\/","title":{"rendered":"Clopidogrel &#8211; Clorazer"},"content":{"rendered":"<p><strong>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: <\/strong><\/p>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <a href=\"https:\/\/pharmog.com\/wp\/clopidogrel\/\">Clopidogrel<\/a><\/strong><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u00f4\u0301c ch\u00f4\u0301ng \u0111\u00f4ng va\u0300 la\u0300m tan huy\u00ea\u0301t kh\u00f4\u0301i,<\/em> <em>Thu\u1ed1c \u1ee9c ch\u1ebf k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u.<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): B01AC04.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em> <a href=\"https:\/\/pharmog.com\/wp\/clopidogrel-plavix\/\">PLAVIX<\/a><\/strong><\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c:<\/em><\/strong> Clopidogrel 75 \u2013 MV , Clorazer<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: C\u00f4ng ty TNHH US pharma USA<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng: <\/strong><\/p>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>Vi\u00ean n\u00e9n 75 mg;<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>CLORAZER 75<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean n\u00e9n bao phim c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Clopidogrel<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>75 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"322\" height=\"283\" class=\"wp-image-19372\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/06\/word-image-152.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/06\/word-image-152.png 322w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/06\/word-image-152-300x264.png 300w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/06\/word-image-152-182x160.png 182w\" sizes=\"auto, (max-width: 322px) 100vw, 322px\" \/><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>CLOPIDOGREL 75 \u2013 MV<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean n\u00e9n bao phim c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Clopidogrel<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>75 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"298\" height=\"222\" class=\"wp-image-19373\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/06\/word-image-153.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/06\/word-image-153.png 298w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/06\/word-image-153-215x160.png 215w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/06\/word-image-153-90x68.png 90w\" sizes=\"auto, (max-width: 298px) 100vw, 298px\" \/><\/p>\n<p><strong>3. Video by Pharmog:<\/strong><\/p>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe loading=\"lazy\" title=\"[Pharmog SS1 - T\u1eadp 03] - D\u01b0\u1ee3c l\u00fd thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng, thu\u1ed1c c\u1ea7m m\u00e1u\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/Km6TTc9GQuU?