{"id":18944,"date":"2020-05-31T23:10:58","date_gmt":"2020-05-31T16:10:58","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=18944"},"modified":"2025-01-08T20:59:17","modified_gmt":"2025-01-08T13:59:17","slug":"cycloserine-pulcyclo","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/cycloserine-pulcyclo\/","title":{"rendered":"Cycloserine &#8211; Pulcyclo"},"content":{"rendered":"<p><strong>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: <\/strong><\/p>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <a href=\"https:\/\/pharmog.com\/wp\/cycloserine\/\">Cycloserine<\/a><\/strong><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u1ed1c kh\u00e1ng sinh d\u1eabn xu\u1ea5t Streptomyces<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): J04AB01.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em><\/strong><\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c:<\/em><\/strong> Pulcyclo<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c ph\u1ea9m Me Di Sun<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng: <\/strong><\/p>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>Vi\u00ean nang 250 mg..<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>PULCYCLO<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean nang c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Cycloserine<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>250 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"503\" height=\"501\" class=\"wp-image-18945\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-434.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-434.png 503w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-434-150x150.png 150w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-434-300x300.png 300w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-434-161x160.png 161w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-434-60x60.png 60w\" sizes=\"auto, (max-width: 503px) 100vw, 503px\" \/><\/p>\n<p><strong>3. Video by Pharmog:<\/strong><\/p>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe loading=\"lazy\" title=\"[Pharmog SS1 - T\u1eadp 08] - D\u01b0\u1ee3c l\u00fd c\u00e1c thu\u1ed1c kh\u00e1ng sinh\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/0TIIfoiJFwA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<p><strong>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng: <\/strong><\/p>\n<p><strong>4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>PULCYCLO \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh lao kh\u00e1ng thu\u1ed1c (d\u00f9ng k\u1ebft h\u1ecdp v\u1edbi c\u00e1c thu\u1ed1c ch\u1ed1ng lao, c\u00e1c bi\u1ec7n ph\u00e1p h\u00f3a tr\u1ecb li\u1ec7u kh\u00e1c) nh\u01b0: lao ph\u1ed5i, lao ngo\u00e0i ph\u1ed5i (bao g\u1ed3m c\u1ea3 th\u1eadn) g\u00e2y do c\u00e1c vi khu\u1ea9n m\u1eabn c\u1ea3m sau khi \u0111\u00e3 \u0111i\u1ec1u tr\u1ecb \u0111\u00e3 \u0111i\u1ec1u tr\u1ecb th\u1ea5t b\u1ea1i b\u1eb1ng c\u00e1c lo\u1ea1i thu\u1ed1c c\u0103n b\u1ea3n kh\u00e1c.