{"id":18412,"date":"2020-05-13T14:20:56","date_gmt":"2020-05-13T07:20:56","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=18412"},"modified":"2025-01-08T20:58:46","modified_gmt":"2025-01-08T13:58:46","slug":"ceftazidime-sitacef","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/ceftazidime-sitacef\/","title":{"rendered":"Ceftazidime &#8211; Sitacef"},"content":{"rendered":"<p><strong>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: <\/strong><\/p>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <a href=\"https:\/\/pharmog.com\/wp\/ceftazidime\/\">Ceftazidime<\/a><\/strong><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u1ed1c Kh\u00e1ng sinh nh\u00f3m cephalosporin th\u1ebf h\u1ec7 3.<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): J01DD02.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em> <a href=\"https:\/\/pharmog.com\/wp\/ceftazidime-fortum\/\">FORTUM<\/a><\/strong><\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c:<\/em><\/strong> Sitacef<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: Laboratorio Internacional Argentino S.A<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng: <\/strong><\/p>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>L\u1ecd 1 g, b\u1ed9t v\u00f4 khu\u1ea5n \u0111\u1ec3 pha ti\u00eam ho\u1eb7c ti\u00eam truy\u1ec1n.<\/p>\n<p>H\u00e0m l\u01b0\u1ee3ng v\u00e0 li\u1ec1u l\u01b0\u1ee3ng bi\u1ec3u th\u1ecb theo d\u1ea1ng ceftazidim khan: 1 g ceftazidim khan t\u01b0\u01a1ng \u1ee9ng v\u1edbi 1,16 g ceftazidim pentahydrat.<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>SITACEF 1g<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i l\u1ecd thu\u1ed1c b\u1ed9t pha ti\u00eam c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Ceftazidime Natri<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>1000 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"593\" height=\"341\" class=\"wp-image-18413\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-297.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-297.png 593w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-297-300x173.png 300w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-297-278x160.png 278w\" sizes=\"auto, (max-width: 593px) 100vw, 593px\" \/><\/p>\n<p><strong>3. Video by Pharmog:<\/strong><\/p>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe loading=\"lazy\" title=\"[Pharmog SS1 - T\u1eadp 08] - D\u01b0\u1ee3c l\u00fd c\u00e1c thu\u1ed1c kh\u00e1ng sinh\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/0TIIfoiJFwA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<p><strong>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng: <\/strong><\/p>\n<p><strong>4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>Sitacef \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh nhi\u1ec5m tr\u00f9ng d\u01b0\u1edbi \u0111\u00e2y \u1edf ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em bao g\u1ed3m c\u1ea3 tr\u1ebb s\u01a1 sinh (t\u1eeb khi sinh ra):<\/p>\n<p>Vi\u00eam ph\u1ed5i b\u1ec7nh vi\u1ec7n.<\/p>\n<p>Nhi\u1ec5m tr\u00f9ng ph\u1ebf qu\u1ea3n-ph\u1ed5i \u1edf b\u1ec7nh nh\u00e2n x\u01a1 nang.<\/p>\n<p>Vi\u00eam m\u00e0ng n\u00e3o do vi khu\u1ea9n.<\/p>\n<p>Vi\u00eam tai gi\u1eefa m\u1ea1n t\u00ednh.<\/p>\n<p>Vi\u00eam tai ngo\u00e0i \u00e1c t\u00ednh.<\/p>\n<p>Nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u c\u00f3 bi\u1ebfn ch\u1ee9ng.<\/p>\n<p>Nhi\u1ec5m tr\u00f9ng da v\u00e0 m\u00f4 m\u1ec1m c\u00f3 bi\u1ebfn ch\u1ee9ng.<\/p>\n<p>Nhi\u1ec5m tr\u00f9ng trong \u1ed5 b\u1ee5ng c\u00f3 bi\u1ebfn ch\u1ee9ng.<\/p>\n<p>Nhi\u1ec5m tr\u00f9ng x\u01b0\u01a1ng v\u00e0 kh\u1edbp.<\/p>\n<p>Nhi\u1ec5m tr\u00f9ng ph\u00fac m\u1ea1c k\u1ebft h\u1ee3p v\u1edbi th\u1ea9m ph\u00e2n ph\u00fac m\u1ea1c \u1edf b\u1ec7nh nh\u00e2n th\u1ea9m ph\u00e2n ph\u00fac m\u1ea1c li\u00ean t\u1ee5c.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb \u1edf b\u1ec7nh nh\u00e2n nhi\u1ec5m tr\u00f9ng m\u00e1u x\u1ea3y ra k\u1ebft h\u1ee3p v\u1edbi ho\u1eb7c b\u1ecb nghi ng\u1edd li\u00ean quan \u0111\u1ebfn b\u1ea5t k\u1ef3 c\u00e1c nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1ee3c li\u1ec7t k\u00ea nh\u01b0 tr\u00ean.<\/p>\n<p>Ceftazidim \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u1edf b\u1ec7nh nh\u00e2n b\u1ecb s\u1ed1t k\u00e8m gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh b\u1ecb nghi ng\u1edd do nhi\u1ec5m khu\u1ea9n.<\/p>\n<p>Ceftazidim c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong d\u1ef1 ph\u00f2ng nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u \u1edf b\u1ec7nh nh\u00e2n ph\u1eabu thu\u1eadt c\u1eaft tuy\u1ebfn ti\u1ec1n li\u1ec7t qua ni\u1ec7u \u0111\u1ea1o (TURP).<\/p>\n<p>Vi\u1ec7c l\u1ef1a ch\u1ecdn kh\u00e1ng sinh ceftazidim n\u00ean c\u00e2n t\u00ednh t\u1edbi ph\u1ed5 kh\u00e1ng khu\u1ea9n c\u1ee7a kh\u00e1ng sinh m\u00e0 th\u01b0\u1eddng ch\u1ee7 y\u1ebfu gi\u00f3i h\u1ea1n v\u1edbi c\u00e1c vi khu\u1ea9n Gram (-) k\u1ecb kh\u00ed.<\/p>\n<p>Ceftazidim n\u00ean \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c kh\u00e1ng sinh kh\u00e1c b\u1ea5t k\u1ef3 khi n\u00e0o m\u00e0 ph\u1ea1m vi ho\u1ea1t \u0111\u1ed9ng c\u1ee7a vi khu\u1ea9n kh\u00f4ng \u1edf trong ph\u1ed5 ho\u1ea1t \u0111\u1ed9ng c\u1ee7a kh\u00e1ng sinh.<\/p>\n<p>C\u00e2n nh\u1eafc th\u1ef1c h\u00e0nh theo c\u00e1c h\u01b0\u1edbng d\u1eabn ch\u00ednh th\u1ee9c \u0111\u1ec3 s\u1eed d\u1ee5ng kh\u00e1ng sinh \u0111\u00fang<\/p>\n<p><strong>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/strong><\/p>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p>d\u00f9ng ti\u00eam b\u1eafp s\u00e2u, ti\u00eam t\u0129nh m\u1ea1ch ch\u1eadm trong 3 &#8211; 5 ph\u00fat, ho\u1eb7c ti\u00eam truy\u1ec1n t\u0129nh m\u1ea1ch.<\/p>\n<p>Ti\u00eam b\u1eafp: Ho\u00e0 tan thu\u1ed1c b\u1eb1ng 4ml n\u01b0\u1edbc c\u1ea5t pha ti\u00eam (250 mg\/ml). Dung d\u1ecbch sau khi pha n\u00ean d\u00f9ng ngay ho\u1eb7c trong v\u00f2ng 18 gi\u1edd \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng ho\u1eb7c 7 ng\u00e0y khi \u0111\u1ec3 t\u1ee7 l\u1ea1nh.<\/p>\n<p>Ti\u00eam t\u0129nh m\u1ea1ch, ti\u00eam truy\u1ec1n t\u0129nh m\u1ea1ch: Ho\u00e0 tan thu\u1ed1c t\u01b0\u01a1ng \u1ee9ng v\u1edbi 10ml v\u00e0 100ml n\u01b0\u1edbc c\u1ea5t pha ti\u00eam, dung d\u1ecbch natri clorid 0,9%, ho\u1eb7c dextrose 5%. Dung d\u1ecbch sau khi pha \u0111\u01b0\u1ee3c d\u00f9ng ngay ho\u1eb7c trong v\u00f2ng 24 gi\u1edd \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng ho\u1eb7c 7 ng\u00e0y khi \u0111\u1ec3 t\u1ee7 l\u1ea1nh.