{"id":14632,"date":"2019-08-21T08:29:40","date_gmt":"2019-08-21T01:29:40","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=14632"},"modified":"2025-01-09T08:31:24","modified_gmt":"2025-01-09T01:31:24","slug":"zopiclone-phamzopic","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/zopiclone-phamzopic\/","title":{"rendered":"Zopiclone &#8211; Phamzopic"},"content":{"rendered":"<p><strong>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: <\/strong><\/p>\n<p><strong><em>Ho\u1ea1t ch\u1ea5t :<\/em> <a href=\"https:\/\/pharmog.com\/wp\/zopiclone\/\">Zopiclone<\/a><\/strong><\/p>\n<p><strong><em>Ph\u00e2n lo\u1ea1i: <\/em><\/strong><em>Thu\u00f4\u0301c an th\u00e2\u0300n g\u00e2y ngu\u0309.<\/em><\/p>\n<p><strong><em>Nh\u00f3m<\/em><\/strong> <strong><em>ph\u00e1p l\u00fd: <\/em><\/strong><em>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n<p><strong><em>M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): N05CF01.<\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em><\/strong><\/p>\n<p><strong><em>Bi\u1ec7t d\u01b0\u1ee3c:<\/em><\/strong> PHAMZOPIC<\/p>\n<p><strong><em>H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: Pharmascience Inc..<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>2. D\u1ea1ng b\u00e0o ch\u1ebf &#8211; H\u00e0m l\u01b0\u1ee3ng: <\/strong><\/p>\n<p><strong><em>D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n<p>Vi\u00ean n\u00e9n 7,5 mg.<\/p>\n<p>Vi\u00ean n\u00e9n: chai 100 vi\u00ean.<\/p>\n<p><strong><em>Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\"><strong><em>PHAMZOPIC 7.5mg<\/em><\/strong><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><em>M\u1ed7i vi\u00ean n\u00e9n c\u00f3 ch\u1ee9a:<\/em><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Zopiclone<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>7,5 mg<\/td>\n<\/tr>\n<tr>\n<td>T\u00e1 d\u01b0\u1ee3c<\/td>\n<td>&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.<\/td>\n<td>v\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"360\" height=\"529\" class=\"wp-image-14633\" src=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/08\/word-image-324.png\" srcset=\"https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/08\/word-image-324.png 360w, https:\/\/pharmog.com\/wp\/wp-content\/uploads\/2019\/08\/word-image-324-204x300.png 204w\" sizes=\"auto, (max-width: 360px) 100vw, 360px\" \/><\/p>\n<p><strong>3. Video by Pharmog:<\/strong><\/p>\n<p><strong>[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>\u25ba K\u1ecbch B\u1ea3n: PharmogTeam<\/p>\n<p>\u25ba Youtube: https:\/\/www.youtube.com\/c\/pharmog<\/p>\n<p>\u25ba Facebook: https:\/\/www.facebook.com\/pharmog\/<\/p>\n<p>\u25ba Group : H\u1ed9i nh\u1eefng ng\u01b0\u1eddi m\u00ea d\u01b0\u1ee3c l\u00fd<\/p>\n<p>\u25ba Instagram : https:\/\/www.instagram.com\/pharmogvn\/<\/p>\n<p>\u25ba Website: pharmog.com<\/p>\n<p><strong>4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng: <\/strong><\/p>\n<p><strong>4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>R\u1ed1i lo\u1ea1n gi\u1ea5c ng\u1ee7 c\u00f3 nguy\u00ean nh\u00e2n t\u1eeb nh\u1eefng b\u1ea5t th\u01b0\u1eddng v\u1ec1 c\u01a1 th\u1ec3 v\u00e0\/ho\u1eb7c t\u00e2m th\u1ea7n. Do v\u1eady, ch\u1ec9 n\u00ean quy\u1ebft \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng m\u1ea5t ng\u1ee7 cho b\u1ec7nh nh\u00e2n sau khi \u0111\u00e3 \u0111\u00e1nh gi\u00e1 k\u1ef9 l\u01b0\u1ee1ng t\u00ecnh tr\u1ea1ng b\u1ec7nh c\u1ee7a b\u1ec7nh nh\u00e2n.<\/p>\n<p>PHAMZOPIC \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh d\u00f9ng trong th\u1eddi gian ng\u1eafn \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb v\u00e0 gi\u1ea3m tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh m\u1ea5t ng\u1ee7 v\u1edbi c\u00e1c bi\u1ec3u hi\u1ec7n nh\u01b0 kh\u00f3 ng\u1ee7, th\u01b0\u1eddng xuy\u00ean t\u1ec9nh gi\u1ea5c v\u1ec1 \u0111\u00eam v\u00e0\/ho\u1eb7c th\u1ee9c d\u1eady s\u1edbm.