<\/p>\n<p>Nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng &#8211; ni\u1ec7u do c\u00e1c ch\u1ee7ng Gram \u00e2m v\u00e0 gram d\u01b0\u01a1ng, \u0111\u1eb7c bi\u1ec7t l\u00e0 Enterobacter sp. (ch\u1ec9 d\u00f9ng khi c\u00e1c thu\u1ed1c kh\u00e1c \u00edt hi\u1ec7u qu\u1ea3 h\u01a1n, \u00edt \u0111\u1ed9c h\u01a1n v\u00e0 vi khu\u1ea9n g\u00e2y b\u1ec7nh \u0111\u01b0\u1ee3c ch\u1ee9ng minh c\u00f3 nh\u1ea1y c\u1ea3m v\u1edbi cycloserin).<\/p>\n<p><strong>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/strong><\/p>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p>D\u00f9ng theo \u0111\u01b0\u1eddng u\u1ed1ng, k\u1ebft h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c ch\u1ed1ng lao kh\u00e1c \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb lao.<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p>Ng\u01b0\u1eddi l\u1edbn: B\u1eaft \u0111\u1ea7u 250 mg\/l\u1ea7n, 12 gi\u1edd m\u1ed9t l\u1ea7n, trong 2 tu\u1ea7n \u0111\u1ea7u sau \u0111\u00f3 th\u1eadn tr\u1ecdng t\u0103ng li\u1ec1u, n\u1ebfu c\u1ea7n, theo n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u \u0111\u1ebfn khi c\u00f3 \u0111\u00e1p \u1ee9ng, cho \u0111\u1ebfn t\u1ed1i \u0111a 500 mg m\u1ed7i 12 gi\u1edd (li\u1ec1u h\u00e0ng ng\u00e0y cao nh\u1ea5t 15-20 mg\/kg).<\/p>\n<p>Tr\u1ebb em: B\u1eaft \u0111\u1ea7u 10 mg\/kg th\u1ec3 tr\u1ecdng m\u1ed9t ng\u00e0y v\u00e0 \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u theo n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u v\u00e0 \u0111\u00e1p \u1ee9ng c\u1ee7a thu\u1ed1c.<\/p>\n<p>Ch\u00fa \u00fd: Ph\u1ea3i theo d\u00f5i n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u, \u0111\u1eb7c bi\u1ec7t \u0111\u1ed1i v\u1edbi ng\u01b0\u1eddi suy th\u1eadn ho\u1eb7c khi d\u00f9ng li\u1ec1u v\u01b0\u1ee3t qu\u00e1 500 mg\/ng\u00e0y ho\u1eb7c c\u00f3 d\u1ea5u hi\u1ec7u ng\u1ed9 \u0111\u1ed9c. N\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u kh\u00f4ng \u0111\u01b0\u1ee3c v\u01b0\u1ee3t qu\u00e1 30 microgam\/ml. Ng\u01b0\u1eddi b\u1ec7nh suy th\u1eadn (\u0111\u1ed9 thanh th\u1ea3i creatinin &lt; 50 ml\/ph\u00fat {0,83 ml\/gi\u00e2y}) kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng cycloserin do t\u0103ng nguy c\u01a1 ng\u1ed9 \u0111\u1ed9c th\u1ea7n kinh.<\/p>\n<p><strong>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>Qu\u00e1 m\u1eabn v\u1edbi cycloserin, \u0111\u1ed9ng kinh, tr\u1ea7m c\u1ea3m, lo \u00e2u n\u1eb7ng, lo\u1ea1n t\u00e2m th\u1ea7n, suy th\u1eadn n\u1eb7ng, nghi\u1ec7n r\u01b0\u1ee3u.