{"id":12982,"date":"2019-07-26T16:27:34","date_gmt":"2019-07-26T09:27:34","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=12982"},"modified":"2025-01-09T08:32:47","modified_gmt":"2025-01-09T01:32:47","slug":"atorvastatin-avasboston","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/atorvastatin-avasboston\/","title":{"rendered":"Atorvastatin – Avasboston"},"content":{"rendered":"

1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: <\/strong><\/p>\n

Ho\u1ea1t ch\u1ea5t :<\/em> Atorvastatin<\/strong><\/p>\n

Ph\u00e2n lo\u1ea1i: <\/em><\/strong>Thu\u1ed1c nh\u00f3m ch\u1ea5t \u1ee9c ch\u1ebf HMG-CoA reductase, nh\u00f3m statin.<\/em><\/p>\n

Nh\u00f3m<\/em><\/strong> ph\u00e1p l\u00fd: <\/em><\/strong>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n

M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): C10A A05.<\/p>\n

Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em><\/strong> LIPITOR<\/p>\n

Bi\u1ec7t d\u01b0\u1ee3c:<\/em><\/strong> AVASBOSTON<\/p>\n

H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: C\u00f4ng ty C\u1ed5 ph\u1ea7n D\u01b0\u1ee3c ph\u1ea9m Boston Vi\u1ec7t Nam.<\/p>\n

2. D\u1ea1ng b\u00e0o ch\u1ebf – H\u00e0m l\u01b0\u1ee3ng: <\/strong><\/p>\n

D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n

Vi\u00ean n\u00e9n bao phim 10 mg, 20 mg.<\/p>\n

Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n\n\n\n\n\n\n
AVASBOSTON 10<\/em><\/strong><\/td>\n<\/td>\n<\/tr>\n
M\u1ed7i vi\u00ean n\u00e9n c\u00f3 ch\u1ee9a:<\/em><\/td>\n<\/td>\n<\/tr>\n
Atorvastatin<\/td>\n………………………….<\/td>\n10 mg<\/td>\n<\/tr>\n
T\u00e1 d\u01b0\u1ee3c<\/td>\n………………………….<\/td>\nv\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/p>\n\n\n\n\n\n\n
AVASBOSTON 20<\/em><\/strong><\/td>\n<\/td>\n<\/tr>\n
M\u1ed7i vi\u00ean n\u00e9n c\u00f3 ch\u1ee9a:<\/em><\/td>\n<\/td>\n<\/tr>\n
Atorvastatin<\/td>\n………………………….<\/td>\n20 mg<\/td>\n<\/tr>\n
T\u00e1 d\u01b0\u1ee3c<\/td>\n………………………….<\/td>\nv\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/p>\n

3. Video by Pharmog:<\/strong><\/p>\n

[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n

————————————————<\/p>\n

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\u25ba Website: pharmog.com<\/p>\n

4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng: <\/strong><\/p>\n

4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n

B\u1ed5 tr\u1ee3 cho li\u1ec7u ph\u00e1p \u0103n u\u1ed1ng trong \u0111i\u1ec1u tr\u1ecb t\u0103ng cholesterol m\u00e1u nguy\u00ean ph\u00e1t (typ IIa) ho\u1eb7c r\u1ed1i lo\u1ea1n lipid m\u00e1u h\u1ed7n h\u1ee3p (typ IIb), t\u0103ng triglycerid m\u00e1u (typ IV).<\/p>\n

H\u1ed7 tr\u1ee3 d\u1ef1 ph\u00f2ng ti\u00ean ph\u00e1t bi\u1ebfn c\u1ed1 m\u1ea1ch v\u00e0nh \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 nhi\u1ec1u y\u1ebfu t\u1ed1 nguy c\u01a1 cao nh\u01b0ng ch\u01b0a c\u00f3 bi\u1ec3u hi\u1ec7n tri\u1ec7u ch\u1ee9ng tr\u00ean l\u00e2m s\u00e0ng.<\/p>\n

L\u00e0m ch\u1eadm ti\u1ebfn tri\u1ec3n x\u01a1 v\u1eefa m\u1ea1ch v\u00e0nh \u1edf b\u1ec7nh nh\u00e2n CHD.<\/p>\n

4.2. Li\u1ec1u d\u00f9ng – C\u00e1ch d\u00f9ng:<\/strong><\/p>\n

C\u00e1ch d\u00f9ng<\/em><\/strong> :<\/p>\n

D\u00f9ng b\u1eb1ng \u0111\u01b0\u1eddng u\u1ed1ng, c\u00f3 th\u1ec3 u\u1ed1ng li\u1ec1u duy nh\u1ea5t v\u00e0o b\u1ea5t c\u1ee9 l\u00fac n\u00e0o trong ng\u00e0y, c\u00f3 th\u1ec3 u\u1ed1ng thu\u1ed1c v\u00e0o b\u1eefa \u0103n ho\u1eb7c l\u00fac \u0111\u00f3i.<\/p>\n

Ng\u01b0\u1eddi b\u1ec7nh c\u1ea7n \u00e1p d\u1ee5ng ch\u1ebf \u0111\u1ed9 \u0103n ki\u00eang \u00edt cholesterol tr\u01b0\u1edbc khi u\u1ed1ng atorvastatin v\u00e0 duy tr\u00ec trong su\u1ed1t th\u1eddi gian d\u00f9ng thu\u1ed1c.<\/p>\n