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb b\u1eb1ng PHAMZOPIC kh\u00f4ng n\u00ean k\u00e9o d\u00e0i qu\u00e1 7 t\u1edbi 10 ng\u00e0y li\u00ean ti\u1ebfp. Trong tr\u01b0\u1eddng h\u1ee3p \u0111i\u1ec1u tr\u1ecb li\u00ean t\u1ee5c trong 2 t\u1edbi 3 tu\u1ea7n c\u1ea7n ph\u1ea3i ki\u1ec3m tra to\u00e0n di\u1ec7n t\u00ecnh tr\u1ea1ng b\u1ec7nh c\u1ee7a b\u1ec7nh nh\u00e2n. Ch\u1ec9 n\u00ean k\u00ea \u0111\u01a1n d\u00f9ng Zopiclone trong th\u1eddi gian ng\u1eafn (7-10 ng\u00e0y) v\u00e0 kh\u00f4ng n\u00ean k\u00ea qu\u00e1 s\u1ed1 l\u01b0\u1ee3ng d\u00f9ng cho 1 th\u00e1ng.<\/p>\n<p>Vi\u1ec7c d\u00f9ng thu\u1ed1c ng\u1ee7 c\u1ea7n h\u1ea1n ch\u1ebf trong tr\u01b0\u1eddng h\u1ee3p r\u1ed1i lo\u1ea1n gi\u1ea5c ng\u1ee7 g\u00e2y ra do thay \u0111\u1ed5i m\u00fai gi\u1edd.<\/p>\n<p><strong>4.2. Li\u1ec1u d\u00f9ng &#8211; C\u00e1ch d\u00f9ng:<\/strong><\/p>\n<p><strong><em>C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n<p>D\u00f9ng u\u1ed1ng.<\/p>\n<p>N\u00ean d\u00f9ng li\u1ec1u th\u1ea5p nh\u1ea5t c\u00f3 hi\u1ec7u qu\u1ea3 trong m\u1ed7i \u0111\u1ee3t \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p><strong><em>Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n<p>D\u00f9ng PHAMZOPIC kh\u00f4ng n\u00ean k\u00e9o d\u00e0i qu\u00e1 7-10 ng\u00e0y li\u00ean t\u1ee5c. Trong tr\u01b0\u1eddng h\u1ee3p \u0111i\u1ec1u tr\u1ecb li\u00ean t\u1ee5c trong 2 t\u1edbi 3 tu\u1ea7n c\u1ea7n ph\u1ea3i ki\u1ec3m tra to\u00e0n di\u1ec7n t\u00ecnh tr\u1ea1ng b\u1ec7nh c\u1ee7a b\u1ec7nh nh\u00e2n. Thu\u1ed1c n\u00ean u\u1ed1ng ngay tr\u01b0\u1edbc khi \u0111i ng\u1ee7.<\/p>\n<p>Li\u1ec1u d\u00f9ng cho ng\u01b0\u1eddi l\u1edbn: Th\u00f4ng th\u01b0\u1eddng l\u00e0 1 vi\u00ean PHAMZOPIC 7,5mg. Kh\u00f4ng n\u00ean d\u00f9ng qu\u00e1 li\u1ec1u n\u00e0y.<\/p>\n<p>Ng\u01b0\u1eddi gi\u00e0: Li\u1ec1u khuy\u1ebfn c\u00e1o d\u00f9ng cho ng\u01b0\u1eddi l\u1edbn tu\u1ed5i v\u00e0\/ho\u1eb7c b\u1ec7nh nh\u00e2n s\u1ee9c kh\u1ecfe y\u1ebfu l\u00e0 1\/2 vi\u00ean (3,75mg) tr\u01b0\u1edbc khi ng\u1ee7. Li\u1ec1u d\u00f9ng c\u00f3 th\u1ec3 t\u0103ng l\u00ean 1 vi\u00ean trong tr\u01b0\u1eddng h\u1ee3p v\u1edbi li\u1ec1u th\u1ea5p kh\u00f4ng mang l\u1ea1i t\u00e1c d\u1ee5ng mong mu\u1ed1n.<\/p>\n<p>B\u1ec7nh nh\u00e2n b\u1ecb suy gi\u1ea3m ch\u1ee9c n\u0103ng gan ho\u1eb7c b\u1ecb suy h\u00f4 h\u1ea5p m\u00e3n t\u00ednh: Li\u1ec1u khuy\u1ebfn c\u00e1o l\u00e0 3,75mg (1\/2 vi\u00ean) t\u00f9y thu\u1ed9c v\u00e0o m\u1ee9c \u0111\u1ed9 \u0111\u00e1p \u1ee9ng v\u00e0 t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c. C\u00f3 th\u1ec3 d\u00f9ng li\u1ec1u t\u1edbi 7,5mg (1 vi\u00ean) trong tr\u01b0\u1eddng h\u1ee3p c\u1ea7n thi\u1ebft nh\u01b0ng ph\u1ea3i th\u1eadn tr\u1ecdng.<\/p>\n<p>Zopiclone kh\u00f4ng n\u00ean d\u00f9ng cho b\u1ec7nh nh\u00e2n d\u01b0\u1edbi 18 tu\u1ed5i.<\/p>\n<p><strong>4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n<p>B\u1ec7nh nh\u00e2n m\u1eabn c\u1ea3m v\u1edbi thu\u1ed1c hay c\u00e1c th\u00e0nh ph\u1ea7n c\u1ee7a thu\u1ed1c.<\/p>\n<p>B\u1ec7nh nh\u00e2n b\u1ecb suy h\u00f4 h\u1ea5p n\u1eb7ng (nh\u01b0 trong h\u1ed9i ch\u1ee9ng ng\u01b0ng th\u1edf khi ng\u1ee7).<\/p>\n<p>B\u1ec7nh nh\u00e2n t\u1eebng b\u1ecb ph\u1ea3n \u1ee9ng b\u1ea5t th\u01b0\u1eddng v\u1edbi r\u01b0\u1ee3u v\u00e0\/ho\u1eb7c thu\u1ed1c an th\u1ea7n.<\/p>\n<p><strong> 4.4 Th\u1eadn tr\u1ecdng:<\/strong><\/p>\n<p>Thu\u1ed1c n\u00ean \u0111\u01b0\u1ee3c d\u00f9ng th\u1eadn tr\u1ecdng cho b\u1ec7nh nh\u00e2n t\u1eebng b\u1ecb ph\u1ea3n \u1ee9ng b\u1ea5t th\u01b0\u1eddng khi d\u00f9ng r\u01b0\u1ee3u v\u00e0\/ho\u1eb7c thu\u1ed1c an th\u1ea7n.