<\/p>\n<p><strong>4.4 Th\u1eadn tr\u1ecdng:<\/strong><\/p>\n<p>C\u1ea7n theo d\u00f5i s\u00e1t ng\u01b0\u1eddi b\u1ec7nh trong 2 tu\u1ea7n \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb khi d\u00f9ng 500 mg cycloserin\/ng\u00e0y v\u00ec kho\u1ea3ng 30% ng\u01b0\u1eddi b\u1ec7nh c\u00f3 tai bi\u1ebfn ph\u1ee5 v\u1ec1 th\u1ea7n kinh, c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u sao cho n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u lu\u00f4n d\u01b0\u1edbi 30 microgam\/ml, ng\u1ed9 \u0111\u1ed9c cycloserin li\u00ean quan ch\u1eb7t ch\u1ebd t\u1edbiln\u1ed3ng \u0111\u1ed9 thu\u1ed1c qu\u00e1 nhi\u1ec1u trong m\u00e1u (tr\u00ean 30 microgam\/ml).<\/p>\n<p>C\u00e1c x\u00e9t nghi\u1ec7m v\u1ec1 gan, th\u1eadn v\u00e0 huy\u1ebft h\u1ecdc ph\u1ea3i \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb b\u1eb1ng cycloserin. Ph\u1ea3i gi\u1ea3m li\u1ec1u v\u00e0\/ho\u1eb7c s\u1ed1 l\u1ea7n d\u00f9ng thu\u1ed1c \u1edf ng\u01b0\u1eddi b\u1ec7nh suy th\u1eadn, khi c\u00f3 c\u00e1c tri\u1ec7u ch\u1ee9ng nhi\u1ec5m \u0111\u1ed9c c\u1ea5p.<\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>Thu\u1ed1c c\u00f3 th\u1ebf g\u00e2y ng\u1ee7 g\u00e0, \u0111au \u0111\u1ea7u, k\u00edch th\u00edch, do \u0111\u00f3 kh\u00f4ng n\u00ean l\u00e1i xe, v\u1eadn h\u00e0nh m\u00e1y m\u00f3c hay l\u00e0m c\u00e1c c\u00f4ng vi\u1ec7c \u0111\u00f2i h\u1ecfi t\u1eadp trung cao khi \u0111ang d\u00f9ng thu\u1ed1c.<\/p>\n<p><strong>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/strong><\/p>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: NA<\/p>\n<p>US FDA pregnancy category: C<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>Ch\u1ec9 d\u00f9ng khi th\u1eadt c\u1ea7n thi\u1ebft.<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>Do ti\u1ec1m n\u0103ng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n c\u1ee7a cycloserin \u1edf tr\u1ebb \u0111ang b\u00fa m\u1eb9, v\u00ec v\u1eady n\u00ean cho tr\u1ebb ng\u1eebng b\u00fa khi ng\u01b0\u1eddi m\u1eb9 c\u1ea7n thi\u1ebft ph\u1ea3i d\u00f9ng cycloserin.<\/p>\n<p><strong>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/strong><\/p>\n<p>C\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n th\u01b0\u1eddng g\u1eb7p nh\u1ea5t thu\u1ed9c h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng, th\u01b0\u1eddng xu\u1ea5t hi\u1ec7n nhi\u1ec1u v\u00e0o 2 tu\u1ea7n \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb v\u00e0 m\u1ea5t \u0111i khi ng\u1eebng thu\u1ed1c. C\u00e1c bi\u1ec3u hi\u1ec7n th\u01b0\u1eddng th\u1ea5y l\u00e0 ng\u1ee7 g\u00e0, \u0111au \u0111\u1ea7u, run r\u1ea5y, lo\u1ea1n v\u1eadn ng\u00f4n, ch\u00f3ng m\u1eb7t, l\u00fa l\u1eabn, h\u1ed1t ho\u1ea3ng, k\u00edch th\u00edch, tr\u1ea1ng th\u00e1i t\u00e2m th\u1ea7n, c\u00f3 \u00fd \u0111\u1ecbnh t\u1ef1 t\u1eed, hoang t\u01b0\u1edfng, ph\u1ea3n \u1ee9ng gi\u1ea3m tr\u01b0\u01a1ng l\u1ef1c, co gi\u1eadt c\u01a1, rung gi\u1eadt, t\u0103ng ph\u1ea3n x\u1ea1, lo\u1ea1n th\u1ecb, li\u1ec7t nh\u1eb9, c\u01a1n co c\u1ee9ng gi\u1eadt rung ho\u1eb7c v\u1eafng \u00fd th\u1ee9c. D\u00f9ng li\u1ec1u cao cycloserin ho\u1eb7c u\u1ed1ng r\u01b0\u1ee3u trong khi \u0111i\u1ec1u tr\u1ecb s\u1ebd l\u00e0m t\u0103ng nguy c\u01a1 co gi\u1eadt. R\u1ea5t hi\u1ebfm g\u1eb7p vi\u00eam gan.