<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p><em>Ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em \u2265 40 kg:<\/em><\/p>\n<table>\n<tbody>\n<tr>\n<td><strong><em>Ph\u01b0\u01a1ng ph\u00e1p s\u1eed d\u1ee5ng gi\u00e1n \u0111o\u1ea1n<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td><em>Lo\u1ea1i nhi\u1ec5m tr\u00f9ng<\/em><\/td>\n<td><em>Li\u1ec1u \u0111i\u1ec1u tr\u1ecb<\/em><\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m tr\u00f9ng ph\u1ebf qu\u1ea3n-ph\u1ed5i \u1edf b\u1ec7nh nh\u00e2n x\u01a1 nang<\/td>\n<td>100 \u2013 150 mg\/kg\/ng\u00e0y m\u1ed7i 8 h, t\u1ed1i \u0111a 9 h m\u1ed7i ng\u00e0y (1)<\/td>\n<\/tr>\n<tr>\n<td>Gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh do s\u1ed1t<\/td>\n<td rowspan=\"4\">2 g m\u1ed7i 8 h<\/td>\n<\/tr>\n<tr>\n<td>Vi\u00eam ph\u1ed5i b\u1ec7nh vi\u1ec7n<\/td>\n<\/tr>\n<tr>\n<td>Vi\u00eam m\u00e0ng n\u00e3o do vi khu\u1ea9n<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m khu\u1ea9n huy\u1ebft *<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m tr\u00f9ng x\u01b0\u01a1ng v\u00e0 kh\u1edbp<\/td>\n<td rowspan=\"4\">1 \u2013 2 g m\u1ed7i 8 h<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m tr\u00f9ng da v\u00e0 m\u00f4 m\u1ec1m c\u00f3 bi\u1ebfn ch\u1ee9ng<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m tr\u00f9ng trong \u1ed5 b\u1ee5ng c\u00f3 bi\u1ebfn ch\u1ee9ng<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m tr\u00f9ng ph\u00fac m\u1ea1c k\u1ebft h\u1ee3p v\u1edbi th\u1ea9m ph\u00e2n ph\u00fac m\u1ea1c \u1edf b\u1ec7nh nh\u00e2n th\u1ea9m ph\u00e2n ph\u00fac m\u1ea1c li\u00ean t\u1ee5c<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\">Nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u c\u00f3 bi\u1ebfn ch\u1ee9ng<\/td>\n<td rowspan=\"2\">1 \u2013 2 g m\u1ed7i 8 h ho\u1eb7c 12 h<\/td>\n<\/tr>\n<tr>\n<td>D\u1ef1 ph\u00f2ng trong ph\u1eabu thu\u1eadt c\u1eaft tuy\u1ebfn ti\u1ec1n li\u1ec7t qua ni\u1ec7u \u0111\u1ea1o (TURP)<\/td>\n<td>1 g l\u00fac g\u00e2y m\u00ea v\u00e0 li\u1ec1u th\u1ee9 2 l\u00fac b\u1ecf \u1ed1ng th\u00f4ng<\/td>\n<\/tr>\n<tr>\n<td>Vi\u00eam tai gi\u1eefa m\u00e3n t\u00ednh.<\/td>\n<td rowspan=\"2\">1 \u2013 2 g m\u1ed7i 8 h<\/td>\n<\/tr>\n<tr>\n<td>Vi\u00eam tai ngo\u00e0i \u00e1c t\u00ednh.<\/td>\n<\/tr>\n<tr>\n<td><strong><em>Ph\u01b0\u01a1ng ph\u00e1p truy\u1ec1n li\u00ean t\u1ee5c<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td><em>Lo\u1ea1i nhi\u1ec5m tr\u00f9ng<\/em><\/td>\n<td><em>Li\u1ec1u d\u00f9ng<\/em><\/td>\n<\/tr>\n<tr>\n<td>Gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh do s\u1ed1t<\/td>\n<td rowspan=\"9\">Li\u1ec1u t\u1ea3i 2 g, sau \u0111\u00f3 truy\u1ec1n li\u00ean t\u1ee5c 4 \u2013 6 g m\u1ed7i 24 h (1)<\/td>\n<\/tr>\n<tr>\n<td>Vi\u00eam ph\u1ed5i b\u1ec7nh vi\u1ec7n<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m tr\u00f9ng ph\u1ebf qu\u1ea3n-ph\u1ed5i \u1edf b\u1ec7nh nh\u00e2n x\u01a1 nang<\/td>\n<\/tr>\n<tr>\n<td>Vi\u00eam m\u00e0ng n\u00e3o do vi khu\u1ea9n<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m khu\u1ea9n huy\u1ebft *<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m tr\u00f9ng x\u01b0\u01a1ng v\u00e0 kh\u1edbp<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m tr\u00f9ng da v\u00e0 m\u00f4 m\u1ec1m c\u00f3 bi\u1ebfn ch\u1ee9ng<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m tr\u00f9ng trong \u1ed5 b\u1ee5ng c\u00f3 bi\u1ebfn ch\u1ee9ng<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m tr\u00f9ng ph\u00fac m\u1ea1c k\u1ebft h\u1ee3p v\u1edbi th\u1ea9m ph\u00e2n ph\u00fac m\u1ea1c \u1edf b\u1ec7nh nh\u00e2n th\u1ea9m ph\u00e2n ph\u00fac m\u1ea1c li\u00ean t\u1ee5c<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>(1): \u1ede ng\u01b0\u1eddi l\u1edbn v\u1edbi ch\u1ee9c n\u0103ng th\u1eadn b\u00ecnh th\u01b0\u1eddng, li\u1ec1u 9 g\/ng\u00e0y \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng m\u00e0 kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng ph\u1ee5.<\/p>\n<p>*: Khi k\u1ebft h\u1ee3p v\u1edbi ho\u1eb7c nghi ng\u1edd li\u00ean quan \u0111\u1ebfn c\u00e1c nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1ee3c li\u1ec7t k\u00ea \u1edf m\u1ee5c \u201cCh\u1ec9 \u0111\u1ecbnh\u201d<\/p>\n<p><em>Tr\u1ebb em &lt; 40kg:<\/em><\/p>\n<table>\n<tbody>\n<tr>\n<td><strong>2.1 V\u1edbi tr\u1ebb s\u01a1 sinh v\u00e0 tr\u1ebb m\u1edbi bi\u1ebft \u0111i &gt; 2 th\u00e1ng v\u00e0 tr\u1ebb em &lt; 40 kg.<\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td><em>Lo\u1ea1i nhi\u1ec5m tr\u00f9ng<\/em><\/td>\n<td><em>Li\u1ec1u d\u00f9ng<\/em><\/td>\n<\/tr>\n<tr>\n<td><strong><em>Ph\u01b0\u01a1ng ph\u00e1p s\u1eed d\u1ee5ng gi\u00e1n \u0111o\u1ea1n<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u c\u00f3 bi\u1ebfn ch\u1ee9ng<\/td>\n<td rowspan=\"3\">100 \u2013 150 mg\/kg\/ng\u00e0y, chia l\u00e0m 3 l\u1ea7n, t\u1ed1i \u0111a 6 g\/ng\u00e0y.<\/td>\n<\/tr>\n<tr>\n<td>Vi\u00eam tai gi\u1eefa m\u00e3n t\u00ednh.<\/td>\n<\/tr>\n<tr>\n<td>Vi\u00eam tai ngo\u00e0i \u00e1c t\u00ednh.<\/td>\n<\/tr>\n<tr>\n<td>Tr\u1ebb em b\u1ecb gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh<\/td>\n<td rowspan=\"4\">150 mg\/kg\/ng\u00e0y, chia l\u00e0m 3 l\u1ea7n, t\u1ed1i \u0111a 6 g\/ng\u00e0y.<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m tr\u00f9ng ph\u1ebf qu\u1ea3n-ph\u1ed5i \u1edf b\u1ec7nh nh\u00e2n x\u01a1 nang<\/td>\n<\/tr>\n<tr>\n<td>Vi\u00eam m\u00e0ng n\u00e3o do vi khu\u1ea9n<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m khu\u1ea9n huy\u1ebft *<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m tr\u00f9ng x\u01b0\u01a1ng v\u00e0 kh\u1edbp<\/td>\n<td rowspan=\"4\">100 \u2013 150 mg\/kg\/ng\u00e0y, chia l\u00e0m 3 l\u1ea7n, t\u1ed1i \u0111a 6 g\/ng\u00e0y.<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m tr\u00f9ng da v\u00e0 m\u00f4 m\u1ec1m c\u00f3 bi\u1ebfn ch\u1ee9ng<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m tr\u00f9ng trong \u1ed5 b\u1ee5ng c\u00f3 bi\u1ebfn ch\u1ee9ng<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m tr\u00f9ng ph\u00fac m\u1ea1c k\u1ebft h\u1ee3p v\u1edbi th\u1ea9m ph\u00e2n ph\u00fac m\u1ea1c \u1edf b\u1ec7nh nh\u00e2n th\u1ea9m ph\u00e2n ph\u00fac m\u1ea1c li\u00ean t\u1ee5c<\/td>\n<\/tr>\n<tr>\n<td><strong><em>Ph\u01b0\u01a1ng ph\u00e1p truy\u1ec1n li\u00ean t\u1ee5c<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh do s\u1ed1t<\/td>\n<td rowspan=\"9\">Li\u1ec1u t\u1ea3i 60 \u2013 100 mg\/kg, sau \u0111\u00f3 truy\u1ec1n li\u00ean t\u1ee5c<br \/>\n100 \u2013 200 mg\/kg\/ng\u00e0y, t\u1ed1i \u0111a 6 g\/ng\u00e0y<\/td>\n<\/tr>\n<tr>\n<td>Vi\u00eam ph\u1ed5i b\u1ec7nh vi\u1ec7n<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m tr\u00f9ng ph\u1ebf qu\u1ea3n-ph\u1ed5i \u1edf b\u1ec7nh nh\u00e2n x\u01a1 nang<\/td>\n<\/tr>\n<tr>\n<td>Vi\u00eam m\u00e0ng n\u00e3o do vi khu\u1ea9n<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m khu\u1ea9n huy\u1ebft *<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m tr\u00f9ng x\u01b0\u01a1ng v\u00e0 kh\u1edbp<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m tr\u00f9ng da v\u00e0 m\u00f4 m\u1ec1m c\u00f3 bi\u1ebfn ch\u1ee9ng<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m tr\u00f9ng trong \u1ed5 b\u1ee5ng c\u00f3 bi\u1ebfn ch\u1ee9ng<\/td>\n<\/tr>\n<tr>\n<td>Nhi\u1ec5m tr\u00f9ng ph\u00fac m\u1ea1c k\u1ebft h\u1ee3p v\u1edbi th\u1ea9m ph\u00e2n ph\u00fac m\u1ea1c \u1edf b\u1ec7nh nh\u00e2n th\u1ea9m ph\u00e2n ph\u00fac m\u1ea1c li\u00ean t\u1ee5c<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><em>Tr\u1ebb s\u01a1 sinh v\u00e0 tr\u1ebb em &lt; 2 th\u00e1ng <\/em><\/p>\n<p>D\u00f9ng gi\u00e1n \u0111o\u1ea1n:<\/p>\n<p>H\u1ea7u h\u1ebft c\u00e1c nhi\u1ec5m tr\u00f9ng : 25 &#8211; 60 mg\/kg\/ng\u00e0y chia l\u00e0m 2 l\u1ea7n(1)<\/p>\n<p>(1): Tr\u1ebb s\u01a1 sinh v\u00e0 tr\u1ebb &lt; 2 th\u00e1ng, th\u1eddi gian b\u00e1n th\u1ea3i trong huy\u1ebft thanh c\u00f3 th\u1ec3 cao h\u01a1n 3 \u2013 4 l\u1ea7n so v\u1edbi ng\u01b0\u1eddi l\u1edbn.