{"id":18365,"date":"2020-05-13T13:58:21","date_gmt":"2020-05-13T06:58:21","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=18365"},"modified":"2025-01-08T20:58:42","modified_gmt":"2025-01-08T13:58:42","slug":"ceftazidime-hwazim-hudizim-domrid","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/ceftazidime-hwazim-hudizim-domrid\/","title":{"rendered":"Ceftazidime &#8211; Hwazim\/Hudizim\/Domrid"},"content":{"rendered":"<p><strong>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: <\/strong><\/p>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <a href=\"https:\/\/pharmog.com\/wp\/ceftazidime\/\">Ceftazidime<\/a><\/strong><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u1ed1c Kh\u00e1ng sinh nh\u00f3m cephalosporin th\u1ebf h\u1ec7 3.<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): J01DD02.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em> <a href=\"https:\/\/pharmog.com\/wp\/ceftazidime-fortum\/\">FORTUM<\/a><\/strong><\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c:<\/em><\/strong> Hwazim Inj, Hudizim Inj, Domrid Inj<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: Hwail Pharm. Co., Ltd.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng: <\/strong><\/p>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>L\u1ecd 500 mg, 1 g, 2 g b\u1ed9t v\u00f4 khu\u1ea5n \u0111\u1ec3 pha ti\u00eam ho\u1eb7c ti\u00eam truy\u1ec1n.<\/p>\n<p>H\u00e0m l\u01b0\u1ee3ng v\u00e0 li\u1ec1u l\u01b0\u1ee3ng bi\u1ec3u th\u1ecb theo d\u1ea1ng ceftazidim khan: 1 g ceftazidim khan t\u01b0\u01a1ng \u1ee9ng v\u1edbi 1,16 g ceftazidim pentahydrat.<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>HWAZIM INJ 1g<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i l\u1ecd thu\u1ed1c b\u1ed9t pha ti\u00eam c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Ceftazidime Natri<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>1000 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"363\" height=\"176\" class=\"wp-image-18366\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-274.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-274.png 363w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-274-300x145.png 300w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-274-280x136.png 280w\" sizes=\"auto, (max-width: 363px) 100vw, 363px\" \/><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>HUDIZIM Inj 1g<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i l\u1ecd thu\u1ed1c b\u1ed9t pha ti\u00eam c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Ceftazidime Natri<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>1000 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"496\" height=\"336\" class=\"wp-image-18367\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-275.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-275.png 496w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-275-300x203.png 300w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2020\/05\/word-image-275-236x160.png 236w\" sizes=\"auto, (max-width: 496px) 100vw, 496px\" \/><\/p>\n<p><strong>3. Video by Pharmog:<\/strong><\/p>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe loading=\"lazy\" title=\"[Pharmog SS1 - T\u1eadp 08] - D\u01b0\u1ee3c l\u00fd c\u00e1c thu\u1ed1c kh\u00e1ng sinh\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/0TIIfoiJFwA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<p><strong>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng: <\/strong><\/p>\n<p><strong>4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>Ceftazidim \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh trong \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m khu\u1ea9n b\u1edfi nh\u1eefng ch\u1ee7ng nh\u1ea1y c\u1ea3m c\u1ee7a c\u00e1c vi khu\u1ea9n \u0111\u01b0\u1ee3c tr\u00ecnh b\u00e0y \u1edf ph\u1ea7n d\u01b0\u1ee3c l\u1ef1c h\u1ecdc v\u00e0 ch\u1ec9 khi li\u1ec7u ph\u00e1p ti\u00eam l\u00e0 th\u1ef1c s\u1ef1 c\u1ea7n thi\u1ebft:<\/p>\n<p>Nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p bao g\u1ed3m nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p d\u01b0\u1edbi \u1edf c\u00e1c b\u1ec7nh nh\u00e2n x\u01a1 nang.