{"id":11967,"date":"2019-06-30T18:30:07","date_gmt":"2019-06-30T11:30:07","guid":{"rendered":"https:\/\/pharmog.com\/wp\/?p=11967"},"modified":"2025-01-08T23:23:37","modified_gmt":"2025-01-08T16:23:37","slug":"aspirine-aspirin-81","status":"publish","type":"post","link":"https:\/\/pharmog.com\/wp\/aspirine-aspirin-81\/","title":{"rendered":"Aspirine – Aspirin 81"},"content":{"rendered":"

1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: <\/strong><\/p>\n

Ho\u1ea1t ch\u1ea5t :<\/em> Acetylsalicylic acid (Aspirin)<\/strong><\/p>\n

Ph\u00e2n lo\u1ea1i: <\/em><\/strong>Thu\u00f4\u0301c kha\u0301ng vi\u00eam Non-steroid (NSAIDS), thu\u1ed1c \u1ee9c ch\u1ebf k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u.<\/em><\/p>\n

Nh\u00f3m<\/em><\/strong> ph\u00e1p l\u00fd: <\/em><\/strong>Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine)<\/em><\/p>\n

M\u00e3 ATC<\/em><\/strong> (Anatomical Therapeutic Chemical): B01AC06.<\/p>\n

Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c:<\/em><\/strong><\/p>\n

Bi\u1ec7t d\u01b0\u1ee3c:<\/em><\/strong> ASPIRIN 81<\/p>\n

H\u00e3ng s\u1ea3n xu\u1ea5t <\/em><\/strong>: C\u00f4ng ty c\u1ed5 ph\u1ea7n xu\u1ea5t nh\u1eadp kh\u1ea9u y t\u1ebf Domesco<\/p>\n

2. D\u1ea1ng b\u00e0o ch\u1ebf H\u00e0m l\u01b0\u1ee3ng: <\/strong><\/p>\n

D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng<\/em><\/strong><\/p>\n

Vi\u00ean n\u00e9n bao phim tan trong ru\u1ed9t 80mg.<\/p>\n

Thu\u1ed1c tham kh\u1ea3o:<\/em><\/strong><\/p>\n\n\n\n\n\n\n
ASPIRIN 81<\/em><\/strong><\/td>\n<\/td>\n<\/tr>\n
M\u1ed7i vi\u00ean n\u00e9n bao phim c\u00f3 ch\u1ee9a:<\/em><\/td>\n<\/td>\n<\/tr>\n
Aspirin<\/td>\n………………………….<\/td>\n80 mg<\/td>\n<\/tr>\n
T\u00e1 d\u01b0\u1ee3c<\/td>\n………………………….<\/td>\nv\u1eeba \u0111\u1ee7 (Xem m\u1ee5c 6.1)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/p>\n

3. Video by Pharmog:<\/strong><\/p>\n

[VIDEO D\u01af\u1ee2C L\u00dd]<\/strong><\/p>\n

————————————————<\/p>\n

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4. \u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng: <\/strong><\/p>\n

4.1. Ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n

Ph\u00f2ng ng\u1eeba nguy\u00ean ph\u00e1t v\u00e0 d\u1ef1 ph\u00f2ng th\u1ee9 ph\u00e1t nh\u1ed3i m\u00e1u c\u01a1 tim, \u0111\u1ed9t qu\u1ef5.<\/p>\n

4.2. Li\u1ec1u d\u00f9ng C\u00e1ch d\u00f9ng:<\/strong><\/p>\n

C\u00e1ch d\u00f9ng<\/em><\/strong> : D\u00f9ng u\u1ed1ng.<\/p>\n

U\u1ed1ng nguy\u00ean vi\u00ean thu\u1ed1c sau khi \u0103n, kh\u00f4ng \u0111\u01b0\u1ee3c nhai hay nghi\u1ec1n ra.<\/p>\n

Li\u1ec1u d\u00f9ng:<\/em><\/strong><\/p>\n

Li\u1ec1u th\u01b0\u1eddng d\u00f9ng trong \u0111i\u1ec1u tr\u1ecb d\u00e0i h\u1ea1n 1 \u2013 2 vi\u00ean x 1 l\u1ea7n\/ng\u00e0y. Trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p c\u00f3 th\u1ec3 th\u00edch h\u1ee3p v\u1edbi li\u1ec1u cao h\u01a1n, \u0111\u1eb7c bi\u1ec7t trong \u0111i\u1ec1u tr\u1ecb ng\u1eafn h\u1ea1n v\u00e0 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng li\u1ec1u l\u00ean \u0111\u1ebfn 4 vi\u00ean\/ng\u00e0y theo h\u01b0\u1edbng d\u1eabn c\u1ee7a b\u00e1c s\u1ef9.<\/p>\n

4.3. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/strong><\/p>\n

Ng\u01b0\u1eddi m\u1eabn c\u1ea3m v\u1edbi d\u1eabn xu\u1ea5t salicylat v\u00e0 NSAID.<\/p>\n

Ng\u01b0\u1eddi c\u00f3 ti\u1ec1n s\u1eed b\u1ec7nh hen.<\/p>\n

Ng\u01b0\u1eddi lo\u00e9t d\u1ea1 d\u00e0y \u2013 t\u00e1 tr\u00e0ng.<\/p>\n

T\u1ea5t c\u1ea3 c\u00e1c d\u1ea1ng xu\u1ea5t huy\u1ebft do th\u1ec3 t\u1ea1ng hay do m\u1eafc ph\u1ea3i.<\/p>\n

Nguy c\u01a1 xu\u1ea5t huy\u1ebft.<\/p>\n

Ng\u01b0\u1eddi c\u00f3 t\u1ed1c \u0111\u1ed9 l\u1ecdc c\u1ea7u th\u1eadn d\u01b0\u1edbi 30ml\/ph\u00fat v\u00e0 x\u01a1 gan.<\/p>\n

Ng\u01b0\u1eddi m\u1edbi b\u1ecb gout.<\/p>\n

D\u00f9ng li\u1ec1u tr\u00ean 100mg\/ng\u00e0y cho ph\u1ee5 n\u1eef c\u00f3 thai trong 3 th\u00e1ng cu\u1ed1i c\u1ee7a thai k\u1ef3.<\/p>\n

4.4 Th\u1eadn tr\u1ecdng:<\/strong><\/p>\n

Aspirin h\u00e0m l\u01b0\u1ee3ng 81mg kh\u00f4ng ph\u00f9 h\u1ee3p v\u1edbi c\u00e1c ch\u1ec9 \u0111\u1ecbnh h\u1ea1 s\u1ed1t, ch\u1ed1ng vi\u00eam, gi\u1ea3m \u0111au.<\/p>\n