<\/p>\n<p>\u0110\u1ed1i v\u1edbi ng\u01b0\u1eddi cao tu\u1ed5i: Ch\u1ec9 n\u00ean d\u00f9ng thu\u1ed1c cho ng\u01b0\u1eddi cao tu\u1ed5i \u1edf li\u1ec1u th\u1ea5p nh\u1ea5t c\u00f3 t\u00e1c d\u1ee5ng. D\u00f9ng thu\u1ed1c an th\u1ea7n li\u1ec1u cao kh\u00f4ng th\u00edch \u0111\u00e1ng \u1edf ng\u01b0\u1eddi gi\u00e0 c\u00f3 th\u1ec3 g\u00e2y ra h\u1eadu qu\u1ea3 kh\u00f4ng l\u01b0\u1eddng tr\u01b0\u1edbc \u0111\u01b0\u1ee3c.<\/p>\n<p>Vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c an th\u1ea7n kh\u00f4ng c\u00f3 k\u1ebft qu\u1ea3 sau 7-10 ng\u00e0y c\u00f3 th\u1ec3 ngh\u0129 t\u1edbi m\u1ed9t b\u1ec7nh v\u1ec1 t\u00e2m th\u1ea7n v\u00e0\/ho\u1eb7c tr\u1ea1ng th\u00e1i b\u1ec7nh l\u00fd ti\u00ean ph\u00e1t n\u00e0o kh\u00e1c ho\u1eb7c hi\u1ec7n t\u01b0\u1ee3ng m\u1ea5t ph\u1ea3n x\u1ea1 v\u1ec1 gi\u1ea5c ng\u1ee7.<\/p>\n<p>T\u00ecnh tr\u1ea1ng m\u1ea5t ng\u1ee7 t\u0103ng n\u1eb7ng ho\u1eb7c s\u1ef1 xu\u1ea5t hi\u1ec7n nh\u1eefng b\u1ea5t th\u01b0\u1eddng m\u1edbi v\u1ec1 suy ngh\u0129 ho\u1eb7c h\u00e0nh vi c\u00f3 th\u1ec3 l\u00e0 h\u1eadu qu\u1ea3 c\u1ee7a t\u00ecnh tr\u1ea1ng r\u1ed1i lo\u1ea1n t\u00e2m\/th\u1ec3. C\u00e1c tr\u01b0\u1eddng h\u1ee3p n\u00e0y c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o li\u00ean quan t\u1edbi vi\u1ec7c d\u00f9ng c\u00e1c thu\u1ed1c t\u00e1c \u0111\u1ed9ng l\u00ean th\u1ee5 th\u1ec3 benzodiazepine.<\/p>\n<p>C\u1ea7n d\u00f9ng Zopiclone th\u1eadn tr\u1ecdng cho b\u1ec7nh nh\u00e2n b\u1ecb nh\u01b0\u1ee3c c\u01a1 n\u1eb7ng ho\u1eb7c suy gi\u1ea3m ch\u1ee9c n\u0103ng gan n\u1eb7ng.<\/p>\n<p>B\u1ec7nh nh\u00e2n c\u1ea7n \u0111\u01b0\u1ee3c c\u1ea3nh b\u00e1o kh\u00f4ng n\u00ean d\u00f9ng Zopiclone trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p khi m\u00e0 h\u1ecd kh\u00f4ng c\u00f3 \u0111\u01b0\u1ee3c gi\u1ea5c ng\u1ee7 tr\u1ecdn \u0111\u00eam \u0111\u1ec3 thu\u1ed1c kh\u00f4ng \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb h\u1ebft ra kh\u1ecfi c\u01a1 th\u1ec3 tr\u01b0\u1edbc khi h\u1ecd ti\u1ebfp t\u1ee5c c\u00e1c ho\u1ea1t \u0111\u1ed9ng trong ng\u00e0y h\u00f4m sau.<\/p>\n<p>S\u1ef1 l\u00fa l\u1eabn: Benzodiazepine v\u00e0 c\u00e1c thu\u1ed1c t\u01b0\u01a1ng t\u1ef1 \u1ea3nh h\u01b0\u1edfng t\u1edbi kh\u1ea3 n\u0103ng tr\u00ed n\u00e3o nh\u01b0 s\u1ef1 t\u1eadp trung, ch\u00fa \u00fd v\u00e0 c\u1ea3nh gi\u00e1c. Nguy c\u01a1 d\u1eabn t\u1edbi l\u00fa l\u1eabn th\u01b0\u1eddng g\u1eb7p \u1edf ng\u01b0\u1eddi gi\u00e0 ho\u1eb7c b\u1ec7nh nh\u00e2n c\u00f3 c\u00e1c t\u1ed5n th\u01b0\u01a1ng n\u00e3o b\u1ed9.<\/p>\n<p>Lo l\u1eafng, b\u1ea5t an: Trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Zopiclone, ng\u01b0\u1eddi ta nh\u1eadn th\u1ea5y s\u1ef1 gia t\u0103ng t\u00ecnh tr\u1ea1ng lo l\u1eafng v\u00e0o ban ng\u00e0y v\u00e0\/ho\u1eb7c b\u1ea5t an. \u0110i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 do th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a thu\u1ed1c ng\u1eafn n\u00ean gi\u1eefa c\u00e1c li\u1ec1u d\u00f9ng xu\u1ea5t hi\u1ec7n t\u00ecnh tr\u1ea1ng t\u01b0\u01a1ng t\u1ef1 nh\u01b0 ng\u01b0ng thu\u1ed1c.<\/p>\n<p>Tr\u1ea7m c\u1ea3m: C\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng thu\u1ed1c cho b\u1ec7nh nh\u00e2n c\u00f3 d\u1ea5u hi\u1ec7u v\u00e0 tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh tr\u1ea7m c\u1ea3m, khi \u0111\u00f3 d\u00f9ng thu\u1ed1c ng\u1ee7 c\u00f3 th\u1ec3 l\u00e0m cho b\u1ec7nh tr\u1ea7m tr\u1ecdng th\u00eam. Nguy c\u01a1 t\u1ef1 d\u00f9ng qu\u00e1 li\u1ec1u l\u00e0 r\u1ea5t l\u1edbn \u1edf b\u1ec7nh nh\u00e2n b\u1ecb tr\u1ea7m c\u1ea3m, v\u00ec th\u1ebf ch\u1ec9 n\u00ean \u0111\u01b0a cho b\u1ec7nh nh\u00e2n m\u1ed9t l\u01b0\u1ee3ng thu\u1ed1c t\u1ed1i thi\u1ec3u \u0111\u1ee7 d\u00f9ng.