<\/p>\n<p>*: Khi k\u1ebft h\u1ee3p v\u1edbi ho\u1eb7c nghi ng\u1edd li\u00ean quan \u0111\u1ebfn c\u00e1c nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1ee3c li\u1ec7t k\u00ea \u1edf m\u1ee5c \u201cCh\u1ec9 \u0111\u1ecbnh\u201d.<\/p>\n<p>\u0110\u1ed1i t\u01b0\u1ee3ng tr\u1ebb em : Hi\u1ec7u qu\u1ea3 v\u00e0 an to\u00e0n c\u1ee7a ceftazidim khi truy\u1ec1n li\u00ean t\u1ee5c \u1ecf&#8217; tr\u1ebb s\u01a1 sinh v\u00e0 tr\u1ebb em &lt; 2 th\u00e1ng v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp.<\/p>\n<p><em>Ng\u01b0\u1eddi cao tu\u1ed5i<\/em>: theo quan \u0111i\u1ec3m v\u1ec1 tu\u1ed5i t\u00e1c li\u00ean quan \u0111\u1ebfn vi\u1ec7c gi\u1ea3m \u0111\u1ed9 thanh th\u1ea3i c\u1ee7a ceftazidim \u1edf ng\u01b0\u1eddi cao tu\u1ed5i, li\u1ec1u d\u00f9ng kh\u00f4ng n\u00ean v\u01b0\u1ee3t qu\u00e1 3 g \u1edf b\u1ec7nh nh\u00e2n tr\u00ean 80 tu\u1ed5i.<\/p>\n<p><em>B\u1ec7nh nh\u00e2n suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn <\/em>: ceftazidim \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i qua th\u1eadn d\u01b0\u1edbi d\u1ea1ng kh\u00f4ng \u0111\u1ed5i. V\u00ec v\u1eady, c\u1ea7n ph\u1ea3i gi\u1ea3m li\u1ec1u \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn.<\/p>\n<p>Li\u1ec1u t\u1ea3i \u0111\u1ea7u ti\u00ean l\u00e0 1 g. Li\u1ec1u duy tr\u00ec n\u00ean d\u1ef1a tr\u00ean \u0111\u1ed9 thanh th\u1ea3i creatinin<\/p>\n<p><em>Li\u1ec1u duy tr\u00ec \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn \u2013 ph\u01b0\u01a1ng ph\u00e1p truy\u1ec1n gi\u00e1n \u0111o\u1ea1n:<\/em><\/p>\n<p><em>V\u1edbi ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em \u2265 40 kg<\/em><\/p>\n<table>\n<tbody>\n<tr>\n<td><strong>\u0110\u1ed9 thanh th\u1ea3i creatinin (ml\/ph\u00fat)<\/strong><\/td>\n<td><strong>Creatinin huy\u1ebft t\u01b0\u01a1ng (\u00b5mol\/l)<\/strong><\/td>\n<td><strong>Li\u1ec1u duy tr\u00ec<\/strong><\/td>\n<\/tr>\n<tr>\n<td>50 \u2013 31<\/td>\n<td>150 \u2013 200<\/td>\n<td>1 g c\u00e1ch 12 gi\u1edd 1 l\u1ea7n<\/td>\n<\/tr>\n<tr>\n<td>30 \u2013 16<\/td>\n<td>200 \u2013 350<\/td>\n<td>1 g c\u00e1ch 24 gi\u1edd 1 l\u1ea7n<\/td>\n<\/tr>\n<tr>\n<td>15 \u2013 6<\/td>\n<td>350 \u2013 500<\/td>\n<td>0,5 g c\u00e1ch 24 gi\u1edd 1 l\u1ea7n<\/td>\n<\/tr>\n<tr>\n<td>&lt; 5<\/td>\n<td>&gt; 500<\/td>\n<td>0,5 g c\u00e1ch 48 gi\u1edd 1 l\u1ea7n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u1ede b\u1ec7nh nh\u00e2n b\u1ecb nhi\u1ec5m tr\u00f9ng n\u1eb7ng: n\u00ean t\u0103ng 50% \u0111\u01a1n v\u1ecb li\u1ec1u ho\u1eb7c t\u0103ng t\u1ea7n su\u1ea5t s\u1eed d\u1ee5ng. Tr\u1ebb em v\u1edbi \u0111\u1ed9 thanh th\u1ea3i creatinin n\u00ean \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh theo di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t c\u01a1 th\u1ec3 ho\u1eb7c tr\u1ecdng l\u01b0\u1ee3ng n\u1ea1c c\u01a1 th\u1ec3.<\/p>\n<p><em>Tr\u1ebb em &lt; 40 kg.<\/em><\/p>\n<table>\n<tbody>\n<tr>\n<td><strong>\u0110\u1ed9 thanh th\u1ea3i creatinin (ml\/ph\u00fat)**<\/strong><\/td>\n<td><strong>Creatinin huy\u1ebft t\u01b0\u01a1ng *\u00b5mol\/l<\/strong><\/td>\n<td><strong>Li\u1ec1u d\u00f9ng<\/strong><\/td>\n<\/tr>\n<tr>\n<td>50 \u2013 31<\/td>\n<td>150 \u2013 200<\/td>\n<td>25 mg\/kg c\u00e1ch 12 gi\u1edd 1 l\u1ea7n<\/td>\n<\/tr>\n<tr>\n<td>30 \u2013 16<\/td>\n<td>200 \u2013 350<\/td>\n<td>25 mg\/kg c\u00e1ch 24 gi\u1edd 1 l\u1ea7n<\/td>\n<\/tr>\n<tr>\n<td>15 \u2013 6<\/td>\n<td>350 \u2013 500<\/td>\n<td>12,5 mg\/kg c\u00e1ch 24 gi\u1edd 1 l\u1ea7n<\/td>\n<\/tr>\n<tr>\n<td>&lt; 5<\/td>\n<td>&gt; 500<\/td>\n<td>12,5 mg\/kg c\u00e1ch 48 gi\u1edd 1 l\u1ea7n<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\">* C\u00e1c gi\u00e1 tr\u1ecb creatinin huy\u1ebft thanh l\u00e0 c\u00e1c gi\u00e1 tr\u1ecb h\u01b0\u1edbng d\u1eabn, c\u00f3 th\u1ec3 kh\u00f4ng ch\u1ec9 ra<br \/>\nch\u00ednh x\u00e1c m\u1ee9c \u0111\u1ed9 gi\u1ea3m gi\u1ed1ng nhau \u0111\u1ed1i v\u1edbi t\u1ea5t c\u1ea3 c\u00e1c b\u1ec7nh nh\u00e2n b\u1ecb suy th\u1eadn.<br \/>\n** \u01af\u1edbc t\u00ednh d\u1ef1a tr\u00ean di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t c\u01a1 th\u1ec3 ho\u1eb7c \u0111\u01b0\u1ee3c \u0111o.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>C\u1ea7n ph\u1ea3i theo d\u00f5i l\u00e2m s\u00e0ng ch\u1eb7t ch\u1ebd v\u1ec1 \u0111\u1ed9 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3.<\/p>\n<p><em>Li\u1ec1u duy tr\u00ec \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o c\u1ee7a ceftazidim \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn \u2013 ph\u01b0\u01a1ng ph\u00e1p truy\u1ec1n li\u00ean t\u1ee5c:<\/em><\/p>\n<p><em>Ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em \u2265 40 kg:<\/em><\/p>\n<table>\n<tbody>\n<tr>\n<td><strong>\u0110\u1ed9 thanh th\u1ea3i creatinin (ml\/ph\u00fat)<\/strong><\/td>\n<td><strong>Creatinin huy\u1ebft t\u01b0\u01a1ng \u00b5mol\/l<\/strong><\/td>\n<td><strong>Li\u1ec1u d\u00f9ng<\/strong><\/td>\n<\/tr>\n<tr>\n<td>50 \u2013 31<\/td>\n<td>150 \u2013 200<\/td>\n<td>Li\u1ec1u t\u1ea3i 2 g, sau \u0111\u00f3 d\u00f9ng 1 \u2013 3 g\/24 h<\/td>\n<\/tr>\n<tr>\n<td>30 \u2013 16<\/td>\n<td>200 \u2013 350<\/td>\n<td>Li\u1ec1u t\u1ea3i 2 g, sau \u0111\u00f3 d\u00f9ng 1 g\/24h<\/td>\n<\/tr>\n<tr>\n<td>\u2264 15<\/td>\n<td>&gt; 350<\/td>\n<td>Ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>C\u1ea7n ph\u1ea3i theo d\u00f5i l\u00e2m s\u00e0ng ch\u1eb7t ch\u1ebd v\u1ec1 \u0111\u1ed9 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3.<\/p>\n<p><em>Tr\u1ebb em &lt; 40 kg:<\/em> \u0110\u1ed9 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 khi d\u00f9ng \u0111\u01b0\u1eddng truy\u1ec1n t\u0129nh m\u1ea1ch li\u00ean t\u1ee5c cho tr\u1ebb em b\u1ecb suy th\u1eadn &lt; 40 kg ch\u01b0a \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp. C\u1ea7n theo d\u00f5i l\u00e2m s\u00e0ng ch\u1eb7t ch\u1ebd v\u1ec1 \u0111\u1ed9 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3. N\u1ebfu d\u00f9ng \u0111\u01b0\u1eddng truy\u1ec1n t\u0129nh m\u1ea1ch li\u00ean t\u1ee5c cho tr\u1ebb em b\u1ecb suy th\u1eadn, \u0111\u1ed9 thanh th\u1ea3i creatinin n\u00ean \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh so v\u1edbi di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t c\u01a1 th\u1ec3 ho\u1eb7c tr\u1ecdng l\u01b0\u1ee3ng n\u1ea1c c\u01a1 th\u1ec3.