<\/p>\n<p>Nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u. D\u1ef1 ph\u00f2ng ph\u1eabu thu\u1eadt c\u1eaft tuy\u1ebfn ti\u1ec1n li\u1ec7t qua ng\u00e3 ni\u1ec7u \u0111\u1ea1o.<\/p>\n<p>Nhi\u1ec5m khu\u1ea9n da, m\u00f4 m\u1ec1m, x\u01b0\u01a1ng, kh\u1edbp.<\/p>\n<p>Nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng m\u1eadt.<\/p>\n<p>Nhi\u1ec5m tr\u00f9ng \u1ed5 b\u1ee5ng.<\/p>\n<p>Nhi\u1ec5m khu\u1ea9n li\u00ean quan \u0111\u00ean th\u1ea9m ph\u00e2n ph\u00fac m\u1ea1c.<\/p>\n<p>Vi\u00eam m\u00e0ng n\u00e3o do vi khu\u1ea9n Gram (-) \u00e1i kh\u00ed.<\/p>\n<p><strong>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/strong><\/p>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p>V\u1edbi ti\u00eam b\u1eafp: H\u00f2a tan trong 3,0 ml n\u01b0\u1edbc c\u1ea5t ti\u00eam ho\u1eb7c dung d\u1ecbch ti\u00eam lidocain 0,5% hay 1%. L\u1eafc k\u0129.<\/p>\n<p>V\u1edbi ti\u00eam t\u0129nh m\u1ea1ch: H\u00f2a tan trong 10,0 ml n\u01b0\u1edbc c\u1ea5t ti\u00eam, ho\u1eb7c dung d\u1ecbch NaCl 0,9%, ho\u1eb7c dextrose 5%. L\u1eafc k\u0129.<\/p>\n<p>Dung d\u1ecbch sau khi h\u00f2a tan kh\u00f4ng \u0111\u01b0\u1ee3c ch\u1ee9a d\u1ecb v\u1eadt c\u00f3 th\u1ec3 quan s\u00e1t \u0111\u01b0\u1ee3c b\u1eb1ng m\u1eaft th\u01b0\u1eddng.<\/p>\n<p><em>C\u00e1ch ti\u00eam<\/em><\/p>\n<p>Ceftazidim c\u00f3 th\u1ec3 ti\u00eam t\u0129nh m\u1ea1ch ch\u1eadm trong v\u00f2ng v\u00e0i ph\u00fat ho\u1eb7c ti\u00eam b\u1eafp s\u00e2u v\u00e0o c\u00e1c c\u01a1 l\u1edbn nh\u01b0 c\u01a1 m\u00f4ng, \u0111\u00f9i.<\/p>\n<p>C\u00e1ch pha dung d\u1ecbch ti\u00eam truy\u1ec1n t\u0129nh m\u1ea1ch: 1g thu\u1ed1c pha trong 50-100 ml m\u1ed9t trong c\u00e1c dung d\u1ecbch d\u01b0\u1edbi \u0111\u00e2y \u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c n\u1ed3ng \u0111\u1ed9 10-20 mg\/ml.<\/p>\n<p>Dung d\u1ecbch NaCl 0,9%<\/p>\n<p>N\u01b0\u1edbc c\u1ea5t ti\u00eam.<\/p>\n<p>Dung d\u1ecbch Dextrose 5%<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p><em>Li\u1ec1u d\u00f9ng cho b\u1ec7nh nh\u00e2n c\u00f3 ch\u1ee9c n\u0103ng th\u1eadn b\u00ecnh th\u01b0\u1eddng: <\/em><\/p>\n<p>Li\u1ec1u l\u01b0\u1ee3ng ch\u00ednh x\u00e1c v\u00e0 \u0111\u01b0\u1eddng d\u00f9ng ph\u1ee5 thu\u1ed9c \u0111\u1ed9 tu\u1ed5i, t\u00ecnh tr\u1ea1ng b\u1ec7nh nh\u00e2n, m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng c\u1ee7a nhi\u1ec5m khu\u1ea9n, v\u00e0 t\u00ednh nh\u1ea1y c\u1ea3m c\u1ee7a c\u00e1c sinh v\u1eadt g\u00e2y b\u1ec7nh.<\/p>\n<p><em>Ng\u01b0\u1eddi l\u1edbn<\/em>: C\u00f3 th\u1ec3 d\u00f9ng t\u1eeb 1-6 g\/ng\u00e0y, m\u1ed7i l\u1ea7n c\u00e1ch nhau 8-12h. Trong ph\u1ea7n l\u1edbn c\u00e1c b\u1ec7nh nhi\u1ec5m khu\u1ea9n, li\u1ec1u 1g m\u1ed7i 8h ho\u1eb7c 2g m\u1ed7i 12h \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o. Trong c\u00e1c b\u1ec7nh nhi\u1ec5m khu\u1ea9n ti\u1ebft ni\u1ec7u ho\u1eb7c nhi\u1ec5m khu\u1ea9n \u00edt nghi\u00eam tr\u1ecdng, li\u1ec1u 500mg-1g m\u1ed7i 12h. Tr\u01b0\u1eddng h\u1ee3p nhi\u1ec5m khu\u1ea9n n\u1eb7ng ho\u1eb7c c\u00f3 k\u00e8m suy gi\u1ea3m mi\u1ec5n d\u1ecbch, n\u00ean d\u00f9ng li\u1ec1u 2g m\u1ed7i 8h ho\u1eb7c li\u1ec1u 3g m\u1ed7i 12h.