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p>L\u1ea1m d\u1ee5ng, ph\u1ee5 thu\u1ed9c v\u00e0 r\u00fat thu\u1ed1c: Tr\u00e1nh ng\u01b0ng thu\u1ed1c \u0111\u1ed9t ng\u1ed9t v\u00e0 c\u1ea7n ph\u1ea3i gi\u1ea3m li\u1ec1u t\u1eeb t\u1eeb v\u1edbi b\u1ea5t k\u1ef3 b\u1ec7nh nh\u00e2n n\u00e0o d\u00f9ng thu\u1ed1c k\u00e9o d\u00e0i trong v\u00e0i tu\u1ea7n. Vi\u1ec7c gi\u1ea3m li\u1ec1u \u0111\u1eb7c bi\u1ec7t c\u1ea7n l\u01b0u \u00fd khi d\u00f9ng thu\u1ed1c cho b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed b\u1ecb co gi\u1eadt. Nguy c\u01a1 l\u1ec7 thu\u1ed9c thu\u1ed1c t\u0103ng \u1edf b\u1ec7nh nh\u00e2n \u0111\u00e3 t\u1eebng nghi\u1ec7n r\u01b0\u1ee3u, d\u00f9ng ma t\u00fay, ho\u1eb7c \u1edf c\u00e1c b\u1ec7nh nh\u00e2n b\u1ecb r\u1ed1i lo\u1ea1n nh\u00e2n c\u00e1ch. T\u00ecnh tr\u1ea1ng b\u1ec7nh nh\u00e2n b\u1ecb lo l\u1eafng ban ng\u00e0y trong kho\u1ea3ng th\u1eddi gian u\u1ed1ng thu\u1ed1c v\u00e0 lo l\u1eafng t\u00e1i ph\u00e1t c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 l\u1ec7 thu\u1ed9c thu\u1ed1c \u1edf b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Zopiclone.<\/p>\n<p>C\u0169ng nh\u01b0 c\u00e1c thu\u1ed1c an th\u1ea7n kh\u00e1c, c\u1ea7n h\u1ea1n ch\u1ebf d\u00f9ng thu\u1ed1c l\u1ea1i cho b\u1ec7nh nh\u00e2n \u0111ang \u0111\u01b0\u1ee3c theo d\u00f5i y t\u1ebf.<\/p>\n<p>B\u1ec7nh nh\u00e2n v\u1edbi c\u00e1c \u0111i\u1ec1u ki\u1ec7n \u0111\u1eb7c bi\u1ec7t: C\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng Zopiclone cho c\u00e1c b\u1ec7nh nh\u00e2n b\u1ecb suy gi\u1ea3m ch\u1ee9c n\u0103ng gan ho\u1eb7c th\u1eadn ho\u1eb7c b\u1ecb suy h\u00f4 h\u1ea5p n\u1eb7ng. \u1ee8c ch\u1ebf h\u00f4 h\u1ea5p \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn khi d\u00f9ng thu\u1ed1c cho c\u00e1c b\u1ec7nh nh\u00e2n b\u1ecb r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng h\u00f4 h\u1ea5p.<\/p>\n<p>B\u1ec7nh nh\u00e2n c\u1ea7n s\u1ef1 t\u1ec9nh t\u00e1o: Do t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng c\u1ee7a Zopiclone n\u00ean c\u1ea7n th\u1eadn tr\u1ecdng khi d\u00f9ng thu\u1ed1c cho b\u1ec7nh nh\u00e2n c\u00f3 th\u1ef1c hi\u1ec7n c\u00e1c c\u00f4ng vi\u1ec7c c\u1ea7n s\u1ef1 t\u1ec9nh t\u00e1o nh\u01b0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c hay l\u00e1i xe. C\u0169ng v\u1edbi l\u00fd do nh\u01b0 v\u1eady, c\u1ea7n c\u1ea3nh b\u00e1o b\u1ec7nh nh\u00e2n v\u1ec1 vi\u1ec7c d\u00f9ng \u0111\u1ed3ng th\u1eddi Zopiclone v\u00e0 r\u01b0\u1ee3u ho\u1eb7c c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng kh\u00e1c.<\/p>\n<p>D\u00f9ng thu\u1ed1c cho tr\u1ebb em: T\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 khi d\u00f9ng thu\u1ed1c cho tr\u1ebb em d\u01b0\u1edbi 18 tu\u1ed5i v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c l\u1eadp.<\/p>\n<p>D\u00f9ng thu\u1ed1c cho ng\u01b0\u1eddi gi\u00e0: D\u00f9ng thu\u1ed1c an th\u1ea7n li\u1ec1u cao kh\u00f4ng th\u00edch \u0111\u00e1ng \u1edf ng\u01b0\u1eddi gi\u00e0 c\u00f3 th\u1ec3 g\u00e2y ra h\u1eadu qu\u1ea3 kh\u00f4ng l\u01b0\u1eddng tr\u01b0\u1edbc \u0111\u01b0\u1ee3c. Do v\u1eady, c\u1ea7n d\u00f9ng li\u1ec1u th\u1ea5p nh\u1ea5t c\u00f3 th\u1ec3 cho c\u00e1c b\u1ec7nh nh\u00e2n l\u1edbn tu\u1ed5i.<\/p>\n<p><strong>T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n<p>M\u1eb7c d\u00f9 t\u00e1c d\u1ee5ng ph\u1ee5 hi\u1ebfm v\u00e0 th\u01b0\u1eddng \u1ea3nh h\u01b0\u1edfng kh\u00f4ng \u0111\u00e1ng k\u1ec3, nh\u01b0ng b\u1ec7nh nh\u00e2n kh\u00f4ng n\u00ean l\u00e1i xe hay v\u1eadn h\u00e0nh m\u00e1y m\u00f3c sau khi \u0111i\u1ec1u tr\u1ecb cho \u0111\u1ebfn khi x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c vi\u1ec7c th\u1ef1c hi\u1ec7n c\u00e1c c\u00f4ng vi\u1ec7c n\u00e0y c\u1ee7a h\u1ecd kh\u00f4ng b\u1ecb suy gi\u1ea3m. Nguy c\u01a1 s\u1ebd t\u0103ng khi s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi r\u01b0\u1ee3u.