<\/p>\n<p><em>Th\u1ea9m t\u00e1ch m\u00e1u:<\/em><\/p>\n<p>Th\u1eddi gian b\u00e1n th\u1ea3i trong qu\u00e1 tr\u00ecnh th\u1ea9m t\u00e1ch m\u00e1u kho\u1ea3ng 3 \u2013 5 h. Sau m\u1ed7i giai \u0111o\u1ea1n th\u1ea9m t\u00e1ch m\u00e1u, li\u1ec1u duy tr\u00ec c\u1ee7a ceftazidim n\u00ean \u0111\u01b0\u1ee3c l\u1eb7p l\u1ea1i theo b\u1ea3ng b\u00ean d\u01b0\u1edbi.<\/p>\n<p><em>Th\u1ea9m ph\u00e2n ph\u00fac m\u1ea1c:<\/em><\/p>\n<p>Ceftazidim c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong th\u1ea9m ph\u00e2n ph\u00fac m\u1ea1c v\u00e0 th\u1ea9m ph\u00e2n ph\u00fac m\u1ea1c li\u00ean t\u1ee5c ngo\u1ea1i tr\u00fa (CAPD).<\/p>\n<p>Ngo\u00e0i vi\u1ec7c s\u1eed d\u1ee5ng \u0111\u01b0\u1eddng truy\u1ec1n t\u0129nh m\u1ea1ch, ceftazidim c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c k\u1ebft h\u1ee3p v\u00e0o d\u1ecbch th\u1ea9m t\u00e1ch (th\u00f4ng th\u01b0\u1eddng 125 \u2013 250 mg trong 2 l\u00edt d\u1ecbch th\u1ea9m t\u00e1ch).<\/p>\n<p>\u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n b\u1ecb suy th\u1eadn \u0111ang \u0111\u01b0\u1ee3c th\u1ea9m t\u00e1ch m\u00e1u li\u00ean t\u1ee5c \u0111\u1ed9ng \u2013 t\u0129nh m\u1ea1ch ho\u1eb7c l\u1ecdc m\u00e1u qua m\u00e0ng l\u1ecdc high-flux trong c\u00e1c \u0111\u01a1n v\u1ecb \u0111i\u1ec1u tr\u1ecb chuy\u00ean s\u00e2u: 1 g m\u1ed7i ng\u00e0y, d\u00f9ng li\u1ec1u \u0111\u01a1n ho\u1eb7c d\u00f9ng nhi\u1ec1u l\u1ea7n. \u0110\u1ed1i v\u1edbi l\u1ecdc m\u00e1u qua m\u00e0ng l\u1ecdc low-flux, theo li\u1ec1u khuy\u1ebfn c\u00e1o d\u00f9ng \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn.<\/p>\n<p>\u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n \u0111ang l\u1ecdc m\u00e1u t\u0129nh m\u1ea1ch \u2013 t\u0129nh m\u1ea1ch v\u00e0 th\u1ea9m t\u00e1ch m\u00e1u t\u0129nh m\u1ea1ch \u2013 t\u0129nh m\u1ea1ch, theo li\u1ec1u khuy\u1ebfn c\u00e1o theo b\u00e0ng d\u01b0\u1edbi \u0111\u00e2y:<\/p>\n<p><em>B\u1ea3ng 1: H\u01b0\u1edbng d\u1eabn li\u1ec1u trong l\u1ecdc m\u00e1u li\u00ean t\u1ee5c t\u0129nh m\u1ea1ch \u2013 t\u0129nh m\u1ea1ch<\/em><\/p>\n<table>\n<tbody>\n<tr>\n<td><strong>\u0110\u1ed9 thanh th\u1ea3i creatinin (ml\/ph\u00fat)<\/strong><\/td>\n<td colspan=\"4\"><strong>Li\u1ec1u duy tr\u00ec (mg) t\u01b0\u01a1ng \u1ee9ng v\u1edbi t\u1ed1c \u0111\u1ed9 l\u1ecdc m\u00e1u (ml\/ph\u00fat) (li\u1ec1u \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng m\u1ed7i 12 h)<\/strong><\/td>\n<\/tr>\n<tr>\n<td>0<\/td>\n<td><strong>5<\/strong><\/td>\n<td><strong>16,7<\/strong><\/td>\n<td><strong>33,3<\/strong><\/td>\n<td><strong>50<\/strong><\/td>\n<\/tr>\n<tr>\n<td>5<\/td>\n<td>250<\/td>\n<td>250<\/td>\n<td>500<\/td>\n<td>500<\/td>\n<\/tr>\n<tr>\n<td>10<\/td>\n<td>250<\/td>\n<td>250<\/td>\n<td>500<\/td>\n<td>500<\/td>\n<\/tr>\n<tr>\n<td>15<\/td>\n<td>250<\/td>\n<td>500<\/td>\n<td>500<\/td>\n<td>750<\/td>\n<\/tr>\n<tr>\n<td>20<\/td>\n<td>250<\/td>\n<td>500<\/td>\n<td>500<\/td>\n<td>750<\/td>\n<\/tr>\n<tr>\n<td>20<\/td>\n<td>500<\/td>\n<td>500<\/td>\n<td>500<\/td>\n<td>750<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><em>B\u1ea3ng 2: H\u01b0\u1edbng d\u1eabn li\u1ec1u trong th\u1ea9m t\u00e1ch m\u00e1u li\u00ean t\u1ee5c t\u0129nh m\u1ea1ch \u2013 t\u0129nh m\u1ea1ch:<\/em><\/p>\n<table>\n<tbody>\n<tr>\n<td rowspan=\"4\"><strong>\u0110\u1ed9 thanh th\u1ea3i creatinin (ml\/ph\u00fat)<\/strong><\/td>\n<td colspan=\"6\"><strong>Li\u1ec1u duy tr\u00ec (mg) \u0111\u1ed1i v\u1edbi th\u1ea9m t\u00e1ch m\u00e1u theo t\u1ed1c \u0111\u1ed9 ch\u1ea3y t\u01b0\u01a1ng \u1ee9ng (li\u1ec1u \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng m\u1ed7i 12 h)<\/strong><\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\">1 L\/h<\/td>\n<td colspan=\"3\">2 L\/h<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\">T\u1ed1c \u0111\u1ed9 l\u1ecdc (L\/h)<\/td>\n<td colspan=\"3\">T\u1ed1c \u0111\u1ed9 l\u1ecdc (L\/h)<\/td>\n<\/tr>\n<tr>\n<td>0,5<\/td>\n<td>1<\/td>\n<td>2<\/td>\n<td>0,5<\/td>\n<td>1<\/td>\n<td>2<\/td>\n<\/tr>\n<tr>\n<td>0<\/td>\n<td>500<\/td>\n<td>500<\/td>\n<td>500<\/td>\n<td>500<\/td>\n<td>500<\/td>\n<td>750<\/td>\n<\/tr>\n<tr>\n<td>5<\/td>\n<td>500<\/td>\n<td>500<\/td>\n<td>750<\/td>\n<td>500<\/td>\n<td>500<\/td>\n<td>750<\/td>\n<\/tr>\n<tr>\n<td>10<\/td>\n<td>500<\/td>\n<td>500<\/td>\n<td>750<\/td>\n<td>500<\/td>\n<td>750<\/td>\n<td>1000<\/td>\n<\/tr>\n<tr>\n<td>15<\/td>\n<td>500<\/td>\n<td>750<\/td>\n<td>750<\/td>\n<td>750<\/td>\n<td>750<\/td>\n<td>1000<\/td>\n<\/tr>\n<tr>\n<td>20<\/td>\n<td>750<\/td>\n<td>750<\/td>\n<td>1000<\/td>\n<td>750<\/td>\n<td>750<\/td>\n<td>1000<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>Ng\u01b0\u00f2i m\u00e2n c\u1ea3m v\u1edbi ceftazidim, b\u1ea5t k\u1ef3 kh\u00e1ng sinh n\u00e0o nh\u00f3m penicilin v\u00e0 cephalosporin ho\u0103c t\u00e1 d\u01b0\u01a1c c\u1ee7a thu\u1ed1c.<\/p>\n<p>B\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed qu\u00e1 m\u1eabn n\u1eb7ng (nh\u01b0 ph\u1ea3n \u1ee9ng ph\u1ea3n v\u1ec7) v\u1edbi b\u1ea5t k\u1ef3 kh\u00e1ng sinh beta-lactam n\u00e0o (penicillin, monobactam v\u00e0 carbapenem)<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>4.4 Th\u1eadn tr\u1ecdng:<\/strong><\/p>\n<p><em>Qu\u00e1 m\u1eabn:<\/em><\/p>\n<p>Gi\u1ed1ng nh\u01b0 t\u1ea5t c\u1ea3 c\u00e1c thu\u1ed1c kh\u00e1ng khu\u1ea9n nh\u00f3m beta-lactam, ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn nghi\u00eam tr\u1ecdng ho\u1eb7c \u0111\u00f4i khi g\u00e2y t\u1eed vong \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o. Tr\u01b0\u1eddng h\u1ee3p x\u1ea3y ra c\u00e1c ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn nghi\u00eam tr\u1ecdng, ng\u1eebng \u0111i\u1ec1u tr\u1ecb ngay l\u1eadp t\u1ee9c v\u1edbi ceftazidim v\u00e0 ti\u1ebfn h\u00e0nh c\u00e1c bi\u1ec7n ph\u00e1p c\u1ea5p c\u1ee9u \u0111\u1ea7y \u0111\u1ee7.<\/p>\n<p>Tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb, n\u00ean h\u1ecfi k\u1ef9 b\u1ec7nh nh\u00e2n v\u1ec1 ti\u1ec1n s\u1eed c\u00e1c ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn v\u1edbi ceftazidim, v\u1edbi c\u00e1c kh\u00e1ng sinh nh\u00f3m cephalosporin ho\u1eb7c v\u1edbi c\u00e1c kh\u00e1ng sinh nh\u00f3m beta-lactam. Th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng cho b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed x\u1ea3y ra c\u00e1c ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn kh\u00f4ng nghi\u00eam tr\u1ecdng v\u1edbi b\u1ea5t k\u1ef3 c\u00e1c thu\u1ed1c nh\u00f3m beta-lactam kh\u00e1c.