<\/p>\n<p>Trong d\u1ef1 ph\u00f2ng ph\u1eabu thu\u1eadt tuy\u1ebfn ti\u1ec1n li\u1ec7t, ti\u00eam li\u1ec1u 1g t\u1ea1i th\u1eddi \u0111i\u1ec3m g\u00e2y m\u00ea. Li\u1ec1u th\u1ee9 2 \u0111\u01b0\u1ee3c xem x\u00e9t \u1edf giai \u0111o\u1ea1n b\u1ecf \u1ed1ng th\u00f4ng.<\/p>\n<p><em>Ng\u01b0\u1eddi cao tu\u1ed5i:<\/em> \u0110\u00e2y l\u00e0 \u0111\u1ed9 tu\u1ed5i suy gi\u1ea3m ch\u1ee9c n\u0103ng thanh th\u1ea3i thu\u1ed1c, do \u0111\u00f3 kh\u00f4ng v\u01b0\u1ee3t qu\u00e1 3g\/ 24h.<\/p>\n<p><em>B\u1ec7nh nh\u00e2n x\u01a1 nang:<\/em> Vi\u00eam ph\u1ed5i n\u1eb7ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh li\u1ec1u cao t\u1eeb 100-150mg\/kg\/24h, chia l\u00e0m 3 l\u1ea7n m\u1ed7i ng\u00e0y. Li\u1ec1u t\u1ed1i \u0111a: 9g\/ ng\u00e0y.<\/p>\n<p>Tr\u1ebb tr\u00ean 2 th\u00e1ng tu\u1ed5i li\u1ec1u t\u1eeb 30-100mg\/kg\/24h, chia l\u00e0m 2 ho\u1eb7c 3 l\u1ea7n \u0111\u01b0a thu\u1ed1c. Li\u1ec1u 150mg\/kg\/24h (t\u1ed1i \u0111a 6g\/24h) c\u00f3 th\u1ec3 \u0111\u01b0a cho tr\u1ebb trong tr\u01b0\u1eddng h\u1ee3p suy gi\u1ea3m mi\u1ec5n d\u1ecbch ho\u1eb7c vi\u00eam m\u00e0ng n\u00e3o.<\/p>\n<p><em>Li\u1ec1u d\u00f9ng cho b\u1ec7nh nh\u00e2n suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn:<\/em><\/p>\n<p>Ceftazidim h\u1ea7u nh\u01b0 th\u1ea3i tr\u1eeb qua th\u1eadn n\u00ean c\u1ea7n thi\u1ebft ph\u1ea3i gi\u1ea3m li\u1ec1u khi \u0111\u1ed9 thanh th\u1ea3i creatinin gi\u1ea3m d\u01b0\u1edbi 50ml\/ph\u00fat. \u1ede ng\u01b0\u1eddi l\u1edbn suy th\u1eadn, li\u1ec1u ban \u0111\u1ea7u l\u00e0 1g v\u00e0 sau \u0111\u00f3 d\u00f9ng li\u1ec1u duy tr\u00ec th\u00edch h\u1ee3p nh\u01b0 b\u1ea3ng d\u01b0\u1edbi \u0111\u00e2y:<\/p>\n<table>\n<tbody>\n<tr>\n<td><strong>\u0110\u1ed9 thanh th\u1ea3i (ml\/ ph\u00fat)<\/strong><\/td>\n<td><strong>Creatinin huy\u1ebft t\u01b0\u01a1ng (micromol\/l\u00edt)<\/strong><\/td>\n<td><strong>Li\u1ec1u duy tr\u00ec<\/strong><\/td>\n<\/tr>\n<tr>\n<td>50 &#8211; 31<\/td>\n<td>150 &#8211; 200<\/td>\n<td>1 g c\u00e1ch 12 gi\u1edd 1 l\u1ea7n<\/td>\n<\/tr>\n<tr>\n<td>30 &#8211; 16<\/td>\n<td>200 &#8211; 350<\/td>\n<td>1 g c\u00e1ch 24 gi\u1edd 1 l\u1ea7n<\/td>\n<\/tr>\n<tr>\n<td>15 &#8211; 6<\/td>\n<td>350 &#8211; 500<\/td>\n<td>0,5 g c\u00e1ch 24 gi\u1edd 1 l\u1ea7n<\/td>\n<\/tr>\n<tr>\n<td>&lt; 5<\/td>\n<td>&gt; 500<\/td>\n<td>0,5 g c\u00e1ch 48 gi\u1edd 1 l\u1ea7n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u0110\u1ed1i v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n suy th\u1eadn v\u00e0 nhi\u1ec5m khu\u1ea9n n\u1eb7ng, li\u1ec1u d\u00f9ng c\u00f3 th\u1ec3 t\u0103ng th\u00eam 50% so v\u1edbi b\u1ea3ng tr\u00ean, tuy nhi\u00ean khuy\u1ebfn c\u00e1o n\u1ed3ng \u0111\u1ed9 \u0111\u00e1y c\u1ee7a ceftazidim (Ctrough) kh\u00f4ng n\u00ean v\u01b0\u1ee3t qu\u00e1 40mg\/l\u00edt.<\/p>\n<p>Tr\u1ebb em suy th\u1eadn, \u0111\u1ed9 thanh th\u1ea3i creatinin n\u00ean \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ec9nh theo c\u1ea3 di\u1ec7n t\u00edch b\u1ec1 m\u1eb7t c\u01a1 th\u1ec3 ho\u1eb7c kh\u1ed1i l\u01b0\u1ee3ng c\u01a1 \u0111\u1ec3 t\u1eeb \u0111\u00f3 gi\u1ea3m li\u1ec1u so v\u1edbi ng\u01b0\u1eddi l\u1edbn.<\/p>\n<p>\u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n ch\u1ea1y th\u1eadn nh\u00e2n t\u1ea1o: Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a ceftazidim trong ph\u1ea1m vi ch\u1ea1y th\u1eadn nh\u00e2n t\u1ea1o t\u1eeb 3-5h, do \u0111\u00f3 li\u1ec1u duy tr\u00ec th\u00edch h\u1ee3p c\u1ea7n \u0111\u01b0\u1ee3c l\u1eb7p l\u1ea1i theo t\u1eebng chu k\u1ef3 ch\u1ea1y th\u1eadn.<\/p>\n<p>\u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n th\u1ea9m ph\u00e2n ph\u00fac m\u1ea1c: Li\u1ec1u ban \u0111\u1ea7u c\u00f3 th\u1ec3 l\u00e0 1g, ti\u1ebfp theo l\u00e0 500mg m\u1ed7i 24h. Ngo\u00e0i ra n\u1ebfu c\u00f3 nhi\u1ec5m tr\u00f9ng ph\u00fac m\u1ea1c ceftazidim c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c k\u1ebft h\u1ee3p v\u00e0o d\u1ecbch l\u1ecdc m\u00e1u (125-250 mg cho 2 l\u00edt d\u1ecbch l\u1ecdc).