Do t\u1ed5ng h\u1ee3p cholesterol \u1edf gan x\u1ea3y ra ch\u1ee7 y\u1ebfu v\u00e0o ban \u0111\u00eam, v\u00ec v\u1eady d\u00f9ng thu\u1ed1c v\u00e0o bu\u1ed5i t\u1ed1i s\u1ebd t\u0103ng hi\u1ec7u l\u1ef1c c\u1ee7a thu\u1ed1c.<\/p>\n

Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n

Khuy\u1ebfn c\u00e1o b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb li\u1ec1u l\u01b0\u1ee3ng theo nhu c\u1ea7u v\u00e0 \u0111\u00e1p \u1ee9ng c\u1ee7a t\u1eebng b\u1ec7nh nh\u00e2n, t\u0103ng hay gi\u1ea3m li\u1ec1u t\u1eebng \u0111\u1ee3t c\u00e1ch nhau kh\u00f4ng d\u01b0\u1edbi 4 tu\u1ea7n, cho t\u1edbi khi \u0111\u1ea1t n\u1ed3ng \u0111\u1ed9 cholesterol LDL mong mu\u1ed1n, ho\u1eb7c khi \u0111\u1ea1t li\u1ec1u t\u1ed1i \u0111a.<\/p>\n

Li\u1ec1u kh\u1edfi \u0111\u1ea7u: 10mg x 1 l\u1ea7n\/ng\u00e0y.<\/p>\n

Li\u1ec1u duy tr\u00ec: 10mg – 40mg\/ng\u00e0y.<\/p>\n

N\u1ebfu c\u1ea7n c\u00f3 th\u1ec3 t\u0103ng li\u1ec1u, nh\u01b0ng kh\u00f4ng qu\u00e1 80mg\/ng\u00e0y.<\/p>\n

Ph\u1ed1i h\u1ee3p thu\u1ed1c:<\/p>\n

Khi d\u00f9ng c\u00e1c statin c\u00f9ng v\u1edbi nh\u1ef1a g\u1eafn acid m\u1eadt (cholestyramin), ph\u1ea3i u\u1ed1ng statin v\u00e0o l\u00fac \u0111i ng\u1ee7, c\u00e1ch 2 gi\u1edd \u0111\u1ec3 tr\u00e1nh t\u01b0\u01a1ng t\u00e1c r\u00f5 r\u1ec7t do thu\u1ed1c g\u1eafn v\u00e0o nh\u1ef1a.<\/p>\n

H\u1ea1n ch\u1ebf ph\u1ed1i h\u1ee3p statin v\u1edbi c\u00e1c thu\u1ed1c h\u1ea1 lipid kh\u00e1c v\u00ec kh\u1ea3 n\u0103ng t\u0103ng nguy c\u01a1 b\u1ec7nh c\u01a1.<\/p>\n

\u0110\u1ed1i v\u1edbi tr\u1ebb em v\u00e0 tr\u1ebb v\u1ecb th\u00e0nh ni\u00ean t\u1eeb 10 \u0111\u1ebfn 17 tu\u1ed5i s\u1eed d\u1ee5ng li\u1ec1u ban \u0111\u1ea7u 10mg x1 l\u1ea7n\/ng\u00e0y v\u00e0 \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u sau m\u1ed7i 4 tu\u1ea7n \u0111\u1ec3 \u0111\u1ea1t \u0111\u1ebfn li\u1ec1u t\u1ed1i \u0111a 20mg x 1 l\u1ea7n\/ng\u00e0y.<\/p>\n

4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n

M\u1eabn c\u1ea3m v\u1edbi b\u1ea5t c\u1ee9 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n

Kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi atorvastatin v\u1edbi c\u00e1c thu\u1ed1c tipranavir + ritonavir, telaprevir.<\/p>\n

B\u1ec7nh gan ti\u1ebfn tri\u1ec3n ho\u1eb7c transaminase huy\u1ebft thanh t\u0103ng dai d\u1eb3ng m\u00e0 kh\u00f4ng gi\u1ea3i th\u00edch \u0111\u01b0\u1ee3c.<\/p>\n

Th\u1eddi k\u1ef3 mang thai ho\u1eb7c cho con b\u00fa.<\/p>\n

4.4 Th\u1eadn tr\u1ecdng:<\/strong><\/p>\n

Tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb v\u1edbi statin, c\u1ea7n ph\u1ea3i lo\u1ea1i tr\u1eeb c\u00e1c nguy\u00ean nh\u00e2n g\u00e2y t\u0103ng cholesterol m\u00e1u (nh\u01b0: \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng k\u00e9m ki\u1ec3m so\u00e1t, thi\u1ec3u n\u0103ng gi\u00e1p, h\u1ed9i ch\u1ee9ng th\u1eadn h\u01b0, r\u1ed1i lo\u1ea1n protein m\u00e1u, b\u1ec7nh gan t\u1eafc m\u1eadt, do d\u00f9ng m\u1ed9t s\u1ed1 thu\u1ed1c kh\u00e1c, nghi\u1ec7n r\u01b0\u1ee3u). Ph\u1ea3i ti\u1ebfn h\u00e0nh \u0111\u1ecbnh l\u01b0\u1ee3ng cholesterol to\u00e0n ph\u1ea7n, cholesterol LDL, cholesterol HDL v\u00e0 triglycerid.<\/p>\n