<\/p>\n<p><em>Ph\u1ed5 t\u00e1c d\u1ee5ng:<\/em><\/p>\n<p>Ceftazidim c\u00f3 ph\u1ed5 kh\u00e1ng khu\u1ea9n h\u1ea1n ch\u1ebf. Thu\u1ed1c kh\u00f4ng th\u00edch h\u1ee3p s\u1eed d\u1ee5ng \u0111\u01a1n \u0111\u1ed9c \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m tr\u00f9ng tr\u1eeb khi m\u1ea7m b\u1ec7nh \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn v\u00e0 \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn l\u00e0 nh\u1ea1y c\u1ea3m v\u1edbi ceftazidim ho\u1eb7c c\u00f3 nghi ng\u1edd cao r\u1eb1ng h\u1ea7u h\u1ebft c\u00e1c m\u1ea7m b\u1ec7nh th\u00edch h\u1ee3p \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb v\u1edbi ceftazidim. \u0110i\u1ec1u \u0111\u1eb7c bi\u1ec7t n\u00e0y \u00e1p d\u1ee5ng khi xem x\u00e9t \u0111i\u1ec1u tr\u1ecb cho b\u1ec7nh nh\u00e2n b\u1ecb nhi\u1ec5m khu\u1ea9n huy\u1ebft, vi\u00eam m\u00e0ng n\u00e3o do vi khu\u1ea9n, nhi\u1ec5m tr\u00f9ng da, m\u00f4 m\u1ec1m v\u00e0 nhi\u1ec5m tr\u00f9ng x\u01b0\u01a1ng, kh\u1edbp. Ngo\u00e0i ra, ceftazidim d\u1ec5 b\u1ecb th\u1ee7y ph\u00e2n b\u1edfi c\u00e1c beta-lactamase ph\u1ed5 r\u1ed9ng (ESBLs). Do \u0111\u00f3, c\u00e1c th\u00f4ng tin v\u1ec1 t\u1ef7 l\u1ec7 c\u00e1c vi sinh v\u1eadt s\u1ea3n xu\u1ea5t ESBLs n\u00ean \u0111\u01b0\u1ee3c l\u01b0u \u00fd khi l\u1ef1a ch\u1ecdn ceftazidim \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p><em>Vi\u00eam k\u1ebft ru\u00f4t gi\u1ea3 mac <\/em><\/p>\n<p>Vi\u00eam \u0111\u1ea1i tr\u00e0ng v\u00e0 vi\u00eam \u0111\u1ea1i tr\u00e0ng gi\u1ea3 m\u1ea1c do vi khu\u1ea9n \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o v\u1edbi h\u1ea7u h\u1ebft c\u00e1c thu\u1ed1c kh\u00e1ng khu\u1ea9n, bao g\u1ed3m c\u1ea3 ceftazidim v\u00e0 c\u00f3 th\u1ec3 x\u1ea3y ra v\u1edbi m\u1ee9c \u0111\u1ed9 nh\u1eb9 \u0111\u1ebfn \u0111e d\u1ecda t\u00ednh m\u1ea1ng. Do \u0111\u00f3, c\u1ea7n ph\u1ea3i xem x\u00e9t tr\u01b0\u1eddng h\u1ee3p n\u00e0y \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 bi\u1ec3u hi\u1ec7n ti\u00eau ch\u1ea3y trong ho\u1eb7c sau khi \u0111i\u1ec1u tr\u1ecb v\u1edbi ceftazidim. C\u1ea7n xem x\u00e9t ng\u01b0ng \u0111i\u1ec1u tr\u1ecb v\u1edbi ceftazidim v\u00e0 ti\u1ebfn h\u00e0nh c\u00e1c bi\u1ec7n ph\u00e1p \u0111i\u1ec1u tr\u1ecb \u0111\u1eb7c hi\u1ec7u v\u1edbi Clostridium difficile. Kh\u00f4ng n\u00ean d\u00f9ng c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf nhu \u0111\u1ed9ng ru\u1ed9t.<\/p>\n<p><em>Ch\u1ee9c n\u0103ng th\u1eadn:<\/em><\/p>\n<p>\u0110i\u1ec1u tr\u1ecb \u0111\u1ed3ng th\u1eddi li\u1ec1u cao c\u00e1c cephalosporin v\u00e0 thu\u1ed1c g\u00e2y \u0111\u1ed9c th\u1eadn nh\u01b0 aminoglycosid ho\u1eb7c thu\u1ed1c l\u1ee3i ti\u1ec3u t\u00e1c d\u1ee5ng m\u1ea1nh (nh\u01b0 furosemid) c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng nghi\u00eam tr\u1ecdng ch\u1ee9c n\u0103ng th\u1eadn<\/p>\n<p>Ceftazidim \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i qua th\u1eadn, do \u0111\u00f3 n\u00ean gi\u1ea3m li\u1ec1u t\u00f9y theo m\u1ee9c \u0111\u1ed9 suy th\u1eadn. C\u1ea7n theo d\u00f5i ch\u1eb7t ch\u1ebd t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn. Bi\u1ebfn ch\u1ee9ng th\u1ea7n kinh \u0111\u00f4i khi \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o khi li\u1ec1u d\u00f9ng kh\u00f4ng \u0111\u01b0\u1ee3c gi\u1ea3m \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb suy th\u1eadn.<\/p>\n<p><em>S\u1ef1 ph\u00e1t tri\u1ec3n qu\u00e1 m\u1ee9c \u1edf c\u00e1c vi sinh v\u1eadt kh\u00f4ng nh\u1ea1y c\u1ea3m:<\/em><\/p>\n<p>S\u1eed d\u1ee5ng k\u00e9o d\u00e0i c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n qu\u00e1 m\u1ee9c c\u1ee7a c\u00e1c ch\u1ee7ng vi sinh v\u1eadt kh\u00f4ng nh\u1ea1y c\u1ea3m (nh\u01b0 Enterococci, n\u1ea5m). \u0110i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 ph\u1ea3i ng\u1eebng \u0111i\u1ec1u tr\u1ecb ho\u1eb7c ti\u1ebfn h\u00e0nh c\u00e1c bi\u1ec7n ph\u00e1p th\u00edch h\u1ee3p kh\u00e1c. \u0110\u00e1nh gi\u00e1 l\u1eb7p l\u1ea1i t\u00ecnh tr\u1ea1ng c\u1ee7a b\u1ec7nh nh\u00e2n l\u00e0 c\u1ea7n thi\u1ebft.<\/p>\n<p><em>C\u00e1c t\u00e1c \u0111\u1ed9ng tr\u1ebdn x\u00e9t nghi\u00eam v\u00e0 \u0111inh l\u01b0\u1ee3ng:<\/em><\/p>\n<p>Ceftazidim kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn c\u00e1c x\u00e9t nghi\u1ec7m glucose ni\u1ec7u b\u1eb1ng enzym nh\u01b0ng c\u00f3 th\u1ec3 c\u00f3 ph\u1ea3n \u1ee9ng d\u01b0\u01a1ng t\u00ednh gi\u1ea3 v\u1edbi c\u00e1c x\u00e9t nghi\u1ec7m b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p kh\u1eed \u0111\u1ed3ng (dung d\u1ecbch Benedict, dung d\u1ecbch Fehling, vi\u00ean Clinitest).<\/p>\n<p>Ceftazidim kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn \u0111\u1ecbnh l\u01b0\u1ee3ng creatinin b\u1eb1ng picrat ki\u1ec1m.<\/p>\n<p>Ceftazidim c\u00f3 th\u1ec3 g\u00e2y d\u01b0\u01a1ng t\u00ednh gi\u1ea3 v\u1edbi ph\u00e9p th\u1eed Coomb \u1edf kho\u1ea3ng 5% b\u1ec7nh nh\u00e2n.<\/p>\n<p><em>Thu\u1ed1c c\u00f3 ch\u1ee9a Natri<\/em><\/p>\n<p>Sitacef lg c\u00f3 ch\u1ee9a 118mg Natri carbonat khan.<\/p>\n<p>V\u00ec v\u1eady n\u00ean c\u00e2n nh\u1ea5c khi s\u1eed d\u1ee5ng tr\u00ean c\u00e1c b\u1ec7nh nh\u00e2n v\u1edbi ch\u1ebf \u0111\u1ed9 \u0103n ki\u1ec3m so\u00e1t mu\u1ed1i.<\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 nghi\u00ean c\u1ee9u n\u00e0o v\u1ec1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a ceftazidim tr\u00ean kh\u1ea3 n\u0103ng l\u00e1i xe, v\u1eadn h\u00e0nh m\u00e1y. Tuy nhi\u00ean, c\u00f3 th\u1ebf x\u1ea3y ra t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n nh\u01b0 ch\u00f3ng m\u1eb7t g\u00e2y \u1ea3nh h\u01b0\u1edfng \u0111\u00ean kh\u1ea3 n\u0103ng l\u00e1i xe ho\u1eb7c v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n<p><strong>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/strong><\/p>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: B1<\/p>\n<p>US FDA pregnancy category: B<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>C\u00f3 r\u1ea5t \u00edt d\u1eef li\u1ec7u v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng ceftazidim tr\u00ean ph\u1ee5 n\u0169&#8217; c\u00f3 thai. C\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt kh\u00f4ng th\u1ea5y c\u00e1c t\u00e1c d\u1ee5ng c\u00f3 h\u1ea1i tr\u1ef1c ti\u1ebfp ho\u1eb7c gi\u00e1n ti\u1ebfp tr\u00ean ph\u1ee5 n\u1eef c\u00f3 thai, s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a thai nhi\/b\u00e0o thai, qu\u00e1 tr\u00ecnh sinh v\u00e0 sau sinh (xem ph\u1ea7n d\u1eef li\u1ec7u ti\u1ec1n l\u00e3m s\u00e0ng).<\/p>\n<p>Ch\u1ec9 s\u1eed d\u1ee5ng ceftazidim cho ph\u1ee5 n\u1eef c\u00f3 thai khi c\u00e2n nh\u1eafc th\u1ea5y l\u1ee3i \u00edch nhi\u1ec1u h\u01a1n nguy c\u01a1<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>Ceftazidim \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua s\u1eefa m\u1eb9 v\u1edbi l\u01b0\u1ee3ng nh\u1ecf nh\u01b0ng kh\u00f4ng c\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn tr\u1ebb b\u00fa m\u1eb9 \u1ecf&#8217; li\u1ec1u \u0111i\u1ec1u tr\u1ecb. Do v\u1eady, c\u00f3 th\u1ec3 d\u00f9ng ceftazidim trong th\u1eddi gian cho con b\u00fa.