<\/p>\n<p><em>Li\u1ec1u d\u00f9ng cho b\u1ec7nh nh\u00e2n suy gan:<\/em><\/p>\n<p>Kh\u00f4ng c\u1ea7n ch\u1ec9nh li\u1ec1u n\u1ebfu kh\u00f4ng c\u00f3 suy th\u1eadn \u0111i k\u00e8m.<\/p>\n<p><strong>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>Ceftazidim ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh v\u1edbi c\u00e1c tr\u01b0\u1eddng h\u1ee3p m\u1eabn c\u1ea3m v\u1edbi ceftazidim ho\u1eb7c c\u00f3 ti\u1ec1n s\u1eed d\u1ecb \u1ee9ng v\u1edbi nh\u00f3m kh\u00e1ng sinh penicilin v\u00e0 cephalosporin.<\/p>\n<p>Ceftazidim khi pha v\u1edbi lidocain kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p:<\/p>\n<p>\u0110\u01b0\u1eddng t\u0129nh m\u1ea1ch.<\/p>\n<p>Tr\u1ebb d\u01b0\u1edbi 30 th\u00e1ng tu\u1ed5i.<\/p>\n<p>B\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed m\u1eabn c\u1ea3m v\u1edbi h\u1ed7n h\u1ee3p n\u00e0y.<\/p>\n<p>B\u1ec7nh nh\u00e2n suy tim n\u1eb7ng<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>4.4 Th\u1eadn tr\u1ecdng:<\/strong><\/p>\n<p>Nh\u01b0 c\u00e1c kh\u00e1ng sinh betalactam kh\u00e1c, tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng cho b\u1ec7nh nh\u00e2n c\u1ea7n ki\u1ec3m tra ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn v\u1edbi thu\u1ed1c, n\u1ebfu c\u00f3 ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng x\u1ea3y ra c\u1ea7n ng\u1eebng thu\u1ed1c.<\/p>\n<p>V\u00ec ceftazidim c\u00f3 ph\u1ed5 kh\u00e1ng khu\u1ea9n r\u1ea5t r\u1ed9ng n\u00ean c\u1ea7n l\u01b0u \u00fd ti\u1ec1n s\u1eed b\u1ec7nh \u0111\u01b0\u1eddng ti\u00eau h\u00f3a, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u0111\u1ea1i tr\u00e0ng.<\/p>\n<p>Vi\u1ec7c s\u1eed d\u1ee5ng k\u00e9o d\u00e0i ceftazidim c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n qu\u00e1 m\u1ee9c c\u1ee7a c\u00e1c ch\u1ee7ng kh\u00f4ng nh\u1ea1y c\u1ea3m nh\u01b0 Candida spp., Enterococci do \u0111\u00f3 c\u00f3 th\u1ec3 ph\u1ea3i gi\u00e1n \u0111o\u1ea1n \u0111i\u1ec1u tr\u1ecb ho\u1eb7c c\u00f3 bi\u1ec7n ph\u00e1p th\u00edch h\u1ee3p kh\u1eafc ph\u1ee5c.<\/p>\n<p>L\u01b0u \u00fd v\u1ec1 tr\u01b0\u1eddng h\u1ee3p suy th\u1eadn, \u0111\u1eb7c bi\u1ec7t l\u00e0 nh\u1eefng b\u1ec7nh nh\u00e2n d\u00f9ng li\u1ec1u cao.<\/p>\n<p>Ceftazidim c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m th\u1eddi gian prothrombin. C\u1ea7n theo d\u00f5i th\u1eddi gian prothrombin \u1edf ng\u01b0\u1eddi suy th\u1eadn, gan, suy dinh d\u01b0\u1ee1ng v\u00e0 n\u1ebfu c\u1ea7n ph\u1ea3i cho vitamin K. N\u00ean gi\u1ea3m li\u1ec1u h\u00e0ng ng\u00e0y khi d\u00f9ng cho ng\u01b0\u1eddi b\u1ec7nh suy th\u1eadn.<\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>Ch\u00f3ng m\u1eb7t c\u00f3 th\u1ec3 x\u1ea3y ra khi s\u1eed d\u1ee5ng thu\u1ed1c, do \u0111\u00f3 th\u1eadn tr\u1ecdng khi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c<\/p>\n<p><strong>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/strong><\/p>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: B1<\/p>\n<p>US FDA pregnancy category: B<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>Ch\u01b0a c\u00f3 b\u00e1o c\u00e1o v\u1ec1 kh\u1ea3 n\u0103ng g\u00e2y qu\u00e1i thai c\u1ee7a ceftazidim nh\u01b0ng c\u0169ng ch\u01b0a c\u00f3 \u0111\u1ee7 nghi\u00ean c\u1ee9u v\u1ec1 t\u00ednh an to\u00e0n c\u1ee7a ceftazidim khi d\u00f9ng cho ph\u1ee5 n\u1eef c\u00f3 thai, do \u0111\u00f3 c\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng cho ph\u1ee5 n\u1eef c\u00f3 thai, \u0111\u1eb7c bi\u1ec7t trong nh\u1eefng th\u00e1ng \u0111\u1ea7u thai k\u1ef3. Tham kh\u1ea3o \u00fd ki\u1ebfn b\u00e1c s\u1ef9 v\u00e0 c\u00e2n nh\u1eafc l\u1ee3i \u00edch nguy c\u01a1 tr\u01b0\u1edbc khi d\u00f9ng.