<\/p>\n<p><em>Th\u01b0\u1eddng g\u1eb7p, ADR &gt; 1\/100<\/em><\/p>\n<p>Th\u1ea7n kinh trung \u01b0\u01a1ng: \u0110au \u0111\u1ea7u, hoa m\u1eaft, lo \u00e2u, ch\u00f3ng m\u1eb7t, ng\u1ee7 g\u00e0, run r\u1ea5y, co gi\u1eadt, tr\u1ea7m c\u1ea3m.<\/p>\n<p><em>\u00cdt g\u1eb7p, 1\/1 000 &lt; ADR &lt; 1\/100<\/em><\/p>\n<p>Th\u1ea7n kinh trung \u01b0\u01a1ng: Thay \u0111\u1ed5i t\u00e2m th\u1ea7n, thay \u0111\u1ed5i nh\u00e2n c\u00e1ch, k\u00edch th\u00edch, hung d\u1eef.<\/p>\n<p><em>Hi\u1ebfm g\u1eb7p, ADR &lt;1\/1 000<\/em><\/p>\n<p>Da: Ban \u0111\u1ecf.<\/p>\n<p>M\u00e1u: Thi\u1ebfu m\u00e1u nguy\u00ean h\u1ed3ng c\u1ea7u kh\u1ed5ng l\u1ed3, thi\u1ebfu m\u00e1u nguy\u00ean h\u1ed3ng c\u1ea7u nhi\u1ec5m s\u1eaft.<\/p>\n<p>Chuy\u1ec3n h\u00f3a: Gi\u1ea3m h\u1ea5p thu calci, magnesi; gi\u1ea3m t\u1ed5ng h\u1ee3p protein.<\/p>\n<p>T\u00e1c d\u1ee5ng kh\u00e1c: Thi\u1ebfu vitamin B<sub>12<\/sub>, thi\u1ebfu acid folic, lo\u1ea1n nh\u1ecbp tim.<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<p><strong>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/strong><\/p>\n<p>C\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng s\u1ebd gi\u1ea3m nh\u1eb9 n\u1ebfu n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u kh\u00f4ng qu\u00e1 30 microgam\/ml. N\u1ebfu c\u00f3 c\u00e1c tri\u1ec7u ch\u1ee9ng ng\u1ed9 \u0111\u1ed9c th\u1ea7n kinh, c\u1ea7n gi\u1ea3m li\u1ec1u ho\u1eb7c ng\u1eebng thu\u1ed1c. C\u00f3 th\u1ec3 gi\u1ea3m nh\u1eb9 ho\u1eb7c ph\u00f2ng tr\u00e1nh m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ng\u1ed9 \u0111\u1ed9c th\u1ea7n kinh b\u1eb1ng c\u00e1ch d\u00f9ng k\u1ebft h\u1ee3p v\u1edbi 100 &#8211; 300 mg pyridoxin hydroclorid h\u00e0ng ng\u00e0y, chia nh\u1ecf li\u1ec1u.<\/p>\n<p>D\u00f9ng c\u00e1c thu\u1ed1c ch\u1ed1ng co gi\u1eadt v\u00e0 an th\u1ea7n \u0111\u1ec3 gi\u1ea3m co gi\u1eadt v\u00e0 tr\u1ea1ng th\u00e1i lo l\u1eafng, run r\u1ea9y.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/strong><\/p>\n<p>Cycloserin l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng c\u1ee7a r\u01b0\u1ee3u v\u00e0 phenytoin. T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n c\u1ee7a cycloserin \u0111\u1ed1i v\u1edbi h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng t\u0103ng l\u00ean khi d\u00f9ng ph\u1ed1i h\u1ecdp v\u1edbi isoniazid v\u00e0 ethionamid.