Ph\u1ea3i ti\u1ebfn h\u00e0nh \u0111\u1ecbnh l\u01b0\u1ee3ng lipid \u0111\u1ecbnh k\u1ef3, v\u1edbi kho\u1ea3ng c\u00e1ch kh\u00f4ng d\u01b0\u1edbi 4 tu\u1ea7n, v\u00e0 \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u l\u01b0\u1ee3ng theo \u0111\u00e1p \u1ee9ng c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh v\u1edbi thu\u1ed1c.<\/p>\n

C\u1ea7n c\u00e2n nh\u1eafc khi d\u00f9ng thu\u1ed1c thu\u1ed9c nh\u00f3m statin \u0111\u1ed1i v\u1edbi c\u00e1c b\u1ec7nh nh\u00e2n c\u00f3 nh\u1eefng y\u1ebfu t\u1ed1 nguy c\u01a1 d\u1eabn \u0111\u1ebfn t\u1ed5n th\u01b0\u01a1ng c\u01a1. C\u00e1c thu\u1ed1c thu\u1ed9c nh\u00f3m statin c\u00f3 nguy c\u01a1 g\u00e2y ra c\u00e1c ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i \u0111\u1ed1i v\u1edbi h\u1ec7 c\u01a1 nh\u01b0 teo c\u01a1, vi\u00eam c\u01a1, \u0111\u1eb7c bi\u1ec7t \u0111\u1ed1i v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 y\u1ebfu t\u1ed1 nguy c\u01a1 nh\u01b0 b\u1ec7nh nh\u00e2n tr\u00ean 65 tu\u1ed5i, b\u1ec7nh nh\u00e2n b\u1ecb b\u1ec7nh thi\u1ec3u n\u0103ng tuy\u1ebfn gi\u00e1p kh\u00f4ng \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t, b\u1ec7nh nh\u00e2n b\u1ecb b\u1ec7nh th\u1eadn. C\u1ea7n theo d\u00f5i ch\u1eb7t ch\u1ebd c\u00e1c ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i trong qu\u00e1 tr\u00ecnh d\u00f9ng thu\u1ed1c.<\/p>\n

Ph\u1ea3i t\u1ea1m ng\u1eebng \u0111i\u1ec1u tr\u1ecb ho\u1eb7c th\u00f4i h\u1eb3n \u1edf b\u1ea5t c\u1ee9 ng\u01b0\u1eddi b\u1ec7nh n\u00e0o c\u00f3 bi\u1ec3u hi\u1ec7n c\u1ee7a b\u1ec7nh c\u01a1 c\u1ea5p v\u00e0 n\u1eb7ng ho\u1eb7c c\u00f3 y\u1ebfu t\u1ed1 nguy c\u01a1 d\u1ec5 b\u1ecb suy th\u1eadn c\u1ea5p do ti\u00eau c\u01a1 v\u00e2n, nh\u01b0: nhi\u1ec5m khu\u1ea9n c\u1ea5p n\u1eb7ng, h\u1ea1 huy\u1ebft \u00e1p, ch\u1ea5n th\u01b0\u01a1ng n\u1eb7ng, b\u1ea5t th\u01b0\u1eddng v\u1ec1 chuy\u1ec3n h\u00f3a v\u00e0 n\u1ed9i ti\u1ebft co gi\u1eadt kh\u00f4ng ki\u1ec3m so\u00e1t…<\/p>\n

C\u1ea7n x\u00e9t nghi\u1ec7m enzym gan tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb v\u00e0 trong tr\u01b0\u1eddng h\u1ee3p ch\u1ec9 \u0111\u1ecbnh l\u00e2m s\u00e0ng y\u00eau c\u1ea7u x\u00e9t nghi\u1ec7m sau \u0111\u00f3. Th\u1eadn tr\u1ecdng khi d\u00f9ng thu\u1ed1c \u1edf ng\u01b0\u1eddi b\u1ec7nh u\u1ed1ng nhi\u1ec1u r\u01b0\u1ee3u v\u00e0\/ ho\u1eb7c c\u00f3 ti\u1ec1n s\u1eed b\u1ec7nh gan.<\/p>\n

C\u00e2n nh\u1eafc theo d\u00f5i creatin kinase (CK) trong tr\u01b0\u1eddng h\u1ee3p:<\/p>\n