<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>Ceftazidim th\u1ea3i tr\u1eeb qua s\u1eefa m\u1eb9 \u1edf n\u1ed3ng \u0111\u1ed9 th\u1ea5p. Th\u1eadn tr\u1ecdng khi d\u00f9ng cho ph\u1ee5 n\u1eef cho con b\u00fa.<\/p>\n<p><strong>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/strong><\/p>\n<p><em>C\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n th\u01b0\u1eddng g\u1eb7p:<\/em><\/p>\n<p><em>M\u1eabn c\u1ea3m:<\/em> Ph\u00e1t ban, ng\u1ee9a, s\u1ed1t.<\/p>\n<p><em>Gan<\/em>: T\u0103ng t\u1ea1m th\u1eddi AST (SGOT), ALT (SGPT), v\u00e0 phosphatase ki\u1ec1m.<\/p>\n<p><em>T\u1ea1i ch\u1ed7 ti\u00eam<\/em>: n\u00f3ng, \u0111\u1ecf, vi\u00eam khi ti\u00eam t\u0129nh m\u1ea1ch, \u0111au, chai c\u1ee9ng,<\/p>\n<p><em>C\u00e1c t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n \u00edt th\u01b0\u1eddng xuy\u00ean h\u01a1n:<\/em><\/p>\n<p><em>M\u1eabn c\u1ea3m:<\/em> T\u00ea v\u00e0 s\u1ed1c ph\u1ea3n v\u1ec7<\/p>\n<p><em>Th\u1eadn<\/em>: t\u0103ng t\u1ea1m th\u1eddi ure v\u00e0 creatinin<\/p>\n<p><em>Huy\u1ebft h\u1ecdc<\/em>: Thi\u1ebfu m\u00e1u, bao g\u1ed3m thi\u1ebfu m\u00e1u t\u00e1n huy\u1ebft, t\u0103ng b\u1ea1ch c\u1ea7u \u01b0a acid, gi\u1ea3m t\u1ed5ng b\u1ea1ch c\u1ea7u, gi\u1ea3m ti\u1ec3u c\u1ea7u<\/p>\n<p><em>Ti\u1ebft ni\u1ec7u sinh d\u1ee5c<\/em>: Vi\u00eam \u00e2m \u0111\u1ea1o, nhi\u1ec5m n\u1ea5m Candida \u00e2m \u0111\u1ea1o.<\/p>\n<p><em>\u0110\u01b0\u1eddng ti\u00eau h\u00f3a<\/em>: Ti\u00eau ch\u1ea3y, bu\u1ed3n n\u00f4n v\u00e0 \u00f3i m\u1eeda.<\/p>\n<p><em>T\u00e2m th\u1ea7n<\/em>: B\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 c\u00f3 l\u1eabn l\u1ed9n t\u1ea1m th\u1eddi.<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<p><strong>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/strong><\/p>\n<p>Ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c. V\u1edbi c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i nh\u1eb9, th\u01b0\u1eddng ch\u1ec9 c\u1ea7n ng\u1eebng thu\u1ed1c. Tr\u01b0\u1eddng h\u1ee3p m\u1eabn c\u1ea3m n\u1eb7ng ho\u1eb7c ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, c\u1ea7n ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 (gi\u1eef tho\u00e1ng kh\u00ed v\u00e0 d\u00f9ng epinephrin, th\u1edf oxygen, d\u00f9ng kh\u00e1ng histamin, corticoid&#8230;).<\/p>\n<p><strong>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/strong><\/p>\n<p>Thu\u1ed1c kh\u00e1ng sinh aminoglycosid v\u00e0 thu\u1ed1c l\u1ee3i ti\u1ec3u: \u0110\u1ed9c t\u00ednh tr\u00ean th\u1eadn \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o khi d\u00f9ng \u0111\u1ed3ng th\u1eddi cephalosporin v\u00e0 c\u00e1c thu\u1ed1c kh\u00e1ng sinh aminoglycosid ho\u1eb7c c\u00e1c thu\u1ed1c l\u1ee3i ti\u1ec3u m\u1ea1nh, ch\u1eb3ng h\u1ea1n nh\u01b0 furosemid. Ch\u1ee9c n\u0103ng th\u1eadn n\u00ean \u0111\u01b0\u1ee3c theo d\u00f5i c\u1ea9n th\u1eadn, \u0111\u1eb7c bi\u1ec7t l\u00e0 n\u1ebfu d\u00f9ng li\u1ec1u cao aminoglycosid ho\u1eb7c n\u1ebfu \u0111i\u1ec1u tr\u1ecb k\u00e9o d\u00e0i, v\u00ec \u0111\u1ed9c t\u00ednh cao tr\u00ean th\u1eadn c\u1ee7a thu\u1ed1c kh\u00e1ng sinh aminoglycosid.<\/p>\n<p>Kh\u00e1ng sinh kh\u00e1c: In vitro, chloramphenicol \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 \u0111\u1ed1i kh\u00e1ng v\u1edbi ceftazidim v\u00e0 c\u00e1c cephalosporin kh\u00e1c. M\u1ed1i li\u00ean quan l\u00e2m s\u00e0ng c\u1ee7a ph\u00e1t hi\u1ec7n n\u00e0y ch\u01b0a r\u00f5 r\u00e0ng, nh\u01b0ng n\u1ebfu \u0111\u1ed3ng th\u1eddi d\u00f9ng ceftazidim v\u1edbi chloramphenicol, kh\u1ea3 n\u0103ng c\u1ee7a \u0111\u1ed1i kh\u00e1ng c\u1ea7n \u0111\u01b0\u1ee3c xem x\u00e9t.