N\u00ean d\u00f9ng cho b\u1ec7nh nh\u00e2n t\u1eeb 16 tu\u1ed5i tr\u1edf l\u00ean. Kh\u00f4ng n\u00ean d\u00f9ng cho b\u1ec7nh nh\u00e2n d\u01b0\u1edbi 16 tu\u1ed5i tr\u1eeb khi l\u1ee3i \u00edch mong \u0111\u1ee3i l\u1edbn h\u01a1n c\u00e1c nguy c\u01a1. Acid acetylsalicylic c\u00f3 th\u1ec3 l\u00e0 y\u1ebfu t\u1ed1 g\u00f3p ph\u1ea7n g\u00e2y ra h\u1ed9i ch\u1ee9ng Reye \u1edf tr\u1ebb em.<\/p>\n

C\u1ea7n th\u1eadn tr\u1ecdng tr\u01b0\u1edbc ph\u1eabu thu\u1eadt, d\u1eebng \u0111i\u1ec1u tr\u1ecb t\u1ea1m th\u1eddi n\u1ebfu c\u1ea7n thi\u1ebft. V\u00ec c\u00f3 th\u1ec3 gia t\u0103ng nguy c\u01a1 ch\u1ea3y m\u00e1u nghi\u00eam tr\u1ecdng trong ho\u1eb7c sau ph\u1eabu thu\u1eadt (th\u1eadm ch\u00ed c\u00e1c ph\u1eabu thu\u1eadt nh\u1ecf nh\u01b0 nh\u1ed5 r\u0103ng).<\/p>\n

Kh\u00f4ng n\u00ean d\u00f9ng trong th\u1eddi k\u1ef3 kinh nguy\u1ec7t v\u00ec c\u00f3 th\u1ec3 l\u00e0m gia t\u0103ng ch\u1ea3y m\u00e1u kinh nguy\u1ec7t.<\/p>\n

C\u1ea7n th\u1eadn tr\u1ecdng trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p huy\u1ebft \u00e1p cao v\u00e0 nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed lo\u00e9t d\u1ea1 d\u00e0y, t\u00e1 tr\u00e0ng, ho\u1eb7c xu\u1ea5t huy\u1ebft ho\u1eb7c \u0111ang \u0111i\u1ec1u tr\u1ecb b\u1eb1ng c\u00e1c li\u1ec7u ph\u00e1p ch\u1ed1ng \u0111\u00f4ng m\u00e1u.
\nN\u00ean b\u00e1o c\u00e1o v\u1edbi b\u00e1c s\u1ef9 b\u1ea5t c\u1ee9 tri\u1ec7u ch\u1ee9ng ch\u1ea3y m\u00e1u b\u1ea5t th\u01b0\u1eddng n\u00e0o. N\u00ean ng\u1eebng \u0111i\u1ec1u tr\u1ecb n\u1ebfu c\u00f3 xu\u1ea5t huy\u1ebft ho\u1eb7c lo\u00e9t \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/p>\n

N\u00ean th\u1eadn tr\u1ecdng khi d\u00f9ng acid acetylsalicylic \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn v\u1eeba ho\u1eb7c ch\u1ee9c n\u0103ng gan suy gi\u1ea3m (ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh n\u1ebfu nghi\u00eam tr\u1ecdng), ho\u1eb7c \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb m\u1ea5t n\u01b0\u1edbc b\u1edfi v\u00ec d\u00f9ng c\u00e1c thu\u1ed1c kh\u00e1ng vi\u00eam kh\u00f4ng steroid (NSAIDs) c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn.<\/p>\n

Acid acetylsalicylic c\u00f3 th\u1ec3 th\u00fac \u0111\u1ea9y c\u00e1c c\u01a1n co th\u1eaft ph\u1ebf qu\u1ea3n v\u00e0 c\u00e1c c\u01a1n hen suy\u1ec5n ho\u1eb7c c\u00e1c ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn kh\u00e1c. Y\u1ebfu t\u1ed1 nguy c\u01a1 l\u00e0 b\u1ec7nh hen suy\u1ec5n, vi\u00eam m\u0169i d\u1ecb \u1ee9ng, polyp m\u0169i ho\u1eb7c b\u1ec7nh h\u00f4 h\u1ea5p m\u00e3n t\u00ednh, ng\u01b0\u1eddi c\u00f3 ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng v\u1edbi c\u00e1c ch\u1ea5t kh\u00e1c (v\u00ed d\u1ee5: Ph\u1ea3n \u1ee9ng da, m\u1eabn ng\u1ee9a ho\u1eb7c m\u00e0y \u0111ay).<\/p>\n

C\u00e1c ph\u1ea3n \u1ee9ng ph\u1ee5 tr\u00ean da nghi\u00eam tr\u1ecdng, bao g\u1ed3m h\u1ed9i ch\u1ee9ng Steven-Johnsons, \u00edt khi \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o c\u00f3 li\u00ean quan \u0111\u1ebfn vi\u1ec7c d\u00f9ng acid acetylsalicylic. N\u00ean d\u1eebng ngay vi\u1ec7c d\u00f9ng thu\u1ed1c khi l\u1ea7n \u0111\u1ea7u ti\u00ean xu\u1ea5t hi\u1ec7n ph\u00e1t ban da, t\u1ed5n th\u01b0\u01a1ng ni\u00eam m\u1ea1c, ho\u1eb7c b\u1ea5t k\u1ef3 d\u1ea5u hi\u1ec7u n\u00e0o c\u1ee7a ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn.<\/p>\n

B\u1ec7nh nh\u00e2n l\u1edbn tu\u1ed5i \u0111\u1eb7c bi\u1ec7t nh\u1ea1y c\u1ea3m v\u1edbi t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a c\u00e1c thu\u1ed1c kh\u00e1ng vi\u00eam kh\u00f4ng steroid (NSAIDs), bao g\u1ed3m acid acetylsalicylic, \u0111\u1eb7c bi\u1ec7t l\u00e0 xu\u1ea5t huy\u1ebft ti\u00eau h\u00f3a v\u00e0 th\u1ee7ng \u0111\u01b0\u1eddng ti\u00eau h\u00f3a c\u00f3 th\u1ec3 g\u00e2y t\u1eed vong. Tr\u01b0\u1eddng h\u1ee3p \u0111i\u1ec1u tr\u1ecb k\u00e9o d\u00e0i, b\u1ec7nh nh\u00e2n n\u00ean \u0111\u01b0\u1ee3c xem x\u00e9t th\u01b0\u1eddng xuy\u00ean.<\/p>\n