Tr\u01b0\u1edbc khi \u0111i\u1ec1u tr\u1ecb, x\u00e9t nghi\u1ec7m CK n\u00ean \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh trong nh\u1eefng tr\u01b0\u1eddng h\u1ee3p: suy gi\u1ea3m ch\u1ee9c n\u0103ng gan th\u1eadn, nh\u01b0\u1ee3c gi\u00e1p, ti\u1ec1n s\u1eed b\u1ea3n th\u00e2n ho\u1eb7c ti\u1ec1n s\u1eed gia \u0111\u00ecnh m\u1eafc b\u1ec7nh c\u01a1 di truy\u1ec1n, ti\u1ec1n s\u1eed b\u1ecb b\u1ec7nh c\u01a1 do s\u1eed d\u1ee5ng statin ho\u1eb7c fibrat tr\u01b0\u1edbc \u0111\u00f3, ti\u1ec1n s\u1eed b\u1ec7nh gan v\u00e0\/ho\u1eb7c u\u1ed1ng nhi\u1ec1u r\u01b0\u1ee3u, b\u1ec7nh nh\u00e2n cao tu\u1ed5i (> 70) c\u00f3 nh\u1eefng y\u1ebfu t\u1ed1 nguy c\u01a1 b\u1ecb ti\u00eau c\u01a1 v\u00e2n, kh\u1ea3 n\u0103ng x\u1ea3y ra t\u01b0\u01a1ng t\u00e1c thu\u1ed1c v\u00e0 m\u1ed9t s\u1ed1 \u0111\u1ed1i t\u01b0\u1ee3ng b\u1ec7nh nh\u00e2n \u0111\u1eb7c bi\u1ec7t. Trong nh\u1eefng tr\u01b0\u1eddng h\u1ee3p n\u00e0y n\u00ean c\u00e2n nh\u1eafc l\u1ee3i \u00edch \/nguy c\u01a1 v\u00e0 theo d\u00f5i b\u1ec7nh nh\u00e2n tr\u00ean l\u00e2m s\u00e0ng khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng statin. N\u1ebfu k\u1ebft qu\u1ea3 x\u00e9t nghi\u1ec7m CK > 5 l\u1ea7n gi\u1edbi h\u1ea1n tr\u00ean c\u1ee7a m\u1ee9c b\u00ecnh th\u01b0\u1eddng, kh\u00f4ng n\u00ean b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb b\u1eb1ng statin.<\/p>\n

Trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb b\u1eb1ng statin, b\u1ec7nh nh\u00e2n c\u1ea7n th\u00f4ng b\u00e1o khi c\u00f3 nh\u1eefng bi\u1ec3u hi\u1ec7n v\u1ec1 c\u01a1 nh\u01b0 \u0111au c\u01a1, c\u1ee9ng c\u01a1, y\u1ebfu c\u01a1… Khi c\u00f3 c\u00e1c bi\u1ec3u hi\u1ec7n n\u00e0y, b\u1ec7nh nh\u00e2n c\u1ea7n l\u00e0m x\u00e9t nghi\u1ec7m CK \u0111\u1ec3 c\u00f3 c\u00e1c bi\u1ec7n ph\u00e1p can thi\u1ec7p ph\u00f9 h\u1ee3p.<\/p>\n

Ch\u1ec9 d\u00f9ng atorvastatin cho ph\u1ee5 n\u1eef trong \u0111\u1ed9 tu\u1ed5i sinh \u0111\u1ebb khi ch\u1eafc ch\u1eafn kh\u00f4ng mang thai v\u00e0 ch\u1ec9 trong tr\u01b0\u1eddng h\u1ee3p cholesterol m\u00e1u t\u0103ng r\u1ea5t cao m\u00e0 kh\u00f4ng \u0111\u00e1p \u1ee9ng v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c.<\/p>\n

T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n

N\u00ean th\u1eadn tr\u1ecdng khi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c, v\u00ec thu\u1ed1c g\u00e2y tri\u1ec7u ch\u1ee9ng ch\u00f3ng m\u1eb7t…<\/p>\n

4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/strong><\/p>\n

X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n

AU TGA pregnancy category: D<\/p>\n

US FDA pregnancy category: X<\/p>\n

Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n

V\u00ec thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p cholesterol v\u00e0 ph\u00e2n b\u1ed1 v\u00e0o s\u1eefa n\u00ean thu\u1ed1c ch\u1ed1ng chi \u0111\u1ecbnh v\u1edbi ph\u1ee5 n\u1eef c\u00f3 thai ho\u1eb7c cho con b\u00fa.<\/p>\n

Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n

V\u00ec thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p cholesterol v\u00e0 ph\u00e2n b\u1ed1 v\u00e0o s\u1eefa n\u00ean thu\u1ed1c ch\u1ed1ng chi \u0111\u1ecbnh v\u1edbi ph\u1ee5 n\u1eef c\u00f3 thai ho\u1eb7c cho con b\u00fa.<\/p>\n

4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/strong><\/p>\n

N\u00f3i chung statin dung n\u1ea1p t\u1ed1t, t\u1ef7 l\u1ec7 ph\u1ea3i ng\u1eebng thu\u1ed1c th\u1ea5p h\u01a1n so v\u1edbi c\u00e1c thu\u1ed1c h\u1ea1 lipid kh\u00e1c.<\/p>\n

Suy gi\u1ea3m nh\u1eadn th\u1ee9c (nh\u01b0 m\u1ea5t tr\u00ed nh\u1edb, l\u00fa l\u1eabn…), t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft, t\u0103ng HbA1c.<\/p>\n