<\/p>\n<p>Cycloserin c\u00f3 t\u00ednh \u0111\u1ed1i kh\u00e1ng v\u1edbi pyridoxin v\u00e0 l\u00e0m t\u0103ng th\u1ea3i tr\u1eeb pyridoxin \u1edf th\u1eadn; nhu c\u1ea7u v\u1ec1 pyridoxin c\u00f3 th\u1ec3 t\u0103ng \u1edf ng\u01b0\u1eddi b\u1ec7nh d\u00f9ng cycloserin<\/p>\n<p><strong>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/strong><\/p>\n<p><em>Tri\u1ec7u ch\u1ee9ng:<\/em> \u0110au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, l\u00fa l\u1eabn, ng\u1ee7 g\u00e0, t\u0103ng k\u00edch th\u00edch, d\u1ecb c\u1ea3m, lo\u1ea1n v\u1eadn ng\u00f4n v\u00e0 t\u00e2m th\u1ea7n. Li\u1ec7t nh\u1eb9, co gi\u1eadt, v\u00e0 h\u00f4n m\u00ea c\u00f3 th\u1ec3 x\u1ea3y ra khi d\u00f9ng qu\u00e1 li\u1ec1u cycloserin nhi\u1ec1u.<\/p>\n<p><em>X\u1eed tr\u00ed:<\/em> G\u00e2y n\u00f4n v\u00e0\/ho\u1eb7c r\u1eeda d\u1ea1 d\u00e0y.<\/p>\n<p>D\u00f9ng than ho\u1ea1t v\u00e0 thu\u1ed1c x\u1ed5 4 gi\u1edd m\u1ed9t l\u1ea7n cho \u0111\u1ebfn khi t\u00ecnh tr\u1ea1ng \u1ed5n \u0111\u1ecbnh.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3: D\u00f9ng thu\u1ed1c ch\u1ed1ng co gi\u1eadt \u0111\u1ec3 ki\u1ec3m so\u00e1t co gi\u1eadt. D\u00f9ng 200 &#8211; 300 mg pyridoxin hydroclorid h\u00e0ng ng\u00e0y chia nhi\u1ec1u l\u1ea7n \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ng\u1ed9 \u0111\u1ed9c th\u1ea7n kinh.<\/p>\n<p><strong>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/strong><\/p>\n<p><strong>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/strong><\/p>\n<p>Cycloserin l\u00e0 kh\u00e1ng sinh t\u00e1ch ra t\u1eeb Streptomyces orchidaceus ho\u1eb7c Streptomyces garyphalus v\u00e0 c\u0169ng \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p t\u1ed5ng h\u1ee3p h\u00f3a h\u1ecdc. Thu\u1ed1c c\u00f3 c\u1ea5u tr\u00fac gi\u1ed1ng acid amin D-alanin, v\u00ec th\u1ebf cycloserin \u1ee9c ch\u1ebf c\u00e1c ph\u1ea3n \u1ee9ng trong \u0111\u00f3 D-alanin tham gia t\u1ed5ng h\u1ee3p v\u1ecf t\u1ebf b\u00e0o vi khu\u1ea9n. Trong m\u00f4i tr\u01b0\u1eddng kh\u00f4ng c\u00f3 D-alanin, cycloserin \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n c\u00e1c ch\u1ee7ng Enterococcus, Escherichia coli, Staphylococcus aureus, Nocardia v\u00e0 Chlamydia in vitro. Cycloserin c\u00f3 t\u00e1c d\u1ee5ng k\u00ecm khu\u1ea9n hay di\u1ec7t khu\u1ea9n t\u00f9y theo n\u1ed3ng \u0111\u1ed9 c\u1ee7a thu\u1ed1c t\u1ea1i v\u1ecb tr\u00ed t\u1ed5n th\u01b0\u01a1ng v\u00e0 t\u00ednh nh\u1ea1y c\u1ea3m c\u1ee7a vi khu\u1ea9n g\u00e2y b\u1ec7nh. \u1ede n\u1ed3ng \u0111\u1ed9 5 \u0111\u1ebfn 30 microgam\/ ml, cycloserin \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n Mycobacterium tuberculosis in vitro. Kh\u00f4ng c\u00f3 s\u1ef1 kh\u00e1ng ch\u00e9o gi\u1eefa cycloserin v\u1edbi c\u00e1c thu\u1ed1c ch\u1eefa lao kh\u00e1c.