<\/p>\n<p><strong>4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/strong><\/p>\n<p><em>X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n<p>AU TGA pregnancy category: C<\/p>\n<p>US FDA pregnancy category: NA<\/p>\n<p><em>Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n<p>Tr\u1ebb em sinh ra b\u1edfi nh\u1eefng b\u00e0 m\u1eb9 d\u00f9ng benzodiazepins v\u00e0 c\u00e1c thu\u1ed1c t\u01b0\u01a1ng t\u1ef1 c\u00f3 nguy c\u01a1 m\u1eafc tri\u1ec7u ch\u1ee9ng r\u00fat thu\u1ed1c.<\/p>\n<p><em>Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n<p>Thu\u1ed1c b\u00e0i ti\u1ebft \u0111\u01b0\u1ee3c qua s\u1eefa n\u00ean kh\u00f4ng d\u00f9ng thu\u1ed1c cho ph\u1ee5 n\u1eef cho con b\u00fa.<\/p>\n<p><strong>4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/strong><\/p>\n<p>T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n th\u01b0\u1eddng g\u1eb7p nh\u1ea5t khi d\u00f9ng thu\u1ed1c l\u00e0 \u0111\u1eafng mi\u1ec7ng. T\u00ecnh tr\u1ea1ng qu\u00e1 u\u1ec3 o\u1ea3i, bu\u1ed3n ng\u1ee7 v\u00e0\/ho\u1eb7c m\u1ea5t ph\u1ed1i h\u1ee3p l\u00e0 d\u1ea5u hi\u1ec7u c\u1ee7a s\u1ef1 kh\u00f4ng dung n\u1ea1p thu\u1ed1c ho\u1eb7c qu\u00e1 li\u1ec1u.<\/p>\n<p>Nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 \u0111\u01b0\u1ee3c in nghi\u00eang th\u01b0\u1eddng g\u1eb7p h\u01a1n \u1edf Zopiclone so v\u1edbi placebo:<\/p>\n<p>H\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng: Bu\u1ed3n ng\u1ee7, suy nh\u01b0\u1ee3c, ch\u00f3ng m\u1eb7t, l\u00fa l\u1eabn, m\u1ea5t tr\u00ed nh\u1edb t\u1ea1m th\u1eddi, c\u1ea3m gi\u00e1c say r\u01b0\u1ee3u, s\u1ea3ng kho\u00e1i, \u00e1c m\u1ed9ng, t\u00e2m tr\u1ea1ng b\u1ed1i r\u1ed1i, lo \u00e2u ho\u1eb7c b\u1ed3n ch\u1ed3n, c\u1ea3m gi\u00e1c th\u00f9 \u0111\u1ecbch, tr\u1ea7m c\u1ea3m, gi\u1ea3m ham mu\u1ed1n t\u00ecnh d\u1ee5c, m\u1ea5t ph\u1ed1i h\u1ee3p, gi\u1ea3m tr\u01b0\u01a1ng l\u1ef1c c\u01a1, run, chu\u1ed9t r\u00fat, c\u1ea3m gi\u00e1c ki\u1ebfn b\u00f2, n\u00f3i kh\u00f3.<\/p>\n<p>Tim m\u1ea1ch: \u0110\u00e1nh tr\u1ed1ng ng\u1ef1c.<\/p>\n<p>Ti\u00eau h\u00f3a: Kh\u00f4 mi\u1ec7ng, tr\u1eafng l\u01b0\u1ee1i, h\u01a1i th\u1edf c\u00f3 m\u00f9i, bu\u1ed3n n\u00f4n, n\u00f4n, kh\u00f3 ti\u00eau, ti\u00eau ch\u1ea3y, t\u00e1o b\u00f3n, ch\u00e1n \u0103n ho\u1eb7c \u0103n nhi\u1ec1u.<\/p>\n<p>H\u00f4 h\u1ea5p: Kh\u00f3 th\u1edf.<\/p>\n<p>Gi\u00e1c quan: Gi\u1ea3m th\u1ecb l\u1ef1c.<\/p>\n<p>Da: Ng\u1ee9a, n\u1ed5i m\u1ea9n, t\u0103ng ti\u1ebft m\u1ed3 h\u00f4i. Ng\u1ee9a c\u00f3 th\u1ec3 l\u00e0 d\u1ea5u hi\u1ec7u m\u1eabn c\u1ea3m v\u1edbi thu\u1ed1c, khi \u0111\u00f3 n\u00ean ng\u01b0ng d\u00f9ng thu\u1ed1c.<\/p>\n<p>Chuy\u1ec3n h\u00f3a v\u00e0 dinh d\u01b0\u1ee1ng: S\u00fat c\u00e2n.<\/p>\n<p>C\u00e1c tri\u1ec7u ch\u1ee9ng kh\u00e1c: \u0110\u1eafng mi\u1ec7ng, \u0111au \u0111\u1ea7u, c\u1ea3m gi\u00e1c ch\u00e2n n\u1eb7ng, r\u00f9ng m\u00ecnh.<\/p>\n<p>C\u00e1c x\u00e9t nghi\u1ec7m: \u0110\u00f4i khi c\u00e1c x\u00e9t nghi\u1ec7m b\u1ecb \u1ea3nh h\u01b0\u1edfng khi d\u00f9ng thu\u1ed1c bao g\u1ed3m t\u0103ng AST, ALT ho\u1eb7c phosphatase ki\u1ec1m.<\/p>\n<p>Ng\u01b0\u1eddi cao tu\u1ed5i d\u1ec5 m\u1eafc c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 \u0111\u00e1nh tr\u1ed1ng ng\u1ef1c, n\u00f4n, ch\u00e1n \u0103n, t\u0103ng ti\u1ebft n\u01b0\u1edbc b\u1ecdt, l\u00fa l\u1eabn, t\u00e2m tr\u1ea1ng b\u1ed1i r\u1ed1i, lo \u00e2u, run v\u00e0 t\u0103ng ti\u1ebft m\u1ed3 h\u00f4i h\u01a1n \u1edf ng\u01b0\u1eddi tr\u1ebb.