<\/p>\n<p>\u1ea2nh h\u01b0\u1edfng t\u1edbi c\u00e1c th\u1eed nghi\u1ec7m ph\u00f2ng th\u00ed nghi\u1ec7m:<\/p>\n<p>Ceftazidim kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn k\u1ebft qu\u1ea3 \u0111o \u0111\u01b0\u1eddng ni\u1ec7u b\u1eb1ng x\u00e9t nghi\u1ec7m enzym. \u1ea2nh h\u01b0\u1edfng tr\u00ean th\u1eed nghi\u1ec7m v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p gi\u1ea3m \u0111\u1ed3ng (Benedict, Fehling, Clinitest) c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y.<\/p>\n<p>Ceftazidim kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn c\u00e1c x\u00e9t nghi\u1ec7m picrat ki\u1ec1m \u0111\u1ecbnh l\u01b0\u1ee3ng creatinin.<\/p>\n<p>Th\u1eed nghi\u1ec7m Coombs d\u01b0\u01a1ng t\u00ednh gi\u1ea3 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c nh\u00ecn th\u1ea5y trong khi \u0111i\u1ec1u tr\u1ecb v\u1edbi cephalosporin.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/strong><\/p>\n<p>Tri\u1ec7u ch\u1ee9ng qu\u00e1 li\u1ec1u c\u00f3 th\u1ec3 nghi ng\u1edd khi vi\u00eam, \u0111au v\u00e0 vi\u00eam t\u0129nh m\u1ea1ch t\u1ea1i ch\u1ed7 ti\u00eam.<\/p>\n<p>Qu\u00e1 li\u1ec1u ho\u1eb7c d\u00f9ng li\u1ec1u l\u01b0\u1ee3ng l\u1edbn khi b\u1ec7nh nh\u00e2n c\u00f3 suy th\u1eadn c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn di ch\u1ee9ng th\u1ea7n kinh bao g\u1ed3m ch\u00f3ng m\u1eb7t, r\u1ed1i lo\u1ea1n c\u1ea3m x\u00fac, nh\u1ee9c \u0111\u1ea7u, co gi\u1eadt, b\u1ec7nh n\u00e3o v\u00e0 h\u00f4n m\u00ea.<\/p>\n<p>X\u00e9t nghi\u1ec7m b\u1ea5t th\u01b0\u1eddng c\u00f3 th\u1ec3 x\u1ea3y ra sau khi qu\u00e1 li\u1ec1u bao g\u1ed3m n\u1ed3ng \u0111\u1ed9 cao creatinin, t\u0103ng men gan v\u00e0 bilirubin, th\u1eed nghi\u1ec7m Coombs d\u01b0\u01a1ng t\u00ednh, t\u0103ng ti\u1ec3u c\u1ea7u, gi\u1ea3m ti\u1ec3u c\u1ea7u, t\u0103ng b\u1ea1ch c\u1ea7u \u00e1i toan, gi\u1ea3m b\u1ea1ch c\u1ea7u v\u00e0 k\u00e9o d\u00e0i th\u1eddi gian prothrombin.<\/p>\n<p>C\u00e1c bi\u1ec7n ph\u00e1p chung \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng v\u00e0 h\u1ed7 tr\u1ee3 n\u00ean \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n, c\u00f9ng v\u1edbi c\u00e1c bi\u1ec7n ph\u00e1p c\u1ee5 th\u1ec3 \u0111\u1ec3 ki\u1ec3m so\u00e1t b\u1ea5t k\u1ef3 c\u01a1n co gi\u1eadt. Trong tr\u01b0\u1eddng h\u1ee3p qu\u00e1 li\u1ec1u tr\u1ea7m tr\u1ecdng, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u1edf m\u1ed9t b\u1ec7nh nh\u00e2n b\u1ecb suy th\u1eadn, ch\u1ea1y th\u1eadn nh\u00e2n t\u1ea1o k\u1ebft h\u1ee3p v\u00e0 l\u1ecdc m\u00e1u c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c xem x\u00e9t.<\/p>\n<p><strong>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/strong><\/p>\n<p><strong>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/strong><\/p>\n<p>Ceftazidim c\u00f3 t\u00e1c d\u1ee5ng di\u1ec7t khu\u1ea9n do \u1ee9c ch\u1ebf c\u00e1c enzym t\u1ed5ng h\u1ee3p v\u00e1ch t\u1ebf b\u00e0o vi khu\u1ea9n. Thu\u1ed1c b\u1ec1n v\u1eefng v\u1edbi h\u1ea7u h\u1ebft c\u00e1c beta &#8211; lactamase c\u1ee7a vi khu\u1ea9n tr\u1eeb enzym c\u1ee7a Bacteroides. Thu\u1ed1c nh\u1ea1y c\u1ea3m v\u1edbi nhi\u1ec1u vi khu\u1ea9n Gram \u00e2m \u0111\u00e3 kh\u00e1ng aminoglycosid v\u00e0 c\u00e1c vi khu\u1ea9n Gram d\u01b0\u01a1ng \u0111\u00e3 kh\u00e1ng ampicilin v\u00e0 c\u00e1c cephalosporin kh\u00e1c.