<\/p>\n<p><em>Kh\u1ea3 n\u0103ng sinh s\u1ea3n<\/em><\/p>\n<p>Kh\u00f4ng c\u00f3 d\u1eef li\u1ec7u<\/p>\n<p><strong>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/strong><\/p>\n<p>T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n th\u01b0\u1eddng g\u1eb7p: t\u0103ng b\u1ea1ch c\u1ea7u, t\u0103ng ti\u1ec3u c\u1ea7u, vi\u00eam t\u0129nh m\u1ea1ch ho\u1eb7c vi\u00eam t\u1eafc t\u0129nh m\u1ea1ch khi d\u00f9ng \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch, ti\u00eau ch\u1ea3y, t\u0103ng enzyme gan t\u1ea1m th\u1eddi, ban d\u00e1t ho\u1eb7c ban m\u00ea \u0111ay, \u0111au v\u00e0\/ho\u1eb7c vi\u00eam sau khi ti\u00eam b\u1eafp v\u00e0 test Comb d\u01b0\u01a1ng t\u00ednh.<\/p>\n<p>D\u1eef li\u1ec7u t\u1eeb c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng \u0111\u01b0\u1ee3c t\u00e0i tr\u1ee3 v\u00e0 kh\u00f4ng \u0111\u01b0\u1ee3c t\u00e0i tr\u1ee3 cho th\u1ea5y t\u1ea7n su\u1ea5t th\u01b0\u1eddng g\u1eb7p v\u00e0 kh\u00f4ng th\u01b0\u1eddng g\u1eb7p c\u1ee7a c\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n:<\/p>\n<p>Th\u01b0\u1eddng g\u1eb7p: \u2265 1\/100 \u0111\u1ebfn &lt; 1\/10.<\/p>\n<p>\u00cdt g\u1eb7p: \u2265 1\/1.000 \u0111\u1ebfn &lt; 1\/100.<\/p>\n<p>Hi\u1ebfm g\u1eb7p: \u2265 1\/10.000 \u0111\u1ebfn &lt; 1\/1.000.<\/p>\n<p>R\u1ea5t hi\u1ebfm g\u1eb7p: &lt; 1\/10.000.<\/p>\n<p>Kh\u00f4ng bi\u1ebft \u0111\u1ebfn: kh\u00f4ng \u01b0\u1edbc t\u00ednh t\u1eeb d\u1eef li\u1ec7u c\u00f3 s\u1eb5n.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"535\" class=\"wp-image-18414\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-298.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-298.png 600w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-298-300x268.png 300w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-298-179x160.png 179w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"509\" class=\"wp-image-18415\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-299.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-299.png 600w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-299-300x255.png 300w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-299-189x160.png 189w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"601\" height=\"575\" class=\"wp-image-18417\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-300.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-300.png 601w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-300-300x287.png 300w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-300-600x574.png 600w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-300-167x160.png 167w\" sizes=\"auto, (max-width: 601px) 100vw, 601px\" \/><\/p>\n<p>Ghi ch\u00fa:<\/p>\n<p>(1): \u0110\u00e3 c\u00f3 b\u00e1o c\u00e1o v\u1ec1 di ch\u1ee9ng th\u1ea7n kinh g\u1ed3m: run, ch\u1ee9ng gi\u1eadt run c\u01a1, co gi\u1eadt, b\u1ec7nh n\u00e3o v\u00e0 h\u00f4n m\u00ea \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn m\u00e0 li\u1ec1u d\u00f9ng c\u1ee7a ceftazidim kh\u00f4ng \u0111\u01b0\u1ee3c gi\u1ea3m th\u00edch h\u1ee3p.<\/p>\n<p>(2): Ti\u00eau ch\u1ea3y v\u00e0 vi\u00eam \u0111\u1ea1i tr\u00e0ng do Clostridium difficile v\u00e0 c\u00f3 th\u1ec3 x\u1ea3y ra vi\u00eam \u0111\u1ea1i tr\u00e0ng gi\u1ea3 m\u1ea1c.<\/p>\n<p>(3): ALT (SGPT), AST (SOGT), LDH, GGT, phosphatase ki\u1ec1m.<\/p>\n<p>(4): Hi\u1ebfm c\u00f3 b\u00e1o c\u00e1o h\u1ed9i ch\u1ee9ng Dress li\u00ean quan \u0111\u1ebfn ceftazidim.<\/p>\n<p>(5): Th\u1eed nghi\u1ec7m Coomb d\u01b0\u01a1ng t\u00ednh c\u00f3 th\u1ec3 x\u1ea3y ra \u1edf kho\u1ea3ng 5% b\u1ec7nh nh\u00e2n v\u00e0 c\u00f3 th\u1ec3 can thi\u1ec7p v\u1edbi ph\u1ea3n \u1ee9ng ch\u00e9o trong m\u00e1u.<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<p><strong>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/strong><\/p>\n<p>Ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c. V\u1edbi c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i nh\u1eb9, th\u01b0\u1eddng ch\u1ec9 c\u1ea7n ng\u1eebng thu\u1ed1c. Tr\u01b0\u1eddng h\u1ee3p m\u1eabn c\u1ea3m n\u1eb7ng ho\u1eb7c ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, c\u1ea7n ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 (gi\u1eef tho\u00e1ng kh\u00ed v\u00e0 d\u00f9ng epinephrin, th\u1edf oxygen, d\u00f9ng kh\u00e1ng histamin, corticoid&#8230;).<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/strong><\/p>\n<p>C\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 t\u01b0\u01a1ng t\u00e1c thu\u1ed1c m\u1edbi ch\u1ec9 th\u1ef1c hi\u1ec7n v\u1edbi probenecid v\u00e0 furosemide.<\/p>\n<p>S\u1eed d\u1ee5ng \u0111\u1ed3ng th\u00f2i cefitazidim v\u1edbi li\u1ec1u cao c\u00e1c thu\u1ed1c g\u00e2y \u0111\u1ed9c th\u1eadn c\u00f3 th\u1ec3 g\u00e2y h\u1ea1i cho ch\u1ee9c n\u0103ng th\u1eadn (xem ph\u1ea7n C\u1ea3nh b\u00e1o v\u00e0 th\u1eadn tr\u1ecdng).<\/p>\n<p>Chloramphenicol \u0111\u1ed1i v\u1eadn v\u1edbi ceftazidim v\u00e0 c\u00e1c kh\u00e1ng sinh cephalosporin kh\u00e1c tr\u00ean in vitro. S\u1ef1 li\u00ean quan l\u00e2m s\u00e0ng c\u1ee7a hi\u1ec7n t\u01b0\u1ee3ng n\u00e0y v\u1eabn ch\u01b0a gi\u1ea3i th\u00edch, nh\u01b0ng n\u1ebfu d\u00f9ng \u0111\u1ed3ng th\u1eddi ceftazidim v\u00e0 chloramphenicol th\u00ec n\u00ean c\u00e2n nh\u1eafc t\u1edbi kh\u1ea3 n\u0103ng x\u1ea3y ra t\u01b0\u01a1ng t\u00e1c \u0111\u1ed1i v\u1eadn.<\/p>\n<p>Ceftazidim c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m h\u1ea5p thu thu\u1ed1c tr\u00e1nh thai \u0111\u01b0\u1eddng u\u1ed1ng.<\/p>\n<p><strong>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/strong><\/p>\n<p>Qu\u00e1 li\u1ec1u c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn di ch\u1ee9ng th\u1ea7n kinh bao g\u1ed3m b\u1ec7nh n\u00e3o, co gi\u1eadt v\u00e0 h\u00f4n m\u00ea.<\/p>\n<p>C\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a qu\u00e1 li\u1ec1u c\u00f3 th\u1ec3 x\u1ea3y ra n\u1ebfu c\u00e1c li\u1ec1u kh\u00f4ng \u0111\u01b0\u1ee3c gi\u1ea3m m\u1ed9t c\u00e1ch th\u00edch h\u1ee3p \u1ecf&#8217; nh\u1eefng b\u1ec7nh nh\u00e2n suy th\u1eadn (xem ph\u1ea7n 4.2 v\u00e0 4.4).<\/p>\n<p>N\u1ed3ng \u0111\u1ed9 ceftazidime c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c gi\u1ea3m b\u1eb1ng c\u00e1ch th\u1ea9m ph\u00e2n m\u00e1u ho\u1eb7c th\u1ea9m ph\u00e2n ph\u00fac m\u1ea1c.<\/p>\n<p><strong>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/strong><\/p>\n<p><strong>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/strong><\/p>\n<p>M\u00e3 ATC: J01DD02.<\/p>\n<p>Nh\u00f3m d\u01b0\u1ee3c l\u00fd: Kh\u00e1ng sinh nh\u00f3m cephalosporin th\u1ebf h\u1ec7 3.