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<p><strong>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng: <\/strong><\/p>\n<p><strong>4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>L\u00e0m gi\u1ea3m hay d\u1ef1 ph\u00f2ng c\u00e1c bi\u1ebfn c\u1ed1 huy\u1ebft kh\u1ed1i do x\u01a1 v\u1eefa \u0111\u1ed9ng m\u1ea1ch (nh\u1ed3i m\u00e1u c\u01a1 tim, \u0111\u1ed9t qu\u1ef5, tai bi\u1ebfn m\u1ea1ch m\u00e1u n\u00e3o) \u1edf b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed x\u01a1 v\u1eefa \u0111\u1ed9ng m\u1ea1ch bi\u1ec3u hi\u1ec7n b\u1edfi nh\u1ed3i m\u00e1u c\u01a1 tim (trong th\u1eddi gian v\u00e0i ng\u00e0y \u0111\u1ebfn d\u01b0\u1edbi 35 ng\u00e0y), \u0111\u1ed9t qu\u1ef5, thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 (t\u1eeb 7 ng\u00e0y \u0111\u1ebfn d\u01b0\u1edbi 6 th\u00e1ng) hay b\u1ec7nh \u0111\u1ed9ng m\u1ea1ch ngo\u1ea1i bi\u00ean \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh.<\/p>\n<p>D\u00f9ng k\u1ebft h\u1ee3p v\u1edbi Aspirin \u1edf b\u1ec7nh nh\u00e2n b\u1ecb h\u1ed9i ch\u1ee9ng \u0111au th\u1eaft ng\u1ef1c kh\u00f4ng \u1ed5n \u0111\u1ecbnh hay nh\u1ed3i m\u00e1u c\u01a1 tim kh\u00f4ng c\u00f3 s\u00f3ng Q.<\/p>\n<p><strong>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/strong><\/p>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p>D\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng, c\u00f3 th\u1ec3 u\u1ed1ng trong ho\u1eb7c ngo\u00e0i b\u1eefa \u0103n.<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p>Ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh v\u00e0 ng\u01b0\u1eddi gi\u00e0 : D\u00f9ng li\u1ec1u 1 vi\u00ean (75 mg\/l\u1ea7n\/ng\u00e0y).<\/p>\n<p>B\u1ec7nh nh\u00e2n \u0111au th\u1eaft ng\u1ef1c kh\u00f4ng \u1ed5n \u0111\u1ecbnh hay nh\u1ed3i m\u00e1u c\u01a1 tim kh\u00f4ng c\u00f3 s\u00f3ng Q: Kh\u1edfi \u0111\u1ea7u 4 vi\u00ean (300 mg)\/ ng\u00e0y \u0111\u1ea7u ti\u00ean. Sau \u0111\u00f3 ti\u1ebfp t\u1ee5c li\u1ec1u 75 mg\/ng\u00e0y (K\u1ebft h\u1ee3p v\u1edbi Aspirin 75-325mg \/ng\u00e0y) \u1edf nh\u1eefng ng\u00e0y ti\u1ebfp theo.<\/p>\n<p>Ch\u01b0a c\u00f3 d\u1eef li\u1ec7u v\u1ec1 s\u1ef1 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n d\u01b0\u1edbi 18 tu\u1ed5i.<\/p>\n<p><strong>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>Qu\u00e1 m\u1eabn v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n<p>Ch\u1ea3y m\u00e1u do b\u1ec7nh l\u00fd \u0111ang ho\u1ea1t \u0111\u1ed9ng nh\u01b0 ch\u1ea3y m\u00e1u d\u1ea1 d\u00e0y t\u00e1 tr\u00e0ng, xu\u1ea5t huy\u1ebft v\u00f5ng m\u1ea1c ho\u1eb7c trong n\u1ed9i s\u1ecd.<\/p>\n<p>Ph\u1ee5 n\u1eef \u0111ang cho con b\u00fa.<\/p>\n<p>B\u1ec7nh nh\u00e2n suy gan n\u1eb7ng.<\/p>\n<p><strong>4.4 Th\u1eadn tr\u1ecdng:<\/strong><\/p>\n<p>B\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 ch\u1ea9y m\u00e1u do ch\u1ea5n th\u01b0\u01a1ng, ph\u1eabu thu\u1eadt ho\u1eb7c c\u00e1c b\u1ec7nh l\u00fd ch\u1ea3y m\u00e1u kh\u00e1c. N\u00ean ng\u01b0ng s\u1eed d\u1ee5ng thu\u1ed1c 7 ng\u00e0y tr\u01b0\u1edbc khi ph\u1eabu thu\u1eadt.<\/p>\n<p>Ng\u01b0\u1eddi b\u1ec7nh d\u00f9ng thu\u1ed1c d\u00e0i h\u1ea1n h\u01a1n b\u00ecnh th\u01b0\u1eddng ph\u1ea3i ng\u01b0ng d\u00f9ng thu\u1ed1c khi c\u00f3 ch\u1ea9y m\u00e1u b\u1ea5t th\u01b0\u1eddng v\u00e0 b\u00e1o ngay cho B\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>C\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng cho b\u1ec7nh nh\u00e2n suy th\u1eadn, suy gan v\u00e0 ph\u1ee5 n\u1eef mang thai.