<\/p>\n<p><em>Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/strong><\/p>\n<p>Ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c. V\u1edbi c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i nh\u1eb9, th\u01b0\u1eddng ch\u1ec9 c\u1ea7n ng\u1eebng thu\u1ed1c. Tr\u01b0\u1eddng h\u1ee3p m\u1eabn c\u1ea3m n\u1eb7ng ho\u1eb7c ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, c\u1ea7n ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 (gi\u1eef tho\u00e1ng kh\u00ed v\u00e0 d\u00f9ng epinephrin, th\u1edf oxygen, d\u00f9ng kh\u00e1ng histamin, corticoid&#8230;).<\/p>\n<p><strong>4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/strong><\/p>\n<p>R\u01b0\u1ee3u c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng an th\u1ea7n c\u1ee7a thu\u1ed1c, \u0111\u1eb7c bi\u1ec7t l\u00e0m \u1ea3nh h\u01b0\u1edfng t\u1edbi kh\u1ea3 n\u0103ng l\u00e1i xe ho\u1eb7c v\u1eadn h\u00e0nh m\u00e1y m\u00f3c c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh khi d\u00f9ng \u0111\u1ed3ng th\u1eddi, do v\u1eady kh\u00f4ng n\u00ean ph\u1ed1i h\u1ee3p.<\/p>\n<p>D\u00f9ng thu\u1ed1c \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng s\u1ebd l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf th\u1ea7n kinh trung \u01b0\u01a1ng. Do v\u1eady c\u1ea7n c\u00e2n nh\u1eafc l\u1ee3i \u00edch \u0111i\u1ec1u tr\u1ecb khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi thu\u1ed1c ch\u1ed1ng lo\u1ea1n th\u1ea7n (thu\u1ed1c ng\u1ee7), thu\u1ed1c an th\u1ea7n, thu\u1ed1c ch\u1ed1ng lo \u00e2u\/l\u00e0m d\u1ecbu, thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m, thu\u1ed1c gi\u1ea3m \u0111au g\u00e2y ng\u1ee7, thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh, thu\u1ed1c m\u00ea v\u00e0 c\u00e1c thu\u1ed1c kh\u00e1ng histamin c\u00f3 t\u00e1c d\u1ee5ng an th\u1ea7n.<\/p>\n<p>D\u00f9ng k\u1ebft h\u1ee3p c\u00e1c thu\u1ed1c d\u1eabn ch\u1ea5t benzodiazepin ho\u1eb7c c\u00e1c thu\u1ed1c t\u01b0\u01a1ng t\u1ef1 v\u1edbi thu\u1ed1c gi\u1ea3m \u0111au g\u00e2y ng\u1ee7 c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng s\u1ea3ng kho\u00e1i v\u00e0 d\u1eabn t\u1edbi l\u1ec7 thu\u1ed9c thu\u1ed1c.<\/p>\n<p>Vi\u1ec7c d\u00f9ng ph\u1ed1i h\u1ee3p v\u1edbi thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf men gan (\u0111\u1eb7c bi\u1ec7t l\u00e0 Cyt P450) c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng c\u1ee7a c\u00e1c benzodiazepin v\u00e0 c\u00e1c thu\u1ed1c t\u01b0\u01a1ng t\u1ef1. Do Zopiclone \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a b\u1edfi CYP 3A4 n\u00ean n\u1ed3ng \u0111\u1ed9 trong m\u00e1u c\u1ee7a Zopiclone t\u0103ng l\u00ean khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf CYP 3A4 nh\u01b0 erythromycin, clarithromycin, ketoconazole, intraconazole v\u00e0 ritonavir. C\u1ea7n ph\u1ea3i gi\u1ea3m li\u1ec1u Zopiclone khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c thu\u1ed1c n\u00e0y.<\/p>\n<p>Ng\u01b0\u1ee3c l\u1ea1i, n\u1ed3ng \u0111\u1ed9 trong m\u00e1u c\u1ee7a Zopiclone gi\u1ea3m khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi thu\u1ed1c k\u00edch th\u00edch CYP 3A4 nh\u01b0 rifampicin, carmabazepin, phenobarbital, phenytoin. Khi \u0111\u00f3 c\u1ea7n ph\u1ea3i t\u0103ng li\u1ec1u d\u00f9ng c\u1ee7a Zopiclone.<\/p>\n<p><strong>4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/strong><\/p>\n<p>\u1ede ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n ho\u1eb7c do v\u00f4 t\u00ecnh u\u1ed1ng qu\u00e1 li\u1ec1u Zopiclone t\u1edbi 340mg, c\u00e1c tri\u1ec7u ch\u1ee9ng ch\u00ednh \u0111\u01b0\u1ee3c ghi nh\u1eadn bao g\u1ed3m: gi\u1ea5c ng\u1ee7 b\u1ecb k\u00e9o d\u00e0i, bu\u1ed3n ng\u1ee7, ng\u1ee7 l\u1ecbm v\u00e0 m\u1ea5t \u0111i\u1ec1u h\u00f2a. T\u1ea5t c\u1ea3 c\u00e1c bi\u1ec3u hi\u1ec7n qu\u00e1 li\u1ec1u c\u1ee7a Zopiclone c\u00f3 li\u00ean quan t\u1edbi \u0111\u1eb7c t\u00ednh d\u01b0\u1ee3c l\u00fd c\u1ee7a thu\u1ed1c: Bu\u1ed3n ng\u1ee7, l\u00fa l\u1eabn, ch\u00f3ng m\u1eb7t, gi\u1ea3m ho\u1eb7c m\u1ea5t ph\u1ea3n x\u1ea1.