<\/p>\n<p><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng:<\/em><\/p>\n<p>Ceftazidim \u1ee9c ch\u1ebf s\u1ef1 sinh t\u1ed5ng h\u1ee3p th\u00e0nh t\u1ebf b\u00e0o vi khu\u1ea9n d\u1ef1a tr\u00ean s\u1ef1 g\u1eafn k\u1ebft v\u1edbi protein li\u00ean k\u1ebft penicillin. K\u00eat qu\u1ea3 l\u00e0 gi\u00e1n \u0111o\u1ea1n sinh t\u00f4ng h\u1ee3p th\u00e0nh t\u1ebf b\u00e0o d\u1eabn t\u1edbi ti\u00eau th\u00e0nh t\u1ebf b\u00e0o v\u00e0 l\u00e0m ch\u1ebft vi khu\u1ea9n<\/p>\n<p><em>Quan h\u1ec7 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\/d\u01b0\u1ee3c l\u1ef1c h\u1ecdc (PK\/PD):<\/em><\/p>\n<p>V\u1edbi c\u00e1c cephalosporin, ch\u1ec9 s\u1ed1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\/ d\u01b0\u1ee3c l\u1ef1c h\u1ecdc quan tr\u1ecdng nh\u1ea5t li\u00ean quan t\u1edbi hi\u1ec7u qu\u1ea3 tr\u00ean in vivo \u0111\u01b0\u1ee3c th\u00e2y l\u00e0 ph\u00e2n tr\u0103m thu\u1ed1c kh\u00f4ng g\u1eafn k\u1ebft gi\u1eefa c\u00e1c kho\u1ea3ng c\u00e1ch li\u1ec1u v\u1eabn duy tr\u00ec cao h\u01a1n n\u1ed3ng \u0111\u1ed9 \u1ee9c ch\u1ebf t\u1ed1i thi\u1ec3u (MIC).<\/p>\n<p><em>C\u01a1 ch\u1ebf kh\u00e1ng thu\u1ed1c:<\/em><\/p>\n<p>S\u1ef1 kh\u00e1ng kh\u00e1ng sinh c\u1ee7a vi khu\u1ea9n v\u1edbi ceftazidim c\u00f3 th\u1ec3 do m\u1ed9t ho\u1eb7c c\u00e1c c\u01a1 ch\u1ebf sau:<\/p>\n<p>S\u1ef1 ly gi\u1ea3i men beta-lactamase. Ceftazidim c\u00f3 th\u1ec3 b\u1ecb ly gi\u1ea3i b\u1ecfi c\u00e1c men beta-lactamase ph\u1ed5 r\u1ed9ng (ESBL), bao g\u1ed3m SHV v\u00e0 c\u00e1c enzym AmpC c\u00f3 th\u1ec3 l\u00e0m \u1ee9c ch\u1ebf ho\u1eb7c l\u00e0m y\u1ebfu \u0111i \u1edf m\u1ed9t s\u1ed1 lo\u00e0i vi khu\u1ea9n Gram (-).<\/p>\n<p>Gi\u1ea3m s\u1ef1 g\u1eafn k\u1ebft c\u1ee7a c\u00e1c protein g\u1eafn k\u1ebft penicillin v\u1edbi ceftazidim<\/p>\n<p>T\u00ednh kh\u00f4ng th\u1ea5m c\u1ee7a m\u00e0ng ngo\u00e0i ng\u0103n s\u1ef1 ti\u1ebfp c\u1eadn c\u1ee7a ceftazidim v\u1edbi c\u00e1c protein g\u1eafn k\u1ebft penicillin \u1edf c\u00e1c vi khu\u1ea9n Gram (-).<\/p>\n<p>C\u00e1c b\u01a1m th\u1ee5 \u0111\u1ed9ng \u1edf vi khu\u1ea5n.<\/p>\n<p><em>S\u1ef1 nh\u1ea1y c\u1ea3m v\u1ec9 sinh v\u1eadt:<\/em><\/p>\n<p>S\u1ef1 ph\u1ed5 bi\u1ebfn kh\u00e1ng thu\u1ed1c m\u1eafc ph\u1ea3i c\u00f3 th\u1ebf kh\u00e1c nhau theo \u0111\u1ecba l\u00fd v\u00e0 th\u1eddi gian v\u1edbi m\u1ed9t s\u1ed1 vi khu\u1ea9n \u0111\u01b0\u1ee3c l\u1ef1a ch\u1ecdn v\u00e0 th\u00f4ng tin kh\u00e1ng thu\u1ed1c theo v\u00f9ng, \u0111\u1eb7c bi\u1ec7t khi \u0111i\u1ec1u tr\u1ecb c\u00e1c nhi\u1ec5m tr\u00f9ng n\u1eb7ng. Khi c\u1ea7n thi\u1ebft, n\u00ean t\u01b0 v\u1ea5n \u00fd ki\u1ebfn chuy\u00ean gia khi m\u00e0 s\u1ef1 ph\u1ed5 bi\u1ebfn kh\u00e1ng thu\u1ed1c \u1edf \u0111\u1ecba ph\u01b0\u01a1ng \u0111\u1ebfn m\u1ee9c m\u00e0 l\u1ee3i \u00edch c\u1ee7a ceftazldim tr\u00ean m\u1ed9t s\u1ed1 vi khu\u1ea9n v\u1eabn ch\u01b0a ch\u1eafc ch\u1eafn<\/p>\n<p><em>C\u00e1c ch\u1ee7ng th\u01b0\u1eddng l\u00e0 nhay c\u1ea3m:<\/em><\/p>\n<p>Vi khu\u1ea9n hi\u1ebfu kh\u00ed Gram (+): Streptococcus pyogenes, Streptococcus agalactiae.<\/p>\n<p>Vi khu\u1ea9n hi\u1ebfu kh\u00ed Gram (-): Citrobacter koseri, Citrobacter koseri, Haemophilus influenzae, Moraxella catarrhalis, Neisseria menigitidis, Pasteurella multocida, Proteus mirabilis, Proteus spp (other), Providencia spp.<\/p>\n<p>C\u00e1c ch\u1ee7ng m\u00e0 kh\u00e1ng thu\u1ed1c m\u1eafc ph\u1ea3i c\u00f3 th\u1ebf ph\u1ea3i c\u00e2n nh\u1eafc<\/p>\n<p>Vi khu\u1ea9n hi\u1ebfu kh\u00ed gram (-): Acinetobacter baumannii Burkholderia cepacia, Citrobacter freundii, Enterobacter aerogenes, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, Klebsiella spp (other), Pseudomonas aeruginosa, Serratia spp, Morganella morgana.<\/p>\n<p>Vi khu\u1ea9n hi\u1ebfu kh\u00ed Gram (+): Staphylococcus aureus1, Staphylococcus pneumoniaeLl Viridans group streptococcus<\/p>\n<p>Vi khu\u1ea9n k\u1ecb kh\u00ed Gram (+): Clostridiumperfringens, Peptostreptococcus spp.<\/p>\n<p>Vi khu\u1ea9n k\u1ecb kh\u00ed Gram (-): Fusobacterium spp.<\/p>\n<p>C\u00e1c vi sinh v\u00e2t kh\u00e1ng thu\u1ed1c di truy\u1ec1n:<\/p>\n<p>Vi khu\u00e2n hi\u1ebfu kh\u00ed Gram (+): C\u00e1c ch\u1ee7ng Enterococcus spp bao g\u1ed3m Enterococcus faecalis v\u00e0 Enterococcus faecium. Listeria spp.<\/p>\n<p>Vi khu\u1ea9n k\u1ecb kh\u00ed Gram (+): Clostridium difficile<\/p>\n<p>Vi khu\u00e2n k\u1ecb kh\u00ed Gram (-): Bacteroides spp. (nhi\u1ec1u ch\u1ee7ng Bactero\u00ecdes fragilis kh\u00e1ng thu\u1ed1c).<\/p>\n<p>C\u00e1c ch\u1ee7ng kh\u00e1c: Chlamydia spp., Mycoplasma spp., Legionella spp<\/p>\n<p>Ghi ch\u00fa:<\/p>\n<p>(1): S. aureus nh\u1ea1y c\u1ea3m v\u1edbi methicillin \u0111\u01b0\u1ee3c xem l\u00e0 c\u00f3 t\u00ednh nh\u1ea1y c\u1ea3m th\u1ea5p v\u1edbi ceftazidim. T\u1ea5t c\u1ea3 c\u00e1c lo\u1ea1i S. aureus kh\u00e1ng methicillin \u0111\u1ec1u kh\u00e1ng v\u1edbi ceftazidim.<\/p>\n<p>(2): S.pneumoniae \u0111\u00e3 ch\u1ee9ng minh nh\u1ea1y c\u1ea3m trung b\u00ecnh ho\u1eb7c kh\u00e1ng v\u1edbi penicillin c\u00f3 th\u1ec3 d\u1ef1 ki\u1ebfn \u00edt nh\u1ea5t t\u00ednh nh\u1ea1y c\u1ea3m b\u1ecb gi\u1ea3m v\u1edbi ceftazidim<\/p>\n<p>T\u1ef7 l\u1ec7 kh\u00e1ng thu\u1ed1c cao \u0111\u01b0\u1ee3c quan s\u00e1t \u1edf m\u1ed9t ho\u1eb7c nhi\u1ec1u v\u00f9ng\/qu\u1ed1c gia\/khu v\u1ef1c \u1edd ch\u00e2u \u00c2u.<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>Ceftazidim l\u00e0 m\u1ed9t kh\u00e1ng sinh cephalosporin th\u1ebf h\u1ec7 3 c\u00f3 t\u00e1c d\u1ee5ng di\u1ec7t khu\u1ea5n do \u1ee9c ch\u1ebf c\u00e1c enzym t\u1ed5ng h\u1ee3p th\u00e0nh t\u1ebf b\u00e0o vi khu\u1ea5n.<\/p>\n<p><a href=\"https:\/\/www.youtube.com\/watch?v=0TIIfoiJFwA\"><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/a><\/p>\n<p><strong>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/strong><\/p>\n<p><em>H\u1ea5p thu<\/em><\/p>\n<p>Sau khi ti\u00eam b\u1eafp 500mg ho\u1eb7c lg ceftazidim, n\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trong huy\u1ebft t\u01b0\u01a1ng nhanh ch\u00f3ng \u0111\u1ea1t \u0111\u01b0\u1ee3c t\u01b0\u01a1ng \u1ee9ng l\u00e0 18 v\u00e0 37mg\/L. 5 ph\u00fat sau khi ti\u00eam bolus t\u0129nh m\u1ea1ch li\u1ec1u 500mg, lg v\u00e0 2g, n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng t\u01b0ong \u1ee9ng l\u00e0 46, 87 v\u00e0 170mg\/L. \u0110\u1ed9ng h\u1ecdc c\u1ee7a ceftazidim tuy\u1ebfn t\u00ednh trong kho\u1ea3ng li\u1ec1u \u0111\u01a1n l\u00e0 0.5 -2g theo \u0111\u01b0\u00f2ng ti\u00eam b\u1eafp ho\u1eb7c t\u0129nh m\u1ea1ch.<\/p>\n<p><em>Ph\u00e2n b\u1ed1<\/em><\/p>\n<p>Ceftazidim g\u1eafn k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng th\u1ea5p, kho\u1ea3ng 10%. N\u1ed3ng \u0111\u1ed9 v\u01b0\u1ee3t n\u1ed3ng \u0111\u1ed9 \u1ee9c ch\u1ebf t\u1ed1i thi\u1ec3u (MIC) v\u1edbi c\u00e1c t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh th\u01b0\u1eddng g\u1eb7p c\u00f3 th\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c \u1edf c\u00e1c m\u00f4 nh\u01b0 x\u01b0\u01a1ng, tim, m\u1eadt, n\u01b0\u1edbc b\u1ecdt, th\u1ee7y d\u1ecbch, ho\u1ea1t d\u1ecbch v\u00e0 d\u1ecbch m\u00e0ng b\u1ee5ng. Ceftazidim d\u1ec5 d\u00e0ng \u0111i qua nhau thai v\u00e0 th\u1ea3i tr\u1eeb qua s\u1eefa m\u1eb9. R\u1ea5t \u00edt \u0111i qua h\u00e0ng r\u00e0o m\u00e1u n\u00e3o c\u00f2n nguy\u00ean v\u1eb9n, n\u1ed3ng \u0111\u1ed9 nh\u1ecf ceftazidim trong d\u1ecbch n\u00e3o t\u1ee7y (CSF) khi c\u00f3 vi\u00eam. Tuy nhi\u00ean, khi m\u00e0ng n\u00e3o b\u1ecb vi\u00eam, n\u1ed3ng \u0111\u1ed9 \u0111\u1ea1t \u0111\u01b0\u1ee3c trong d\u1ecbch n\u00e3o t\u1ee7y l\u00e0 4 &#8211; 20 mg\/L ho\u1eb7c nhi\u1ec1u hon.