<\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>Clopidogrel kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i t\u00e0u xe hay v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n<p><strong>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/strong><\/p>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: B1<\/p>\n<p>US FDA pregnancy category: B<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>Th\u1ef1c nghi\u1ec7m tr\u00ean th\u1ecf v\u00e0 chu\u1ed9t kh\u00f4ng th\u1ea5y \u1ea3nh h\u01b0\u1edfng c\u1ee7a clopidogrel g\u00e2y \u0111\u1ed9c t\u00ednh cho thai nhi. Tuy nhi\u00ean ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u n\u00e0o ti\u1ebfn h\u00e0nh tr\u00ean ph\u1ee5 n\u1eef c\u00f3 thai. Do \u0111\u00f3, ch\u1ec9 s\u1eed d\u1ee5ng clopidogrel cho nh\u1eefng ph\u1ee5 n\u1eef c\u00f3 thai khi th\u1eadt c\u1ea7n thi\u1ebft.<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>Th\u1ef1c nghi\u1ec7m tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y clopidogrel v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua s\u1eefa. Cho \u0111\u1ebfn nay, ch\u01b0a c\u00f3 th\u00f4ng tin cho bi\u1ebft clopidogrel c\u00f3 b\u00e0i ti\u1ebft qua s\u1eefa m\u1eb9 hay kh\u00f4ng. Do \u0111\u00f3 c\u1ea7n c\u00e2n nh\u1eafc vi\u1ec7c ng\u1eebng cho con b\u00fa trong th\u1eddi gian d\u00f9ng clopidogrel ho\u1eb7c ng\u1eebng clopidogrel t\u00f9y thu\u1ed9c v\u00e0o m\u1ee9c \u0111\u1ed9 c\u1ea7n thi\u1ebft ph\u1ea3i d\u00f9ng thu\u1ed1c \u1edf ng\u01b0\u1eddi m\u1eb9 \u0111ang cho con b\u00fa.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/strong><\/p>\n<p>Xu\u1ea5t huy\u1ebft ti\u00eau h\u00f3a, t\u1ee5 m\u00e1u, ch\u1ea3y m\u00e1u cam, xu\u1ea5t huy\u1ebft n\u1ed9i s\u1ecd, ti\u1ec3u ra m\u00e1u, ch\u1ea3y m\u00e1u m\u1eaft, \u0111au b\u1ee5ng, ch\u00e1n \u0103n, ti\u00eau ch\u1ea3y, bu\u1ed3n n\u00f4n, vi\u00eam d\u1ea1 d\u00e0y, n\u1ed5i m\u1eabn, ng\u1ee9a.<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<p><strong>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/strong><\/p>\n<p>Theo d\u00f5i \u0111\u1ecbnh k\u1ef3 c\u00e1c th\u00f4ng s\u1ed1 c\u00e1c d\u1ea5u hi\u1ec7u thi\u1ebfu m\u00e1u, hemoglobin, hematocrit trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb b\u1eb1ng clopidogrel.<\/p>\n<p>Thay huy\u1ebft t\u01b0\u01a1ng c\u1ea5p c\u1ee9u trong tr\u01b0\u1eddng h\u1ee3p xu\u1ea5t huy\u1ebft gi\u1ea3m ti\u1ec3u c\u1ea7u.<\/p>\n<p><strong>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/strong><\/p>\n<p>C\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng Clopidogrel ph\u1ed1i h\u1ee3p v\u1edbi Asipirin, thu\u1ed1c kh\u00e1ng vi\u00eam kh\u00f4ng steroid, heparin, thu\u1ed1c tan huy\u1ebft kh\u1ed1i v\u00ec c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m t\u0103ng nguy c\u01a1 ch\u1ea3y m\u00e1u.<\/p>\n<p>Kh\u00f4ng n\u00ean d\u00f9ng k\u1ebft h\u1ee3p Clopidogrel v\u1edbi Wafarin v\u00ec n\u00f3 c\u00f3 th\u1ec3 l\u00e0m t\u0103ng m\u1ee9c \u0111\u1ed9 ch\u1ea3y m\u00e1u.