Th\u01b0\u1eddng g\u1eb7p: ti\u00eau ch\u1ea3y, t\u00e1o b\u00f3n, \u0111\u1ea7y h\u01a1i, \u0111au b\u1ee5ng, bu\u1ed3n n\u00f4n, nh\u1ee9c \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, nh\u00ecn m\u1edd, m\u1ea5t ng\u1ee7, suy nh\u01b0\u1ee3c, \u0111au c\u01a1, \u0111au kh\u1edbp. K\u1ebft qu\u1ea3 th\u1eed nghi\u1ec7m ch\u1ee9c n\u0103ng gan t\u0103ng h\u01a1n 3 l\u1ea7n gi\u1edbi h\u1ea1n tr\u00ean c\u1ee7a b\u00ecnh th\u01b0\u1eddng.<\/p>\n

\u00cdt g\u1eb7p: b\u1ec7nh c\u01a1, ban da, vi\u00eam m\u0169i, vi\u00eam xoang, vi\u00eam h\u1ecdng, ho.<\/p>\n

Hi\u1ebfm g\u1eb7p: vi\u00eam c\u01a1, ti\u00eau c\u01a1 v\u00e2n d\u1eabn \u0111\u1ebfn suy th\u1eadn c\u1ea5p th\u1ee9 ph\u00e1t do myoglobin ni\u1ec7u.<\/p>\n

Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n

4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/strong><\/p>\n

C\u00e1c thay \u0111\u1ed5i n\u1ed3ng \u0111\u1ed9 enzym gan trong huy\u1ebft thanh th\u01b0\u1eddng x\u1ea3y ra \u1edf nh\u1eefng th\u00e1ng \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb b\u1eb1ng statin. Ng\u01b0\u1eddi b\u1ec7nh n\u00e0o c\u00f3 n\u1ed3ng \u0111\u1ed9 transaminase huy\u1ebft thanh cao ph\u1ea3i theo d\u00f5i x\u00e9t nghi\u1ec7m ch\u1ee9c n\u0103ng gan l\u1ea7n th\u1ee9 hai \u0111\u1ec3 x\u00e1c nh\u1eadn k\u1ebft qu\u1ea3 v\u00e0 theo d\u00f5i \u0111i\u1ec1u tr\u1ecb cho t\u1edbi khi c\u00e1c b\u1ea5t th\u01b0\u1eddng tr\u1edf v\u1ec1 b\u00ecnh th\u01b0\u1eddng. N\u1ebfu n\u1ed3ng \u0111\u1ed9 transaminase huy\u1ebft thanh AST ho\u1eb7c ALT (GOT ho\u1eb7c GPT) dai d\u1eb3ng l\u00ean qu\u00e1 3 l\u1ea7n gi\u1edbi h\u1ea1n tr\u00ean c\u1ee7a b\u00ecnh th\u01b0\u1eddng, th\u00ec ph\u1ea3i ng\u1eebng \u0111i\u1ec1u tr\u1ecb b\u1eb1ng statin.<\/p>\n

Ph\u1ea3i khuy\u00ean ng\u01b0\u1eddi b\u1ec7nh d\u00f9ng statin b\u00e1o c\u00e1o ngay b\u1ea5t k\u1ef3 bi\u1ec3u hi\u1ec7n n\u00e0o nh\u01b0 \u0111au c\u01a1 kh\u00f4ng r\u00f5 l\u00fd do, nh\u1ea1y c\u1ea3m \u0111au v\u00e0 y\u1ebfu c\u01a1, \u0111\u1eb7c bi\u1ec7t n\u1ebfu k\u00e8m theo kh\u00f3 ch\u1ecbu ho\u1eb7c s\u1ed1t. Ph\u1ea3i ng\u1eebng li\u1ec7u ph\u00e1p statin n\u1ebfu n\u1ed3ng \u0111\u1ed9 CPK t\u0103ng r\u00f5 r\u1ec7t, cao h\u01a1n 10 l\u1ea7n gi\u1edbi h\u1ea1n tr\u00ean c\u1ee7a b\u00ecnh th\u01b0\u1eddng v\u00e0 n\u1ebfu ch\u1ea5n \u0111o\u00e1n ho\u1eb7c nghi ng\u1edd l\u00e0 b\u1ec7nh c\u01a1<\/p>\n

4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/strong><\/p>\n

T\u0103ng nguy c\u01a1 t\u1ed5n th\u01b0\u01a1ng c\u01a1 khi s\u1eed d\u1ee5ng atorvastatin v\u1edbi c\u00e1c thu\u1ed1c sau: gemfibrozil, c\u00e1c thu\u1ed1c h\u1ea1 cholesterol m\u00e1u nh\u00f3m firat kh\u00e1c, niacin \u1edf li\u1ec1u cao (> 1g\/ng\u00e0y), colchicin, erythromycin, itraconazol, ketoconazol (do \u1ee9c ch\u1ebf cytocrom CYP 3A4), cyclosporin.<\/p>\n

Thu\u1ed1c c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng c\u1ee7a warfarin. Ph\u1ea3i x\u00e1c \u0111\u1ecbnh th\u1eddi gian prothrombin tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u d\u00f9ng statin v\u00e0 theo d\u00f5i th\u01b0\u1eddng xuy\u00ean trong th\u1eddi gian \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o kh\u00f4ng c\u00f3 thay \u0111\u1ed5i nhi\u1ec1u v\u1ec1 th\u1eddi gian prothrombin.<\/p>\n