<\/p>\n<p>Ng\u01b0\u1eddi ta \u0111\u00e3 th\u1ea5y c\u00f3 hi\u1ec7n t\u01b0\u1ee3ng kh\u00e1ng thu\u1ed1c t\u1ef1 nhi\u00ean v\u00e0 m\u1eafc ph\u1ea3i \u0111\u1ed1i v\u1edbi cycloserin c\u1ee7a ch\u1ee7ng Mycobacterium tuberculosis trong ph\u00f2ng th\u00ed nghi\u1ec7m v\u00e0 tr\u00ean l\u00e2m s\u00e0ng. C\u00e1c ch\u1ee7ng Mycobacterium tuberculosis l\u00fac \u0111\u1ea7u nh\u1ea1y c\u1ea3m v\u1edbi thu\u1ed1c, kh\u00e1ng thu\u1ed1c r\u1ea5t nhanh khi s\u1eed d\u1ee5ng \u0111\u01a1n \u0111\u1ed9c cycloserin trong \u0111i\u1ec1u tr\u1ecb. K\u1ebft h\u1ee3p cycloserin v\u1edbi c\u00e1c thu\u1ed1c ch\u1ed1ng lao kh\u00e1c, c\u00f3 th\u1ec3 gi\u1ea3m v\u00e0 ph\u00f2ng tr\u00e1nh \u0111\u01b0\u1ee3c s\u1ef1 kh\u00e1ng thu\u1ed1c. Cycloserin khi ph\u1ed1i h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c h\u00e0ng \u0111\u1ea7u ch\u1ed1ng lao kh\u00e1c (streptomycin, isoniazid, rifampicin, ethambutol, pyrazynamid) \u0111\u00e3 c\u00f3 t\u00e1c d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb lao kh\u00e1ng thu\u1ed1c. V\u00ec t\u00ecnh h\u00ecnh kh\u00e1ng thu\u1ed1c \u0111ang lan r\u1ed9ng tr\u00ean th\u1ebf gi\u1edbi n\u00ean c\u1ea7n ph\u1ea3i d\u00f9ng h\u1ea1n ch\u1ebf cycloserin, ch\u1ec9 d\u00e0nh cycloserin \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb nh\u1eefng ng\u01b0\u1eddi b\u1ec7nh \u0111\u00e3 m\u1eafc lao kh\u00e1ng thu\u1ed1c.<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>Thu\u1ed1c c\u00f3 c\u1ea5u tr\u00fac gi\u1ed1ng acid amin d-alanin, v\u00ec th\u1ebf cycloserin \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p v\u1ecf t\u1ebf b\u00e0o c\u1ee7a c\u00e1c vi khu\u1ea5n nh\u1ea1y c\u1ea3m b\u1eb1ng c\u00e1ch c\u1ea1nh tranh v\u1edbi d-alanin \u0111\u1ebf s\u00e1p nh\u1eadp v\u00e0o v\u1ecf t\u1ebf b\u00e0o vi khu\u1ea5n. Cycloserin c\u00f3 th\u1ebf k\u00ecm khu\u1ea5n ho\u1eb7c di\u1ec7t khu\u1ea5n tu\u1ef3 theo n\u1ed3ng \u0111\u1ed9 thu\u1ed1c t\u1ea1i v\u1ecb tr\u00ed t\u1ed5n th\u01b0\u01a1ng v\u00e0 t\u00ednh nh\u1ea1y c\u1ea3m c\u1ee7a vi khu\u1ea5n g\u00e2y b\u1ec7nh. <em>In vitro,<\/em> t\u00ednh kh\u00e1ng khu\u1ea5n c\u1ee7a cycloserin c\u00f3 th\u1ebf b\u1ecb d-alanin \u1ee9c ch\u1ebf.<\/p>\n<p><a href=\"https:\/\/www.youtube.com\/watch?v=0TIIfoiJFwA\"><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/a><\/p>\n<p><strong>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/strong><\/p>\n<p><em>H\u1ea5p thu:<\/em> Sau khi u\u1ed1ng, 70% \u0111\u1ebfn 90% cycloserin \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh ch\u00f3ng. N\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong m\u00e1u \u0111\u1ea1t \u0111\u01b0\u1ee3c kho\u1ea3ng 10 microgam\/ml sau 3 &#8211; 4 gi\u1edd khi u\u1ed1ng li\u1ec1u 250 mg v\u00e0 c\u00f3 n\u1ed3ng \u0111\u1ed9 t\u1eeb 20 &#8211; 30 microgam\/ml khi u\u1ed1ng l\u1eb7p l\u1ea1i li\u1ec1u c\u00e1ch nhau 12 gi\u1edd. C\u00f3 th\u1ebf c\u00f3 m\u1ed9t l\u01b0\u1ee3ng thu\u1ed1c t\u00edch lu\u1ef9 \u1edf ng\u01b0\u1eddi b\u1ec7nh c\u00f3 ch\u1ee9c n\u0103ng th\u1eadn b\u00ecnh th\u01b0\u1eddng trong v\u00f2ng 3 ng\u00e0y \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb b\u1eb1ng cycloserin.