<\/p>\n<p>Clopidogrel \u1ee9c ch\u1ebf cytochrom P450 CYP2C19 n\u00ean s\u1ebd \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn nh\u1eefng thu\u1ed1c chuy\u1ec3n h\u00f3a b\u1edfi enzym n\u00e0y: Phenylyoin, Corticoid, Propanolol,&#8230;<\/p>\n<p>M\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y cho th\u1ea5y c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton (PPIs) l\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng ng\u0103n c\u1ea7n s\u1ef1 k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u c\u1ee7a Clopidogrel, tuy nhi\u00ean v\u1eabn ch\u01b0a c\u00f3 b\u1eb1ng ch\u1ee9ng r\u00f5 r\u00e0ng v\u1ec1 s\u1ef1 t\u01b0\u01a1ng t\u00e1c n\u00e0y, do \u0111\u00f3 ch\u1ec9 n\u00ean k\u1ebft h\u1ee3p 2 lo\u1ea1i thu\u1ed1c n\u00e0y khi th\u1eadt s\u1ef1 c\u1ea7n thi\u1ebft.<\/p>\n<p><strong>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/strong><\/p>\n<p>\u1ede ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh t\u00ecnh nguy\u1ec7n, kh\u00f4ng th\u1ea5y c\u00f3 t\u00e1c d\u1ee5ng ph\u1ee5 n\u00e0o \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o khi d\u00f9ng li\u1ec1u duy nh\u1ea5t 600 mg Clopidogrel (t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi 8 vi\u00ean 75 mg). Th\u1eddi gian ch\u1ea3y m\u00e1u t\u0103ng l\u00ean 1,7 l\u1ea7n so v\u1edbi d\u00f9ng li\u1ec1u 75 mg\/ng\u00e0y.<\/p>\n<p>C\u00e1c bi\u1ec3u hi\u1ec7n ng\u1ed9 \u0111\u1ed9c c\u1ea5p t\u00ednh: N\u00f4n m\u1eeda, ki\u1ec7t s\u1ee9c, kh\u00f3 th\u1edf v\u00e0 ch\u1ea3y m\u00e1u \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/p>\n<p>C\u00e1ch x\u1eed tr\u00ed: hi\u1ec7n ch\u01b0a c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c Clopidogrel, d\u1ef1a tr\u00ean c\u01a1 s\u1edf sinh h\u1ecdc \u0111\u00e1ng tin c\u1eady,truy\u1ec1n ti\u1ec3u c\u1ea7u k\u1ecbp th\u1eddi c\u00f3 th\u1ec3 l\u00e0m \u0111\u1ea3o ng\u01b0\u1ee3c t\u00e1c \u0111\u1ed9ng d\u01b0\u1ee3c h\u1ecdc c\u1ee7a Clopidogrel<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/strong><\/p>\n<p><strong>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/strong><\/p>\n<p>Clopidogrel l\u00e0 thu\u1ed1c ch\u1ed1ng k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u, t\u00e1c \u0111\u1ed9ng b\u1eb1ng s\u1ef1 bi\u1ebfn \u0111\u1ed5i kh\u00f4ng h\u1ed3i ph\u1ee5c th\u1ee5 th\u1ec3 ADP ti\u1ec3u c\u1ea7u. Ti\u1ec3u c\u1ea7u l\u00e0 t\u1ebf b\u00e0o m\u00e1u c\u00f3 t\u00ednh k\u1ebft d\u00ednh gi\u00fap th\u00e0nh l\u1eadp huy\u1ebft kh\u1ed1i v\u00e0 g\u00f3p ph\u1ea7n v\u00e0o ngh\u1ebdn \u0111\u1ed9ng m\u1ea1ch v\u00e0nh. Nh\u1edd v\u00e0o t\u00e1c d\u1ee5ng ng\u0103n ng\u1eeba s\u1ef1 k\u1ebft d\u00ednh ti\u1ec3u c\u1ea7u, Clopidogrel l\u00e0m gi\u1ea3m nguy c\u01a1 th\u00e0nh l\u1eadp c\u1ee5c m\u00e1u \u0111\u00f4ng (huy\u1ebft kh\u1ed1i) trong l\u00f2ng m\u1ea1ch m\u00e1u b\u1ecb x\u01a1 c\u1ee9ng (x\u01a1 v\u1eefa \u0111\u1ed9ng m\u1ea1ch). T\u1eeb \u0111\u00f3 l\u00e0m gi\u1ea3m c\u00e1c bi\u1ebfn c\u1ed1 do huy\u1ebft kh\u1ed1i nh\u01b0: Nh\u1ed3i m\u00e1u c\u01a1 tim, tai bi\u1ebfn m\u1ea1ch m\u00e1u n\u00e3o, t\u1eed vong\u2026..