Kh\u00f4ng n\u00ean \u0111i\u1ec1u tr\u1ecb \u0111\u1ed3ng th\u1eddi Aspirin 81 v\u1edbi c\u00e1c thu\u1ed1c l\u00e0m thay \u0111\u1ed5i qu\u00e1 tr\u00ecnh \u0111\u00f4ng m\u00e1u (v\u00ed d\u1ee5: C\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u nh\u01b0 warfarin, thu\u1ed1c ch\u1ed1ng c\u1ee5c m\u00e1u \u0111\u00f4ng v\u00e0 thu\u1ed1c ch\u1ed1ng k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u, thu\u1ed1c kh\u00e1ng vi\u00eam v\u00e0 c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc t\u00e1i h\u1ea5p thu serotonin), tr\u1eeb khi \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh r\u00f5, v\u00ec c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 xu\u1ea5t huy\u1ebft. N\u1ebfu vi\u1ec7c k\u1ebft h\u1ee3p l\u00e0 b\u1eaft bu\u1ed9c, n\u00ean theo d\u00f5i ch\u1eb7t ch\u1ebd c\u00e1c d\u1ea5u hi\u1ec7u xu\u1ea5t huy\u1ebft.<\/p>\n

N\u00ean th\u1eadn tr\u1ecdng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng c\u00e1c thu\u1ed1c kh\u00e1c c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 lo\u00e9t, nh\u01b0 c\u00e1c corticoid d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng, c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc t\u00e1i h\u1ea5p thu serotonin v\u00e0 c\u00e1c ph\u1ee9c h\u1ee3p c\u1ee7a s\u1eaft d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng.<\/p>\n

C\u1ea7n tr\u00e1nh d\u00f9ng acid acetylsalicylic \u1edf cu\u1ed1i thai k\u1ef3 v\u00e0 th\u00f4ng th\u01b0\u1eddng trong th\u1eddi gian cho con b\u00fa.<\/p>\n

D\u00f9ng Aspirin li\u1ec1u th\u1ea5p l\u00e0m gi\u1ea3m b\u00e0i ti\u1ebft acid uric. Do \u0111\u00f3, nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 xu h\u01b0\u1edbng gi\u1ea3m b\u00e0i ti\u1ebft acid uric c\u00f3 th\u1ec3 b\u1ecb c\u00e1c c\u01a1n gout c\u1ea5p.<\/p>\n

D\u00f9ng Apirin 81 qu\u00e1 li\u1ec1u c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft c\u1ee7a c\u00e1c thu\u1ed1c h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft nh\u00f3m sulfonylur\u00ea v\u00e0 insulin.<\/p>\n

Th\u00e0nh ph\u1ea7n t\u00e1 d\u01b0\u1ee3c c\u1ee7a thu\u1ed1c n\u00e0y c\u00f3:<\/p>\n

M\u00e0u tartrazin (E 102): C\u00f3 th\u1ec3 g\u00e2y ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng.<\/p>\n

Tinh b\u1ed9t m\u00ec: Kh\u00f4ng n\u00ean d\u00f9ng thu\u1ed1c n\u00e0y cho b\u1ec7nh nh\u00e2n b\u1ecb d\u1ecb \u1ee9ng v\u1edbi l\u00faa m\u00ec (kh\u00e1c v\u1edbi b\u1ec7nh Celiac).<\/p>\n

T\u00e1c \u0111\u1ed9ng c\u1ee7a thu\u1ed1c tr\u00ean ng\u01b0\u1eddi l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/strong><\/p>\n

L\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c: thu\u1ed1c n\u00e0y kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng l\u00e1i xe v\u00e0 v\u1eadn h\u00e0nh m\u00e1y m\u00f3c.<\/p>\n

4.5 S\u1eed d\u1ee5ng cho ph\u1ee5 n\u1eef c\u00f3 thai v\u00e0 cho con b\u00fa:<\/strong><\/p>\n

X\u1ebfp h\u1ea1ng c\u1ea3nh b\u00e1o<\/em><\/p>\n

AU TGA pregnancy category: C<\/p>\n

US FDA pregnancy category: NA<\/p>\n

Th\u1eddi k\u1ef3 mang thai:<\/em><\/p>\n

Li\u1ec1u th\u1ea5p (l\u00ean \u0111\u1ebfn 100mg\/ng\u00e0y): C\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng ch\u1ec9 ra r\u1eb1ng li\u1ec1u d\u00f9ng l\u00ean \u0111\u1ebfn 100mg\/ng\u00e0y h\u1ea1n ch\u1ebf d\u00f9ng trong s\u1ea3n khoa, v\u00ec y\u00eau c\u1ea7u gi\u00e1m s\u00e1t chuy\u00ean m\u00f4n, cho th\u1ea5y an to\u00e0n.<\/p>\n

Li\u1ec1u 100 \u2013 500mg\/ng\u00e0y: C\u00f3 \u00edt th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng li\u00ean quan \u0111\u1ebfn vi\u1ec7c d\u00f9ng li\u1ec1u tr\u00ean 100mg\/ng\u00e0y \u0111\u1ebfn 500mg\/ng\u00e0y. Do \u0111\u00f3, c\u00e1c khuy\u1ebfn c\u00e1o \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng c\u00f9ng v\u1edbi m\u1ee9c li\u1ec1u t\u1eeb 500mg\/ng\u00e0y tr\u1edf l\u00ean.<\/p>\n

Li\u1ec1u t\u1eeb 500mg\/ng\u00e0y tr\u1edf l\u00ean:<\/p>\n

T\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p prostaglandin c\u00f3 th\u1ec3 g\u00e2y \u1ea3nh h\u01b0\u1edfng x\u1ea5u \u0111\u1ebfn thai k\u1ef3 v\u00e0\/ho\u1eb7c s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a ph\u00f4i thai\/b\u00e0o thai. D\u1eef li\u1ec7u t\u1eeb c\u00e1c nghi\u00ean c\u1ee9u d\u1ecbch t\u1ec5 h\u1ecdc cho th\u1ea5y nguy c\u01a1 s\u1ea9y thai v\u00e0 khuy\u1ebft t\u1eadt tim v\u00e0 th\u00e0nh b\u1ee5ng t\u0103ng l\u00ean sau khi d\u00f9ng c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p prostaglandin trong giai \u0111o\u1ea1n \u0111\u1ea7u c\u1ee7a thai k\u1ef3. T\u1ec9 l\u1ec7 ch\u1eafc ch\u1eafn x\u1ea3y ra c\u1ee7a khuy\u1ebft t\u1eadt tim m\u1ea1ch t\u0103ng t\u1eeb d\u01b0\u1edbi 1% l\u00ean \u0111\u1ebfn x\u1ea5p x\u1ec9 1, 5%. Nguy c\u01a1 n\u00e0y \u0111\u01b0\u1ee3c cho l\u00e0 t\u0103ng theo li\u1ec1u v\u00e0 th\u1eddi gian \u0111i\u1ec1u tr\u1ecb. Tr\u00ean \u0111\u1ed9ng v\u1eadt, vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p prostaglandin l\u00e0m s\u1ef1 m\u1ea5t v\u00e0 ch\u1ebft ph\u00f4i thai t\u0103ng l\u00ean tr\u01b0\u1edbc v\u00e0 sau khi c\u1ea5y. Ngo\u00e0i ra, nguy c\u01a1 m\u1eafc c\u00e1c d\u1ecb d\u1ea1ng kh\u00e1c, bao g\u1ed3m d\u1ecb d\u1ea1ng tim m\u1ea1ch, t\u0103ng l\u00ean, \u0111\u00e3 \u0111\u01b0\u1ee3c ghi nh\u1eadn \u1edf \u0111\u1ed9ng v\u1eadt \u0111\u01b0\u1ee3c cho d\u00f9ng ch\u1ea5t \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p prostaglandin trong giai \u0111o\u1ea1n h\u00ecnh th\u00e0nh c\u00e1c c\u01a1 quan. Trong tam c\u00e1 nguy\u1ec7t th\u1ee9 nh\u1ea5t v\u00e0 th\u1ee9 hai c\u1ee7a thai k\u1ef3, kh\u00f4ng n\u00ean d\u00f9ng acid acetylsalicylic, tr\u1eeb khi th\u1eadt s\u1ef1 c\u1ea7n thi\u1ebft. N\u1ebfu d\u00f9ng acid acetylsalicylic \u1edf ph\u1ee5 n\u1eef c\u1ed1 g\u1eafng th\u1ee5 thai, ho\u1eb7c trong tam c\u00e1 nguy\u1ec7t th\u1ee9 nh\u1ea5t v\u00e0 th\u1ee9 hai c\u1ee7a thai k\u1ef3, n\u00ean d\u00f9ng li\u1ec1u th\u1ea5p v\u00e0 th\u1eddi gian d\u00f9ng n\u00ean ng\u1eafn nh\u1ea5t c\u00f3 th\u1ec3.<\/p>\n