<\/p>\n<p><em>Ph\u00e2n b\u1ed1:<\/em> Cycloserin \u0111\u01b0\u1ee3c ph\u00e2n b\u1ed1 r\u1ed9ng r\u00e3i v\u00e0o c\u00e1c m\u00f4 v\u00e0 d\u1ecbch trong c\u01a1 th\u1ebf g\u1ed3m c\u00f3 ph\u1ed5i, c\u1ed5 tr\u01b0\u1edbng, d\u1ecbch m\u00e0ng ph\u1ed5i, d\u1ecbch m\u00e0ng ho\u1ea1t d\u1ecbch v\u1edbi n\u1ed3ng \u0111\u1ed9 x\u1ea5p x\u1ec9 b\u1eb1ng n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong huy\u1ebft thanh. Cycloserin c\u0169ng ph\u00e2n b\u1ed1 v\u00e0o m\u1eadt, \u0111\u1eddm v\u00e0 m\u00f4 b\u1ea1ch huy\u1ebft. N\u1ed3ng \u0111\u1ed9 cycloserin trong d\u1ecbch n\u00e3o tu\u1ef7 b\u1eb1ng 50 &#8211; 80% n\u1ed3ng \u0111\u1ed9 thu\u1ed1c \u0111\u1ed3ng th\u1eddi trong huy\u1ebft t\u01b0\u01a1ng \u1edf ng\u01b0\u1eddi b\u1ec7nh c\u00f3 m\u00e0ng n\u00e3o kh\u00f4ng vi\u00eam v\u00e0 b\u1eb1ng 80 &#8211; 100% n\u1ed3ng \u0111\u1ed9 thu\u1ed1c \u0111\u1ed3ng th\u1eddi trong huy\u1ebft t\u01b0\u01a1ng \u1edf ng\u01b0\u1eddi b\u1ec7nh c\u00f3 m\u00e0ng n\u00e3o b\u1ecb vi\u00eam. Cycloserin kh\u00f4ng g\u1eafn v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng. Cycloserin d\u1ec5 d\u00e0ng qua nhau thai v\u00e0 ph\u00e2n b\u1ed1 v\u00e0o n\u01b0\u1edbc \u1ed1i. Cycloserin ph\u00e2n b\u1ed1 v\u00e0o s\u1eefa m\u1eb9.<\/p>\n<p><em>\u0110\u00e0o th\u1ea3i:<\/em> N\u1eeda \u0111\u1eddi c\u1ee7a cycloserin trong huy\u1ebft t\u01b0\u01a1ng x\u1ea5p x\u1ec9 10 gi\u1edd \u1edf ng\u01b0\u1eddi b\u1ec7nh c\u00f3 ch\u1ee9c n\u0103ng th\u1eadn b\u00ecnh th\u01b0\u1eddng. N\u1ed3ng \u0111\u1ed9 cycloserin trong huy\u1ebft t\u01b0\u01a1ng cao h\u01a1n v\u00e0 n\u1eeda \u0111\u1eddi k\u00e9o d\u00e0i h\u01a1n \u1edf ng\u01b0\u1eddi b\u1ec7nh c\u00f3 ch\u1ee9c n\u0103ng th\u1eadn b\u1ecb t\u1ed5n h\u1ea1i.<\/p>\n<p>\u1eda ng\u01b0\u1eddi b\u1ec7nh c\u00f3 ch\u1ee9c n\u0103ng th\u1eadn b\u00ecnh th\u01b0\u1eddng, 60 &#8211; 70% m\u1ed9t li\u1ec1u u\u1ed1ng cycloserin \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i kh\u00f4ng thay \u0111\u1ed5i qua l\u1ecdc c\u1ea7u th\u1eadn v\u00e0o n\u01b0\u1edbc ti\u1ec3u trong 24 gi\u1edd. T\u1ed1c \u0111\u1ed9 \u0111\u00e0o th\u1ea3i t\u1ed1i \u0111a trong v\u00f2ng 2 &#8211; 6 gi\u1edd \u0111\u1ea7u; kho\u1ea3ng 50% li\u1ec1u \u0111\u00e0o th\u1ea3i trong v\u00f2ng 12 gi\u1edd. M\u1ed9t l\u01b0\u1ee3ng nh\u1ecf cycloserin c\u0169ng \u0111ao th\u1ea3i v\u00e0o ph\u00e2n. Ph\u1ea7n c\u00f2n l\u1ea1i c\u1ee7a li\u1ec1u b\u1ecb chuy\u1ec3n ho\u00e1 nh\u01b0ng kh\u00f4ng x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c ch\u1ea5t chuy\u1ec3n ho\u00e1. Cycloserin c\u00f3 th\u1ec3 b\u1ecb t\u00edch l\u0169y \u0111\u1ebfn n\u1ed3ng \u0111\u1ed9 \u0111\u1ed9c \u1edf ng\u01b0\u1eddi b\u1ec7nh suy th\u1eadn; c\u00f3 th\u1ec3 lo\u1ea1i thu\u1ed1c ra kh\u1ecfi c\u01a1 th\u1ec3 b\u1eb1ng th\u1ea5m ph\u00e2n m\u00e1u.