<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>Clopidogrel l\u00e0 m\u1ed9t ti\u1ec1n ch\u1ea5t, m\u1ed9t trong c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a ho\u1ea1t \u0111\u1ed9ng c\u1ee7a n\u00f3 l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf ng\u01b0ng t\u1eadp ti\u1ec3u c\u1ea7u. Clopidogrel ph\u1ea3i \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1edfi enzym CYP2C19 \u0111\u1ec3 t\u1ea1o th\u00e0nh ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh \u1ee9c ch\u1ebft \u0111\u01b0\u1ee3c ng\u01b0ng t\u1eadp ti\u1ec3u c\u1ea7u. Ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1ea1t t\u00ednh c\u1ee7a clopidogrel \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc l\u00ean v\u1ecb tr\u00ed g\u1eafn c\u1ee7a adenosine diphosphate (ADP) t\u1ea1i th\u1ee5 th\u1ec3 P2Y<sub>12\u00a0<\/sub>v\u1ed1n l\u00e0 v\u1ecb tr\u00ed t\u1ea1o ra s\u1ef1 ho\u1ea1t h\u00f3a ph\u1ee9c h\u1ee3p glycoprotein GPIIb\/IIIa qua trung gian ADP, do v\u1eady m\u00e0 \u1ee9c ch\u1ebf k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u. Do s\u1ef1 g\u1eafn k\u1ebft n\u00e0y l\u00e0 kh\u00f4ng h\u1ed3i ph\u1ee5c, c\u00e1c ti\u1ec3u c\u1ea7u \u0111\u00e3 g\u1eafn k\u1ebft v\u1edbi thu\u1ed1c s\u1ebd ch\u1ecbu \u1ea3nh h\u01b0\u1edfng trong su\u1ed1t \u0111\u1eddi s\u1ed1ng c\u00f2n l\u1ea1i c\u1ee7a ti\u1ec3u c\u1ea7u (tu\u1ed5i th\u1ecd c\u1ee7a ti\u1ec3u c\u1ea7u l\u00e0 kho\u1ea3ng g\u1ea7n 7-10 ng\u00e0y) v\u00e0 t\u1ed1c \u0111\u1ed9 h\u1ed3i ph\u1ee5c ch\u1ee9c n\u0103ng c\u1ee7a ti\u1ec3u c\u1ea7u v\u1ec1 b\u00ecnh th\u01b0\u1eddng x\u1ea3y ra tr\u00f9ng v\u1edbi t\u1ed1c \u0111\u1ed9 s\u1ea3n sinh ti\u1ec3u c\u1ea7u. S\u1ef1 ng\u01b0ng t\u1eadp ti\u1ec3u c\u1ea7u g\u00e2y ra do c\u00e1c ch\u1ea5t \u0111\u1ed3ng v\u1eadn kh\u00e1c kh\u00f4ng ph\u1ea3i ADP c\u0169ng b\u1ecb \u1ee9c ch\u1ebf b\u1eb1ng c\u00e1ch ch\u1eb9n s\u1ef1 khu\u1ebfch \u0111\u1ea1i c\u1ee7a ho\u1ea1t h\u00f3a ti\u1ec3u c\u1ea7u do vi\u1ec7c ph\u00f3ng th\u00edch ADP.<\/p>\n<p>Do ch\u1ea5t chuy\u1ec3n h\u00f3a ho\u1ea1t \u0111\u1ed9ng \u0111\u01b0\u1ee3c th\u00e0nh l\u1eadp t\u1eeb men CYP450, m\u1ed9t s\u1ed1 c\u00e1c men n\u00e0y l\u00e0 \u0111a h\u00ecnh hay \u0111\u1ed1i t\u01b0\u1ee3ng \u1ee9c ch\u1ebf c\u1ee7a thu\u1ed1c kh\u00e1c, n\u00ean kh\u00f4ng ph\u1ea3i t\u1ea5t c\u1ea3 b\u1ec7nh nh\u00e2n \u0111\u1ec1u s\u1ebd \u0111\u01b0\u1ee3c \u1ee9c ch\u1ebf ti\u1ec3u c\u1ea7u th\u00edch \u0111\u00e1ng.<\/p>\n<p><a href=\"https:\/\/www.youtube.com\/watch?v=Km6TTc9GQuU\"><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/a><\/p>\n<p><strong>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/strong><\/p>\n<p>Clopidogrel l\u00e0 d\u1ea1ng ti\u1ec1n ch\u1ea5t, sau khi d\u00f9ng li\u1ec1u u\u1ed1ng l\u1eb7p l\u1ea1i 75 mg\/ng\u00e0y Clopidogrel nhanh ch\u00f3ng \u0111\u01b0\u1ee3c h\u1ea5p thu v\u00e0 chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu \u1edf gan th\u00e0nh hai d\u1ea1ng l\u00e0 d\u1ea1ng c\u00f3 ho\u1ea1t t\u00ednh (c\u00e1c d\u1eabn ch\u1ea5t Thiol) v\u00e0 d\u1ea1ng kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh (c\u00e1c d\u1eabn xu\u1ea5t c\u1ee7a Acid Carboxylic).