Trong tam c\u00e1 nguy\u1ec7t th\u1ee9 ba c\u1ee7a thai k\u1ef3, t\u1ea5t c\u1ea3 c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p prostaglandin c\u00f3 th\u1ec3 khi\u1ebfn cho thai nhi:<\/p>\n

\u0110\u1ed9c t\u00ednh tim ph\u1ed5i (v\u1edbi s\u1ef1 \u0111\u00f3ng s\u1edbm c\u1ee7a \u1ed1ng \u0111\u1ed9ng m\u1ea1ch v\u00e0 t\u0103ng huy\u1ebft \u00e1p ph\u1ed5i).<\/p>\n

R\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng th\u1eadn, c\u00f3 th\u1ec3 ti\u1ebfn tri\u1ec3n \u0111\u1ebfn suy th\u1eadn k\u00e8m thi\u1ec3u \u1ed1i.<\/p>\n

Khi\u1ebfn cho ng\u01b0\u1eddi m\u1eb9 v\u00e0 tr\u1ebb s\u01a1 sinh \u1edf cu\u1ed1i thai k\u1ef3:<\/p>\n

C\u00f3 th\u1ec3 k\u00e9o d\u00e0i th\u1eddi gian xu\u1ea5t huy\u1ebft, do t\u00e1c \u0111\u1ed9ng ch\u1ed1ng k\u1ebft t\u1eadp c\u00f3 th\u1ec3 x\u1ea3y ra \u1edf li\u1ec1u r\u1ea5t th\u1ea5p.<\/p>\n

\u1ee8c ch\u1ebf c\u01a1n co t\u1eed cung d\u1eabn \u0111\u1ebfn tr\u00ec ho\u00e3n ho\u1eb7c k\u00e9o d\u00e0i s\u1ef1 chuy\u1ec3n d\u1ea1.<\/p>\n

Do \u0111\u00f3, acid acetylsalicylic \u1edf li\u1ec1u 100mg\/ng\u00e0y ho\u1eb7c cao h\u01a1n l\u00e0 ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh trong tam c\u00e1 nguy\u1ec7t th\u1ee9 ba c\u1ee7a thai k\u1ef3.<\/p>\n

Th\u1eddi k\u1ef3 cho con b\u00fa:<\/em><\/p>\n

L\u01b0\u1ee3ng \u00edt salicylat v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a c\u1ee7a n\u00f3 \u0111\u01b0\u1ee3c b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9. V\u00ec c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean tr\u1ebb s\u01a1 sinh \u0111\u1ebfn nay v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o, do \u0111\u00f3 s\u1eed d\u1ee5ng thu\u1ed1c v\u1edbi li\u1ec1u khuy\u1ebfn c\u00e1o trong th\u1eddi gian ng\u1eafn kh\u00f4ng c\u1ea7n ph\u1ea3i ng\u1eebng cho con b\u00fa.<\/p>\n

4.6 T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n (ADR):<\/strong><\/p>\n

Th\u01b0\u1eddng g\u1eb7p, ADR >1\/100<\/em><\/p>\n

Ti\u00eau h\u00f3a: Bu\u1ed3n n\u00f4n, n\u00f4n, kh\u00f3 ti\u00eau, kh\u00f3 ch\u1ecbu \u1edf th\u01b0\u1ee3ng v\u1ecb, \u1ee3 n\u00f3ng, \u0111au d\u1ea1 d\u00e0y, lo\u00e9t d\u1ea1 d\u00e0y \u2013 ru\u1ed9t.<\/p>\n

H\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng: M\u1ec7t m\u1ecfi.<\/p>\n

Da: Ban, m\u00e0y \u0111ay.<\/p>\n

Huy\u1ebft h\u1ecdc: Thi\u1ebfu m\u00e1u tan m\u00e1u.<\/p>\n

Th\u1ea7n kinh \u2013 c\u01a1 v\u00e0 x\u01b0\u01a1ng: Y\u1ebfu c\u01a1.<\/p>\n

H\u00f4 h\u1ea5p: Kh\u00f3 th\u1edf.<\/p>\n

Kh\u00e1c: S\u1ed1c ph\u1ea3n v\u1ec7.<\/p>\n

\u00cdt g\u1eb7p, 1\/1000 < ADR <1\/100<\/em><\/p>\n

H\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng: M\u1ea5t ng\u1ee7, b\u1ed3n ch\u1ed3n, c\u00e1u g\u1eaft.<\/p>\n

N\u1ed9i ti\u1ebft v\u00e0 chuy\u1ec3n h\u00f3a: Thi\u1ebfu s\u1eaft.<\/p>\n

Huy\u1ebft h\u1ecdc: Ch\u1ea3y m\u00e1u \u1ea9n, th\u1eddi gian ch\u1ea3y m\u00e1u k\u00e9o d\u00e0i, gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m ti\u1ec3u c\u1ea7u, thi\u1ebfu m\u00e1u.<\/p>\n

Gan: \u0110\u1ed9c h\u1ea1i gan.<\/p>\n

Th\u1eadn: Suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn.<\/p>\n

H\u00f4 h\u1ea5p: Co th\u1eaft ph\u1ebf qu\u1ea3n.<\/p>\n

Th\u00f4ng b\u00e1o cho B\u00e1c s\u0129 nh\u1eefng t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed d\u1ee5ng thu\u1ed1c.<\/em><\/p>\n