C\u00e1c nh\u1ef1a g\u1eafn acid m\u1eadt c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m r\u00f5 r\u1ec7t kh\u1ea3 d\u1ee5ng sinh h\u1ecdc c\u1ee7a atorvastatin khi u\u1ed1ng c\u00f9ng, v\u00ec v\u1eady ph\u1ea3i d\u00f9ng 2 thu\u1ed1c n\u00e0y c\u00e1ch xa nhau.<\/p>\n

Kh\u00f4ng th\u1ea5y c\u00f3 bi\u1ec3u hi\u1ec7n t\u01b0\u01a1ng t\u00e1c c\u00f3 h\u1ea1i c\u00f3 \u00fd ngh\u0129a tr\u00ean l\u00e2m s\u00e0ng khi s\u1eed d\u1ee5ng atorvastatin v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n, c\u00e1c thu\u1ed1c ch\u1eb9n beta, thu\u1ed1c l\u1ee3i ti\u1ec3u v\u00e0 thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid.<\/p>\n

Vi\u1ec7c s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi c\u00e1c thu\u1ed1c h\u1ea1 lipid m\u00e1u nh\u00f3m statin v\u1edbi c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb HIV v\u00e0 vi\u00eam gan si\u00eau vi C (HCV) c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 g\u00e2y t\u1ed5n th\u01b0\u01a1ng c\u01a1, nghi\u00eam tr\u1ecdng nh\u1ea5t l\u00e0 ti\u00eau c\u01a1 v\u00e2n, th\u1eadn h\u01b0 d\u1eabn \u0111\u1ebfn suy th\u1eadn v\u00e0 c\u00f3 th\u1ec3 g\u00e2y t\u1eed vong.<\/p>\n

S\u1eed d\u1ee5ng th\u1eadn tr\u1ecdng v\u00e0 n\u1ebfu c\u1ea7n thi\u1ebft n\u00ean d\u00f9ng li\u1ec1u atorvastatin th\u1ea5p nh\u1ea5t khi d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi thu\u1ed1c lopinavir + ritonavir.<\/p>\n

Kh\u00f4ng n\u00ean d\u00f9ng atorvastatin qu\u00e1 20mg\/ng\u00e0y khi d\u00f9ng ph\u1ed1i h\u1ee3p v\u1edbi amiodarone, darunavir + ritonavir, fosamprenavir, fosamprenavir + ritonavir, saquinavir + ritonavir v\u00e0 kh\u00f4ng qu\u00e1 40mg atorvastatin \/ng\u00e0y khi s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi v\u1edbi nelfinavir v\u00ec l\u00e0m t\u0103ng nguy c\u01a1 g\u00e2y ra ch\u1ee9ng ti\u00eau c\u01a1 v\u00e2n.<\/p>\n

4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/strong><\/p>\n

Qu\u00e1 li\u1ec1u: Kh\u00f4ng c\u00f3 tri\u1ec7u ch\u1ee9ng \u0111\u1eb7c bi\u1ec7t khi d\u00f9ng thu\u1ed1c qu\u00e1 li\u1ec1u.<\/p>\n

X\u1eed tr\u00ed: Kh\u00f4ng c\u00f3 \u0111i\u1ec1u tr\u1ecb \u0111\u1eb7c hi\u1ec7u cho qu\u00e1 li\u1ec1u c\u1ee7a atorvastatin. N\u1ebfu c\u00f3 x\u1ea3y ra qu\u00e1 li\u1ec1u, c\u1ea7n \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng h\u1ed7 tr\u1ee3 khi c\u1ea7n thi\u1ebft. Do c\u00f3 \u0111\u1ed9 g\u1eafn k\u1ebft cao v\u1edbi protein c\u1ee7a huy\u1ebft t\u01b0\u01a1ng, n\u00ean th\u1ea9m ph\u00e2n l\u1ecdc m\u00e1u kh\u00f3 c\u00f3 th\u1ec3 l\u00e0m t\u0103ng \u0111\u00e1ng k\u1ec3 \u0111\u1ed9 thanh th\u1ea3i c\u1ee7a atorvastatin.<\/p>\n

5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/strong><\/p>\n

5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/strong><\/p>\n

Atorvastatin thu\u1ed9c nh\u00f3m statin, l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf c\u1ea1nh tranh v\u1edbi hydroxymethylglutaryl coenzym (HMG-CoA) reductase, l\u00e0m ng\u0103n c\u1ea3n chuy\u1ec3n h\u00f3a HMG-CoA th\u00e0nh mevalonat, ti\u1ec1n ch\u1ea5t c\u1ee7a cholesterol.<\/p>\n

Atorvastatin \u1ee9c ch\u1ebf sinh t\u1ed5ng h\u1ee3p cholesterol, l\u00e0m gi\u1ea3m cholesterol trong t\u1ebf b\u00e0o gan, k\u00edch th\u00edch t\u1ed5ng h\u1ee3p th\u1ee5 th\u1ec3 LDL v\u00e0 qua \u0111\u00f3 l\u00e0m t\u0103ng v\u1eadn chuy\u1ec3n LDL t\u1eeb m\u00e1u. K\u1ebft qu\u1ea3 c\u1ee7a nh\u1eefng qu\u00e1 tr\u00ecnh h\u00f3a sinh n\u00e0y l\u00e0 gi\u1ea3m n\u1ed3ng \u0111\u1ed9 cholesterol trong huy\u1ebft t\u01b0\u01a1ng. L\u00e0m gi\u1ea3m cholesterol LDL t\u1eeb 25 – 61%, t\u0103ng n\u1ed3ng \u0111\u1ed9 cholesterol HDL t\u1eeb 5 – 15%, gi\u1ea3m triglycerid huy\u1ebft t\u01b0\u01a1ng t\u1eeb 10 – 30%.<\/p>\n