<\/p>\n<p>Ch\u1ea5t chuy\u1ec3n h\u00f3a Thiol g\u1eafn k\u1ebft nhanh ch\u00f3ng v\u00e0 kh\u00f4ng h\u1ed3i ph\u1ee5c v\u1edbi c\u00e1c th\u1ee5 th\u1ec3 ADP ti\u1ec3u c\u1ea7u. C\u00e1c d\u1eabn xu\u1ea5t Acid Carboxylic chi\u1ebfm kho\u1ea3ng 85% th\u00e0nh ph\u1ea7n thu\u1ed1c chuy\u1ec3n h\u00f3a l\u01b0u h\u00e0nh trong huy\u1ebft t\u01b0\u01a1ng.<\/p>\n<p>Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a ch\u1ea5t chuy\u1ec3n h\u00f3a l\u01b0u h\u00e0nh ch\u00ednh l\u00e0 8 gi\u1edd sau khi d\u00f9ng li\u1ec1u duy nh\u1ea5t v\u00e0 li\u1ec1u l\u1eb7p l\u1ea1i. Clopidogrel v\u00e0 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a n\u00f3 b\u00e0i ti\u1ebft qua ph\u00e2n v\u00e0 \u0111\u01b0\u1eddng ti\u1ec3u, 50% li\u1ec1u d\u00f9ng \u0111\u01b0\u1ee3c gi\u1eef l\u1ea1i trong n\u01b0\u1edbc ti\u1ec3u v\u00e0 46% \u0111\u01b0\u1ee3c gi\u1eef l\u1ea1i trong ph\u00e2n.<\/p>\n<p><strong>5.3 Gi\u1ea3i th\u00edch: <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong>5.4 Thay th\u1ebf thu\u1ed1c : <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/strong><\/p>\n<p><strong>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/strong><\/p>\n<p>T\u00e1 d\u01b0\u1ee3c: Lactose, Polyvinyl Pyrrolidon K30, Avicel pH 101, Natri Starch Glycolat, Magnesi Stearat, Aerosil, Hydroxypropyl Methylcellulose 606, Hydroxypropyl Methylcellulose 615, Titan Dioxyd, Talc, Ponceau 4R, \u0111\u1ecf Oxyd s\u1eaft, Polyethylen Glycol 6000.<\/p>\n<p><strong>6.2. T\u01b0\u01a1ng k\u1ef5 :<\/strong><\/p>\n<p>Kh\u00f4ng \u00e1p d\u1ee5ng.<\/p>\n<p><strong>6.3. B\u1ea3o qu\u1ea3n: <\/strong><\/p>\n<p>N\u01a1i kh\u00f4, tr\u00e1nh \u00e1nh s\u00e1ng, nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30\u00b0C.<\/p>\n<p><strong>6.4. Th\u00f4ng tin kh\u00e1c :<\/strong><\/p>\n<p>Kh\u00f4ng c\u00f3.<\/p>\n<p><strong>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/strong><\/p>\n<p>D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Clopidogrel Ph\u00e2n lo\u1ea1i: Thu\u00f4\u0301c ch\u00f4\u0301ng \u0111\u00f4ng va\u0300 la\u0300m tan huy\u00ea\u0301t kh\u00f4\u0301i, Thu\u1ed1c \u1ee9c ch\u1ebf k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u. Nh\u00f3m ph\u00e1p l\u00fd: Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine) M\u00e3 ATC (Anatomical Therapeutic Chemical): B01AC04. Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c: PLAVIX Bi\u1ec7t d\u01b0\u1ee3c: [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":19372,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[657],"class_list":["post-19371","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-clopidogrel"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/19371","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=19371"}],"version-history":[{"count":3,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/19371\/revisions"}],"predecessor-version":[{"id":49975,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/19371\/revisions\/49975"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/19372"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=19371"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=19371"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=19371"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}