4.7 H\u01b0\u1edbng d\u1eabn c\u00e1ch x\u1eed tr\u00ed ADR:<\/strong><\/p>\n

ADR tr\u00ean h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng c\u00f3 th\u1ec3 h\u1ed3i ph\u1ee5c ho\u00e0n to\u00e0n trong v\u00f2ng 2 \u2013 3 ng\u00e0y sau khi ng\u1eebng thu\u1ed1c. N\u1ebfu c\u00f3 c\u00e1c tri\u1ec7u ch\u1ee9ng ch\u00f3ng m\u1eb7t, \u00f9 tai, gi\u1ea3m th\u00ednh l\u1ef1c ho\u1eb7c th\u01b0\u01a1ng t\u1ed5n gan, ph\u1ea3i ng\u1eebng thu\u1ed1c. \u1ede ng\u01b0\u1eddi cao tu\u1ed5i, n\u00ean \u0111i\u1ec1u tr\u1ecb v\u1edbi li\u1ec1u aspirin th\u1ea5p nh\u1ea5t c\u00f3 hi\u1ec7u l\u1ef1c v\u00e0 trong th\u1eddi gian ng\u1eafn nh\u1ea5t c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c. \u0110i\u1ec1u tr\u1ecb s\u1ed1c ph\u1ea3n v\u1ec7 do aspirin v\u1edbi li\u1ec7u ph\u00e1p gi\u1ed1ng nh\u01b0 khi \u0111i\u1ec1u tr\u1ecb c\u00e1c ph\u1ea3n \u1ee9ng ph\u1ea3n v\u1ec7 c\u1ea5p t\u00ednh. Adrenalin l\u00e0 thu\u1ed1c ch\u1ecdn l\u1ecdc v\u00e0 th\u01b0\u1eddng ki\u1ec3m so\u00e1t d\u1ec5 d\u00e0ng ch\u1ee9ng ph\u00f9 m\u1ea1ch v\u00e0 m\u00e0y \u0111ay<\/p>\n

4.8 T\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c:<\/strong><\/p>\n

T\u01b0\u01a1ng t\u00e1c ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh:<\/em><\/strong><\/p>\n

Methotrexat (li\u1ec1u > 15mg\/tu\u1ea7n): S\u1ef1 k\u1ebft h\u1ee3p methotrexat v\u00e0 acid acetylsalicylic l\u00e0m t\u0103ng \u0111\u1ed9c t\u00ednh huy\u1ebft h\u1ecdc c\u1ee7a methotrexat do gi\u1ea3m \u0111\u1ed9 thanh th\u1ea3i c\u1ea7u th\u1eadn c\u1ee7a methotrexat b\u1edfi acid acetylsalicylic. Do \u0111\u00f3, kh\u00f4ng d\u00f9ng \u0111\u1ed3ng th\u1eddi methotrexat (li\u1ec1u > 15mg\/tu\u1ea7n) v\u1edbi Aspirin.<\/p>\n

T\u01b0\u01a1ng t\u00e1c n\u00ean tr\u00e1nh:<\/em><\/strong><\/p>\n

C\u00e1c thu\u1ed1c t\u0103ng b\u00e0i ti\u1ebft acid uric trong n\u01b0\u1edbc ti\u1ec3u, v\u00ed d\u1ee5: Probenecid<\/p>\n

Salicylat l\u00e0m \u0111\u1ea3o ng\u01b0\u1ee3c t\u00e1c d\u1ee5ng c\u1ee7a probenecid, tr\u00e1nh d\u00f9ng ph\u1ed1i h\u1ee3p.<\/p>\n

T\u01b0\u01a1ng t\u00e1c ph\u1ea3i th\u1eadn tr\u1ecdng ho\u1eb7c xem x\u00e9t k\u1ef9 khi d\u00f9ng:<\/em><\/strong><\/p>\n

C\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u, v\u00ed d\u1ee5: Coumarin, heparin, warfarin: L\u00e0m t\u0103ng nguy c\u01a1 xu\u1ea5t huy\u1ebft do \u1ee9c ch\u1ebf ch\u1ee9c n\u0103ng ti\u1ec3u c\u1ea7u, l\u00e0m t\u1ed5n th\u01b0\u01a1ng ni\u00eam m\u1ea1c t\u00e1 tr\u00e0ng v\u00e0 thay \u0111\u1ed5i v\u1ecb tr\u00ed g\u1eafn k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng c\u1ee7a c\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u. Th\u1eddi gian ch\u1ea3y m\u00e1u n\u00ean \u0111\u01b0\u1ee3c theo d\u00f5i.<\/p>\n

C\u00e1c thu\u1ed1c ch\u1ed1ng k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u (v\u00ed d\u1ee5: Clopidogrel v\u00e0 dipyridamol) v\u00e0 c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc t\u00e1i h\u1ea5p thu serotonin (v\u00ed d\u1ee5: Sertralin ho\u1eb7c paroxetin): T\u0103ng nguy c\u01a1 xu\u1ea5t huy\u1ebft \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/p>\n

C\u00e1c thu\u1ed1c ch\u1ed1ng \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng (v\u00ed d\u1ee5: Sulfonylur\u00ea): Salicylic c\u00f3 th\u1ec3 l\u00e0m t\u0103ng t\u00e1c d\u1ee5ng h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft c\u1ee7a sulfonylur\u00ea.<\/p>\n

Digoxin v\u00e0 lithi: Acid acetylsalicylic l\u00e0m gi\u1ea3m b\u00e0i ti\u1ebft digoxin v\u00e0 lithi, d\u1eabn \u0111\u1ebfn t\u0103ng n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng. N\u00ean theo d\u00f5i n\u1ed3ng \u0111\u1ed9 digoxin v\u00e0 lithi trong huy\u1ebft t\u01b0\u01a1ng khi b\u1eaft \u0111\u1ea7u v\u00e0 khi k\u1ebft th\u00fac \u0111i\u1ec1u tr\u1ecb b\u1eb1ng acid acetylsalicylic. \u0110i\u1ec1u ch\u1ec9nh li\u1ec1u n\u1ebfu c\u1ea7n thi\u1ebft.<\/p>\n