<\/p>\n<p><em>Ph\u1ed5 kh\u00e1ng khu\u1ea9n: <\/em><\/p>\n<p>T\u00e1c d\u1ee5ng t\u1ed1t: Vi khu\u1ea9n Gram \u00e2m \u01b0a kh\u00ed bao g\u1ed3m Pseudomonas (P. aeruginosa), E. coli, Proteus (c\u1ea3 d\u00f2ng indol d\u01b0\u01a1ng t\u00ednh v\u00e0 \u00e2m t\u00ednh), Klebsiella, Enterobacter, Acinetobacter, Citrobacter, Serratia, Salmonella, Shigella, Hemophilus influenzae, Neisseria gonorrhoea v\u00e0 Neisseria meningitidis. M\u1ed9t s\u1ed1 ch\u1ee7ng Pneumococcus, Moraxella catarrhalis, v\u00e0 Streptococcus tan m\u00e1u beta, (nh\u00f3m A, B, C v\u00e0 G lancefield) v\u00e0 Streptococcus viridans. Nhi\u1ec1u ch\u1ee7ng Gram d\u01b0\u01a1ng k\u1ef5 kh\u00ed c\u0169ng nh\u1ea1y c\u1ea3m, Staphylococcus aureus nh\u1ea1y c\u1ea3m v\u1eeba ph\u1ea3i v\u1edbi ceftazidim.<\/p>\n<p><em>Kh\u00e1ng thu\u1ed1c:<\/em><\/p>\n<p>Kh\u00e1ng thu\u1ed1c c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb do m\u1ea5t t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf c\u00e1c beta &#8211; lactamase qua trung gian nhi\u1ec5m s\u1eafc th\u1ec3 (\u0111\u1eb7c bi\u1ec7t \u0111\u1ed1i v\u1edbi Pseudomonas spp., Enterobacter v\u00e0 Klebsiella).<\/p>\n<p>Ceftazidim kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng v\u1edbi Staphylococcus aureus kh\u00e1ng methicilin, Enterococcus, Listeria monocytogenes, Bacteriodes fragilis, Campylobacter spp., Clostridium difficile.<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>Ceftazidim l\u00e0 m\u1ed9t kh\u00e1ng sinh cephalosporin th\u1ebf h\u1ec7 3 c\u00f3 t\u00e1c d\u1ee5ng di\u1ec7t khu\u1ea5n do \u1ee9c ch\u1ebf c\u00e1c enzym t\u1ed5ng h\u1ee3p th\u00e0nh t\u1ebf b\u00e0o vi khu\u1ea5n.<\/p>\n<p><a href=\"https:\/\/www.youtube.com\/watch?v=0TIIfoiJFwA\"><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/a><\/p>\n<p><strong>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/strong><\/p>\n<p><em>H\u1ea5p thu<\/em><\/p>\n<p>N\u1ed3ng \u0111\u1ed9 t\u1ed1i \u0111a Cmax t\u01b0\u01a1ng \u1ee9ng sau khi \u0111\u01b0a c\u00e1c li\u1ec1u kh\u00e1c nhau c\u1ee7a ceftazidim nh\u01b0 sau:<\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"4\"><em>B\u1ea3ng 1. N\u1ed3ng \u0111\u1ed9 \u0111\u1ec9nh trung b\u00ecnh c\u1ee7a thu\u1ed1c trong huy\u1ebft thanh \u1edf ng\u01b0\u1eddi l\u1edbn kh\u1ecfe m\u1ea1nh<\/em><\/td>\n<\/tr>\n<tr>\n<td><strong>L\u01b0\u1ee3ng thu\u1ed1c<\/strong><\/td>\n<td><strong>Ti\u00eam b\u1eafp (sau 1 gi\u1edd)<\/strong><\/td>\n<td><strong>Ti\u00eam t\u0129nh m\u1ea1ch (sau 5 ph\u00fat)<\/strong><\/td>\n<td><strong>Ti\u00eam truy\u1ec1n t\u0129nh m\u1ea1ch kh\u00f4ng li\u00ean t\u1ee5c (sau 20 &#8211; 30 ph\u00fat)<\/strong><\/td>\n<\/tr>\n<tr>\n<td>0,5g<\/td>\n<td>18mg\/l<\/td>\n<td>45mg\/l<\/td>\n<td>40mg\/l<\/td>\n<\/tr>\n<tr>\n<td>1g<\/td>\n<td>39mg\/l<\/td>\n<td>90mg\/l<\/td>\n<td>70mg\/l<\/td>\n<\/tr>\n<tr>\n<td>2g<\/td>\n<td><\/td>\n<td>170mg\/l<\/td>\n<td>170mg\/l<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>N\u00f3i chung, n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng 8 gi\u1edd sau khi ti\u00eam t\u0129nh m\u1ea1ch ho\u1eb7c ti\u00eam b\u1eafp li\u1ec1u 500 mg ho\u1eb7c h\u01a1n ceftazidim v\u01b0\u1ee3t qu\u00e1 2 mg\/l. Sau c\u00e1c li\u1ec1u ti\u00eam t\u0129nh m\u1ea1ch 1 g v\u00e0 2g m\u1ed7i 8 gi\u1edd trong 10 ng\u00e0y, kh\u00f4ng c\u00f3 b\u1eb1ng ch\u1ee9ng t\u00edch l\u0169y c\u1ee7a ceftazidim trong huy\u1ebft thanh c\u1ee7a c\u00e1c b\u1ec7nh nh\u00e2n c\u00f3 ch\u1ee9c n\u0103ng th\u1eadn b\u00ecnh th\u01b0\u1eddng.<\/p>\n<p><em>Ph\u00e2n b\u1ed1:<\/em><\/p>\n<p>D\u01b0\u1edbi 10% ceftazidim li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng v\u00e0 m\u1ee9c \u0111\u1ed9 li\u00ean k\u1ebft \u0111\u1ed9c l\u1eadp v\u1edbi n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u. N\u1ed3ng \u0111\u1ed9 ceftazidim v\u01b0\u1ee3t qu\u00e1 n\u1ed3ng \u0111\u1ed9 \u1ee9c ch\u1ebf t\u1ed1i thi\u1ec3u trong h\u1ea7u h\u1ebft c\u00e1c m\u00f4 nh\u01b0 x\u01b0\u01a1ng, tim, m\u1eadt, \u0111\u1eddm, th\u1ee7y d\u1ecbch, d\u1ecbch m\u00e0ng ph\u1ed5i v\u00e0 d\u1ecbch m\u00e0ng b\u1ee5ng. Ceftazidim \u0111i qua h\u00e0ng r\u00e0o m\u00e1u n\u00e3o v\u1edbi n\u1ed3ng \u0111\u1ed9 th\u1ea5p, n\u1ed3ng \u0111\u1ed9 \u0111i\u1ec1u tr\u1ecb kho\u1ea3ng 4-20mg\/l nh\u01b0ng \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 cao h\u01a1n khi m\u00e0ng n\u00e3o b\u1ecb vi\u00eam.