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb: \u0110i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 v\u00e0 theo c\u00e1c d\u1ea5u hi\u1ec7u l\u00e2m s\u00e0ng. C\u1ea7n theo d\u00f5i h\u00f4 h\u1ea5p, m\u1ea1ch v\u00e0 huy\u1ebft \u00e1p c\u1ee7a b\u1ec7nh nh\u00e2n v\u00e0 \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3 khi c\u1ea7n thi\u1ebft. C\u1ea7n r\u1eeda d\u1ea1 d\u00e0y ngay. Truy\u1ec1n d\u1ecbch t\u0129nh m\u1ea1ch v\u00e0 \u0111\u1ea3m b\u1ea3o th\u00f4ng kh\u00ed t\u1ed1t. Th\u1ea9m t\u00e1ch m\u00e1u kh\u00f4ng mang l\u1ea1i k\u1ebft qu\u1ea3. Flumazenil l\u00e0 thu\u1ed1c \u0111\u1ed1i kh\u00e1ng \u0111\u1eb7c hi\u1ec7u v\u1edbi th\u1ee5 th\u1ec3 c\u1ee7a benzodiazepin c\u00f3 th\u1ec3 d\u00f9ng trong tr\u01b0\u1eddng h\u1ee3p qu\u00e1 li\u1ec1u c\u1ee7a benzodiazepin v\u00e0 c\u00e1c thu\u1ed1c t\u01b0\u01a1ng t\u1ef1.<\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/strong><\/p>\n<p><strong>5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/strong><\/p>\n<p>Zopiclon thu\u1ed9c nh\u00f3m cyclopyrrolon c\u00f3 c\u00e1c \u0111\u1eb7c t\u00ednh t\u01b0\u01a1ng t\u1ef1 nh\u01b0 c\u00e1c d\u1eabn ch\u1ea5t c\u1ee7a benzodiazepin: an th\u1ea7n, gi\u1ea3i lo \u00e2u, gi\u00e3n c\u01a1, ch\u1ee9ng qu\u00ean v\u00e0 ch\u1ed1ng co gi\u1eadt. Thu\u1ed1c c\u00f3 t\u00e1c \u0111\u1ed9ng gi\u00e1n ti\u1ebfp l\u00e0m t\u0103ng ho\u1ea1t t\u00ednh c\u1ee7a acid gamma-aminobutyric (GABA) \u1edf n\u00e3o. Zopiclon g\u1eafn v\u1edbi th\u1ee5 th\u1ec3 benzodiazepin c\u1ee7a ph\u1ee9c h\u1ee3p th\u1ee5 th\u1ec3 GABA nh\u01b0ng \u1edf v\u1ecb tr\u00ed kh\u00e1c so v\u1edbi c\u00e1c d\u1eabn ch\u1ea5t benzodiazepin. Thu\u1ed1c c\u00f3 th\u1eddi gian t\u00e1c \u0111\u1ed9ng ng\u1eafn. Thu\u1ed1c t\u1ea1o gi\u1ea5c ng\u1ee7 kh\u1edfi \u0111\u1ea7u nhanh nh\u01b0ng kh\u00f4ng l\u00e0m gi\u1ea3m t\u1ed5ng th\u1eddi gian gi\u1ea5c ng\u1ee7 chuy\u1ec3n \u0111\u1ed9ng m\u1eaft nhanh (REM), v\u00e0 duy tr\u00ec gi\u1ea5c ng\u1ee7 s\u00f3ng ch\u1eadm b\u00ecnh th\u01b0\u1eddng. N\u00f3i chung, thu\u1ed1c \u0111\u01b0\u1ee3c xem c\u00f3 hi\u1ec7u l\u1ef1c nh\u01b0 l\u00e0 m\u1ed9t thu\u1ed1c ng\u1ee7 t\u01b0\u01a1ng t\u1ef1 c\u00e1c d\u1eabn ch\u1ea5t c\u1ee7a benzodiazepin.<\/p>\n<p><strong><em>C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n<p>\u0110\u1eb7c t\u00ednh d\u01b0\u1ee3c l\u1ef1c c\u1ee7a n\u00f3 bao g\u1ed3m g\u00e2y ng\u1ee7, an th\u1ea7n, ch\u1ed1ng lo \u00e2u, ch\u1ed1ng co gi\u1eadt v\u00e0 gi\u00e3n c\u01a1. C\u0169ng nh\u01b0 diazepam, t\u00e1c \u0111\u1ed9ng c\u1ee7a zopiclon c\u00f3 \u0111\u01b0\u1ee3c th\u00f4ng qua t\u0103ng c\u01b0\u1eddng ho\u1ea1t t\u00ednh c\u1ee7a gamma-aminobutyric acid (GABA) trong n\u00e3o. Zopiclon g\u1eafn v\u1edbi th\u00e0nh ph\u1ea7n th\u1ee5 th\u1ec3 benzodiazepin c\u1ee7a ph\u1ee9c h\u1ee3p th\u1ee5 th\u1ec3 GABA nh\u01b0ng \u1edf v\u1ecb tr\u00ed kh\u00e1c so v\u1edbi c\u00e1c benzodiazepin. Thu\u1ed1c c\u00f3 th\u1eddi gian t\u00e1c \u0111\u1ed9ng ng\u1eafn.<\/p>\n<p><strong>[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/p>\n<p><strong>5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/strong><\/p>\n<p>Zopiclon \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh v\u00e0 ph\u00e2n b\u1ed1 r\u1ed9ng r\u00e3i sau khi u\u1ed1ng. Thu\u1ed1c c\u00f3 th\u1eddi gian b\u00e1n th\u1ea3i sau 3,5 &#8211; 6,5 gi\u1edd v\u00e0 kho\u1ea3ng 45 &#8211; 80% thu\u1ed1c g\u1eafn k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng. Zopiclon \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a nhi\u1ec1u \u1edf gan; 2 ch\u1ea5t chuy\u1ec3n h\u00f3a ch\u00ednh, zopiclon N-oxyd \u00edt ho\u1ea1t t\u00ednh h\u01a1n v\u00e0 N-desmethyl-zopiclon kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh, \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu qua n\u01b0\u1edbc ti\u1ec3u. Kho\u1ea3ng 50% li\u1ec1u d\u00f9ng b\u1ecb bi\u1ebfn \u0111\u1ed5i do s\u1ef1 kh\u1eed carboxyl th\u00e0nh c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb m\u1ed9t ph\u1ea7n qua ph\u1ed5i d\u01b0\u1edbi d\u1ea1ng carbon dioxyd. Ch\u1ec9 kho\u1ea3ng 5% li\u1ec1u d\u00f9ng kh\u00f4ng \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a xu\u1ea5t hi\u1ec7n trong n\u01b0\u1edbc ti\u1ec3u v\u00e0 kho\u1ea3ng 16% \u1edf ph\u00e2n. Zopiclon c\u0169ng \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft qua n\u01b0\u1edbc b\u1ecdt do t\u1ea1o v\u1ecb \u0111\u1eafng. Thu\u1ed1c c\u0169ng \u0111\u01b0\u1ee3c ph\u00e2n b\u1ed1 v\u00e0o s\u1eefa m\u1eb9.<\/p>\n<p><strong>5.3 Gi\u1ea3i th\u00edch: <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong>5.4 Thay th\u1ebf thu\u1ed1c : <\/strong><\/p>\n<p>Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n<p><strong><em>*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n<p><strong><em>C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o &#8211; Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n<p><strong><em>Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n<p><script src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-5528370293090692\" async=\"\" crossorigin=\"anonymous\"><\/script><ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-5528370293090692\" data-ad-slot=\"8909623906\"><\/ins><script> (adsbygoogle = window.adsbygoogle || []).push({}); <\/script><\/p>\n<p><strong>6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/strong><\/p>\n<p><strong>6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/strong><\/p>\n<p>T\u00e1 d\u01b0\u1ee3c: Lactose Monohydrat, calci hydrogen phosphat dihydrat, tinh b\u1ed9t ti\u1ec1n galatin h\u00f3a, croscarmellose natri, magnesi stearat, hypromellose, titan dioxyd.<\/p>\n<p><strong>6.2. T\u01b0\u01a1ng k\u1ef5 :<\/strong><\/p>\n<p>Kh\u00f4ng \u00e1p d\u1ee5ng.<\/p>\n<p><strong>6.3. B\u1ea3o qu\u1ea3n: <\/strong><\/p>\n<p>N\u01a1i kh\u00f4, tr\u00e1nh \u00e1nh s\u00e1ng, nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30\u00b0C.<\/p>\n<p><strong>6.4. Th\u00f4ng tin kh\u00e1c :<\/strong><\/p>\n<p>Kh\u00f4ng c\u00f3.<\/p>\n<p><strong>6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/strong><\/p>\n<p>D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n","protected":false},"excerpt":{"rendered":"<p>1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Zopiclone Ph\u00e2n lo\u1ea1i: Thu\u00f4\u0301c an th\u00e2\u0300n g\u00e2y ngu\u0309. Nh\u00f3m ph\u00e1p l\u00fd: Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine) M\u00e3 ATC (Anatomical Therapeutic Chemical): N05CF01. Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c: Bi\u1ec7t d\u01b0\u1ee3c: PHAMZOPIC H\u00e3ng s\u1ea3n xu\u1ea5t : Pharmascience Inc.. 2. D\u1ea1ng b\u00e0o ch\u1ebf [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":14633,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[521],"class_list":["post-14632","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-zopiclone"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/14632","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=14632"}],"version-history":[{"count":3,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/14632\/revisions"}],"predecessor-version":[{"id":51554,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/14632\/revisions\/51554"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/14633"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=14632"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=14632"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=14632"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}