C\u00e1c thu\u1ed1c l\u1ee3i ti\u1ec3u v\u00e0 ch\u1ed1ng t\u0103ng huy\u1ebft \u00e1p: C\u00e1c thu\u1ed1c kh\u00e1ng vi\u00eam kh\u00f4ng steroid (NSAIDs) c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng ch\u1ed1ng t\u0103ng huy\u1ebft \u00e1p c\u1ee7a thu\u1ed1c l\u1ee3i ti\u1ec3u v\u00e0 c\u00e1c thu\u1ed1c ch\u1ed1ng t\u0103ng huy\u1ebft \u00e1p kh\u00e1c. Khi k\u1ebft h\u1ee3p c\u00e1c thu\u1ed1c kh\u00e1ng vi\u00eam kh\u00f4ng steroid (NSAIDs) kh\u00e1c v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n l\u00e0m t\u0103ng nguy c\u01a1 suy th\u1eadn c\u1ea5p. Nguy c\u01a1 suy th\u1eadn c\u1ea5p do gi\u1ea3m \u0111\u1ed9 l\u1ecdc c\u1ea7u th\u1eadn th\u00f4ng qua gi\u1ea3m t\u1ed5ng h\u1ee3p prostaglandin th\u1eadn. N\u00ean b\u1ed5 sung n\u01b0\u1edbc cho b\u1ec7nh nh\u00e2n v\u00e0 theo d\u00f5i ch\u1ee9c n\u0103ng th\u1eadn t\u1ea1i th\u1eddi \u0111i\u1ec3m b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb.<\/p>\n

C\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf carbonic anhydrase (v\u00ed d\u1ee5: Acetazolamid): C\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn nhi\u1ec5m toan nghi\u00eam tr\u1ecdng v\u00e0 t\u0103ng nhi\u1ec5m \u0111\u1ed9c h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng.<\/p>\n

C\u00e1c glucocorticoid: T\u0103ng nguy c\u01a1 lo\u00e9t v\u00e0 xu\u1ea5t huy\u1ebft \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/p>\n

Methotrexat (li\u1ec1u < 15mg\/tu\u1ea7n): S\u1ef1 k\u1ebft h\u1ee3p methotrexat v\u00e0 acid acetylsalicylic l\u00e0m t\u0103ng \u0111\u1ed9c t\u00ednh huy\u1ebft h\u1ecdc c\u1ee7a methotrexat do gi\u1ea3m \u0111\u1ed9 thanh th\u1ea3i c\u1ea7u th\u1eadn c\u1ee7a methotrexat b\u1edfi acid acetylsalicylic. N\u00ean ki\u1ec3m tra c\u00f4ng th\u1ee9c m\u00e1u h\u00e0ng tu\u1ea7n trong su\u1ed1t nh\u1eefng tu\u1ea7n \u0111\u1ea7u ti\u00ean. T\u0103ng c\u01b0\u1eddng theo d\u00f5i \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn nh\u1eb9 v\u00e0 ng\u01b0\u1eddi cao tu\u1ed5i.<\/p>\n

C\u00e1c thu\u1ed1c kh\u00e1ng vi\u00eam kh\u00f4ng steroid (NSAIDs) kh\u00e1c: T\u0103ng nguy c\u01a1 xu\u1ea5t huy\u1ebft v\u00e0 lo\u00e9t \u0111\u01b0\u1eddng ti\u00eau h\u00f3a t\u00e1c d\u1ee5ng hi\u1ec7p \u0111\u1ed3ng.<\/p>\n

Ibuprofen: D\u1eef li\u1ec7u th\u1ef1c nghi\u1ec7m cho th\u1ea5y ibuprofen c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf t\u00e1c d\u1ee5ng ch\u1ed1ng k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u c\u1ee7a aspirin li\u1ec1u th\u1ea5p khi d\u00f9ng chung.<\/p>\n

Ciclosporin, tacrolimus: T\u0103ng \u0111\u1ed9c t\u00ednh \u1edf th\u1eadn c\u1ee7a ciclosporin v\u00e0 tacrolimus. N\u00ean theo d\u00f5i ch\u1ee9c n\u0103ng th\u1eadn khi k\u1ebft h\u1ee3p.<\/p>\n

C\u00e1c antacid: T\u0103ng b\u00e0i ti\u1ebft acid acetylsalicylic do t\u00e1c d\u1ee5ng ki\u1ec1m h\u00f3a n\u01b0\u1edbc ti\u1ec3u c\u1ee7a antacid.<\/p>\n

R\u01b0\u1ee3u: D\u00f9ng \u0111\u1ed3ng th\u1eddi r\u01b0\u1ee3u v\u00e0 acid acetylsalicylic l\u00e0m t\u0103ng nguy c\u01a1 xu\u1ea5t huy\u1ebft \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/p>\n

4.9 Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed:<\/strong><\/p>\n

Qu\u00e1 li\u1ec1u:\u00a0<\/em>Khi u\u1ed1ng m\u1ed9t l\u01b0\u1ee3ng l\u1edbn acid acetylsalicylic c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn th\u1edf s\u00e2u, nhanh, \u00f9 tai, \u0111i\u1ebfc, gi\u00e3n m\u1ea1ch, ra m\u1ed3 h\u00f4i.<\/p>\n

C\u00e1ch x\u1eed tr\u00ed:<\/em><\/p>\n

L\u00e0m s\u1ea1ch d\u1ea1 d\u00e0y b\u1eb1ng c\u00e1ch g\u00e2y n\u00f4n (ch\u00fa \u00fd c\u1ea9n th\u1eadn \u0111\u1ec3 kh\u00f4ng h\u00edt v\u00e0o) ho\u1eb7c r\u1eeda d\u1ea1 d\u00e0y, cho u\u1ed1ng than ho\u1ea1t. Theo d\u00f5i v\u00e0 n\u00e2ng \u0111\u1ee1 c\u00e1c ch\u1ee9c n\u0103ng c\u1ea7n thi\u1ebft cho s\u1ef1 s\u1ed1ng. \u0110i\u1ec1u tr\u1ecb s\u1ed1t cao; truy\u1ec1n d\u1ecbch, ch\u1ea5t \u0111i\u1ec7n gi\u1ea3i, hi\u1ec7u ch\u1ec9nh m\u1ea5t c\u00e2n b\u1eb1ng acid \u2013 base; \u0111i\u1ec1u tr\u1ecb ch\u1ee9ng t\u00edch ceton; gi\u1eef n\u1ed3ng \u0111\u1ed9 Glucose huy\u1ebft t\u01b0\u01a1ng th\u00edch h\u1ee3p.<\/p>\n

G\u00e2y b\u00e0i ni\u1ec7u b\u1eb1ng c\u00e1ch ki\u1ec1m h\u00f3a n\u01b0\u1edbc ti\u1ec3u \u0111\u1ec3 t\u0103ng th\u1ea3i tr\u1eeb salicylat.<\/p>\n

Th\u1ef1c hi\u1ec7n truy\u1ec1n thay m\u00e1u, th\u1ea9m t\u00e1ch m\u00e1u, th\u1ea9m t\u00e1ch ph\u00fac m\u1ea1c, n\u1ebfu c\u1ea7n khi qu\u00e1 li\u1ec1u nghi\u00eam tr\u1ecdng.<\/p>\n