<\/p>\n<p><strong>5.3 Gi\u1ea3i th\u00edch: <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong>5.4 Thay th\u1ebf thu\u1ed1c : <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/strong><\/p>\n<p><strong>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/strong><\/p>\n<p>Talc, Erythrosin E127, Carmoisine E122, Yellow FCF E110, Titanium Dioxide E171, Black Iron Oxide E172, Gelatin<\/p>\n<p><strong>6.2. T\u01b0\u01a1ng k\u1ef5 :<\/strong><\/p>\n<p>Kh\u00f4ng \u00e1p d\u1ee5ng.<\/p>\n<p><strong>6.3. B\u1ea3o qu\u1ea3n: <\/strong><\/p>\n<p>B\u1ea3o qu\u1ea3n nang cycloserin trong bao b\u00ec k\u00edn \u1edf nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 40 <sup>o<\/sup>C, t\u1ed1t nh\u1ea5t \u1edf 15 &#8211; 30 <sup>o<\/sup>C. Cycloserin b\u1ec1n v\u1eefng trong m\u00f4i tr\u01b0\u1eddng ki\u1ec1m, nh\u01b0ng b\u1ecb ph\u00e2n h\u1ee7y nhanh trong m\u00f4i tr\u01b0\u1eddng trung t\u00ednh ho\u1eb7c acid.<\/p>\n<p><strong>6.4. Th\u00f4ng tin kh\u00e1c :<\/strong><\/p>\n<p>Kh\u00f4ng c\u00f3.<\/p>\n<p><strong>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/strong><\/p>\n<p>D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n<p>Ho\u1eb7c HDSD Thu\u1ed1c.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Cycloserine Ph\u00e2n lo\u1ea1i: Thu\u1ed1c kh\u00e1ng sinh d\u1eabn xu\u1ea5t Streptomyces Nh\u00f3m ph\u00e1p l\u00fd: Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine) M\u00e3 ATC (Anatomical Therapeutic Chemical): J04AB01. Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c: Bi\u1ec7t d\u01b0\u1ee3c: Pulcyclo H\u00e3ng s\u1ea3n xu\u1ea5t : C\u00f4ng ty c\u1ed5 ph\u1ea7n d\u01b0\u1ee3c [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":18945,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[643],"class_list":["post-18944","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-cycloserine"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/18944","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=18944"}],"version-history":[{"count":4,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/18944\/revisions"}],"predecessor-version":[{"id":50059,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/18944\/revisions\/50059"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/18945"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=18944"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=18944"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=18944"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}