C\u00e1c statin c\u0169ng c\u00f3 vai tr\u00f2 trong d\u1ef1 ph\u00f2ng ti\u00ean ph\u00e1t (c\u1ea5p 1) b\u1ec7nh m\u1ea1ch v\u00e0nh \u1edf ng\u01b0\u1eddi b\u1ec7nh t\u0103ng cholesterol c\u00f3 nguy c\u01a1 m\u1eafc bi\u1ebfn c\u1ed1 m\u1ea1ch v\u00e0nh.<\/p>\n

C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n

Atorvastatin l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf c\u1ea1nh tranh v\u00e0 ch\u1ecdn l\u1ecdc men kh\u1eed HMG-CoA, m\u1ed9t men quy\u1ebft \u0111\u1ecbnh v\u1ec1 m\u1ee9c \u0111\u1ed9 trong qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p cholesterol chuy\u1ec3n \u0111\u1ed5i HMG-Co-A th\u00e0nh meyalonat, m\u1ed9t ti\u1ec1n ch\u1ea5t c\u1ee7a c\u00e1c sterol, bao g\u1ed3m c\u1ea3 cholesterol. \u1ede c\u00e1c b\u1ec7nh nh\u00e2n c\u00f3 t\u0103ng cholesterol m\u00e1u c\u00f3 t\u00ednh gia \u0111\u00ecnh \u0111\u1ed3ng h\u1ee3p t\u1eed v\u00e0 d\u1ecb h\u1ee3p t\u1eed, c\u00e1c th\u1ec3 t\u0103ng cholesterol m\u00e1u kh\u00f4ng c\u00f3 t\u00ednh gia \u0111\u00ecnh, v\u00e0 r\u1ed1i lo\u1ea1n lipid m\u00e1u h\u1ed7n h\u1ee3p, Atorvastatin l\u00e0m gi\u1ea3m C-to\u00e0n ph\u1ea7n, LDL-C, v\u00e0 apo B. Atorvastatin c\u0169ng l\u00e0m gi\u1ea3m cholesterol lipoprotein t\u1ef7 tr\u1ecdng r\u1ea5t th\u1ea5p (VLDL-C) v\u00e0 triglyceridv\u00e0 l\u00e0m t\u0103ng nh\u1eb9 HDL-C.<\/p>\n

Atorvastatin l\u00e0m gi\u1ea3m cholesterol v\u00e0 lipoprotein huy\u1ebft t\u01b0\u01a1ng b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf men kh\u1eed HMG-CoA reductase v\u00e0 qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p cholesterol \u1edf gan v\u00e0 b\u1eb1ng c\u00e1ch l\u00e0m t\u0103ng s\u1ed1 l\u01b0\u1ee3ng c\u00e1c th\u1ee5 th\u1ec3 LDL t\u1ea1i gan tr\u00ean t\u1ebf b\u00e0o b\u1ec1 m\u1eb7t \u0111\u1ec3 l\u00e0m t\u0103ng qu\u00e1 tr\u00ecnh thu h\u1ed3i v\u00e0 chuy\u1ec3n h\u00f3a LDL.<\/p>\n

Atorvastatin l\u00e0m gi\u1ea3m qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t LDL v\u00e0 s\u1ed1 l\u01b0\u1ee3ng c\u00e1c ti\u1ec3u ph\u00e2n LDL. Atorvastatin l\u00e0m t\u0103ng m\u1ea1nh v\u00e0 duy tr\u00ec ho\u1ea1t t\u00ednh c\u00e1c th\u1ee5 th\u1ec3 LDL k\u00e8m theo c\u00e1c thay \u0111\u1ed5i c\u00f3 l\u1ee3i v\u1ec1 ch\u1ea5t l\u01b0\u1ee3ng c\u1ee7a c\u00e1c ti\u1ec3u ph\u00e2n LDL l\u01b0u th\u00f4ng. Atorvastatin c\u00f3 hi\u1ec7u qu\u1ea3 trong vi\u1ec7c gi\u1ea3m LDL \u1edf c\u00e1c b\u1ec7nh nh\u00e2n c\u00f3 t\u0103ng cholesterol m\u00e1u c\u00f3 t\u00ednh gia \u0111\u00ecnh \u0111\u1ed3ng h\u1ee3p t\u1eed, nh\u00f3m \u0111\u1ed1i t\u01b0\u1ee3ng th\u01b0\u1eddng kh\u00f4ng \u0111\u00e1p \u1ee9ng v\u1edbi c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb h\u1ea1 lipid.<\/p>\n