Theo d\u00f5i ph\u00f9 ph\u1ed5i, co gi\u1eadt v\u00e0 th\u1ef1c hi\u1ec7n li\u1ec7u ph\u00e1p th\u00edch h\u1ee3p n\u1ebfu c\u1ea7n.<\/p>\n

Truy\u1ec1n m\u00e1u ho\u1eb7c d\u00f9ng Vitamin K n\u1ebfu c\u1ea7n \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ch\u1ea3y m\u00e1u.<\/p>\n

5. C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c :<\/strong><\/p>\n

5.1. D\u01b0\u1ee3c l\u1ef1c h\u1ecdc:<\/strong><\/p>\n

Acid acetylsalicylic \u1ee9c ch\u1ebf kh\u00f4ng thu\u1eadn ngh\u1ecbch cyclooxygenase, do \u0111\u00f3 \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p prostaglandin. C\u00e1c t\u1ebf b\u00e0o c\u00f3 kh\u1ea3 n\u0103ng t\u1ed5ng h\u1ee3p cyclooxygenase m\u1edbi s\u1ebd c\u00f3 th\u1ec3 ti\u1ebfp t\u1ee5c t\u1ed5ng h\u1ee3p prostaglandin sau khi n\u1ed3ng \u0111\u1ed9 acid salicylic gi\u1ea3m. Ti\u1ec3u c\u1ea7u l\u00e0 t\u1ebf b\u00e0o kh\u00f4ng c\u00f3 nh\u00e2n, kh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng t\u1ed5ng h\u1ee3p cyclooxygenase m\u1edbi, do \u0111\u00f3 cyclooxygenase b\u1ecb \u1ee9c ch\u1ebf kh\u00f4ng thu\u1eadn ngh\u1ecbch, cho t\u1edbi khi ti\u1ec3u c\u1ea7u m\u1edbi \u0111\u01b0\u1ee3c t\u1ea1o th\u00e0nh. Nh\u01b0 v\u1eady, acid acetylsalicylic \u1ee9c ch\u1ebf kh\u00f4ng thu\u1eadn ngh\u1ecbch k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u, cho t\u1edbi khi ti\u1ec3u c\u1ea7u m\u1edbi \u0111\u01b0\u1ee3c t\u1ea1o th\u00e0nh.<\/p>\n

Acid acetylsalicylic c\u00f2n \u1ee9c ch\u1ebf s\u1ea3n sinh prostaglandin \u1edf th\u1eadn. S\u1ef1 s\u1ea3n sinh prostaglandin \u1edf th\u1eadn \u00edt quan tr\u1ecdng v\u1ec1 m\u1eb7t sinh l\u00fd v\u1edbi ng\u01b0\u1eddi b\u1ec7nh c\u00f3 th\u1eadn b\u00ecnh th\u01b0\u1eddng, nh\u01b0ng c\u00f3 vai tr\u00f2 r\u1ea5t quan tr\u1ecdng trong duy tr\u00ec l\u01b0u th\u00f4ng m\u00e1u qua th\u1eadn \u1edf ng\u01b0\u1eddi suy th\u1eadn m\u00e3n t\u00ednh, suy tim, suy gan ho\u1eb7c c\u00f3 r\u1ed1i lo\u1ea1n v\u1ec1 th\u1ec3 t\u00edch huy\u1ebft t\u01b0\u01a1ng. \u1ede nh\u1eefng ng\u01b0\u1eddi b\u1ec7nh n\u00e0y, t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p prostaglandin \u1edf th\u1eadn c\u1ee7a acid acetylsalicylic c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn suy th\u1eadn c\u1ea5p t\u00ednh, gi\u1eef n\u01b0\u1edbc v\u00e0 suy tim c\u1ea5p t\u00ednh.<\/p>\n

C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng: <\/em><\/strong><\/p>\n

Aspirin \u1ee9c ch\u1ebf kh\u00f4ng thu\u1eadn ngh\u1ecbch cyclooxygenase, do \u0111\u00f3 \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p prostaglandin. C\u00e1c t\u1ebf b\u00e0o c\u00f3 kh\u1ea3 n\u0103ng t\u1ed5ng h\u1ee3p cyclooxygenase m\u1edbi s\u1ebd c\u00f3 th\u1ec3 ti\u1ebfp t\u1ee5c t\u1ed5ng h\u1ee3p prostaglandin, sau khi n\u1ed3ng \u0111\u1ed9 acid salicylic gi\u1ea3m. Ti\u1ec3u c\u1ea7u l\u00e0 t\u1ebf b\u00e0o kh\u00f4ng c\u00f3 nh\u00e2n, kh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng t\u1ed5ng h\u1ee3p cyclooxygenase m\u1edbi, do \u0111\u00f3 cyclooxygenase b\u1ecb \u1ee9c ch\u1ebf kh\u00f4ng thu\u1eadn ngh\u1ecbch, cho t\u1edbi khi ti\u1ec3u c\u1ea7u m\u1edbi \u0111\u01b0\u1ee3c t\u1ea1o th\u00e0nh. Nh\u01b0 v\u1eady aspirin \u1ee9c ch\u1ebf kh\u00f4ng thu\u1eadn ngh\u1ecbch k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u, cho t\u1edbi khi ti\u1ec3u c\u1ea7u m\u1edbi \u0111\u01b0\u1ee3c t\u1ea1o th\u00e0nh.<\/p>\n

Aspirin c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u. C\u01a1 ch\u1ebf do \u1ee9c ch\u1ebf COX c\u1ee7a ti\u1ec3u c\u1ea7u d\u1eabn \u0111\u1ebfn \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p thromboxan A2<\/sub> l\u00e0 ch\u1ea5t g\u00e2y k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u.<\/p>\n

[XEM T\u1ea0I \u0110\u00c2Y]<\/strong><\/p>\n

5.2. D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc:<\/strong><\/p>\n

Acid acetylsalicylic khi u\u1ed1ng \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh v\u1edbi m\u1ee9c \u0111\u1ed9 cao. Trong khi \u0111\u01b0\u1ee3c h\u1ea5p thu qua th\u00e0nh ru\u1ed9t, c\u0169ng nh\u01b0 khi \u1edf gan v\u00e0 m\u00e1u, acid acetylsalicylic \u0111\u01b0\u1ee3c th\u1ee7y ph\u00e2n th\u00e0nh acid salicylic, c\u00f3 c\u00f9ng t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd nh\u01b0 acid acetylsalicylic.<\/p>\n

Kh\u1ea3 d\u1ee5ng sinh h\u1ecdc u\u1ed1ng: 68% \u00b1 3.<\/p>\n

G\u1eafn v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng: 49%. T\u0103ng ur\u00ea m\u00e1u l\u00e0m gi\u1ea3m g\u1eafn v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng.<\/p>\n