<\/p>\n<p><em>Th\u1ea3i tr\u1eeb:<\/em><\/p>\n<p>Kho\u1ea3ng 80-90% li\u1ec1u c\u1ee7a ceftazidim \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i qua th\u1eadn \u1edf d\u1ea1ng kh\u00f4ng \u0111\u1ed5i trong 24h, d\u1eabn \u0111\u1ebfn n\u1ed3ng \u0111\u1ed9 thu\u1ed1c cao trong n\u01b0\u1edbc ti\u1ec3u.<\/p>\n<p>V\u1edbi c\u00e1c b\u1ec7nh nh\u00e2n c\u00f3 ch\u1ee9c n\u0103ng th\u1eadn b\u00ecnh th\u01b0\u1eddng, th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a ceftazidim l\u00e0 2h sau khi ti\u00eam t\u0129nh m\u1ea1ch ho\u1eb7c ti\u00eam b\u1eafp.<\/p>\n<p><strong>5.3 Gi\u1ea3i th\u00edch: <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong>5.4 Thay th\u1ebf thu\u1ed1c : <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/strong><\/p>\n<p><strong>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/strong><\/p>\n<p>Kh\u00f4ng c\u00f3<\/p>\n<p><strong>6.2. T\u01b0\u01a1ng k\u1ef5 :<\/strong><\/p>\n<p>V\u1edbi dung d\u1ecbch natri bicarbonat: L\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng thu\u1ed1c. Kh\u00f4ng pha ceftazidim v\u00e0o dung d\u1ecbch c\u00f3 pH tr\u00ean 7,5 (kh\u00f4ng \u0111\u01b0\u1ee3c pha thu\u1ed1c v\u00e0o dung d\u1ecbch natri bicarbonat).<\/p>\n<p>Ph\u1ed1i h\u1ee3p v\u1edbi vancomycin ph\u1ea3i d\u00f9ng ri\u00eang v\u00ec g\u00e2y k\u1ebft t\u1ee7a.<\/p>\n<p>Kh\u00f4ng pha l\u1eabn ceftazidim v\u1edbi c\u00e1c aminoglycosid (gentamicin, streptomycin), ho\u1eb7c metronidazol.<\/p>\n<p>Ph\u1ea3i tr\u00e1ng r\u1eeda c\u1ea9n th\u1eadn c\u00e1c \u1ed1ng th\u00f4ng v\u00e0 b\u01a1m ti\u00eam b\u1eb1ng n\u01b0\u1edbc mu\u1ed1i (natri clorid 0,9%) gi\u1eefa c\u00e1c l\u1ea7n d\u00f9ng hai lo\u1ea1i thu\u1ed1c n\u00e0y, \u0111\u1ec3 tr\u00e1nh g\u00e2y k\u1ebft t\u1ee7a.<\/p>\n<p><strong>6.3. B\u1ea3o qu\u1ea3n: <\/strong><\/p>\n<p>\u0110\u1ec3 n\u01a1i kh\u00f4, nhi\u1ec7t \u0111\u1ed9 kh\u00f4ng qu\u00e1 30\u00b0C, tr\u00e1nh \u00e1nh s\u00e1ng.<\/p>\n<p><strong>6.4. Th\u00f4ng tin kh\u00e1c :<\/strong><\/p>\n<p>Kh\u00f4ng c\u00f3.<\/p>\n<p><strong>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/strong><\/p>\n<p>D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Ceftazidime Ph\u00e2n lo\u1ea1i: Thu\u1ed1c Kh\u00e1ng sinh nh\u00f3m cephalosporin th\u1ebf h\u1ec7 3. Nh\u00f3m ph\u00e1p l\u00fd: Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine) M\u00e3 ATC (Anatomical Therapeutic Chemical): J01DD02. Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c: FORTUM Bi\u1ec7t d\u01b0\u1ee3c: Hwazim Inj, Hudizim Inj, Domrid Inj H\u00e3ng [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":18366,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[621],"class_list":["post-18365","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-ceftazidime"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/18365","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=18365"}],"version-history":[{"count":3,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/18365\/revisions"}],"predecessor-version":[{"id":50297,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/18365\/revisions\/50297"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/18366"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=18365"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=18365"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=18365"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}