<\/p>\n<p><em>Chuy\u1ec3n h\u00f3<\/em><\/p>\n<p>Ceftazidim kh\u00f4ng b\u1ecb chuy\u1ec3n h\u00f3a.<\/p>\n<p><em>Th\u1ea3i tr\u1eeb<\/em><\/p>\n<p>N\u1ed3ng \u0111\u1ed9 sau khi ti\u00eam thu\u1ed1c gi\u1ea3m v\u1edbi th\u1eddi gian b\u00e1n th\u1ea3i l\u00e0 2 gi\u1edd. Ceftazidim \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb qua n\u01b0\u1edbc ti\u1ec3u th\u00f4ng qua l\u1ecdc c\u1ea7u th\u1eadn \u1edf d\u1ea1ng kh\u00f4ng \u0111\u1ed5i; kho\u1ea3ng 80 &#8211; 90% li\u1ec1u d\u00f9ng \u0111\u01b0\u1ee3c t\u00e1i h\u1ea5p thu t\u1eeb n\u01b0\u1edbc ti\u1ec3u trong 24 gi\u1edd. \u00edt h\u01a1n 1% thu\u1ed1c th\u1ea3i tr\u1eeb qua m\u1eadt.<\/p>\n<p>\u0110\u1ed1i t\u01b0\u1ee3ng d\u00e2n s\u1ed1 \u0111\u1eb7c bi\u1ec7t B\u00eanh nh\u00e2n suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u00e2n<\/p>\n<p>Th\u1ea3i tr\u1eeb ceftazidim gi\u1ea3m \u1edf c\u00e1c b\u1ec7nh nh\u00e2n suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn v\u00e0 n\u00ean gi\u1ea3m li\u1ec1u (xem ph\u1ea7n Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch d\u00f9ng).<\/p>\n<p><em>B\u00eanh nh\u00e2n suy gi\u1ea3m ch\u1ee9c n\u0103ng gan<\/em><\/p>\n<p>Suy gi\u1ea3m ch\u1ee9c n\u0103ng gan nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh kh\u00f4ng \u1ea3nh h\u01b0\u1ecfng \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a ceftazidim v\u1edbi c\u00e1c c\u00e1 th\u00ea \u0111\u01b0\u1ee3c ti\u00eam t\u0129nh m\u1ea1ch 2g m\u1ed7i 8 gi\u1edd trong 5 ng\u00e0y, mi\u00ean l\u00e0 ch\u1ee9c n\u0103ng th\u1eadn v\u00e2n b\u00ecnh th\u01b0\u1eddng (xem ph\u1ea7n Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch d\u00f9ng).<\/p>\n<p><em>Ng\u01b0\u00f2i cao tu\u1ed3i<\/em><\/p>\n<p>Th\u1ea3i tr\u1eeb ceftazidim gi\u1ea3m \u1ecf\u2019 ng\u01b0\u1eddi cao tu\u1ed5i ch\u1ee7 y\u1ebfu do th\u1ea3i tr\u1eeb \u1edf th\u1eadn suy gi\u1ea3m theo tu\u1ed5i. Th\u1eddi gian b\u00e1n th\u1ea3i th\u1ea3i tr\u1eeb trung b\u00ecnh v\u00e0o kho\u1ea3ng 3,5 &#8211; 4 gi\u1edd sau v\u1edbi li\u00eau 2g ti\u00eam t\u0129nh m\u1ea1ch bolus m\u1ed9t l\u00e2n duy nh\u00e2t ho\u1eb7c 2 l\u1ea7n\/ng\u00e0y trong 7 ng\u00e0y \u1ecf&#8217; b\u1ec7nh nh\u00e2n t\u1eeb 80 tu\u1ed5i tr\u1edf l\u00ean.<\/p>\n<p><em>Tr\u1ebb em<\/em><\/p>\n<p>Th\u1eddi gian b\u00e1n th\u1ea3i k\u00e9o d\u00e0i \u1edf tr\u1ebb sinh non v\u00e0 s\u01a1 sinh t\u1eeb 4,5 &#8211; 7,5 gi\u1edd sau c\u00e1c li\u1ec1u t\u1eeb 25 &#8211; 30 mg\/kg c\u00e2n n\u1eb7ng. Tuy nhi\u00ean, th\u1eddi gian b\u00e1n th\u1ea3i t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh v\u1edbi tr\u1ebb t\u1eeb 2 th\u00e1ng tu\u1ed5i<\/p>\n<p><strong>5.3 Gi\u1ea3i th\u00edch: <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong>5.4 Thay th\u1ebf thu\u1ed1c : <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/strong><\/p>\n<p><strong>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/strong><\/p>\n<p>Kh\u00f4ng c\u00f3<\/p>\n<p><strong>6.2. T\u01b0\u01a1ng k\u1ef5 :<\/strong><\/p>\n<p>V\u1edbi dung d\u1ecbch natri bicarbonat: L\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c. Kh\u00f4ng pha ceftazidim v\u00e0o dung d\u1ecbch c\u00f3 pH tr\u00ean 7,5 (kh\u00f4ng \u0111\u01b0\u1ee3c pha thu\u1ed1c v\u00e0o dung d\u1ecbch natri bicarbonat).<\/p>\n<p>Ph\u1ed1i h\u1ee3p v\u1edbi vancomycin ph\u1ea3i ti\u00eam ri\u00eang v\u00ec g\u00e2y k\u1ebft t\u1ee7a.<\/p>\n<p>Kh\u00f4ng pha l\u1eabn ceftazidim v\u1edbi c\u00e1c aminoglycosid (gentamicin, streptomycin) ho\u1eb7c metronidazol. Ph\u1ea3i tr\u00e1nh r\u1eeda c\u1ea9n th\u1eadn c\u00e1c \u1ed1ng th\u00f4ng v\u00e0 b\u01a1m ti\u00eam b\u1eb1ng dung d\u1ecbch natri clorid 0,9% gi\u1eefa c\u00e1c l\u1ea7n d\u00f9ng hai lo\u1ea1i thu\u1ed1c n\u00e0y \u0111\u1ec3 tr\u00e1nh g\u00e2y k\u1ebft t\u1ee7a.<\/p>\n<p><strong>6.3. B\u1ea3o qu\u1ea3n: <\/strong><\/p>\n<p>N\u01a1i kh\u00f4, nhi\u1ec7t \u0111\u1ed9 kh\u00f4ng qu\u00e1 300C, tr\u00e1nh \u00e1nh s\u00e1ng.<\/p>\n<p>Dung d\u1ecbch ti\u00eam b\u1eafp (N\u1ed3ng \u0111\u1ed9 kho\u1ea3ng 250 mg ceftazidim\/ml) pha trong n\u01b0\u1edbc c\u1ea5t ti\u00eam v\u00e0 dung d\u1ecbch lidocain hydroclorid 0,5%: S\u1eed d\u1ee5ng trong v\u00f2ng 18 gi\u1edd b\u1ea3o qu\u1ea3n \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng.<\/p>\n<p>Dung d\u1ecbch ti\u00eam t\u0129nh m\u1ea1ch (N\u1ed3ng \u0111\u1ed9 100 mg ceftazidim\/ml ho\u1eb7c th\u1ea5p hon) pha trong n\u01b0\u1edbc c\u1ea5t ti\u00eam, dung d\u1ecbch natri clorid 0,9%, dung d\u1ecbch dextrose 5%: S\u1eed d\u1ee5ng trong v\u00f2ng 24 gi\u1edd b\u1ea3o qu\u1ea3n \u1edf nhi\u1ec7t \u0111\u1ed9 ph\u00f2ng.<\/p>\n<p>Ceftazidim k\u00e9m b\u1ec1n v\u1eefng trong dung d\u1ecbch natri bicarbonat.<\/p>\n<p><strong>6.4. Th\u00f4ng tin kh\u00e1c :<\/strong><\/p>\n<p><em>D\u1eef li\u1ec7u an to\u00e0n ti\u1ec1n l\u00e2m s\u00e0ng<\/em><\/p>\n<p>D\u1eef li\u1ec7u ti\u1ec1n l\u00e2m s\u00e0ng cho th\u1ea5y kh\u00f4ng c\u00f3 nguy c\u01a1 c\u00f3 h\u1ea1i n\u00e0o v\u1edbi con ng\u01b0\u1eddi d\u1ef1a tr\u00ean c\u00e1c nghi\u00ean c\u1ee9u d\u01b0\u1ee3c l\u00fd h\u1ecdc an to\u00e0n, \u0111\u1ed9c t\u1ed1 li\u1ec1u l\u1eb7p l\u1ea1i, g\u00e2y \u0111\u1ed9c v\u1edbi gen, g\u00e2y \u0111\u1ed9c v\u1edbi sinh s\u1ea3n. C\u00e1c nghi\u00ean c\u1ee9u tr\u00ean y\u00eau t\u00f4 g\u00e2y ung th\u01b0 ch\u01b0a \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n v\u1edbi ceftazidim<\/p>\n<p><strong>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/strong><\/p>\n<p>D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Ceftazidime Ph\u00e2n lo\u1ea1i: Thu\u1ed1c Kh\u00e1ng sinh nh\u00f3m cephalosporin th\u1ebf h\u1ec7 3. Nh\u00f3m ph\u00e1p l\u00fd: Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine) M\u00e3 ATC (Anatomical Therapeutic Chemical): J01DD02. Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c: FORTUM Bi\u1ec7t d\u01b0\u1ee3c: Sitacef H\u00e3ng s\u1ea3n xu\u1ea5t : Laboratorio Internacional [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":18413,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[621],"class_list":["post-18412","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-ceftazidime"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/18412","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=18412"}],"version-history":[{"count":3,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/18412\/revisions"}],"predecessor-version":[{"id":50262,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/18412\/revisions\/50262"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/18413"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=18412"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=18412"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=18412"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}