Atorvastatin v\u00e0 m\u1ed9t s\u1ed1 ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a n\u00f3 c\u00f3 ho\u1ea1t t\u00ednh d\u01b0\u1ee3c l\u00fd \u1edf ng\u01b0\u1eddi. V\u1ecb tr\u00ed t\u00e1c d\u1ee5ng ch\u1ee7 y\u1ebfu c\u1ee7a Atorvastatin l\u00e0 \u1edf gan, \u0111\u00e2y l\u00e0 n\u01a1i ch\u1ee7 y\u1ebfu t\u1ed5ng h\u1ee3p cholesterol v\u00e0 \u0111\u00e0o th\u1ea3i LDL-C. Hi\u1ec7u qu\u1ea3 gi\u1ea3m LDL-C t\u01b0\u01a1ng quan ch\u1eb7t ch\u1ebd v\u1edbi li\u1ec1u thu\u1ed5c s\u1eed d\u1ee5ng h\u01a1n l\u00e0 v\u1edbi n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong tu\u1ea7n ho\u00e0n. C\u1ea7n d\u1ef1a tr\u00ean \u0111\u00e1p \u1ee9ng \u0111i\u1ec1u tr\u1ecb \u0111\u1ec3 c\u1ee5 th\u1ec3 h\u00f3a li\u1ec1u d\u00f9ng cho t\u1eebng b\u1ec7nh nh\u00e2n (xem ph\u1ea7n Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch d\u00f9ng).<\/p>\n

[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/p>\n

5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/strong><\/p>\n

H\u1ea5p thu nhanh b\u1eb1ng \u0111\u01b0\u1eddng u\u1ed1ng, kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi th\u1ee9c \u0103n.<\/p>\n

Kh\u1ea3 d\u1ee5ng sinh h\u1ecdc th\u1ea5p v\u00ec chuy\u1ec3n h\u00f3a l\u1ea7n \u0111\u1ea7u \u1edf gan (> 60%). N\u1ed3ng \u0111\u1ed9 \u0111inh trong huy\u1ebft thanh c\u1ee7a nh\u1eefng ch\u1ea5t c\u00f3 ho\u1ea1t t\u00ednh \u0111\u1ea1t trong v\u00f2ng 1 \u0111\u1ebfn 2 gi\u1edd, li\u00ean k\u1ebft v\u1edbi protein h\u01a1n 98% v\u00e0 \u0111i qua \u0111\u01b0\u1ee3c h\u00e0ng r\u00e0o m\u00e1u n\u00e3o.<\/p>\n

Chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu \u1edf gan (> 70%) th\u00e0nh c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u00f3 ho\u1eb7c kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh.<\/p>\n

Thu\u1ed1c \u0111\u01b0\u1ee3c th\u1ea3i tr\u1eeb ch\u1ee7 y\u1ebfu qua ph\u00e2n v\u00e0 m\u1ed9t ph\u1ea7n nh\u1ecf (< 2%) qua n\u01b0\u1edbc ti\u1ec3u.<\/p>\n

5.3 Gi\u1ea3i th\u00edch: <\/strong><\/p>\n

Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n

5.4 Thay th\u1ebf thu\u1ed1c : <\/strong><\/p>\n

Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n

*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n

C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o – Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n

Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n

6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/strong><\/p>\n

6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/strong><\/p>\n

T\u00e1 d\u01b0\u1ee3c:<\/em>\u00a0Avicel, calci carbonat, lactose monohydrat, pregelatinized starch, natri croscarmellose, povidon K30, polysorbat 80, magnesi stearat, HPMC 606, HPMC 615, b\u1ed9t Talc, PEG 6000, titan dioxyd, aerosil v\u1eeba \u0111\u1ee7 1 vi\u00ean n\u00e9n bao phim.<\/p>\n

6.2. T\u01b0\u01a1ng k\u1ef5 :<\/strong><\/p>\n

Kh\u00f4ng \u00e1p d\u1ee5ng.<\/p>\n

6.3. B\u1ea3o qu\u1ea3n: <\/strong><\/p>\n

N\u01a1i kh\u00f4, tr\u00e1nh \u00e1nh s\u00e1ng, nhi\u1ec7t \u0111\u1ed9 d\u01b0\u1edbi 30\u00b0C.<\/p>\n

6.4. Th\u00f4ng tin kh\u00e1c :<\/strong><\/p>\n

Kh\u00f4ng c\u00f3.<\/p>\n

6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/strong><\/p>\n

D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n","protected":false},"excerpt":{"rendered":"

1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Atorvastatin Ph\u00e2n lo\u1ea1i: Thu\u1ed1c nh\u00f3m ch\u1ea5t \u1ee9c ch\u1ebf HMG-CoA reductase, nh\u00f3m statin. Nh\u00f3m ph\u00e1p l\u00fd: Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine) M\u00e3 ATC (Anatomical Therapeutic Chemical): C10A A05. Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c: LIPITOR Bi\u1ec7t d\u01b0\u1ee3c: AVASBOSTON H\u00e3ng s\u1ea3n xu\u1ea5t : […]<\/p>\n","protected":false},"author":1,"featured_media":12986,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[443],"class_list":["post-12982","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-atorvastatin"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/12982","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=12982"}],"version-history":[{"count":1,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/12982\/revisions"}],"predecessor-version":[{"id":12987,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/12982\/revisions\/12987"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/12986"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=12982"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=12982"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=12982"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}