\u0110\u1ed9 thanh th\u1ea3i: 9, 3 ml\/ph\u00fat\/kg \u00b1 1, 1. \u0110\u1ed9 thanh th\u1ea3i thay \u0111\u1ed5i \u1edf ng\u01b0\u1eddi cao tu\u1ed5i v\u00e0 ng\u01b0\u1eddi x\u01a1 gan.<\/p>\n

Th\u1eddi gian b\u00e1n th\u1ea3i: 0, 25 gi\u1edd \u00b1 0, 03. Th\u1eddi gian b\u00e1n th\u1ea3i thay \u0111\u1ed5i \u1edf ng\u01b0\u1eddi vi\u00eam gan.<\/p>\n

\u0110\u00e0o th\u1ea3i qua th\u1eadn ch\u1ee7 y\u1ebfu d\u01b0\u1edbi d\u1ea1ng acid salicylic t\u1ef1 do v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a li\u00ean h\u1ee3p.Acid acetylsalicylic khi u\u1ed1ng \u0111\u01b0\u1ee3c h\u1ea5p thu nhanh v\u1edbi m\u1ee9c \u0111\u1ed9 cao. Trong khi \u0111\u01b0\u1ee3c h\u1ea5p thu qua th\u00e0nh ru\u1ed9t, c\u0169ng nh\u01b0 khi \u1edf gan v\u00e0 m\u00e1u, acid acetylsalicylic \u0111\u01b0\u1ee3c th\u1ee7y ph\u00e2n th\u00e0nh acid salicylic, c\u00f3 c\u00f9ng t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd nh\u01b0 acid acetylsalicylic.<\/p>\n

Kh\u1ea3 d\u1ee5ng sinh h\u1ecdc u\u1ed1ng: 68% \u00b1 3.<\/p>\n

G\u1eafn v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng: 49%. T\u0103ng ur\u00ea m\u00e1u l\u00e0m gi\u1ea3m g\u1eafn v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng.<\/p>\n

\u0110\u1ed9 thanh th\u1ea3i: 9, 3 ml\/ph\u00fat\/kg \u00b1 1, 1. \u0110\u1ed9 thanh th\u1ea3i thay \u0111\u1ed5i \u1edf ng\u01b0\u1eddi cao tu\u1ed5i v\u00e0 ng\u01b0\u1eddi x\u01a1 gan.<\/p>\n

Th\u1eddi gian b\u00e1n th\u1ea3i: 0, 25 gi\u1edd \u00b1 0, 03. Th\u1eddi gian b\u00e1n th\u1ea3i thay \u0111\u1ed5i \u1edf ng\u01b0\u1eddi vi\u00eam gan.<\/p>\n

\u0110\u00e0o th\u1ea3i qua th\u1eadn ch\u1ee7 y\u1ebfu d\u01b0\u1edbi d\u1ea1ng acid salicylic t\u1ef1 do v\u00e0 c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a li\u00ean h\u1ee3p.<\/p>\n

5.3 Gi\u1ea3i th\u00edch: <\/strong><\/p>\n

Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n

5.4 Thay th\u1ebf thu\u1ed1c : <\/strong><\/p>\n

Ch\u01b0a c\u00f3 th\u00f4ng tin. \u0110ang c\u1eadp nh\u1eadt.<\/p>\n

*L\u01b0u \u00fd:<\/em><\/strong><\/p>\n

C\u00e1c th\u00f4ng tin v\u1ec1 thu\u1ed1c tr\u00ean Pharmog.com ch\u1ec9 mang t\u00ednh ch\u1ea5t tham kh\u1ea3o Khi d\u00f9ng thu\u1ed1c c\u1ea7n tuy\u1ec7t \u0111\u1ed1i tu\u00e2n theo theo h\u01b0\u1edbng d\u1eabn c\u1ee7a B\u00e1c s\u0129 <\/em><\/strong><\/p>\n

Ch\u00fang t\u00f4i kh\u00f4ng ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 b\u1ea5t c\u1ee9 h\u1eadu qu\u1ea3 n\u00e0o x\u1ea3y ra do t\u1ef1 \u00fd d\u00f9ng thu\u1ed1c d\u1ef1a theo c\u00e1c th\u00f4ng tin tr\u00ean Pharmog.com<\/em><\/strong><\/p>\n

6. Ph\u1ea7n th\u00f4ng tin k\u00e8m theo c\u1ee7a thu\u1ed1c:<\/strong><\/p>\n

6.1. Danh m\u1ee5c t\u00e1 d\u01b0\u1ee3c:<\/strong><\/p>\n

 <\/p>\n

6.2. T\u01b0\u01a1ng k\u1ef5 :<\/strong><\/p>\n

Kh\u00f4ng \u00e1p d\u1ee5ng<\/p>\n

6.3. B\u1ea3o qu\u1ea3n: <\/strong><\/p>\n

B\u1ea3o qu\u1ea3n n\u01a1i kh\u00f4, nhi\u1ec7t \u0111\u1ed9 kh\u00f4ng qu\u00e1 30oC, tr\u00e1nh \u00e1nh s\u00e1ng.<\/p>\n

6.4. Th\u00f4ng tin kh\u00e1c :<\/strong><\/p>\n

Kh\u00f4ng c\u00f3.<\/p>\n

6.5 T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/strong><\/p>\n

D\u01b0\u1ee3c Th\u01b0 Qu\u1ed1c Gia Vi\u1ec7t Nam<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

1. T\u00ean ho\u1ea1t ch\u1ea5t v\u00e0 bi\u1ec7t d\u01b0\u1ee3c: Ho\u1ea1t ch\u1ea5t : Acetylsalicylic acid (Aspirin) Ph\u00e2n lo\u1ea1i: Thu\u00f4\u0301c kha\u0301ng vi\u00eam Non-steroid (NSAIDS), thu\u1ed1c \u1ee9c ch\u1ebf k\u1ebft t\u1eadp ti\u1ec3u c\u1ea7u. Nh\u00f3m ph\u00e1p l\u00fd: Thu\u1ed1c k\u00ea \u0111\u01a1n ETC \u2013 (Ethical drugs, prescription drugs, Prescription only medicine) M\u00e3 ATC (Anatomical Therapeutic Chemical): B01AC06. Bi\u1ec7t d\u01b0\u1ee3c g\u1ed1c: Bi\u1ec7t d\u01b0\u1ee3c: ASPIRIN 81 […]<\/p>\n","protected":false},"author":1,"featured_media":11968,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[419],"tags":[424],"class_list":["post-11967","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biet-duoc","tag-aspirine"],"_links":{"self":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/11967","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/comments?post=11967"}],"version-history":[{"count":1,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/11967\/revisions"}],"predecessor-version":[{"id":11970,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/posts\/11967\/revisions\/11970"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media\/11968"}],"wp:attachment":[{"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/media?parent=11967"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/categories?post=11967"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pharmog.com\/wp\/wp-json\/wp\/v2\/tags?post=11967"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}